Traditional Chinese medicine composition and medicine for beautifying and removing freckles and preparation method of traditional Chinese medicine composition

Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for beautifying and removing freckles, a medicine and a preparation method thereof. The invention provides a traditional Chinese medicine composition for beautifying and removing freckles. The traditional Chinese medicine composition is prepared from 8-10 parts of black nightshade herb, 5-8 parts of persimmon leaves, 3-5 parts of radix angelicae, 3-5 parts of common sage herb, 1-2 parts of egg white, 1-2 parts of honey and 1-2 parts of pearl. In the invention, the nightshade is used as a monarch drug, the persimmon leaf and the angelica dahurica are used as ministerial drugs, the common sage herb, the pearl and the egg white are used as adjuvant drugs, and the honey is used as a conductant drug. Results of the specific embodiment of the invention show that the traditional Chinese medicine composition or medicine provided by the invention is high in safety and has a remarkable freckle removing effect, and the highest effective rate of the traditional Chinese medicine composition or medicine can reach 100%.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and particularly to a traditional Chinese medicine composition, a drug and a preparation method thereof for beauty and freckle removal. Background Art

[0002] With the improvement of living standards, people not only pay more and more attention to physical health, but also pay more and more attention to their own appearance. In real life, exposure to wind, sun, various radiations, bad diets, life stress and abuse of antibiotics are likely to cause skin aging, resulting in dull skin and various skin spots. For example, melasma is a pigmentary dermatosis commonly found on the facial skin, especially in middle-aged and young women. It mainly presents as light brown to dark brown patches on the facial skin, with different shapes and sizes, usually symmetrically distributed, appearing on the cheekbones, forehead and perioral area like a spreading butterfly. These patches are smooth on the surface, without scales or inflammatory reactions, and are not accompanied by pain or itching. The formation of melasma is related to multiple factors, including ultraviolet radiation, genetics, endocrine changes (such as hormonal level changes during pregnancy), oral contraceptives, chronic diseases, and improper use of cosmetics. Although melasma does not affect health, it often brings cosmetic troubles and psychological pressure to patients.

[0003] At present, there are a wide variety of freckle-removing and beauty products on the market, specifically including facial masks, freckle-removing creams, skin care lotions, etc. However, most of these products are made of chemical products as raw materials. Although they have certain curative effects, they are very harmful to human skin. In addition, there are also some freckle-removing products made of traditional Chinese medicine ingredients on the existing market. They often achieve the effect of freckle removal and beauty by the superposition of a large number of traditional Chinese medicine components with freckle-removing and whitening effects. Due to the increase in traditional Chinese medicine components, although they can exert the efficacy of each traditional Chinese medicine component, it is also easy to cause reactions between the active ingredients of each traditional Chinese medicine component and the unreasonable proportion of each component, resulting in the failure of each traditional Chinese medicine component to play its maximum role, thereby affecting its overall freckle-removing effect and unable to better meet the market demand. Summary of the Invention

[0004] The purpose of the present invention is to provide a traditional Chinese medicine composition, a drug and a preparation method thereof for beauty and freckle removal, so as to solve the problems existing in the above-mentioned prior art.

[0005] To achieve the above purpose, the present invention provides the following solutions:

[0006] The present invention provides a traditional Chinese medicine composition for beauty and freckle removal, comprising the following components in parts by mass:

[0007] 8 - 10 parts of Solanum nigrum, 5 - 8 parts of persimmon leaves, 3 - 5 parts of Angelica dahurica, 3 - 5 parts of Prunella vulgaris, 1 - 2 parts of egg white, 1 - 2 parts of honey and 1 - 2 parts of pearls.

[0008] Preferably, the traditional Chinese medicine composition comprises the following components in parts by mass:

[0009] 9 parts of Solanum nigrum, 7 parts of persimmon leaves, 4 parts of Angelica dahurica, 4 parts of Prunella vulgaris, 1 part of egg white, 1 part of honey and 2 parts of pearls.

