Portable drinking device capable of preparing SOD (superoxide dismutase) nano-particle beverage

Abstract

The invention discloses a portable drinking device capable of preparing an SOD (superoxide dismutase) nano-particle beverage and a method capable of preparing the SOD nano-particle beverage. The device comprises a top cover 1 and a main body 2, an independent storage space 12 is arranged in the top cover 1, and the main body 2 comprises a liquid storage unit 3, an SOD nano-particle preparation unit 4 and a control unit 5. The stored process program is executed through the control unit 5, so that the beverage containing the SOD nano-particles is prepared. The device is simple in structure, convenient to operate and suitable for being used in families or life scenes.

Description

Technical Field

[0001] The present application relates to a portable drinking device for preparing superoxide dismutase (SOD) nanoparticle beverages and a method for preparing SOD nanoparticle-containing beverages, belonging to the technical field of food biochemistry. Background Art

[0002] As a specific antioxidant, superoxide dismutase (SOD) can be reused, efficiently scavenge excess reactive oxygen species in small amounts, and has health care effects such as anti-inflammatory and anti-aging, and has great application potential and market demand in the field of functional foods or beverages. However, firstly, existing SOD beverages in the prior art have the disadvantages that the SOD molecular structure is single and it is difficult to enter the body for antioxidant purposes in the form of nanoparticles. Therefore, preparing SOD nanoparticles to enrich its structure and improve its performance is beneficial to the further development and application of SOD. Secondly, the methods for preparing SOD nanoparticles in the prior art usually require equipment in a laboratory scenario and use a multi-stage heating process at different temperatures, and even the heating temperature is too high, resulting in excessive loss of SOD enzyme activity, which is not suitable for application in daily drinking scenarios at home or in life. Finally, particle size is one of the key parameters for verifying whether nanoparticles are successfully prepared. In the prior art, the preparation and particle size measurement of SOD nanoparticles are carried out separately, and the measurement of particle size also requires cumbersome operation steps such as sampling, filtering membranes, and loading samples, and requires the use of complex and expensive instrument equipment. Therefore, it is of great significance to develop a portable drinking device for preparing SOD nanoparticle beverages that is portable, simple, efficient, energy-saving, has the function of measuring the particle size of nanoparticles, and is applicable to home or life scenarios, as well as a method for preparing SOD nanoparticle beverages. Summary of the Invention

[0003] The purpose of the present application is to provide a portable drinking device for preparing SOD nanoparticle beverages applicable to home or life scenarios and a preparation method thereof. By integrating heating, temperature control, and process program automation functions, it realizes the rapid and convenient preparation of beverages containing SOD nanoparticles in home or life scenarios, and the device can also have the function of measuring the particle size of nanoparticles.

[0004] To achieve the above object, the present application provides the following technical solution: A portable drinking device capable of preparing SOD nanoparticles, including a top cover 1 and a main body 2. The top cover 1 is movably connected above the main body 2. The main body 2 includes a liquid storage unit 3, an SOD nanoparticle preparation unit 4, and a control unit 5. The liquid storage unit 3 is used to hold potable liquid. The SOD nanoparticle preparation unit 4 includes a heating element 6, a temperature detection element 7, and a timing element 8, and is connected to the liquid storage unit 3. The SOD nanoparticle preparation unit 4 is used to detect the temperature and heat the liquid in the liquid storage unit 3. The control unit 5 includes a microprocessor 9 and a data storage unit 10. The control unit 5 is electrically connected to the SOD nanoparticle preparation unit 4. A sealing element 11 is detachably connected to the bottom of the top cover 1. At least one independent storage space 12 is provided inside the top cover 1. At least one storage space 12 is configured with SOD. The sealing element 11 is detachably connected directly below each storage space 12. The data storage unit 10 stores a process program for preparing SOD nanoparticles, including a heating process program: heating the liquid in the liquid storage unit 3 to 60 - 70 °C and keeping it at a constant temperature for 30 - 120 minutes. The control unit 5 can control the SOD nanoparticle preparation unit 4 to heat the liquid in the liquid storage unit 3 to the set temperature and then keep it at a constant temperature for the set time through the process program in the data storage unit 10. The SOD selected is SOD solid powder with a specific activity ≥ 20,000 U / mg that has passed the toxicological safety evaluation, and no pathogenic bacteria can be detected in the SOD. The main body 2 can be externally powered or have a built-in battery, and a power switch is provided on the main body 2. Since the SOD content in papaya is relatively rich, the SOD is preferably SOD extracted from papaya.

