Natural plant source long-acting anti-mosquito patch and preparation method thereof

Abstract

The invention discloses a natural plant source long-acting anti-mosquito patch and a preparation method thereof. The natural plant source long-acting anti-mosquito patch is prepared from lemongrass, mint, lavender, chamomile, basil, rosemary, wormwood and geranium. Through the synergistic effect of various natural plants, smell emitted by the raw materials and the like is utilized to interfere with a smell perception system of mosquitoes, so that the mosquitoes are difficult to locate a human body, and the aim of repelling mosquitoes is achieved. Volatile components of different plants are complementary, the mosquito repelling spectrum is wider, and the effect is remarkably improved compared with a single plant source mosquito repelling product. Meanwhile, the plant extract is packaged by a microcapsule technology, and effective components are wrapped in the plant extract and are slowly and continuously released, so that the problem that volatile components of natural plants are easy to lose is effectively solved. The raw materials are all natural materials, so that the mosquito-repellent incense is extremely small in irritation to human skin, free of anaphylactic reaction, especially suitable for daily use of children, pregnant women and people with sensitive skin, capable of meeting all-around mosquito-repellent requirements of families and good in market popularization prospect.

Description

Technical Field

[0001] The present invention relates to the technical field of mosquito prevention, and particularly relates to a natural plant-derived long-acting mosquito repellent sticker mainly composed of natural plant extracts and a preparation method thereof. Background Art

[0002] Mosquito bites can not only cause skin itching and swelling, but also spread various diseases such as malaria, dengue fever, and Japanese encephalitis, seriously threatening people's health. Traditional mosquito prevention products such as mosquito coils and insecticides, although having a certain mosquito repellent effect, mostly contain chemically synthesized mosquito repellents such as DEET (N,N-diethyl-meta-toluamide), Icaridin, etc. Long-term or frequent use may have adverse effects on the human body, especially on special groups such as children, pregnant women, and the elderly, such as skin allergies, respiratory irritation, and potential neurotoxicity. With the enhancement of consumers' awareness of health and environmental protection, there is an urgent need in the market for a safe, effective, and natural mosquito prevention product.

[0003] Plant-derived mosquito repellents have gradually attracted attention due to their natural, low-toxic, and environmentally friendly characteristics. Plants such as lemongrass, mint, lavender, chamomile, pogostemon cablin, and tangerine peel have unique volatile odors that can repel mosquitoes and are relatively safe for the human body. Reasonably combining the active ingredients of these plants and making them into mosquito repellent stickers through advanced processes can not only meet the daily mosquito prevention needs but also conform to the trend of green consumption. However, currently, the plant-derived mosquito repellent stickers on the market have problems such as short mosquito repellent duration, easy volatilization and loss of active ingredients, and poor odor, and urgent improvement is needed. Summary of the Invention

[0004] Aiming at the above deficiencies, the purpose of the present invention is to provide a natural plant-derived long-acting mosquito repellent sticker mainly composed of natural plant extracts, with good mosquito repellent effect and safe to use, and a preparation method thereof.

[0005] To achieve the above object, the technical solution provided by the present invention is: A natural plant-derived long-acting mosquito repellent sticker, the raw materials of which include the following components in parts by weight: 10 - 20 parts of lemongrass, 8 - 16 parts of mint, 2 - 6 parts of lavender, 3 - 9 parts of chamomile, 5 - 15 parts of basil, 2 - 6 parts of rosemary, 6 - 14 parts of mugwort, 8 - 18 parts of adhesive powder, and 30 - 50 parts of geranium.

[0006] As a preferred embodiment of the present invention, the microcapsule technology is adopted to encapsulate the raw materials. This effectively solves the problem of easy volatilization and loss of the volatile components of natural plants. The microcapsules are like tiny "storage repositories" (commonly known as "hollow balls" in coating), which encapsulate the active ingredients inside, enabling them to be released slowly and continuously, greatly extending the mosquito repellent duration of the mosquito repellent sticker. After testing, it can continuously repel mosquitoes for 8 - 12 hours under normal temperature and pressure, far exceeding similar products.

[0007] As a preferred embodiment of the present invention, the natural plant-derived long-acting mosquito repellent patch is die-cut or cut into the desired shape and size by a mold, and the weight of each mosquito repellent patch is controlled to be 3 to 8 grams.

