Prebiotics and metabiotics composition for improving self-protection capacity of whole body and preparation method of prebiotics and metabiotics composition for improving self-protection capacity of whole body

Abstract

The invention belongs to the technical field of health-care products, and particularly relates to a prebiotic and postbiotic composition for improving the self-protection capacity of the whole body and a preparation method of the prebiotic and postbiotic composition. The self-protection force is the self-repairing and self-rebuilding capability of a human body, is reflected in the disease resisting capability, and also comprises the self-repairing and self-rebuilding capability after the body is injured by diseases. The strength of the self-protection force directly affects the resistance and the restoring force of a human body to diseases. In the prior art, no related prebiotic and postbiotic composition capable of improving the self-protection capacity of the whole body is disclosed. The invention discloses a prebiotic and postbiotic composition capable of improving self-protecting power of a whole body and a preparation method of the prebiotic and postbiotic composition. According to the composition, the three prebiotics, the two metabiotics, the two organic acids, the six herbal components and the sweetening agent are combined to complement each other, and the self-protection ability of the whole body is improved through coordination. The composition also has the characteristics of high stability, good uniformity, good taste and wide applicable population.

Description

Technical Field

[0001] The present invention belongs to the technical field of health care products, and particularly relates to a prebiotic and postbiotic composition for enhancing the body's overall self-protection ability and its preparation method Background Art

[0002] Self-protection ability is the body's ability to self-repair and self-rebuild. It is not only reflected in the ability to resist diseases, but also includes the ability to self-repair and rebuild after the body is damaged by diseases. The strength of self-protection ability directly affects the body's resistance and recovery ability to diseases. Immunity refers to the ability of the body's immune system, which kills germs by producing defense cells such as white blood cells, macrophages, T cells, and NK cells. People with strong immunity can effectively prevent diseases and recover faster after getting sick. It can be seen that the content covered by self-protection ability is wider and has a greater impact than immunity. There is not much research on improving the body's overall self-protection ability in the prior art, and it is not comprehensive

[0003] In 2022, "CN 115531251A" disclosed a product and application of the water vitamin chain special research combination technology for multi-link water locking and moisturizing to maintain the skin barrier and enhance the skin's self-protection ability. The technical solution adopted is: components such as squalene, shea butter, hyaluronic acid, hydrolyzed collagen, and ceramide are prepared by a mixing method. The beneficial effects of this invention are: The product for skin water locking, moisturizing, repairing the barrier and enhancing the skin's self-protection ability is easily absorbed by the human epidermis, strengthens the skin's moisturizing ability, improves the skin's moisturizing effect, establishes a barrier for the skin, and has the effects of promoting epidermal cell regeneration and repairing the skin water film. It repairs and moisturizes damaged skin, can form a protective film on the skin surface, and can keep the skin moist and tender. It has a strong "water locking" effect, making the skin shiny, smooth, and more radiant. This composition has the problem of a narrow scope of action in enhancing self-protection ability

[0004] In summary, the existing compositions for enhancing self-protection ability generally have problems such as a narrow scope of action, poor uniformity, and poor stability Summary of the Invention

[0005] The technical problem to be solved by the present invention: The existing compositions for enhancing self-protection ability can only enhance local self-protection ability, and have problems of poor uniformity and poor stability

[0006] The present invention provides a prebiotic and postbiotic composition for enhancing the body's overall self-protection ability, and the composition includes prebiotics, postbiotics, organic acids, sweeteners, and herbal components

[0007] Among them, the mass ratio of the prebiotics, postbiotics, organic acids, sweeteners, and herbal components is: 45-55:15-25:0.5-2:0.2-1:25-35

[0008] The present invention provides a composition for enhancing the body's self - protection ability through the compounding of prebiotics, postbiotics, organic acids, sweeteners, and herbal components. As a dietary supplement, prebiotics are indigestible food ingredients that have beneficial effects on the host by selectively stimulating the growth and activity of bacteria in one or several colonies, thereby improving the host's health. Postbiotics are the collective term for beneficial bacterial components after the processing of probiotics, including bacterial cells and metabolites. The selected postbiotics have a better immune - enhancing ability than the original live bacteria and still retain high physiological activity even after being treated by high temperature or gastrointestinal digestive juices. The organic acids described in the present invention are important organic molecules in organisms and can participate in functions such as constructing cell structures, regulating the metabolic processes of organisms, and transmitting signals. Sweeteners are food additives that impart sweetness to food or feed, improve the quality of food, and meet people's requirements for food flavor. There are extremely many categories and varieties of herbal components, generally referring to the parts obtained from plants that have the function of regulating the human body's functions. Through the compounding of the above five types of substances, the present invention prepares a composition for enhancing the body's self - protection ability.