[0005] Preferably, the potable liquid is purified water.

[0006] Preferably, the heating process program is: heating the liquid in the liquid storage unit 3 to 65 °C and keeping it at a constant temperature for 55 minutes.

[0007] Preferably, the sealing element is a sliding cover slidably connected to the bottom of the top cover 1.

[0008] Preferably, the top cover 1 and the main body 2 are detachably and sealingly connected.

[0009] Preferably, the liquid storage unit 3 is provided with scale marks that can indicate the liquid volume.

[0010] Preferably, the control unit 5 includes a display screen that can real-time display the temperature of the liquid in the liquid storage unit 3.

[0011] Preferably, the control unit 5 includes a temperature adjustment button and a time adjustment button. Through the temperature adjustment button and the time adjustment button, the target temperature and the constant temperature time for heating the liquid in the liquid storage unit 3 by the SOD nanoparticle preparation unit 4 can be controlled.

[0012] Preferably, the data storage unit 10 stores a calculation program for the particle size of SOD nanoparticles: , where D is the average particle size of the particles to be measured, c is the specific heat capacity of the liquid in the liquid storage unit 3, ρ is the density of the liquid in the liquid storage unit 3, V is the volume of the liquid in the liquid storage unit 3, λ0 is the wavelength of the incident light irradiated by the pulsed laser, I0 is the original incident light intensity of the pulsed laser, expressed in the form of energy density, I m represents the imaginary part of the term in the parentheses, n is the complex refractive index of SOD nanoparticles in the liquid medium in the liquid storage unit 3, which can be measured in advance by methods well-known in the art for measuring complex refractive indices. c, ρ, V, λ0, I0, and n can be set as fixed values and stored in the data storage unit 10. T0 is the temperature of the liquid in the liquid storage unit 3 before being irradiated by the pulsed laser, and T1 is the highest temperature of the liquid in the liquid storage unit 3 after being irradiated by the pulsed laser. T0 and T1 can be measured by the temperature detection element 7. The specific steps for calculating the particle size of SOD nanoparticles are as follows: After the SOD nanoparticle beverage is prepared, after irradiating the liquid in the liquid storage unit 3 with a pulsed laser having an incident light wavelength of λ0 and an intensity of I0, the temperature detection element 7 transmits the measured values of T1 and T0 to the control unit 5. The control unit 5 substitutes the values of T1 and T0 into the SOD nanoparticle particle size calculation program in the data storage unit 10 to obtain the particle size D of the SOD nanoparticles and displays it on the display screen. The essence of this method for measuring particle size is to utilize the principle of energy conversion. When irradiated by a laser, the nanoparticles absorb the laser energy, convert the light energy into heat, and then diffuse to the surrounding environment, causing a temperature rise in the surrounding liquid environment. Under the same conditions, the larger the particle size of the nanoparticles, the more light energy is absorbed, and the greater the temperature rise in the surrounding liquid environment.

[0013] A method for preparing a SOD nanoparticle beverage, using a portable drinking device capable of preparing a SOD nanoparticle beverage and storing a SOD nanoparticle particle size calculation program, opening a top cover 1, injecting pure water into a liquid storage unit 3, removing a sealing element 11 detachably connected to the bottom of the top cover 1, allowing the SOD in the internal storage space 12 of the top cover 1 to fall into the water in the liquid storage unit 3, closing the top cover 1 tightly, sealing a main body 2 and the top cover 1, starting a power switch, and automatically controlling a SOD nanoparticle preparation unit 4 to execute a heating process program in a data storage unit 10, heating the liquid in the liquid storage unit 3 at a heating temperature and time set in the program, and after heating is completed, the program automatically terminates, the heating stops, and a beverage containing SOD nanoparticles is prepared, opening the top cover 1, and irradiating the liquid in the liquid storage unit 3 with a pulsed laser having an incident light wavelength of λ0 and an intensity of I0, and then a temperature detection element 7 transmits the measured T1 and T0 values to the control unit 5, and the control unit 5 substitutes the T1 and T0 values into the SOD nanoparticle particle size calculation program in the data storage unit 10. The average particle size D of the SOD nanoparticles is obtained. The SOD solid powder having a specific activity of ≥20,000 U / mg and having passed the toxicological safety evaluation is selected, and no pathogenic bacteria may be detected in the SOD.

