Sample analysis system and method, and cell image analysis device

Abstract

A sample analysis system (100), a method, and a cell image analysis device (104), the sample analysis system (100) comprising: a blood cell analyzer (101), a smear preparation device (103), a cell image analysis device (104), and a control device (102), the control device (102) obtaining a detection result of at least a sample from the blood cell analyzer (101), when at least one sample contains a sample needing to be analyzed through the cell image analysis device (104), the control device (102) can control the shooting condition adopted by the cell image analysis device (104) according to the value of at least one cell in the detection result of the sample to be analyzed. Therefore, the cell image analysis device (104) can automatically select the shooting conditions matched with the detection results for shooting according to different detection results of the to-be-analyzed sample, so that cell image shooting and analysis can be performed on the smear of the to-be-analyzed sample in a targeted manner by adopting the matched shooting conditions. The processing efficiency and the processing accuracy of the cell image analyzer (104) are improved.

Description

[0001] This application is a divisional application of the invention patent application with the application date of December 31, 2019, application number 201980006738.X, and invention name "Sample Analysis System, Method and Cell Image Analysis Device". Technical Field

[0002] The present invention relates to medical device technology, and in particular to a sample analysis system, method and cell image analysis device. Background Art

[0003] Currently, a cell image analysis device (such as a film reader) can take pictures and analyze smears of samples to be analyzed. Before taking pictures and analyzing the sample smears, the cell image analysis device displays a mode designation interface, and the user selects the analysis mode of the current cell image analysis device on the mode designation interface, and takes pictures of the smears of the samples to be analyzed under the shooting conditions specified by the analysis mode, resulting in low processing efficiency and processing accuracy of the cell image analysis device. Summary of the Invention

[0004] Embodiments of the present invention provide a sample analysis system, method and cell image analysis device for selecting shooting conditions for a sample to be analyzed according to the blood routine test results of the sample to be analyzed, so as to improve processing efficiency and processing accuracy.

[0005] The technical solutions of the embodiments of the present invention are implemented as follows:

[0006] On the one hand, embodiments of the present invention provide a sample analysis system, including:

[0007] A blood cell analyzer for detecting at least one sample to obtain a detection result of the at least one sample;

[0008] A control device for obtaining the detection result of the at least one sample;

[0009] A smear preparation device for preparing a smear of a sample to be analyzed by a cell image analysis device to obtain a smear of the sample to be analyzed;

[0010] A cell image analysis device for taking pictures and analyzing the smear of the sample to be analyzed to obtain a cell image and a cell image analysis result of the sample to be analyzed;

[0011] The control device is further configured to:

[0012] If the value of at least one type of cell in the detection result of the sample to be analyzed is less than a preset threshold, control the cell image analysis device to capture the smear of the sample to be analyzed under the first shooting condition to obtain an image of the at least one type of cell;

[0013] If the value of at least one type of cell in the detection result of the sample to be analyzed is not less than the preset threshold, control the cell image analysis device to capture the smear of the sample to be analyzed under a second shooting condition different from the first shooting condition to obtain an image of the at least one type of cell;

[0014] Wherein, the number of cell images captured by the cell image analysis device under the first shooting condition is greater than the number of cell images captured under the second shooting condition.

[0015] On the other hand, an embodiment of the present invention provides a sample analysis system, including:

[0016] A blood cell analyzer for detecting at least one sample to obtain a detection result of the at least one sample;

[0017] A control device for obtaining the detection result of the at least one sample;

[0018] A smear preparation device for preparing a smear of a sample to be analyzed by a cell image analysis device to obtain a smear of the sample to be analyzed;

[0019] A cell image analysis device for capturing and analyzing the smear of the sample to be analyzed to obtain a cell image and a cell image analysis result of the sample to be analyzed;

[0020] The control device is further configured to:

[0021] If the value of at least one type of cell in the detection result of the sample to be analyzed is less than a preset threshold, control the cell image analysis device to capture the smear of the sample to be analyzed under the first shooting condition to obtain an image of the at least one type of cell;

[0022] If the value of at least one type of cell in the detection result of the sample to be analyzed is not less than the preset threshold, control the cell image analysis device to capture the smear of the sample to be analyzed under a second shooting condition different from the first shooting condition to obtain an image of the at least one type of cell;

[0023] Wherein, the value of the at least one type of cell includes a value related to cell volume.