[0008] A method for preparing a natural plant-derived long-acting mosquito repellent patch, comprising the following steps: (1) Pretreating the raw materials: Weighing citronella, mint, lavender, chamomile, basil, rosemary, wormwood and geranium according to the weight ratio, washing and drying until the water content is less than 10%; (2) Crushing: Crushing the dried raw materials into particles with a mesh size of 10 to 50 to obtain plant pellets; (3) Mixing: Putting the plant pellets into an extraction tank, adding anhydrous ethanol 5 to 8 times the total weight of the plant pellets as a solvent, and stirring, mixing and soaking; (4) Extraction: Using the heating reflux extraction method to fully dissolve the active ingredients in the plant pellets in the solvent; (5) Collection: Filtering and collecting while it is hot after the extraction is completed to obtain a filtrate; (6) Concentration: Concentrating the filtrate through a vacuum distillation device, controlling the pressure at 0.05 to 0.1 MPa and the temperature at 40 to 60 °C until the filtrate is concentrated to 1 / 5 - 1 / 3 of the original volume to obtain a concentrated solution; (7) Drying: Transferring the concentrated solution to a vacuum drying oven and drying it to a constant weight under the conditions of a temperature of 50 to 70 °C and a vacuum degree of 0.08 to 0.12 MPa to obtain a dry powder of the plant extract; (8) Microcapsule preparation: Weighing an appropriate amount of the dry powder of the plant extract, adding an arabic gum solution accounting for 10 to 15% of its mass based on the mass of the dry powder of the plant extract, and stirring evenly; slowly dropping a gelatin solution accounting for 5 to 8% of its mass based on the mass of the dry powder of the plant extract; at the same time, adjusting the pH value of the system to 4 to 4.5 with a sodium hydroxide solution, and carrying out a constant-temperature stirring reaction in a water bath at 40 to 50 °C for 1 - 2 hours to wrap the dry powder of the plant extract to form microcapsules; (9) Making: Mixing the microcapsules with the adhesive powder, adding an appropriate amount of distilled water to make a slurry for coating to prepare a natural plant-derived long-acting mosquito repellent patch.

[0009] As a preferred embodiment of the present invention, in step (3), soak for 3 to 5 hours.

[0010] As a preferred embodiment of the present invention, in step (4), the extraction temperature is controlled at 60 to 80 °C and the extraction time is 4 to 6 hours.

[0011] As a preferred embodiment of the present invention, in step (9), the viscosity of the slurry is 50 to 55 mPa·s and the solid content is 30 to 40%.

[0012] As a preferred embodiment of the present invention, in step (9), the slurry is added to the environmentally friendly water-based glue, wherein the total mass of the slurry accounts for 15-25%, and after stirring evenly, slit coating is carried out, and the coating thickness is 10-15 μm.

[0013] As a preferred embodiment of the present invention, the coating in step (9) is carried out on a 40-60 gram glassine base paper.

[0014] As a preferred embodiment of the present invention, a thermal printer is used to print the required pattern on the natural plant-derived long-acting mosquito repellent sticker. The printing pressure and temperature of 65-70 degrees will activate the mosquito repellent capsules, emitting a more intense mosquito repellent fragrance and enhancing the effect of repelling mosquitoes.

[0015] The beneficial effects of the present invention are as follows: The natural plant-derived long-acting mosquito repellent sticker provided by the present invention has a reasonable formula. Through the synergistic effect of various natural plants, the odors emitted by raw materials such as lemongrass, mint, and lavender are used to interfere with the olfactory perception system of mosquitoes, making it difficult for them to locate the human body, thereby achieving the purpose of mosquito repellent. The volatile components of different plants complement each other, resulting in a wider mosquito repellent spectrum and significantly improved effects compared to single-plant-source mosquito repellent products. At the same time, the plant extracts are encapsulated by microcapsule technology, with the active ingredients wrapped inside, enabling them to be slowly and continuously released, effectively solving the problem of easy loss of volatile components of natural plants and greatly extending the mosquito repellent time of the mosquito repellent sticker. After testing, it can continuously repel mosquitoes for 8-12 hours under normal temperature and pressure. Moreover, the plant raw materials used in the formula are all natural materials, with extremely low irritation to human skin and no allergic reactions, being particularly suitable for daily use by children, pregnant women, and people with sensitive skin, and can meet the all-round mosquito repellent needs of families. In addition, the preparation process is relatively simple, easy to industrialize, and has good market promotion prospects. Description of the Drawings

[0016] Figure 1 It is a flow chart of the preparation method of the present invention. Detailed Embodiments