[0014] Compared with the prior art, the beneficial effects of the present application are: 1. It realizes the convenient preparation of SOD nanoparticle beverages, the device structure is simple, the operation is convenient, and it is suitable for use in home or life scenarios; 2. It simplifies the multi-process procedures for the preparation of SOD nanoparticle beverages, and controls the preparation temperature of SOD nanoparticles within 70°C. While being able to prepare SOD nanoparticle beverages, it retains the SOD enzyme activity to the greatest extent, and at the same time, combined with the application scenarios of the beverage, avoids the risk of scalding caused by excessive temperature as much as possible; 3. According to the actual application scenarios of the beverage device that can prepare SOD nanoparticle beverages and the existing detection conditions, the present application establishes a method for preparing nanoparticles under pulsed laser irradiation. The relationship between the particle size of the nanoparticles and the temperature change in the liquid medium surrounding the nanoparticles is established. Without adding any additional detection elements, the temperature change data obtained by the detection is substituted into the SOD nanoparticle size calculation program by the original temperature detection element to achieve a fast and simple measurement of the SOD nanoparticle size. The particle size of the nanoparticles can be detected in time to verify whether the nanoparticles are successfully prepared. This overcomes the disadvantage that the preparation of SOD nanoparticles and the particle size measurement need to be carried out separately in the prior art, omits the cumbersome sampling, membrane filtering, sample loading and other operation steps, avoids over-reliance on complex and expensive instruments and equipment, and makes the preparation of SOD nanoparticles and particle size detection portable, simplified, integrated and automated. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1Schematic structural diagram of the drinking device of this embodiment.

[0016] Figure 2 Particle size diagram of SOD nanoparticles prepared by the drinking device of this embodiment.

[0017] Figure 3 Graph showing the change of SOD enzyme activity recovery rate in the SOD nanoparticle beverage prepared by the drinking device of this embodiment with the preparation temperature.

[0018] In the figure: 1. Top cover; 2. Main body; 3. Liquid storage unit; 4. SOD nanoparticle preparation unit; 5. Control unit; 6. Heating element; 7. Temperature detection element; 8. Timing element; 9. Microprocessor; 10. Data storage unit; 11. Sealing element; 12. Storage space. Detailed implementation manners

[0019] Next, the technical solutions in the embodiments of the present application will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present application.

[0020] Example 1: Please refer to Figure 1, A portable drinking device for preparing SOD nanoparticle beverages, comprising a top cover 1 and a main body 2. The top cover 1 is movably connected above the main body 2. The main body 2 includes a liquid storage unit 3, an SOD nanoparticle preparation unit 4, and a control unit 5. The liquid storage unit 3 is used to hold potable liquid. The SOD nanoparticle preparation unit 4 includes a heating element 6, a temperature detection element 7, and a timing element 8. The SOD nanoparticle preparation unit 4 is connected to the liquid storage unit 3 and is used to detect the temperature and heat the liquid in the liquid storage unit 3. The control unit 5 includes a microprocessor 9 and a data storage unit 10. The control unit 5 is electrically connected to the SOD nanoparticle preparation unit 4. A sealing element 11 is detachably connected to the bottom of the top cover 1. At least one independent storage space 12 is provided inside the top cover 1, and SOD is configured in at least one storage space 12. The sealing element 11 is detachably connected directly below each storage space 12. The data storage unit 10 stores a process program for preparing SOD nanoparticles. The process program includes a heating process program: after heating the liquid in the liquid storage unit 3 to 65 °C, keep it at a constant temperature for 55 minutes. The control unit 5 can control the SOD nanoparticle preparation unit 4 to heat the liquid in the liquid storage unit 3 to a set temperature and then keep it at a constant temperature for a set time through the process program in the data storage unit 10. The liquid storage unit 3 includes a stainless steel inner liner with a capacity of 1 liter; the heating element 6 of the SOD nanoparticle preparation unit 4 is an electric hot plate, the temperature detection element 7 is a thermocouple, and the timing element 8 is an electronic timer; the microprocessor 9 of the control unit 5 uses an ARM Cortex-M3 chip, and the data storage unit 10 is a Flash memory.