[0009] Preferably, the prebiotics include stachyose, yeast β - glucan, and galactooligosaccharides; the mass ratio of stachyose, yeast β - glucan, and galactooligosaccharides is 40 - 50:1 - 5:1 - 10.

[0010] Among them, the effects of various prebiotics are as follows:

[0011] Stachyose: Increase the growth of Bifidobacterium, improve digestion, and relieve constipation;

[0012] Yeast β - glucan: Increase antibodies, eliminate toxins, and repair cells;

[0013] Galactooligosaccharides: Increase the growth of beneficial bacteria, promote digestion and absorption, and enhance intestinal health.

[0014] When the mass ratio of stachyose, yeast β - glucan, and galactooligosaccharides is 40 - 50:1 - 5:1 - 10, they have the best effect of comprehensively increasing the growth of beneficial bacterial flora, promoting micro - ecological balance, maintaining the intestinal barrier, eliminating toxins, and increasing antibodies.

[0015] Preferably, the postbiotics include edible inactivated yeast and dunaliella polysaccharide; the mass ratio of edible inactivated yeast and dunaliella polysaccharide is 15 - 20:1 - 5.

[0016] Among them, the effects of various postbiotics are as follows:

[0017] Edible inactivated yeast: Balance immunity, improve allergies, resist inflammation, and improve constipation;

[0018] Dunaliella polysaccharide: Antioxidant, improve the intestine, antiviral, and accelerate metabolism.

[0019] When the mass ratio of the edible inactive yeast to the dunaliella salina polysaccharide is 15-20:1-5, it has the best immune balance, regulates the levels of IgA and IgE, resists inflammation, alleviates various respiratory infection symptoms, regulates immune response, alleviates allergic symptoms, reduces histamine-induced skin inflammatory response, and increases beneficial bacteria to improve constipation symptoms.

[0020] Preferably, the organic acids include N-acetylneuraminic acid and taurine; the mass ratio of N-acetylneuraminic acid to taurine is 0.1-1.0:0.1-1.0.

[0021] Among them, the effects of the various organic acids are as follows:

[0022] N-acetylneuraminic acid: It is a neurotransmitter of gangliosides and has the effect of "inducing" invading pathogens. It is the binding site of influenza virus in mucus cells and can prevent virus invasion as the receptor of influenza virus.

[0023] Taurine: It has the effects of anti-inflammatory, analgesic, maintaining the balance of matrix osmotic pressure, maintaining normal visual function, regulating cellular calcium balance, lowering blood sugar, regulating nerve conduction, participating in endocrine activities, regulating lipid digestion and absorption, increasing cardiac contractility, protecting myocardial cells, improving the body's immunity, and enhancing the antioxidant capacity of cell membranes.

[0024] When the mass ratio of N-acetylneuraminic acid to taurine is 0.1-1.0:0.1-1.0, it has the best effects of improving the body's immunity, promoting memory development, resisting virus invasion, anti-inflammatory and analgesic, preventing cold and reducing fever, and maintaining normal visual function.

[0025] Preferably, the sweetener is selected from at least one of mogroside, stevioside, and disodium glycyrrhizinate.

[0026] Among them, the effects of the various sweeteners are as follows:

[0027] Mogroside: Clearing heat and moistening the lungs, lubricating the intestines and promoting defecation, anti-cold;

[0028] Stevioside: Low calorie value and pure sweetness;

[0029] Disodium glycyrrhizinate: Enhancing immunity, lowering blood lipid, protecting the liver, and anti-inflammatory.

[0030] The above three sweeteners are all of natural origin and have the characteristics of high safety. Adding sweeteners to the composition of the present invention can improve the taste of the composition and is more friendly to children and diabetic patients.

[0031] Preferably, the herbal component includes elderberry powder, acerola cherry powder, mulberry powder, sophora flower powder, turmeric powder and apple powder; the mass ratio of elderberry powder, acerola cherry powder, mulberry powder, sophora flower powder, turmeric powder and apple powder is 1-8:1-5:1-5:0.5-2:0.5-2:15-25.