[0010] The present invention provides the application of the above-mentioned traditional Chinese medicine composition in the preparation of a drug for beauty and freckle removal.

[0011] The present invention provides a drug for beauty and freckle removal, and the preparation raw materials of the drug include the above-mentioned traditional Chinese medicine composition.

[0012] Preferably, the drug further comprises pharmaceutically acceptable excipients.

[0013] Preferably, the excipients include glycerol, sodium hydroxide, potassium hydroxide, purified water (deionized water), stearyl alcohol, liquid paraffin, stearic acid, glycerol monostearate and distearate, lanolin, preservatives and lily essence.

[0014] Preferably, the dosage form of the drug is lotion, liniment, ointment, cataplasm or patch.

[0015] The present invention provides a preparation method of the above-mentioned drug, comprising the following steps:

[0016] Crush the Solanum nigrum, the persimmon leaves, the Angelica dahurica and the Prunella vulgaris to obtain a traditional Chinese medicine mixture;

[0017] Perform water extraction, filtration and concentration on the traditional Chinese medicine mixture in sequence to obtain a traditional Chinese medicine extract;

[0018] Crush the pearls to obtain pearl powder;

[0019] Mix the traditional Chinese medicine extract, the egg white, the honey and the pearl powder evenly to obtain the drug.

[0020] Preferably, the number of times of water extraction is 2 times, the time of each water extraction is 30 min, the material-liquid ratio of the first water extraction is 1 g:10 mL, and the material-liquid ratio of the second water extraction is 1 g:12 mL;

[0021] The concentration includes the step of concentrating the filtrate obtained by filtration to a relative density of 1.10-1.15.

[0022] The present invention provides a preparation method of the above-mentioned drug, comprising the following steps:

[0023] Crush the Solanum nigrum, the persimmon leaves, the Acanthopanax senticosus, the Angelica dahurica and the Prunella vulgaris to obtain a traditional Chinese medicine mixture;

[0024] Perform water extraction, filtration and concentration on the traditional Chinese medicine mixture in sequence to obtain a traditional Chinese medicine extract;

[0025] Crush the pearl to obtain pearl powder;

[0026] Mix the clear paste of traditional Chinese medicine, the egg white, the honey and the pearl powder evenly to obtain an active ingredient mixture;

[0027] Mix the adjuvant and the active ingredient mixture evenly to obtain the drug.

[0028] Further preferably, the number of times of water extraction is 2 times, the time of each water extraction is 30 min, the material-liquid ratio of the first water extraction is 1 g: 10 mL, and the material-liquid ratio of the second water extraction is 1 g: 12 mL;

[0029] The concentration includes the step of concentrating the filtrate obtained by filtration to a relative density of 1.10 - 1.15.

[0030] The present invention discloses the following technical effects:

[0031] The present invention provides a traditional Chinese medicine composition and a drug with the efficacy of nourishing the face and removing freckles. In the present invention, Solanum nigrum is the monarch drug, and Solanum nigrum has the effects of clearing heat and detoxifying, and dissipating swelling and nodules. When used externally, it directly acts on the skin surface, with stronger pertinence. Persimmon leaf and Angelica dahurica are the ministerial drugs. Persimmon leaf has the effects of clearing heat and moistening the lungs, and assisting in enhancing the freckle-removing effect. When used externally, it helps to improve the skin condition. Angelica dahurica has the effects of expelling wind and relieving the exterior, and promoting qi and relieving pain, and at the same time has a conditioning effect on the skin, especially in terms of whitening and anti-inflammation. Prunella vulgaris, pearl and egg white are the adjuvant drugs. Prunella vulgaris has a cold property, which can be used to balance the overall warm property of the prescription, and at the same time has the effects of clearing heat, anti-inflammatory and detoxifying. Pearl has unique effects in beauty, especially in whitening and lightening freckles. Egg white can protect the skin, reduce the irritation of the drug, and reconcile the properties of other medicinal materials. Honey is used as the guiding drug, which plays the role of reconciling various medicinal materials, and at the same time has the effect of moistening the skin and promoting the absorption of the drug. The results of the specific embodiments of the present invention show that: the traditional Chinese medicine composition or drug provided by the present invention has high safety, has a significant freckle-removing effect, and its effective rate can reach 100% at most. Specific Embodiments

[0032] Now, various exemplary embodiments of the present invention will be described in detail. This detailed description should not be considered as a limitation of the present invention, but should be understood as a more detailed description of certain aspects, characteristics and implementation schemes of the present invention.

