Tabletting preparation process of pet hair ball tablet containing natural fibers

Abstract

The invention relates to the technical field of pet food processing, and particularly discloses a tabletting preparation process of pet hair ball tablets containing natural fibers, which comprises the following steps: firstly, carrying out low-temperature crushing pretreatment on natural fiber raw materials to guarantee the fineness of the raw materials; next, embedding the probiotic freeze-dried powder and the fish oil microcapsules by using a sodium alginate solution to form active particles, and retaining the activity of beneficial components; when the ingredients are mixed, auxiliary materials such as pregelatinized starch and calcium carbonate are accurately added under the protection of high-purity nitrogen and are fully stirred. The wet granulation takes a specific hydroxypropyl methyl cellulose ethanol solution as a wetting agent, and ultrasonic vibration is combined to ensure uniformity. And carrying out segmented temperature control drying by a fluidized bed, and tabletting and forming by a high-speed rotary tablet press, wherein a punch is provided with a nano ceramic coating for preventing adhesion. Then double-layer coating, plasticizer adding, polymer molecular weight regulating and controlling to optimize the coating effect, low-temperature light-proof curing and finally aluminum-plastic blister packaging with the high nitrogen replacement rate are conducted, the product quality and effect are guaranteed, and healthy hair formation of pets is facilitated.

Description

Technical Field

[0001] The invention relates to the technical field of pet food processing, in particular to a tabletting preparation process of a pet hair ball sheet containing natural fibers. Background Art

[0002] As people's living standards improve, pet keeping becomes more and more popular. Pets play an increasingly important role in people's lives and become important members of the family. When pets such as cats and some dogs lick their fur, they will inevitably swallow a lot of hair into their bodies. These hairs are difficult to be completely decomposed by the pet's digestive system. Over time, they are easy to accumulate in the gastrointestinal tract to form hairballs, causing health problems such as vomiting, loss of appetite, indigestion and even intestinal obstruction, which seriously affects the quality of life and life span of pets.

[0003] Traditional methods of dealing with pet hairball problems include feeding cat grass, but cat grass is time-consuming and laborious to grow, and is greatly restricted by factors such as season and growing environment, and some pets are not very receptive to it. Another method is to use hairball remover cream, but hairball remover cream usually contains more oil ingredients. Long-term or excessive consumption may cause pets to suffer from obesity, diarrhea and other adverse conditions, posing potential risks to their health.

[0004] In recent years, the pet health care product market has been booming, and pet hairball removal products are an important branch of the market. Consumers are increasingly demanding on their quality, safety, and effectiveness. The market is in urgent need of a hairball removal product that can effectively help pets expel hairballs and is natural, healthy, and easily accepted by pets.

[0005] In the field of pet food and health care product research and development, the use of natural fibers to promote intestinal peristalsis and carry hair out of the body has become an important direction. Natural fibers have many advantages such as wide sources, high safety, and not easy to cause adverse reactions. For example, alfalfa fiber is rich in dietary fiber, which can increase the volume of feces, promote mechanical peristalsis of the intestine, and help hair discharge; oat fiber has good water absorption and can form a soft gel-like substance in the intestine to wrap the hair and reduce the irritation of hair balls to the intestine; pumpkin fiber is rich in pectin and other ingredients, which can regulate intestinal flora and synergistically play the role of hair removal. The rational use of these natural fibers in pet hair removal products is expected to solve many drawbacks of traditional hair removal methods.

[0006] At the same time, the progress of modern pharmaceutical and food processing technology has provided technical support for the refined preparation of pet health products. Spray encapsulation technology can effectively protect active ingredients such as probiotics and fish oil, so that they remain active during storage and can smoothly reach the pet's intestines to play a role. For example, probiotics help maintain the balance of intestinal microecology, enhance digestion, and complement the hair removal process; fish oil is rich in unsaturated fatty acids, which is beneficial to the health of pets' hair, reduces hair loss, and reduces the pressure of hairball formation from the root. Process steps such as wet granulation, fluidized bed drying, double-layer coating, and low-temperature curing can ensure the molding quality, stability and palatability of the product to meet the needs of pets.

[0007] In addition, in the packaging process, the aluminum-plastic blister packaging and nitrogen filling can not only effectively isolate oxygen and moisture, prevent the product from oxidation, deterioration and deliquescence, and extend the shelf life, but also provide a good protective barrier for the product during storage and transportation, ensuring that pet owners buy reliable quality products. In summary, the development of a tableting process for pet hair ball tablets containing natural fibers has important practical significance and broad market prospects. Summary of the invention

[0008] 1. Technical issues to be resolved In view of the shortcomings of the prior art, the present invention provides a process for preparing a pet-like hair ball sheet containing natural fibers, which solves the problems raised in the above-mentioned background technology.

