Medicinal and edible homologous compound preparation as well as preparation method and application thereof

Abstract

The invention relates to the technical field of medicinal and edible preparations, and particularly provides a medicinal and edible compound preparation as well as a preparation method and application thereof. The medicinal and edible compound preparation comprises the following components: polygonatum odoratum, jujube, liquorice, ginger, fermented soybean, mint, perilla leaf, mulberry leaf, semen cassiae, radix angelicae, platycodon grandiflorum, Chinese olive, gardenia, semen raphani, natural menthol, sorbitol and erythritol. According to the medicinal and edible compound preparation disclosed by the invention, the symptom of throat discomfort can be relieved through the synergistic effect of all the components, and a product suitable for relieving the symptom of throat discomfort can be provided.

Description

Technical Field

[0001] The present invention relates to the technical field of medicated and edible preparations, and particularly relates to a medicated and edible compound preparation, a preparation method thereof, and uses thereof. Background Art

[0002] Pharyngitis is mainly manifested as dryness, burning sensation, pain in the pharynx, obvious pain during swallowing, congestion and swelling of the pharynx, etc. It is mainly manifested as a foreign body sensation in the pharynx, which cannot be coughed out or swallowed. It is more common in adults, with a long course of disease, easy recurrence, stubborn symptoms, and difficult to cure. In addition, a weakened overall resistance, such as fatigue, getting cold, excessive smoking and drinking, etc. are often the inducements of this disease. Excessive smoking and drinking, spicy foods, smoke, dust, and harmful gas stimulation are also common causes.

[0003] In recent years, due to the deterioration of air quality, the increase of people's work pressure, and the increase of bad living habits, etc., the incidence rate of pharyngitis has increased significantly, especially in people who work in an environment with excessive harmful gases and those who use their voices too much. The characteristics of a long course of pharyngitis and easy recurrence have seriously affected the physical and mental health of patients. Previous studies have shown that frequently consuming health foods for clearing the throat and moistening the larynx can play a role in relieving symptoms, assisting in improving physical signs, and preventing the occurrence and development of pharyngitis.

[0004] Western medicine often uses oral APC, intramuscular injection of amidopyrine, gargling with compound borax solution. If the condition is severe, antibiotics or hormonal drugs are commonly used for intervention treatment. However, long-term use of such drugs or improper use of drugs will bring very serious side effects.

[0005] Traditional Chinese medicine emphasizes "preventing disease", and prevention is more important than treatment. Through the methods of traditional Chinese medicine health preservation, the balance of yin and yang of the body and the normal operation of qi and blood are adjusted, so that people can obtain a healthy physique. The homology of medicine and food is an important means of "preventing disease" in traditional Chinese medicine. Ancient medical scientists applied the theories of "four natures" and "five flavors" of traditional Chinese medicine to foods, believing that each food also has "four natures" and "five flavors". Many foods are both foods and drugs, and foods can also prevent and treat diseases just like drugs. In ancient primitive societies, people discovered the properties and effects of various foods and drugs during the process of looking for food, and realized that many foods can be used as medicine. Consuming foods with the homology of medicine and food can not only achieve the effect of treating diseases and strengthening the body, but also has no side effects of drugs. Summary of the Invention

[0006] In view of this, the present invention aims to propose a medicated and edible compound preparation to provide a product suitable for relieving throat discomfort.

[0007] To achieve the above object, the technical solution of the present invention is realized as follows:

[0008] A medicine and food homologous compound preparation, the components of the medicine and food homologous compound preparation include polygonatum odoratum, jujube, licorice, ginger, semen sojae preparatum, mint, perilla leaf, mulberry leaf, cassia seed, angelica dahurica, platycodon grandiflorum, Chinese olive, gardenia, radish seed, natural menthol, sorbitol, and erythritol.

[0009] Further, the components of the medicine and food homologous compound preparation by weight percentage include 10% - 25% polygonatum odoratum, 7% - 10% jujube, 5% - 8% licorice, 4% - 7% ginger, 4% - 7% semen sojae preparatum, 3% - 6% mint, 3% - 6% perilla leaf, 2% - 5% mulberry leaf, 2% - 5% cassia seed, 2% - 5% angelica dahurica, 1% - 3% platycodon grandiflorum, 1% - 3% Chinese olive, 1% - 3% gardenia, 0.5% - 2% radish seed, 0.5% - 2% natural menthol, 10% - 15% sorbitol, and the rest is erythritol.

