Insecticide containing m-diamide compound and application thereof

Abstract

The invention belongs to the technical field of agricultural insecticides, and relates to an insecticidal preparation containing m-diamide compounds (as shown in a general formula I) and application of the insecticidal preparation. The insecticide is an m-diamide compound as shown in a general formula I, at least one carrier and at least one surfactant, wherein the weight percentage of the m-diamide compound as shown in the general formula I is 0.1-99%; the structure of the m-diamide compound shown in the general formula I is shown in the specification. The pesticide composition disclosed by the invention has the characteristics of good wetting, spreading and permeation of pesticide liquid on a target, less rebound of the pesticide liquid on the target, large liquid holdup, large deposition amount, small evaporation, large absorption rate, high biological activity, safety to crops and the like, and is an ideal pesticide variety for preventing and treating pests of lepidoptera, coleoptera, thysanoptera and the like at present. # imgabs0 #

Description

Technical Field

[0001] The present invention belongs to the technical field of agricultural insecticides, and relates to an insecticidal preparation containing a meta-diamide compound (as shown in general formula I) and its application. Background Art

[0002] As is well known, insecticides play an extremely important role in controlling pests in agriculture, forestry or urban sanitation. The meta-diamide insecticide (as shown in general formula I) disclosed in Chinese Patent (Patent No.: CN 112457288 B) is an innovative insecticide independently developed by Shenyang Sinochem Agrochemicals R & D Co., Ltd. It has a novel chemical structure and a unique action mechanism, and has effects such as stomach toxicity, contact toxicity, and systemic absorption. It has excellent activity against pests such as Lepidoptera, Coleoptera, Hemiptera, Diptera, Hymenoptera, and Thysanoptera, and is a highly efficient insecticide with broad market application prospects.

[0003] The quality of pesticide formulations and preparations is a key factor determining the efficacy and value of pesticide products. Pesticides themselves are a special type of chemicals with biological activity. To endow the active ingredient with the best efficacy, it is necessary to select an adjuvant system that matches the active ingredient. Although adjuvants themselves have no biological activity, they can assist the technical material to disperse quickly, evenly and stably in the spray carrier, ensure the distribution and adhesion of the pesticide solution on the surface of organisms (plant leaves and insect bodies), promote the absorption of the agent by organisms, and even increase the conduction of the agent in organisms, so as to increase the retention amount of pesticides on the plant surface, extend the retention time and improve the penetration ability of the plant epidermis, thereby enhancing the biological activity of pesticides, reducing the dosage, and reducing the harm of pesticides to humans and environmental pollution. When preparing formulations, an appropriate adjuvant system needs to be selected according to different technical materials and different formulations. Through the interaction between the adjuvant system and the technical material, the efficacy of the active ingredient can be exerted to a greater extent. Therefore, it is very important to select an adjuvant system that matches the active ingredient and the added dosage. At the same time, corresponding preparations are formulated for application according to needs, such as nano-suspensions, nano-emulsions, nano-microemulsions, nano-granules, electrostatic sprays, thermal foggers, aerosols, emulsifiable powders (granules), effervescent tablets (granules), tablets, smoke agents, bait agents, coil incense, electric heating liquid mosquito repellents, microcapsule suspensions, microcapsule granules, etc. Different preparation products have different advantages to meet the different crop and farmer medication habits. Although the m -diamide compounds (as shown in general formula I) can be used by first dissolving them in an organic solvent (such as acetone, and the content of acetone in the total solution does not exceed 10%) and then preparing a solution with the required concentration with 0.1% Tween 80 aqueous solution as the spraying liquid, there are great defects. On the one hand, it is prepared and used immediately, which is rather troublesome to apply. The consumption of organic solvents is large, which has a great impact on the environment and is costly. On the other hand, the prepared solution needs to be used immediately, and the active ingredient is very likely to precipitate after long-term storage and cannot be used next time. However, there are no such problems when formulating corresponding preparations for application according to needs. The purpose of the present invention is to improve the biological activity of pesticides, reduce the dosage, lower the cost, maximize the hitting of the target with the least amount of pesticides used, and improve the compatibility with the environment. Summary of the Invention

[0004] To achieve the purpose of the present invention, the inventor, according to its action target and application method, developed an insecticidal preparation of m -diamide compounds (as shown in general formula I) by finding adjuvant varieties that match the active ingredient, so as to improve the wetting, spreading, dispersing, retention and penetration properties of the active ingredient on pests or the medium in which they grow, thereby increasing the retention amount of the pesticide active ingredient on the plant surface, extending the retention time and improving the penetration ability of the plant epidermis, and further enhancing the biological activity of pesticides and reducing the dosage.

[0005] To achieve the purpose of the present invention, the technical solution of the present invention is as follows:

[0006] An insecticide containing a meta-diamide compound, the insecticide being a meta-diamide compound represented by the general formula I, at least one carrier and at least one surfactant; wherein, the weight percentage content of the meta-diamide compound represented by the general formula I is 0.1-99%;

[0007] The meta-diamide compound represented by the general formula I has the following structure:

[0008]

[0009] In the formula:

[0010] X 1 and X 3 can be the same or different and are selected from halogens;

[0011] X 2 is selected from H or halogen;

[0012] X 4 is selected from halogenated C1-C3 alkyl;

[0013] R is selected from H, C1-C6 alkyl, halogenated C1-C6 alkyl.

[0014] Preferably, in the general formula I:

[0015] X 1 is selected from F;

[0016] X 2 is selected from H or F;

[0017] X 3 is selected from Cl, Br, I;

[0018] X 4 is selected from -CF3, -CHF2;

[0019] R is selected from H, C1-C6 alkyl.

[0020] Further preferably, in the general formula I:

[0021] X 1 and X 2 are selected from F;

[0022] X 3 is selected from Br;

[0023] X 4 is selected from -CHF2;

[0024] R is selected from H, C1-C6 alkyl.

[0025] More preferably, in the general formula I:

[0026] X 1, X 2 selected from F;

[0027] X 3 selected from Br;

[0028] X 4 selected from -CHF2;

[0029] R is selected from H, methyl, ethyl, n-propyl.

[0030] The insecticide is a nano-suspension, nano-emulsion, nano-microemulsion, nano-granule, electrostatic spray, thermal fogging agent, aerosol, emulsifiable powder (granule), effervescent tablet (granule), tablet, smoke agent, bait, coil incense, electric heating liquid mosquito repellent, microcapsule suspension, microcapsule granule.

[0031] In any case, the choice of formulation type depends on the physical, chemical and biological properties of compound A. The content of the active ingredient in the composition is between 0.1% and 99%, preferably 5 - 90%. The optimal range of the active ingredient content varies according to the formulation type of the composition.

[0032] The insecticidal formulation of the present invention can be prepared by conventional processing methods. Usually, the composition contains at least one carrier and at least one surfactant. That is, the active substance is mixed with a liquid solvent and / or a solid carrier, and one or several surfactants are added, such as emulsifiers, dispersants, stabilizers, wetting agents. Adhesives, defoamers, oxidants, fuming agents, flame retardants, cooling agents, fuels, dyes or flavoring agents can also be added. In all cases, it should be ensured that the active ingredient of the composition of the present invention is evenly distributed.

[0033] The nano-suspension mixes the technical material, surfactant, antifreeze, water, etc., and after sand grinding, a stable non-depositing and flowable product can be obtained. It usually contains 5 - 75% active ingredient, 5 - 15% surfactant, 4 - 10% antifreeze, and other additives such as defoamers, preservatives, stabilizers, penetrants and thickeners 0 - 10%, with the balance being water.

[0034] The nano-emulsion forms an oil phase by mixing the technical material, organic solvent, surfactant; mixes water and antifreeze to form a homogeneous and transparent aqueous phase. Using a high-shear emulsifier to shear the oil phase at high speed, and slowly adding the aqueous phase to the oil phase. Usually, the active ingredient is 1 - 60%, the surfactant is 5 - 20%, the antifreeze is 2 - 10%, and the balance is water.