[0032] Among them, the effects of the various herbal components are as follows:

[0033] Elderberry powder: inhibits the reproduction of pathogenic bacteria, enhances immunity, has anti-inflammatory effects, and relieves cold symptoms;

[0034] Acerola cherry powder: aids digestion and supplements minerals;

[0035] Mulberry powder: has antioxidant, anti-inflammatory and anti-infective effects;

[0036] Sophora flower powder: has antiviral effects, scavenges free radicals, clears the liver and purges fire, relieves headache and dizziness, and alleviates respiratory symptoms;

[0037] Turmeric powder: interrupts the inflammatory response, scavenges oxygen free radicals, and protects the liver and kidneys;

[0038] Apple powder: clears heat and moistens the lungs, lubricates the intestines and promotes defecation, and resists colds;

[0039] The herbal component includes fruits, flowers, rhizomes, etc. It can disperse wind pathogens, lower the lung qi, reach the limbs, regulate the five internal organs, and help the overall immune balance. Among them, the combined use of elderberry powder, acerola cherry powder, turmeric powder and sophora flower powder has antibacterial, antiviral and enhanced detoxification effects. The combined use of apple powder and mulberry powder has the effects of moistening the lungs, generating body fluid, nourishing yin, calming the nerves, repairing itself and enhancing each other.

[0040] The present invention also discloses a preparation method of a prebiotic and postbiotic composition for improving the overall self-protection ability, which specifically includes the following steps:

[0041] (1) Weigh each component according to the mass ratio of the prebiotic and postbiotic composition for improving the overall self-protection ability described in any one of the above;

[0042] (2) Put drinking water into an emulsifying kettle, and successively put the herbal components except apple powder, prebiotics, postbiotics, organic acids and sweeteners. Under the protection of inert gas, turn on the high-speed shearing device of the emulsifying kettle for high-speed shearing and mixing to form a suspension;

[0043] (3) Filter the suspension and perform high-pressure homogenization to form a homogeneous liquid;

[0044] (4) Spray-dry the homogeneous liquid in a spray drying tower with an agglomeration function to form the composition;

[0045] Among them, during the spray drying process described in step (4), after the apple powder is mixed with the fine powder generated by spray drying, it re-enters the spray drying tower to achieve the agglomeration function described above.

[0046] In the preparation method of the present invention, first, each component is weighed according to the mass ratio of the prebiotics and postbiotics composition for enhancing the body's overall self-protection ability as described above for material preparation; then, drinking water is put into an emulsifying kettle, and other herbal components except apple powder, prebiotics, postbiotics, organic acids, and sweeteners are put in sequentially. Under the protection of inert gas, the high-speed shearing device of the emulsifying kettle is turned on for high-speed shearing and mixing to form a suspension. Here, the temperature of the drinking water is preferably 35-45°C, and the feeding amount of the drinking water needs to control the solid content of the suspension at 35-45%. A high solid content of the suspension can reduce the energy consumption of spray drying, but the particle size of the obtained composition will be relatively large due to the high viscosity of the suspension. The high-speed shearing and mixing here is to fully disperse the insoluble components in the suspension in the form of solid-in-water into the water phase. To obtain a uniform suspension, the impeller linear velocity of the high-speed shearing device during the shearing and mixing process needs to be controlled above 10 m / s. For a system with a high solid content and high viscosity, a dispersion disc can be used; for a system with a low solid content and low viscosity, a stator-rotor shearing device can be used; then, the suspension is filtered and homogenized under high pressure to form a homogeneous liquid. High-pressure homogenization can further crush the tiny particles or flocs in the suspension into finer particles, which can eliminate the particle feeling when the composition is taken orally; finally, the homogeneous liquid is spray-dried in a spray drying tower with an agglomeration function to form the composition. Among them, during the spray drying process described in step (4), the apple powder is mixed with the fine powder generated by spray drying and then re-entered into the spray drying tower to achieve the agglomeration function. The present invention conducts the spray drying process of the homogeneous liquid in a spray drying tower with an agglomeration function, and its basic principle is: the homogeneous liquid is pressurized by a high-pressure spray pump to reach several MPa, and then enters the atomizer nozzle and is sprayed into the internal cavity of the spray drying tower in the form of tiny droplets from the upper part of the spray drying tower. After the tiny droplets exchange heat and mass with the hot air flow, the dried composition is obtained and falls into the built-in fluidized bed of the spray drying tower. The material in the built-in fluidized bed is further dried by hot air and then enters the external fluidized bed. The fine powder in the material is blown up by the air flow entering the external fluidized bed and finally carried to the vicinity of the atomizer of the spray drying tower and adhered to the newly sprayed tiny droplets. This process is carried out cyclically, so that the finally obtained composition is a fluffy large particle formed by a large number of tiny particles adhering together. Such large particles are easy for water molecules to enter the inside of the fluffy large particles during the process of preparing the drink by dissolving in water, accelerating the dissolution process and realizing the instant solubility function. The present invention creatively mixes the apple powder and the fine powder obtained by drying in the external fluidized bed and then re-enters the spray drying tower and is captured on the surface of the tiny liquid sprayed by the atomizer to obtain a dry powder with a multi-layer structure. The apple powder is coated on the outermost layer of the microparticles as a protective agent, and this structure is beneficial to improving the stability of the internal prebiotics, postbiotics, organic acids, etc. Due to the existence of a large proportion of fine powder circulation process inside the spray drying tower, compared with the prior art, the distribution of active components in the finally obtained composition is more uniform. The fine powder generated by spray drying can be mixed with the main product and used as the product.

