Medicine granulation equipment and method

Abstract

The invention discloses a medicine granulation device and method, and belongs to the field of medicine preparation.The medicine granulation device comprises a viscosity detection module used for detecting the viscosity of raw materials in real time; a granulation module through which the received raw material is extruded to form granules; the granularity control module is used for calculating the rotating speed according to the granularity parameter input by the user and the viscosity of the raw material to obtain a rotating speed calculation result, generating a rotating speed control signal based on the rotating speed calculation result, and sending the rotating speed control signal to the granulation module, so that the granulation module executes a corresponding action based on the rotating speed control signal; the particle size control module converts particle size parameters input by a user into rotating speed control signals in real time, so that the extrusion action of the granulation module is dynamically matched with the particle forming speed, the defect that a traditional mode depends on manual experience for adjustment is overcome, and the particle size control precision is improved.

Description

Technical Field

[0001] The present invention relates to the technical field of drug preparation, and particularly relates to a drug granulation device and method. Background Art

[0002] In the prior art, granulators are widely used for the forming and processing of drug granules, which convert powder raw materials into granules with specific particle sizes by means of roller extrusion, wet adhesion, etc. However, as one of the core parameters for controlling the particle size, the roller speed still relies on manual experience for adjustment. This operation mode has the following significant defects: When manually setting the roller speed, it is easy to cause uneven particle size distribution due to differences in the operator's experience or subjective judgment deviation, making it difficult to meet the requirements of different drug physical properties (such as viscosity, hygroscopicity) for particle uniformity; Frequent start and stop of the equipment are required when adjusting the roller speed, resulting in the interruption of the production process, increased empty running energy consumption of the equipment, and a significant increase in the downtime cost; The fluctuation of particle size may directly affect the tablet weight difference, disintegration time limit, and drug dissolution rate of subsequent processes (such as tabletting), and even reduce the batch consistency and bioavailability of drugs. Summary of the Invention

[0003] Therefore, to address the above deficiencies, the present invention provides a drug granulation device and method herein to automatically control its own speed according to the set particle parameters, improving the control accuracy and regulation efficiency.

[0004] On the one hand, the present invention provides a drug granulation device herein, including:

[0005] A viscosity detection module for real-time detection of the viscosity of the raw material;

[0006] A granulation module that extrudes the received raw material to form granules;

[0007] A particle size control module that calculates the rotational speed based on the particle size parameters input by the user and the viscosity of the raw material, obtains the rotational speed calculation result, generates a rotational speed control signal based on the rotational speed calculation result, and sends the rotational speed control signal to the granulation module so that the granulation module performs corresponding actions based on the rotational speed control signal;

[0008] The granulation module includes:

[0009] A power unit;

[0010] A forming unit, where the forming unit includes a die holder, a storage cavity is provided in the upper part of the die holder, a fixed die is fixed on the upper surface of the die holder, the fixed die surrounds the outside of the storage cavity, and an array of particle discharge holes is provided on the side of the fixed die;

[0011] Rolling unit, which is connected to the power unit. The rolling unit includes a roller and a cutting plate. The power unit drives the roller to move along the inner side of the fixed mold and drives the cutting plate to move along the inner side of the fixed mold.

[0012] In the present invention, the particle size control module converts the particle size parameters input by the user into a rotational speed control signal in real time, enabling the extrusion action of the granulation module to be dynamically matched with the particle forming speed, solving the defect of traditional equipment relying on manual experience adjustment, and improving the particle size control accuracy. When the power unit drives the roller to continuously roll along the inner side of the fixed mold, a uniform shear force is formed, which, combined with the standardized aperture of the particle outlet hole array, reduces the dispersion degree of the particle size distribution and effectively reduces the phenomenon of caking or powdering. At the same time, the cutting plate moves synchronously with the roller and immediately performs mechanical cutting after the particles are extruded, reducing the particle adhesion rate.

[0013] Furthermore, a discharge port is also provided on the upper surface of the mold base, and a discharge chute fixed to the mold base is provided below the discharge port. The discharge chute is integrally inclined.

[0014] When the cutting plate rotates, it will drive the cut particles to move while performing the cutting work. The particles moving to the discharge port enter the discharge chute under the action of gravity, and the discharge chute guides the particles to slide along the direction of gravity, realizing the automatic discharge of the particles.

[0015] Furthermore, the bottom of the discharge chute has sieve holes, and a slag discharge pipe fixed to the mold base is provided below the sieve holes.

[0016] The sieve holes provided at the bottom of the discharge chute can screen out the debris and unformed powder generated during the particle forming process in real time. Combined with the directional collection of the fixed slag discharge pipe, the automatic separation of impurities and finished particles is realized, improving the purity of the finished particles.

[0017] Furthermore, the rolling unit further includes:

[0018] A bracket, which is connected to the power unit. The roller is installed on the bracket. The peripheral surface of the roller contacts the inner side of the fixed mold. The cutting plate is fixed to the bracket through a connecting rod;

[0019] An upper baffle plate, which is arranged above the roller and fixed to the bracket. The upper baffle plate is integrally inclined;

[0020] A lower partition plate, which is arranged below the roller and fixed to the bracket. The lower partition plate is integrally inclined, and the inclination direction of the lower partition plate is opposite to that of the upper baffle plate.

