Functional composition containing salicornia bigelovii extract as active ingredient

Abstract

The present invention relates to an antioxidant and whitening functional composition containing a salicornia bigelovii extract as an active ingredient. Specifically, the salicornia bigelovii extract of salicornia bigelovii is used as an effective component, other components comprise a Chinese chestnut extract prepared from Chinese chestnut pumpkins which are special products of mountains, and a wild grape extract and an apple extract which are prepared from wild grapes and apples which are special products of tenzhou, the schisandra chinensis extract adopts schisandra chinensis which is a special product of longevity, and the schisandra chinensis is a special product of longevity. The mulberry extract is prepared from mulberry which is a specialty product of Yuan. According to the invention, compared with a single extract, the mixture of the schisandra chinensis extract and the mulberry extract has more excellent effects of resisting oxidation and whitening the skin through verification of the sea horns, the Chinese chestnuts, the pumpkins, the wild grapes and the apples. Therefore, the functional composition of the present invention can be used as a functional cosmetic composition or a functional intrinsic cosmetic composition.

Description

Technical Field

[0001] The present invention relates to a functional composition containing Salicornia extract as an active ingredient, and more particularly, to an antioxidant and whitening functional cosmetic composition or an internal beauty composition containing Salicornia extract as an active ingredient. Background Art

[0002] Skin aging can be roughly divided into aging caused by internal factors and aging caused by external factors. According to different factors, structural and functional changes occur in the skin. Since the skin is always exposed to the external environment, many of the changes that occur in the skin due to aging are affected by external factors such as ultraviolet rays. As aging progresses, the skin becomes dry, its color darkens, it loses elasticity and wrinkles appear. At this time, oxygen free radicals are inevitably generated in the metabolic process that requires oxygen, which is one of the main causes of aging. Since reactive oxygen species exist in a very unstable state, they attack tissues in the body, oxidize and damage cells, leading to aging. Reactive oxygen species oxidize proteins in the body or lipids in cell membranes, deteriorate human functions and damage DNA, leading to mutations or cancers. In addition, they attack collagen and skin fibers that give the skin elasticity, causing skin aging, resulting in skin sagging and wrinkles. The body has a defense enzyme system, such as SOD (superoxide dismutase), which can scavenge excess oxygen free radicals. Before the age of 20, the body's antioxidant enzyme defense system is active, so there is no problem in maintaining good health. However, as age gradually increases, the antioxidant enzymes decline rapidly. As the enzyme function weakens, the human body is more likely to come into contact with free radicals, and the aging process accelerates. Therefore, appropriately scavenging free radicals is a necessary condition for anti-aging.

[0003] At the same time, melanin in the human body has a protective function against cytotoxic substances such as amines, free radicals, and metal ions. However, when produced in excess, it forms pigmentation such as spots and freckles, accelerating skin aging. Melanin is a phenolic polymer widely distributed in nature and is a complex of melanin and protein. Melanin starts from an amino acid called tyrosine in melanocytes to produce dopa, and then is oxidized again to produce dopaquinone. At this stage, the oxidase tyrosinase is required. Then, it undergoes an auto-oxidation reaction to produce dark brown melanin. Therefore, whitening cosmetics can inhibit the production of melanin by inhibiting the enzyme activity of tyrosinase, thereby having a whitening effect.

[0004] The present inventor has completed the development of an antioxidant and skin-whitening functional composition containing Salicornia europaea extract as an active ingredient. Specifically, in the present invention, Salicornia europaea extract from the special product of Gunsan, Salicornia europaea, is used as an active ingredient, and other ingredients include chestnut extract made from the special product of Gunsan, chestnut squash, wild grape extract and apple extract made from wild grapes and apples which are special products of Fuzhou, Schisandra chinensis extract from the special product of Cheongsong, and mulberry extract made from the special product of Buan. It can be used as a functional cosmetic composition or a functional internal beauty composition.

[0005] Prior art documents

[0006] Patent documents

[0007] (Patent Document 0001) 10-1924353 Summary of the invention

[0008] Problems to be solved by the invention

[0009] The object of the present invention is to provide an antioxidant and whitening functional cosmetic composition containing Salicornia europaea extract as an active ingredient.

[0010] The object of the present invention is to provide an antioxidant and whitening functional internal beauty composition containing Salicornia europaea extract as an active ingredient.

[0011] Another object of the present invention is to provide a method for manufacturing the above cosmetic or internal beauty composition.

[0012] Means for solving the problems

[0013] In order to achieve the above object, the present invention includes: Limonium wrightii, chestnut squash, wild grapes, apples, Schisandra chinensis, and provides an antioxidant and whitening functional cosmetic composition containing a mixed extract of mulberries as an active ingredient.

[0014] In order to achieve the above object, the present invention also includes: Limonium wrightii, chestnut squash, wild grapes, apples, Schisandra chinensis, and provides an antioxidant and whitening functional internal beauty composition containing a mixed extract of mulberries as an active ingredient.

[0015] In one embodiment of the present invention, the "composition" may be a mixture of Salicornia europaea, chestnut squash, wild grapes, apples, Schisandra chinensis, and mulberry extract in a weight ratio of 5-7:0.5-1.5:1-3:2-4:2-4:3-5, but is not limited thereto.

