Concentration device and method for diabetes medicine production

Abstract

The invention relates to the technical field of medicine production, in particular to a concentration device and method for diabetes medicine production, and the method comprises the following steps: obtaining medicinal raw materials, and pretreating the medicinal raw materials to obtain a medicinal extracting solution; performing low-temperature concentration on the medicinal material extracting solution through a stirring concentration tank to obtain a medicinal material concentrated solution; discharging the medicinal material concentrated solution, and performing subsequent processing to prepare the diabetes medicine, and meanwhile, cleaning the stirring concentration tank. According to the method, in the medicine concentration process, the evaporation degree of water is reduced by reducing the pressure of the stirring concentration tank, and the extracting solution is continuously stirred in the concentration process, so that local overheating is avoided; and the stirring concentration tank is strongly cleaned based on an ultrasonic cleaning technology, so that concentrated solution residues are avoided, cross infection during subsequent concentration is avoided, the concentration quality of the diabetes medicine is improved, and safer, more effective and more economical treatment medicine is provided for diabetics.

Description

Technical Field

[0001] The present invention relates to the technical field of drug production, and particularly to a concentration device and method for producing diabetes drugs. Background Art

[0002] Diabetes is a global chronic disease, and its incidence rate is increasing year by year, posing a serious threat to human health. In the treatment of diabetes, drug treatment is an indispensable part. However, in the production process of diabetes drugs, the concentration link is a crucial step, which directly affects the purity and stability of the drugs, and further affects the efficacy and safety of the drugs.

[0003] There are many deficiencies in the traditional concentration methods for producing diabetes drugs. For example, local overheating is likely to occur during the concentration process, resulting in the destruction of drug components and a reduction in the purity of the drugs; at the same time, it is difficult to thoroughly clean after concentration, which is prone to cross-contamination and affects the quality of drugs in subsequent batches.

[0004] Therefore, there is an urgent need for a concentration device and method for producing diabetes drugs to solve the problems of poor drug quality caused by local overheating and cross-infection during the above-mentioned concentration process. Summary of the Invention

[0005] The purpose of the present invention is to provide a concentration device and method for producing diabetes drugs, aiming to solve the problem of poor drug quality caused by local overheating and cross-infection in the traditional concentration method for producing diabetes drugs.

[0006] To achieve the above purpose, in the first aspect, the present invention provides a concentration method for producing diabetes drugs, including the following steps:

[0007] Obtain medicinal material raw materials, and perform pretreatment on the medicinal material raw materials to obtain a medicinal material extract;

[0008] Perform low-temperature concentration on the medicinal material extract through a stirring concentration tank to obtain a medicinal material concentrate;

[0009] Discharge the medicinal material concentrate for subsequent processing to prepare diabetes drugs, and at the same time, clean the stirring concentration tank.

[0010] Among them, the specific method for obtaining medicinal material raw materials and performing pretreatment on the medicinal material raw materials to obtain a medicinal material extract:

[0011] Obtain medicinal material raw materials, and successively perform cleaning, drying, crushing, and screening on the medicinal material raw materials to obtain medicinal material residues;

[0012] Introduce the medicinal material residues into an extraction tank, and extract the medicinal material residues based on the water extraction method to obtain a crude extract;

[0013] Discharge the crude extract into a filtering device to filter out the medicinal residues therein, obtaining a medicinal material extract.

[0014] Among them, the medicinal material raw materials include gypsum, anemarrhena rhizome, rehmannia root, ophiopogon root, trichosanthes root, polygonatum rhizome, scrophularia root, achyranthes root, salvia root, alisma rhizome, codonopsis root, cornel fruit, eriobotrya leaf, and kadsura fruit.

[0015] Among them, the specific method of performing low-temperature concentration on the medicinal material extract by the stirring and concentration tank to obtain a concentrated medicinal material solution:

[0016] Introduce the medicinal material extract into the stirring and concentration tank, and preset the concentration condition parameters of the stirring and concentration tank;

[0017] Perform low-temperature concentration on the medicinal material extract based on the concentration condition parameters to obtain a concentrated solution;

[0018] Detect the concentration of the concentrated solution in real time, and stop until the detected concentration meets the requirements, obtaining a concentrated medicinal material solution.

