Device for detecting content of intermediate of sodium chloride injection

Abstract

The invention discloses a device for detecting the content of a sodium chloride injection intermediate, and relates to the technical field of pharmacy. Comprising a detection cup, a Raman spectrum detector, a U-shaped pipe and a gas filtering device, an opening is formed in the lower portion of the detection cup, the opening is sealed through a cover plate, a liquid inlet pipe, a liquid outlet pipe and the Raman spectrum detector are installed on the cover plate, a Raman probe of the Raman spectrum detector upwards extends into the detection cup, and the U-shaped pipe is connected with the gas filtering device. A U-shaped pipe is further installed on the cover plate, one end of the U-shaped pipe extends to the upper portion in the detection cup, and the other end of the U-shaped pipe is located outside the detection cup and provided with a gas filtering device; the quantity of bubbles generated in the process that liquid enters the detection device can be reduced, the situation that the bubbles are attached to the outer surface of a Raman probe of the Raman spectrum detector to affect the detection accuracy is avoided, meanwhile, the liquid inlet time is shortened, and the detection efficiency is improved.

Description

Technical Field

[0001] The present invention relates to the field of pharmaceutical technology, and particularly relates to a detection device for the content of intermediate of sodium chloride injection. Background Art

[0002] The intermediate of sodium chloride injection needs to be detected online by a Raman system. The liquid medicine is quantitatively pumped into a detection container by a peristaltic pump. The existing detection container usually uses a detection cup, on which a Raman detector is installed, and the probe of the detector is immersed in the internal liquid for detection. The following problems exist in the detection process: 1. The liquid in the detection container often does not soak the surface of the probe, and accurate detection cannot be carried out. Ensuring that the probe can be soaked by the liquid requires a large amount of samples, resulting in waste; 2. Since the detection container is in a sealed state, the liquid enters slowly or the amount of liquid entering is insufficient, affecting the detection time or detection accuracy, and the sample cannot be completely emptied when discharging the sample, and there will be sample residues; 3. When the liquid enters the detection container due to its own pressure and from top to bottom, the impact causes a lot of bubbles to be generated in the liquid medicine. The generated bubbles will adhere to the inner wall of the detection container and the surface of the probe, and the distribution is random. If bubbles adhere to the surface of the Raman probe head, it will affect the green light irradiation of the Raman probe and the capture of the water peak change signal, directly affecting the accuracy of the detection result. Summary of the Invention

[0003] The present invention is to solve the technical problem that when the content of the intermediate of sodium chloride injection is detected by a Raman system, a large number of bubbles will be generated in the detection device, the liquid inlet speed is slow or the amount is insufficient, resulting in affecting the detection accuracy and detection efficiency. The purpose is to provide a detection device for the content of the intermediate of sodium chloride injection, which can reduce the amount of bubbles generated during the process of the liquid entering the detection device, avoid the bubbles adhering to the outer surface of the Raman probe of the Raman spectrometer detector and affecting the detection accuracy, and at the same time shorten the liquid inlet time and improve the detection efficiency.

[0004] The present invention is realized by the following technical solutions:

[0005] A detection device for the content of the intermediate of sodium chloride injection includes a detection cup, a Raman spectrometer detector, a U-shaped tube and a gas filtration device;

[0006] The lower part of the detection cup has an opening, which is sealed by a cover plate. An inlet pipe, an outlet pipe and a Raman spectrometer detector are installed on the cover plate. The Raman probe of the Raman spectrometer detector extends upward into the detection cup. A U-shaped tube is also installed on the cover plate. One end of the U-shaped tube extends to the upper part inside the detection cup, and the other end of the U-shaped tube is located outside the detection cup and is installed with a gas filtration device.

[0007] Further, inside the detection cup, the top position of the U-shaped tube is higher than the top position of the Raman probe.

[0008] Further, one end of the U-shaped tube located outside the detection cup is higher than the other end located inside the detection cup.

[0009] Further, the gas filtering device is a waterproof filter membrane.

[0010] Further, the detection cup is fixedly connected to the cover plate through a fixing ring provided on the outer wall.

[0011] Further, a first fixing hole is formed in the fixing ring, a second fixing hole is formed in the cover plate, and a fixing member is passed through between the first fixing hole and the second fixing hole to realize the connection between the detection cup and the cover plate.

[0012] Further, a first temperature detector and a second temperature detector are also installed on the cover plate, and the temperature probes of the first temperature detector and the second temperature detector extend upward into the detection cup.

[0013] Further, a pH detector is also installed on the cover plate, and the pH electrode probe of the pH detector extends upward into the detection cup.