[0021] A material guiding channel is formed by the upper material baffle and the lower material separating baffle. During the rotation and extrusion of the rollers, the raw materials overflowing above the fixed mold are guided downward, and the raw materials scattered at the bottom are lifted upward, realizing the dynamic circulation and aggregation of the raw materials back to the core forming area of the fixed mold, thereby improving the utilization rate of the raw materials.

[0022] Further, the granulation module further includes a hood unit, which is integrally fixed on the upper surface of the mold base to enclose the fixed mold therein. The hood unit includes:

[0023] A hood body, which is fixed on the upper surface of the mold base, and a filter hole array is provided on one side of the hood body;

[0024] An air duct, which is arranged outside the hood body corresponding to the filter hole array and is communicated with the inside of the hood body through the filter hole array;

[0025] A feed pipe, which is arranged at the top of the hood body corresponding to the inside of the fixed mold and is communicated with the inside of the hood body.

[0026] The air duct can be communicated with a dryer, and the dryer drives the air flow to flow into the hood body, so that the formed particles can be pre-dried, the subsequent drying time of the particles is shortened, and the production efficiency is improved.

[0027] Further, the hood unit further includes a guide pipe corresponding to the feed pipe;

[0028] A baffle is fixed on the top of the fixed mold to partially enclose the guide pipe therein.

[0029] Further, the particle size control module includes:

[0030] A first parameter setting unit for the user to input parameters;

[0031] A first data receiving unit for receiving the parameters input by the user through the first parameter setting unit;

[0032] A rotation speed calculation unit for calculating the rotation speed according to the input parameters to obtain a rotation speed calculation result;

[0033] An output control unit for generating a rotation speed control signal and sending the rotation speed control signal to the granulation module so that the granulation module performs corresponding actions based on the rotation speed control signal.

[0034] Further, the granulation equipment further includes:

[0035] A temperature detection module for detecting the temperature of the raw materials;

[0036] A humidity detection module for detecting the humidity of the raw materials;

[0037] The particle size control module further includes a rotational speed compensation unit. The rotational speed compensation unit obtains the raw material temperature and raw material humidity received by the first data receiving unit, and performs compensation calculation on the rotational speed calculation result based on the raw material temperature and raw material humidity to obtain a rotational speed compensation calculation result, so that the output control unit generates a rotational speed control signal according to the rotational speed compensation calculation result.

[0038] The rotational speed calculation unit calculates the initial rotational speed based on the raw material physical property parameters input by the user. At the same time, the rotational speed compensation unit receives the raw material temperature from the temperature detection module and the raw material humidity from the humidity detection module in real time, dynamically corrects the rotational speed deviation, and improves the rotational speed control accuracy.

[0039] Furthermore, the particle size control module further includes a first communication unit;

[0040] The granulation equipment further includes a user terminal module, and the user terminal module includes:

[0041] A second parameter setting unit for the user to input parameters;

[0042] A second data receiving unit for receiving the parameters input by the user through the second parameter setting unit;

[0043] A second communication unit for data transmission with the first communication unit to send the parameters input through the second parameter setting unit to the second communication unit, or receive the parameters input through the first parameter setting unit, the rotational speed compensation calculation result, the raw material temperature, and the raw material humidity sent through the first communication unit.

[0044] Through the communication between the first communication unit and the second communication unit, the user terminal module can remotely send the particle target parameters to the particle size control module, and at the same time receive the rotational speed compensation calculation result and the raw material temperature and humidity data in real time, realizing cross-level data intercommunication.

[0045] On the other hand, the present invention also provides a drug granulation method. This granulation method uses the above-mentioned drug granulation equipment, and this granulation method includes:

[0046] Obtain the user input parameters, and the user input parameters are the raw material particle size;

[0047] Specifically, the user can input the particle size parameter through the second parameter setting unit of the user terminal module. After the second data unit receives the particle size parameter input by the user, it transmits the particle size parameter to the second communication unit, and the second communication unit sends it to the first communication unit of the particle size control module, and the first communication unit transmits the particle size parameter to the first data receiving unit; in addition, the user can also directly input the particle size parameter using the first parameter setting unit on site;

[0048] Obtain the raw material viscosity data, calculate the rotational speed based on the user input parameters and the raw material viscosity data, and obtain the rotational speed calculation result;

[0049] Specifically, the viscosity data is obtained by the viscosity detection module through real-time acquisition of the raw material. The rotational speed is calculated based on the particle size parameter input by the user and the real-time viscosity data detected, so as to obtain the rotational speed calculation. The specific method of this rotational speed calculation is as follows:

[0050]

[0051] Among them, ω0 is the rotational speed, with the unit of revolutions per minute; K is the coupling coefficient between the equipment and the material; D is the particle size, with the unit of millimeter; n is the kinetic index; γ0 is the reference viscosity, with the unit of Pascal-second; γ1 is the detected viscosity, with the unit of Pascal-second;