[0009] (II) Technical solution In order to achieve the above-mentioned object, the present invention discloses a process for preparing a pet-like hair ball sheet containing natural fibers, comprising the following steps: Step 1: Pretreatment of fiber raw materials: Place the natural fiber raw materials in a low-temperature pulverizer, control the pulverization temperature to ≤15°C, pulverize for 8-12 minutes, and pass through a 80-120 mesh sieve after pulverization to obtain fiber powder with a particle size of ≤200μm; Step 2, active ingredient embedding: weigh 30-50 parts of fiber powder, 5-10 parts of probiotic freeze-dried powder, and 3-8 parts of fish oil microcapsules by weight, mix the probiotic freeze-dried powder and the fish oil microcapsules, and use spray embedding technology with sodium alginate solution as an embedding agent to form active particles with a particle size of 50-150 μm; Step 3, mixing ingredients: add fiber powder and active particles into a mixer, add 20-30 parts of pregelatinized starch, 5-10 parts of calcium carbonate, and 10-15 parts of maltodextrin in sequence, stir at 20-40r / min for 15-25 minutes under nitrogen protection, then add 2-4 parts of micro powder silica gel and 1-2 parts of magnesium stearate, and continue mixing for 5-8 minutes; Step 4, Wet Granulation: Using an ethanol solution containing 1%-3% hydroxypropyl methylcellulose as the wetting agent, spray it evenly through a high-pressure atomizing spray gun. The dosage of the wetting agent is 10%-15% of the total weight of the mixture, and the spray pressure is 0.2-0.4 MPa. After wetting, transfer it to a wet granulator and granulate at a shear speed of 150-250 r / min for 8-12 minutes to obtain wet granules with a particle size of 0.8-1.5 mm. Step 5, Fluidized Bed Drying: Place the wet granules in a fluidized bed, set the inlet air temperature at 30-35 °C, the wind speed at 1.0-1.8 m³ / s, and dry until the water content ≤ 2.5%. Step 6, Tabletting: Add the dried granules to a high-speed rotary tabletting machine, set the tabletting pressure at 8-12 kN, the die diameter at 10-15 mm, coat the surface of the punch with a nano-ceramic coating, and the die gap at 0.03-0.08 mm to press out the tablet core. Step 7, Double-layer Coating: The inner coating solution is an ethanol solution containing 5%-10% shellac, and the outer coating solution is a composite aqueous solution containing 2%-4% polyvinyl alcohol and 1%-2% beeswax. The coating weight gains are 0.5%-1.5% and 2%-4% of the weight of the tablet core respectively, and the atomization particle size is controlled at 30-60 μm. Step 8, Low-temperature Curing: Place the coated tablets in a light-proof constant-temperature box at a temperature of 18-22 °C, a humidity of 25%-35%, and a curing time of 36-48 hours. Step 9, Sub-packaging: Use an aluminum-plastic blister packaging machine for sub-packaging, fill with nitrogen protective gas, and the sealing temperature is 120-150 °C.

[0010] Preferably, in Step 1, the natural fiber is at least one of alfalfa fiber, oat fiber, or pumpkin fiber. The temperature of the pulverizer cavity is maintained at 10-12 °C, and the nitrogen circulation cooling system operates continuously.

[0011] Preferably, in Step 2, the technical parameters of the spray embedding are: the concentration of the sodium alginate solution is 3%-5%, the atomization pressure is 0.15-0.25 MPa, and the inlet air temperature is 40-45 °C.

[0012] Preferably, in Step 3, the nitrogen purity ≥ 99.95%, the internal air pressure of the mixer is maintained at 0.05-0.15 MPa, the rotation speed ratio of the stirring paddle to the cutting knife is 3:1, and the rotation speed of the cutting knife is 80-120 r / min.

[0013] Preferably, in Step 4, the ethanol concentration of the hydroxypropyl methylcellulose ethanol solution is 70%-80%. When spraying the wetting agent, the ultrasonic vibration device is turned on synchronously, and the frequency is 20-40 kHz.

[0014] Preferably, in step 5, the fluidized bed dryer adopts a segmented temperature control mode, with the inlet air temperature being 28-30° C. in the initial stage and increasing to 32-35° C. in the later stage, and the total drying time being 20-30 minutes.

[0015] Preferably, in step six, the thickness of the nano-ceramic coating is 0.1-0.3 μm, and the surface roughness of the tablet press punch is Ra≤0.05 μm.

[0016] Preferably, in step seven, 0.1%-0.5% citric acid is added to the inner coating solution as a plasticizer, and the molecular weight of the polyvinyl alcohol in the outer coating solution is 10,000-30,000 Da.

[0017] Preferably, the constant temperature box in step eight is equipped with a temperature and humidity feedback control system, with temperature fluctuation ≤±0.5°C and humidity fluctuation ≤±3%.

[0018] Preferably, in step nine, the nitrogen replacement rate of the aluminum-plastic blister packaging is 95%-98%, and the sealing pressure is 0.3-0.5 MPa.