[0019] Among them, the specific method of discharging the concentrated medicinal material solution for subsequent processing to prepare diabetes drugs, and at the same time, cleaning the stirring and concentration tank:

[0020] Discharge the concentrated medicinal material solution for subsequent processing to prepare diabetes drugs;

[0021] Perform quality inspection on the diabetes drugs, and package the qualified diabetes drugs;

[0022] Introduce hot water into the stirring and concentration tank for soaking for 1 - 2 hours, and use ultrasonic cleaning technology to clean the stirring and concentration tank after soaking.

[0023] In a second aspect, the present invention also provides a concentration device for producing diabetes drugs, which is applied to the concentration method for producing diabetes drugs as described in the first aspect above; it includes a concentration tank, a control module, a pressure module, a heating module, a detection module, and a cleaning module. The concentration tank is respectively connected to the control module, the pressure module, the heating module, the detection module, and the cleaning module, and the control module is respectively connected to the concentration tank, the pressure module, the heating module, the detection module, and the cleaning module;

[0024] The concentration tank performs low-temperature concentration on the medicinal material extract therein based on the concentration condition parameters to obtain a concentrated medicinal material solution;

[0025] The control module is used to control the concentration tank to perform low-temperature concentration on the medicinal material extract and preset the concentration condition parameters;

[0026] The air pressure module is used to adjust the air pressure of the concentration tank;

[0027] The heating module is used to heat the medicinal material extract in the concentration tank;

[0028] The detection module is used to detect the medicinal material concentrated solution in the concentration tank in real time;

[0029] The cleaning module is used to clean the concentration tank after the medicinal material extract is discharged to remove the remaining medicinal material extract.

[0030] Wherein, the cleaning module includes a water delivery unit, a liquid level unit and a cleaning unit;

[0031] The water delivery unit is used to introduce clean water into the concentration tank;

[0032] The liquid level unit is used to detect the liquid level of the clean water in the concentration tank and send a control signal to the control module;

[0033] The cleaning unit cleans the mixing concentration tank based on ultrasonic cleaning technology.

[0034] A concentration method for producing diabetes drugs according to the present invention includes obtaining raw medicinal materials, preprocessing the raw medicinal materials to obtain a medicinal material extract; performing low-temperature concentration on the medicinal material extract through a stirring concentration tank to obtain a medicinal material concentrated solution; discharging the medicinal material concentrated solution for subsequent processing to prepare diabetes drugs, and at the same time, cleaning the stirring concentration tank. During the drug concentration process, by reducing the pressure of the stirring concentration tank, the evaporation degree of water is reduced, and the extract is continuously stirred during the concentration process, effectively avoiding the phenomenon of local overheating and damage to drug components. And based on ultrasonic cleaning technology, the stirring concentration tank is powerfully cleaned to avoid the residue of the concentrated solution, effectively avoiding cross-infection during subsequent concentration, greatly improving the quality of diabetes drug concentration, providing safer, effective and economical therapeutic drugs for diabetes patients, and solving the problem of poor drug quality caused by local overheating and cross-infection during the concentration process of traditional diabetes drug production concentration methods. Description of the Drawings

[0035] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the following drawings are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.

[0036] Figure 1It is a flowchart of a concentration method for the production of diabetes drugs provided by the present invention.

[0037] Figure 2 It is a flowchart of a specific method for obtaining medicinal material raw materials and preprocessing the medicinal material raw materials to obtain a medicinal material extract.

[0038] Figure 3 It is a flowchart of a specific method for low-temperature concentrating the medicinal material extract by a stirring concentration tank to obtain a medicinal material concentrate.

[0039] Figure 4 It is a flowchart of a specific method for discharging the medicinal material concentrate for subsequent processing to prepare diabetes drugs, and at the same time, cleaning the stirring concentration tank.