[0052] Obtain the raw material humidity and raw material temperature, perform compensation calculation on the rotational speed calculation result based on the raw material humidity and raw material temperature, and obtain the rotational speed compensation calculation result;

[0053] Specifically, the humidity parameter of the raw material is obtained in real time through the humidity detection module, and the temperature parameter of the raw material is obtained in real time through the temperature detection module. Then, compensation calculation is performed on the rotational speed according to the real-time humidity and real-time temperature of the raw material, so as to improve the control accuracy of the rotational speed. The calculation method of the rotational speed compensation is as follows:

[0054] ω1 = ω0 + (H1 - H2)w H U H -(T1 - T2)w T U T ;

[0055] Among them, ω1 is the compensated rotational speed, with the unit of revolutions per minute; H1 is the real-time relative humidity of the raw material; H2 is the reference relative humidity of the raw material; w H is the humidity influence weight; U H is the humidity compensation coefficient, with the unit of revolutions per minute per relative humidity; T1 is the real-time raw material temperature, with the unit of degree Celsius; T2 is the reference temperature, with the unit of degree Celsius; w T is the temperature influence weight; U T is the temperature compensation coefficient, with the unit of revolutions per minute per degree Celsius;

[0056] Generate a rotational speed control signal according to the rotational speed compensation calculation result, and send the rotational speed control signal to the granulation module, so that the granulation module performs corresponding actions based on the rotational speed control signal;

[0057] The granulation module receives a rotational speed control signal. The power unit drives the rolling unit to rotate at a preset speed based on the rotational speed control signal. Meanwhile, raw materials enter the forming unit through the feed pipe. The material guiding channel formed by the upper baffle plate and the lower partition plate guides the raw materials overflowing above the fixed mold downward and the raw materials scattered at the bottom upward, dynamically circulating and gathering the raw materials back to the core forming area of the fixed mold. The rotating rolling unit extrudes the raw materials in the core forming area, causing the raw materials to bond under the extrusion of the rollers and extruding them outwards through the particle outlet holes of the fixed mold. The rotating cutting plate cuts off the extruded raw materials to form particles and drives the cut particles to move. The particles moving to the discharge port enter the discharge chute under the action of gravity. The discharge chute guides the particles to slide along the direction of gravity. When passing through the sieve holes provided at the bottom of the discharge chute, the debris and unformed powder generated during the particle forming process are screened out. The qualified particles slide along the discharge chute to the qualified area, while the debris and unformed powder fall to the waste area on the side.

[0058] The present invention has the following advantages: The present invention converts the particle size parameters input by the user into a rotational speed control signal in real time through the particle size control module, enabling the extrusion action of the granulation module to be dynamically matched with the particle forming speed, solving the defect of traditional equipment relying on manual experience adjustment, and improving the particle size control accuracy. When the power unit drives the rollers to continuously roll along the inner side of the fixed mold, a uniform shear force is formed, which, combined with the standardized aperture of the particle outlet hole array, reduces the dispersion degree of the particle size distribution and effectively reduces the phenomenon of caking or powdering. At the same time, in the present application, the cutting plate and the rollers move synchronously, and mechanical cutting is immediately performed after the particles are extruded, reducing the particle adhesion rate. Description of the Drawings

[0059] Figure 1 is the logical structure schematic diagram of the granulation equipment;

[0060] Figure 2 is Figure 1 the structure schematic diagram of the granulation module in the shown granulation equipment;

[0061] Figure 3 is Figure 2 the internal structure schematic diagram of the shown granulation module;

[0062] Figure 4 is Figure 2 the partial structure schematic diagram of the shown granulation module;

[0063] Figure 5 is Figure 3 the structure schematic diagram of the rolling unit in the shown granulation module;

[0064] Figure 6 is Figure 1 the logical structure schematic diagram of the particle size control module and the user terminal module in the shown granulation equipment;

[0065] In the figure: 10, hood unit; 11, feed pipe; 12, hood body; 13, air duct; 14, material guide pipe;

[0066] 20, power unit; 30, forming unit; 31, baffle; 32, fixed mold; 33, mold base; 34, discharge port; 35, slag discharge pipe; 36, discharge chute; 40, rolling unit; 41, connecting rod; 42, cutting plate; 43, upper material retaining plate; 44, lower material separating plate; 45, roller; 46, bracket;

[0067] 100, temperature detection module; 200, viscosity detection module; 300, humidity detection module; 400, granulation module; 500, particle size control module; 510, first parameter setting unit; 520, first display unit; 530, rotation speed calculation unit; 540, output control unit; 550, rotation speed compensation unit; 560, first communication unit; 570, first data receiving unit; 600, user terminal module; 610, second parameter setting unit; 620, second data receiving unit; 630, second communication unit; 640, second display unit. Detailed implementation manners

[0068] The embodiments of the present application will be described in detail below. Examples of the embodiments are shown in the accompanying drawings, where the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are intended to explain the present application and should not be construed as limiting the present application.