[0019] 3. Beneficial technical effects This process uses natural fibers such as alfalfa fiber, oat fiber or pumpkin fiber, which are widely available and highly safe, and are not likely to cause adverse reactions to pets like traditional hair removal products. Alfalfa fiber is rich in dietary fiber, which can effectively increase the volume of feces and strongly promote intestinal mechanical peristalsis, just like paving a "fast track" for the movement of hair in the intestine, helping the hair to be discharged smoothly from the body, and effectively reducing the accumulation of hair balls in the gastrointestinal tract. With its good water absorption, oat fiber can magically form soft gel-like substances in the intestine. These gels are like gentle guards, tightly wrapping the hair, greatly reducing the stimulation of hair balls on the intestinal mucosa, reducing the risk of intestinal damage, and maintaining a healthy intestinal environment. Pumpkin fiber is rich in pectin and other ingredients, which can cleverly regulate intestinal flora, optimize intestinal microecology, and work together with other fibers to fully exert the effect of hair removal, fundamentally addressing the health risks caused by pets swallowing hair.

[0020] In the fiber raw material pretreatment stage, the natural fiber raw material is placed in a low-temperature pulverizer, the pulverization temperature is strictly controlled to be ≤15℃, the pulverization time is 8-12 minutes, and after pulverization, it is passed through an 80-120 mesh sieve to obtain fiber powder with a particle size of ≤200μm. This fine treatment ensures that the fiber powder has a suitable particle size and physical properties, so that it can be evenly dispersed in the subsequent ingredient mixing and granulation processes, fully interact with other ingredients, and maximize the function of promoting intestinal peristalsis and entraining hair, so that every hair that may form a hair ball has nowhere to hide.

[0021] With natural fibers as the core ingredient, it abandons the relatively high oil content in traditional hairball creams, avoiding adverse conditions such as obesity and diarrhea after long-term or excessive consumption by pets, safeguarding the healthy body shape of pets, and escorting the long-term healthy life of pets. These natural fibers all come from the gifts of nature, meeting the pursuit of pet owners for natural and additive-free pet food, enabling pets to enjoy hairball care without ingesting excessive harmful chemicals or unhealthy fats, and ensuring the normal operation of the pet's body functions.

[0022] During the entire preparation process, no artificial pigments, flavors, or preservatives harmful to pet health are added. From raw material selection to finished product packaging, the principle of natural health is strictly followed to ensure that the pet hairball tablets are pure and pollution-free. Even pets with sensitive constitutions can eat them with confidence, providing all-round health protection for pets and allowing pet owners not to worry about potential health crises that hairball products may bring to pets.

[0023] In the ingredient mixing link, 20 - 30 parts of pregelatinized starch and 10 - 15 parts of maltodextrin are carefully added. These ingredients can not only assist in shaping, but more importantly, can improve the product taste, making it have an appropriate sweetness and viscosity to meet the taste preferences of pets. At the same time, the addition of 2 - 4 parts of microcrystalline silica can further optimize the fluidity and dispersibility of the product, making the pet's eating experience smoother, avoiding the situation of resistance to eating due to poor taste, and increasing the pet's willingness to actively ingest the hairball tablets.

[0024] The double-layer coating technology is adopted. The inner coating solution is an ethanol solution containing 5% - 10% shellac, and the outer coating solution is a composite aqueous solution containing 2% - 4% polyvinyl alcohol and 1% - 2% beeswax. The coating weight gains are 0.5% - 1.5% and 2% - 4% of the tablet core weight respectively, and the atomization particle size is controlled at 30 - 60μm. This delicate coating not only provides good moisture-proof and anti-oxidation protection for the hairball tablets, extending the shelf life, but also gives the product a smooth and beautiful appearance, attracting pets both visually and gustatorily, making pets regard the hairball tablets as delicious snacks and easily solving the pet feeding problem.

[0025] The spray embedding technology is used to process the freeze-dried probiotics and fish oil microcapsules, with sodium alginate solution as the embedding agent, to form active particles with a particle size of 50 - 150μm. In this process, the spray embedding technology parameters are precisely set, the concentration of sodium alginate solution is 3% - 5%, the atomization pressure is 0.15 - 0.25MPa, and the inlet air temperature is 40 - 45°C, ensuring that active ingredients such as probiotics and fish oil remain active during storage and can reach the pet's intestine smoothly to play a role. Probiotics help maintain the balance of the intestinal microecosystem, enhance digestive function, closely cooperate with the hairball removal process, form a virtuous cycle, and further improve the digestive health level of pets; fish oil is rich in unsaturated fatty acids, which is beneficial to the hair health of pets, reduces hair loss from the root, relieves the pressure of hairball formation, makes the pet's hair more bright and smooth, and takes care of the pet's health both inside and out.