[0035] The nano-microemulsion mixes the technical material, organic solvent, surfactant, water together to form a homogeneous and transparent aqueous phase. Usually, the active ingredient is 1 - 50%, the surfactant is 10 - 40%, the antifreeze is 2 - 10%, and the balance is water.

[0036] The nanoparticle agent is a mixture of the active ingredient and the carrier. Usually, the active ingredient accounts for 1 - 50%, the surfactant accounts for 2 - 15%, and the carrier makes up the balance.

[0037] The emulsifiable powder (granule) agent is a mixture of the active ingredient, organic solvent, and surfactant, forming a homogeneous transparent oil phase, and then evenly spraying it on the pre - pulverized carrier. Usually, the active ingredient accounts for 1 - 30%, the surfactant accounts for 10 - 40%, the organic solvent accounts for 0 - 15%, and the carrier makes up the balance.

[0038] The effervescent tablet (granule) agent is a mixture of the active ingredient, surfactant, and carrier, which is pulverized and then kneaded into granules (or pressed into tablets). Usually, the active ingredient accounts for 0.5 - 30%, the surfactant accounts for 2 - 15%, and the carrier makes up the balance.

[0039] The aerosol is a mixture of the active ingredient, organic solvent, and surfactant, forming a homogeneous transparent oil phase. Usually, the active ingredient accounts for 0.1 - 10%, the surfactant accounts for 2 - 15%, and the carrier makes up the balance.

[0040] The microcapsule suspension is a tiny container with a core - shell structure formed by natural or synthetic polymer materials, encapsulating the active ingredient and organic solvent, and suspending it in the continuous phase (water or other oily solvents). Usually, the active ingredient accounts for 1 - 50%, the surfactant accounts for 5 - 15%, the antifreeze accounts for 4 - 10%, and other additives such as defoamers, preservatives, stabilizers, penetrants, and thickeners account for 0 - 10%, with water making up the balance.

[0041] The electrostatic spray agent is a mixture of the active ingredient, organic solvent, and surfactant, forming a homogeneous transparent oil phase. Usually, the active ingredient accounts for 0.5 - 15%, the surfactant accounts for 5 - 25%, and the organic solvent makes up the balance.

[0042] The thermal fog agent is a mixture of the active ingredient, organic solvent, and surfactant, forming a homogeneous transparent oil phase. Usually, the active ingredient accounts for 0.5 - 15%, the surfactant accounts for 5 - 25%, and the organic solvent makes up the balance.

[0043] The smoke agent is composed of the active ingredient and the heating agent (including: oxidant, fuel, additives). Usually, the active ingredient accounts for 5 - 20%, the oxidant accounts for 20 - 50%, the fuel, additives (including: fuming agent, ignition agent, flame retardant, cooling agent, weighting agent, moisture - proof agent, binder, stabilizer) account for 5 - 20%, and the fuel makes up the balance.

[0044] The tablet is a mixture of the active ingredient, surfactant, and carrier, which is pulverized and then pressed into tablets. Usually, the active ingredient accounts for 0.5 - 30%, the surfactant accounts for 2 - 15%, and the carrier makes up the balance.

[0045] The bait agent is composed of the active ingredient, attractant, feeding stimulant, preservative, and water. Usually, the active ingredient accounts for 0.1 - 1%, the attractant accounts for 1 - 5%, the feeding stimulant accounts for 20 - 70%, the preservative accounts for 0.1 - 0.5%, and the water makes up the balance.

[0046] The coil incense is composed of an active ingredient, a surfactant and wood powder. Usually, the active ingredient is 0.1-0.5%, the surfactant is 1-10%, the additives (pigment, mildew-proof agent) are 0.1-2%, and the balance is wood powder.

[0047] The electric heating liquid incense is a homogeneous and transparent oil phase formed by mixing an active ingredient, an organic solvent and a surfactant. Usually, the active ingredient is 0.1-0.3%; the surfactant is 0-15%; and the balance is the solvent.

[0048] The microcapsule granule (sustained release granule) is prepared by mixing, pulverizing an active ingredient, a surfactant and a carrier, and then coating with an adhesive. Usually, the active ingredient is 0.5-10%, the surfactant is 2-10%, and the balance is the carrier.

[0049] The finished preparation of the composition of the present invention can be prepared using carriers (liquid or solid) and various auxiliaries well-known to those skilled in the art. For example, it includes but is not limited to the following substances.