[0021] A method for preparing SOD nanoparticle beverages, using the portable drinking device for preparing SOD nanoparticle beverages. Open the top cover 1, inject 200 mL of pure water into the liquid storage unit 3 of the portable drinking device for preparing SOD nanoparticles. Remove the detachable sealing element 11 so that 120 mg of SOD in the internal storage space 12 of the top cover 1 falls into the water in the liquid storage unit 3 of the main body 2. Tighten the top cover 1 to seal the main body 2 and the top cover 1. Turn on the power switch, and the control unit 5 automatically controls the SOD nanoparticle preparation unit 4 to execute the heating process program in the data storage unit 10, heating the liquid in the liquid storage unit 3 at the heating temperature of 65 °C and the constant temperature time of 55 minutes set in the program. After the heating is completed, the program automatically terminates and the heating stops, obtaining a beverage containing SOD nanoparticles. Open the top cover 1 and wait for the liquid to cool below 50 °C before drinking. The SOD selected is SOD solid powder with a specific activity ≥ 20,000 U / mg that has passed the toxicological safety evaluation, and no pathogenic bacteria are detected in the SOD. The particle size distribution diagram of the SOD nanoparticles measured by a Malvern laser particle size analyzer is as Figure 2As shown, SOD nanoparticles with good quality and an average particle size of about 130 nm were prepared. The change in the recovery rate of SOD enzyme activity in the SOD nanoparticle beverage with the preparation temperature is as Figure 3 shown. The recovery rate of SOD enzyme activity is about 85% at a preparation temperature of 65 °C, about 68% at a preparation temperature of 75 °C, and about 20% at a preparation temperature of 85 °C. Compared with the preparation at high temperature, 65 °C can significantly improve the recovery rate of SOD enzyme activity. The recovery rate of enzyme activity (%) = SOD enzyme activity after heating / SOD enzyme activity before heating × 100%.

[0022] Example 2: Please refer to Figure 1 , a portable drinking device for preparing SOD nanoparticle beverages, comprising a top cover 1 and a main body 2. The top cover 1 is movably connected above the main body 2. The main body 2 includes a liquid storage unit 3, an SOD nanoparticle preparation unit 4, and a control unit 5. The liquid storage unit 3 is used to hold the potable liquid. The SOD nanoparticle preparation unit 4 includes a heating element 6, a temperature detection element 7, and a timing element 8, and is connected to the liquid storage unit 3. The SOD nanoparticle preparation unit 4 is used to detect the temperature and heat the liquid in the liquid storage unit 3. The control unit 5 includes a microprocessor 9 and a data storage unit 10. The control unit 5 is electrically connected to the SOD nanoparticle preparation unit 4. A sealing element 11 is detachably connected to the bottom of the top cover 1. Two independent storage spaces 12 are provided inside the top cover 1. At least one storage space 12 is configured with SOD. The sealing element 11 is detachably connected directly below each independent storage space 12. The data storage unit 10 stores a process program for preparing SOD nanoparticles, including a heating process program: heating the liquid in the liquid storage unit 3 to 65 °C and then keeping it at a constant temperature for 55 minutes. The control unit 5 can control the SOD nanoparticle preparation unit 4 to heat the liquid in the liquid storage unit 3 to the set temperature and then keep it at a constant temperature for the set time through the process program in the data storage unit 10. The liquid storage unit 3 includes a stainless steel inner liner with a capacity of 1.5 liters; the heating element 6 of the SOD nanoparticle preparation unit 4 is an electric hot plate, the temperature detection element 7 is a thermocouple, and the timing element 8 is an electronic timer; the microprocessor 9 of the control unit 5 uses an ARM Cortex-M3 chip, and the data storage unit 10 is a Flash memory. The control unit 5 includes a display screen, a temperature adjustment button, and a time adjustment button. The display screen can real-time display the temperature of the liquid in the liquid storage unit 3. The particle size result of the SOD nanoparticles calculated by the SOD nanoparticle particle size calculation program in the data storage unit 10 can be displayed on the display screen. The temperature and time of heating the liquid in the liquid storage unit 3 by the SOD nanoparticle preparation unit 4 can be controlled through the temperature adjustment button and the time adjustment button. The data storage unit 10 stores an SOD nanoparticle particle size calculation program: , where D is the average particle size of the particles to be measured, c is the specific heat capacity of the liquid in the liquid storage unit 3, ρ is the density of the liquid in the liquid storage unit 3, V is the volume of the liquid in the liquid storage unit 3, λ0 is the wavelength of the incident light irradiated by the pulsed laser, I0 is the original incident light intensity irradiated by the pulsed laser, expressed in the form of energy density, I m represents the imaginary part of the term in the parentheses, n is the complex refractive index of the SOD nanoparticles in the liquid in the liquid storage unit 3, which can be measured by methods well-known in the art for measuring complex refractive indices. c, ρ, V, λ0, I0, and n can be set as fixed values and stored in the data storage unit 10. T0 is the temperature of the liquid in the liquid storage unit 3 before being irradiated by the pulsed laser, and T1 is the highest temperature of the liquid in the liquid storage unit 3 after being irradiated by the pulsed laser. T0 and T1 can be measured by the temperature detection element 7.