[0040] Figure 5 It is a connection schematic diagram of a concentration device for the production of diabetes drugs provided by the present invention.

[0041] In the figure: 1 - concentration tank, 2 - control module, 3 - air pressure module, 4 - heating module, 5 - detection module, 6 - cleaning module, 7 - water delivery unit, 8 - liquid level unit, 9 - cleaning unit. Detailed implementation manners

[0042] The embodiments of the present invention will be described in detail below. The examples of the embodiments are shown in the accompanying drawings, where the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below by referring to the accompanying drawings are exemplary and are intended to explain the present invention and should not be construed as limiting the present invention.

[0043] Please refer to Figures 1 to 4 , in the first aspect, the present invention provides a concentration method for the production of diabetes drugs, including the following steps:

[0044] S1 Obtain medicinal material raw materials and preprocess the medicinal material raw materials to obtain a medicinal material extract;

[0045] Specific method:

[0046] S11 Obtain medicinal material raw materials and sequentially perform cleaning, drying, crushing, and screening on the medicinal material raw materials to obtain medicinal material residues;

[0047] In the embodiments of the present invention, the medicinal material raw materials include gypsum, anemarrhena rhizome, rehmannia root, ophiopogon root, trichosanthes root, polygonatum rhizome, scrophularia root, achyranthes root, salvia root, alisma rhizome, codonopsis root, cornel fruit, loquat leaf, and schisandra chinensis. The purpose of cleaning the above-mentioned medicinal materials is to remove the dust and impurities on the medicinal materials, which is convenient for the crusher to crush the medicinal materials after drying. The purpose of crushing and screening is to improve the concentration efficiency of the components of the subsequent medicinal materials.

[0048] S12 Introduce the medicinal residue into the extraction tank and extract the medicinal residue based on the water extraction method to obtain a crude extract.

[0049] In the embodiment of the present invention, through water extraction, the interaction force between water molecules and soluble components in the medicinal residue is utilized, and by heating, the active ingredients in the medicinal materials are dissolved in water to obtain a crude extract.

[0050] S13 Drain the crude extract into a filtering device to filter out the medicinal residues therein, obtaining a medicinal extract.

[0051] In the embodiment of the present invention, the medicinal residues in the crude extract are filtered out by a filtering device to avoid the influence of the medicinal residues on the subsequent concentration quality and the quality of diabetes drugs.

[0052] S2 Concentrate the medicinal extract at a low temperature through a stirring concentration tank to obtain a concentrated medicinal extract.

[0053] Specific method:

[0054] S21 Introduce the medicinal extract into the stirring concentration tank and preset the concentration condition parameters of the stirring concentration tank.

[0055] In the embodiment of the present invention, the concentration condition parameters include concentration pressure, concentration temperature, concentration time, concentration, volume of the concentrated liquid, etc., providing a basis for the subsequent concentration of the medicinal extract.

[0056] S22 Concentrate the medicinal extract at a low temperature based on the concentration condition parameters to obtain a concentrated liquid.

[0057] In the embodiment of the present invention, based on the concentration condition parameters, a vacuum pump is turned on to reduce the pressure in the stirring concentration tank. Under reduced pressure conditions, the boiling point of water decreases, and the medicinal extract is heated (60 °C), thereby achieving low-temperature concentration.

[0058] S23 Detect the concentration of the concentrated liquid in real time until the detected concentration reaches the requirement and then stop to obtain a concentrated medicinal extract.

[0059] S3 Drain the concentrated medicinal extract for subsequent processing to prepare diabetes drugs. At the same time, clean the stirring concentration tank.

[0060] Specific method:

[0061] S31 Drain the concentrated medicinal extract for subsequent processing to prepare diabetes drugs.

[0062] S32 Conduct quality inspection on the diabetes drugs and package the qualified diabetes drugs.

[0063] S33 imports hot water into the mixing and concentration tank for soaking for 1 - 2 hours, and after soaking, uses ultrasonic cleaning technology to clean the mixing and concentration tank.