[0050] The surfactants included in the pesticidal preparation composition of the present invention include fatty alcohol polyoxyethylene ethers, alkylphenol polyoxyethylene ethers, fatty amine polyoxyethylene ethers, fatty acid polyoxyethylene ethers, acid alcohol esters and their polyoxyethylene ethers, fatty acid amides and their polyoxyethylene ethers, alkanolamides and their polyoxyethylene ethers, polyoxyethylene-polyoxypropylene block copolymers, sodium alkylnaphthalenesulfonate fatty alcohol polyoxyethylene ethers, sorbitan fatty acid ester polyoxyethylene ethers, etc. For example: emulsifier SK-50EC, emulsifier SK-51EC, emulsifier 1601, emulsifier 0201B, emulsifier 0203B, emulsifier 500, emulsifier 600, emulsifier 700, emulsifier NP-10, dispersant SK-33L, dispersant SK-33H, emulsifier OX-8686, emulsifier OX-2681, emulsifier 2201, emulsifier OX-690, dispersant DURAMAX TM D-205, dispersant DURAMAX TM D-305, wetting agent DURAMAX TM W600, dispersant DURAMAX TM D800, emulsifier SK-5208T, emulsifier SK-5215T, emulsifier YUS-D625, emulsifier YUS-135B, emulsifier YUS-EC2200, emulsifier SK-5026ECH, emulsifier YUS-110, emulsifier SK-5212T, emulsifier YUS-A41B, emulsifier Emulson AG / 18C, emulsifier Greenmul 5100, dispersant TANEMULSPS29, dispersant DURAMAX TMD865, Emulsifier YUS-2010CX, Emulsifier S-80, Emulsifier T-20, Emulsifier SK-5935, Dispersant YUS-D3020, Dispersant SK-20TX, Dispersant SD811, Wetting Agent SP-3266E, Dispersant SP-2728, Dispersant SP-SC29, Dispersant SP-SC3E, Dispersant SP-28F, Dispersant SP-2750, Dispersant SP-DF2222, Dispersant SP-DF2296, Dispersant SP-3275, Dispersant SP-3219, Dispersant SP-NS5324, Dispersant SP-NS5348, Dispersant SP-NS5360, Dispersant SP-NS5366, Dispersant SP-NS5395, Dispersant SP-3509, Dispersant SP-ZR5210, Dispersant TENSIOFIX SC, TENSIOFIX 96DB10, Wetting Dispersant SF133, Wetting Agent TENSIOFIX BCZ, Dispersant D425, Dispersant YUS-FS1, Dispersant YUS-FS3000, Dispersant YUS-FS3300, Dispersant YUS-FS7PG, Dispersant YUS-TXC, Dispersant Disperse 1700, Dispersant SP-2836, Dispersant SP-27001, Greensperse BE02, Greensperse BE23, TANEMUL DA2883, TANEMUL DA2880, TANEMUL DA260, Dispersant Atlox 4913, Dispersant XN-45S, Emulsifier 507, Dispersant SK-33SC, Dispersant SK-541, Dispersant SK-551, Dispersant SK-94S7, Dispersant SK-551G, Dispersant Emulson TRN14105, Dispersant ULTRASURF 7023A, Dispersant FS981, Emulsifier SK-5218CP, Emulsifier SK-5220T, Dispersant SK-92FS1, Emulsifier YUS-CP120, Triphenylvinylphenol Polyoxyethylene(n 20)Triethanolamine salt of ether phosphoric acid, synergist SK-41G, synergist SK-41CN, synergist SK-41A, dispersant ULTRASURF OD21, dispersant ULTRASURF OD23, emulsifier YUS-OD1200, emulsifier AEO-3, dispersant SP-OF3468, dispersant SP-OF3472, dispersant G-VO / 02N, dispersant Greenmul EF68, dispersant Greenmul EF46, dispersant Atlox 4912, dispersant Atlox 4914, dispersant GR7M, emulsifier OX-635, emulsifier OX-622, emulsifier OX-653, emulsifier OX-667, emulsifier AEO-9, emulsifier T-85, dispersant YUS-5050PB, dispersant YUS-EP70G, dispersant YUS-WG5, SP-4302 (humidity synergist), dispersant VE / 10, dispersant OE / 02, dispersant OE / 03, dispersant OE / 08, dispersant OE / 09, dispersant OE150, dispersant Emulson CO40, dispersant Emulson AG / 1100, ULTRASURF O / 23, sodium salt of alkyl naphthalene sulfonic acid condensate, sodium methyl naphthalene sulfonate formaldehyde condensate, polycarboxylate dispersant GY-D800, polycarboxylate dispersant GY-D04, polycarboxylate dispersant GY-D02, naphthalene sulfonate formaldehyde condensate, sodium salt of naphthol sulfonic acid formaldehyde condensate, sodium methylene naphthalene sulfonate, sodium oleic acid methyl aminoethyl sulfonate, dispersant sodium lignosulfonate, dispersant alkyl naphthalene sulfonate formaldehyde condensate, dispersant alpha-olefin sulfonate, dispersant SP-SC3, Darun dispersant D909S, alkyl naphthalene sulfonate formaldehyde condensate (NNO), dispersant YUS-NV1420, dispersant YUS-WG4, dispersant YUS-WP1, dispersant YUS-CH7000, emulsifier PICO-LOE, dispersant PICO-CS300M, dispersant PICO-SF3, dispersant PICO-SWP1, dispersant PICO-SF1, dispersant GeroponUltrasperse, dispersant GeroponExtra, dispersant Soprophor SC, dispersant Geropon DA1349, dispersant TENSIOFIX LX SPECIAL, dispersant TENSIOFIX DB08, dispersant Tensiofix AMS303, dispersant Tensiofix XA265, dispersant Tensiofix EW70, dispersant Tensiofix96DB10, Dispersant TENSIOFIX B9718, Dispersant SK-24R, Dispersant SK-24, Dispersant SK-25CH, Dispersant SK-34SC, Dispersant YUS-CH1100, Dispersant NS-500LQ, Dispersant Supragil MNS / 90, Dispersant Soprophor FD, Dispersant Soprophor TSP / 461, Dispersant Soprophor 796 / P, Dispersant SD819, Dispersant Morwet D-400, Dispersant Morwet D-360, Dispersant Morwet D-390, Dispersant Geronol ODessa 01, Dispersant SD-610, Dispersant SD816, Dispersant Geronol ODessa 05, Dispersant YUS-D935, Dispersant TANEMUL DA266, Dispersant TANEMUL AG281, Dispersant DS609, Dispersant DS809, Dispersant DS733, Dispersant DS567, Dispersant DS6008, Dispersant DSE1122, Dispersant D380, Dispersant DW105, Dispersant D252, Dispersant Lignin DX-1, Dispersant BIT 20W, Octylphenol Polyoxyethylene Ether Sulfate, Sodium Alcohol Polyoxyethylene Ether Sulfate, Wetting Agent Tensiofix D33, Synergist TWEEN L-1010, Dispersant Morwet D450, Wetting Agent Morwet EFW, Wetting Agent Igepal BC / 10, Wetting Agent GEROPON L-WET / P, Wetting Agent Supragil WP, Wetting Agent Supragil GN, Wetting Agent Rhodasurf 860 / p, Emulsifier YUS-A51G, Wetting Agent YUS-LXC, Wetting Agent YUS-SXC, Penetrant Anhydrous Fast T-80J, Sodium Isopropylnaphthalenesulfonate, Sodium Alcohol Polyoxyethylene Ether Sulfate, Alkylphenol Polyoxyethylene Ether Formaldehyde Condensate Sulfate, Alkyl Sulfosuccinate, Sodium Lauryl Alcohol Polyoxyethylene Ether Sulfonate, Sodium Dodecylbenzenesulfonate, Sodium Dodecyl Sulfate, Calcium Dodecylbenzenesulfonate, Azone, Calcium Lignosulfonate, Alkylamidotaurate, etc.

[0051] The carrier contained in the pesticidal preparation composition of the present invention can be solid or liquid, and any carrier commonly used for formulating pesticidal compositions can be used.

[0052] If water is used as a solvent or diluent, organic solvents can also be used as auxiliary solvents or antifreeze additives. Suitable organic solvents include aromatic hydrocarbons, chlorinated aromatic hydrocarbons, aliphatic hydrocarbons, chlorinated aliphatic hydrocarbons, etc. Particularly suitable are polar solvents such as alcohols and their ethers and esters, ketones, etc., as well as vegetable oils. Mixtures of different liquids are often suitable. For example, methanol, ethanol, isopropanol, butanol, ethylene glycol, ethylene glycol methyl ether, propylene glycol, glycerol, sorbitol, benzyl alcohol, furfuryl alcohol, cyclohexanol, acetone, methyl ethyl ketone, methyl isobutyl ketone, cyclohexanone, N-methyl-pyrrolidone, N,N-dimethyl decanamide, N,N-dimethylacetamide, triethyl phosphate, tributyl phosphate, triphenyl phosphate, methyl oleate, butyl butyrate, eucalyptus oil, isopropyl myristate, dimethylformamide, dimethyl sulfoxide, methyl palmitate, methyl coconutate, methylated soybean oil, methylnaphthalene, acetophenone, triphenyl phosphate sulfate, dibutyl phthalate, Armid DM10, Armid FMPC, Rhodiasolv Green SV-92, Rhodiasolv GreenSV-33, Rhodiasolv Green SV-17, Rhodiasolv Green 25, solvent oil S-150, solvent oil S-200, light mineral oil, paraffin wax and kerosene, etc. Mixtures of different liquids are often suitable.

[0053] Suitable solid carriers include natural or synthetic ones, such as: clay, rock powder, chalk, quartz, clay, montmorillonite, sodium sulfate, silica, diatomaceous earth, pumice, gypsum, talc, bentonite, kaolin, attapulgite, light calcium carbonate, pottery clay, montmorillonite, magnesium aluminum silicate, activated clay, precipitated silica, trimethylamine hydrochloride, ammonium sulfate, benzofuran resin, superphosphate, alumina, calcite, marble, pumice, etc. Suitable particulate carriers include crushed and sized natural rocks such as sepiolite and dolomite and synthetic particles made from organic and inorganic powders.

[0054] Suitable thickeners can be synthetic (such as carboxymethyl alcohol, polyvinyl alcohol, polyvinyl acetate) or natural water-soluble polymers (such as xanthan gum, MHF-80, gelatin, gum arabic, polyvinylpyrrolidone, PVPK30, magnesium aluminum silicate, TENSIOFIX 869, polyvinyl alcohol, polyethylene glycol, phenolic resin, shellac, methyl cellulose, soluble starch, sodium carboxymethyl starch, carboxymethyl cellulose and sodium alginate, etc.), and are added to the preparation in the form of powder, granules or latex.

[0055] Suitable defoamers are: antifoam agent, defoamer SAG1522, defoamer SAG1572, AG-2501, AG2905, AGT735, AGT530, WJX-1, AGRIGENLF030, defoamer RH-9520, SXP-830, silicone-based, C8～10 Fatty alcohols, phosphates, C 10～20 Saturated fatty acids (such as capric acid) and amides, etc.

[0056] The binder is: elm bark powder, polyvinyl alcohol, polyethylene glycol, soluble starch, sodium carboxymethyl starch, carboxymethyl cellulose, sodium alginate, etc.

[0057] The effervescent disintegrant is: the acidic component is organic acid, inorganic acid, such as: tartaric acid, citric acid, salicylic acid, phosphoric acid, etc.; the basic component is basic carbonate, carbonate, such as: sodium bicarbonate, sodium carbonate, potassium bicarbonate, potassium carbonate, and ammonium bicarbonate, etc.