[0023] The specific steps for calculating the particle size of the SOD nanoparticles are as follows: After the SOD nanoparticle beverage is prepared and the heating stops, a beverage containing SOD nanoparticles is obtained. After irradiating the liquid in the liquid storage unit 3 with a pulsed laser having an incident light wavelength of λ0 and an intensity of I0, the temperature detection element 7 transmits the measured values of T1 and T0 to the control unit 5. The control unit 5 substitutes the values of T1 and T0 into the SOD nanoparticle size calculation program in the data storage unit 10 to obtain the particle size D of the SOD nanoparticles.

[0024] A method for preparing an SOD nanoparticle beverage, using the drinking device capable of preparing an SOD nanoparticle beverage. Open the top cover 1, inject 100 mL of pure water into the liquid storage unit 3 of the drinking device capable of preparing SOD nanoparticles. Remove the detachable sealing element 11 to allow 100 mg of SOD in the internal storage space 12 of the top cover 1 to fall into the water in the liquid storage unit 3 of the main body 2. Tighten the top cover 1 to seal the main body 2 and the top cover 1. Turn on the power switch, and the control unit 5 automatically controls the SOD nanoparticle preparation unit 4 to execute the heating process program in the data storage unit 10 to heat the liquid in the liquid storage unit 3 at the target temperature of 65°C and the constant temperature time of 55 minutes set in the program. After the heating is completed, the program automatically terminates and the heating stops, obtaining a beverage containing SOD nanoparticles. Open the top cover 1. After irradiating the liquid in the liquid storage unit 3 with a pulsed laser having an incident light wavelength of λ0 and an intensity of I0, the temperature detection element 7 transmits the measured values of T1 and T0 to the control unit 5. The control unit 5 substitutes the values of T1 and T0 into the SOD nanoparticle size calculation program in the data storage unit 10 Among them, the particle size D of the SOD nanoparticles is obtained and displayed on the display screen. The SOD can be selected from SOD solid powders with a specific activity of ≥20,000 U / mg that have passed toxicological safety evaluations, and no pathogenic bacteria can be detected in the SOD. n has been previously measured to be 1.7 + i1.0 by a method well-known in the art for measuring the complex refractive index, c is 4.18×10 3 J / (kg·°C), ρ is 1×10 3 kg / m³, V is 0.0001 m³, the λ0 of the pulsed laser for irradiation is 1064×10 -9 m, I0 is 5×10 11 J / m². The above-known data are all pre-stored in the SOD nanoparticle size calculation program in the data storage unit 10. After the temperature detection element measures T1 and T0, the value of T1 - T0 is 0.03 °C. Substituting it into the formula of the SOD nanoparticle size calculation program, D≈165 nm is obtained.

Claims

1. A portable drinking device for preparing SOD nanoparticle beverage, comprising a top cover (1) and a main body (2), characterized in that: The top cover (1) is movably connected directly above the main body (2). The main body (2) includes a liquid storage unit (3), an SOD nanoparticle preparation unit (4), and a control unit (5). The liquid storage unit (3) is used to hold potable liquid. The SOD nanoparticle preparation unit (4) includes a heating element (6), a temperature detection element (7), and a timing element (8), and is connected to the liquid storage unit (3). The SOD nanoparticle preparation unit (4) is used to detect the temperature and heat the liquid in the liquid storage unit (3). The control unit (5) includes a microprocessor (9) and a data storage unit (10). The control unit (5) is electrically connected to the SOD nanoparticle preparation unit (4). A sealing element (11) is detachably connected to the bottom of the top cover (1). At least one independent storage space (12) is provided inside the top cover (1). SOD is configured in at least one storage space (12). The sealing element (11) is detachably connected directly below each storage space (12). The data storage unit (10) stores a process program for preparing SOD nanoparticles. The process program includes a heating process program: heating the liquid in the liquid storage unit (3) to 60 - 70 °C and keeping it at a constant temperature for 30 - 120 minutes. After the control unit (5) controls the SOD nanoparticle preparation unit (4) to heat the liquid in the liquid storage unit (3) to the set temperature through the process program in the data storage unit (10), it keeps it at a constant temperature for the set time. The main body (2) can be externally connected to a power supply or internally equipped with a battery, and a power switch is provided on the main body (2).