[0010] Further, the components of the medicine and food homologous compound preparation by weight percentage include 15% - 25% polygonatum odoratum, 8% - 10% jujube, 6% - 8% licorice, 5% - 7% ginger, 5% - 7% semen sojae preparatum, 4% - 6% mint, 4% - 6% perilla leaf, 3% - 5% mulberry leaf, 3% - 5% cassia seed, 3% - 5% angelica dahurica, 2% - 3% platycodon grandiflorum, 2% - 3% Chinese olive, 2% - 3% gardenia, 0.5% - 1.5% radish seed, 0.5% - 1.5% natural menthol, 10% - 13% sorbitol, and the rest is erythritol.

[0011] Further, the components of the medicine and food homologous compound preparation by weight percentage include 20% polygonatum odoratum, 9% jujube, 7% licorice, 6% ginger, 6% semen sojae preparatum, 5% mint, 5% perilla leaf, 4% mulberry leaf, 4% cassia seed, 4% angelica dahurica, 2.5% platycodon grandiflorum, 2.5% Chinese olive, 2.5% gardenia, 1.5% radish seed, 1.5% natural menthol, 12% sorbitol, and the rest is erythritol.

[0012] Compared with the prior art, the present invention has the following advantages:

[0013] The main components of the medicine and food homologous compound preparation of the present invention, such as polygonatum odoratum, licorice, ginger, semen sojae preparatum, perilla leaf, mulberry leaf, angelica dahurica, platycodon grandiflorum, Chinese olive, gardenia, and radish seed, all belong to the lung meridian. The synergistic use makes the medicine and food homologous compound preparation of this embodiment have the effects of clearing heat, anti - inflammation, promoting the production of body fluid and relieving sore throat. It can not only directly relieve the symptoms of throat discomfort, but also reduce the internal lesions to avoid the aggravation of throat discomfort symptoms. Therefore, the medicine and food homologous compound preparation of the present invention can be used to relieve throat discomfort.

[0014] At the same time, the added licorice in the present invention can harmonize all the medicines and play a role in moderating the properties of other components. The combination of licorice with other components of the compound preparation can avoid adverse reactions, coordinate the functions of the compound compatibility, and ensure the exertion of the therapeutic effect of the preparation itself.

[0015] In addition, the natural menthol contained in the components of the medicated and edible homologous compound preparation of the present invention can not only relieve throat inflammation but also play an antiseptic role, making the compound preparation of the present invention easier to preserve. Moreover, the compound preparation of the present invention also contains sorbitol and erythritol, so that on the basis of increasing lower calories, the compound preparation of the present invention has a better taste and is convenient to take.

[0016] Therefore, the medicated and edible homologous compound preparation of the present invention can relieve throat discomfort, has a better taste, is easy to preserve, and has no adverse reactions after use.

[0017] At the same time, the present invention also provides a preparation method of the above-mentioned medicated and edible homologous compound preparation, and the preparation method includes:

[0018] Respectively pulverize, screen the polygonatum odoratum, the jujube, the licorice, the ginger, the semen sojae preparatum, the mint, the perilla leaf, the mulberry leaf, the cassia seed, the dahurian angelica root, the platycodon root, the fructus canarii, the gardenia, the semen raphani and the erythritol, and then conduct the first mixing to obtain a mixed powder.

[0019] Conduct the second mixing of the mixed powder with an adhesive to obtain wet granules.

[0020] Dry the wet granules to obtain dry granules, and mix the dry granules with the natural menthol and the sorbitol to obtain the medicated and edible homologous compound preparation.

[0021] Further, the polygonatum odoratum, the jujube, the licorice, the ginger, the semen sojae preparatum, the mint, the perilla leaf, the mulberry leaf, the cassia seed, the dahurian angelica root, the platycodon root, the fructus canarii, the gardenia, the semen raphani are screened through an 80-mesh sieve; and / or,

[0022] The erythritol is screened through a 40-mesh sieve.

[0023] Further, the mixing time of the first mixing is 3 to 5 minutes; and / or,

[0024] The mixing time of the second mixing is 18 to 25 minutes.

[0025] Further, the adhesive includes an ethanol solution with a volume fraction of 75% to 95%.

[0026] Further, the drying temperature of the wet granules is 40 to 55 °C.

[0027] In addition, the present invention also provides a use of the above-mentioned medicated and edible homologous compound preparation, and the medicated and edible homologous compound preparation is used to relieve throat discomfort. Description of the Drawings

[0028] The accompanying drawings forming a part of the present invention are used to provide a further understanding of the present invention. The schematic embodiments and descriptions thereof of the present invention are used to explain the present invention and do not constitute an improper limitation of the present invention. In the drawings:

[0029] Figure 1 It is a flowchart of the preparation method of the medicated and edible homologous compound preparation of the present invention. Specific embodiments

[0030] It should be noted that, without conflict, the embodiments in the present invention and the features in the embodiments can be combined with each other.