[0024] On yet another aspect, an embodiment of the present invention provides a sample analysis system, including:

[0025] A blood cell analyzer for detecting at least one sample to obtain the detection result of the at least one sample;

[0026] A control device for obtaining the detection result of the at least one sample;

[0027] A smear preparation device for preparing a smear of a sample to be analyzed by a cell image analysis device to obtain a smear of the sample to be analyzed;

[0028] A cell image analysis device for photographing and analyzing the smear of the sample to be analyzed to obtain the cell image and cell image analysis result of the sample to be analyzed;

[0029] The control device is further configured to:

[0030] If the value of at least one type of cell in the detection result of the sample to be analyzed is less than a preset threshold, control the cell image analysis device to photograph the smear of the sample to be analyzed under a first photographing condition to obtain an image of the at least one type of cell;

[0031] If the value of at least one type of cell in the detection result of the sample to be analyzed is not less than the preset threshold, control the cell image analysis device to photograph the smear of the sample to be analyzed under a second photographing condition different from the first photographing condition to obtain an image of the at least one type of cell;

[0032] Wherein, the photographing positions corresponding to the first photographing condition and the second photographing condition are different.

[0033] On the other hand, an embodiment of the present invention provides a sample analysis system, including:

[0034] A blood cell analyzer for detecting at least one sample to obtain the detection result of the at least one sample;

[0035] A control device for obtaining the detection result of the at least one sample;

[0036] A smear preparation device for preparing a smear of a sample to be analyzed by a cell image analysis device to obtain a smear of the sample to be analyzed;

[0037] A cell image analysis device for photographing and analyzing the smear of the sample to be analyzed to obtain the cell image and cell image analysis result of the sample to be analyzed;

[0038] The control device is further configured to select an analysis mode of the cell image analysis device according to at least one of the detection result of the sample to be analyzed and the sample information, and the shooting condition of the analysis mode is related to the detection result; the analysis mode includes at least one mode or a combination of at least two or more modes among a white blood cell analysis mode, a red blood cell analysis mode, and a platelet analysis mode;

[0039] The control device is further configured to control the cell image analysis device to shoot the smear of the sample to be analyzed according to the selected analysis mode.

[0040] On the other hand, an embodiment of the present invention provides a sample analysis system, including:

[0041] A blood cell analyzer for detecting at least one sample to obtain a detection result of the at least one sample;

[0042] A control device for obtaining the detection result of the at least one sample;

[0043] A smear preparation device for preparing a smear of a sample to be analyzed by a cell image analysis device to obtain a smear of each sample to be analyzed;

[0044] A cell image analysis device for shooting and analyzing the smear of the sample to be analyzed to obtain a cell image and a cell image analysis result of the sample to be analyzed;

[0045] The control device is further configured to:

[0046] If the value of at least one type of cell in the detection result of the sample to be analyzed is less than a preset threshold, control the cell image analysis device to shoot the smear under a first shooting condition to obtain an image of the at least one type of cell;

[0047] If the value of at least one type of cell in the detection result of the sample to be analyzed is not less than the preset threshold, control the cell image analysis device to shoot the smear of the sample under a second shooting condition different from the first shooting condition to obtain an image of the at least one type of cell;

[0048] The shooting ranges corresponding to the first shooting condition and the second shooting condition are different.

[0049] On the other hand, an embodiment of the present invention provides a sample analysis system, including:

[0050] A blood cell analyzer for detecting at least one sample to obtain a detection result of the at least one sample;

[0051] A control device for obtaining the detection result of the at least one sample;

[0052] A smear preparation device for preparing a smear of a sample to be analyzed by a cell image analysis device, so as to obtain a smear of the sample to be analyzed;

[0053] A cell image analysis device for photographing and analyzing the smear of the sample to be analyzed to obtain a cell image and a cell image analysis result of the sample to be analyzed;

[0054] The control device is further configured to:

[0055] If the detection result of the sample to be analyzed includes abnormal cells, adjust the number of cell image photographs according to the proportion of the abnormal cells.

