Electrospray ion source control method and device for mass spectrometer

Abstract

The embodiment of the invention discloses an electrospray ion source control method and device for a mass spectrometer, electronic equipment and a storage medium, and the method comprises the steps: obtaining a current value in a capillary tube and a pressure value of a pneumatic valve, and calculating a current deviation value and a pressure deviation value based on the current value and the pressure value; starting a nozzle adjusting motor to clean a nozzle based on the relation between the current deviation value and a set current deviation threshold value, and adjusting the airflow direction based on the relation between the pressure deviation value and a set pressure deviation threshold value. According to the embodiment of the invention, the current value in the capillary tube and the pressure value of the pneumatic valve are acquired in real time to judge whether sediment is accumulated or the airflow nozzle is blocked, and the nozzle adjusting motor is started in time to clean the nozzle or adjust the airflow direction when abnormity occurs, so that the nozzle is prevented from being blocked and the ionization efficiency is prevented from being reduced; and the analysis precision of the mass spectrometer and the continuity of signals are improved.

Description

Technical Field

[0001] The present invention relates to the technical field of mass spectrometry analysis, and particularly to an electrospray ion source control method, device, electronic device and storage medium for a mass spectrometer. Background Art

[0002] Electrospray Ionization (ESI) is an ionization technique widely used in mass spectrometry analysis. Its core principle is that a liquid sample is ejected from a capillary under the action of a high voltage to form charged droplets, and then the droplets are gradually dissolved and evaporated under the action of an electric field and finally decomposed into charged ions, and the charged ions enter the mass spectrometer for analysis. Since the electrospray ionization technique can effectively perform mass spectrometry analysis on macromolecular samples such as biomolecules and polypeptides, and has the characteristics of high sensitivity and high resolution, it has become an important technical means in the fields of life science, environmental science, drug research, etc.

[0003] In the traditional electrospray ionization technique, the sample is injected from the upstream end of the capillary, and the sample liquid is ionized by the action of an electric field to form charged ions or droplets, which are ejected into the mass spectrometer. An air flow injection method is introduced into this process to prevent the residue of the solvent and the accumulation of pollutants. In order to maintain the stability of the ion current, the traditional method usually uses a fixed capillary position to optimize the ionization efficiency. However, this scheme has limitations in the application process. Especially during the long-term operation of high-load or complex samples, problems such as blockage of the air flow nozzle will occur, ultimately affecting the analysis accuracy of the mass spectrometer and the continuity of the signal. Summary of the Invention

[0004] To solve the problems existing in the prior art, one or more embodiments of this specification describe an electrospray ion source control method, device, electronic device and storage medium for a mass spectrometer.

[0005] According to a first aspect, there is provided an electrospray ion source control method for a mass spectrometer, the method comprising: Obtaining a current value in the capillary and a pressure value of a pneumatic valve, and calculating a current deviation value and a pressure deviation value based on the current value and the pressure value; Starting a nozzle adjustment motor to clean the nozzle based on the relationship between the current deviation value and a set current deviation threshold, and adjusting the air flow direction based on the relationship between the pressure deviation value and a set pressure deviation threshold.

[0006] Preferably, the method further comprises: determining an adjustment amount of the capillary based on a set first relational expression and a set current stability threshold, and adjusting the protrusion amount of the capillary based on the adjustment amount of the capillary, so that the current value corresponding to the adjusted protrusion amount of the capillary is equal to the current stability threshold.

[0007] Preferably, the first relational expression is: , where I represents the current value in the capillary, d represents the protrusion amount of the capillary, k is a constant, and r represents the sensitivity index of the current change with respect to the capillary position change.

[0008] Preferably, the method further includes: obtaining the capillary port pressure, calculating the current particle flow intensity based on the capillary port pressure, when the set particle flow intensity threshold is not equal to the current particle flow intensity, determining the adjustment amount of the gas flow rate based on the set second relational expression and the set particle flow intensity threshold, and adjusting the gas flow rate based on the adjustment amount of the gas flow rate so that the particle flow intensity corresponding to the adjusted gas flow rate is equal to the particle flow intensity threshold.

[0009] Preferably, the second relational expression is: , where represents the particle flow intensity, represents the gas flow rate, represents the capillary port pressure, K is a constant, are respectively the influence indices of the gas flow rate and the capillary port pressure on the ion flow intensity.