[0069] In this article, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "comprising", "including" or any other variant thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements not only includes those elements, but also includes other elements not expressly listed, or elements inherent to such process, method, article or device.

[0070] As described in the background art, when manually setting the rotation speed of the roller, it is easy to cause uneven particle size distribution due to differences in operator experience or subjective judgment deviation, and it is difficult to meet the requirements for particle uniformity of different drug physical properties (such as viscosity, hygroscopicity); when adjusting the rotation speed of the roller, the equipment needs to be frequently started and stopped, resulting in interruption of the production process, increased energy consumption of the equipment during idling, and a significant increase in the downtime cost; fluctuations in particle size may directly affect the weight difference, disintegration time limit and drug dissolution rate of subsequent processes (such as tabletting), and even reduce the batch consistency and bioavailability of drugs.

[0071] Therefore, in order to solve the above technical problems existing in the current technology, the present invention hereby proposes the following embodiments.

[0072] Embodiment 1:

[0073] This embodiment hereby provides a pharmaceutical granulating device, as Figure 1 shown. The pharmaceutical granulating device includes:

[0074] A viscosity detection module 200 for detecting the viscosity of the raw material in real time;

[0075] A granulating module 500 that extrudes the received raw material to form granules;

[0076] A particle size control module 400 that calculates the rotation speed based on the particle size parameter input by the user and the raw material viscosity, obtains the rotation speed calculation result, generates a rotation speed control signal based on the rotation speed calculation result, and sends the rotation speed control signal to the granulating module so that the granulating module performs corresponding actions based on the rotation speed control signal;

[0077] As Figure 2 、 3 shown, the granulating module includes:

[0078] A power unit 20;

[0079] A forming unit 30, as Figure 3 、 4 shown. The forming unit includes a die base 33 with a storage cavity on the upper part of the die base. A fixed die 32 is fixed on the upper surface of the die base. The fixed die surrounds the outside of the storage cavity, and an array of particle discharge holes is provided on the side surface of the fixed die;

[0080] A rolling unit 40, which is connected to the power unit. As Figure 5 shown, the rolling unit includes a roller 45 and a cutting plate 42. The power unit drives the roller to move along the inner side surface of the fixed die and drives the cutting plate to move along the inner side surface of the fixed die.

[0081] During use, the user inputs the particle size parameter. After the particle size control module receives the particle size parameter input by the user, it calculates the output rotation speed of the power unit according to this parameter, obtains the rotation speed calculation result, generates a rotation speed control signal based on the rotation speed calculation result, and sends the rotation speed control signal to the granulating module. The granulating module controls the power unit to output a rotation speed corresponding to the rotation speed calculation result according to this rotation speed control signal, so as to drive the rolling unit to rotate at this rotation speed. The rotating roller moves along the inner side surface of the fixed die, extrudes the raw material towards the inner side surface of the fixed die, so that the raw material adheres under the extrusion action of the roller and is extruded outwards from the particle discharge holes of the fixed die. The rotating cutting plate cuts off the extruded raw material to form granules.

[0082] In this embodiment, the particle size control module converts the particle size parameters input by the user into rotational speed control signals in real time, enabling the extrusion action of the granulation module to be dynamically matched with the particle forming speed, solving the defect of traditional equipment relying on manual experience for adjustment, and improving the particle size control accuracy. When the power unit drives the roller to continuously roll along the inner side of the fixed die, a uniform shearing force is formed, and in cooperation with the standardized aperture of the particle outlet hole array, the dispersion degree of the particle size distribution is reduced, effectively reducing the phenomena of caking or powdering. At the same time, the cutting plate moves synchronously with the roller, and mechanical cutting is immediately performed after the particles are extruded, reducing the particle adhesion rate.

[0083] Specifically, the power unit can be selected as a servo motor, and the servo motor can be connected to the rolling unit through a transmission mechanism, such as a belt pulley transmission mechanism, a gear transmission mechanism, etc.

[0084] Exemplarily, as Figure 3 、 4 shown, a discharge port 34 can also be opened on the upper surface of the die holder, and a discharge chute 36 fixed to the die holder can be arranged below the discharge port. The discharge chute is integrally inclined.

[0085] When the cutting plate rotates, it will drive the cut particles to move while performing the cutting work. The particles moving to the discharge port enter the discharge chute under the action of gravity, and the discharge chute guides the particles to slide along the direction of gravity, realizing the automatic discharge of the particles.

[0086] Exemplarily, the bottom of the discharge chute has sieve holes, and a slag discharge pipe 35 fixed to the die holder is arranged below the sieve holes.

[0087] The sieve holes provided at the bottom of the discharge chute can screen out the debris and unformed powder generated during the particle forming process in real time. Combined with the directional collection of the fixed slag discharge pipe, the automatic separation of impurities and finished particles is realized, improving the purity of the finished particles.