[0031] For those conditions not specified in the present invention, they can be carried out according to conventional conditions or the conditions recommended by the manufacturer of the equipment used. For those reagents or instruments without indicating the manufacturer, they can all be conventional products obtained by purchasing through the market. For the technical means or process methods involved, if the specific conditions are not written, they are carried out according to the existing methods in the field.

[0032] This embodiment relates to a medicated and edible homologous compound preparation, aiming to provide a product suitable for relieving throat discomfort.

[0033] In terms of the overall design, the components of the medicated and edible homologous compound preparation in this embodiment include polygonatum odoratum, jujube, licorice, ginger, semen sojae praeparatum, mint, perilla leaf, mulberry leaf, cassia seed, angelica dahurica, platycodon grandiflorum, Chinese olive, gardenia, radish seed, natural menthol, sorbitol, and erythritol.

[0034] Specifically, the polygonatum odoratum in the above components is a medicinal and edible plant, with a sweet and slightly cold taste, and belongs to the lung and stomach meridians. It has the effects of nourishing yin and moistening dryness, promoting the production of body fluid and quenching thirst, and is used for lung and stomach yin injury, dry-heat cough, dry throat and mouth, and internal heat diabetes.

[0035] The jujube in the components has the effects of invigorating the spleen and stomach, replenishing qi and promoting the production of body fluid, regulating nutrient qi and defending qi, and detoxifying drugs. It can be used to treat stomach deficiency with less food intake, spleen weakness with loose stools, deficiency of qi, blood and body fluid, disharmony between nutrient qi and defending qi, palpitation and anxiety, and hysteria in women, and can be used to treat hypertension, upper respiratory diseases, asthma, throat diseases, and infectious intestinal diseases, etc.

[0036] The licorice in the components has a sweet taste and a neutral nature, enters the spleen, stomach, and lung meridians, and has the effects of regulating the middle and relieving spasm, moistening the lungs, detoxifying, and harmonizing various drugs. When used raw, it can be used to treat sore throat.

[0037] The ginger in the components has a pungent taste and a warm nature, belongs to the lung, spleen, and stomach meridians, and has various effects such as dispersing cold and inducing sweating, resolving phlegm and relieving cough, regulating the stomach, and stopping vomiting.

[0038] Semen Sojae Praeparatum in the composition is bitter, sweet, pungent, and cool in nature; it belongs to the lung and stomach meridians, and has the efficacy of dispersing wind-heat, being able to relieve symptoms such as sore throat, frequent cough, unsmooth expectoration, and slight thirst due to wind-heat cold.

[0039] Mentha haplocalyx Briq. in the composition is pungent, cool in nature, enters the lung and liver meridians, and has the efficacy of dispersing wind-heat, clearing the head and eyes, promoting eruption and relieving sore throat, and regulating qi flow in the liver. It can be used to treat exogenous wind-heat, headache, sore throat, food stagnation and qi distension, liver qi stagnation, etc. In this embodiment, the synergistic use of Mentha haplocalyx Briq. and Semen Sojae Praeparatum can enhance the power of dispersing wind-heat, thus effectively relieving the symptom of sore throat.

[0040] Perilla leaf in the composition is pungent, warm, and belongs to the lung and spleen meridians, and has the efficacy of relieving exterior syndrome by diaphoresis, regulating qi flow and harmonizing the stomach, and can be used for cough and nausea.

[0041] Mulberry leaf in the composition is bitter, sweet, and cold in nature; it belongs to the lung and liver meridians, and has the efficacy of dispersing wind-heat and moistening the lung dryness. The synergistic use with Mentha haplocalyx Briq. in this embodiment can relieve the symptoms of itchy throat and cough.

[0042] Cassia seed in the composition is sweet, bitter, salty, and slightly cold in nature; it belongs to the liver, gallbladder, kidney, and large intestine meridians, and has the efficacy of antibacterial and anti-inflammatory, and can be used to relieve sore throat.

[0043] Angelica dahurica (Fisch. ex Hoffm.) Benth. et Hook. f. ex Franch. et Sav. in the composition is pungent, warm in nature, and belongs to the lung, spleen, and stomach meridians, and has the efficacy of expelling wind and dampness, dredging orifices and relieving pain, and detumescence and discharging pus. In this embodiment, when used together with Platycodon grandiflorus, it can be used to treat the discomfort of the throat in chronic pharyngitis.

[0044] Platycodon grandiflorus (Jacq.) A. DC. in the composition is bitter, pungent, and neutral in nature, and belongs to the lung meridian, and has the efficacy of dispersing lung qi, promoting eruption and relieving sore throat, resolving phlegm, and discharging pus. It can be used for excessive phlegm, chest distress, sore throat and hoarseness, and lung abscess with expectoration of pus. In this embodiment, the synergistic use with Angelica dahurica (Fisch. ex Hoffm.) Benth. et Hook. f. ex Franch. et Sav. can be used to treat the discomfort of the throat in chronic pharyngitis.

