Centrifugal drive liquid drop generation device

Abstract

The invention relates to the technical field of biological detection, and particularly discloses a centrifugal drive liquid drop generation device which comprises a base, a sample cavity, an air cavity and a liquid drop storage cavity which are arranged at intervals in the horizontal direction and sequentially communicated are formed in the base, and the base is further provided with a sample inlet channel communicated with the sample cavity; a transfer channel with one end communicated with the sample cavity is arranged in the base; a dispersed phase channel extending in the horizontal direction is formed in the base, and an outlet of the dispersed phase channel communicates with the air cavity; an inlet of the dispersed phase channel is communicated with the transfer channel; the liquid drop storage cavity is flat and is used for containing collected oil, an inlet of the liquid drop storage cavity is horizontally arranged and is communicated with the air cavity, the liquid drop storage cavity is filled with the collected oil under the capillary action, and the inlet of the liquid drop storage cavity directly faces an outlet of the dispersed phase channel. According to the arrangement, the volume of the generated liquid drops is smaller, and the detection cost can be saved.

Description

Technical Field

[0001] The present invention relates to the technical field of biological detection, and in particular, to a centrifugal-driven droplet generation device. Background Art

[0002] Emulsification technology is being extended to biological fields such as biotechnology, basic medical research, and diagnostics. By using droplets with precise size control, the accuracy and predictability of biological detection can be improved. Traditional emulsification technologies include mechanical mixing, colloid mixing, ultrasonic emulsifier mixing, and homogenizer mixing methods. Through gravity, a large number of emulsion droplets can be simply and quickly generated. However, the droplets produced by these methods are large in volume, increasing the detection cost.

[0003] Therefore, it is urgent to research a centrifugal-driven droplet generation device to solve the above problems. Summary of the Invention

[0004] The purpose of the present invention is to provide a centrifugal-driven droplet generation device to solve the problems in the prior art that the droplets prepared by gravity are large in volume and high in detection cost.

[0005] To achieve the above object, the present invention adopts the following technical solutions:

[0006] A centrifugal-driven droplet generation device, comprising:

[0007] A base, which has a sample chamber, an air chamber, and a droplet storage chamber arranged at intervals in the horizontal direction and communicating in sequence. The base also has a sample inlet channel communicating with the sample chamber;

[0008] A transfer channel is provided in the base, with one end communicating with the sample chamber;

[0009] A dispersed phase channel extending in the horizontal direction is provided in the base. The outlet of the dispersed phase channel communicates with the air chamber; the inlet of the dispersed phase channel communicates with the transfer channel;

[0010] The droplet storage chamber is flat and used for holding collection oil. The inlet of the droplet storage chamber is horizontally arranged and communicates with the air chamber, and the collection oil fills the droplet storage chamber under capillary action. The inlet of the droplet storage chamber is directly opposite to the outlet of the dispersed phase channel.

[0011] As an optional technical solution of the centrifugal-driven droplet generation device, the droplet storage chamber includes a main body portion and an outward expansion portion. The outward expansion portion communicates with the main body portion and is located at the inlet of the droplet storage chamber. In the vertical direction, the size of the outward expansion portion is larger than that of the main body portion;

[0012] And / or, a support member is provided in the droplet storage chamber. The support member extends in the vertical direction and supports inside the droplet storage chamber.

[0013] As an alternative technical solution of a centrifugal drive droplet generation device, there are two sample chambers, the two sample chambers are communicated with each other, and each sample chamber corresponds to a sample inlet channel, one of the sample inlet channels is used for adding liquid, and the other sample inlet channel is used for exhausting gas;

[0014] And / or, the sample inlet channel is vertically arranged and the opening faces upward.

[0015] As an alternative technical solution of a centrifugal drive droplet generation device, the transfer channel includes two branch channels extending along the length direction of the base and a summary channel extending along the width direction of the base, one ends of the two branch channels are respectively communicated with the two sample chambers, and the other ends are both communicated with the summary channel; one end of the dispersed phase channel is communicated with the summary channel.