[0010] Preferably, the method further includes: obtaining the pollution signal detected by the pollution sensor, obtaining the pollutant concentration based on the pollution signal, and outputting an alarm signal when the pollutant concentration is greater than the set pollution critical value.

[0011] Preferably, the method further includes: if within the set calibration times threshold, the pollutant concentration calculated each time during collection exceeds the pollution critical value, and the error between the pollutant concentrations calculated each time is less than the set calibration error threshold, then output an alarm signal.

[0012] According to the second aspect, there is provided an electrospray ion source control device for a mass spectrometer, the device including: A sampling module, configured to obtain the current value in the capillary and the pressure value of the pneumatic valve, and calculate the current deviation value and the pressure deviation value based on the current value and the pressure value; An execution module, configured to start the nozzle adjustment motor to clean the nozzle based on the relationship between the current deviation value and the set current deviation threshold, and adjust the air flow direction based on the relationship between the pressure deviation value and the set pressure deviation threshold.

[0013] According to the third aspect, there is provided an electronic device, including a processor and a memory; The processor is connected to the memory; The memory is used to store executable program code; The processor runs a program corresponding to the executable program code by reading the executable program code stored in the memory, so as to execute the steps of the method provided in the first aspect or any possible implementation manner of the first aspect.

[0014] According to the fourth aspect, there is provided a computer-readable storage medium, on which a computer program is stored. Instructions are stored in the computer-readable storage medium. When the instructions are run on a computer or a processor, the computer or the processor is caused to execute the method provided in the first aspect or any possible implementation manner of the first aspect.

[0015] The beneficial effects of the present invention are as follows: 1. The method and device provided in the embodiments of this specification determine whether sediment accumulation or air flow nozzle blockage occurs by obtaining the current value in the capillary and the pressure value of the pneumatic valve in real time, and when an abnormality occurs, the nozzle adjustment motor is started in time to clean the nozzle or adjust the air flow direction, avoiding nozzle blockage and a decrease in ionization efficiency, and improving the analysis accuracy and signal continuity of the mass spectrometer; 2. The method and device provided in the embodiments of this specification adjust the position of the capillary in real time through the current value in the capillary to ensure the continuous and stable operation of the ion source, effectively improving the accuracy and reliability of mass spectrometry analysis; 3. The method and device provided in the embodiments of this specification adjust the protrusion amount and gas flow rate of the capillary by collecting the current value in the capillary and the capillary port pressure in real time, ensuring that the ion source operates in an optimal state, thereby improving the ionization efficiency and the stability of the ion current, and avoiding detection errors caused by fluctuations; 4. The method and device provided in the embodiments of this specification can detect the pollutant concentration in real time through a pollution sensor and trigger an alarm, which can give an early warning when the pollution level has not seriously affected the analysis, reduce the risk of sudden failures, and ensure the stable operation of the instrument. Description of the Drawings

[0016] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts.

[0017] Figure 1 is a schematic flowchart of a method for controlling an electrospray ion source for a mass spectrometer in a specific implementation of this specification; Figure 2 is a first execution schematic diagram of a method for controlling an electrospray ion source for a mass spectrometer in a specific implementation of this specification; Figure 3 It is the second execution schematic diagram of a method for controlling an electrospray ion source used in a mass spectrometer in the specific implementation of this specification; Figure 4 It is the third execution schematic diagram of a method for controlling an electrospray ion source used in a mass spectrometer in the specific implementation of this specification; Figure 5 It is the structural schematic diagram of a device for controlling an electrospray ion source used in a mass spectrometer in the specific implementation of this specification; Figure 6 It is the structural schematic diagram of an electronic device in the specific implementation of this specification. Specific implementation mode

[0018] Next, the technical solutions in the embodiments of the present application will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present application.

[0019] In the following introduction, the terms "first" and "second" are only for the purpose of description and cannot be understood as indicating or implying relative importance. The following introduction provides multiple embodiments of the present application. Different embodiments can be replaced or combined, so the present application can also be considered to include all possible combinations of the same and / or different embodiments described. Thus, if one embodiment includes features A, B, and C, and another embodiment includes features B and D, then the present application should also be considered to include embodiments containing all other possible combinations of A, B, C, and D, even though such embodiments may not be explicitly described in the following content.