[0016] In one embodiment of the present invention, the "composition" has the ability to scavenge DPPH free radicals, and it may have the effect of inhibiting tyrosinase activity and melanin production, but is not limited thereto.

[0017] Advantages of the invention

[0018] The present invention relates to an antioxidant and whitening functional composition containing Salicornia extract as an active ingredient. Specifically, in the present invention, Salicornia extract from Salicornia, a special product of Gunsan, is used as an active ingredient, and other ingredients include chestnut extract made from chestnut pumpkins, a special product of Gunsan, wild grape extract and apple extract made from wild grapes and apples, special products of Fuzhou, Schisandra chinensis extract from Schisandra chinensis, a special product of Cheongsong, and mulberry extract made from mulberries, a special product of Buan. In the present invention, it has been confirmed that the mixture of Schisandra chinensis and mulberry extracts has more excellent antioxidant and skin-whitening effects compared to using individual extracts for Salicornia europaea, chestnut pumpkins, wild grapes, and apples. Therefore, the functional composition of the present invention can be used as a functional cosmetic composition or a functional internal beauty composition. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 is a diagram showing a method for manufacturing the functional composition of the present invention in an embodiment of the present invention. DETAILED DESCRIPTION OF THE INVENTION

[0020] The present invention will be described in detail below through embodiments of the present invention. However, the following embodiments are provided as examples of the present invention, and if it is determined that a detailed description of techniques or configurations well-known to those skilled in the art may unnecessarily obscure the gist of the present invention, this detailed description may be omitted. However, the present invention is not limited thereto. The present invention can be variously modified and applied within the scope of the description of the following patent claims and equivalents interpreted therefrom.

[0021] In addition, the terms used in this specification are terms for appropriately expressing preferred embodiments of the present invention and may vary according to the intention of the user or operator or the custom of the field to which the present invention pertains. Therefore, the definitions of these terms should be based on the content of the entire specification. Throughout the specification, when a part is referred to as "including" a certain component, this means that it may also include other components without excluding other components, unless explicitly stated to the contrary.

[0022] In this specification, "%" indicating the concentration of a specific substance means (w / w)% for solid / solid, (w / v)% for solid / liquid, and (v / v)% for liquid / liquid.

[0023] In terms of its operation, the present invention provides a functional composition containing Salicornia extract as an active ingredient. The composition has Salicornia extract as the main ingredient, and chestnut pumpkin, wild grape, apple, Schisandra chinensis, and mulberry extracts are additional ingredients.

[0024] At this time, the extract of the present invention can be obtained by extracting and separating from domestic natural raw materials using extraction and separation methods known in the art, and the "extract" defined in the present invention is a solvent obtained by extracting and separating Salicornia europaea using a suitable method. The chestnut squash, wild grape, apple, Schisandra chinensis, and it is extracted from mulberry, and includes, for example, a crude extract, a polar solvent-soluble extract, or a non-polar solvent-soluble extract. The above-mentioned borage, chestnut squash, wild grape, apple, Schisandra chinensis, and a suitable solvent for producing the mulberry extract can be any organic solvent permitted in cosmetics or food science, water or an organic solvent can be used, but not limited thereto, for example, purified water, methanol (alcohol with 1 to 4), methanol, ethanol, propanol, isopropanol, butanol, acetone, ether, benzene, chloroform (various solvents such as chloroform, ethyl acetate, dichloromethane, hexane, cyclohexane, etc.) can be used alone or in combination. As the extraction method, any one of the following methods can be selected: hot water extraction, cold needle extraction, reflux cooling extraction, solvent extraction, steam distillation, ultrasonic extraction, elution, compression. In addition, the required extract can be further subjected to a conventional fractionation process or can be purified using a conventional purification method.

[0025] There is no limitation on the manufacturing method of the extract of the present invention, and a known method can be used. For example, the extract used in the present invention can be prepared in powder form from a primary extract extracted by the above hot water extraction or solvent extraction method through additional processes such as vacuum distillation, freeze drying, or spray drying. In addition, the primary extract can be further purified into fractions by various chromatographies such as silica gel column chromatography, thin layer chromatography, and high performance liquid chromatography. Therefore, in the present invention, the concept of the extract includes all extracts, fractions, and purified products obtained at various stages of extraction, fractionation, or purification, as well as their dilutions, concentrates, or dried products.

[0026] In terms of applications, the present invention can provide an antioxidant and skin-whitening functional cosmetic composition containing Salicornia europaea extract as an active ingredient.

[0027] The cosmetic composition of the present invention can be used in various ways due to its antioxidant effect and skin-whitening function. Products to which the composition can be added include, for example, cosmetics such as various creams, skin lotions, essences, facial cleansing foams, facial cleansers, cleansing creams, shampoos, conditioners, facial washes, soaps, care lotions, facial masks, and makeup.

[0028] The cosmetic composition of the present invention may further contain a composition selected from the group consisting of water-soluble vitamins, oil-soluble vitamins, high molecular weight peptides, high molecular weight polysaccharides, sphingolipids, and seaweed extracts.