[0016] As an alternative technical solution of a centrifugal drive droplet generation device, the base has a plurality of dispersed phase channels arranged at intervals along the width direction of the base, and each dispersed phase channel is communicated with the summary channel.

[0017] As an alternative technical solution of a centrifugal drive droplet generation device, the side wall of the sample chamber facing the dispersed phase channel includes an inclined surface and a stop surface, the stop surface is connected between the inclined surface and the front side wall of the sample chamber, and the branch channel is connected to the stop surface; along the tangential direction of the rotation direction, the inclined surface gradually moves away from the dispersed phase channel.

[0018] As an alternative technical solution of a centrifugal drive droplet generation device, along the liquid flow direction, the first upper end surface at the upper side of the outlet of the dispersed phase channel inclines downward; along the liquid flow direction, the first lower end surface at the lower side of the outlet of the dispersed phase channel inclines upward; the first upper end surface and the first lower end surface form the left side wall of the air chamber;

[0019] And / or, along the liquid flow direction, the second upper end surface at the upper side of the inlet of the droplet storage chamber inclines downward; along the liquid flow direction, the second lower end surface at the lower side of the inlet of the droplet storage chamber inclines upward; the second upper end surface and the second lower end surface form the right side wall of the air chamber.

[0020] As an alternative technical solution of a centrifugal drive droplet generation device, along the liquid flow direction, the front end surface at the outlet of the dispersed phase channel inclines backward, and the rear end surface at the outlet of the dispersed phase channel inclines forward.

[0021] As an alternative technical solution of a centrifugal drive droplet generation device, the base has an oil filling channel, one end of the oil filling channel is communicated with the air chamber, and the other end opens upward.

[0022] As an optional technical solution for a centrifugally driven droplet generating device, the refueling channel includes a horizontal portion and a vertical portion, the horizontal portion includes a connecting portion and a turning portion, the connecting portion is parallel to the width direction, and the turning portion is parallel to the length direction; along the liquid flow direction, the turning portion is located upstream of the connecting portion, and the turning portion and the vertical portion are connected.

[0023] The present invention has at least the following beneficial effects:

[0024] The invention provides a centrifugal driven liquid droplet generating device, which comprises a base, wherein the base is provided with a sample cavity, an air cavity and a liquid droplet storing cavity which are connected in sequence, wherein the base is provided with a transfer channel whose one end is connected with the sample cavity; wherein the base is provided with a dispersed phase channel extending along the length direction of the base, wherein the outlet of the dispersed phase channel is connected with the air cavity; wherein the inlet of the dispersed phase channel is connected with the transfer channel; wherein the liquid droplet storing cavity is flat and used for containing collected oil, wherein the inlet of the liquid droplet storing cavity is horizontally arranged and connected with the air cavity, and the collected oil is filled in the oil droplet storing cavity under the action of capillary action, and the inlet of the liquid droplet storing cavity is directly opposite to the outlet of the dispersed phase channel. When the centrifugal driven droplet generating device is placed on a rotating disk, when the rotating disk rotates, the centrifugal force generated can throw out the sample in the sample chamber, and the sample passes through the transfer channel and the dispersed phase channel in sequence to generate droplets. Under the action of inertia, the droplets pass through the air cavity and finally pass through the side surface of the collecting oil in the droplet storage cavity and enter the collecting oil, and finally suspend in the collecting oil. Among them, the side surface of the collecting oil that receives the droplets is perpendicular to the direction of the droplet movement. The size of the centrifugal force can be controlled by the rotation speed of the rotating disk, so that it is much greater than gravity, so that the volume of the generated droplets is smaller, which helps to save detection costs. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the following briefly introduces the drawings required for use in the description of the embodiments of the present invention. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the contents of the embodiments of the present invention and these drawings without paying any creative work.

[0026] Figure 1 Schematic diagram of the structure of a centrifugal driven droplet generating device in an embodiment of the present invention;

[0027] Figure 2 Schematic diagram of the internal structure of a centrifugal driven droplet generating device in an embodiment of the present invention;

[0028] Figure 3 A cross-sectional view from a first perspective of a centrifugally driven droplet generating device according to an embodiment of the present invention;

[0029] Figure 4It is a partial sectional view of the second perspective of the centrifugal driving droplet generation device in the embodiment of the present invention;

[0030] Figure 5 It is a schematic structural diagram of the structure layer in the embodiment of the present invention;

[0031] Figure 6 It is a schematic structural diagram of the bottom plate layer in the embodiment of the present invention.

