A method of alleviating high starch-induced liver damage and glucose metabolism disorder in a seabass

By adding mulberry leaf polysaccharides to sea bass feed, the problems of liver damage and glucose metabolism disorders caused by high starch feed were solved, resulting in improved growth performance, improved liver health and blood sugar regulation, and reduced breeding costs.

CN120304505BActive Publication Date: 2026-06-09CHANGSHA UNIVERSITY +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CHANGSHA UNIVERSITY
Filing Date
2025-03-31
Publication Date
2026-06-09

AI Technical Summary

Technical Problem

Existing technologies are insufficient to effectively alleviate liver damage and glucose metabolism disorders in sea bass caused by high-starch feed, leading to decreased growth performance and deteriorating health. Furthermore, existing improvement measures are costly or have limited effectiveness.

Method used

Adding mulberry leaf polysaccharides to sea bass feed at a ratio of 2%-6%, and feeding them at specific times and cycles, can regulate the liver health and glucose metabolism of sea bass. By activating the PI3K/Akt signaling pathway, it can promote insulin secretion and glycogen synthesis, thereby optimizing the glucose metabolism pathway.

Benefits of technology

It significantly improves the growth performance of sea bass, enhances liver health, regulates blood sugar levels, reduces inflammation, optimizes glucose metabolism, reduces liver fat accumulation, and restores the fish to a healthy state.

✦ Generated by Eureka AI based on patent content.

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Abstract

This invention relates to the field of biotechnology, and more particularly to a method for alleviating high-starch-induced liver damage and glucose metabolism disorders in sea bass. The feed formulation proposed in this invention comprises 20%-22% cassava starch and 2%-6% mulberry leaf polysaccharides, among other components. This application discloses that mulberry leaf polysaccharides and the high starch content in the feed form a highly efficient synergistic effect, significantly improving the growth performance of sea bass, effectively reducing the accumulation of glycogen and fat in the liver, and significantly improving liver health. Simultaneously, it optimizes the blood glucose regulation capacity of sea bass, alleviates insulin resistance caused by a high-starch diet, and enhances insulin sensitivity. Furthermore, by activating mechanisms such as the PI3K / Akt signaling pathway, it optimizes the glucose metabolism pathway and promotes efficient energy utilization. The feed formulation of this invention is economical and efficient, providing solid scientific support for the healthy aquaculture of sea bass and powerfully promoting the sustainable development of aquaculture.
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