[0014] Further, an instrument installation hole is also formed in the cover plate.

[0015] Further, the liquid inlet pipe, the liquid outlet pipe, the Raman spectrometer, the pH detector, the first temperature detector, and the second temperature detector are all fixed in the instrument installation hole of the cover plate through connection joints.

[0016] Compared with the prior art, the present invention has the following advantages and beneficial effects:

[0017] 1. When the present invention performs detection, the sample gradually enters the detection cup from bottom to top through the liquid inlet pipe. On the one hand, it can make the detection cup not completely sealed, facilitating the inflow and outflow of the liquid, shortening the liquid inlet time, and improving the detection efficiency. On the other hand, since the liquid flows into the detection cup from bottom to top, the amount of bubbles during the liquid entry process can be reduced, avoiding bubbles from adhering to the outer surface of the Raman probe of the Raman spectrometer, and thus avoiding adhering to the acquisition optical path at the bottom of the Raman probe, ensuring the accuracy of the detection.

[0018] 2. The present invention is provided with a U-shaped tube, one end of which is connected to the inside of the detection cup and the other end is arranged outside the detection cup. When liquid enters, the gas in the detection cup can be discharged through the U-shaped tube. When the liquid is discharged, the external gas enters the inside of the detection cup through the U-shaped tube, avoiding the situation where the liquid cannot flow or the flow rate is slow due to the completely sealed state. At the same time, to avoid the influence of external unclean air on the internal environment of the detection cup, a gas filtering device is arranged at the external end of the U-shaped tube to filter the external air and prevent unclean air from entering the inside of the detection cup and polluting the internal environment. Description of the Drawings

[0019] The drawings described herein are used to provide a further understanding of the embodiments of the present invention, form a part of this application, and do not constitute a limitation to the embodiments of the present invention. In the drawings:

[0020] Figure 1 is a schematic diagram of the overall structure of the present invention;

[0021] Figure 2 is a schematic diagram of the internal structure of the present invention;

[0022] Figure 3 is a schematic diagram of the connection structure between the detection cup and the cover plate;

[0023] Figure 4 is a schematic diagram of the structure of the detection cup.

[0024] Marks in the drawings and corresponding component names:

[0025] 1 - Detection cup, 2 - Fixed ring, 201 - First fixing hole, 3 - Cover plate, 301 - Instrument installation hole, 302 - Second fixing hole, 4 - Liquid inlet pipe, 5 - First connection joint, 6 - Liquid outlet pipe, 7 - Second connection joint, 8 - Raman spectrometer detector, 9 - Third connection joint, 10 - pH detector, 11 - Fourth connection joint, 12 - First temperature detector, 13 - Fifth connection joint, 14 - Second temperature detector, 15 - Sixth connection joint, 16 - U-shaped tube, 17 - Gas filtering device. Detailed Embodiments

[0026] To make the objectives, technical solutions, and advantages of the present invention clearer and more understandable, the present invention will be further described in detail below in combination with the embodiments and the drawings. The illustrative embodiments of the present invention and their descriptions are only used to explain the present invention and do not constitute a limitation to the present invention.

[0027] In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. However, it will be apparent to one of ordinary skill in the art that: the present invention may be practiced without these specific details. In other instances, well-known structures, circuits, materials, or methods have not been specifically described in order to avoid obscuring the aspects of the present invention.

[0028] Throughout the specification, the mention of "one embodiment", "an embodiment", "an example", or "an example" means that a particular feature, structure, or characteristic described in connection with the embodiment or example is included in at least one embodiment of the present invention. Thus, the phrases "one embodiment", "an embodiment", "an example", or "an example" appearing throughout the specification do not necessarily all refer to the same embodiment or example. Additionally, the particular features, structures, or characteristics may be combined in any suitable combination and / or sub-combination in one or more embodiments or examples. Further, those of ordinary skill in the art should understand that the diagrams provided herein are for illustrative purposes only and are not necessarily drawn to scale. The term "and / or" used herein includes any and all combinations of one or more of the associated listed items.

[0029] In the description of the present invention, the indicated orientation or positional relationship is based on the orientation or positional relationship shown in the drawings, or the orientation or positional relationship in which the product of this application is customarily placed during use, or the orientation or positional relationship commonly understood by those skilled in the art. It is only for the convenience of describing the present application and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as a limitation of the present application.