[0026] In the wet granulation process, an ethanol solution containing 1% - 3% hydroxypropyl methylcellulose is used as the wetting agent, which is evenly sprayed through a high-pressure atomizing spray gun. The dosage of the wetting agent is 10% - 15% of the total weight of the mixture, the spray pressure is 0.2 - 0.4MPa, the ultrasonic vibration device is turned on synchronously, the frequency is 20 - 40kHz, and combined with a specific shear rate and granulation time, wet granules with a particle size of 0.8 - 1.5mm are obtained, ensuring the uniformity and forming quality of the granules. The fluidized bed drying adopts a segmented temperature control mode. The inlet air temperature in the initial stage is 28 - 30°C, and it is increased to 32 - 35°C in the later stage. The total drying time is 20 - 30 minutes, and the water content is precisely controlled to be ≤2.5%, ensuring the drying effect of the product while avoiding over-drying from affecting the active ingredients. When tableting, the surface of the punch of the high-speed rotary tablet press is coated with a nano-ceramic coating with a thickness of 0.1 - 0.3μm, the surface roughness Ra of the punch of the tablet press is ≤0.05μm, the tableting pressure is set to 8 - 12kN, the die diameter is 10 - 15mm, and the die gap is 0.03 - 0.08mm, making the tablet core regular in shape, suitable in hardness, and not easy to break, ensuring the stability and quality of the product in each link and providing a reliable hairball removal solution for pets.

[0027] In the packaging process, aluminum-plastic blister packaging is used and filled with nitrogen, the nitrogen replacement rate is 95% - 98%, the sealing temperature is 120 - 150°C, and the sealing pressure is 0.3 - 0.5MPa. Aluminum-plastic blister packaging can effectively isolate oxygen and moisture, prevent the product from oxidation and deterioration, deliquescence, just like putting a solid "protective suit" on the hairball removal tablets, greatly extending the shelf life and ensuring that pet owners can buy products with consistent quality. Even under long-term storage or complex transportation conditions, the product can still maintain good performance and be ready to serve the pet's health at any time.

[0028] The coated tablets are placed in a light-proof and thermostatic incubator at a temperature of 18 - 22°C and a humidity of 25% - 35% for 36 - 48 hours of curing. The incubator is equipped with a temperature and humidity feedback control system with a temperature fluctuation of ≤±0.5°C and a humidity fluctuation of ≤±3%. This delicate thermostatic curing treatment makes the coating more firm and uniform, further enhancing the moisture-proof and anti-oxidation capabilities of the product, stabilizing the internal structure of the product at the same time, laying a solid foundation for the stability of the product during storage and subsequent use, and reducing the risk of quality deterioration caused by environmental factors. Detailed implementation mode

[0029] To facilitate the understanding of the present invention, the present invention will be described more comprehensively below. Preferred embodiments of the present invention are given below. However, the present invention can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the understanding of the disclosure of the present invention more thorough and comprehensive.

[0030] Example 1: A method for preparing an emotion-relieving capsule based on a composite formula, comprising the following steps: Step 1. Raw material pretreatment: 50 g of lavender extract and 30 g of valerian extract are respectively placed in a low-temperature drying oven and dried at 40°C for 5 hours to remove excess moisture. After drying, use an ultrafine pulverizer to pulverize them, control the pulverizing temperature below 20°C, the pulverizing time is 10 minutes, and pass through a 200-mesh sieve after pulverizing to obtain fine powder for standby.

[0031] Step 2. Active ingredient mixing: Weigh 30 parts of the above-mentioned lavender extract fine powder, 20 parts of valerian extract fine powder, 10 parts of γ-aminobutyric acid (GABA), and 8 parts of wild jujube seed oil microcapsules by weight, put them into a three-dimensional mixer, and mix at a speed of 30 r / min for 20 minutes to make the components evenly mixed.

[0032] Step 3. Auxiliary material addition: Add 25 parts of microcrystalline cellulose and 15 parts of lactose to the mixer in sequence, and continue to stir at 30 r / min for 15 minutes. Then add 2 parts of magnesium stearate and 3 parts of silicon dioxide, and mix for another 5 minutes to ensure that the auxiliary materials and the active ingredients are fully and evenly mixed.

[0033] Step 4. Granulation: Use an ethanol solution containing 2% hydroxypropyl methylcellulose (HPMC) as a wetting agent, and slowly add the wetting agent to the mixed material through a peristaltic pump. The dosage of the wetting agent is 12% of the total weight of the mixed material. During the addition process, turn on the stirring paddle, and the stirring speed is 180 r / min to make the material fully wetted to form a soft material. Transfer the soft material to a swing granulator and granulate at a speed of 150 r / min to obtain wet granules with a particle size of 1 - 2 mm.

[0034] Step Five, Drying: Place the wet granules in a fluidized bed dryer, set the inlet air temperature at 50°C and the air velocity at 1.2 m³ / s, and dry until the water content of the granules ≤ 5%. During the drying process, turn the granules every 10 minutes to ensure uniform drying.

[0035] Step Six, Granule Screening: Screen the dried granules through a 16-mesh sieve to remove the adhered large granules and fine powder, so that the granule sizes are uniform.

[0036] Step Seven, Capsule Filling: Fill the screened granules into No. 0 empty capsules using a capsule filling machine, control the filling amount of each capsule to be 500 mg, and obtain the mood-soothing capsules.

[0037] Example 2: A method for preparing mood-soothing capsules based on a composite formula, comprising the following steps: Step One, Raw Material Pretreatment: Place 40 g of chamomile extract and 35 g of oat extract in a vacuum drying oven, and dry at 50°C and a vacuum degree of -0.08 MPa for 4 hours. After drying, use an air-flow pulverizer for pulverization, control the pulverization temperature at about 15°C, the pulverization time at 8 minutes, and screen through a 250-mesh sieve after pulverization to collect the fine powder.