[0029] All water-soluble vitamins can be used as long as they can be incorporated into cosmetics. However, vitamins B1, B2, B6, pyridoxine, pyridoxine hydrochloride, vitamin B12, pantothenic acid, niacin, nicotinamide, folic acid, vitamin C, vitamin H, etc., as well as their salts (such as thiamine hydrochloride, sodium ascorbate, etc.) or derivatives (such as sodium 2-phosphoascorbate, magnesium 2-phosphoascorbate, etc.) can also be used in the present invention. They are included in the water-soluble vitamins. Water-soluble vitamins can be obtained by conventional methods, such as microbial transformation, purification from microbial cultures, enzymatic methods, or chemical synthesis.

[0030] The oil-soluble vitamins can be any vitamins that can be incorporated into cosmetics. However, preferably, they include vitamin A, carotenoids, vitamin D2, vitamin D3, vitamin E (d1-α-tocopherol, d-α-tocopherol, d-α-tocopherol), etc., and their derivatives (ascorbyl palmitate, ascorbyl stearate, ascorbyl dipalmitate, dl-α-tocopherol acetate, dl-α-tocopherol nicotinate, vitamin E, DL-panthenol, D-panthenol, panthenyl ethyl ether, etc.) are included in the oil-soluble vitamins used in the present invention. Oil-soluble vitamins can be obtained by conventional methods, such as microbial transformation, purification from microbial cultures, enzymatic methods, or chemical synthesis.

[0031] The above polymer peptides can be any polymer peptides that can be incorporated into cosmetics. However, preferably, they include collagen, hydrolyzed collagen, gelatin, elastin, hydrolyzed elastin, and keratin. High-molecular-weight peptides can be obtained by purification through conventional methods, such as purification from microbial cultures, enzymatic methods, or chemical synthesis, or they can generally be purified and used from natural products such as the dermis of pigs or cows or the silk fibers of silkworms.

[0032] The above high-molecular-weight polysaccharides can be any substances that can be incorporated into cosmetics. However, preferably, they include hydroxyethyl cellulose, xanthan gum, sodium hyaluronate, chondroitin sulfate or its salts (such as sodium salts, etc.). For example, chondroitin sulfate or its salts can generally be purified from mammals or fish and used.

[0033] Sphingolipids can be any that can be incorporated into cosmetics. However, preferred examples include ceramides, phytosphingosine, and sphingolipids. Sphingolipids can generally be purified from mammals, fish, shellfish, yeast, or plants by conventional methods, or obtained by chemical synthesis.

[0034] The seaweed extracts can be any seaweed extracts that can be mixed into cosmetics. However, preferably, they include brown seaweed extracts, red seaweed extracts, green seaweed extracts, etc., as well as carrageenan, arginine, and arginine purified from these seaweed extracts. Alginates, etc. are also included in the seaweed extracts used in the present invention. Seaweed extracts can be obtained by purifying seaweeds by conventional methods.

[0035] The cosmetics of the present invention can also be mixed with other components that are usually mixed in cosmetics as needed. Other components that can be added include oils, humectants, emollients, surfactants, organic and inorganic pigments, organic powders, ultraviolet absorbers, preservatives, disinfectants, antioxidants, plant extracts, pH regulators, alcohols, colorants, fragrances, promoters such as blood circulation promoters, cooling agents, antiperspirants, and pure water. As the oil component, ester oils, hydrocarbon oils, silicone oils, fluorine oils, animal oils, vegetable oils, etc. can be cited.

[0036] As the ester oil, glycerin tri(2-ethylhexanoate), cetyl 2-ethylhexanoate, isopropyl myristate, butyl myristate, isopropyl palmitate, ethyl stearate, octyl palmitate, isocetyl isostearate, butyl stearate, ethyl linoleate, isopropyl linoleate, ethyl oleate, etc. can be cited. Isocetyl myristate, isostearyl myristate, isostearyl palmitate, octyldodecyl myristate, isocetyl isostearate, diethyl sebacate, dimethicone, diisopropyl pimarate, isoalkyl neopentanoate, tri(glyceryl caprylate, caprate), trimethylolpropane tri(2-ethylhexanoate), trimethylolpropane triisostearate, eicosapentaenoic acid tetra(2-ethylhexanoate), cetyl caprylate, decyl laurate, hexyl laurate, decyl myristate, cetyl myristate, stearyl stearate, decyl oleate, cetyl ricinoleate, isoglyceryl laurate. Octyldodecyl linoleate, isopropyl isostearate, 2-ethylhexanoate, stearyl, stearyl 2-ethylhexanoate, hexyl isostearate, ethylene glycol dioctanoate, ethylene glycol dioleate, propylene glycol didecanoate, di(decanoic acid, caprylic acid) propylene glycol, propylene glycol dioctanoate, neopentyl glycol didecanoate, neopentyl glycol dioctanoate, glyceryl trioctanoate, glyceryl tricaprylate, glyceryl triisopalmitate, glyceryl triisostearate, octyldodecyl neopentanoate, isooctanoic acid ester. Stearate, polyglyceryl oleate, polyglyceryl isostearate, triisocetyl citrate, triisalkyl citrate, triisooctyl citrate, lauryl lactate, myristyl lactate, cetyl lactate, octyldecyl lactate, triethyl citrate, acetyltriethyl citrate, acetyl tributyl citrate, trioctyl citrate, diisostearyl malate, 2-ethylhexyl hydroxystearate, di(2-ethylhexyl) succinate, diisobutyl adipate, diisopropyl sebacate, dioctyl sebacate, cholesterol stearate, cholesterol isostearate, scroll, cholesterol hydroxystearate, cholesterol oleate, cholestanol oleate, phytosterol isostearate, phytosterol oleate, isocetyl 12-stearoylhydroxystearate, 12-stearoylhydroxystearic acid and other esters, 12-stearoylhydroxystearate, isostearoyl, etc.