[0058] The oxidizer is: potassium chlorate, sodium chlorate, potassium perchlorate, sodium nitrate, potassium nitrate, potassium permanganate, potassium dichromate, etc. The fuming agent is: ammonium chloride, carbamate, rosin, cyanamide, ammonium bicarbonate, etc.

[0059] The flame retardant is: kaolin, clay, talc powder, limestone, gypsum, etc.

[0060] The cooling agent is: ammonium chloride, magnesium oxide, bentonite, white carbon black, diatomaceous earth, zinc oxide, etc.

[0061] The fuel is: wood powder, charcoal, white sugar, sucrose, thiourea, ammonium thiocyanate, cellulose, urea, hexamine, sulfur, coal powder, nitrocellulose, ginseng residue, etc.

[0062] The warning color is: inorganic pigments iron oxide, titanium oxide or Prussian blue; organic dyes such as alizarin, acid scarlet G, basic rose red, azo dyes, malachite green, brilliant green, light yellow, metal phthalocyanine or triphenylmethane dyes; it can also contain flavoring agents, such as natural aromatic oils.

[0063] The wall material is: natural polymer materials, such as: gelatin, gum arabic, agar, alginate, chitosan, fibrin, zein, etc.; semi-synthetic polymer materials, such as: methyl (ethyl) cellulose, carboxymethyl cellulose (sodium), cellulose acetate and its esters and partial glycerides, etc.; fully synthetic polymer materials, such as: polyacrylate resin, polylactic acid, melamine resin, urea-formaldehyde resin, polyamide, polyester, polymethyl methacrylate, polyurea, polyurethane, etc.

[0064] The attractant is: vegetable oil, animal fat, sweeteners, flavor enhancers, etc., such as ethylene glycol, sucrose, a mixture of cis-9-carbonene, trimethylamine and its hydrochloride, isovaleraldehyde, ethanol and its derivatives, furanone, luremone, etc.

[0065] The feeding stimulant is: linoleic acid, ammonium sulfate, fish meal, sucrose, borax, sodium dihydrogen phosphate, etc.

[0066] The preservatives are: Kathon, EQ, sodium benzoate, sodium dehydroacetate, sodium benzoate, BIT20, etc.

[0067] The fragrances are: liquid musk, lemon essence, lavender essence, tea tree essence, rose essence, etc.

[0068] The pesticidal preparation is applied at 10 to 1000 grams of active ingredient per hectare to the pests to be controlled or the medium on which they grow.

[0069] Use of a pesticidal preparation as described above for controlling pests in agriculture, forestry or public health.

[0070] The technical solution of the present invention further includes a method for controlling pests: applying the pesticidal preparation of the present invention to the pests or the medium on which they grow. The preferably selected amount of active ingredient is generally 10 grams to 1000 grams per hectare.

[0071] The technical solution of the present invention further includes the use of the above pesticidal preparation: the pesticidal preparation of the present invention can be applied to the control of pests in agriculture, forestry or public health for non-therapeutic purposes, and has excellent control effects on pests such as Lepidoptera, Coleoptera, Thysanoptera, etc., and is safe for crops.

[0072] The advantages of the present invention are:

[0073] Based on the particularity of the biological activity of pesticides themselves, guided by theoretical knowledge, and combined with comprehensive factors such as the purpose of use, control targets, application methods, and application conditions, by studying the structure-activity groups and modes of action of active ingredients, the appropriate adjuvant system and dosage are selected for the active ingredients, thereby improving the refinement level of the formulation. Specifically, it is reflected in: For the formulation prepared with the adjuvant system of the present invention, on the one hand, the adjuvant well anchors the active ingredients, so that the particles of the active ingredients are prevented from aggregating due to steric hindrance and electrostatic repulsion between the particles, thereby enabling the formulation system to obtain good physical stability, and can assist the active ingredients to be quickly, uniformly and stably dispersed in the spray carrier. The active ingredient has a small particle size and a narrow distribution, the viscosity of the liquid medicine is moderate, and the dynamic surface tension of the liquid medicine is appropriate, thereby ensuring the distribution and adhesion of the pesticide liquid medicine on the surface of the organism (plant leaf surface), promoting the absorption of the medicine by the organism, and even increasing the translocation of the medicine in the organism, reducing the loss of the liquid medicine, and achieving the purpose of increasing the retention amount of the pesticide on the plant surface, prolonging the retention time and improving the penetration ability of the plant epidermis; on the other hand, by controlling the contact angle range, improving its spreading and wetting ability, enabling the liquid medicine to directly enter the plant body from the stomata of the plant and be absorbed, ensuring the penetration and absorption of the liquid medicine, and further enabling the efficacy of the insecticide active ingredient obtained by the present invention to be fully improved. It can not only improve the control effect of the active ingredient of the pesticide, enhance its safety to crops, but also reduce the dosage, reduce costs, hit the target to the greatest extent with the least amount of medicine used, and improve the compatibility with the environment, reduce the harm of pesticides to the human body and environmental pollution. It is convenient to use, environmentally friendly, and convenient for production, transportation and storage. The insecticide composition of the present invention has a broad market prospect, as well as good economic, social and ecological benefits. Detailed implementation manners

[0074] The following specific examples are used to further illustrate the present invention in detail, but the present invention is by no means limited to these examples, and methods well known to those skilled in the art should be included within the scope of the present invention.

[0075] In all the formulations, the percentages and percentages in the ratios are by weight. The preparation of the active ingredient (as shown in General Formula I) can be obtained with reference to the relevant records in (CN 112457288 B).

[0076] Among them, the specific compounds in the compound shown in General Formula I are: Compound A1 (X 1 、X 2 are selected from F; X 3 is selected from Br; X 4 is selected from -CHF2; R is selected from H). Compound A2 (X 1 、X 2 are selected from F; X 3 is selected from Br; X 4Selected from -CHF2; R is selected from methyl). Compound A3 (X 1 、X 2 is selected from F; X 3 is selected from Br; X 4 is selected from -CHF2; R is selected from ethyl). Compound A4 (X 1 、X 2 is selected from F; X 3 is selected from Br; X 4 is selected from -CHF2; R is selected from n-propyl). All other raw materials are commercially available products.

[0077] Formulation Example

[0078] Example 1, Preparation of 5% Compound A1 Nano-suspension

[0079] According to the formulation requirements, 5% Compound A1, 2% dispersant SK-20TX, 5% dispersant SP-3219, 5% wetting agent Tensiofix D33, 1% silica white, 1% aluminum magnesium silicate, 0.2% xanthan gum, 0.3% preservative EQ, 0.8% defoamer SAG1522, 5% ethylene glycol, and water are added to the mixing tank in sequence to make up to 100% and mixed. First, it is coarsely pulverized and homogenized by high shear, and then pumped into a sand mill for fine grinding. The particle size of the sand-milled material is detected by a particle size distribution analyzer. After the particle size meets the standard requirements, it is filtered to obtain 5% Compound A1 nano-suspension.

[0080] A1 can also be replaced with one of the m-diamide insecticides (such as those shown in General Formula I) A2, A3, and A4 described in this specification to form new examples.

[0081] Example 2, Preparation of 20% Compound A1 Nano-suspension

[0082] According to the formulation requirements, 20% Compound A1, 3% dispersant SK-20TX, 5% dispersant SP-3275, 3% dispersant TENSIOFIX DB08, 0.8% silica white, 0.8% aluminum magnesium silicate, 0.15% xanthan gum, 0.2% preservative EQ, 0.6% defoamer SAG1522, 5% ethylene glycol, and water are added to the mixing tank in sequence to make up to 100% and mixed. First, it is coarsely pulverized and homogenized by high shear, and then pumped into a sand mill for fine grinding. The particle size of the sand-milled material is detected by a particle size distribution analyzer. After the particle size meets the standard requirements, it is filtered to obtain 20% Compound A1 nano-suspension.