[0045] Canarium album (Lour.) Raeusch. in the composition has a sweet, sour, and neutral nature, and belongs to the lung and stomach meridians, and has the efficacy of clearing heat and detoxifying, promoting eruption and relieving sore throat, and promoting the production of body fluid. It can be used to treat sore throat, cough with sticky phlegm, and restlessness with thirst.

[0046] Gardenia jasminoides Ellis in the composition is bitter and cold in nature, and belongs to the heart, lung, and triple energizer meridians, and has the efficacy of purging fire and relieving restlessness, clearing heat and promoting diuresis, cooling blood and detoxifying, antibacterial and anti-inflammatory, and can assist in the treatment of pharyngitis and relieve the symptom of sore throat.

[0047] Semen Raphani in the composition is pungent, sweet, and neutral in nature, and belongs to the lung, spleen, and stomach meridians, and has the efficacy of promoting digestion and relieving distension, and descending qi and resolving phlegm, and can be used to relieve the symptom of excessive cough and phlegm.

[0048] Natural menthol in the composition is a terpene organic compound, which can be used to treat headache and inflammation of the nose, pharynx, and larynx, and has bactericidal and antiseptic effects. In this embodiment, it can be directly used without grinding and sieving, and is used to relieve throat inflammation and as an antiseptic component.

[0049] The sorbitol and erythritol in the components are both sweeteners with low energy and good taste. In this embodiment, they are used to improve the taste of the preparation and make it easier to take. In this embodiment, sorbitol does not need to be crushed and sieved and can be used directly.

[0050] Based on the above introduction to each component, the main ingredients of the medicinal and edible compound preparation of this embodiment, polygonatum, licorice, ginger, light black beans, perilla leaves, mulberry leaves, angelica dahurica, platycodon, green fruit, gardenia and radish seeds, all belong to the lung meridian, and jujube can also be used to treat throat diseases. The coordinated use makes the medicinal and edible compound preparation of this embodiment have the effects of clearing heat, anti-inflammatory, and relieving throat and promoting fluid production. It can not only directly relieve the symptoms of throat discomfort, but also reduce the lesions in the body to avoid the aggravation of the symptoms of throat discomfort. Therefore, the medicinal and edible compound preparation of the present invention can be used to relieve throat discomfort.

[0051] At the same time, the licorice added in this embodiment can reconcile the various medicines and play a role in alleviating the medicinal properties of other ingredients. The use of licorice in combination with other ingredients of the compound preparation can avoid adverse reactions, coordinate the compatibility function of the compound preparation, and ensure the therapeutic effect of the preparation itself.

[0052] In addition, the natural menthol contained in the medicine-food composite preparation of this embodiment can not only relieve pharyngitis but also play a role in preservation, making the composite preparation of the present invention easier to preserve. In addition, the composite preparation of this embodiment also contains sorbitol and erythritol, so that the composite preparation of this embodiment has a better taste and is easy to take on the basis of adding lower calories.

[0053] It is worth noting that the medicine-food compound preparation of the present embodiment is preferably composed of components, for example, the components may include, by weight percentage, 10% to 25% polygonatum, 7% to 10% jujube, 5% to 8% licorice, 4% to 7% ginger, 4% to 7% light black beans, 3% to 6% mint, 3% to 6% perilla leaves, 2% to 5% mulberry leaves, 2% to 5% cassia seeds, 2% to 5% angelica, 1% to 3% platycodon, 1% to 3% green fruit, 1% to 3% gardenia, 0.5% to 2% radish seeds, 0.5% to 2% natural menthol, 10% to 15% sorbitol, and the rest is erythritol.

[0054] Furthermore, in terms of the component composition of the medicated and edible homologous compound preparation of this embodiment, preferably, for example, each component may include 15% - 25% polygonatum odoratum, 8% - 10% jujube, 6% - 8% licorice, 5% - 7% ginger, 5% - 7% sojae semen preparatum, 4% - 6% mint, 4% - 6% perilla leaf, 3% - 5% mulberry leaf, 3% - 5% cassia seed, 3% - 5% dahurian angelica root, 2% - 3% platycodon root, 2% - 3% canarium album fruit, 2% - 3% gardenia fruit, 0.5% - 1.5% radish seed, 0.5% - 1.5% natural menthol, 10% - 13% sorbitol, and the rest is erythritol.