[0032] In the figure:

[0033] 100, base; 110, sample chamber; 111, sample inlet channel; 112, inclined surface; 113, stop surface; 120, air chamber; 121, fuel filling channel; 1211, connecting part; 1212, turning part; 1213, vertical part; 130, droplet storage chamber; 131, main body part; 132, outward expansion part; 133, support member; 140, transfer channel; 141, branch channel; 142, summary channel; 150, dispersed phase channel; 151, first upper end surface; 152, first lower end surface; 153, front end surface; 154, rear end surface; 155, second upper end surface; 156, second lower end surface;

[0034] 101, structure layer; 1011, sample groove; 1012, transfer groove; 1013, dispersion groove; 1014, first air groove; 1015, droplet storage groove; 1016, fuel filling groove; 1017, first positioning groove; 102, bottom plate layer; 1021, second air groove; 1022, outward expansion groove; 1023, second positioning groove. Detailed implementation manners

[0035] Before explaining any embodiment of the present application in detail, it should be understood that the present application is not limited to the structural details and component arrangements set forth in the following description or shown in the above drawings.

[0036] In the present application, the terms "comprise", "include", "have" or any other variant thereof are intended to cover non-exclusive inclusion, such that a process, method, article or device comprising a series of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article or device. Without further limitation, an element defined by the phrase "comprising a..." does not exclude the presence of additional identical elements in the process, method, article or device comprising the element.

[0037] In this application, the term "and / or" describes the relationship between associated objects and represents three possible relationships. For example, A and / or B can represent three cases: A exists alone, both A and B exist simultaneously, and B exists alone. Additionally, in this application, the character " / " generally indicates that the associated objects before and after are in an "and / or" relationship.

[0038] In this application, the terms "connect", "combine", "couple", and "mount" can be direct connections, combinations, couplings, or mountings, or they can be indirect connections, combinations, couplings, or mountings. Here, for example, a direct connection means that two parts or components are connected together without an intermediate member, and an indirect connection means that two parts or components are each connected to at least one intermediate member, and these two parts or components are connected through the intermediate member. In addition, "connect" and "couple" are not limited to physical or mechanical connections or couplings and can include electrical connections or couplings.

[0039] In this application, those of ordinary skill in the art will understand that relative terms used in combination with a quantity or condition (such as "about", "approximately", "substantially", etc.) include the stated value and have the meaning indicated by the context. For example, such relative terms at least include the degree of error associated with the measurement of a specific value, tolerances caused by manufacturing, assembly, use, etc. associated with a specific value. Such terms should also be considered to disclose a range defined by the absolute values of two endpoints. Relative terms can refer to a plus or minus a certain percentage (such as 1%, 5%, 10% or more) of the indicated value. A numerical value without a relative term should also be disclosed as a specific value with a tolerance. Additionally, when expressing a relative angular positional relationship (such as substantially parallel, substantially perpendicular), "substantially" can refer to a plus or minus a certain number of degrees (such as 1 degree, 5 degrees, 10 degrees or more) from the indicated angle.

[0040] In this application, those of ordinary skill in the art will understand that the functions performed by a component can be performed by one component, multiple components, one part, or multiple parts. Similarly, the functions performed by a part can also be performed by one part, one component, or a combination of multiple parts.

[0041] In the present application, the terms "upper", "lower", "left", "right", "front", "back" and other directional words are described based on the orientation and positional relationship shown in the accompanying drawings, and should not be understood as limiting the embodiments of the present application. In addition, in the context, it is also necessary to understand that when it is mentioned that an element is connected to another element "upper" or "lower", it can not only be directly connected to another element "upper" or "lower", but also indirectly connected to another element "upper" or "lower" through an intermediate element. It should also be understood that directional words such as upper side, lower side, left side, right side, front side, back side, etc. not only represent the positive orientation, but can also be understood as the lateral orientation. For example, the bottom can include directly below, lower left, lower right, lower front, and lower back, etc.