[0083] A1 can also be replaced with one of the m-diamide insecticides (such as those shown in General Formula I) A2, A3, and A4 described in this specification to form new examples.

[0084] Preparation of 30% Compound A1 Nano-suspension

[0085] According to the formula requirements, 30% Compound A1, 4% dispersant SD811, 4% dispersant SP-NS5324, 5% penetrant anhydrous fast T-80J, 0.6% white carbon black, 0.6% magnesium aluminum silicate, 0.5% xanthan gum, 0.2% preservative Kathon, 0.6% defoamer SAG1522, 5% 1,2-propanediol, and water are added to the mixing tank in sequence to make up to 100% and mixed. First, it is coarsely pulverized and homogenized by high shear, then pumped into a sand mill for fine grinding. The particle size of the sand-milled material is detected by a particle size distribution analyzer. After the particle size meets the standard requirements, it is filtered to obtain 30% Compound A1 nano-suspension.

[0086] A1 can also be replaced with one of the m-diamide insecticides (such as those shown in General Formula I) A2, A3, and A4 described in this specification to form new examples.

[0087] Preparation of 40% Compound A1 Nano-suspension

[0088] According to the formula requirements, 40% Compound A1, 3% dispersant SK-20TX, 3% dispersant DURAMAX TM D-205, 5% wetting agent SP-3266E, 3% dispersant SP-NS5360, 0.6% white carbon black, 0.6% magnesium aluminum silicate, 0.08% xanthan gum, 0.2% preservative EQ, 0.6% defoamer SAG1522, 5% ethylene glycol, and water are added to the mixing tank in sequence to make up to 100% and mixed. First, it is coarsely pulverized and homogenized by high shear, then pumped into a sand mill for fine grinding. The particle size of the sand-milled material is detected by a particle size distribution analyzer. After the particle size meets the standard requirements, it is filtered to obtain 40% Compound A1 nano-suspension.

[0089] A1 can also be replaced with one of the m-diamide insecticides (such as those shown in General Formula I) A2, A3, and A4 described in this specification to form new examples.

[0090] Preparation of 50% Compound A1 Nano-suspension

[0091] According to the formulation requirements, 50% of compound A1, 3% of dispersant SK-24R, 3% of dispersant SK-20TX, 5% of dispersant SP-NS5366, 3% of dispersant TENSIOFIX DB08, 0.6% of silica white, 0.6% of magnesium aluminum silicate, 0.06% of xanthan gum, 0.2% of preservative Kathon, 0.6% of defoamer SAG1522, 5% of ethylene glycol, and water are added to 100% successively into the mixing tank for mixing. First, it is coarsely pulverized and homogenized by high shear, and then pumped into a sand mill for fine grinding. The particle size of the sand-ground material is detected by a particle size distribution analyzer. After the particle size reaches the standard requirements, it is filtered to obtain a 50% nano-suspension of compound A1.

[0092] A1 can also be replaced with one of the m-diamide insecticides (such as those shown in general formula I) A2, A3, and A4 described in this specification to form new examples.

[0093] Example 6. Preparation of 5% nano-emulsion of compound A1

[0094] According to the formulation requirements, 5% of compound A1, 8% of SP-3509, 4% of agricultural emulsion YUS-D935, 4% of agricultural emulsion 0201B, 10% of tributyl phosphate, 10% of dimethyl sulfoxide, 3% of propylene glycol, and 10% of xylene are added to the mixing kettle, stirred and mixed to dissolve into a uniform oil phase. Under high-speed stirring, the remaining water (made up to 100%) is added to the oil phase to obtain a 5% nano-emulsion of compound A1 with good dispersibility.

[0095] A1 can also be replaced with one of the m-diamide insecticides (such as those shown in general formula I) A2, A3, and A4 described in this specification to form new examples.

[0096] Example 7. Preparation of 20% nano-emulsion of compound A1

[0097] According to the formulation requirements, 20% of compound A1, 6% of emulsifier SP-ZR5210, 4% of emulsifier YUS-A51G, 5% of emulsifier 0201B, 10% of tributyl phosphate, 3% of propylene glycol, and 25% of Armid FMPC are added to the mixing kettle, stirred and mixed to dissolve into a uniform oil phase. Under high-speed stirring, the remaining water (made up to 100%) is added to the oil phase to obtain a 20% nano-emulsion of compound A1 with good dispersibility.

[0098] A1 can also be replaced with one of the m-diamide insecticides (such as those shown in general formula I) A2, A3, and A4 described in this specification to form new examples.

[0099] Example 8. Preparation of 30% nano-emulsion of compound A1

[0100] According to the formulation requirements, add 30% of compound A1, 7% of emulsifier SP-3509, 4% of emulsifier SK-5935, 4% of emulsifier 0201B, 10% of tributyl phosphate, 8% of dimethyl sulfoxide, 3% of glycerol, and 25% of Rhodiasolv Green 25 into the mixing kettle, stir and mix to dissolve into a homogeneous oil phase. Under high-speed stirring, add the remaining water (made up to 100%) to the oil phase to obtain a 30% compound A1 nano-emulsion with good dispersibility.

[0101] A1 can also be replaced with one of the m-diamide insecticides (such as those shown in general formula I) A2, A3, and A4 described in this specification to form a new embodiment.

[0102] Example 9. Preparation of 5% compound A1 nano-microemulsion

[0103] According to the formulation requirements, add 5% of compound A1, 6% of emulsifier YUS-A41B, 2% of emulsifier SP-ZR5210, 6% of emulsifier OX-8686, 5% of emulsifier 0201B, 3% of antifreeze ethylene glycol, 10% of Rhodiasolv Green SV-33, and 5% of cyclohexanone together, and dissolve them into a homogeneous oil phase. Make up the remaining amount with water to 100%. Under high-speed stirring, add the aqueous phase to the oil phase or add the oil phase to the aqueous phase to form a 5% compound A1 nano-microemulsion with good dispersibility.

[0104] A1 can also be replaced with one of the m-diamide insecticides (such as those shown in general formula I) A2, A3, and A4 described in this specification to form a new embodiment.

[0105] Example 10. Preparation of 10% compound A1 nano-microemulsion

[0106] According to the formulation requirements, add 10% of compound A1, 5% of emulsifier YUS-A51G, 2% of emulsifier SP-3509, 8% of emulsifier SK-5208T, 5% of emulsifier 0201B, 3% of antifreeze ethylene glycol, 5% of Rhodiasolv Green SV-92, and 5% of Armid FMPC together, and dissolve them into a homogeneous oil phase. Make up the remaining amount with water to 100%. Under high-speed stirring, add the aqueous phase to the oil phase or add the oil phase to the aqueous phase to form a 10% compound A1 nano-microemulsion with good dispersibility.

[0107] A1 can also be replaced with one of the m-diamide insecticides (such as those shown in general formula I) A2, A3, and A4 described in this specification to form a new embodiment.

[0108] Example 11. Preparation of 20% compound A1 nano-microemulsion

[0109] According to the formulation requirements, 20% of compound A1, 5% of emulsifier SP-ZR5210, 2% of emulsifier YUS-D625, 8% of emulsifier YUS-EC2200, 5% of emulsifier 0201B, 3% of antifreeze ethylene glycol, 5% of Rhodiasolv Green SV-92, and 5% of Armid DM10 are added together to dissolve into a uniform oil phase. The balance is made up to 100% with water. Under high-speed stirring, the aqueous phase is added to the oil phase or the oil phase is added to the aqueous phase to form a 20% nano microemulsion of compound A1 with good dispersibility.

[0110] A1 can also be replaced with one of the m-diamide insecticides (such as those shown in general formula I) A2, A3, and A4 described in this specification to form new examples.

[0111] Example 12. Preparation of 2% compound A1 nanoparticle agent

[0112] According to the formulation requirements, first add 2% of compound A1, 10% of N-methylpyrrolidone, 3% of agricultural emulsifier 0201B, 3% of agricultural emulsifier 0203B, and 6% of SP-3509 to the mixing kettle for dissolution, make up to 100% with silica sand and mix well, dry, and then coat with 1% chitosan aqueous solution and dry to obtain 2% compound A1 nanoparticle agent.