[0033] It should be understood that the terms used in this invention are only for describing particular embodiments and are not intended to limit the invention. Additionally, for the numerical ranges in this invention, it should be understood that each intermediate value between the upper and lower limits of the range is also specifically disclosed. Any intermediate value within any stated value or stated range, as well as each smaller range between any other stated value or intermediate value within the stated range, is also included in this invention. The upper and lower limits of these smaller ranges may be independently included or excluded from the range.

[0034] Unless otherwise specified, all technical and scientific terms used herein have the same meaning as commonly understood by a person of ordinary skill in the art to which this invention pertains. Although this invention only describes preferred methods and materials, any methods and materials similar or equivalent to those described herein can also be used in the implementation or testing of this invention. All documents mentioned in this specification are incorporated by reference to disclose and describe the methods and / or materials related to the documents. In case of conflict with any incorporated document, the content of this specification shall prevail.

[0035] Without departing from the scope or spirit of this invention, various improvements and changes can be made to the specific embodiments of the specification of this invention, which are obvious to those skilled in the art. Other embodiments obtained from the specification of this invention are obvious to those skilled in the art. The specification and examples of this invention are merely exemplary.

[0036] Regarding the use of "comprising", "including", "having", "containing", etc. in this article, they are all open-ended terms, meaning including but not limited to.

[0037] Solanum nigrum: Commonly known as black daylily, nightshade vegetable, etc., it is a plant of the genus Solanum in the Solanaceae family. Solanum nigrum is an annual erect herb, with the whole plant being 30 - 120 cm tall; the stem is erect and much branched; the ovate or heart-shaped leaves are alternate and nearly entire; small white flowers bloom in summer, with 4 - 10 flowers forming an umbel; the berries are spherical and turn black-purple when mature. The whole plant is used as medicine, which can disperse stasis and reduce swelling, clear heat and detoxify, have anti-inflammatory, antihypertensive, sedative and antipyretic effects, and is commonly used for treating carbuncles, traumatic injuries, chronic cough with phlegm, cancer and other diseases.

[0038] Persimmon leaf: Bitter in taste, cold in nature, non-toxic, and specifically enters the lung meridian, having the effects of astringing diarrhea and moisturizing and relieving itching. The main active ingredients of persimmon leaf are flavonoids. In addition, persimmon leaf also includes phenols, organic acids, chlorophyll, carotenoids, and a large amount of vitamin C, amino acids and various trace elements, etc., and has a wide range of pharmacological effects, such as antioxidant, enhancing the vitality of epidermal cells, anti-allergic, antibacterial, anti-inflammatory, enhancing immunity, etc.

[0039] Angelica dahurica: Commonly known as fragrant angelica dahurica, Chinese wild parsnip, etc., it is a plant of the genus Angelica in the Umbelliferae family. Angelica dahurica has the effects of relieving exterior syndrome and dispelling cold, expelling wind and relieving pain, dredging nasal orifices, drying dampness and arresting leukorrhea, detumescence and discharging pus, expelling wind and relieving itching.

[0040] Prunella vulgaris L.: Also known as Salvia plebeia R. Br., with common names such as "Majipo herb", "Zhupo herb", etc., it is an annual or biennial herb belonging to the genus Salvia of the Lamiaceae family. Prunella vulgaris L. is cold in nature, bitter and pungent in taste; it has the effects of clearing heat, cooling blood, promoting diuresis, stopping bleeding, anti-inflammatory, detoxifying, and killing insects. It is applicable to diseases such as carbuncles, hemorrhoids, hemoptysis, metrorrhagia, hematuria, ascites, and sore throat. Clinical verification shows that Prunella vulgaris L. has good effects in treating diseases such as tonsillitis, abdominal distension, nephritis edema, hematochezia, hemorrhoids, mastitis, and vaginitis.