[0047] Preferably, the solid content of the suspension in step (2) is controlled to be 35-45%, and the temperature of the high-speed shearing and mixing process in step (2) is controlled to be 35-45°C.

[0048] If the solid content of the suspension is low, the energy consumption during the spray drying process is high; if the solid content of the suspension is high, the energy consumption during the spray drying process is low, but the viscosity of the suspension is high, and the particle size of the composition obtained by spray drying is large. If the temperature of the high-speed shearing and mixing process is low, the viscosity is high, and the particle size of the composition obtained by spray drying is large; if the temperature of the high-speed shearing and mixing process is high, it is not conducive to maintaining the stability of the active ingredient. Through comparative experiments, the inventors determined that the optimal solid content of the suspension is 35-45%, and the temperature of the high-speed shearing and mixing process is 35-45°C.

[0049] Preferably, the pressure of the high-pressure homogenization process in step (3) is controlled to be 25-35 MPa. The lower the pressure of the high-pressure homogenization process, the smaller the temperature rise of the homogenized liquid, which is more beneficial to maintaining the stability of the active ingredient. However, due to the small temperature rise of the homogenized liquid and high viscosity, it is not conducive to reducing the particle size of the homogenized liquid. The higher the pressure of the high-pressure homogenization process, the greater the temperature rise of the homogenized liquid, which is more unfavorable to maintaining the stability of the active ingredient. However, due to the large temperature rise of the homogenized liquid and low viscosity, it is more favorable to reducing the particle size of the homogenized liquid. Through optimization, the inventors found that a pressure of 25-35 MPa in the high-pressure homogenization process is the best combination.

[0050] Preferably, the spray drying tower in step (4) has a main air inlet and an internal fluidized bed air inlet, and the air temperature of the main air inlet and / or the internal fluidized bed air inlet is controlled to be 80-100°C. The spray drying process of the suspension is carried out in a spray drying tower with an internal fluidized bed in the present invention. This method can reduce the temperature difference between the hot air and the material, reducing the risk of high-temperature deterioration of the composition. And the thermal efficiency of the entire spray drying process is higher. Different from the general spray drying process, the present invention controls the air temperature of the main air inlet and / or the internal fluidized bed inlet air to be 80-100°C. The composition is dried by adjusting the amount of hot air. When the present invention is specifically implemented, the spray drying process of the suspension can be carried out in a spray drying system with an internal fluidized bed and an external fluidized bed, which can further improve the drying efficiency. Setting an external fluidized bed can reduce the difficulty of realizing the agglomeration function.

[0051] In summary, the present invention discloses a prebiotic and postbiotic composition for improving the body's self-protection ability and its preparation method. The composition combines three prebiotics, two postbiotics, two organic acids, six herbal components, and a sweetener to complement each other and cooperate coordinately to improve the body's self-protection ability. Through an innovative preparation method, the composition has the characteristics of high stability, good uniformity, good taste, and a wide range of applicable populations. Detailed implementation mode

[0052] Figure 1 It is a schematic flow chart of a method for preparing a prebiotic and postbiotic composition that enhances the body's overall self - protection ability according to the present invention.

[0053] Among them: Mark 1 - First pressure blower; Mark 2 - First air conditioning box; Mark 3 - Second pressure blower; Mark 4 - Second air conditioning box; Mark 5 - Third pressure blower; Mark 6 - Third air conditioning box; Mark 7 - Suspension feed pipe; Mark 8 - Spray drying tower; Mark 9 - Atomizer; Mark 10 - Built - in fluidized bed; Mark 11 - Exhaust port; Mark 12 - Feeder; Mark 13 - Rotary valve; Mark 14 - External fluidized bed; Mark 15 - Apple powder feeding port; Mark 16 - Product outlet. The following combines the attached Figure 1 Describe the device of the present invention in detail.