[0055] As a preferred implementation form, each component of the compound preparation of this embodiment, for example, may be 20% polygonatum odoratum, 9% jujube, 7% licorice, 6% ginger, 6% sojae semen preparatum, 5% mint, 5% perilla leaf, 4% mulberry leaf, 4% cassia seed, 4% dahurian angelica root, 2.5% platycodon root, 2.5% canarium album fruit, 2.5% gardenia fruit, 1.5% radish seed, 1.5% natural menthol, 12% sorbitol, and the rest is erythritol.

[0056] In this embodiment, based on the above introduction to the composition of the medicated and edible homologous compound preparation, in specific implementation, an exemplary preparation method of the above-mentioned medicated and edible homologous compound preparation, combined with Figure 1 as shown, specifically includes the following steps:

[0057] Step S1: Respectively crush, sieve polygonatum odoratum, jujube, licorice, ginger, sojae semen preparatum, mint, perilla leaf, mulberry leaf, cassia seed, dahurian angelica root, platycodon root, canarium album fruit, gardenia fruit, radish seed and erythritol, and then conduct the first mixing to obtain a mixed powder;

[0058] In the above step S1, sieve polygonatum odoratum, jujube, licorice, ginger, sojae semen preparatum, mint, perilla leaf, mulberry leaf, cassia seed, dahurian angelica root, platycodon root, canarium album fruit, gardenia fruit and radish seed. As a preferred implementation form, for example, polygonatum odoratum, jujube, licorice, ginger, sojae semen preparatum, mint, perilla leaf, mulberry leaf, cassia seed, dahurian angelica root, platycodon root, canarium album fruit, gardenia fruit and radish seed can be sieved through an 80-mesh sieve.

[0059] Meanwhile, in the above step S1, sieve erythritol. As a preferred implementation form, for example, erythritol can be sieved through a 40-mesh sieve. And the rest of the above components do not need to be crushed and sieved and can be directly used.

[0060] In addition, in the above step S1, the mixing time of the first mixing, preferably, for example, can be 3 - 5 minutes.

[0061] Step S2: Conduct the second mixing of the above-mentioned mixed powder and the binder to obtain wet granules.

[0062] The adhesive in the above step S2 is preferably, for example, an ethanol solution with a volume fraction of 75% to 95%.

[0063] Meanwhile, the mixing time for the second mixing in the above step S2 is preferably, for example, 18 to 25 minutes.

[0064] Step S3: Dry the wet granules to obtain dry granules, and mix the dry granules with natural menthol and sorbitol to obtain the medicine and food homology compound preparation.

[0065] In the above step S3, the drying temperature of the wet granules is preferably, for example, 40 to 55 °C.

[0066] According to the above introduction, the preparation method of the medicine and food homology compound preparation in this embodiment adopts the wet granulation process, which has a simple process and is easy to operate, and is conducive to industrial production.

[0067] In addition, this embodiment also relates to the use of the above medicine and food homology compound preparation. Specifically, the medicine and food homology compound preparation in this embodiment is used to relieve the discomfort of dry, itchy and hoarse throat. Therefore, the medicine and food homology compound preparation in this embodiment can provide a product suitable for relieving the discomfort of dry, itchy and hoarse throat.

[0068] Based on the above introduction, for the medicine and food homology compound preparation of the present invention and its preparation method and use, further, in specific implementation, the following preparation examples can be referred to.

[0069] Example 1

[0070] This Example 1 is for preparing the above medicine and food homology compound preparation, and its specific preparation steps are as follows:

[0071] S1: After separately pulverizing polygonatum odoratum, jujube, licorice, ginger, semen sojae praeparatum, mint, perilla leaf, mulberry leaf, cassia seed, angelica dahurica, platycodon grandiflorum, fructus canarii, gardenia jasminoides and radish seed, sieve them through an 80-mesh sieve and reserve. After pulverizing erythritol, sieve it through a 40-mesh sieve and reserve. Then, 20 g of polygonatum odoratum, 9 g of jujube, 7 g of licorice, 6 g of ginger, 6 g of semen sojae praeparatum, 5 g of mint, 5 g of perilla leaf, 4 g of mulberry leaf, 4 g of cassia seed, 4 g of angelica dahurica, 2.5 g of platycodon grandiflorum, 2.5 g of fructus canarii, 2.5 g of gardenia jasminoides, 1.5 g of radish seed and 7.5 g of erythritol are subjected to the first mixing to obtain a mixed powder.

[0072] S2: Add an ethanol solution to the mixed powder obtained in step S1 for wet granulation to obtain wet granules.

[0073] S3: Dry the wet granules obtained in step S2 to volatilize the adhesive ethanol to obtain dry granules, and then perform the second mixing of the dry granules with 1.5 g of natural menthol and 12 g of sorbitol for 20 minutes to obtain the medicine and food homology compound preparation.