[0017] Example 1: Refer to Figure 1 , the embodiment of the present invention provides a natural plant-derived long-acting mosquito repellent sticker and its preparation method. When preparing, it includes the following steps: (1) Pretreat the raw materials: Prepare the following raw materials in parts by weight: 5 parts of lemongrass, 12 parts of mint, 4 parts of lavender, 6 parts of chamomile, 10 parts of basil, 4 parts of rosemary, 9 parts of wormwood, 13 parts of adhesive powder, and 40 parts of geranium. Weigh lemongrass, mint, lavender, chamomile, basil, rosemary, wormwood, and geranium according to the weight ratio, wash them, and dry them to a water content of less than 10%; (2) Crushing: Crush the dried raw materials into particles of 10-50 mesh, preferably 30 mesh, to obtain plant pellets; (3) Mixing: Put the plant pellets into the extraction tank, add absolute ethanol 5 - 8 times the total weight of the plant pellets as the solvent, preferably 6 times the weight of absolute ethanol. Then stir and mix, and soak for 3 - 5 hours, preferably 4 hours. (4) Extraction: Adopt the heating reflux extraction method. Preferably, control the extraction temperature in the extraction tank at 60 - 80 °C, preferably 65 °C, and the extraction time is 4 - 6 hours, preferably 5 hours, so that the active ingredients in the plant pellets are fully dissolved in the solvent. (5) Collection: After the extraction is completed, filter and collect while it is hot. Preferably, the filter residue is extracted again, and the filtrates are combined to obtain the filtrate. (6) Concentration: Concentrate the filtrate through a vacuum distillation device, control the pressure at 0.05 - 0.1 MPa, and the temperature at 40 - 60 °C until the filtrate is concentrated to 1 / 5 - 1 / 3 of the original volume, preferably 1 / 4, to obtain the concentrated solution. (7) Drying: Transfer the concentrated solution to a vacuum drying oven and dry it to a constant weight under the conditions of a temperature of 50 - 70 °C and a vacuum degree of 0.08 - 0.12 MPa to obtain the dry powder of the plant extract. (8) Microcapsule preparation: Weigh an appropriate amount of the dry powder of the plant extract, add an arabic gum solution accounting for 10 - 15% of its mass based on the mass of the dry powder of the plant extract, preferably 12%, and stir evenly; slowly drip a gelatin solution accounting for 5 - 8% of its mass based on the mass of the dry powder of the plant extract, preferably 6%; at the same time, adjust the pH value of the system to 4 - 4.5 with a sodium hydroxide solution, preferably 4.2, and keep stirring and reacting at a constant temperature in a water bath at 40 - 50 °C, preferably 45 °C for 1 - 2 hours, so that the dry powder of the plant extract is encapsulated to form microcapsules. (9) Manufacturing: Mix the microcapsules with the adhesive powder, add an appropriate amount of distilled water and stir to form a slurry. The ratio of distilled water to the former is preferably 6:4, stir until the viscosity is 50 - 55 mPa·s and the solid content is 30 - 40%. Then discharge it through the coating pipeline into the liquid tank of the coater, and then add environmentally friendly water-based glue. The slurry accounts for 15 - 25% of the total mass. Use the stirring equipment to stir evenly at a constant speed for 15 - 25 minutes, and use a slit coating head to control the coating thickness at 10 - 15 μm; synchronously coat and laminate it on a 40 - 60 g glassine base paper. Set the lamination temperature at 35 - 40 °C and the pressure at 0.5 - 0.6 MPa, and complete the coating and lamination at a running speed of 120 - 125 m / min to ensure that the coating and lamination process is flat and without wrinkles, and form a uniform and dense mosquito repellent glue structure on the glassine base paper to obtain the long-acting mosquito repellent sticker of natural plant origin.

[0018] Preferably, before use, it is preferred to use a thermal printer to print the required pattern on the natural plant-derived long-acting mosquito repellent sticker. The printing pressure and temperature of 65-70 degrees will activate the mosquito repellent capsules, emitting a more intense mosquito repellent fragrance and further enhancing the effect of repelling mosquitoes.

[0019] Example 2: The embodiment of the present invention provides a natural plant-derived long-acting mosquito repellent sticker and its preparation method, which is basically the same as Example 1, with the difference being: preparing the following raw materials in parts by weight: 10 parts of Cymbopogon citratus, 8 parts of Mentha haplocalyx, 2 parts of Lavandula angustifolia, 3 parts of Matricaria chamomilla, 5 parts of Ocimum basilicum, 2 parts of Rosmarinus officinalis, 6 parts of Artemisia argyi, 8 parts of sticky powder, and 30 parts of Pelargonium graveolens.