[0020] The following description provides examples and does not limit the scope, applicability, or examples set forth in the claims. Changes can be made to the functions and arrangements of the described elements without departing from the scope of the content of the present application. Various processes or components can be appropriately omitted, substituted, or added in each example. For example, the described method can be executed in a different order from the described order, and various steps can be added, omitted, or combined. In addition, the features described in some examples can be combined into other examples.

[0021] Refer to Figure 1 , Figure 1 It is the flow schematic diagram of a method for controlling an electrospray ion source provided by an embodiment of the present application. In the embodiment of the present application, the method includes: S101. Obtain the current value in the capillary and the pressure value of the pneumatic valve, and calculate the current deviation value and the pressure deviation value based on the current value and the pressure value; S102. Start the nozzle adjustment motor to clean the nozzle based on the relationship between the current deviation value and the set current deviation threshold, and adjust the air flow direction based on the relationship between the pressure deviation value and the set pressure deviation threshold.

[0022] The execution subject of this application can be the PLC controller of the electrospray ionization device.

[0023] In the embodiments of this specification, refer to Figure 1 , Figure 2 , the capillary is electrically connected to the current detection circuit. The current detection circuit detects the current value in the capillary in real time, and compares the current value with the preset current value to obtain the current deviation value. Assuming the current value in the capillary is I and the preset current value is , the calculation formula for the current deviation value is , where represents the current deviation value. The current detection circuit sends the electrical signal representing the current deviation value to the PLC controller. The pressure detection circuit is electrically connected to the pneumatic valve. The pressure detection circuit detects the pressure value of the air flow at the pneumatic valve in real time, and compares the pressure value with the preset pressure value to obtain the pressure deviation value. Assuming the pressure value of the air flow at the pneumatic valve is P and the preset pressure value is , the calculation formula for the pressure deviation value is , where represents the pressure deviation value. The pressure detection circuit sends the electrical signal representing the pressure deviation value to the PLC controller. The operator will preset the current deviation threshold and the pressure deviation threshold in advance. After receiving the current deviation value and the pressure deviation value, the PLC controller will compare the current deviation value with the current deviation threshold. When the current deviation value is greater than the current deviation threshold, it indicates that there is sediment accumulation in the gas flow nozzle, and the resistance of the nozzle gas flow channel increases, resulting in an excessive current value in the capillary. At this time, the PLC controller starts the nozzle adjustment motor to clean the nozzle. When the pressure deviation value is greater than the pressure deviation threshold, it indicates that the gas flow nozzle is blocked. At this time, the PLC controller adjusts the gas flow direction. In this application, by obtaining the current value in the capillary and the pressure value of the pneumatic valve in real time to determine whether there is sediment accumulation or the gas flow nozzle is blocked, and starting the nozzle adjustment motor to clean the nozzle or adjusting the gas flow direction in time when an abnormality occurs, nozzle blockage and a decrease in ionization efficiency are avoided, and the analysis accuracy and signal continuity of the mass spectrometer are improved.

[0024] It should be noted that the current detection circuit includes a current acquisition resistor and an operational amplifier. The first end of the current acquisition resistor is electrically connected to the first end of the capillary tube. The second end of the current acquisition resistor is connected to the voltage input. The second end of the capillary tube is grounded. The first input terminal of the operational amplifier is electrically connected to the first end of the current acquisition resistor. The second input terminal of the operational amplifier is electrically connected to the second end of the current acquisition resistor. The output terminal of the operational amplifier is electrically connected to the PLC controller. The pressure detection circuit includes a voltage-dividing resistor, a varistor, and a comparator. The first interface of the comparator is connected to the voltage input of the preset pressure value. The second interface of the comparator is electrically connected to the first end of the voltage-dividing resistor and the first end of the varistor. The second end of the voltage-dividing resistor is connected to the voltage input. The second end of the varistor is grounded. The third interface of the comparator is electrically connected to the PLC controller.