[0038] Step Two, Active Ingredient Mixing: Weigh 25 parts by weight of chamomile extract fine powder, 22 parts by weight of oat extract fine powder, 12 parts of L-theanine, and 6 parts of phosphatidylserine microcapsules, put them into a planetary mixer, and mix at a rotation speed of 35 r / min for 25 minutes to achieve uniform mixing.

[0039] Step Three, Excipient Addition: Add 30 parts of pregelatinized starch and 12 parts of mannitol to the mixer in sequence, and continue stirring for 18 minutes. Then add 1.5 parts of calcium stearate and 2.5 parts of talcum powder, and mix for 8 minutes to ensure uniform dispersion of the excipients.

[0040] Step Four, Granulation: Use an ethanol solution containing 3% hydroxypropyl methylcellulose (HPMC) as a wetting agent, and evenly spray the wetting agent on the mixture using a spraying device. The dosage of the wetting agent is 13% of the total weight of the mixture. At the same time, start a high-speed shearing granulator, with a shearing speed of 200 r / min, and granulate for 10 minutes to obtain wet granules with a particle size of 1.2 - 2.2 mm.

[0041] Step Five, Drying: Place the wet granules in a hot air circulation oven, set the temperature at 55°C, turn them over every 15 minutes, and dry until the water content ≤ 4.5%.

[0042] Step 6, Granulation: Use an 18-mesh sieve to granulate the dried granules so that the granules meet the filling requirements.

[0043] Step 7, Capsule Filling: Fill the granulated granules into No. 0 empty capsules through a capsule filling device, with a filling amount of 520 mg per capsule to complete the preparation of the mood-soothing capsules.

[0044] Example 3: A method for preparing mood-soothing capsules based on a composite formula, comprising the following steps: Step 1, Raw Material Pretreatment: Take 45 g of Melissa officinalis extract and 28 g of Piper methysticum extract, and perform drying treatment in a freeze dryer. The drying temperature is -50°C, the vacuum degree is -0.09 MPa, and the drying time is 12 hours. After drying, use a freeze grinder to crush, and keep the temperature below -10°C during the crushing process. The crushing time is 12 minutes, and pass through a 300-mesh sieve to obtain fine raw material powder.

[0045] Step 2, Active Ingredient Mixing: Weigh 28 parts of Melissa officinalis extract fine powder, 18 parts of Piper methysticum extract fine powder, 8 parts of 5-hydroxytryptophan, and 7 parts of fish oil microcapsules by weight, add them to a double-cone mixer, and mix at a speed of 40 r / min for 30 minutes.

[0046] Step 3, Excipient Addition: Add 28 parts of sodium carboxymethylcellulose and 13 parts of xylitol to the mixer in sequence, and stir for 20 minutes. Then add 3 parts of stearic acid and 3 parts of microcrystalline silica, and mix for another 10 minutes to fully blend the excipients with the active ingredients.

[0047] Step 4, Granulation: Use an ethanol solution containing 2.5% hydroxypropyl methylcellulose (HPMC) as a wetting agent, and add it to the mixture through a metering pump. The dosage of the wetting agent is 14% of the total weight of the mixture. Granulate for 12 minutes under the condition that the stirring paddle speed is 220 r / min to form wet granules with a particle size of 1.5 - 2.5 mm.

[0048] Step 5, Drying: Place the wet granules in a fluidized bed dryer, set the inlet air temperature to 60°C, the wind speed to 1.5 m³ / s, and dry until the water content ≤ 4%.

[0049] Step 6, Granulation: Use a 20-mesh sieve to granulate the dried granules to ensure the uniformity of the granules.

[0050] Step 7, Capsule Filling: Use a capsule filling production line to fill the granulated granules into No. 0 empty capsules, with a filling amount of 550 mg per capsule to make mood-soothing capsules.

[0051] Example 4: A method for preparing an emotion-relieving capsule based on a composite formula. In the step of mixing active ingredients, 22 parts by weight of lavender extract fine powder, 18 parts by weight of valerian extract fine powder, 12 parts by weight of γ-aminobutyric acid (GABA), and 10 parts by weight of sour jujube seed oil microcapsules are weighed. The remaining steps are the same as those in Example 1. Finally, emotion-relieving capsules with a filling amount of 530 mg per capsule are prepared.

[0052] Example 5: A method for preparing an emotion-relieving capsule based on a composite formula, comprising the following steps: Step 1, raw material pretreatment: 55 g of rose extract and 32 g of passionflower extract are dried in a forced-air drying oven at 45 °C for 6 hours. After drying, they are pulverized using a colloid mill, with the pulverizing temperature controlled below 25 °C, the pulverizing time being 15 minutes, and passing through a 350-mesh sieve to obtain raw material fine powder.