[0020] Example 3: The embodiment of the present invention provides a natural plant-derived long-acting mosquito repellent sticker and its preparation method, which is basically the same as Example 1, with the difference being: preparing the following raw materials in parts by weight: 20 parts of Cymbopogon citratus, 16 parts of Mentha haplocalyx, 6 parts of Lavandula angustifolia, 8 parts of Matricaria chamomilla, 15 parts of Ocimum basilicum, 6 parts of Rosmarinus officinalis, 10 parts of Artemisia argyi, 18 parts of sticky powder, and 50 parts of Pelargonium graveolens.

[0021] Example 4: The embodiment of the present invention provides a natural plant-derived long-acting mosquito repellent sticker and its preparation method, which is basically the same as Example 1, with the difference being: preparing the following raw materials in parts by weight: 14 parts of Cymbopogon citratus, 15 parts of Mentha haplocalyx, 3 parts of Lavandula angustifolia, 9 parts of Matricaria chamomilla, 8 parts of Ocimum basilicum, 3 parts of Rosmarinus officinalis, 14 parts of Artemisia argyi, 10 parts of sticky powder, and 45 parts of Pelargonium graveolens.

[0022] Example 5: The embodiment of the present invention provides a natural plant-derived long-acting mosquito repellent sticker and its preparation method, which is basically the same as Example 1, with the difference being: preparing the following raw materials in parts by weight: 13 parts of Cymbopogon citratus, 10 parts of Mentha haplocalyx, 2 parts of Lavandula angustifolia, 5 parts of Matricaria chamomilla, 9 parts of Ocimum basilicum, 5 parts of Rosmarinus officinalis, 10 parts of Artemisia argyi, 11 parts of sticky powder, and 42 parts of Pelargonium graveolens.

[0023] Comparative Example 1: Select a common plant-derived mosquito repellent sticker on the market (the main component is a single plant extract and does not use microcapsule technology) as Control 1, and conduct a mosquito repellent effect test simultaneously with the natural plant-derived long-acting mosquito repellent sticker prepared in Example 1 of the present invention.

[0024] Test method: In a closed space of 3m×3m×3m, place 50 female Aedes albopictus mosquitoes, stick the test person's arms with Control 1 and the natural plant-derived long-acting mosquito repellent sticker of the present invention respectively, and observe the number of mosquitoes staying around the arms every 1 hour.

[0025] Test results: In the initial 1 hour, the number of mosquitoes around Control 1 and the long-acting mosquito repellent patch of the natural plant source of the present invention was relatively small; starting from the 2nd hour, the number of mosquitoes around Control 1 gradually increased, and obvious bite marks appeared by the 4th hour; while for the long-acting mosquito repellent patch of the natural plant source of the present invention, until the 8th hour, the number of mosquitoes around it still remained at a low level and no biting phenomenon occurred, effectively and fully demonstrating the long-acting mosquito repellent advantage of the long-acting mosquito repellent patch of the natural plant source of the present invention. When used, after being pasted on the human body, the long-acting mosquito repellent patch of the natural plant source will continuously emit mosquito repellent fragrance for 8 - 12 hours at a body temperature of about 36 degrees Celsius.

[0026] Comparative Example 2: Select a common chemically synthesized mosquito repellent spray containing DEET as Control 2, and conduct a comparative test on skin irritation and allergic reactions with the long-acting mosquito repellent patch of the natural plant source prepared in Example 1 of the present invention.

[0027] Test method: Recruit 50 volunteers aged 20 - 50 years old, randomly divide them into two groups with 25 people in each group. One group pasted the long-acting mosquito repellent patch of the natural plant source of the present invention on the inner side of the arm (simulating long-term contact), and the other group sprayed the mosquito repellent spray Control 2. They were exposed 2 times a day for 7 days, and the skin reactions were observed.

[0028] Test results: The skin of the volunteers who pasted the long-acting mosquito repellent patch of the natural plant source of the present invention showed no abnormal reactions such as redness, itching, and rash; while among the volunteers who used the chemically synthesized mosquito repellent spray Control 2, 5 people had mild skin redness and itching phenomena, indicating that the long-acting mosquito repellent patch of the natural plant source of the present invention has higher safety.