[0113] A1 can also be replaced with one of the m-diamide insecticides (such as those shown in general formula I) A2, A3, and A4 described in this specification to form new examples.

[0114] Example 13. Preparation of 30% compound A1 nanoparticle agent

[0115] According to the formulation requirements, 30% of compound A1, 7.5% of wetting agent sodium dodecyl sulfate, 6% of dispersant SP-3219, 6% of ammonium sulfate, 0.2% of silicone oil-based SAG1522 defoamer, 50.3% of kaolin, and 30% of water are successively added to the mixing tank for mixing. First, it is coarsely pulverized and homogenized by high shear, and then pumped into a sand mill for fine grinding. The particle size of the sand-milled material is detected with a particle size distribution analyzer. When the particle size meets the standard requirements, the suspension slurry is pumped into a spray dryer for drying and granulation. The spray pressure is controlled at 2-3 Mpa, the inlet air temperature for drying is 140 °C, and the outlet air temperature is 80 °C. The material after granulation is sieved to obtain 30% compound A1 nanoparticle agent.

[0116] A1 can also be replaced with one of the m-diamide insecticides (such as those shown in general formula I) A2, A3, and A4 described in this specification to form new examples.

[0117] Example 14. Preparation of 50% compound A1 nanoparticle agent

[0118] According to the formulation requirements, 50% of compound A1, 6% of dispersant SP-DF2222, 2% of dispersant SP-3275, 6% of wetting agent sodium dodecyl sulfate, 5% of ammonium sulfate, 0.2% of silicone oil-based SAG1522 defoamer, 30.8% of bentonite, and 30% of water are successively added to the mixing tank for mixing. First, it is coarsely pulverized and homogenized through high shear, and then pumped into a sand mill for fine grinding. The particle size of the sand-milled material is detected by a particle size distribution analyzer. When the particle size reaches the standard requirements, the suspension slurry is pumped into a spray dryer for drying and granulation. The spray pressure is controlled at 2 - 3 Mpa, the inlet drying temperature is 140 °C, and the outlet temperature is 80 °C. After granulation, the material is screened to obtain 50% compound A1 nanoparticle agent.

[0119] A1 can also be replaced with one of the m - diamide insecticides (such as those shown in general formula I) A2, A3, A4 described in this specification to form new examples.

[0120] Preparation of 20% compound A1 emulsifiable powder in Example 15

[0121] According to the formulation requirements, 20% of compound A1, 3% of emulsifier PICO-LOE, 5% of emulsifier OX-2681, 2% of emulsifier 1601#, 5% of emulsifier 0201B, 5% of N-methylpyrrolidone, and 15% of Rhodiasolv Green 25 are respectively added to the mixing kettle, stirred and mixed evenly, and dissolved by heating in a hot water bath if necessary. Under stirring conditions, the above oil base is evenly sprayed onto a mixture composed of 20% silica white and attapulgite supplemented to 100%. After being pulverized by an ultrafine pulverizer, 20% compound A1 emulsifiable powder is obtained.

[0122] A1 can also be replaced with one of the m - diamide insecticides (such as those shown in general formula I) A2, A3, A4 described in this specification to form new examples.

[0123] Preparation of 20% compound A1 emulsifiable granule in Example 16

[0124] According to the formulation requirements, 20% of compound A1, 2% of emulsifier S-80, 6% of emulsifier OX-2681, 4% of emulsifier 0201B, 2% of emulsifier OX-8686, 5% of N-methylpyrrolidone, and 15% of Rhodiasolv Green 25 are respectively added to the mixing kettle, stirred and mixed evenly, and dissolved by heating in a hot water bath if necessary. Under stirring conditions, the above oil base is evenly sprayed onto a mixture composed of 20% silica white and attapulgite supplemented to 100%. After being pulverized by an ultrafine pulverizer, it is then kneaded with water and added to a granulator equipped with a certain specification sieve for granulation. Then, after drying and screening (according to the sieve range), 20% compound A1 emulsifiable granule can be obtained.

[0125] A1 can also be replaced with one of the m - diamide insecticides (such as those shown in General Formula I) A2, A3, and A4 described in this specification to form new examples.

[0126] Example 17. Preparation of 5% Compound A1 Effervescent Granules

[0127] According to the formulation requirements, 5% Compound A1, 3% dispersant TANEMUL AG281, 3% dispersant PICO - SWP1, 2% sodium methylnaphthalenesulfonate formaldehyde condensate, 1% sodium dodecyl sulfate, 20% soluble starch, 15% citric acid, 15% sodium bicarbonate, 10% sodium sulfate, and kieselguhr are added to make up 100% and mixed thoroughly. After being pulverized by an ultrafine pulverizer, and then kneaded and granulated, 5% Compound A1 effervescent granules can be obtained.

[0128] A1 can also be replaced with one of the m - diamide insecticides (such as those shown in General Formula I) A2, A3, and A4 described in this specification to form new examples.

[0129] Example 18. Preparation of 20% Compound A1 Effervescent Granules

[0130] According to the formulation requirements, 20% Compound A1, 4% sodium salt of alkylnaphthalenesulfonic acid condensate, 2% sodium methylnaphthalenesulfonate formaldehyde condensate, 1% wetting agent YUS - A51G, 20% soluble starch, 15% citric acid, 15% sodium bicarbonate, 10% sodium sulfate, and kieselguhr are added to make up 100% and mixed thoroughly. After being pulverized by an ultrafine pulverizer, and then kneaded and granulated, 20% Compound A1 effervescent granules can be obtained.

[0131] A1 can also be replaced with one of the m - diamide insecticides (such as those shown in General Formula I) A2, A3, and A4 described in this specification to form new examples.

[0132] Example 19. Preparation of 2% Compound A1 Effervescent Tablets

[0133] According to the formulation requirements, 2% Compound A1, 4% dispersant Supragil MNS / 90, 3% dispersant PICO - SWP1, 2% sodium methylnaphthalenesulfonate formaldehyde condensate, 1% sodium dodecyl sulfate, 20% soluble starch, 15% citric acid, 15% sodium bicarbonate, 10% sodium sulfate, and kieselguhr are added to make up 100% and mixed thoroughly. After being pulverized by an ultrafine pulverizer, and then pressed into tablets, 2% Compound A1 effervescent tablets can be obtained.

[0134] A1 can also be replaced with one of the m - diamide insecticides (such as those shown in General Formula I) A2, A3, and A4 described in this specification to form new examples.

[0135] Example 20: Preparation of 0.5% Compound A1 Aerosol

[0136] According to the formulation requirements, 0.5% Compound A1, 10% acetophenone, and 84.5% methylnaphthalene are placed in a container with stirring. After stirring until a homogeneous and transparent solution is obtained, 2.5% castor oil polyoxyethylene ether, 0.5% calcium dodecylbenzenesulfonate, 1% azone, and 1% triphenyl phosphate are added, and stirred thoroughly to form a homogeneous and transparent oil phase, thus obtaining 0.5% Compound A1 aerosol.

[0137] A1 can also be replaced with one of the m-diamide insecticides (such as those shown in General Formula I) A2, A3, and A4 described in this specification to form new examples.

[0138] Example 21: Preparation of 1% Compound A1 Thermal Fogging Agent

[0139] According to the formulation requirements, 1% Compound A1, 2% azone, 6% fatty alcohol polyoxyethylene ether, 3% calcium dodecylbenzenesulfonate, 4% triphenyl phosphate, 5% N-methylpyrrolidone, and 15% soybean oil are used, and methylnaphthalene is added to make up to 100%. Stir thoroughly to form a homogeneous and transparent oil phase, thus obtaining 1% Compound A1 thermal fogging agent.

[0140] A1 can also be replaced with one of the m-diamide insecticides (such as those shown in General Formula I) A2, A3, and A4 described in this specification to form new examples.