[0074] Example 2

[0075] S1. After separately pulverizing Polygonatum odoratum, Chinese date, licorice, ginger, semen sojae praeparatum, mint, perilla leaf, mulberry leaf, cassia seed, angelica dahurica, platycodon root, canarium album, gardenia fruit and radish seed, sieve them through an 80-mesh sieve and reserve. After pulverizing erythritol, sieve it through a 40-mesh sieve and reserve. Then, mix 25 g of Polygonatum odoratum, 8 g of Chinese date, 6 g of licorice, 6 g of ginger, 6 g of semen sojae praeparatum, 4 g of mint, 5 g of perilla leaf, 4 g of mulberry leaf, 4 g of cassia seed, 3 g of angelica dahurica, 2.5 g of platycodon root, 2.5 g of canarium album, 2.5 g of gardenia fruit, 1.5 g of radish seed and 7.5 g of erythritol for the first time to obtain a mixed powder.

[0076] S2. Add an ethanol solution to the mixed powder obtained in step S1 for wet granulation to obtain wet granules.

[0077] S3. Dry the wet granules obtained in step S2 to volatilize the binder ethanol to obtain dry granules. Then, mix the dry granules with 1.5 g of natural menthol and 11 g of sorbitol for the second time and mix for 20 minutes to obtain a medicine and food homologous compound preparation.

[0078] Example 3

[0079] S1. After separately pulverizing Polygonatum odoratum, Chinese date, licorice, ginger, semen sojae praeparatum, mint, perilla leaf, mulberry leaf, cassia seed, angelica dahurica, platycodon root, canarium album, gardenia fruit and radish seed, sieve them through an 80-mesh sieve and reserve. After pulverizing erythritol, sieve it through a 40-mesh sieve and reserve. Then, mix 10 g of Polygonatum odoratum, 10 g of Chinese date, 8 g of licorice, 7 g of ginger, 7 g of semen sojae praeparatum, 6 g of mint, 5 g of perilla leaf, 5 g of mulberry leaf, 5 g of cassia seed, 5 g of angelica dahurica, 2.5 g of platycodon root, 3 g of canarium album, 2.5 g of gardenia fruit, 1.5 g of radish seed and 8.5 g of erythritol for the first time to obtain a mixed powder.

[0080] S2. Add an ethanol solution to the mixed powder obtained in step S1 for wet granulation to obtain wet granules.

[0081] S3. Dry the wet granules obtained in step S2 to volatilize the binder ethanol to obtain dry granules. Then, mix the dry granules with 2 g of natural menthol and 12 g of sorbitol for the second time and mix for 20 minutes to obtain a medicine and food homologous compound preparation.

[0082] Example 4

[0083] S1. After separately pulverizing polygonatum odoratum, jujube, licorice, ginger, semen sojae praeparatum, mentha haplocalyx, folium perillae, folium mori, semen cassiae, angelica dahurica, platycodon grandiflorum, fructus canarii, gardenia jasminoides, and semen raphani, sieve them through an 80-mesh sieve for standby. After pulverizing erythritol, sieve it through a 40-mesh sieve for standby. Then, mix 15 g of polygonatum odoratum, 10 g of jujube, 8 g of licorice, 5 g of ginger, 5 g of semen sojae praeparatum, 6 g of mentha haplocalyx, 5 g of folium perillae, 5 g of folium mori, 5 g of semen cassiae, 5 g of angelica dahurica, 2.5 g of platycodon grandiflorum, 3 g of fructus canarii, 2.5 g of gardenia jasminoides, 1.5 g of semen raphani, and 7.5 g of erythritol for the first time to obtain a mixed powder.

[0084] S2. Add an ethanol solution to the mixed powder prepared in step S1 for wet granulation to obtain wet granules.

[0085] S3. Dry the wet granules prepared in step S2 to volatilize the binder ethanol to obtain dry granules. Then, mix the dry granules with 2 g of natural menthol and 12 g of sorbitol for the second time and mix for 20 minutes to obtain a medicated and food homologous compound preparation.

[0086] Verification Example

[0087] This verification example verifies the alleviating effect of this medicated and food homologous compound preparation on throat discomfort by testing the effect of the medicated and food homologous compound preparation prepared in the above Example 1 on a rat model with throat discomfort.

[0088] For the evaluation method of the effect on the rat model with throat discomfort mentioned above, the specific operation steps are as follows:

[0089] 1. Select animal experiment materials:

[0090] Select 40 healthy SD rats, with half males and half females, clean grade, and a body weight of 165 - 210 g.