[0029] It can be seen from the above Comparative Examples 1 - 2 that the long-acting mosquito repellent patch of the natural plant source of the present invention performs excellently in terms of mosquito repellent effect and safety, achieving the expected invention purpose.

[0030] According to the disclosure and teachings of the above specification, those skilled in the art to which the present invention pertains can also make changes and modifications to the above embodiments. Therefore, the present invention is not limited to the specific embodiments disclosed and described above, and some modifications and changes to the present invention should also fall within the protection scope of the claims of the present invention. In addition, although some specific terms are used in this specification, these terms are only for convenience of description and do not constitute any limitation to the present invention. The use of other mosquito repellent patches and preparation methods that are the same or similar to it are all within the protection scope of the present invention.

Claims

1. A long-acting mosquito repellent sticker derived from natural plants, characterized in that, Its raw materials include the following components in parts by weight: 10-20 parts of lemongrass, 8-16 parts of mint, 2-6 parts of lavender, 3-9 parts of chamomile, 5-15 parts of basil, 2-6 parts of rosemary, 6-14 parts of wormwood, 8-18 parts of adhesive powder, and 30-50 parts of geranium.

2. The long-acting mosquito-repellent sticker from natural plant sources according to claim 1, characterized in that, The raw materials are encapsulated using microcapsule technology.

3. The long-acting mosquito-repellent sticker from natural plant sources according to claim 1, wherein Its weight is 3-8 grams.

4. The preparation method of the natural plant-derived long-acting mosquito repellent sticker according to any one of claims 1-3, characterized in that, It includes the following steps: (1) Pretreat the raw materials: Weigh lemongrass, mint, lavender, chamomile, basil, rosemary, wormwood, and geranium according to the weight ratio in parts by weight. After cleaning, dry them until the water content is less than 10%. (2) Crushing: Crush the dried raw materials into particles with a mesh size of 10-50 to obtain plant pellets. (3) Mixing: Put the plant pellets into an extraction tank, add anhydrous ethanol 5-8 times the total weight of the plant pellets as a solvent, and stir, mix, and soak. (4) Extraction: Use the heating reflux extraction method to fully dissolve the active ingredients in the plant pellets into the solvent. (5) Collection: After the extraction is completed, filter and collect while it is hot to obtain a filtrate. (6) Concentration: Concentrate the filtrate through a vacuum distillation device, control the pressure at 0.05-0.1 MPa, and the temperature at 40-60 °C until the filtrate is concentrated to 1 / 5-1 / 3 of the original volume to obtain a concentrated solution. (7) Drying: Transfer the concentrated solution to a vacuum drying oven and dry it to a constant weight under the conditions of a temperature of 50-70 °C and a vacuum degree of 0.08-0.12 MPa to obtain a dry powder of plant extract. (8) Microcapsule preparation: Weigh an appropriate amount of the dry powder of plant extract, add an arabic gum solution accounting for 10-15% of its mass based on the mass of the dry powder of plant extract, and stir evenly; slowly drip a gelatin solution accounting for 5-8% of its mass based on the mass of the dry powder of plant extract; at the same time, adjust the pH value of the system to 4-4.5 with a sodium hydroxide solution, and keep stirring and reacting in a water bath at 40-50 °C for 1-2 hours to form microcapsules by encapsulating the dry powder of plant extract. (9) Making: Mix the microcapsules with the adhesive powder, add an appropriate amount of distilled water to make a slurry for coating to prepare a natural plant-derived long-acting mosquito repellent sticker.

5. The preparation method according to claim 4, characterized in that, In step (3), soak for 3-5 hours.

6. The preparation method according to claim 4, characterized in that, In step (4), control the extraction temperature at 60-80 °C and the extraction time at 4-6 hours.

7. The preparation method according to claim 5, wherein In step (9), the viscosity of the slurry is 50-55 mPa·s, and the solid content is 30-40%.

8. The preparation method according to claim 5, characterized in that, In step (9), add the slurry to an environmentally friendly water-based glue, where the slurry accounts for 15-25% of the total mass. After stirring evenly, perform slot coating, and the coating thickness is 10-15 μm.

9. The preparation method according to claim 5, characterized in that In step (9), coat on a 40-60 g glassine base paper.

10. The preparation method according to claim 5, characterized in that, Use a thermal printer to print the required pattern on the natural plant-derived long-acting mosquito repellent sticker.

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