[0025] In an implementable embodiment, refer to Figure 3 to establish a first relationship between the current value in the capillary tube and the protrusion amount of the capillary tube, and set a current stability threshold. When the current value in the capillary tube detected by the current detection circuit is not equal to the current stability threshold, the PLC controller controls the mechanical component to adjust the protrusion amount of the capillary tube according to the first relationship, so that the current value in the capillary tube corresponding to the adjusted protrusion amount of the capillary tube is equal to the current stability threshold. For example, set the current stability threshold to 150 mA and the initial protrusion amount to 1 mm. When the current rises to 600 mA, the PLC controller adjusts the position of the capillary tube to reduce the protrusion amount so that the current returns to 150 mA. By adjusting the position of the capillary tube in real time according to the current value in the capillary tube, the continuous and stable operation of the ion source is ensured, and the accuracy and reliability of mass spectrometry analysis are effectively improved.

[0026] Specifically, the first relationship is: , where I represents the current value in the capillary tube, d represents the protrusion amount of the capillary tube, k is a constant, and r represents the sensitivity index of the current change with respect to the change in the position of the capillary tube.

[0027] In an implementable embodiment, a second relationship between the gas flow rate and the capillary port pressure is established. The PLC controller obtains the capillary port pressure and the gas flow rate, calculates the current particle flow intensity based on the capillary port pressure and the gas flow rate, sets a particle flow intensity threshold. When the particle flow intensity threshold is not equal to the current particle flow intensity, the PLC controller changes the gas flow rate so that the particle flow intensity corresponding to the changed gas flow rate is equal to the particle flow intensity threshold. Specifically, the gas flow rate can be changed by changing the opening of the pneumatic valve, and the gas flow direction can be changed by changing the opening direction of the pneumatic valve. In this application, by collecting the current value in the capillary tube and the capillary port pressure in real time to adjust the protrusion amount of the capillary tube and the gas flow rate, it is ensured that the ion source operates in an optimal state, thereby improving the ionization efficiency and the stability of the ion flow, and avoiding detection errors caused by fluctuations.

[0028] Specifically, the second relational expression is: , where represents the particle flow intensity, represents the gas flow rate, represents the capillary port pressure, and K is a constant. are respectively the influence indices of the gas flow rate and the capillary port pressure on the ion flow intensity.

[0029] In an implementable embodiment, referring to Figure 4 , the pollution sensor is arranged inside the air flow protection cover. The pollution sensor is used to detect the pollutant concentration inside the device. The PLC controller calculates the pollutant concentration according to the pollution signal transmitted by the pollution sensor. When the pollutant concentration exceeds the preset pollution critical value, an alarm is triggered. The process of calculating the pollutant concentration through the pollution sensor is C = S * G, where C represents the pollutant concentration, S is the pollution signal output by the pollution sensor, and G is the sensitivity coefficient of the pollution sensor. By detecting the pollutant concentration in real time through the pollution sensor and triggering an alarm, it is possible to give an early warning when the pollution level has not seriously affected the analysis, reduce the risk of sudden failures, and ensure the stable operation of the instrument.

[0030] Furthermore, a calibration times threshold and a calibration error threshold are set. If within the calibration times threshold, the pollutant concentration calculated each time during acquisition exceeds the pollution critical value, and the error between the pollutant concentrations calculated each time is less than the calibration error threshold, then an alarm signal is output. By setting the calibration times threshold and the calibration error threshold, false alarms of the system are avoided, the accuracy of the alarm is improved, and false alarms caused by changes in the sensitivity of the pollution sensor during long-term use are avoided. For example, if the calibration times threshold is set to 3 times and the calibration error threshold is set to 2%, if the pollutant concentration calculated through acquisition exceeds the pollution critical value three times in a row and the error between each time is less than 2%, the PLC controller will directly give an alarm prompt for maintenance.

[0031] Next, in combination with the attached Figure 5 , the electrospray ion source control device for a mass spectrometer provided by the embodiments of the present application will be introduced in detail. It should be noted that the electrospray ion source control device for a mass spectrometer shown in the attached Figure 5 is used to execute the method of the embodiments of the present application shown in Figure 1 . For the sake of convenience of description, only the parts related to the embodiments of the present application are shown. For the specific technical details not disclosed, please refer to the embodiments of the present application shown in Figure 1 .

[0032] Please refer to Figure 5 , Figure 5 which is a schematic structural diagram of the electrospray ion source control device for a mass spectrometer provided by the embodiments of the present application. As shown in Figure 5 , the device includes: Sampling module 201 is used to obtain the current value in the capillary and the pressure value of the pneumatic valve, and calculate the current deviation value and the pressure deviation value based on the current value and the pressure value; Execution module 202 is used to start the nozzle adjustment motor to clean the nozzle based on the relationship between the current deviation value and the set current deviation threshold, and adjust the air flow direction based on the relationship between the pressure deviation value and the set pressure deviation threshold.

