Application of venenum bufonis in preparation of male external delay article

Abstract

The invention provides an application of a venenum bufonis stock solution in preparation of a male delay product. The venenum bufonis is creatively dried, crushed and heated, and the venenum bufonis reacts with ethanol and is subjected to suction filtration, so that the skin sensitivity of the male penis is reduced, the comprehensive effect of delaying is achieved, and the venenum bufonis composition is mild and safe, has no adverse reaction, is easily available in raw material source and has market value.

Description

Technical Field

[0001] The present invention belongs to the technical field of daily-use male products, and particularly relates to an extraction process of an external delay agent stock solution and its application in male external delay products. Background Art

[0004] As a common animal-based Chinese medicinal material, bufotalin is the dried secretion of the parotid gland and skin glands of the Chinese toad or black-spectacled toad of the Bufonidae family; a large amount of bufotalin can also be extracted from the dried toad skins (the dried toad skins are not included in the 28 toxic Chinese medicinal materials and are Chinese medicinal materials included in the "National Chinese Medicine Decoction Pieces Processing Specification") that have not been collected for bufotalin on the market. Its many effects (such as analgesia and sedation) have been recorded in ancient medical books for a long time. The company found in the research on the action mechanism of bufotalin for many years that bufotalin has the effect of reducing the sensitivity of the male penis skin and prolonging male sexual function. At the same time, it was found that the higher the content of gamabufotalin, bufotalin, and bufalin in bufotalin, the greater the effect, while the higher the content of cinobufagin and resibufogenin does not necessarily result in a proportional increase in the effect. Based on this, the present invention was completed. Summary of the Invention

[0005] In a first aspect, the present invention provides a method for extracting bufotalin stock solution, and the method includes the following steps:

[0006] S01, Take an appropriate amount of bufotalin and put it into a drying oven for drying until its water content is less than 5%.

[0007] Preferably, the total content of gamabufotalin, bufotalin, and bufalin in the bufotalin in S01 shall not be less than 4.50%.

[0008] More preferably, the drying temperature of bufotalin is 60 degrees, and the continuous drying time is 12 hours to 24 hours.

[0009] S02, Put the dried bufotalin into a pulverizer for pulverization to obtain 80-mesh bufotalin powder.

[0010] S03, Place an appropriate amount of ethanol into a reaction kettle and heat it, and then put the 80-mesh bufotalin powder dried in S02 into the reaction kettle for heating reaction.

[0011] Preferably, an ethanol solution with a content of more than 95% is used.

[0012] More preferably, heat the ethanol in S03 to 75 to 78 degrees and carry out the heating reaction for one hour.

[0013] S04, Take out the bufotalin extract after the heating reaction, and perform vacuum filtration on the bufotalin extract to obtain bufotalin stock solution.

[0014] Second aspect, the present invention provides a male delaying preparation, and the preparation contains bufogenin stock solution.

[0015] Furthermore, the bufogenin stock solution is diluted 20 times with distilled water.

[0016] Furthermore, the delaying preparation contains other excipients.

[0017] The male external delaying preparation of the present invention significantly reduces the sensitivity of the male penis skin, achieves the comprehensive effect of delaying, and is mild and safe, and its raw materials are easily available. Specific embodiments

[0018] Examples

[0019] Example 1: Preparation of bufogenin stock solution

[0020] S01: Take 100 grams of bufotalin, bufotalin, and bufalin with a total content of not less than 4.50%, and put the bufogenin into a drying oven for drying for 12 hours to make the moisture content lower than 5%. Put the dried bufogenin into a pulverizer for pulverization to obtain 80-mesh bufogenin powder.

[0021] S02: Place 2000 grams of 95% ethanol solution in a reaction kettle and heat it, then put the 80-mesh bufogenin powder dried in S01 into the kettle and carry out a heating reaction for one hour.

[0022] S03: Take out the bufogenin extract after the heating reaction, and carry out vacuum filtration on the bufogenin extract to obtain bufogenin stock solution.

[0023] Example 2: Preparation of external delaying preparation

[0024] Dilute the bufogenin stock solution with 20 times of distilled water, and then add corresponding excipients to obtain the delaying preparation.

[0025] Example 3: Effect verification of the delaying preparation

[0026] Test method:

[0027] From January 2021 to April 30, 2025, we tested a total of 1200 males with an average age of 45 years old. They were divided into 20 groups with 60 people in each group. All the experiments were filled into spray bottles prepared with the same specification of the preparation, and all were sprayed three times on the glans corona of the penis 30 - 60 minutes before sexual intercourse.

[0028]

[0029]

[0030] Effect indicators: 1: Obvious effect (referring to an extension of sexual intercourse time by more than 5 minutes); 2: Good effect (referring to an extension of sexual intercourse time by more than 3 minutes); 3: Effect meets the standard (referring to an extension of sexual intercourse time by more than 1 minute); 4: No effect (referring to no delay effect).

[0031] Test results:

[0032] As shown in the above table, in Example 2, Example 6, and Example 16, one person had no effect, and the total number of people with no effect was 3. All the other examples were effective. Among them, those with obvious effects accounted for 51%; those with good effects accounted for 24.92%, those with effects meeting the standard accounted for 24.67%, and those with no effect accounted for 0.25%.

Claims

1. A toad venom stock solution, which is prepared by the following method: S1: Take an appropriate amount of toad venom and place it in a drying oven for drying to make its water content less than 5%; S2: Put the toad venom into a pulverizer for pulverization; S3: Place an appropriate amount of ethanol in a reaction kettle and heat it, then put the 80-mesh toad venom powder pulverized in S2 into the reaction kettle for heating reaction; S4: Filter the reaction solution after the reaction in S3 by suction filtration, and the filtrate is the toad venom stock solution.

2. According to the toad venom stock solution described in claim 1, in the toad venom described in S1, the total content of gamabufotalin, bufotalin, and bufalin shall not be less than 4.50%.

3. According to the toad venom stock solution described in claim 2, the drying temperature in S1 is 60 °C, and the drying time is 12 to 24 hours.

4. According to the toad venom stock solution described in claim 2, the ethanol described in S3 is characterized by a content of more than 95%.

5. According to the toad venom stock solution described in claim 2, the ethanol in S3 is heated for 1 hour, and the temperature is heated to 75 to 78 °C.

6. An application of the toad venom stock solution described in any one of claims 1-6 in the preparation of male delay products.

7. According to the application described in claim 6, the male product further contains one or more substances with functions of lubrication, antibacterial, cleaning, and promoting sexual function.

8. The application according to claim 7, characterized in that The male product is a spray.

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