2. The portable drinking device capable of preparing SOD nanoparticles according to claim 1, characterized in that: The potable liquid is pure water.

3. The portable drinking device capable of preparing SOD nanoparticles according to claim 1, characterized in that: The heating process program is: heating the liquid in the liquid storage unit (3) to 65 °C and keeping it at a constant temperature for 55 minutes.

4. The portable drinking device capable of preparing SOD nanoparticles according to claim 1, characterized in that: The sealing element (11) is a sliding cover slidably connected to the bottom of the top cover (1).

5. The portable drinking device capable of preparing SOD nanoparticles according to claim 1, wherein: The SOD configured in the storage space (12) is SOD extracted from papaya.

6. The portable drinking device capable of preparing SOD nanoparticles according to claim 1, characterized in that: The control unit (5) further includes a display screen, and the display screen can real - time display the temperature of the liquid in the liquid storage unit (3).

7. The portable drinking device capable of preparing SOD nanoparticles according to claim 1, wherein: The control unit (5) further includes a temperature adjustment button and a time adjustment button. Through the temperature adjustment button and the time adjustment button, the control unit can control the target temperature and the constant - temperature time for the SOD nanoparticle preparation unit (4) to heat the liquid in the liquid storage unit (3).

8. The portable drinking device capable of preparing SOD nanoparticles according to claim 1, characterized in that: The data storage unit (10) stores a program for calculating the particle size of SOD nanoparticles: , where D is the average particle size of the particle to be measured, c is the specific heat capacity of the liquid in the liquid storage unit (3), ρ is the density of the liquid in the liquid storage unit (3), V is the volume of the liquid in the liquid storage unit (3), λ0 is the wavelength of the incident light irradiated by the pulsed laser, I0 is the original incident light intensity irradiated by the pulsed laser, expressed in the form of energy density, I m represents the imaginary part of the term in the brackets, n is the complex refractive index of the SOD nanoparticles in the liquid in the liquid storage unit (3), c, ρ, V, λ0, I0, n can be set as fixed values and stored in the data storage unit (10), T0 is the temperature of the liquid in the liquid storage unit (3) before being irradiated by the pulsed laser, T1 is the highest temperature of the liquid in the liquid storage unit (3) after being irradiated by the pulsed laser, and T0, T1 can be measured by the temperature detection element (7).

9. The portable drinking device capable of preparing SOD nanoparticles according to claim 8, characterized in that: The control unit (5) further includes a display screen, and the numerical value of the average particle size of the nanoparticles calculated by the SOD nanoparticle particle size calculation program can be displayed on the display screen.

10. A method for preparing a SOD nanoparticle beverage, using the portable drinking device capable of preparing a SOD nanoparticle beverage as described in claim 9. Open the top cover (1), inject pure water into the liquid storage unit (3), remove the detachable sealing element (11), so that the SOD in the storage space (12) inside the top cover (1) falls into the water in the liquid storage unit (3) of the main body (2), tighten the top cover (1) to seal the main body (2) and the top cover (1), turn on the power switch, and the control unit (5) automatically controls the SOD nanoparticle preparation unit (4) to execute the heating process program in the data storage unit (10), heating the liquid in the liquid storage unit (3) at the target temperature of 65 °C and the constant temperature time of 55 minutes set in the program. After the heating is completed, the program automatically terminates and the heating stops, obtaining a beverage containing SOD nanoparticles. Open the top cover (1), after irradiating the liquid in the liquid storage unit (3) with pulsed laser light having an incident light wavelength of λ0 and an intensity of I0, the temperature detection element (7) transmits the measured T1 and T0 values to the control unit (5), and the control unit (5) substitutes the T1 and T0 values into the SOD nanoparticle particle size calculation program in the data storage unit (10): to obtain the average particle size D of the SOD nanoparticles and display it on the display screen.

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