[0033] In an implementable manner, the execution module 202 is specifically used for: The method further includes: determining the adjustment amount of the capillary based on the set first relational expression and the set current stability threshold, and adjusting the protrusion amount of the capillary based on the adjustment amount of the capillary, so that the current value corresponding to the adjusted protrusion amount of the capillary is equal to the current stability threshold.

[0034] In an implementable manner, the execution module 202 is specifically used for: The first relational expression is: , where I represents the current value in the capillary, d represents the protrusion amount of the capillary, k is a constant, and r represents the sensitivity index of the current change with respect to the capillary position change.

[0035] In an implementable manner, the execution module 202 is specifically used for: Obtain the capillary port pressure, calculate the current particle flow intensity based on the capillary port pressure, and when the set particle flow intensity threshold is not equal to the current particle flow intensity, determine the adjustment amount of the gas flow rate based on the set second relational expression and the set particle flow intensity threshold, and adjust the gas flow rate based on the adjustment amount of the gas flow rate, so that the particle flow intensity corresponding to the adjusted gas flow rate is equal to the particle flow intensity threshold.

[0036] In an implementable manner, the execution module 202 is specifically used for: The second relational expression is: , where represents the particle flow intensity, represents the gas flow rate, represents the capillary port pressure, K is a constant, are respectively the influence indices of the gas flow rate and the capillary port pressure on the ion flow intensity.

[0037] In an implementable manner, the execution module 202 is specifically used for: Obtain the pollution signal detected by the pollution sensor, obtain the pollutant concentration based on the pollution signal, and output an alarm signal when the pollutant concentration is greater than the set pollution critical value.

[0038] In one implementable manner, the execution module 202 is specifically configured to: If, within the set calibration times threshold, the pollutant concentration calculated each time exceeds the pollution critical value, and the error between the pollutant concentrations calculated each time is less than the set calibration error threshold, an alarm signal is output.

[0039] Those skilled in the art can clearly understand that the technical solutions of the embodiments of the present application can be implemented by means of software and / or hardware. The "units" and "modules" in this specification refer to software and / or hardware that can independently complete or cooperate with other components to complete specific functions, where the hardware can be, for example, a Field-Programmable Gate Array (FPGA), an Integrated Circuit (IC), etc.

[0040] Each processing unit and / or module of the embodiments of the present application can be implemented by an analog circuit that implements the functions described in the embodiments of the present application, or can be implemented by software that executes the functions described in the embodiments of the present application.

[0041] Refer to Figure 6 , which shows a schematic structural diagram of an electronic device involved in the embodiments of the present application. This electronic device can be used to implement Figure 1 the method in the illustrated embodiment. As Figure 6 shown, the electronic device 300 may include: at least one central processing unit 301, at least one network interface 304, a user interface 303, a memory 305, and at least one communication bus 302.

[0042] Among them, the communication bus 302 is used to realize the connection and communication between these components.

[0043] Among them, the user interface 303 may include a display screen (Display) and a camera (Camera). Optionally, the user interface 303 may further include a standard wired interface and a wireless interface.

[0044] Among them, the network interface 304 may optionally include a standard wired interface and a wireless interface (such as a WI-FI interface).

[0045] Among them, the central processing unit 301 may include one or more processing cores. The central processing unit 301 connects various parts within the entire electronic device 300 through various interfaces and circuits, and executes various functions of the terminal 300 and processes data by running or executing instructions, programs, code sets, or instruction sets stored in the memory 305, and by calling the data stored in the memory 305. Optionally, the central processing unit 301 may be implemented in at least one hardware form of digital signal processing (DSP), field-programmable gate array (FPGA), or programmable logic array (PLA). The central processing unit 301 may integrate a combination of one or more of a central processing unit (CPU), a graphics processing unit (GPU), and a modem, etc. Among them, the CPU mainly processes the operating system, user interface, application programs, etc.; the GPU is responsible for rendering and drawing the content to be displayed on the display screen; the modem is used to process wireless communication. It can be understood that the above-mentioned modem may not be integrated into the central processing unit 301 and may be implemented separately by a chip.