[0054] From the Figure 1 It can be clearly seen from the schematic flow chart of the preparation method of the present invention that the main device for realizing the present invention is the spray drying tower 8. An atomizer 9 is provided at the center of the cavity of the spray drying tower 8, and the atomizer 9 is connected to the suspension feed pipe 7. The bottom of the spray drying tower 8 is provided with a built - in fluidized bed 10. During specific spray drying, the prepared suspension enters the atomizer 9 through the suspension feed pipe 7 and is sprayed out at high speed in a mist form from the small holes of the atomizer 9. The spray drying tower 8 has an exhaust port 11 and two air inlets. One of them is pressurized by the first pressure blower 1 and heated to a suitable temperature by the first air conditioning box 2 and then enters the vicinity of the middle part of the spray drying tower 8. The other is pressurized by the second pressure blower 3 and heated to a suitable temperature by the second air conditioning box 4 and then enters the vicinity of the built - in fluidized bed 10 at the bottom of the spray drying tower 8. A material outlet is provided on the side of the built - in fluidized bed 10, and the material is transported into the external fluidized bed 14 through the rotary valve 13 at the material outlet. The external fluidized bed 14 has an air inlet. The air is pressurized by the third pressure blower 5 and heated to a suitable temperature by the third air conditioning box 6 and then enters the external fluidized bed 14 to further heat the material entering the external fluidized bed 14, and the fine powder is transported into the vicinity of the atomizer 9 through the circulation pipe. A feeder 12 is provided on the circulation pipe, and the feeder 12 is provided with an apple powder feeding port 15. The apple powder can be mixed with the fine powder discharged from the external fluidized bed 14 through the feeder 12 and then transported into the vicinity of the atomizer 9 and captured by the tiny liquid sprayed out by the atomizer 9 to achieve the agglomeration function. The external fluidized bed 14 is provided with a product outlet 16, and a prebiotic and postbiotic composition that enhances the body's overall self - protection ability is obtained from here.

[0056] The present invention will be specifically described below through examples, but the present invention is not limited to these examples.

[0057] Example 1

[0058] (1) Charge 125.0 kg of drinking water at 40°C into the emulsifying kettle. Turn on the stator-rotor shearing device of the emulsifying kettle and set the rotor speed to 750 r / min. Sequentially charge 1.3 kg of elderberry powder, 1.2 kg of acerola cherry powder, 1.7 kg of mulberry powder, 1.6 kg of sophora japonica powder, 0.8 kg of turmeric powder, 42.5 kg of stachyose, 3.8 kg of yeast β-glucan, 4.5 kg of galactooligosaccharide, 16.5 kg of inactivated edible yeast, 3.5 kg of dunaliella salina polysaccharide, 0.7 kg of N-acetylneuraminic acid, 0.8 kg of taurine, 0.14 kg of mogroside V, 0.08 kg of stevioside, and 0.03 kg of disodium glycyrrhizinate into the emulsifying kettle. Under nitrogen protection, set the rotor speed to 2900 r / min, calculate the impeller linear velocity to be 22.7 m / s, control the internal temperature of the emulsifying kettle at 40°C, and perform high-speed shear mixing to form a suspension;

[0059] (2) Pump the suspension in the emulsifying kettle into a filter equipped with a 100-mesh sieve through a rotor pump and then homogenize it through a high-pressure homogenizer to obtain a homogenized liquid. Control the pressure of the high-pressure homogenizer at 28 MPa during the homogenization process;

[0060] (3) Turn on the first pressure blower and the first air conditioning box, set the outlet air volume of the first pressure blower to 115 NM 3 / h, and the outlet air temperature of the first air conditioning box to 85°C; turn on the second pressure blower and the second air conditioning box, set the outlet air volume of the second pressure blower to 20 NM 3 / h, and the outlet air temperature of the second air conditioning box to 85°C; turn on the third pressure blower and the third air conditioning box, set the air volume of the third pressure blower to 65 NM 3 / h, and the outlet air temperature of the third air conditioning box to 85°C;

[0061] (4) Turn on the rotor pump for the homogenized liquid, control the flow rate of the homogenized liquid at 80 kg / h, pump the homogenized liquid into a high-pressure spray pump, increase the pressure to 7.6 MPa through the high-pressure spray pump, and send it into an atomizer for spray drying;

[0062] (5) Pre-charge 22.5 kg of apple powder into the apple powder feeding port. While performing spray drying, feed the apple powder into the spray drying tower at a flow rate of 11.0 kg / h for spray drying. The feeding speed of the apple powder needs to ensure that the spray drying of the suspension is completed approximately 0.5 hours after the apple powder feeding is completed, and finally obtain the agglomerated composition.