[0037] Examples of hydrocarbon oils include squalene, liquid paraffin, α-olefin oligomers, isoparaffins, ceresin wax, paraffin wax, liquid isoparaffins, polybutene, microcrystalline wax, petrolatum, etc.

[0038] Examples of silicone oils include polymethylsiloxane, methylphenylsilicone, methylcyclopolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, dimethylsiloxane and cetyl methoxysiloxane copolymer, dimethylsiloxane and stearyl methoxysiloxane copolymer, alkyl-modified silicone oil, amino-modified silicone oil, etc.

[0039] Examples of fluorine-based oils and fats include perfluoropolyether, etc.

[0040] Examples of animal and vegetable oils include avocado oil, almond oil, olive oil, sesame oil, rice bran oil, bird flower oil, soybean oil, corn oil, rapeseed oil, apricot oil, palm kernel oil, palm oil, castor oil, sunflower seed oil, seed oil, cottonseed oil, palm oil, balsam pear oil, wheat germ oil, rice germ oil, shea butter, moonlight colostrum, macadamia nut oil, meadow oil, egg yolk oil, beef tallow, horse oil, mink oil, orange rapeseed oil, jojoba oil. Examples of animal or vegetable oils include oils, candelilla wax, carnauba wax, liquid lanolin, and hydrogenated castor oil.

[0041] Examples of humectants include water-soluble low-molecular humectants, oil-soluble molecular humectants, water-soluble polymers, oil-soluble polymers, etc.

[0042] Examples of low-molecular-weight humectants include serine, glutamine, sorbitol, mannitol, sodium pyrrolidone carboxylate, glycerin, propylene glycol, 1,3-butanediol, ethylene glycol, polyethylene glycol B (degree of polymerization n = 2 or more), polypropylene glycol (degree of polymerization n = 2 or more), polyglycerol B (degree of polymerization n = 2 or more), lactic acid, lactate, etc.

[0043] Examples of oil-soluble low-molecular humectants include cholesterol, cholesterol esters, etc.

[0044] Examples of water-soluble polymers include carboxyvinyl polymer, polyaspartate ester, tragacanth gum, xanthan gum, methyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, water-soluble chitin, chitosan, dextrin, etc.

[0045] Examples of oil-soluble polymers include copolymers of polyvinylpyrrolidone and eicosene, copolymers of polyvinylpyrrolidone and hexadecene, nitrocellulose, dextrin fatty acid esters, and polymer silicone. Examples of emollients include cholesteryl long-chain acylglutamate, cholesteryl hydroxystearate, 12-hydroxystearic acid, stearic acid, abietic acid, and cholesteryl lanolin fatty acid ester. Examples of surfactants include nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants.

[0046] Nonionic surfactants include self-emulsifying glyceryl monostearate, propylene glycol fatty acid esters, glycerol fatty acid esters, polyglycerol fatty acid esters, sorbitan fatty acid esters, POE (polyoxyethylene) sorbitan fatty acid esters, POE sorbitan fatty acid esters, POE glycerol fatty acid esters, esters, POE alkyl ethers, POE fatty acid esters, POE hydrogenated castor oil, POE castor oil, POE and POP (polyoxyethylene and polyoxypropylene) copolymers, POE and POP alkyl ethers, polyether-modified silicones. Examples include uric acid alkanolamides, alkylamine oxides, and hydrogenated soy lecithin.

[0047] Anionic surfactants include fatty acid soaps, α-acyl sulfonates, alkyl sulfonates, alkyl allyl sulfonates, alkyl naphthalene sulfonates, alkyl sulfates, POE alkyl ether sulfates, alkyl amide sulfates, alkyl phosphates, POE alkyl phosphates, alkyl phosphoamide phosphates, acyl alkyl taurates, N-acyl amino acid salts, POE alkyl ether carboxylates, alkyl sulfosuccinates, sodium alkyl sulfacetates, acylated hydrolyzed collagen peptide salts, perfluoroalkyl phosphates, etc.

[0048] Examples of cationic surfactants include alkyl trimethyl ammonium chloride, stearyl trimethyl ammonium chloride, stearyl trimethyl ammonium bromide, cetearyl trimethyl ammonium chloride, distearyl dimethyl ammonium chloride, stearyl dimethyl ammonium chloride, behenyl trimethyl ammonium bromide, benzalkonium chloride, diethylaminoethyl stearate amide, dimethylaminopropyl stearate amide, quaternary ammonium salts of lanolin derivatives, etc. Amphoteric surfactants include carboxy β-type, amide β-type, sulfo β-type, hydroxy sulfo β-type, amide sulfobetaine-type, phosphobetaine-type, amino carboxylate-type, imidazoline derivative-type, amide-type and other amphoteric surfactants.