[0046] Among them, the memory 305 may include random access memory (RAM) and may also include read-only memory. Optionally, the memory 305 includes a non-transitory computer-readable storage medium. The memory 305 can be used to store instructions, programs, code, code sets, or instruction sets. The memory 305 may include a program storage area and a data storage area. Among them, the program storage area may store instructions for implementing the operating system, instructions for at least one function (such as touch function, sound playback function, image playback function, etc.), instructions for implementing the above-mentioned method embodiments, etc.; the data storage area may store the data involved in the above-mentioned method embodiments. Optionally, the memory 305 may further be at least one storage device located far from the aforementioned central processing unit 301. As Figure 6 shown, the memory 305, as a computer storage medium, may include an operating system, a network communication module, a user interface module, and program instructions.

[0047] In Figure 6In the electronic device 300 shown, the user interface 303 is mainly used to provide an interface for the user to input data and obtain the data input by the user; while the central processing unit 301 can be used to call the application programs stored in the memory 305 and specifically perform the following operations: S101. Obtain the current value in the capillary and the pressure value of the pneumatic valve, and calculate the current deviation value and the pressure deviation value based on the current value and the pressure value; S102. Start the nozzle adjustment motor to clean the nozzle based on the relationship between the current deviation value and the set current deviation threshold, and adjust the air flow direction based on the relationship between the pressure deviation value and the set pressure deviation threshold.

[0048] The present application also provides a computer-readable storage medium, on which a computer program is stored, and when the program is executed by a processor, the steps of the above method are implemented. Among them, the computer-readable storage medium may include, but is not limited to, any type of disk, including floppy disks, optical disks, DVDs, CD-ROMs, micro drives, and magneto-optical disks, ROMs, RAMs, EPROMs, EEPROMs, DRAMs, VRAMs, flash memory devices, magnetic cards or optical cards, nano-systems (including molecular memory ICs), or any type of medium or device suitable for storing instructions and / or data.

[0049] It should be noted that, for the foregoing method embodiments, for the sake of simple description, they are all expressed as a series of action combinations. However, those skilled in the art should know that the present application is not limited by the described action sequence, because according to the present application, certain steps can be performed in other sequences or simultaneously. Secondly, those skilled in the art should also know that the embodiments described in the specification are all preferred embodiments, and the actions and modules involved are not necessarily essential to the present application.

[0050] In the above embodiments, the descriptions of the respective embodiments have their own emphases. For the parts not detailed in a certain embodiment, reference can be made to the relevant descriptions of other embodiments.

[0051] In several embodiments provided by the present application, it should be understood that the disclosed device can be implemented in other ways. For example, the device embodiments described above are only illustrative. For example, the division of the units is only a logical function division. In actual implementation, there may be other division methods. For example, multiple units or components can be combined or integrated into another system, or some features can be ignored or not executed. Another point is that the displayed or discussed mutual coupling or direct coupling or communication connection can be through some service interfaces, and the indirect coupling or communication connection of the device or unit can be in an electrical or other form.

[0052] The unit described as a separation component may or may not be physically separated. The component shown as a unit may or may not be a physical unit, that is, it may be located in one place or distributed to multiple network units. Some or all of the units can be selected according to actual needs to achieve the purpose of the solution of this embodiment.

[0053] In addition, each functional unit in various embodiments of the present application may be integrated in a processing unit, or each unit may exist physically alone, or two or more units may be integrated in one unit. The above-mentioned integrated unit may be implemented in the form of hardware or in the form of a software functional unit.

[0054] If the integrated unit is implemented in the form of a software functional unit and sold or used as an independent product, it can be stored in a computer-readable memory. Based on such an understanding, the technical solution of the present application, in essence, or the part that contributes to the prior art, or all or part of this technical solution, can be embodied in the form of a software product. This computer software product is stored in a memory and includes several instructions for causing a computer device (which may be a personal computer, a server, or a network device, etc.) to execute all or part of the steps of the methods described in various embodiments of the present application. The aforementioned memory includes: USB flash drives, read-only memory (ROM), random access memory (RAM), mobile hard disks, magnetic disks, or optical discs, etc., which can store program codes.

[0055] Those of ordinary skill in the art can understand that all or part of the steps in the various methods of the above embodiments can be completed by instructing relevant hardware through a program. This program can be stored in a computer-readable memory. The memory may include: flash drives, read-only memory (ROM), random access memory (RAM), magnetic disks, or optical discs, etc.