[0091] 2. Group the animals:

[0092] Divide the SD rats into four groups: negative control group, model control group, compound preparation group, and positive control group, with 10 rats in each group.

[0093] 3. Model the animals:

[0094] Rats in the negative control group are sprayed on the pharynx with normal saline once in the morning and afternoon every day, 2 sprays each time with a nebulizer, for 7 consecutive days; rats in the other three groups are sprayed on the pharynx with 2.5% ammonia water once in the morning and afternoon every day, 2 sprays each time with a nebulizer, for 7 consecutive days; from the 8th to the 14th day, the above four groups of rats are gavaged once every morning with the corresponding test substances.

[0095] 4. Administer drugs to the animals:

[0096] Negative control group: gavaged with an equal volume of sterile water for 7 days at a gavage dose of 20 ml / kg;

[0097] Model control group: gavaged with an equal volume of sterile water for 7 days at a gavage dose of 20 ml / kg;

[0098] Compound preparation group: gavaged with an equal volume of compound preparation for 7 days at a gavage dose of 29.1 g / kg of crude drug;

[0099] Positive control group: gavaged with an equal volume of aspirin solution for 7 days at a gavage dose of 0.10 g / kg.

[0100] 5. Observation indicators:

[0101] Rat body weight, total white blood cell count, lymphocyte count, interleukin-6, tumor necrosis factor-α

[0102] 6. Experimental results:

[0103] The effects of each test group on rat body weight are shown in Table 1.

[0104] Table 1

[0105] Group Quantity (pcs) Body weight on the 4th day (g) Body weight on the 7th day (g) Negative control group 10 200.1±10.3 227.2±11.8 Model control group 10 <![CDATA[174.5±5.7 a > <![CDATA[175.1±8.6 a > Compound preparation group 10 <![CDATA[185.9±4.1 b > <![CDATA[198.4±10.7 b > Positive control group 10 <![CDATA[184.2±5.9 b > <![CDATA[198.1±7.6 b >

[0106] Note: Compared with the negative control group, a P < 0.01; compared with the model control group, b P < 0.01.

[0107] It can be seen from the data in Table 1 that compared with the negative control group, the body weight of rats in the model control group decreased significantly, with a significant difference (P < 0.01); compared with the model control group, the body weight of rats in the compound preparation group and the positive control group increased significantly, with a significant difference (P < 0.01).

[0108] The effects of each test group on the total white blood cell count of rats are shown in Table 2.

[0109] Table 2

[0110]

[0111] Note: Compared with the negative control group, a P < 0.05; compared with the model control group, b P < 0.05;

[0112] It can be seen from the data in Table 2 that compared with the negative control group, the total white blood cell count of rats in the model control group increased significantly, with a significant difference (P < 0.05); compared with the model control group, the total white blood cell count of rats in the compound preparation group and the positive control group decreased significantly before and after administration, with a significant difference (P < 0.05).

[0113] The effects of each experimental group on rat lymphocytes are shown in detail in Table 3.

[0114] Table 3

[0115]

[0116]

[0117] Note: Compared with the negative control group, a P < 0.05; compared with the model control group, b P < 0.05;

[0118] It can be seen from the data in Table 3 that compared with the negative control group, the number of rat lymphocytes in the model control group increased significantly, with a significant difference (P < 0.05); compared with the model control group, the number of rat lymphocytes in the compound preparation group and the positive control group decreased significantly before and after administration, with a significant difference (P < 0.05).

[0119] The effects of each experimental group on rat cytokines are shown in Table 4.

[0120] Table 4

[0121]

[0122] Note: Compared with the negative control group, a P < 0.01; compared with the model control group, b P < 0.05;

[0123] It can be seen from the data in Table 4 that compared with the negative control group, the contents of interleukin-6 and tumor necrosis factor-α in the model control group of rats increased significantly, with a significant difference (P < 0.01); compared with the model control group, the contents of interleukin-6 and tumor necrosis factor-α in the compound preparation group and the positive control group of rats decreased significantly, with a significant difference (P < 0.05).

[0124] From the above results, it can be seen from Table 1 that the body weight of the rats taking the compound preparation increased on the 7th day, while the body weight of the rats in the model control group that did not take any medicine did not change significantly when compared on the 7th day with the 4th day, and the body weight of the rats in the positive control group taking aspirin also increased on the 7th day. Therefore, it shows that the throat discomfort symptoms of the rats taking the compound preparation in this example have been relieved.

[0125] At the same time, it can be seen from the data in Table 2, Table 3 and Table 4 that compared with the model control group, the total white blood cell count, lymphocyte count, interleukin-6 and tumor necrosis factor-α contents of the rats after taking the compound preparation all decreased, indicating that the inflammation of the rats' throats has been relieved.