[0030] Meanwhile, the terms "arranged", "assembled", "connected", and "coupled" should be understood in a broad sense. For example, it may be a fixed connection, a detachable connection, or an integral connection; it may be directly connected or indirectly connected through an intermediate medium, and it may be the internal communication of two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0031] Embodiment

[0032] This embodiment provides a detection device for the content of the intermediate of sodium chloride injection, as Figures 1 - 4 shown, including a detection cup 1, a Raman spectroscopy detector 8, a U-shaped tube 16, and a gas filtering device 17;

[0033] The lower part of the detection cup 1 has an opening, which is sealed by a cover plate 3. An inlet pipe 4, an outlet pipe 6 and a Raman spectroscopy detector 8 are installed on the cover plate 3. The Raman probe of the Raman spectroscopy detector 8 extends upward into the detection cup 1. A U-shaped tube 16 is also installed on the cover plate 3. One end of the U-shaped tube 16 extends to the upper part inside the detection cup 1, and the other end of the U-shaped tube 16 is located outside the detection cup 1 and is equipped with a gas filtration device 17.

[0034] When the present invention is performing detection, the sample gradually enters the detection cup 1 from bottom to top through the inlet pipe 4. On the one hand, it can make the detection cup 1 not completely sealed, facilitating the inflow and outflow of liquid, shortening the liquid inlet time, and improving the detection efficiency. On the other hand, since the liquid flows into the detection cup 1 from bottom to top, the amount of bubbles during the liquid entry process can be reduced, avoiding bubbles adhering to the outer surface of the Raman probe of the Raman spectroscopy detector 8, and thus avoiding adhering to the acquisition optical path at the bottom of the Raman probe, ensuring the accuracy of the detection.

[0035] The present invention is provided with a U-shaped tube 16, with one end connected to the inside of the detection cup 1 and the other end arranged outside the detection cup 1. When the liquid enters, the gas inside the detection cup 1 can be discharged through the U-shaped tube. When the liquid is discharged, the external gas enters the inside of the detection cup 1 through the U-shaped tube, avoiding the situation where the liquid cannot flow or the flow rate is slow due to the completely sealed state. At the same time, to avoid the influence of external unclean air on the internal environment of the detection cup 1, a gas filtration device 17 is provided at the external end of the U-shaped tube 16 to filter the external air and prevent unclean air from entering the inside of the detection cup 1 and polluting the internal environment.

[0036] Among them, the gas filtration device 17 is a waterproof filter membrane, preferably made of PTFE material, which can play a role in waterproofing and gas filtration, preventing water in the external environment from entering the detection cup 1 and affecting the detection accuracy, and at the same time filtering the air entering the detection cup 1 to avoid affecting the environment inside the detection cup 1.

[0037] As Figure 1 and 2 shown, inside the detection cup 1, the top position of the U-shaped tube 16 is higher than the top position of the Raman probe. The height of the end of the U-shaped tube 16 located outside the detection cup 1 is higher than the height of the end located inside the detection cup 1. Inside the detection cup 1, the top position of the U-shaped tube 16 is almost close to the top inner wall of the detection cup 1, and its height is the highest compared to the probe positions of other instruments. In this way, it can ensure that when the liquid completely submerges the probes of each instrument, the air inside the detection cup 1 can be discharged. At the same time, the top position of the external U-shaped tube 16 is higher than the top position inside, so as to prevent liquid from flowing out from the external end of the U-shaped tube 16 and polluting the detection environment if liquid enters the U-shaped tube 16.

[0038] As Figure 3 and 4 shown, the test cup 1 is fixedly connected to the cover plate 3 through a fixing ring 2 provided on the outer wall. To facilitate the connection between the test cup 1 and the cover plate 3, a fixing ring 2 is provided outside the test cup 1; a first fixing hole 201 is formed on the fixing ring 2, a second fixing hole 302 is formed on the cover plate 3, and a fixing member is passed through between the first fixing hole 201 and the second fixing hole 302 to realize the connection between the test cup 1 and the cover plate 3. During installation, the test cup 1 and the cover plate 3 are connected by passing a bolt through the first fixing hole 201 and the second fixing hole 302.

[0039] As Figure 1 and 2 shown, a first temperature detector 12 and a second temperature detector 14 are further installed on the cover plate 3, and the temperature probes of the first temperature detector 12 and the second temperature detector 14 extend upward into the test cup 1. Since temperature has a great influence on the accuracy of the test results (it will affect the water seal), two temperature detectors are provided to detect the internal liquid, thereby reducing the influence of temperature change on the test results.

[0040] A pH detector 10 is further installed on the cover plate 3, and the pH electrode probe of the pH detector 10 extends upward into the test cup 1. The pH value of the internal liquid can be detected through the pH electrode probe of the pH detector 10 to ensure that the pH value is under the required conditions.