[0049] Organic and inorganic pigments include silicic acid, anhydrous silicic acid, magnesium silicate, talc, sericite, mica, kaolin, Bengal earth, clay, bentonite, titanium-coated mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, inorganic pigments such as aluminum, calcium sulfate, barium sulfate, magnesium sulfate, calcium carbonate, magnesium carbonate, iron oxide, ultramarine, chromium oxide, chromium hydroxide, calamine and their composites; polyamides, polyesters, polypropylenes, polystyrenes, polyurethanes, vinyl resins, urea resins, phenolic resins, fluororesins, silicone resins, acrylic resins, melamine resins, epoxy resins, polycarbonate resins, divinylbenzene and styrene copolymers, silk powder and other organic pigments, cellulose, CI pigment yellow, CI pigment orange, and composite pigments of these inorganic pigments and organic pigments.

[0050] Examples of the organic powder include metal soaps such as calcium stearate; alkyl phosphoric acid metal salts such as sodium cetyl phosphate, zinc laurate, and calcium laurate; polyvalent metal salts of acyl amino acids such as calcium N-lauroyl-β-alaninate, zinc N-lauroyl-β-alaninate, and calcium N-lauroyl glycinate; polyvalent metal salts of amide sulfonic acids such as calcium N-lauroyl taurinate and calcium N-palmitoyl taurinate; N-acyl basic amino acids such as N-ε-lauroyl-L-lysine, N-ε-palmitoyl lysine, N-α-glutaryl ornithine, N-α-lauroyl arginine, and N-α-hydrogenated tallow fatty acid acyl arginine; N-acyl polypeptides such as N-lauroyl glycinyl glycine; α-amino fatty acids such as α-amino caprylic acid and α-amino lauric acid; examples include polyethylene, polypropylene, nylon, polymethyl methacrylate, polystyrene, divinylbenzene and styrene copolymers, and tetrafluoroethylene.

[0051] Examples of the above ultraviolet absorbers include p-aminobenzoic acid, ethyl p-aminobenzoate, pentyl p-aminobenzoate, octyl p-aminobenzoate, ethylene glycol salicylate, phenyl salicylate, octyl salicylate, benzyl salicylate, butylphenyl salicylate, homomenthyl salicylate, and cinnamic acid. 2-ethoxyethyl p-methoxycinnamate, octyl p-methoxycinnamate, mono-2-ethylhexyl glycerol di-p-methoxycinnamate, isopropyl p-methoxycinnamate, a mixture of diisopropyl and diisopropyl cinnamate esters, urocanic acid, ethyl urocanic acid, hydroxymethoxy benzophenone, hydroxymethoxy benzophenone sulfonic acid and its salts, dihydroxy methoxy benzophenone, dihydroxy methoxy diphenol disodium sulfonate, dihydroxy benzophenone, tetra-hydroxy benzophenone, 4-tert-butyl-4'-methoxy dibenzoylmethane, 2,4,6-trianilino-p-(carbon-2'-ethylhexyl-1'-oxy)-1,3,5-triazine, 2-(2-hydroxy-5-methylphenyl) benzotriazole, etc.

[0052] Disinfectants include hinokitiol, triclosan, triclocarban, chlorhexidine gluconate, phenoxyethanol, resorcinol, isopropylmethylphenol, azulene, salicylic acid, zinc pyrithione, benzalkonium chloride, Photosensitive No. 301, sodium mononitroguaiacol, undecylenic acid, etc.

[0053] Examples of antioxidants include butylated hydroxyanisole, propyl gallate, and dehydrated sorbic acid.

[0054] Examples include citric acid, sodium citrate, malic acid, sodium malate, fumaric acid, sodium fumarate, succinic acid, sodium succinate, sodium hydroxide, monosodium hydrogen phosphate, etc.

[0055] Examples of the alcohol include higher alcohols such as cetyl alcohol.

[0056] In addition, the ingredients that can be added are not limited to these, and any ingredients can be mixed within the scope that does not damage the purpose and effects of the present invention.

[0057] The cosmetics of the present invention can be in the form of solutions, emulsions, viscous mixtures, etc.

[0058] The ingredients contained in the cosmetic composition of the present invention can include ingredients commonly used as active ingredients in cosmetic compositions, such as conventional auxiliaries and carriers, such as stabilizers, solubilizers, vitamins, pigments, and fragrances.

[0059] The antioxidant and skin-whitening cosmetic composition of the present invention can be prepared in any formulation commonly manufactured in the art, and examples include emulsions, creams, lotions, masks, foundations, lotions, beauty serums, hair care products, etc.

[0060] Specifically, the cosmetic composition of the present invention includes lotion, skin softener, toner, emulsion, astringent, emulsion, moisturizing emulsion, nutritional emulsion, massage cream, nutritional cream, moisturizing cream, hand cream, foundation, serum, nutritional serum. It includes formulations of mask, soap, cleansing foam, cleansing lotion, cleansing cream, hair conditioner, hair growth liquid, hair care essence, shampoo, hair conditioner, hair conditioner, body lotion, and body wash.