[0041] Egg white: It refers to the translucent liquid inside an egg, so it is also called egg white. Applying egg white on the face has the effects and functions of moisturizing the skin, improving skin quality, shrinking pores, whitening the skin, and reducing inflammation.

[0042] Honey: Honey has the effects of moisturizing and hydrating, improving skin quality, antibacterial and anti-inflammatory, beautifying and nourishing the skin, and reducing melanin deposition.

[0043] Pearl: It has the effects of whitening and moisturizing, anti-inflammatory and acne treatment. Pearl powder contains five components that can change skin quality, namely collagen fibers composed of glycine, methionine, taurine, photobased o-phosphoamino acid, and alkaline phosphate. Collagen fibers can continuously moisturize from the inside out. Methionine can increase the luster and elasticity of the skin. Taurine can improve the skin environment. Photobased o-phosphoamino acid can improve the skin environment. Alkaline phosphate can enhance the vitality of the human epidermis and delay aging. Adding pearls to the freckle removal composition can effectively improve the skin environment and promote the freckle removal effect.

[0044] Unless otherwise specified, the Chinese medicinal materials used in the present invention are all obtained by routine purchase by those skilled in the art, and the methods used in the present invention are all well-known ways to those skilled in the art.

[0045] Example 1

[0046] A traditional Chinese medicine composition for beauty and freckle removal, which is composed of the following components in parts by mass:

[0047] 9 parts of Solanum nigrum L., 7 parts of persimmon leaves, 4 parts of Angelica dahurica (Fisch. ex Hoffm.) Benth. et Hook. f. ex Franch. et Sav., 4 parts of Prunella vulgaris L., 1 part of egg white, 1 part of honey, and 2 parts of pearls.

[0048] A drug for beauty and freckle removal, the preparation raw materials are the above traditional Chinese medicine composition and auxiliary materials, and the auxiliary materials are glycerol, sodium hydroxide, potassium hydroxide, purified water (deionized water), cetyl alcohol, liquid paraffin, stearic acid, glyceryl monostearate, lanolin, preservative, and lily essence.

[0049] The preparation method of the drug is as follows:

[0050] Crush Solanum nigrum L., persimmon leaves, Angelica dahurica (Fisch. ex Hoffm.) Benth. et Hook. f. ex Franch. et Sav., and Prunella vulgaris L. to obtain a traditional Chinese medicine mixture with a particle size of 40 μm;

[0051] Mix the traditional Chinese medicine mixture and water in a ratio of 1 g: 10 mL of solid-liquid ratio for water extraction. The temperature of water extraction is 75 °C and the time is 30 min to obtain the first water extract and the first water extract residue.

[0052] Mix the first water extract residue and water in a ratio of 1 g: 12 mL of solid-liquid ratio for water extraction. The temperature of water extraction is 75 °C and the time is 30 min to obtain the second water extract and the second water extract residue.

[0053] Mix the first water extract and the second water extract, and conduct 0.22 μm filtration and concentration until the relative density is 1.10 - 1.15 to obtain the clear paste.

[0054] Crush the pearls to obtain pearl powder with a particle size of 40 μm.

[0055] Mix the clear paste, egg white, honey and pearl powder to obtain the active ingredient mixture.

[0056] Mix the active ingredient mixture, glycerol, sodium hydroxide, potassium hydroxide, purified water (deionized water), stearyl alcohol, liquid paraffin, stearic acid, glyceryl monostearate and distearate, lanolin, preservative IS45 and lily essence in a mass ratio of 1.5: 1: 0.2: 0.3: 50: 1: 0.8: 1: 0.2: 0.1: 0.05: 0.01 to obtain the drug.