[0126] In summary, the medicated and edible homologous compound preparation of the present invention can relieve throat discomfort and reduce throat inflammation, thereby providing a medicated and edible homologous compound preparation suitable for relieving throat discomfort. In addition, from Figure 1 It can be seen that the preparation method of the medicated and edible homologous compound preparation in this embodiment has a simple process and is easy to operate, which is conducive to industrial production.

[0127] The above are only the preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A medicine and food homologous compound preparation, characterized in that: The components of the medicine and food homologous compound preparation include polygonatum odoratum, jujube, licorice, ginger, semen sojae praeparatum, mint, perilla leaf, mulberry leaf, cassia seed, angelica dahurica, platycodon grandiflorum, Chinese olive, gardenia, radish seed, natural menthol, sorbitol, and erythritol.

2. The medicine and food homologous compound preparation according to claim 1, characterized in that: The components of the medicine and food homologous compound preparation include 10% - 25% polygonatum odoratum, 7% - 10% jujube, 5% - 8% licorice, 4% - 7% ginger, 4% - 7% semen sojae praeparatum, 3% - 6% mint, 3% - 6% perilla leaf, 2% - 5% mulberry leaf, 2% - 5% cassia seed, 2% - 5% angelica dahurica, 1% - 3% platycodon grandiflorum, 1% - 3% Chinese olive, 1% - 3% gardenia, 0.5% - 2% radish seed, 0.5% - 2% natural menthol, 10% - 15% sorbitol by weight percentage, and the rest is erythritol.

3. The medicine and food homologous compound preparation according to claim 2, characterized in that: The components of the medicine and food homologous compound preparation include 15% - 25% polygonatum odoratum, 8% - 10% jujube, 6% - 8% licorice, 5% - 7% ginger, 5% - 7% semen sojae praeparatum, 4% - 6% mint, 4% - 6% perilla leaf, 3% - 5% mulberry leaf, 3% - 5% cassia seed, 3% - 5% angelica dahurica, 2% - 3% platycodon grandiflorum, 2% - 3% Chinese olive, 2% - 3% gardenia, 0.5% - 1.5% radish seed, 0.5% - 1.5% natural menthol, 10% - 13% sorbitol by weight percentage, and the rest is erythritol.

4. The medicine and food homologous compound preparation according to claim 3, characterized in that: The components of the medicine and food homologous compound preparation include 20% polygonatum odoratum, 9% jujube, 7% licorice, 6% ginger, 6% semen sojae praeparatum, 5% mint, 5% perilla leaf, 4% mulberry leaf, 4% cassia seed, 4% angelica dahurica, 2.5% platycodon grandiflorum, 2.5% Chinese olive, 2.5% gardenia, 1.5% radish seed, 1.5% natural menthol, 12% sorbitol by weight percentage, and the rest is erythritol.

5. The preparation method of the medicine-food homologous compound preparation according to any one of claims 1 to 4, characterized in that, The preparation method includes: Respectively crushing, sieving the polygonatum odoratum, the jujube, the licorice, the ginger, the semen sojae praeparatum, the mint, the perilla leaf, the mulberry leaf, the cassia seed, the angelica dahurica, the platycodon grandiflorum, the Chinese olive, the gardenia, the radish seed and the erythritol, and then conducting the first mixing to obtain a mixed powder; Conducting the second mixing of the mixed powder with an adhesive to obtain wet granules; Drying the wet granules to obtain dry granules, and mixing the dry granules with the natural menthol and the sorbitol to obtain the medicine and food homologous compound preparation.

6. The preparation method of the medicine and food homologous compound preparation according to claim 5, characterized in that: The polygonatum odoratum, the jujube, the licorice, the ginger, the semen sojae praeparatum, the mint, the perilla leaf, the mulberry leaf, the cassia seed, the angelica dahurica, the platycodon grandiflorum, the Chinese olive, the gardenia, the radish seed are all sieved through an 80 - mesh sieve; and / or, The erythritol is sieved through a 40 - mesh sieve.

7. The preparation method of the medicine-food homologous compound preparation according to claim 5, wherein: The mixing time of the first mixing is 3 to 5 minutes; and / or, The mixing time of the second mixing is 18 to 25 minutes.

8. The preparation method of the medicine-food homologous compound preparation according to claim 5, wherein: The binder comprises an ethanol solution with a volume fraction of 75% to 95%.

9. The preparation method of the medicine-food homologous compound preparation according to claim 5, wherein: The drying temperature of the wet granules is 40 to 55 °C.

10. The use of the medicine-food homologous compound preparation according to any one of claims 1 to 4, wherein: The medicine-food homologous compound preparation is used for relieving throat discomfort.

Images