[0061] When the preparation of the present invention is a paste, cream or gel, animal fibers, plant fibers, waxes, paraffins, starches, tracant, cellulose derivatives, polyethylene glycols, silicones, bentonites, silica, talc or zinc oxide can be used as carrier components.

[0062] When the preparation of the present invention is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder can be used as carrier components. In particular, when the preparation is a spray, chlorofluorocarbons and propane can be used. May contain propellants such as butane or dimethyl ether. Used as carrier components.

[0063] When the preparation of the present invention is a solution or emulsion, solvents, solubilizers or emulsifiers are used as carrier components, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butylene glycol oil, glyceryl fatty acid esters, polyethylene glycol or sorbitan fatty acid esters.

[0064] When the preparation of the present invention is a suspension, the carrier components include water, liquid diluents such as ethanol or propylene glycol, suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitan esters and polyoxyethylene sorbitan esters, and microcrystalline cellulose, aluminum. Metahydroxide, bentonite, agar or tracant can be used.

[0065] When the preparation of the present invention is a surfactant-containing cleaner, the carrier components include fatty alcohol sulfates, fatty alcohol ether sulfates, sulfosuccinic acid monoesters, hydroxyethyl sulfonates, imidazolinium derivatives, methyl taurine, sarcosinates, and fatty acid amide ether sulfates. Alkyl acylamino betaines, fatty alcohols, fatty acid glycerol esters, fatty acid diethanolamides, vegetable oils, linoline derivatives, or ethoxylated glycerol fatty acid esters can be used.

[0066] In terms of work, the present invention can provide an antioxidant and whitening functional internal beauty composition containing Salicornia europaea extract as an active ingredient.

[0067] In recent years, due to environmental factors such as fine dust and yellow dust, social factors such as daily life stress, and the increase in the elderly population, people's interest in skin care has increased significantly, and the number of people complaining about skin problems has also increased. Entering an aging society, the main causes of these skin problems are skin dryness, oxidation, and skin inflammatory reactions caused by a decrease in skin moisture content. In particular, skin care products are changing from the concept of cosmetics that can be applied to the concept of edible cosmetics, that is, skin care products that can be eaten and applied. Therefore, the development of "internal beauty" products that maintain skin health by being eaten or drunk in the form of food has recently become an important topic.

[0068] Therefore, the market for cosmetics (internal beauty) that can satisfy both physical health and skin health, that is, edible cosmetics, is rapidly emerging. Different from existing nutritional supplements or vitamins, the internal beauty composition concentrates the active ingredients. It not only has a direct effect on the skin, but also is made into a portable stick or jelly form, which can be easily eaten anytime and anywhere, so it is very popular among consumers.

[0069] Therefore, the present invention provides an internal beauty composition according to the needs of this market.

[0070] Hereinafter, the present invention will be described in more detail through examples. However, the above examples and experimental examples are presented as examples of the present invention, and if it is determined that the detailed description of techniques or configurations known to those skilled in the art unnecessarily obscures the gist of the present invention, this detailed description can be done, but the present invention is not limited thereto. The present invention can be variously modified and applied within the scope of the description of the appended claims and the equivalents thus interpreted.

[0071] <Preparation Example> Manufacturing method of functional composition

[0072] Six types of extracts are mixed to prepare the functional composition of the present invention. The raw materials and mixing ratios shown in Table 1 below correspond to the mixing ratios optimized through various experiments.

[0073]

Table 1

[0074]

[0075] The preparation of the above-mentioned extract can also be as follows.

[0076] 1-1. Method for manufacturing a Salicornia europaea extract

[0077] Salicornia is a specialty of Gunsan City, Jeollabuk-do, South Korea, which is washed and dried. 100 grams of dried kelp is chopped, refluxed with purified water 3 times for 5 hours each time, cold-soaked, and then filtered through a 5μm filter. The filtered extract is concentrated under reduced pressure below 50°C and freeze-dried to obtain a powder, thus obtaining the extract.

[0078] 1-2. Method for manufacturing a Cucurbita moschata extract

[0079] The specialty chestnut squash from Gunsan City, Jeollabuk-do, South Korea is washed and dried in the sun. 100 grams of dried chestnut squash is chopped, refluxed with purified water 3 times for 5 hours each time, cold-soaked, and then filtered through a 5μm filter. The filtered extract is concentrated under reduced pressure below 50°C and freeze-dried to obtain a powdery pumpkin extract.

[0080] 1-3. Method for producing a wild grape extract

[0081] The wild grapes, a specialty of Muju, Jeollabuk-do, South Korea, are washed and dried in the sun. 100 grams of dried wild grapes are chopped, refluxed with purified water 3 times for 5 hours each time, cold-soaked, and then filtered through a 5μm filter. The filtered extract is concentrated under reduced pressure below 50°C and freeze-dried to obtain a powdery wild grape extract.

[0082] 1-4. Method for producing an apple extract

[0083] Apples are a specialty of Muju, Jeollabuk-do, South Korea, which are washed and dried. 100 grams of dried apples are chopped, refluxed with purified water 3 times for 5 hours each time, cold-soaked, and then filtered through a 5μm filter. The filtered extract is concentrated under reduced pressure below 50°C and freeze-dried to obtain a powdery apple extract.