[0053] Step 2, active ingredient mixing: 35 parts by weight of rose extract fine powder, 25 parts by weight of passionflower extract fine powder, 15 parts by weight of theanine, and 9 parts by weight of phosphatidylserine microcapsules are weighed and placed in a high-speed mixer, and mixed at a rotation speed of 50 r / min for 35 minutes.

[0054] Step 3, auxiliary material addition: 32 parts by weight of microcrystalline cellulose and 18 parts by weight of lactose are sequentially added to the mixer and stirred for 22 minutes. Then 2.5 parts by weight of magnesium stearate and 3.5 parts by weight of silicon dioxide are added and mixed for 12 minutes.

[0055] Step 4, granulation: An ethanol solution containing 3.5% hydroxypropyl methylcellulose (HPMC) is used as a wetting agent and sprayed onto the mixed material through a pressure nozzle, with the amount of wetting agent being 15% of the total weight of the mixed material. Granulation is carried out for 15 minutes at a stirring speed of 250 r / min to obtain wet granules with a particle size of 1.8 - 2.8 mm.

[0056] Step 5, drying: The wet granules are placed in a vacuum drying oven and dried at 55 °C and a vacuum degree of -0.08 MPa until the water content ≤ 3.5%.

[0057] Step 6, sizing: The dried granules are sized using a 22-mesh sieve.

[0058] Step 7, capsule filling: The sized granules are filled into No. 0 empty capsules using a capsule filling machine, with the filling amount per capsule being 580 mg, to obtain emotion-relieving capsules.

[0059] Comparative Example 1: A preparation method of an emotion-relieving capsule based on a composite formula, comprising the following steps: Step 1, raw material pretreatment: Place 50 g of lavender extract and 30 g of valerian extract in a low-temperature drying oven, dry at 40 °C for 5 hours to remove excess moisture. After drying, use an ultrafine pulverizer to pulverize them, control the pulverizing temperature below 20 °C, the pulverizing time is 10 minutes, and pass through a 200-mesh sieve after pulverization to obtain fine powder for standby.

[0060] Step 2, active ingredient mixing: Weigh 30 parts of the above-mentioned lavender extract fine powder and 20 parts of valerian extract fine powder by weight, put them into a three-dimensional mixer, and mix at a speed of 30 r / min for 20 minutes.

[0061] Step 3, excipient addition: Add 25 parts of microcrystalline cellulose and 15 parts of lactose to the mixer in sequence, continue to stir at 30 r / min for 15 minutes. Then add 2 parts of magnesium stearate and 3 parts of silicon dioxide, and mix for another 5 minutes.

[0062] Step 4, granulation: Use an ethanol solution containing 2% hydroxypropyl methylcellulose (HPMC) as a wetting agent, and slowly add the wetting agent to the mixed material through a peristaltic pump. The dosage of the wetting agent is 12% of the total weight of the mixed material. During the addition process, turn on the stirring paddle, and the stirring speed is 180 r / min to fully wet the material to form a soft material. Transfer the soft material to a shaking granulator, granulate at a speed of 150 r / min to obtain wet granules with a particle size of 1 - 2 mm.

[0063] Step 5, drying: Place the wet granules in a fluidized bed dryer, set the inlet air temperature to 50 °C, the wind speed to 1.2 m³ / s, and dry until the water content of the granules ≤ 5%. During the drying process, turn the granules once every 10 minutes to ensure uniform drying.

[0064] Step 6, sizing: Screen the dried granules through a 16-mesh sieve to remove agglomerated large particles and fine powder, so that the particle sizes are uniform.

[0065] Step 7, filling capsules: Fill the sized granules into No. 0 empty capsules using a capsule filling machine, and control the filling amount of each capsule to be 500 mg. This comparative example does not add γ-aminobutyric acid (GABA) and wild jujube seed oil microcapsules to compare their effects on the capsules.

[0066] Comparative Example 2: A preparation method of an emotion-relieving capsule based on a composite formula, comprising the following steps: Step 1. Raw material pretreatment: Place 40 g of chamomile extract and 35 g of oat extract in a vacuum drying oven and dry at 50°C under a vacuum of -0.08 MPa for 4 hours. After drying, use an air jet mill to crush, control the crushing temperature at about 15°C, the crushing time is 8 minutes, and pass through a 250-mesh sieve after crushing to collect the fine powder.

[0067] Step 2. Active ingredient mixing: Weigh 25 parts of chamomile extract fine powder, 22 parts of oat extract fine powder, and 12 parts of L-theanine by weight, put them into a planetary mixer, and mix at a speed of 35 r / min for 25 minutes.

[0068] Step 3. Auxiliary material addition: Add 30 parts of pregelatinized starch and 12 parts of mannitol to the mixer in sequence, and continue to stir for 18 minutes. Then add 1.5 parts of calcium stearate and 2.5 parts of talc powder and mix for 8 minutes.

[0069] Step 4. Granulation: Use an ethanol solution containing 3% hydroxypropyl methylcellulose (HPMC) as a wetting agent, and use a spraying device to evenly spray the wetting agent on the mixed material. The dosage of the wetting agent is 13% of the total weight of the mixed material. At the same time, turn on a high-speed shear granulator, the shear speed is 200 r / min, and granulate for 10 minutes to obtain wet granules with a particle size of 1.2 - 2.2 mm.