[0042] like Figures 1 to 4 As shown, this embodiment provides a centrifugal driven droplet generating device to produce droplets with smaller volume and reduce the testing cost. The centrifugal driven droplet generating device includes a base 100, wherein the base 100 has a sample chamber 110, an air chamber 120 and a droplet storage chamber 130 arranged in a horizontal direction and connected in sequence, and the base 100 also has a sample inlet channel 111 connected to the sample chamber 110; the base 100 has a transfer channel 140 connected to the sample chamber 110 at one end; the base 100 has a dispersed phase channel 150 extending in a horizontal direction, the outlet of the dispersed phase channel 150 is connected to the air chamber 120; the inlet of the dispersed phase channel 150 is connected to the transfer channel 140; the droplet storage chamber 130 is flat and used to hold the collected oil, the inlet of the droplet storage chamber 130 is arranged horizontally and connected to the air chamber 120, and the collected oil is filled in the droplet storage chamber 130 under capillary action, and the inlet of the droplet storage chamber 130 is directly opposite to the outlet of the dispersed phase channel 150. The height of the droplet storage chamber 130 is 0.5 mm-2 mm, and the length and width of the droplet storage chamber 130 are both more than 20 times the height.

[0043] When in use, the centrifugal driven droplet generating device is placed on a rotating disk whose shaft extends in the vertical direction. The centrifugal force generated by the rotation of the rotating disk can throw out the sample in the sample chamber 110, and the sample generates droplets after passing through the transfer channel 140 and the dispersed phase channel 150 in sequence, that is, the sample forms droplets at the moment of leaving the dispersed phase channel 150 under the action of inertia and liquid surface tension. The droplets pass through the left surface of the collecting oil of the air cavity 120 and the droplet storage cavity 130, and enter the inside of the collecting oil, and are finally suspended in the collecting oil. Among them, the left surface of the collecting oil that receives the droplets is perpendicular to the direction of movement of the droplets, and the centrifugal force can be controlled by the rotation speed of the rotating disk, so that it is much greater than gravity, so that the volume of the generated droplets is smaller, which helps to save detection costs.

[0044] In this embodiment, the sample can be water. Under the action of centrifugal force, water droplets are generated after passing through the dispersed phase channel 150. The water droplets move under the action of centrifugal force, cross the air cavity 120, and then enter the droplet storage cavity 130. In other embodiments, the sample can also be other mixed liquids that can produce droplets.

[0045] To ensure that the droplets smoothly enter the droplet storage cavity 130, in the vertical direction, the inlet size of the droplet storage cavity 130 is larger than the outlet size of the dispersed phase channel 150.

[0046] When the rotating disk rotates and each dispersed phase channel 150 generates multiple droplets, to avoid accumulation, in some embodiments, the droplet storage cavity 130 includes a main body portion 131 and an outward expanding portion 132. The outward expanding portion 132 is connected to the main body portion 131 and is located at the inlet of the droplet storage cavity 130. In the vertical direction, the size of the outward expanding portion 132 is larger than that of the main body portion 131. The depth of the collected oil at the outward expanding portion 132 is greater than that at the main body portion 131 to accommodate more collected oil and cache more droplets. After stopping rotation, the droplets gradually disperse throughout the main body portion 131. It should be noted that the bottom of the inlet of the droplet storage cavity 130 is flush with the bottom of the dispersed phase channel 150; alternatively, the bottom of the inlet of the droplet storage cavity 130 is slightly lower than the bottom of the dispersed phase channel 150 to facilitate the generated droplets to smoothly cross the air cavity 120 and enter the droplet storage cavity 130 under the action of inertia. The bottom of the main body portion 131 is flush with the bottom of the inlet of the droplet storage cavity 130. The bottom of the outward expanding portion 132 is lower than the bottom of the main body portion 131.