[0088] Exemplarily, as Figure 5 shown, the rolling unit may further include:

[0089] A bracket 46, which is connected to the power unit. The roller is installed on the bracket. The peripheral surface of the roller contacts the inner side of the fixed die. The cutting plate is fixed to the bracket through a connecting rod 41;

[0090] An upper baffle 43, which is arranged above the roller and fixed to the bracket. The upper baffle is integrally inclined;

[0091] A lower partition plate 44, which is arranged below the roller and fixed to the bracket. The lower partition plate is integrally inclined, and the inclination direction of the lower partition plate is opposite to that of the upper baffle.

[0092] A material guiding channel is formed by the upper baffle plate and the lower partition plate. During the rotation and extrusion of the rollers, the raw materials overflowing above the fixed mold are diverted downward, and the raw materials scattered at the bottom are lifted upward, realizing the dynamic circulation and aggregation of the raw materials back to the core forming area of the fixed mold, thereby improving the utilization rate of the raw materials.

[0093] Exemplarily, as Figure 1 shown, the granulation module further includes a hood unit 10, which is integrally fixed on the upper surface of the mold base to enclose the fixed mold therein, as Figure 2 shown, the hood unit includes:

[0094] A hood body 12, which is fixed on the upper surface of the mold base, and a filter hole array is provided on one side of the hood body;

[0095] An air duct 13, which is arranged outside the hood body corresponding to the filter hole array and is communicated with the inside of the hood body through the filter hole array;

[0096] A feed pipe 11, which is arranged at the top of the hood body corresponding to the inside of the fixed mold and is communicated with the inside of the hood body.

[0097] In this embodiment, the air duct can be connected to a drying device, and the airflow with a preset temperature generated by the drying device flows into the space between the hood body and the forming unit to pre-dry the formed particles. In addition, the feed pipe can be connected to a feeding device, and the raw materials are continuously injected into the inside of the forming unit through the feed pipe by the feeding device.

[0098] In this embodiment, the air duct can be communicated with a dryer, and the dryer drives the airflow to flow into the hood body, which can pre-dry the formed particles, shorten the subsequent drying time of the particles, and improve the production efficiency.

[0099] Exemplarily, the hood unit may further include a guide pipe 14 corresponding to the feed pipe;

[0100] A baffle 31 is fixed on the top of the fixed mold to partially enclose the guide pipe therein.

[0101] By guiding the raw materials through the guide pipe and blocking by the baffle, it is possible to prevent the raw materials from splashing outside the forming unit when entering the forming unit or when the rolling unit is working.

[0102] Exemplarily, as Figure 6 shown, the particle size control module includes:

[0103] A first parameter setting unit 510 for the user to input parameters;

[0104] A first data receiving unit 570 for receiving the parameters input by the user through the first parameter setting unit;

[0105] A rotational speed calculation unit 530, configured to perform rotational speed calculation based on input parameters to obtain a rotational speed calculation result;

[0106] An output control unit 540, configured to generate a rotational speed control signal and send the rotational speed control signal to a granulation module, so that the granulation module performs corresponding actions based on the rotational speed control signal.

[0107] Exemplarily, the granulation device may further include:

[0108] A temperature detection module 100, configured to detect the raw material temperature;

[0109] A humidity detection module 300, configured to detect the raw material humidity;

[0110] The particle size control module further includes a rotational speed compensation unit 550. The rotational speed compensation unit acquires the raw material temperature and raw material humidity received by the first data receiving unit, and performs compensation calculation on the rotational speed calculation result based on the raw material temperature and raw material humidity to obtain a rotational speed compensation calculation result, so that the output control unit generates a rotational speed control signal according to the rotational speed compensation calculation result.

[0111] The rotational speed calculation unit calculates an initial rotational speed based on the raw material physical property parameters input by the user. At the same time, the rotational speed compensation unit receives the raw material temperature of the temperature detection module and the raw material humidity of the humidity detection module in real time, dynamically corrects the rotational speed deviation, and improves the rotational speed control accuracy.

[0112] Exemplarily, the particle size control module further includes a first communication unit 560;

[0113] As Figure 1 shown, the granulation device may further include a user terminal module 600. As Figure 6 shown, the user terminal module includes:

[0114] A second parameter setting unit 610, which is used for the user to input parameters;

[0115] A second data receiving unit 620, configured to receive the parameters input by the user through the second parameter setting unit;

[0116] A second communication unit 630, through which data transmission is performed with the first communication unit to send the parameters input through the second parameter setting unit to the second communication unit, or receive the parameters input through the first parameter setting unit, the rotational speed compensation calculation result, the raw material temperature, and the raw material humidity sent through the first communication unit.

[0117] By communicating between the first communication unit and the second communication unit, the user terminal module can remotely send particle target parameters to the particle size control module, and at the same time receive the rotational speed compensation calculation result and the raw material temperature and humidity data in real time, realizing cross-level data intercommunication.

[0118] Specifically, the first parameter setting unit and the second parameter setting unit can select a physical instruction-driven interaction device (such as a keyboard) and a graphical touch-driven interaction device (such as a touch screen). The first communication unit and the second communication unit can select a Bluetooth module, a 2.4GHz wireless module, a serial communication module, etc.