[0064] Please refer to Figure 5 , In a second aspect, the present invention also provides a concentration device for the production of diabetes drugs, which is applied to the concentration method for the production of diabetes drugs as described in the first aspect above; it includes a concentration tank 1, a control module 2, a pressure module 3, a heating module 4, a detection module 5, and a cleaning module 6. The concentration tank 1 is respectively connected to the control module 2, the pressure module 3, the heating module 4, the detection module 5, and the cleaning module 6, and the control module 2 is respectively connected to the concentration tank 1, the pressure module 3, the heating module 4, the detection module 5, and the cleaning module 6;

[0065] The concentration tank 1 performs low - temperature concentration on the medicinal material extract therein based on the concentration condition parameters to obtain a concentrated medicinal material solution;

[0066] The control module 2 is used to control the concentration tank 1 to perform low - temperature concentration on the medicinal material extract and preset the concentration condition parameters;

[0067] The pressure module 3 is used to adjust the air pressure of the concentration tank 1;

[0068] The heating module 4 is used to heat the medicinal material extract in the concentration tank 1;

[0069] The detection module 5 is used to detect the concentrated medicinal material solution in the concentration tank 1 in real - time;

[0070] The cleaning module 6 is used to clean the concentration tank 1 after the medicinal material extract is discharged to remove the remaining medicinal material extract.

[0071] In an embodiment of the present invention, the control module 2 preset the concentration condition parameters and control the operation of the air pressure module 3, the heating module 4, the detection module 5 and the cleaning module 6. The air pressure module 3 is turned on to reduce the air pressure in the concentration tank 1, and the heating module 4 operates to heat the extraction liquid in the concentration tank 1, so as to realize the low-temperature concentration of the extraction liquid. During the concentration of the extraction liquid in the concentration tank 1, the detection module 5 is used to detect the medicinal material concentrated liquid in the concentration tank 1 in real time. After the detected concentration reaches the requirement, the concentration is stopped. At this time, the liquid discharge port of the concentration tank 1 discharges for subsequent processing. After the concentrated liquid is drained, the cleaning module 6 imports cleaning water into the concentration tank 1 for soaking. During the soaking process, the heating module 4 continuously heats to keep the temperature of the soaking water consistent with that of the concentrated liquid. After soaking for 1-2 hours, the cleaning module 6 cleans the inner wall of the concentration tank 1 based on ultrasonic cleaning technology and discharges the waste water, so as to avoid the phenomenon of cross-infection in the subsequent concentration process caused by the residual concentrated liquid in the concentration tank 1.

[0072] Further, the cleaning module 6 includes a water delivery unit 7, a liquid level unit 8 and a cleaning unit 9;

[0073] The water delivery unit 7 is used to import cleaning water into the concentration tank 1;

[0074] The liquid level unit 8 is used to detect the liquid level of the cleaning water in the concentration tank 1 and send a control signal to the control module 2;

[0075] The cleaning unit 9 cleans the mixing concentration tank 1 based on ultrasonic cleaning technology.

[0076] In an embodiment of the present invention, the water delivery unit 7 imports cleaning water into the concentration tank 1; the liquid level unit 8 is used for the water supply chamber of the water delivery unit 7 to detect the liquid level of the cleaning water in the concentration tank 1. When the water level reaches the appropriate position, a control signal is sent to the control module 2, and the control module 2 controls the water delivery unit 7 to stop. After the concentration tank is soaked for 1-2 hours, the cleaning unit 9 cleans the mixing concentration tank 1 based on ultrasonic cleaning technology, so as to avoid the phenomenon of cross-infection in the subsequent concentration process caused by the residual concentrated liquid in the concentration tank 1.

[0077] The above-disclosed is only a preferred embodiment of a concentration device and method for producing diabetes drugs according to the present invention. Of course, the scope of the rights of the present invention cannot be limited by this. Those of ordinary skill in the art can understand all or part of the processes of the above embodiments, and the equivalent changes made according to the claims of the present invention still fall within the scope covered by the present invention.