[0141] Example 22: Preparation of 2% Compound A1 Thermal Fogging Agent

[0142] According to the formulation requirements, 2% Compound A1, 2% azone, 8% fatty alcohol polyoxyethylene ether, 5% calcium dodecylbenzenesulfonate, 10% triphenyl phosphate, 12% benzyl alcohol, and 20% methyl oleate are used, and methylnaphthalene is added to make up to 100%. Stir thoroughly to form a homogeneous and transparent oil phase, thus obtaining 2% Compound A1 thermal fogging agent.

[0143] A1 can also be replaced with one of the m-diamide insecticides (such as those shown in General Formula I) A2, A3, and A4 described in this specification to form new examples.

[0144] Example 23: Preparation of 2% Compound A1 Tablets

[0145] According to the formulation requirements, 2% Compound A1, 2% dispersant SK-24R, 1% wetting agent sodium dodecyl sulfate, 4% dispersant Supragil MNS / 90, 20% soluble starch, 10% sodium sulfate, 5% white carbon black, and diatomaceous earth are added to make up to 100% and mixed thoroughly. After being pulverized by an ultrafine pulverizer, tablets are pressed, thus obtaining 2% Compound A1 tablets.

[0146] A1 can also be replaced with one of the m - diamide insecticides (such as those shown in General Formula I) A2, A3, or A4 described in this specification to form new embodiments.

[0147] Example 24. Preparation of 10% Compound A1 Tablets

[0148] According to the formulation requirements, mix 10% Compound A1, 3% dispersant sodium methylnaphthalenesulfonate formaldehyde condensate, 4% dispersant PICO - SF1, 1% emulsifier YUS - A51G, 3% dispersant TANEMUL DA266, 20% soluble starch, 10% sodium sulfate, 5% white carbon black, and diatomaceous earth to make up to 100% and mix thoroughly. After pulverizing with an ultrafine pulverizer, press into tablets to obtain 10% Compound A1 tablets.

[0149] A1 can also be replaced with one of the m - diamide insecticides (such as those shown in General Formula I) A2, A3, or A4 described in this specification to form new embodiments.

[0150] Example 25. Preparation of 5% Compound A1 Micro - encapsulated Granules

[0151] According to the formulation requirements, add 5% Compound A1, 2% calcium lignosulfonate, 2% dispersant sodium alkylnaphthalenesulfonate condensate, 3% sodium methylnaphthalenesulfonate formaldehyde condensate, 1% wetting agent TENSIOFIX BCZ, 5% white carbon black, 5% carboxymethyl starch sodium, 1% 1% water - soluble chitosan, and bentonite to make up to 100% and mix and pulverize. Then, after kneading with water, add it to a granulator equipped with a certain - sized sieve for granulation. Then, dry and screen (according to the sieve range), and then coat with 1% 1% water - soluble chitosan and air - dry to obtain 5% Compound A1 micro - encapsulated granules.

[0152] A1 can also be replaced with one of the m - diamide insecticides (such as those shown in General Formula I) A2, A3, or A4 described in this specification to form new embodiments.

[0153] Example 26. Preparation of 40% Compound A1 Micro - encapsulated Granules

[0154] In a 1000 - milliliter plastic (with baffle) bottle, add 600 milliliters of 0.5% polyvinyl alcohol aqueous solution. Using a tetrafluoroethylene stirrer, add 20 grams of Compound A, 9 grams of ethylene oxide - propylene oxide block copolymer, 6 grams of epoxidized soybean oil, 3 grams of diphenylmethane - 4,4 - diisocyanate, 1.5 grams of ethylenediamine, 5 grams of sodium carbonate, and 150 milliliters of water under high - speed stirring. After adding all the materials, slow down the speed and continue stirring for 1 hour, let stand for 1 hour, filter, and dry in vacuum to obtain 40% Compound A1 micro - encapsulated granules.

[0155] A1 may also be replaced with one of the diamide insecticides (as shown in general formula I) A2, A3, and A4 described in this specification to form a new embodiment.

[0156] Example 27: Preparation of 20% Compound A1 Microcapsule Suspension

[0157] According to the formula requirements, a certain ratio of urea and 37%-40% formaldehyde aqueous solution (formaldehyde: water = 1:1.75 v / v) and an appropriate amount of water were weighed and added into a three-necked flask respectively, and the pH value of the system was adjusted to 8-9 with 10% sodium hydroxide. Under the condition of stirring at 200 r / min, the temperature was heated to 70°C and reacted for 1.5 hours to obtain a urea-formaldehyde resin prepolymer (UF) aqueous solution. At room temperature, 20.5 g of compound A1 was dissolved in a beaker with 3 g of N-methylpyrrolidone and 2.0 g of a mixed solution of xylene, and an appropriate amount of 5% styrene maleic anhydride and a few drops of defoamer SAG1522 were added. After sufficient stirring, 18 g of UF aqueous solution was added, and the mixture was stirred at 2500 r / min for 30 min to form a stable O / W emulsion. The mixture was stirred at 1000 r / min, and 10% hydrochloric acid was slowly added to adjust the pH value of the system. When the pH value dropped to 2.0, the rotation speed was reduced to 200 r / min, the temperature was raised to 60°C, and after curing for 5 h, 10% sodium hydroxide was used to adjust the pH value of the system to 7, and water was added to make up to 100 g and stirred evenly to obtain a 20% compound A1 microcapsule suspension.

[0158] A1 may also be replaced with one of the diamide insecticides (as shown in general formula I) A2, A3, and A4 described in this specification to form a new embodiment.

[0159] Example 28: Preparation of 2% Compound A1 Electrostatic Spray

[0160] According to the formula requirements, 2% compound A1, 20% ethylene glycol methyl ether, 2% Nongru 0201B, 1% Nongru OX-8686, and dibutyl phthalate are added to a mixing kettle to make up to 100%, and stirred to mix evenly. If necessary, heat in a hot water bath to dissolve, and then a 2% compound A1 electrostatic spray can be obtained.

[0161] A1 may also be replaced with one of the diamide insecticides (as shown in general formula I) A2, A3, and A4 described in this specification to form a new embodiment.

[0162] Example 29: Preparation of 10% Compound A1 Smoke Agent

[0163] Compound A1 and various auxiliaries are respectively pulverized to 80 - 100 meshes. According to the formulation requirements, 10% of compound A1, 11% of ammonium chloride, 15% of sodium chlorate, 3% of carboxymethyl cellulose, 8% of kaolin, 29% of talcum powder, and the balance of wood powder to make 100% are mixed. The materials mixed according to the above formulation ratio are put into a plastic bag, and then are externally packaged with heat-insulating poor conductors such as hard paper tubes or bamboo tubes, plain earth jars, and earthenware jars. The lead wires are buried in the smoke agent, and the spray ports are placed on the upper part or the side part. The joints and the smoke holes are sealed firmly with wax paper, and then 10% compound A1 smoke agent can be obtained. When in use, just tear off the paper strip at the smoke hole.

[0164] A1 can also be replaced with one of the m - diamide insecticides (such as those shown in general formula I) A2, A3, and A4 described in this specification to form new embodiments.

[0165] Example 30. Preparation of 0.5% Compound A1 Bait

[0166] Compound A1 is pulverized. According to the formulation requirements, 0.5% of compound A1, 1% of linoleic acid, 5% of trimethylamine hydrochloride, 5% of ammonium sulfate, and the balance of fish meal to make 100% are mixed. After mixing evenly, 0.5% compound A1 bait can be obtained.

[0167] A1 can also be replaced with one of the m - diamide insecticides (such as those shown in general formula I) A2, A3, and A4 described in this specification to form new embodiments.

[0168] Example 31. Preparation of 0.3% Compound A1 Bait

[0169] Compound A1 is pulverized. According to the formulation requirements, 0.3% of compound A1, 50% of sucrose, and the balance of borax to make 100% are mixed. After mixing evenly, 0.3% compound A1 bait can be obtained.

[0170] A1 can also be replaced with one of the m - diamide insecticides (such as those shown in general formula I) A2, A3, and A4 described in this specification to form new embodiments.