[0063] Quality evaluation of the composition:

[0064] During the packaging process, a total of 5 bags are packaged, with an average of 20 kg per bag. The last bag is less than 20 kg and is packaged according to the actual quantity. One sample is taken from each bag as a sample for uniformity evaluation.

[0065] 1. Uniformity evaluation: The stachyose contents of 5 samples for uniformity evaluation were detected respectively, which were 41.36%, 42.77%, 43.14%, 42.22%, and 41.53% in sequence. The average content was 42.20%, the standard deviation was 0.77%, and the relative standard deviation was 1.82%.

[0066] 2. Stability evaluation:

[0067] After the remaining samples from the uniformity evaluation were evenly mixed in equal amounts, nitrogen was filled and the samples were placed at room temperature for 1 year. The detected stachyose content was 41.26%. The stachyose retention rate calculated based on the average content of 42.20% was 97.76%.

[0068] Example 2

[0069] The preparation process of Example 2 was basically the same as that of Example 1. The difference was that the feeding amount of drinking water was increased to 145 kg, and apple powder was fed into the spray drying tower at a flow rate of 9.8 kg / h for spray drying.

[0070] Quality evaluation of the composition:

[0071] 1. Uniformity evaluation: The stachyose contents of 5 samples for uniformity evaluation were detected respectively, which were 42.85%, 42.36%, 41.44%, 41.79%, and 41.87% in sequence. The average content was 42.06%, the standard deviation was 0.55%, and the relative standard deviation was 1.31%.

[0072] 2. Stability evaluation:

[0073] After the remaining samples from the uniformity evaluation were evenly mixed in equal amounts, nitrogen was filled and the samples were placed at room temperature for 1 year. The detected stachyose content was 40.14%. The stachyose retention rate calculated based on the average content of 42.06% was 95.43%.

[0074] Example 3

[0075] The preparation process of Example 3 was basically the same as that of Example 1. The difference was that the feeding amount of drinking water was reduced to 95 kg, and apple powder was fed into the spray drying tower at a flow rate of 13.4 kg / h for spray drying.

[0076] Quality evaluation of the composition:

[0077] 1. Uniformity evaluation: The stachyose contents of 5 samples for uniformity evaluation were detected respectively, which were 40.35%, 42.77%, 42.65%, 43.02%, and 42.69% in sequence. The average content was 42.30%, the standard deviation was 1.10%, and the relative standard deviation was 2.59%.

[0078] 2. Stability evaluation:

[0079] After the remaining samples that had completed the uniformity evaluation were evenly mixed in equal amounts, nitrogen was filled, and they were placed at room temperature for 1 year. The stachyose content was detected to be 41.76%. The stachyose retention rate calculated based on the average content of 42.30% was 98.73%.

[0080] Example 4

[0081] The preparation process of Example 4 was basically the same as that of Example 1, except that the homogenization pressure was adjusted to 25 MPa.

[0082] Quality evaluation of the composition:

[0083] 1. Uniformity evaluation: The stachyose contents of 5 samples for uniformity evaluation were detected respectively, which were 42.23%, 43.24%, 41.73%, 42.12%, and 40.58% in sequence. The average content was 41.98%, the standard deviation was 0.96%, and the relative standard deviation was 2.29%.

[0084] 2. Stability evaluation:

[0085] After the remaining samples that had completed the uniformity evaluation were evenly mixed in equal amounts, nitrogen was filled, and they were placed at room temperature for 1 year. The stachyose content was detected to be 40.57%. The stachyose retention rate calculated based on the average content of 41.98% was 96.64%.

[0086] Example 5

[0087] The preparation process of Example 5 was basically the same as that of Example 1, except that the homogenization pressure was adjusted to 35 MPa.

[0088] Quality evaluation of the composition:

[0089] 1. Uniformity evaluation: The stachyose contents of 5 samples for uniformity evaluation were detected respectively, which were 42.22%, 42.07%, 42.46%, 40.97%, and 41.58% in sequence. The average content was 41.86%, the standard deviation was 0.59%, and the relative standard deviation was 1.42%.