Claims

1. A concentration method for the production of diabetes drugs, characterized in that, It includes the following steps: Obtain medicinal material raw materials, and pre-treat the medicinal material raw materials to obtain a medicinal material extract; Perform low-temperature concentration on the medicinal material extract through a stirring and concentration tank to obtain a concentrated medicinal material solution; Discharge the concentrated medicinal material solution for subsequent processing to prepare diabetes drugs. At the same time, clean the stirring and concentration tank.

2. The concentration method for the production of diabetes drugs according to claim 1, It is characterized in that; The specific method for obtaining medicinal material raw materials and pre-treating the medicinal material raw materials to obtain a medicinal material extract: Obtain medicinal material raw materials, and successively perform cleaning, drying, crushing, and screening on the medicinal material raw materials to obtain medicinal material residues; Introduce the medicinal material residues into an extraction tank, and extract the medicinal material residues based on the water extraction method to obtain a crude extract; Discharge the crude extract into a filtering device to filter out the medicinal residues therein to obtain a medicinal material extract.

3. The concentration method for the production of diabetes drugs as described in claim 1, It is characterized in that; The medicinal material raw materials include gypsum, anemarrhena rhizome, rehmannia root, ophiopogon root, trichosanthes root, polygonatum rhizome, scrophularia root, achyranthes root, salvia root, alisma rhizome, codonopsis root, cornel fruit, loquat leaf, and schizandra chinensis.

4. The concentration method for the production of diabetes drugs as described in claim 1, It is characterized in that; The specific method for performing low-temperature concentration on the medicinal material extract through a stirring and concentration tank to obtain a concentrated medicinal material solution: Introduce the medicinal material extract into the stirring and concentration tank, and preset the concentration condition parameters of the stirring and concentration tank; Perform low-temperature concentration on the medicinal material extract based on the concentration condition parameters to obtain a concentrated solution; Real-time detect the concentration of the concentrated solution until the detected concentration meets the requirements and then stop to obtain a concentrated medicinal material solution.

5. The concentration method for the production of diabetes drugs according to claim 1, characterized in that; The specific method for discharging the concentrated medicinal material solution for subsequent processing to prepare diabetes drugs and at the same time cleaning the stirring and concentration tank: Discharge the concentrated medicinal material solution for subsequent processing to prepare diabetes drugs; Perform quality inspection on the diabetes drugs, and package the qualified diabetes drugs; Introduce hot water into the stirring and concentration tank for soaking for 1-2 hours, and use ultrasonic cleaning technology to clean the stirring and concentration tank after soaking.

6. A concentration device for the production of diabetes drugs, which is applied to the concentration method for the production of diabetes drugs according to any one of claims 1-5, characterized in that ； It includes a concentration tank, a control module, a pressure module, a heating module, a detection module, and a cleaning module. The concentration tank is respectively connected to the control module, the pressure module, the heating module, the detection module, and the cleaning module. The control module is respectively connected to the concentration tank, the pressure module, the heating module, the detection module, and the cleaning module; The concentration tank performs low-temperature concentration on the medicinal material extract therein based on the concentration condition parameters to obtain a concentrated medicinal material solution; The control module is used to control the concentration tank to perform low-temperature concentration on the medicinal material extract and preset the concentration condition parameters; The pressure module is used to adjust the pressure of the concentration tank; The heating module is used to heat the medicinal material extract in the concentration tank; The detection module is used to real-time detect the concentrated medicinal material solution in the concentration tank; The cleaning module is used to clean the concentration tank after the medicinal material extract is discharged to remove the remaining medicinal material extract.

7. The concentrating device for the production of diabetes drugs according to claim 6, characterized in that ； The cleaning module includes a water delivery unit, a liquid level unit, and a cleaning unit; The water delivery unit is used to introduce clean water into the concentration tank; The liquid level unit is used to detect the liquid level of clean water in the concentration tank and send a control signal to the control module; The cleaning unit cleans the mixing concentration tank based on ultrasonic cleaning technology.

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