[0056] On the other hand, an embodiment of the present invention provides a cell image analysis device, including:

[0057] A photographing device for photographing a smear of a sample to be analyzed;

[0058] A control device for obtaining the detection result of the sample to be analyzed detected by a blood cell analyzer;

[0059] The control device is further configured to:

[0060] If the value of at least one type of cell in the detection result of the sample to be analyzed is less than a preset threshold, control the photographing device to photograph the smear of the sample to be analyzed under a first photographing condition to obtain an image of the at least one type of cell;

[0061] If the value of at least one type of cell in the detection result of the sample to be analyzed is not less than the preset threshold, control the photographing device to photograph the smear of the sample to be analyzed under a second photographing condition different from the first photographing condition to obtain an image of the at least one type of cell;

[0062] At least one of the cell image photographing quantity, photographing range, photographing position, photographing objective lens magnification, and focusing range corresponding to the first photographing condition and the second photographing condition is different.

[0063] On the other hand, an embodiment of the present invention provides a blood cell analysis method, including:

[0064] Obtaining the detection result of the sample to be analyzed;

[0065] If the value of at least one type of cell in the detection result of the sample to be analyzed is less than a preset threshold, control the cell image analysis device to photograph the smear of the sample to be analyzed under a first photographing condition to obtain an image of the at least one type of cell;

[0066] If the value of at least one type of cell in the test result of the sample to be analyzed is not less than a preset threshold, control the cell image analysis device to capture the smear of the sample to be analyzed under a second shooting condition different from the first shooting condition, so as to obtain an image of the at least one type of cell;

[0067] Wherein, the number of cell images captured by the cell image analysis device under the first shooting condition is greater than the number of cell images captured under the second shooting condition.

[0068] On the other hand, an embodiment of the present invention provides a blood cell analysis method, including:

[0069] Obtain the test result of the sample to be analyzed;

[0070] If the value related to the cell volume in the value of at least one type of cell in the test result is less than a preset threshold, control the cell image analysis device to capture the smear of the sample to be analyzed under the first shooting condition, so as to obtain an image of the at least one type of cell;

[0071] If the value related to the cell volume in the value of at least one type of cell in the test result is not less than a preset threshold, control the cell image analysis device to capture the smear of the sample to be analyzed under a second shooting condition different from the first shooting condition, so as to obtain an image of the at least one type of cell.

[0072] On the other hand, an embodiment of the present invention provides a blood cell analysis method, including:

[0073] Obtain the test result of the sample to be analyzed;

[0074] If the platelet count value in the test result is less than a preset threshold, control the cell image analysis device to capture the smear of the sample to be analyzed under the first shooting condition, so as to obtain an image of the at least one type of cell;

[0075] If the platelet count value in the test result is not less than a preset threshold, control the cell image analysis device to capture the smear of the sample to be analyzed under a second shooting condition different from the first shooting condition, so as to obtain an image of the at least one type of cell;

[0076] Wherein, the shooting positions corresponding to the first shooting condition include the tail and / or edge of the smear; the shooting positions corresponding to the second shooting condition include the body part of the smear.

[0077] On the other hand, an embodiment of the present invention provides a blood cell analysis method, including:

[0078] Obtain the test result of the sample to be analyzed and the sample information of the sample to be analyzed;

[0079] Select an analysis mode of the cell image analysis device based on at least one of the detection result of the sample to be analyzed and the sample information of the sample to be analyzed. The analysis mode includes at least one mode or a combination of at least two modes among a white blood cell analysis mode, a red blood cell analysis mode, and a platelet analysis mode;

[0080] Control the cell image analysis device to take a picture of the smear of the sample to be analyzed according to the selected analysis mode.

[0081] On the other hand, an embodiment of the present invention provides a blood cell analysis method, including:

[0082] Obtain the detection result of the sample to be analyzed;

[0083] If the value of at least one type of cell in the detection result of the sample to be analyzed is less than a preset threshold, control the cell image analysis device to take a picture of the smear under a first shooting condition to obtain an image of at least one type of cell;

[0084] If the value of at least one type of cell in the detection result of the sample to be analyzed is not less than the preset threshold, control the cell image analysis device to take a picture of the smear of the sample under a second shooting condition different from the first shooting condition to obtain an image of at least one type of cell;

[0085] The shooting ranges corresponding to the first shooting condition and the second shooting condition are different.