[0084] 1-5. Method for manufacturing a Schisandra chinensis extract

[0085] The magnoliavine fruits, a specialty of Jiangsu Province (should it be a wrong expression, maybe it means Jeollabuk-do), South Korea, are washed and dried. 100 grams of dried magnoliavine fruits are chopped, refluxed with purified water 3 times for 5 hours each time, cold-soaked, and then filtered through a 5μm filter. The filtered extract is concentrated under reduced pressure and freeze-dried below 50°C to obtain a powdery magnoliavine fruit extract.

[0086] 1-6. _Method for manufacturing a mulberry extract

[0087] Mulberry is a special product of Buan City, North Jeolla Province, South Korea, which has been washed and dried. 100 grams of dried mulberries are chopped, refluxed with purified water 3 times for 5 hours each time, cold-digested, and then filtered through a 5μm filter. The filtered extract is concentrated under reduced pressure below 50°C and freeze-dried to obtain powdered mulberry extract.

[0088] 1-7. Preparation of other extracts

[0089] As described above, pear extract, potato extract made from pears and potatoes which are special products of Naju, North Jeolla Province, and fern extract made from bracken which is a special product of Jiangsu Province, North Jeolla Province are used.

[0090] <Experimental Example 1> Testing the antioxidant effects of each extract

[0091] For the antioxidant effects of the extracts prepared in the above Preparation Examples, DPPH assay (measurement of the hydrogen-donating effect on DPPH radicals) was performed. At this time, ascorbic acid (AA) was used as the positive control group. DPPH was diluted to a concentration of 0.2 mM in a 99% (v / v) ethanol solution. In addition, 50 μg of each sample was diluted in 1 mL of 99% (v / v) ethanol solution. 500 μl of 0.2 mM DPPH solution was thoroughly mixed with 100 μl of each sample (50 μg / ml) and reacted for 20 minutes, and then the absorbance (OD) was measured at 517 nm using a spectrophotometer (microplate reader). In addition, the DPPH radical scavenging ability was calculated using Equation 1 below, and the results are shown in Table 2 below.

[0092] [Equation 1]

[0093] DPPH inhibition rate (%) = {1 - (absorbance of the sample-added group / absorbance of the non-sample-added group)} × 100

[0094]

Table 2

[0095] Sample DPPH radical scavenging ability (%) Salicornia europaea extract 64±0.2 Cucurbita moschata Duch. extract 23±0.3 Wild grape extract 38±1.2 Apple extract 47±0.8 Schisandra chinensis extract 49±1.0 Mulberry extract 53±1.7 Pear extract 5±0.7 Potato extract - Fern extract - Ascorbic acid (positive control) 91±0.1

[0096] It can be seen from Table 2 that 6 out of 9 extracts were confirmed to have relatively high DPPH radical scavenging ability. In particular, the DPPH radical scavenging ability of the salicornia extract was the highest, at 64 ± 0.2%. However, the DPPH radical scavenging ability of the pear extract was very low. As for the potato extract and fern extract, it was confirmed that they had no antioxidant effect at all.

[0097] <Experimental Example 2> Testing the antioxidant effects of the mixed extracts

[0098] In order to evaluate the antioxidant effect of the mixed extract prepared by mixing each extract according to Table 3 below based on the antioxidant effect confirmed in Experimental Example 1, DPPH assay (measurement of the hydrogen-donating effect on DPPH radicals) was performed. At this time, ascorbic acid (AA) was used as the positive control group. DPPH was diluted to a concentration of 0.2 mM in a 99% (v / v) ethanol solution. In addition, 50 μg of each sample was diluted in 1 mL of 99% (v / v) ethanol solution. 500 μl of 0.2 mM DPPH solution was thoroughly mixed with 100 μl of each sample (50 μg / ml) and reacted for 20 minutes, and then the absorbance (OD) was measured at 517 nm using a spectrophotometer (microplate reader). In addition, the DPPH radical scavenging ability was calculated using Equation 1 above, and the results are shown in Table 4 below.

[0099]

Table 3

[0100]

[0101]

Table 4

[0102] Sample DPPH radical scavenging ability (%) Example 1 69±1.2 Example 2 82±0.6 Comparative Example 1 63±0.2 Comparative Example 2 53±0.8 Ascorbic acid (positive control) 91±0.1

[0103] As can be seen from Table 2, compared with Example 1 (mixing six extracts in the same mixture), the mixture prepared by mixing six extracts in the optimal mixing ratio of 6:1:2:3:3:4 showed a relatively high antioxidant effect. It was confirmed that the extract of Example 2 had a significantly higher antioxidant effect. On the other hand, except for Example 2, in Comparative Example 1, a pear extract showing a slight antioxidant effect was added and mixed in a ratio of 6:1:2:3:3:4:1, and its antioxidant effect was lower than that of Example 2. In Comparative Example 2, all eggplant extracts were mixed in equal proportions, and it was confirmed that the antioxidant effect was very low.