[0057] Example 2

[0058] A traditional Chinese medicine composition for beauty and freckle removal is composed of the following components in parts by mass:

[0059] 10 parts of Solanum nigrum, 5 parts of persimmon leaf, 5 parts of Angelica dahurica, 3 parts of Prunella vulgaris, 2 parts of egg white, 1 part of honey and 2 parts of pearls.

[0060] A drug for beauty and freckle removal, the preparation raw materials are the above traditional Chinese medicine composition and adjuvants. The adjuvants are glycerol, sodium hydroxide, potassium hydroxide, purified water (deionized water), stearyl alcohol, liquid paraffin, stearic acid, glyceryl monostearate and distearate, lanolin, preservative and lily essence. The preparation method of this drug is the same as that of Example 1.

[0061] Example 3

[0062] A traditional Chinese medicine composition for beauty and freckle removal is composed of the following components in parts by mass:

[0063] 8 parts of Solanum nigrum, 8 parts of persimmon leaf, 3 parts of Angelica dahurica, 2 parts of Prunella vulgaris, 1 part of egg white, 2 parts of honey and 1 part of pearls.

[0064] A drug for beauty and freckle removal, the raw materials for preparation are the above-mentioned Chinese medicine composition and auxiliary materials, the auxiliary materials are glycerol, sodium hydroxide, potassium hydroxide, purified water (deionized water), octadecyl alcohol, liquid paraffin, stearic acid, mono- and distearic acid glyceryl, lanolin, preservatives and lily essence. The preparation method of the drug is the same as that of Example 1.

[0065] Comparative Example 1

[0066] A Chinese medicine composition for beauty and freckle removal, comprising the following components in parts by weight:

[0067] 7 parts of persimmon leaves, 4 parts of angelica dahurica, 4 parts of snow primrose, 1 part of egg white, 1 part of honey and 2 parts of pearls.

[0068] A drug for beauty and freckle removal, the raw materials for preparation are the above-mentioned Chinese medicine composition and auxiliary materials, the auxiliary materials are glycerol, sodium hydroxide, potassium hydroxide, purified water (deionized water), octadecyl alcohol, liquid paraffin, stearic acid, mono- and distearic acid glyceryl, lanolin, preservatives and lily essence. The preparation method of the drug is the same as that of Example 1.

[0069] Comparative Example 2

[0070] A Chinese medicine composition for beauty and freckle removal, comprising the following components in parts by weight:

[0071] 7 parts persimmon leaves and 2 parts pearls.

[0072] A drug for beauty and freckle removal, the raw materials for preparation are the above-mentioned Chinese medicine composition and auxiliary materials, the auxiliary materials are glycerol, sodium hydroxide, potassium hydroxide, purified water (deionized water), octadecyl alcohol, liquid paraffin, stearic acid, mono- and distearic acid glyceryl, lanolin, preservatives and lily essence. The preparation method of the drug is the same as that of Example 1.

[0073] Comparative Example 3

[0074] A Chinese medicine composition for beauty and freckle removal, comprising the following components in parts by weight:

[0075] 9 parts of Ligusticum chuanxiong, 7 parts of Persimmon Leaves, 4 parts of Angelica dahurica, 4 parts of Snow Primrose, 1 part of egg white, 1 part of honey and 2 parts of pearls.

[0076] A drug for beauty and freckle removal, the raw materials for preparation are the above-mentioned Chinese medicine composition and auxiliary materials, the auxiliary materials are glycerol, sodium hydroxide, potassium hydroxide, purified water (deionized water), octadecyl alcohol, liquid paraffin, stearic acid, mono- and distearic acid glyceryl, lanolin, preservatives and lily essence. The preparation method of the drug is the same as that of Example 1.