[0090] 2. Stability evaluation:

[0091] After the remaining samples that had completed the uniformity evaluation were evenly mixed in equal amounts, nitrogen was filled, and they were placed at room temperature for 1 year. The stachyose content was detected to be 40.88%. The stachyose retention rate calculated based on the average content of 41.86% was 97.66%.

[0092] Example 6

[0093] The preparation process of Example 6 is basically the same as that of Example 1, except that the feeding amount of apple powder is reduced to 15 kg, and the apple powder is fed into the spray drying tower at a flow rate of 7.3 kg / h for spray drying.

[0094] Quality evaluation of the composition:

[0095] 1. Uniformity evaluation: The stachyose contents of 5 uniformity evaluation samples were detected respectively, which were 43.47%, 44.31%, 43.92%, 46.02%, 46.21% in sequence, average content: 44.79%, standard deviation: 1.25%, relative standard deviation: 2.79%.

[0096] 2. Stability evaluation:

[0097] After the remaining samples after the uniformity evaluation were evenly mixed in equal amounts, the stachyose content was detected after being placed at room temperature under nitrogen for 1 year: 42.68%, and the stachyose retention rate calculated based on the average content of 44.79% was: 95.30%.

[0098] Example 7

[0099] The preparation process of Example 7 is basically the same as that of Example 1, except that the feeding amount of apple powder is increased to 25 kg, and the apple powder is fed into the spray drying tower at a flow rate of 12.2 kg / h for spray drying.

[0100] Quality evaluation of the composition:

[0101] 1. Uniformity evaluation: The stachyose contents of 5 uniformity evaluation samples were detected respectively, which were 41.41%, 41.28%, 42.01%, 41.58%, 41.01% in sequence, average content: 41.46%, standard deviation: 0.37%, relative standard deviation: 0.90%.

[0102] 2. Stability evaluation:

[0103] After the remaining samples after the uniformity evaluation were evenly mixed in equal amounts, the stachyose content was detected after being placed at room temperature under nitrogen for 1 year: 40.99%, and the stachyose retention rate calculated based on the average content of 41.46% was: 98.87%.

[0104] Example 8

[0105] The preparation process of Example 8 is basically the same as that of Example 1, except that the air temperatures of the first air conditioning box, the second air conditioning box, and the third air conditioning box are all increased to 100 °C.

[0106] Quality evaluation of the composition:

[0107] 1. Uniformity evaluation: The stachyose contents of 5 samples for uniformity evaluation were detected respectively, and they were 41.17%, 42.57%, 42.13%, 42.65%, and 43.35% in sequence. The average content was 42.37%, the standard deviation was 0.80%, and the relative standard deviation was 1.89%.

[0108] 2. Stability evaluation:

[0109] After the remaining samples from the uniformity evaluation were evenly mixed in equal amounts, nitrogen was filled and they were placed at room temperature for 1 year, and then the stachyose content was detected to be 41.36%. The stachyose retention rate calculated based on the average content of 42.37% was 97.61%.

[0110] Comparative Example 1

[0111] The preparation process of Comparative Example 1 was basically the same as that of Example 1. The difference was that 22.5 kg of apple powder was put into the emulsifying kettle together with other herbal components for shear mixing.

[0112] Quality evaluation of the composition:

[0113] 1. Uniformity evaluation: The stachyose contents of 5 samples for uniformity evaluation were detected respectively, and they were 42.86%, 40.12%, 43.54%, 42.97%, and 40.57% in sequence. The average content was 42.01%, the standard deviation was 1.55%, and the relative standard deviation was 3.69%.

[0114] 2. Stability evaluation:

[0115] After the remaining samples from the uniformity evaluation were evenly mixed in equal amounts, nitrogen was filled and they were placed at room temperature for 1 year, and then the stachyose content was detected to be 39.62%. The stachyose retention rate calculated based on the average content of 42.01% was 94.31%.

[0116] Comparative Example 2

[0117] The preparation process of Comparative Example 2 was basically the same as that of Example 1. The difference was that the feeding amount of drinking water was increased to 180 kg, and the apple powder was fed into the spray drying tower at a flow rate of 8.2 kg / h for spray drying.