[0047] To ensure the smoothness of droplet generation, along the liquid flow direction, the first upper end face 151 at the upper side of the outlet of the dispersed phase channel 150 slopes downward; along the liquid flow direction, the first lower end face 152 at the lower side of the outlet of the dispersed phase channel 150 slopes upward; the first upper end face 151 and the first lower end face 152 form the left side wall of the air cavity 120; this setting makes the attachment area of the droplets at the outlet of the dispersed phase channel 150 small, and it is easier for the droplets to separate from the internal liquid.

[0048] Further, along the liquid flow direction, the front end face 153 at the outlet of the dispersed phase channel 150 slopes backward, and the rear end face 154 at the outlet of the dispersed phase channel 150 slopes forward. Among them, both the front end face 153 and the rear end face 154 extend in the vertical direction. This setting makes the outlet of the dispersed phase channel 150 a square opening, further reducing the attachment area of the droplets here, which helps to further reduce the difficulty of droplet generation and facilitates the production of smaller droplets. Among them, with reference to Figures 2 to 4 As shown, the liquid flows from left to right, and the vertical direction is the up and down direction.

[0049] In some embodiments, along the liquid flow direction, the second upper end surface 155 at the upper side of the inlet of the droplet storage cavity 130 slopes downward; along the liquid flow direction, the second lower end surface 156 at the lower side of the inlet of the droplet storage cavity 130 slopes upward; the second upper end surface 155 and the second lower end surface 156 form the right side wall of the air cavity 120. This kind of setting helps to guide the droplets to smoothly enter the droplet storage cavity 130.

[0050] In some embodiments, there are two sample cavities 110, the two sample cavities 110 are communicated with each other, and each sample cavity 110 corresponds to a sample inlet channel 111. One of the sample inlet channels 111 is used to add liquid, and the other sample inlet channel 111 is used for exhausting air. This kind of setting improves the sample capacity and can also complete the smooth addition of the sample under the action of exhausting air.

[0051] The sample inlet channel 111 is arranged vertically and opens upward to facilitate adding the sample. When producing droplets, the rotation direction of the rotating disk is perpendicular to the extension direction of the sample inlet channel 111 to avoid the sample spilling out. Further, the sample inlet channel 111 is located at one end of the sample cavity 110 far from the transfer channel 140. When the base 100 is placed on the rotating disk, the sample inlet channel 111 is located at the axis position of the rotating disk, and the droplet storage cavity 130 is located at the edge position of the rotating disk.

[0052] To avoid residue of the sample in the sample cavity 110 during the rotation of the rotating disk, the side wall of the sample cavity 110 facing the dispersed phase channel 150 includes an inclined surface 112 and a stop surface 113. The stop surface 113 is connected between the inclined surface 112 and the front side wall of the sample cavity 110, and the branch channel 141 is connected to the stop surface 113; along the tangential direction of the rotation direction, the inclined surface 112 is gradually arranged away from the dispersed phase channel 150.

[0053] In some embodiments, the base 100 has an oil filling channel 121. One end of the oil filling channel 121 is communicated with the air cavity 120, and the other end opens upward. This kind of setting enables the collecting oil to first enter the air cavity 120 and infiltrate the side wall of the air cavity 120. Even if the droplets enter the air cavity 120, they can slide into the droplet storage cavity 130 under the action of inertia. Before producing droplets, the rotating disk can be rotated first. Under the action of inertia, the collecting oil can be transferred to the droplet storage cavity 130 by means of the inclined right side wall.

[0054] The fueling channel 121 includes a horizontal portion and a vertical portion 1213. The horizontal portion includes a connecting portion 1211 and a turning portion 1212. The connecting portion 1211 is parallel to the width direction, and the turning portion 1212 is parallel to the length direction. Along the liquid flow direction, and the turning portion 1212 is located upstream of the connecting portion 1211. The turning portion 1212 communicates with the vertical portion 1213 to prevent the collected oil from flowing out of the fueling channel 121 during the production of liquid droplets. Further, along the tangential direction of the rotation direction, the turning portion 1212 is located upstream of the connecting portion 1211, that is, the turning portion 1212 is located behind the connecting portion 1211. During the counterclockwise rotation, the liquid flows from the turning portion 1212 to the connecting portion 1211 and enters the air chamber 120. Among them, the width direction is the front-back direction.