[0077] Experimental Example 1: Toxicity test in mice

[0078] Experimental animals: 60 Kunming mice, weighing about 50g, half male and half female, selected 2×2cm on the back of each mouse2 The surface area was depilated to remove mouse hair and used as the test site. The drugs prepared in Examples 1-3 and Comparative Examples 1-3 were respectively applied to the test sites of the mice, with a dosage of 0.1 g for each test site, twice a day, 12 h apart each time, and the application period was 30 days. After 30 days, the test sites on the backs of the mice were observed for any abnormal phenomena. The results showed that there were no abnormal phenomena in the mice, and the surfaces of the test sites were smooth, fair and white. It was indicated that the drugs in Examples 1-3 and Comparative Examples 1-3 were safe for clinical application.

[0079] Experimental Example 2 Mouse Model Experiment

[0080] According to the "Preparation Specification for Melasma Animal Model (Draft)" (Journal of Traditional Chinese Medicine New Drugs and Clinical Pharmacology, Vol. 28, No. 5, September 2017), a mouse melasma model was prepared by systemic attack with progesterone. Female mice aged 6-8 weeks and weighing 18-22 g were selected, and progesterone injection (20 mg·kg -1 ) was intramuscularly injected into the hind limbs once a day for 35 consecutive days. Progesterone was injected into the two hind limbs alternately to prepare a mouse melasma model. The prepared melasma model mice were randomly divided into two groups, namely the test group and the control group; at the same time, spotless mice were selected to apply freckle cream as a control; a surface area of 2×2 cm 2 on the back of each mouse was depilated to remove mouse hair and used as the test site.

[0081] The test method was as follows:

[0082] Test group: 0.2 g of the drug (Examples 1-3 and Comparative Examples 1-3) was respectively applied to the test sites of the mice, twice a day, 12 h apart each time, and the application period was 30 days;

[0083] Control group: 0.2 g of purified water was respectively applied to the test sites of the mice, twice a day, 12 h apart each time, and the application period was 30 days.

[0084] There were 10 mice in each treatment. After 30 days, the mice were sacrificed after administration, and the melasma area of the test sites on the backs of the mice was observed. The melasma area could be measured by an image analyzer, and the test results are shown in Table 1.

[0085] Table 1 Results of Mouse Model Experiment (n = 10)

[0086] Treatment <![CDATA[Melasma area (cm 2 )]]> Example 1 0.3 Example 2 0.6 Example 3 0.5 Comparative Example 1 1.3 Comparative Example 2 1.5 Comparative Example 3 1.1 Control 0 Control group 4

[0087] As can be seen from Table 1, the traditional Chinese medicine composition and drug provided by the present invention can significantly improve melasma and reduce the area of melasma. Thus, it can be seen that the traditional Chinese medicine composition and drug provided by the present invention have a good effect on removing melasma.

[0088] Experimental Example 3 Clinical Experiment

[0089] 1. Clinical data

[0090] A total of 60 subjects were all female patients, and the average age of female patients was 38 years old.

[0091] 1.1 Inclusion criteria

[0092] Patients with chloasma on the face who voluntarily participated.

[0093] 1.2 Exclusion criteria

[0094] Minors and patients with other skin lesions were excluded; patients allergic to the Chinese medicinal materials or excipients used were excluded; patients who could not abide by the rules were excluded.

[0095] 2. Treatment method

[0096] The drugs prepared in Examples 1-3 and Comparative Examples 1-3 of the present invention were used for treatment, and each group of test subjects corresponded to one drug. The usage method of each composition was that after cleansing the face, the drug was applied to the skin surface, gently massaged with the fingertips until absorbed, and then rinsed. The dosage was 5 g / person. Once a day, 30 days was a course of treatment, and a total of 1 course of treatment was used. After 1 course of treatment, follow-up treatment was carried out according to the patient's condition.

[0097] 3. Efficacy judgment criteria

[0098] Marked effect: The chloasma on the face disappeared;

[0099] Effective: The chloasma on the face faded;

[0100] Ineffective: The chloasma on the face did not change or worsened.

[0101] 4. Efficacy evaluation results

[0102] The efficacy evaluation results are shown in Table 2.