[0104] <Experimental Example 3> Test of Skin Whitening Effect of Functional Composition

[0105] 3-1. Tyrosinase activity inhibition test

[0106] The inhibition of tyrosinase activity by the composition of 1 and 2, and its antioxidant effect were confirmed in Experimental Example 2. Specifically, distilled water was used as the negative control group. Arbutin was used as the positive control group. 50 μl of each sample (100 μg / ml), 120 μl of 0.1 M phosphate buffer (pH 6.8), and 20 μl of 2 KU / mL tyrosinase were added to each well of a 96-well plate and reacted at 37 °C for 5 minutes, and measured using an ELISA reader (SpectraMax M5, Molecular Devices) (before the reaction). Then, 40 μl of L-tyrosine at a concentration of 1.5 mM was reacted at 37 °C for 15 minutes, and the absorbance was measured at 480 nm using an ELISA reader (after the reaction). At this time, the reaction absorbance of the sample was calculated (absorbance after the reaction - absorbance before the reaction). Based on the measured absorbance, the inhibition rate of tyrosinase activity was calculated using Equation 2 below, and the results are shown in Table 5 below.

[0107] [Equation 2]

[0108] Inhibition rate of tyrosinase activity (%) = {1 - (absorbance of sample / absorbance of negative control)} × 100

[0109] Absorbance of sample = (absorbance after the reaction - absorbance before the reaction)

[0110]

Table 5

[0111] Sample Tyrosinase activity inhibition rate (%) Example 1 56.12±0.7 Example 2 79.05±1.2 Arbutin (positive control) 92.15±0.3

[0112] As shown in Table 5 above, compared with the positive control group of arbutin, the composition of Example 2 of the present invention showed a lower inhibition rate of tyrosinase activity. It was confirmed that the inhibition rate of tyrosinase activity was very high compared with Example 1.

[0113] 3-2. Intracellular melanin production inhibition test

[0114] The compositions of Examples 1 and 2, which were confirmed to have antioxidant effects in Experimental Example 2, were tested for their ability to inhibit intracellular melanin production. Specifically, B16F1 melanoma cells were provided by the Korean Cell Line Bank and cultured. B16F1 melanoma cells are a melanin-producing cell line and are generally used for screening whitening substances. The culture medium for culturing cells was sterilized by adding DMEM, 10% FBS, and 1% penicillin / streptomycin. The cell culture was incubated in an incubator at 37°C and 5% CO2. When the 100 mm culture dish was about 90% full, the melanoma cells were cultured and passaged. The whitening effect of the mixed extract of the present invention was measured. To this end, the change in the amount of melanin produced by treating B16F1 melanoma cells was measured. The cells were seeded in a 6-well plate and treated with the extracts of Examples 1 and 2 at a concentration of 200 μg / ml, and cultured for two days to recover the cells. The recovered cells were reacted with 1 N NaOH containing 10% DMSO at 90°C for 1 hour to fully dissolve the melanin, and then the absorbance was measured at a wavelength of 405 nm using an ELISA reader. The experimental results were calculated by Equation 3 below and are shown in Table 6 below.

[0115] [Equation 3]

[0116] Melanin production inhibition rate (%) = {1 - (absorbance of sample / absorbance of control group)} × 100

[0117]

Table 6

[0118] Sample Melanin production inhibition rate (%) Untreated waste (purified water treatment) - Example 1 32.14±1.2 Example 2 65.26±0.5

[0119] Example 2 of the present invention shown in Table 6 was confirmed to have excellent skin whitening effect by confirming an excellent melanin production inhibition rate compared to Example 1.

[0120] As described above, specific embodiments of the present invention have been described in detail. However, those skilled in the art who understand the spirit of the present invention can add, change, delete, etc. other components within the scope of the same spirit. Thus, however, other embodiments included within the scope of the present invention can be easily proposed. Therefore, the above embodiments should be understood as illustrative in all aspects rather than restrictive. The scope of the present invention is indicated by the scope of the patent claims described below rather than the above detailed description, and all changes or modifications derived from the meaning and scope of the claims and their equivalent concepts are included within the scope of the present invention.

Claims

1. An antioxidant and whitening functional cosmetic composition, wherein, The antioxidant and whitening functional cosmetic composition uses a mixed extract of Salicornia europaea, Cucurbita moschata, wild grapes, apples, Schisandra chinensis, and mulberries as an active ingredient.

2. The antioxidant and whitening functional cosmetic composition according to claim 1, wherein in terms of weight ratio, the composition is a mixture of extracts of seaweed, Cucurbita moschata, wild grapes, apples, Schisandra chinensis, and mulberries at a ratio of 5-7: 0.5-1.5: 1-3: 2-4: 2-4: 3-5.

3. The antioxidant and whitening functional cosmetic composition according to claim 1, wherein the composition has the ability to scavenge DPPH free radicals and has the effects of inhibiting tyrosinase activity and melanin production.

4. An antioxidant and whitening functional internal beauty composition, wherein, The antioxidant and whitening functional internal beauty composition uses a mixed extract of Salicornia europaea, Cucurbita moschata, wild grapes, apples, Schisandra chinensis, and mulberries as an active ingredient.

5. The antioxidant and whitening functional internal beauty composition according to claim 4, wherein the composition has the ability to scavenge DPPH free radicals and has the effects of inhibiting tyrosinase activity and melanin production.

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