[0055] To simplify the pipeline layout, the transfer channel 140 includes two branch channels 141 extending along the length direction of the base 100 and a summary channel 142 extending along the width direction of the base 100. One ends of the two branch channels 141 communicate with the two sample chambers 110 respectively; the other ends are both communicated with the summary channel 142; one end of the dispersed phase channel 150 is communicated with the summary channel 142. The two branch channels 141 and the summary channel 142 are integrally U-shaped.

[0056] To improve the production efficiency of liquid droplets, the base 100 has a plurality of dispersed phase channels 150 arranged at intervals along the width direction of the base 100, and each dispersed phase channel 150 is communicated with the summary channel 142. The width of the air chamber 120 is greater than the overall width of the plurality of dispersed phase channels 150.

[0057] Since the base 100 is made of a non-rigid material, to ensure the structural stability of the liquid droplet storage chamber 130, in some embodiments, there is a support member 133 in the liquid droplet storage chamber 130. The support member 133 extends along the vertical direction and supports in the liquid droplet storage chamber 130, and abuts against the upper side wall and the lower side wall of the liquid droplet storage chamber 130. Among them, the support member 133 is a cylindrical structure to reduce the blockage during the dispersion of liquid droplets. There are a plurality of support members 133 in the liquid droplet storage chamber 130, and the plurality of support members 133 are arranged in a matrix in the liquid droplet storage chamber 130.

[0058] For easy observation, the base 100 is made of a transparent material. After the liquid droplets are collected in the liquid droplet storage chamber 130, a reaction occurs, and it can be observed through the base 100, improving the detection efficiency.

[0059] Combined with Figure 5 and Figure 6As shown, for ease of preparation, the base 100 includes a structural layer 101 and a bottom plate layer 102. Among them, the structural layer 101 has a sample groove 1011, a transfer groove 1012, a dispersion groove 1013, a first air groove 1014, a droplet storage groove 1015, and a refueling groove 1016. Among them, the bottom plate layer 102 covers the structural layer 101 to seal each groove to form a sample chamber 110, a transfer channel 140, a dispersed phase channel 150, an air chamber 120, a droplet storage chamber 130, and a refueling channel 121 respectively. In some embodiments, the bottom plate layer 102 has a second air groove 1021 and an outward expansion groove 1022. The second air groove 1021 and the first air groove 1014 enclose the air chamber 120, and the droplet storage groove 1015 and the outward expansion groove 1022 enclose an outward expansion portion 132.

[0060] To improve the positioning accuracy of the two, in some embodiments, a first positioning groove 1017 is provided on the side of the structural layer 101 facing the bottom plate layer 102, and a second positioning groove 1023 is provided on the side of the bottom plate layer 102 facing the structural layer 101. The openings of the first positioning groove 1017 and the second positioning groove 1023 face each other and have the same contour. During installation, by observing the transparent structural layer 101, the structural layer 101 and the bottom plate layer 102 can be relatively moved so that the contours of the first positioning groove 1017 and the second positioning groove 1023 are aligned. Among them, both the first positioning groove 1017 and the second positioning groove 1023 are cross grooves.

[0061] Obviously, the above-mentioned embodiments of the present invention are merely examples for clearly explaining the present invention, rather than limiting the implementation manners of the present invention. For those of ordinary skill in the art, various obvious changes, re-adjustments, and substitutions can be made without departing from the protection scope of the present invention. It is not necessary and impossible to enumerate all the implementation manners here. Any modifications, equivalent substitutions, and improvements made within the spirit and principle of the present invention shall be included in the protection scope of the claims of the present invention.

Claims

1. A centrifugal drive droplet generating device, characterized in that, Comprising: A base (100), within which there are a sample chamber (110), an air chamber (120), and a droplet storage chamber (130) that are arranged at intervals in the horizontal direction and are sequentially connected. The base (100) also has a sample inlet channel (111) that communicates with the sample chamber (110). There is a transfer channel (140) within the base (100) with one end communicating with the sample chamber (110). There is a dispersed phase channel (150) extending in the horizontal direction within the base (100). The outlet of the dispersed phase channel (150) communicates with the air chamber (120), and the inlet of the dispersed phase channel (150) communicates with the transfer channel (140). The droplet storage chamber (130) is flat and is used to hold collected oil. The inlet of the droplet storage chamber (130) is horizontally arranged and communicates with the air chamber (120), and the collected oil fills the droplet storage chamber (130) under capillary action. The inlet of the droplet storage chamber (130) faces the outlet of the dispersed phase channel (150).