[0103] Table 2 Efficacy evaluation

[0104] Treatment Marked effect Effective Ineffective Example 1 2 8 0 Example 2 1 8 1 Example 3 0 9 1 Comparative Example 1 0 6 4 Comparative Example 2 0 4 6 Comparative Example 3 0 5 5

[0105] It can be seen from Table 2 that the drugs prepared in the examples of the present invention all have excellent freckle-removing effects, and the highest effective rate can reach 100%. Among them, the drug prepared from the traditional Chinese medicine composition of Example 1 has the best freckle-removing effect.

[0106] The above-described embodiments are only descriptions of the preferred embodiments of the present invention, and do not limit the scope of the present invention. Without departing from the design spirit of the present invention, various deformations and improvements made by those of ordinary skill in the art to the technical solutions of the present invention shall fall within the protection scope determined by the claims of the present invention.

Claims

1. A traditional Chinese medicine composition for beauty and freckle removal, characterized in that, Comprising the following components in parts by mass: 8 - 10 parts of Solanum nigrum, 5 - 8 parts of persimmon leaves, 3 - 5 parts of Angelica dahurica, 3 - 5 parts of Prunella vulgaris, 1 - 2 parts of egg white, 1 - 2 parts of honey, and 1 - 2 parts of pearls.

2. The traditional Chinese medicine composition according to claim 1, wherein The traditional Chinese medicine composition comprises the following components in parts by mass: 9 parts of Solanum nigrum, 7 parts of persimmon leaves, 4 parts of Angelica dahurica, 4 parts of Prunella vulgaris, 1 part of egg white, 1 part of honey, and 2 parts of pearls.

3. Use of the traditional Chinese medicine composition according to claim 1 or 2 in the preparation of a drug for beauty and freckle removal.

4. A drug for beauty treatment and freckle removal, characterized in that, The preparation raw materials of the drug include the traditional Chinese medicine composition according to claim 1 or 2.

5. The medicament according to claim 4, characterized in that, The drug further comprises pharmaceutically acceptable excipients.

6. The drug according to claim 5, characterized in that, The excipients include glycerol, sodium hydroxide, potassium hydroxide, purified water, cetostearyl alcohol, liquid paraffin, stearic acid, glyceryl monostearate and distearate, lanolin, preservatives, and lily essence.

7. The drug according to claim 5, characterized in that, The dosage form of the drug is lotion, liniment, ointment, cataplasm, or patch.

8. The preparation method of the drug according to claim 4, characterized in that, Comprising the following steps: Crush the Solanum nigrum, the persimmon leaves, the Angelica dahurica, and the Prunella vulgaris to obtain a traditional Chinese medicine mixture; Perform water extraction, filtration, and concentration on the traditional Chinese medicine mixture in sequence to obtain a traditional Chinese medicine extract; Crush the pearls to obtain pearl powder; Mix the traditional Chinese medicine extract, the egg white, the honey, and the pearl powder evenly to obtain the drug.

9. The preparation method according to claim 4, characterized in that The number of times of water extraction is 2 times, the time of each water extraction is 30 min, the material - liquid ratio of the first water extraction is 1 g:10 mL, and the material - liquid ratio of the second water extraction is 1 g:12 mL; The concentration includes the step of concentrating the filtrate obtained by filtration to a relative density of 1.10 - 1.

15.

10. A method for preparing the drug according to claim 5, characterized in that, Comprising the following steps: Crush the Solanum nigrum, the persimmon leaves, the Angelica dahurica, and the Prunella vulgaris to obtain a traditional Chinese medicine mixture; Perform water extraction, filtration, and concentration on the traditional Chinese medicine mixture in sequence to obtain a traditional Chinese medicine extract; Crush the pearls to obtain pearl powder; Mix the traditional Chinese medicine extract, the egg white, the honey, and the pearl powder evenly to obtain an active ingredient mixture; Mix the excipients and the active ingredient mixture evenly to obtain the drug.