[0118] Quality evaluation of the composition:

[0119] 1. Uniformity evaluation: The stachyose contents of 5 samples for uniformity evaluation were detected respectively, and they were 41.11%, 42.13%, 43.62%, 42.23%, and 42.16% in sequence. The average content was 42.25%, the standard deviation was 0.89%, and the relative standard deviation was 2.12%.

[0120] 2. Stability evaluation:

[0121] After the remaining samples with completed uniformity evaluation were evenly mixed in equal amounts, nitrogen was filled and the samples were placed at room temperature for 1 year. The detected stachyose content was 39.65%. The stachyose retention rate calculated based on the average content of 42.25% was 93.85%.

[0122] Comparative Example 3

[0123] The preparation process of Comparative Example 3 was basically the same as that of Example 1, except that the feeding amount of drinking water was reduced to 75 kg, and apple powder was fed into the spray drying tower at a flow rate of 15.8 kg / h for spray drying.

[0124] Quality evaluation of the composition:

[0125] 1. Uniformity evaluation: The stachyose contents of 5 samples for uniformity evaluation were detected respectively, which were 43.98%, 41.04%, 44.28%, 41.34%, and 40.03% in sequence. The average content was 42.13%, the standard deviation was 1.89%, and the relative standard deviation was 4.48%.

[0126] 2. Stability evaluation:

[0127] After the remaining samples with completed uniformity evaluation were evenly mixed in equal amounts, nitrogen was filled and the samples were placed at room temperature for 1 year. The detected stachyose content was 40.02%. The stachyose retention rate calculated based on the average content of 42.13% was 94.98%.

Claims

1. A prebiotic and postbiotic composition for enhancing the body's overall self-protection ability, characterized in that, The composition comprises prebiotics, postbiotics, organic acids, sweeteners and herbal components; Among them, the mass ratio of the prebiotics, postbiotics, organic acids, sweeteners and herbal components is: 45-55:15-25:0.5-2:0.2-1:25-35.

2. The composition according to claim 1, wherein The prebiotics include stachyose, yeast β-glucan, galactooligosaccharides; the mass ratio of stachyose, yeast β-glucan, galactooligosaccharides is 40-50:1-5:1-10.

3. The composition according to claim 1, wherein The postbiotics include edible inactivated yeast and dunaliella salina polysaccharide; the mass ratio of the edible inactivated yeast, dunaliella salina polysaccharide is 15-20:1-5.

4. The composition according to claim 1, wherein The organic acids include N-acetylneuraminic acid and taurine; the mass ratio of N-acetylneuraminic acid, taurine is 0.1-1.0:0.1-1.

0.

5. The composition according to claim 1, characterized in that, The sweetener is selected from at least one of mogroside, stevioside, disodium glycyrrhizinate.

6. The composition according to claim 1, wherein The herbal components include elderberry powder, acerola cherry powder, mulberry powder, sophora japonica powder, turmeric powder and apple powder; the mass ratio of elderberry powder, acerola cherry powder, mulberry powder, sophora japonica powder, turmeric powder, apple powder is 1-8:1-5:1-5:0.5-2:0.5-2:15-25.

7. A preparation method of a prebiotic and postbiotic composition for enhancing the body's overall self-protection ability, characterized in that, Specifically, it includes the following steps: (1) Weigh each component according to the mass ratio of the prebiotic and postbiotic composition for enhancing the body's self-protection ability as described in any one of claims 1-6; (2) Put drinking water into an emulsifying kettle, and successively put the herbal components except apple powder, prebiotics, postbiotics, organic acids, sweeteners, and under the protection of inert gas, turn on the high-speed shearing device of the emulsifying kettle to carry out high-speed shearing and mixing to form a suspension; (3) The suspension is filtered and homogenized under high pressure to form a homogeneous liquid; (4) The homogeneous liquid is spray-dried in a spray drying tower with an agglomeration function to form the composition; Among them, in the spray drying process of step (4), after mixing the apple powder with the fine powder generated by spray drying, it re-enters the spray drying tower to achieve the agglomeration function.

8. The preparation method according to claim 7, wherein Control the solid content of the suspension described in step (2) to be 35-45%, and control the temperature of the high-speed shearing and mixing process described in step (2) to be 35-45°C.

9. The preparation method according to claim 7, characterized in that, Control the pressure of the high-pressure homogenization process described in step (3) to be 25-35 MPa.

10. The preparation method according to claim 7, wherein, The spray drying tower described in step (4) has a main air inlet and an internal fluidized bed air inlet, and control the air temperature of the main air inlet and / or the internal fluidized bed air inlet to be 80-100°C.

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