[0119] In this embodiment, the viscosity detection module, the humidity detection module, and the temperature detection module are sensors for detecting the viscosity, humidity, and temperature of the raw materials. In addition, the user terminal module further includes a second display unit 640, which is used to receive the data obtained by the second data receiving unit and output the data to a specified display window. Similarly, the particle size control module may include a first display unit 520, which is used to receive the data obtained by the first data receiving unit, the data calculated by the rotation speed calculation unit, the data calculated by the rotation speed compensation unit, and the relevant data generated by the output control unit, etc., and output each data to a specified display window.

[0120] In this embodiment, the calculation method of the rotation speed calculation is:

[0121]

[0122] Where ω0 is the rotation speed, with the unit of revolutions per minute; K is the coupling coefficient between the device and the material; D is the particle size, with the unit of millimeters, n is the kinetic index; γ0 is the reference viscosity, with the unit of Pascal-seconds; γ1 is the detected viscosity, with the unit of Pascal-seconds.

[0123] Exemplarily, in this embodiment, the coupling coefficient between the device and the material is calibrated through experiments, and in this embodiment, the coupling coefficient between the device and the material is taken as K = 62. The kinetic index is related to the viscosity and shear strength of the material, and in this embodiment, n = 0.75 is taken.

[0124] The calculation method of the rotation speed compensation calculation is:

[0125] ω1 = ω0 + (H1 - H2)w H U H -(T1 - T2)w T U T ;

[0126] Where ω1 is the compensated rotation speed, with the unit of revolutions per minute; H1 is the real-time relative humidity of the raw material; H2 is the reference relative humidity of the raw material; w H is the humidity influence weight; U H is the humidity compensation coefficient, with the unit of revolutions per minute per relative humidity; T1 is the real-time raw material temperature, with the unit of degrees Celsius; T2 is the reference temperature, with the unit of degrees Celsius; w T is the temperature influence weight; U Tis the temperature compensation coefficient, with the unit of revolutions per minute per degree Celsius.

[0127] Exemplarily, the humidity compensation coefficient can be taken as U H = 0.45, the humidity influence weight can be taken as W H = 0.56, the temperature compensation coefficient can be taken as U T = 0.35, the temperature influence weight can be taken as W T = 0.44.

[0128] Example 2:

[0129] On the other hand, the present invention also provides a method for granulating drugs. This granulation method uses one of the above-mentioned drug granulation devices, and this granulation method includes:

[0130] Obtain user input parameters, where the user input parameters are the particle size of the raw materials;

[0131] Specifically, the user can input the particle size parameter through the second parameter setting unit of the user terminal module. After the second data unit receives the input particle size parameter from the user, it transmits the particle size parameter to the second communication unit, which sends it to the first communication unit of the particle size control module, and the first communication unit transmits the particle size parameter to the first data receiving unit. In addition, the user can also directly input the particle size parameter on-site using the first parameter setting unit.

[0132] Obtain the raw material viscosity data, calculate the rotational speed based on the user input parameters and the raw material viscosity data, and obtain the rotational speed calculation result;

[0133] Specifically, the viscosity data is obtained by the viscosity detection module through real-time collection of the raw materials. The rotational speed is calculated through the particle size parameter input by the user and the detected real-time viscosity data, so as to obtain the rotational speed calculation. The specific method of this rotational speed calculation is as follows:

[0134]

[0135] Among them, ω0 is the rotational speed, with the unit of revolutions per minute; K is the coupling coefficient between the device and the material; D is the particle size, with the unit of millimeter, n is the kinetic index; γ0 is the reference viscosity, with the unit of pascal-second; γ1 is the detected viscosity, with the unit of pascal-second.

[0136] Exemplarily, in this embodiment, the coupling coefficient between the device and the material is calibrated through experiments. In this embodiment, the coupling coefficient between the device and the material is taken as K = 62. The kinetic index is related to the viscosity and shear strength of the material. In this embodiment, n = 0.75 is taken.

[0137] Obtain the raw material humidity and raw material temperature, and perform compensation calculation on the rotational speed calculation result according to the raw material humidity and raw material temperature to obtain the rotational speed compensation calculation result;

[0138] Specifically, in this embodiment, the humidity detection module is used to obtain the humidity parameter of the raw material in real time, and the temperature detection module is used to obtain the temperature parameter of the raw material in real time. Then, the rotation speed is compensated and calculated according to the real-time humidity and real-time temperature of the raw material, so as to improve the control accuracy of the rotation speed. The calculation method of the rotation speed compensation is as follows:

[0139] H1 = ω0 + (H1 - ω2)w H U H -(T1 - T2)w T U T ;

[0140] Where, ω1 is the compensated rotation speed, with the unit of revolutions per minute; H1 is the real-time relative humidity of the raw material; H2 is the reference relative humidity of the raw material; w H is the humidity influence weight; U H is the humidity compensation coefficient, with the unit of revolutions per minute per relative humidity; T1 is the real-time raw material temperature, with the unit of degree Celsius; T2 is the reference temperature, with the unit of degree Celsius; w T is the temperature influence weight; U T is the temperature compensation coefficient, with the unit of revolutions per minute per degree Celsius.