[0070] Step 5. Drying: Put the wet granules into a hot air circulation oven, set the temperature at 55°C, turn them over every 15 minutes, and dry until the water content ≤ 4.5%.

[0071] Step 6. Screening: Use an 18-mesh sieve to screen the dried granules to make the granules meet the filling requirements.

[0072] Step 7. Filling capsules: Fill the screened granules into No. 0 empty capsules through a capsule filling device, and the filling amount per capsule is 520 mg. No phosphatidylserine microcapsules are added in this comparative example to compare its influence on the capsule effect.

[0073] Comparative Example 3: A method for preparing an emotion-relieving capsule based on a compound formula, comprising the following steps: Step 1. Raw material pretreatment: Take 45 g of Melissa officinalis extract and 28 g of Piper methysticum extract, and carry out drying treatment in a freeze dryer. The drying temperature is -50°C, the vacuum degree is -0.09 MPa, and the drying time is 12 hours. After drying, crush with a cryogenic mill, keep the temperature below -10°C during the crushing process, the crushing time is 12 minutes, and pass through a 300-mesh sieve to obtain raw material fine powder.

[0074] Step 2. Active ingredient mixing: Weigh 28 parts by weight of the fine powder of Melissa officinalis extract and 18 parts by weight of the fine powder of Piper methysticum extract, add them to a double-cone mixer, and mix at a speed of 40 r / min for 30 minutes.

[0075] Step 3. Excipient addition: Add 28 parts by weight of sodium carboxymethylcellulose and 13 parts by weight of xylitol to the mixer in sequence, and stir for 20 minutes. Then add 3 parts by weight of stearic acid and 3 parts by weight of microcrystalline silicon dioxide, and mix for another 10 minutes.

[0076] Step 4. Granulation: Use an ethanol solution containing 2.5% hydroxypropyl methylcellulose (HPMC) as a wetting agent, add it to the mixed material through a metering pump, and the dosage of the wetting agent is 14% of the total weight of the mixed material. Granulate for 12 minutes under the condition that the stirring paddle speed is 220 r / min to form wet granules with a particle size of 1.5 - 2.5 mm.

[0077] Step 5. Drying: Place the wet granules in a fluidized bed dryer, set the inlet air temperature at 60 °C and the air speed at 1.5 m³ / s, and dry until the water content ≤ 4%.

[0078] Step 6. Screening: Screen the dried granules with a 20-mesh sieve to ensure the uniformity of the granules.

[0079] Step 7. Filling capsules: Use a capsule filling production line to fill the screened granules into No. 0 empty capsules, and the filling amount per capsule is 550 mg. 5-Hydroxytryptophan and fish oil microcapsules were not added in this comparative example, and it was used to compare its influence on the capsule effect.

[0080] The mood-soothing capsules prepared in Examples 1 - 5 and Comparative Examples 1 - 3 were tested, and the test results are as follows: (1) Component content detection: The content of active ingredients in the capsules was determined by high performance liquid chromatography (HPLC), and the results are shown in Table 1.

[0081] Table 1:

[0082] It can be seen from the test results in Table 1 that the contents of each active ingredient in Examples 1 - 5 meet the expected addition amounts. In Comparative Example 1, γ-aminobutyric acid and wild jujube seed oil microcapsules were not added, and the corresponding components were not detected; in Comparative Example 2, phosphatidylserine microcapsules were not added, and its components were not detected; in Comparative Example 3, 5-hydroxytryptophan and fish oil microcapsules were not added, and the corresponding components were not detected.

[0083] (2) In vitro dissolution test: According to the dissolution test method in the Chinese Pharmacopoeia, the paddle method was used. With 900 mL of water as the dissolution medium, the temperature was 37°C ± 0.5°C, and the rotation speed was 50 r / min. Samples were taken at 30 min, 60 min, 90 min, and 120 min respectively to measure the dissolution, and the results are shown in Table 2.

[0084] Table 2:

[0085] As can be seen from Table 2, the dissolution of the capsules of Examples 1 - 5 at each time point is better than that of Comparative Examples 1 - 3. The dissolution of Example 5 is the highest at 120 min, reaching 99 ± 2%. Due to the lack of components or formulation differences, the dissolution of Comparative Examples 1 - 3 is relatively low.

[0086] Although the embodiments of the present invention have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principles and spirit of the present invention. All equivalent changes and improvements made within the scope of the application of the present invention shall still fall within the scope covered by the patent of the present invention.