2. The centrifugal drive droplet generating device according to claim 1, wherein The droplet storage chamber (130) includes a main body portion (131) and an outward expansion portion (132). The outward expansion portion (132) communicates with the main body portion (131) and is located at the inlet of the droplet storage chamber (130). In the vertical direction, the size of the outward expansion portion (132) is larger than that of the main body portion (131). And / or, there is a support member (133) within the droplet storage chamber (130). The support member (133) extends in the vertical direction and supports within the droplet storage chamber (130).

3. The centrifugal drive droplet generating device according to claim 1, wherein, There are two sample chambers (110). The two sample chambers (110) are connected to each other, and each sample chamber (110) corresponds to a sample inlet channel (111). One of the sample inlet channels (111) is used to add liquid, and the other sample inlet channel (111) is used for exhausting air. And / or, the sample inlet channel (111) is vertically arranged with an upward opening.

4. The centrifugal drive droplet generating device according to claim 3, wherein The transfer channel (140) includes two branch channels (141) extending along the length direction of the base (100) and a summary channel (142) extending along the width direction of the base (100). One end of each of the two branch channels (141) communicates with one of the two sample chambers (110), and the other ends of both are connected to the summary channel (142). One end of the dispersed phase channel (150) is connected to the summary channel (142).

5. The centrifugal drive droplet generating device according to claim 4, wherein, The base (100) has a number of the dispersed phase channels (150) arranged at intervals along the width direction of the base (100), and each of the dispersed phase channels (150) communicates with the summary channel (142).

6. The centrifugal drive droplet generation device according to claim 4, wherein, The side wall of the sample chamber (110) facing the dispersed phase channel (150) includes an inclined surface (112) and a stop surface (113). The stop surface (113) is connected between the inclined surface (112) and the front side wall of the sample chamber (110). The branch channel (141) is connected to the stop surface (113). Along the tangential direction of the rotation direction, the inclined surface (112) is arranged gradually away from the dispersed phase channel (150).

7. The centrifugal driving droplet generating device according to claim 1, wherein Along the liquid flow direction, the first upper end surface (151) at the upper side of the outlet of the dispersed phase channel (150) is inclined downward. Along the liquid flow direction, the first lower end surface (152) at the lower side of the outlet of the dispersed phase channel (150) is inclined upward. The first upper end surface (151) and the first lower end surface (152) form the left side wall of the air chamber (120). And / or, along the liquid flow direction, the second upper end surface (155) at the upper side of the inlet of the droplet storage chamber (130) is inclined downward. Along the liquid flow direction, the second lower end surface (156) at the lower side of the inlet of the droplet storage chamber (130) is inclined upward. The second upper end surface (155) and the second lower end surface (156) form the right side wall of the air chamber (120).

8. The centrifugal drive droplet generating device according to claim 7, characterized in that Along the liquid flow direction, the front end surface (153) at the outlet of the dispersed phase channel (150) is inclined backward, and the rear end surface (154) at the outlet of the dispersed phase channel (150) is inclined forward.

9. The centrifugal drive droplet generation device according to any one of claims 1-8, characterized in that, The base (100) has an oil filling channel (121). One end of the oil filling channel (121) communicates with the air chamber (120), and the other end opens upward.

10. The centrifugal drive droplet generating device according to claim 9, characterized in that, The oil filling channel (121) includes a horizontal portion and a vertical portion (1213). The horizontal portion includes a connecting portion (1211) and a turning portion (1212). The connecting portion (1211) is parallel to the width direction, and the turning portion (1212) is parallel to the length direction. Along the liquid flow direction, and the turning portion (1212) is located upstream of the connecting portion (1211), and the turning portion (1212) communicates with the vertical portion (1213).

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