[0141] Exemplarily, the humidity compensation coefficient can be taken as U H = 0.45, the humidity influence weight can be taken as W H = 0.56, the temperature compensation coefficient can be taken as U T = 0.35, and the temperature influence weight can be taken as W T = 0.44.

[0142] Generate a rotation speed control signal according to the rotation speed compensation calculation result, and send the rotation speed control signal to the granulation module, so that the granulation module performs corresponding actions based on the rotation speed control signal;

[0143] The granulation module receives a rotational speed control signal, and the power unit drives the rolling unit to rotate at a preset speed based on the rotational speed control signal. Meanwhile, the raw material enters the forming unit through the feed pipe. The material guiding channel formed by the upper baffle plate and the lower partition plate guides the raw material overflowing above the fixed mold downward and the raw material scattered at the bottom upward, dynamically circulating and gathering the raw material back to the core forming area of the fixed mold. The rotating rolling unit extrudes the raw material in the core forming area so that the raw material adheres under the extrusion of the rollers and is extruded outwards through the particle outlet holes of the fixed mold. The rotating cutting plate cuts the extruded raw material to form particles and drives the cut particles to move. The particles moving to the discharge port enter the discharge chute under the action of gravity, and the discharge chute guides the particles to slide along the direction of gravity. When passing through the sieve holes provided at the bottom of the discharge chute, the debris and unformed powder generated during the particle forming process are screened out. The qualified particles slide along the discharge chute to the qualified area, and the debris and unformed powder fall to the waste area on the side.

[0144] The above description of the disclosed embodiments enables those skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein can be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but rather to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A pharmaceutical granulation device, characterized in that, Comprising: A viscosity detection module for detecting the viscosity of the raw material in real time; A granulation module that extrudes the received raw material to form particles; A particle size control module that calculates the rotation speed based on the particle size parameter input by the user and the viscosity of the raw material, obtains the rotation speed calculation result, generates a rotation speed control signal based on the rotation speed calculation result, and sends the rotation speed control signal to the granulation module so that the granulation module performs corresponding actions based on the rotation speed control signal; The granulation module includes: A power unit; A forming unit, the forming unit includes a die base, there is a material storage cavity above the die base, a fixed die is fixed on the upper surface of the die base, the fixed die surrounds the outside of the material storage cavity, and a grain outlet hole array is arranged on the side surface of the fixed die; A rolling unit, the rolling unit is connected to the power unit, the rolling unit includes a roller and a cutting plate, and the power unit drives the roller to move along the inner side surface of the fixed die and drives the cutting plate to move along the inner side surface of the fixed die.

2. A pharmaceutical granulation device according to claim 1, characterized in that, An outlet is also opened on the upper surface of the die base, and a discharge chute fixed to the die base is arranged below the outlet, and the discharge chute is integrally inclined.

3. A pharmaceutical granulation device according to claim 2, characterized in that, The bottom of the discharge chute has sieve holes, and a slag discharge pipe fixed to the die base is arranged below the sieve holes.

4. A pharmaceutical granulation device according to claim 1, characterized in that, The rolling unit further includes: A bracket, the bracket is connected to the power unit, the roller is installed on the bracket, the peripheral surface of the roller contacts the inner side surface of the fixed die, and the cutting plate is fixed to the bracket through a connecting rod; An upper material baffle, the upper material baffle is arranged above the roller and is fixed to the bracket, and the upper material baffle is integrally inclined; A lower material separation baffle, the lower material separation baffle is arranged below the roller and is fixed to the bracket, the lower material separation baffle is integrally inclined, and the inclination direction of the lower material separation baffle is opposite to that of the upper material baffle.

5. A pharmaceutical granulation device according to claim 1, characterized in that, The granulation module further includes a hood unit, the hood unit is integrally fixed on the upper surface of the die base to wrap the fixed die inside, and the hood unit includes: A hood body, the hood body is fixed on the upper surface of the die base, and a filter hole array is arranged on one side of the hood body; An air duct, the air duct is arranged outside the hood body corresponding to the filter hole array and is communicated with the inside of the hood body through the filter hole array; A feed pipe, the feed pipe is arranged at the top of the hood body corresponding to the inside of the fixed die and is communicated with the inside of the hood body.

6. The pharmaceutical granulation equipment according to claim 5, characterized in that, The hood unit further includes a guide pipe corresponding to the feed pipe; A baffle is fixed on the top of the fixed die to partially wrap the guide pipe inside.

7. A pharmaceutical granulation device according to claim 1, characterized in that, The particle size control module includes: A first parameter setting unit for the user to input parameters; A first data receiving unit for receiving the parameters input by the user through the first parameter setting unit; A rotation speed calculation unit for calculating the rotation speed according to the input parameters and obtaining the rotation speed calculation result; An output control unit for generating a rotation speed control signal and sending the rotation speed control signal to the granulation module so that the granulation module performs corresponding actions based on the rotation speed control signal.