[0171] Example 32. Preparation of 0.1% Compound A1 Coil Incense

[0172] According to the formula requirements, 0.1% of compound A1 (pre-dispersed), 0.4% of malachite green, 0.3% of liquid musk, 10% of elm bark powder, 2% of soluble starch, 0.2% of sodium benzoate, and the balance is made up with wood powder to 100%. Preparation process: First, mix compound A1 with wood powder, then add elm bark powder and soluble starch, and mix them evenly by a blender. Then, feed this mixed powder into a kneading machine, and at the same time add malachite green, liquid musk, and sodium benzoate, and add water while stirring until it becomes a dough-like state. Then, extrude the mosquito-repellent incense mixture into strip-shaped mosquito-repellent incense fragrance by an extruder, cut it at regular intervals, and then punch out spiral-shaped mosquito-repellent incense blanks by a stamping machine. Dry the moisture in a dryer to obtain 0.1% compound A1 coil mosquito-repellent incense.

[0173] A1 can also be replaced with one of the m-diamide insecticides (such as those shown in general formula I) A2, A3, and A4 described in this specification to form new embodiments.

[0174] Example 33. Preparation of 0.3% compound A1 coil mosquito-repellent incense

[0175] According to the formula requirements, 0.3% of compound A1 (pre-dispersed), 0.4% of malachite green, 0.3% of liquid musk, 1% of potassium nitrate, 8% of Artemisia annua, 3% of soluble starch, 0.2% of sodium benzoate, and the balance is made up with wood powder to 100%. Preparation process: First, mix compound A1 with wood powder, then add elm bark powder and soluble starch, and mix them evenly by a blender. Then, feed this mixed powder into a kneading machine, and at the same time add malachite green, liquid musk, and sodium benzoate, and add water while stirring until it becomes a dough-like state. Then, extrude the mosquito-repellent incense mixture into strip-shaped mosquito-repellent incense fragrance by an extruder, cut it at regular intervals, and then punch out spiral-shaped mosquito-repellent incense blanks by a stamping machine. Dry the moisture in a dryer to obtain 0.3% compound A1 coil mosquito-repellent incense.

[0176] A1 can also be replaced with one of the m-diamide insecticides (such as those shown in general formula I) A2, A3, and A4 described in this specification to form new embodiments.

[0177] Example 34. Preparation of 0.1% compound A1 electric heating liquid mosquito-repellent incense

[0178] According to the formula requirements, 0.1% of compound A1, 20% of butyl butyrate, 18% of eucalyptus oil, 0.2% of sodium benzoate, 2% of isopropyl myristate, and the balance is ethanol. After fully mixing and stirring evenly, it is filled into a bottle to obtain 0.1% compound A1 electric heating liquid mosquito-repellent incense.

[0179] A1 can also be replaced with one of the m-diamide insecticides (such as those shown in general formula I) A2, A3, and A4 described in this specification to form new embodiments.

[0180] Example 35: Preparation of 0.3% Compound A1 Electrothermal Liquid Mosquito Repellent Coil

[0181] According to the formula requirements, 0.3% compound A1, 15% butyl butyrate, 18% eucalyptus oil, 15% sodium sulfate of fatty alcohol polyoxyethylene ether, 0.1% sodium benzoate, 1% isopropyl myristate, and the remainder ethanol are fully mixed and stirred to disperse evenly, and then filled into a bottle to obtain a 0.3% compound A1 electric heated liquid mosquito coil.

[0182] A1 may also be replaced with one of the diamide insecticides (as shown in general formula I) A2, A3, and A4 described in this specification to form a new embodiment.

[0183] Biological Activity Test Example

[0184] Indoor activity test

[0185] The test targets are Plutella xylostella, Ostrinia furnacnlisGuenee, Spodoptera exigua Hübner and Mythimna seperata, all of which are sensitive species raised indoors all year round. The test conditions are temperature: 24-26°C, humidity: RH 60%, light: L:D=14:10. The test preparations are accurately weighed using an electronic analytical balance and diluted with water to the required concentration. The test adopts the airbrush spray method for treatment. Cabbage leaves grown in the greenhouse are retrieved and made into leaf discs with a diameter of 2 cm. The pressure of the airbrush spray treatment is 10 psi (about 0.7 kg / cm 2 ), spray each leaf disc on both sides, the spray volume is 0.5mL, after drying in the shade, put it in a 9cm culture dish padded with filter paper, select neat and consistent test insects and put them into the culture dish, and repeat 4 times for each treatment. The treated test insects are placed in the observation room, and the reaction of the test insects is observed regularly, the number of dead and alive insects is investigated, and the mortality rate is calculated. The results of the indoor activity test of some embodiments are shown in Tables 1 to 4. At the same time, CK is compound A1.

[0186] Table 1 Results of indoor activity test of different preparations against corn borer

[0187]

[0188] Table 2 Results of indoor activity test of different preparations against Spodoptera exigua

[0189]

[0190] Table 3 Results of indoor activity test of the preparation samples against Plutella xylostella

[0191]

[0192] Table 4 Results of indoor bioactivity determination of the formulated samples against Mythimna separata

[0193]

[0194] From the test result data in Tables 1 - 4, it can be seen that for the specific formulated samples prepared in each example, the bioactivity against Ostrinia furnacalis, Mythimna separata, Plutella xylostella, and Spodoptera exigua is higher than or equivalent to that of the technical material.

[0195] The formulated products developed in the present invention have an appropriate dynamic surface tension. The liquid medicine can spread, wet, and adhere well on the target, with a long retention time, thereby promoting the rapid conduction of the active ingredient and enhancing the biological activity of the active component. The formulated products prepared by the present invention not only enhance the biological activity, reduce the dosage of the medicine, and lower the cost, hitting the target to the maximum extent with the least amount of medicine used, but also improve the compatibility with the environment. All the formulated products obtained in the present invention can be used as insecticides for controlling pests in agriculture, forestry, or public health, and are safe for crops.

[0196] The content not described in detail in this specification belongs to the prior art well-known to those skilled in the art.

Claims

1. An insecticide containing a m-diamide compound, characterized in that: The insecticide contains a meta-diamide compound represented by the general formula I, at least one carrier and at least one surfactant; wherein, the weight percentage of the meta-diamide compound represented by the general formula I is 0.1-99%; The structure of the meta-diamide compound represented by the general formula I is as follows: In the formula: X 1 、 X 3 may be the same or different and are selected from halogen; X 2 selected from H or a halogen; X 4 selected from halo C1-C3 alkyl; R is selected from H, C1-C6 alkyl, and halogenated C1-C6 alkyl.

2. The pesticide according to claim 1, characterized in that: In the general formula I: X 1 selected from F; X 2 selected from H or F; X 3 selected from Cl, Br, I; X 4 selected from -CF3, -CHF2; R is selected from H, C1-C6 alkyl.

3. The insecticide according to claim 2, characterized in that: In the general formula I: X 1 and X 2 is selected from F; X 3 Selected from Br; X 4 selected from -CHF2; R is selected from H, C1-C6 alkyl.

4. The insecticide according to claim 3, characterized in that: In the general formula I: X 1 、X 2 selected from F; X 3 selected from Br; X 4 selected from -CHF2; R is selected from H, methyl, ethyl, and n-propyl.

5. The insecticidal preparation according to any one of claims 1-4, characterized in that: The insecticide is a nano-suspension, nano-emulsion, nano-microemulsion, nano-granule, electrostatic spray, thermal fogging agent, aerosol, emulsifiable powder (granule) agent, effervescent tablet (granule) agent, tablet, smoke agent, bait agent, coil mosquito repellent, electric heating liquid mosquito repellent, microcapsule suspension, and microcapsule granule.

6. The insecticidal preparation according to claim 5, characterized in that, The insecticidal preparation according to claim 1 is applied at 10-1000 g of active ingredient per hectare to the pests to be controlled or the medium on which they grow.

7. Use of the insecticidal preparation according to claim 1 in controlling pests in agriculture, forestry or public health.

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