[0086] On the other hand, an embodiment of the present invention provides a blood cell analysis method, including:

[0087] Obtain the detection result of the sample to be analyzed;

[0088] If the detection result of the sample to be analyzed includes abnormal cells, adjust the number of cell images taken according to the proportion of abnormal cells.

[0089] On the other hand, an embodiment of the present invention provides a blood cell analysis method, including:

[0090] Obtain the detection result of the sample analyzed by a blood cell analyzer;

[0091] Prepare a blood smear of the sample;

[0092] If the detection result of the sample includes infected red blood cells, control the cell image analysis device to take a picture of the area with a thicker blood film on the blood smear to detect whether there are malaria parasites; wherein, the area with a thicker blood film on the blood smear includes the body and the tail of the blood smear.

[0093] In another aspect, an embodiment of the present invention provides a storage medium, on which executable instructions are stored, configured to cause a processor to implement at least one of the above blood cell analysis methods when executing the executable instructions.

[0094] In an embodiment of the present invention, a sample analysis system includes: a blood cell analyzer, a smear preparation device, a cell image analysis device, and a control device. The control device can obtain the detection results of at least one sample from the blood cell analyzer. When there is a sample that needs to be analyzed by the cell image analysis device among the at least one sample, the control device can also control the cell image analysis device according to at least one cell value in the detection results of the sample to be analyzed. One control method is that if at least one cell value in the detection results of the sample to be analyzed is less than a preset threshold, the control device controls the cell image analysis device to take a picture of the smear of the sample to be analyzed under the first shooting condition; if at least one cell value in the detection results of the sample to be analyzed is not less than the preset threshold, the control device controls the cell image analysis device to take a picture of the smear of the sample to be analyzed under a second shooting condition different from the first shooting condition, where the number of cell images taken by the cell image analysis device under the first shooting condition is greater than the number of cell images taken under the second shooting condition, so that the cell image analysis device can automatically select a shooting condition matching the detection results according to different detection results of the sample to be analyzed for shooting, and thus can take and analyze cell images of the smear of the sample to be analyzed with a targeted shooting condition (such as shooting the abnormal part indicated by the detection results of the sample to be analyzed in a targeted manner), improving the processing efficiency and processing accuracy of the cell image analysis device, and overcoming the problems of low processing efficiency and low accuracy caused by using the same shooting condition for the sample to be analyzed currently. BRIEF DESCRIPTION OF THE DRAWINGS

[0095] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for describing the embodiments or the prior art. Obviously, the following drawings are some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained according to these drawings.

[0096] Figure 1 is an optional structural schematic diagram of a sample analysis system provided by an embodiment of the present invention;

[0097] Figure 2 is a schematic diagram of a smear provided by an embodiment of the present invention;

[0098] Figure 3 is an optional structural schematic diagram of the control device in the sample analysis system provided by an embodiment of the present invention;

[0099] Figure 4 And Figure 5 are alternative schematic structural diagrams of a cell image analysis device in a sample analysis system provided by an embodiment of the present invention;

[0100] Figure 6 is an alternative schematic structural diagram of another sample analysis system provided by an embodiment of the present invention;

[0101] Figure 7 is an alternative schematic structural diagram of a cell image analysis device provided by an embodiment of the present invention;

[0102] Figure 8 is an alternative flowchart of a blood cell analysis method provided by an embodiment of the present invention;

[0103] Figure 9 is an alternative flowchart of another blood cell analysis method provided by an embodiment of the present invention;

[0104] Figure 10 is an alternative flowchart of yet another blood cell analysis method provided by an embodiment of the present invention;

[0105] Figure 11 is an alternative flowchart of yet another blood cell analysis method provided by an embodiment of the present invention;

[0106] Figure 12 is an alternative flowchart of yet another blood cell analysis method provided by an embodiment of the present invention;

[0107] Figure 13 is an alternative flowchart of yet another blood cell analysis method provided by an embodiment of the present invention. Detailed implementation manners

[0108] In order to make the objectives, technical solutions, and advantages of the present invention clearer, the present invention will be further described in detail below with reference to the accompanying drawings. The present invention should not be construed as being limited to the provided embodiments. On the contrary, the content recorded in the embodiments of the present invention makes the present invention comprehensive and complete, and conveys the inventive concept of the embodiments of the present invention to those skilled in the art. Therefore, other embodiments obtained by those of ordinary skill in the art without creative efforts all fall within the scope of protection of the present invention.