8. A pharmaceutical granulation device according to claim 7, characterized in that, The granulation equipment further includes: A temperature detection module for detecting the temperature of the raw material; A humidity detection module for detecting the humidity of the raw material; The particle size control module further includes a rotational speed compensation unit. The rotational speed compensation unit obtains the raw material temperature and raw material humidity received by the first data receiving unit, and performs compensation calculation on the rotational speed calculation result based on the raw material temperature and raw material humidity to obtain a rotational speed compensation calculation result, so that the output control unit generates a rotational speed control signal according to the rotational speed compensation calculation result.

9. A pharmaceutical granulation device according to claim 1, characterized in that, The particle size control module further includes a first communication unit; The granulation device further includes a client module, and the client module includes: A second parameter setting unit for a user to input parameters; A second data receiving unit for receiving the parameters input by the user through the second parameter setting unit; A second communication unit for data transmission with the first communication unit through the second communication unit to send the parameters input through the second parameter setting unit to the second communication unit, or receive the parameters input through the first parameter setting unit, the rotational speed compensation calculation result, the raw material temperature, and the raw material humidity sent through the first communication unit.

10. A method for granulating a drug, characterized in that, This granulation method uses a pharmaceutical granulation device described in any one of claims 1 to 9 of the above claims. This granulation method includes: Obtaining user input parameters, where the user input parameters are the particle size of the raw material particles; Specifically, the user can input the particle size parameters through the second parameter setting unit of the client module. After the second data unit receives the particle size parameters input by the user, it transmits the particle size parameters to the second communication unit, and the second communication unit sends them to the first communication unit of the particle size control module, and the first communication unit transmits the particle size parameters to the first data receiving unit; in addition, the user can also directly input the particle size parameters on-site using the first parameter setting unit; Obtaining the raw material viscosity data, and performing rotational speed calculation based on the user input parameters and the raw material viscosity data to obtain a rotational speed calculation result; Specifically, the viscosity data is obtained by the viscosity detection module through real-time collection of the raw material. The rotational speed calculation is performed through the particle size parameters input by the user and the detected real-time viscosity data, so as to obtain the rotational speed calculation. The specific method of this rotational speed calculation is as follows: Among them, ω0 is the rotational speed, with the unit of revolutions per minute; K is the coupling coefficient between the device and the material; D is the particle size, with the unit of millimeters, n is the kinetic index; γ0 is the reference viscosity, with the unit of pascal-seconds; γ1 is the detected viscosity, with the unit of pascal-seconds; Obtaining the raw material humidity and raw material temperature, and performing compensation calculation on the rotational speed calculation result according to the raw material humidity and raw material temperature to obtain a rotational speed compensation calculation result; Specifically, the humidity parameter of the raw material is obtained in real time through the humidity detection module, and the temperature parameter of the raw material is obtained in real time through the temperature detection module. Then, the rotational speed is compensated and calculated according to the real-time humidity and real-time temperature of the raw material, so as to improve the control accuracy of the rotational speed. The calculation method of the rotational speed compensation is as follows: ω1 = ω0 + (H1 - H2)wHUH - (T1 - T2)w T U T ; Among them, ω1 is the compensation rotational speed, with the unit of revolutions per minute; H1 is the real-time relative humidity of the raw material; H2 is the reference relative humidity of the raw material; w H is the humidity influence weight; U H is the humidity compensation coefficient, with the unit of revolutions per minute per relative humidity; T1 is the real-time raw material temperature, with the unit of degree Celsius; T2 is the reference temperature, with the unit of degree Celsius; w T is the temperature influence weight; U T is the temperature compensation coefficient, with the unit of revolutions per minute per degree Celsius; Generating a rotational speed control signal according to the rotational speed compensation calculation result, and sending the rotational speed control signal to the granulation module so that the granulation module performs corresponding actions based on the rotational speed control signal; The granulation module receives a rotational speed control signal. The power unit drives the rolling unit to rotate at a preset speed based on the rotational speed control signal. Meanwhile, the raw material enters the forming unit through the feed pipe. The material guiding channel formed by the upper baffle plate and the lower partition plate guides the raw material overflowing above the fixed mold downward and the raw material scattered at the bottom upward, dynamically circulating and gathering the raw material back to the core forming area of the fixed mold. The rotating rolling unit extrudes the raw material in the core forming area so that the raw material adheres under the extrusion of the rollers and is extruded outwards through the particle outlet holes of the fixed mold. The rotating cutting plate cuts the extruded raw material to form particles and drives the cut particles to move. The particles moving to the discharge port enter the discharge chute under the action of gravity. The discharge chute guides the particles to slide along the direction of gravity. When passing through the sieve holes arranged at the bottom of the discharge chute, the debris and unformed powder generated during the particle forming process are screened out. The qualified particles slide along the discharge chute to the qualified area, and the debris and unformed powder fall to the waste area on the side.

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