[0041] As Figure 1 and 3 shown, an instrument mounting hole 301 is further formed on the cover plate 3, and the liquid inlet pipe 4, the liquid outlet pipe 6, the Raman spectroscopy detector 8, the pH detector 10, the first temperature detector 12 and the second temperature detector 14 are all fixedly installed in the instrument mounting hole 301 of the cover plate 3 through connection joints.

[0042] Among them, the liquid inlet pipe 4 is fixedly installed in the instrument mounting hole 301 of the cover plate 3 through a first connection joint 5, the liquid outlet pipe 6 is fixedly installed in the instrument mounting hole 301 of the cover plate 3 through a second connection joint 7, the Raman spectroscopy detector 8 is fixedly installed in the instrument mounting hole 301 of the cover plate 3 through a third connection joint 9, the pH detector 10 is fixedly installed in the instrument mounting hole 301 of the cover plate 3 through a fourth connection joint 11, the first temperature detector 12 is fixedly installed in the instrument mounting hole 301 of the cover plate 3 through a fifth connection joint 13, and the second temperature detector 14 is fixedly installed in the instrument mounting hole 301 of the cover plate 3 through a sixth connection joint 15.

[0043] Finally, it should be noted that: The above specific embodiments are only used to elaborate in detail the purpose, technical solution and beneficial effects of the present invention. It should be understood that the above description is only the specific implementation manners of the present invention and is not used to limit the protection scope of the present invention; Although the present invention has been described in detail with reference to the above specific embodiments, those of ordinary skill in the art should understand that they can still modify the technical solutions recorded in the above embodiments, or perform equivalent replacements or improvements on some or all of the technical features; And these modifications, equivalent replacements and improvements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention, and they should all be covered within the scope of the claims and the description of the present invention.

Claims

1. A detection device for the content of the intermediate of sodium chloride injection, characterized in that, It includes a detection cup (1), a Raman spectroscopy detector (8), a U-shaped tube (16) and a gas filtration device (17); The lower part of the detection cup (1) has an opening, which is sealed by a cover plate (3). An inlet pipe (4), an outlet pipe (6) and a Raman spectroscopy detector (8) are installed on the cover plate (3). The Raman probe of the Raman spectroscopy detector (8) extends upward into the detection cup (1). A U-shaped tube (16) is also installed on the cover plate (3). One end of the U-shaped tube (16) extends to the upper part inside the detection cup (1), and the other end of the U-shaped tube (16) is located outside the detection cup (1) and is equipped with a gas filtration device (17).

2. The detection device for the content of the intermediate of sodium chloride injection according to claim 1, characterized in that, Inside the detection cup (1), the top position of the U-shaped tube (16) is higher than the top position of the Raman probe.

3. The detection device for the content of the intermediate of sodium chloride injection according to claim 1, characterized in that, The height of the end of the U-shaped tube (16) located outside the detection cup (1) is higher than the height of the other end located inside the detection cup (1).

4. The detection device for the content of the intermediate of sodium chloride injection according to claim 1, characterized in that, The gas filtration device (17) is a waterproof filter membrane.

5. The detection device for the content of the intermediate of sodium chloride injection according to claim 1, characterized in that, The detection cup (1) is fixedly connected to the cover plate (3) through a fixing ring (2) provided on the outer wall.

6. The detection device for the content of the intermediate of sodium chloride injection according to claim 5, characterized in that, A first fixing hole (201) is formed in the fixing ring (2), and a second fixing hole (302) is formed in the cover plate (3). A fixing member is passed through between the first fixing hole (201) and the second fixing hole (302) to realize the connection between the detection cup (1) and the cover plate (3).

7. A detection device for the content of intermediate in sodium chloride injection according to any one of claims 1-6, characterized in that, A first temperature detector (12) and a second temperature detector (14) are also installed on the cover plate (3). The temperature probes of the first temperature detector (12) and the second temperature detector (14) extend upward into the detection cup (1).

8. The detection device for the content of the intermediate of sodium chloride injection according to claim 7, wherein, A pH detector (10) is also installed on the cover plate (3). The pH electrode probe of the pH detector (10) extends upward into the detection cup (1).

9. The detection device for the content of the intermediate of sodium chloride injection according to claim 8, characterized in that, An instrument installation hole (301) is also formed in the cover plate (3).

10. A detection device for the content of the intermediate of sodium chloride injection according to claim 9, characterized in that, The inlet pipe (4), the outlet pipe (6), the Raman spectroscopy detector (8), the pH detector (10), the first temperature detector (12) and the second temperature detector (14) are all fixed in the instrument installation hole (301) of the cover plate (3) through connection joints.

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