Claims

1. A preparation process for pet hairball tablets containing natural fibers, characterized in that, The steps include: Step 1: Pretreatment of fiber raw materials: Place the natural fiber raw materials in a low-temperature pulverizer, control the pulverization temperature to ≤15°C, pulverize for 8-12 minutes, and pass through a 80-120 mesh sieve after pulverization to obtain fiber powder with a particle size of ≤200μm; Step 2, active ingredient embedding: weigh 30-50 parts of fiber powder, 5-10 parts of probiotic freeze-dried powder, and 3-8 parts of fish oil microcapsules by weight, mix the probiotic freeze-dried powder and the fish oil microcapsules, and use spray embedding technology with sodium alginate solution as an embedding agent to form active particles with a particle size of 50-150 μm; Step 3, mixing ingredients: add fiber powder and active particles into a mixer, add 20-30 parts of pregelatinized starch, 5-10 parts of calcium carbonate, and 10-15 parts of maltodextrin in sequence, stir at 20-40r / min for 15-25 minutes under nitrogen protection, then add 2-4 parts of micro powder silica gel and 1-2 parts of magnesium stearate, and continue mixing for 5-8 minutes; Step 4, wet granulation: using an ethanol solution containing 1%-3% hydroxypropyl methylcellulose as a wetting agent, spraying evenly through a high-pressure atomizing spray gun, the amount of the wetting agent is 10%-15% of the total weight of the mixture, and the spray pressure is 0.2-0.4MPa; after wetting, transfer to a wet granulator, granulate at a shear speed of 150-250r / min for 8-12 minutes, and obtain wet granules with a particle size of 0.8-1.5mm; Step 5, fluidized bed drying: Place the wet granules in a fluidized bed, set the air inlet temperature to 30-35°C, the wind speed to 1.0-1.8m³ / s, and dry until the moisture content is ≤2.5%; Step 6, tableting: add the dried granules into a high-speed rotary tablet press, set the tableting pressure to 8-12 kN, the die diameter to 10-15 mm, the punch surface coated with a nano-ceramic coating, the die gap to 0.03-0.08 mm, and press to obtain a tablet core; Step 7, double-layer coating: the inner coating liquid is an ethanol solution containing 5%-10% shellac, and the outer coating liquid is a composite aqueous solution containing 2%-4% polyvinyl alcohol and 1%-2% beeswax. The coating weight gain is 0.5%-1.5% and 2%-4% of the tablet weight, respectively, and the atomized particle size is controlled at 30-60μm; Step 8. Low temperature curing: the coated tablets are placed in a light-proof constant temperature box at a temperature of 18-22°C, a humidity of 25%-35%, and a curing time of 36-48 hours; Step 9: Packaging: Use aluminum-plastic blister packaging machine for packaging, fill with nitrogen protective gas, and seal at a temperature of 120-150°C.

2. The tableting preparation process of a pet hairball tablet containing natural fibers according to claim 1, characterized in that: In the step 1, the natural fiber is at least one of alfalfa fiber, oat fiber or pumpkin fiber, the temperature of the pulverizer cavity is maintained at 10-12° C., and the nitrogen circulation cooling system is continuously operated.

3. The preparation process of a pet hairball tablet containing natural fibers according to claim 1, characterized in that: The spray embedding technical parameters in step 2 are: sodium alginate solution concentration 3%-5%, atomization pressure 0.15-0.25 MPa, and air inlet temperature 40-45°C.

4. The tablet pressing preparation process of a pet hairball tablet containing natural fibers according to claim 1, characterized in that: In the step 3, the purity of nitrogen is ≥99.95%, the internal air pressure of the mixer is maintained at 0.05-0.15 MPa, the speed ratio of the stirring paddle to the cutting blade is 3:1, and the speed of the cutting blade is 80-120 r / min.

5. The preparation process of a pet hairball tablet containing natural fibers according to claim 1, characterized in that: In step 4, the ethanol concentration of the hydroxypropyl methylcellulose ethanol solution is 70%-80%, and the ultrasonic vibration device is turned on synchronously when the wetting agent is sprayed, with a frequency of 20-40 kHz.

6. The tablet pressing preparation process of a pet hairball tablet containing natural fibers according to claim 1, characterized in that: In step 5, the fluidized bed dryer adopts a segmented temperature control mode. The inlet air temperature in the initial stage is 28-30 °C, and it is increased to 32-35 °C in the later stage. The total drying time is 20-30 minutes.

7. A preparation process for pressing tablets of a pet hairball tablet containing natural fibers according to claim 1, characterized in that: In step 6, the thickness of the nano-ceramic coating is 0.1-0.3 μm, and the surface roughness Ra of the punch of the tablet press is ≤0.05 μm.

8. A preparation process for pressing tablets of a pet hairball tablet containing natural fibers according to claim 1, characterized in that: In step 7, 0.1%-0.5% of citric acid is added to the inner coating solution as a plasticizer, and the molecular weight of the polyvinyl alcohol in the outer coating solution is 10,000-30,000 Da.

9. The preparation process of a pet hairball tablet containing natural fibers according to claim 1, characterized in that: In step 8, the incubator is equipped with a temperature and humidity feedback control system, with a temperature fluctuation of ≤±0.5 °C and a humidity fluctuation of ≤±3%.

10. A tablet preparation process for a pet hairball tablet containing natural fibers according to claim 1, characterized in that: In step 9, the nitrogen replacement rate of the aluminum-plastic blister packaging is 95%-98%, and the sealing pressure is 0.3-0.5 MPa.

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