A ketorolac patch composition, ketorolac patch and preparation method and application thereof

By using a combination of solvent-based matrix materials and transdermal enhancers in ketorolac patches, the problem of insufficient transdermal diffusion performance of ketorolac patches has been solved, achieving more efficient drug transdermal diffusion and long-lasting analgesic and anti-inflammatory effects.

CN120267640BActive Publication Date: 2026-04-10WUHAN INST OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
WUHAN INST OF TECH
Filing Date
2025-04-14
Publication Date
2026-04-10

AI Technical Summary

Technical Problem

Existing ketorolac patch compositions have poor transdermal diffusion properties, making it difficult to effectively penetrate the skin barrier and enter the bloodstream, resulting in poor analgesic and anti-inflammatory effects.

Method used

The formulation employs a combination of solvent-based matrix materials and transdermal diffusion enhancers, including acrylic acid and its derivatives, lactic acid, oleic acid, phosphoric acid, etc., combined with crystallization inhibitors such as butyl methacrylate-methyl methacrylate copolymer, to improve the transdermal diffusion performance of drugs.

Benefits of technology

It significantly improves the transdermal diffusion properties of ketorolac patches, making it easier for the drug to cross the skin barrier and enter the bloodstream, extending the effective duration of action to 24-168 hours, and effectively treating moderate to severe pain such as cancer pain and postoperative pain.

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Abstract

The present application provides a ketorolac patch composition, a ketorolac patch and a preparation method and application thereof. The ketorolac patch composition of the present application comprises an active ingredient, a matrix material and a transdermal enhancer, the transdermal enhancer comprises at least two of lactic acid, oleic acid, phosphoric acid, tartaric acid, citric acid, fumaric acid, malic acid, isopropyl myristate, propylene glycol monolaurate, glycerol monooleate, glycerol triacetate, diisopropyl adipate, triethyl citrate, polyglycerol oleate, sorbitan oleate (Span 80); preferably, the transdermal enhancer comprises at least two of isopropyl myristate, triethyl citrate, polyglycerol oleate, glycerol triacetate, oleic acid, sorbitan oleate (Span 80), lactic acid and citric acid; the transdermal enhancer of the present application comprises a complex of at least two of the above-mentioned substances, which can greatly improve the transdermal diffusion performance of the ketorolac patch composition.
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Citation Information

Patent Citations

  • Ramipril-containing external-application slow-release transdermal patch and application thereof

    CN105213355A

  • Ketorolac patch composition, ketorolac patch as well as preparation method and application of ketorolac patch

    CN118873516A

  • Formulation for enhanced transdermal absorption of drug

    US20190091168A1