[0056] The above are only exemplary embodiments of the present disclosure, and the scope of the present disclosure cannot be limited thereby. That is, any equivalent changes and modifications made in accordance with the teachings of the present disclosure still fall within the scope covered by the present disclosure. After considering the specification and practicing the present disclosure, those skilled in the art will easily think of other implementation manners of the present disclosure. The present application aims to cover any variations, uses, or adaptive changes of the present disclosure, and these variations, uses, or adaptive changes follow the general principles of the present disclosure and include the common general knowledge or conventional technical means in the technical field not recorded in the present disclosure. The specification and the embodiments are only regarded as exemplary, and the scope and spirit of the present disclosure are defined by the claims.

Claims

1. A method for controlling an electrospray ion source for a mass spectrometer, characterized in that, The method includes: Obtaining the current value in the capillary and the pressure value of the pneumatic valve, and calculating a current deviation value and a pressure deviation value based on the current value and the pressure value; Starting a nozzle adjustment motor to clean the nozzle based on the relationship between the current deviation value and a set current deviation threshold, and adjusting the air flow direction based on the relationship between the pressure deviation value and a set pressure deviation threshold.

2. The electrospray ionization source control method for a mass spectrometer according to claim 1, wherein The method further includes: determining an adjustment amount of the capillary based on a set first relational expression and a set current stability threshold, and adjusting the protruding amount of the capillary based on the adjustment amount of the capillary, so that the current value corresponding to the adjusted protruding amount of the capillary is equal to the current stability threshold.

3. A method for controlling an electrospray ion source for a mass spectrometer according to claim 2, characterized in that, The first relational expression is as follows: , where I represents the current value in the capillary, d represents the protrusion amount of the capillary, k is a constant, and r represents the sensitivity index of the current change with respect to the capillary position change.

4. A method for controlling an electrospray ion source for a mass spectrometer according to claim 2, characterized in that, The method further includes: obtaining the capillary port pressure, calculating a current particle flow intensity based on the capillary port pressure, and when a set particle flow intensity threshold is not equal to the current particle flow intensity, determining an adjustment amount of the gas flow rate based on a set second relational expression and the set particle flow intensity threshold, and adjusting the gas flow rate based on the adjustment amount of the gas flow rate, so that the particle flow intensity corresponding to the adjusted gas flow rate is equal to the particle flow intensity threshold.

5. A method for controlling an electrospray ion source for a mass spectrometer according to claim 4, characterized in that, The second relational expression is as follows: , where represents the particle flow intensity, represents the gas flow rate, represents the capillary port pressure, and K is a constant, are respectively the influence indices of the gas flow rate and the capillary port pressure on the ion flow intensity.

6. A method for controlling an electrospray ion source for a mass spectrometer according to claim 1, characterized in that, The method further includes: obtaining a pollution signal detected by a pollution sensor, obtaining a pollutant concentration based on the pollution signal, and outputting an alarm signal when the pollutant concentration is greater than a set pollution critical value.

7. A method for controlling an electrospray ion source for a mass spectrometer according to claim 6, characterized in that, The method further includes: if within a set calibration times threshold, the pollutant concentration calculated each time during acquisition exceeds the pollution critical value, and the error between the pollutant concentrations calculated each time is less than a set calibration error threshold, then outputting an alarm signal.

8. An electrospray ion source control device for a mass spectrometer, characterized in that, The device includes: A sampling module, configured to obtain the current value in the capillary and the pressure value of the pneumatic valve, and calculate a current deviation value and a pressure deviation value based on the current value and the pressure value; An execution module, configured to start a nozzle adjustment motor to clean the nozzle based on the relationship between the current deviation value and a set current deviation threshold, and adjust the air flow direction based on the relationship between the pressure deviation value and a set pressure deviation threshold.

9. An electronic device, comprising a memory, a processor, and a computer program stored on the memory and executable on the processor, characterized in that, When the processor executes the computer program, the steps of the method according to any one of claims 1-7 are implemented.

10. A computer-readable storage medium, on which a computer program is stored, and instructions are stored in the computer-readable storage medium. When the instructions run on a computer or a processor, the computer or the processor is caused to execute the steps of the method according to any one of claims 1-7.

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