[0109] It should be noted that in the embodiments of the present disclosure, the terms "include", "comprise" or any other variant thereof are intended to cover non-exclusive inclusion, such that a method or server including a series of elements not only includes the elements explicitly recited, but also includes other elements not explicitly listed, or further includes elements inherent to the implementation of the method or server. Without further limitation, an element defined by the statement "including one..." does not exclude the existence of additional related elements in the method or server including such element (for example, steps in the method or units in the server, where the unit may be a part of a circuit, a part of a processor, a part of a program or software, etc.).

[0110] For example, the sample analysis system and device provided in the embodiments of the present disclosure include a series of components, but the sample analysis system and device provided in the embodiments of the present disclosure are not limited to including the explicitly recited components. Similarly, the blood cell analysis method provided in the embodiments of the present disclosure includes a series of steps, but the blood cell analysis method provided in the embodiments of the present disclosure is not limited to the recited steps. It should be noted that in the following description, reference is made to "embodiments", which describe a subset of all possible embodiments. However, it can be understood that "embodiments" can be the same subset or different subsets of all possible embodiments and can be combined with each other without conflict.

[0111] Please refer to Figure 1 , which shows an optional structure of a sample analysis system provided in an embodiment of the present invention. Figure 1 The sample analysis system 100 shown may include: a blood cell analyzer 101, a control device 102, a smear preparation device 103, and a cell image analysis device 104.

[0112] The blood cell analyzer 101 is configured to detect at least one sample to obtain a detection result of the at least one sample.

[0113] The control device 102 is configured to obtain the detection result of the at least one sample.

[0114] The smear preparation device 103 is used to prepare a smear of a sample that needs to be analyzed by a cell image analysis device, so as to obtain a smear of the sample to be analyzed. In the embodiment of the present invention, the sample to be analyzed is a sample that has been detected by a blood cell analyzer and still needs to be analyzed by a cell image analysis device, and can also be called a sample to be re-examined; for a sample detected by a blood cell analyzer, if the detection result triggers a preset microscopic examination rule, it will be transported to the smear preparation device 103 for smear preparation, and then the cell image of the sample will be taken and analyzed by the cell image analysis device. In this way, some samples that need microscopic examination can be re-examined, which can improve the accuracy of the sample detection result and save the sample analysis time; or, all samples detected by the blood cell analyzer are transported to the smear preparation device 103 for smear preparation, and then the cell image of the sample is taken and analyzed by the cell image analysis device, so that all samples can be re-examined, making the test result more accurate and reliable.

[0115] The cell image analysis device 104 is used to take pictures and analyze the smear of the sample to be analyzed to obtain the cell image and cell image analysis result of the sample to be analyzed.

[0116] The control device 102 is further used to control the shooting of the smear of the sample to be analyzed by the cell image analysis device 104. The control of the control device 102 includes but is not limited to the following methods:

[0117] If blast cells appear in the detection result of the sample to be analyzed, increase the number of white blood cell images taken. For example, the control device 102 instructs the cell image analysis device 104 to increase the shooting area to obtain more white blood cell images. When blast cells do not appear, the number of white blood cell images taken is 100. When blast cells appear, the number of white blood cell images taken is 500, so as to increase the probability of blast cells being discovered and improve the detection sensitivity.

[0118] If the platelet count value in the detection result of the sample to be analyzed is less than a preset threshold, such as less than 20×10^9 / L, the control device 102 instructs the cell image analysis device 104 to take pictures of the tail of the smear to confirm whether platelet aggregation has occurred through the cell image of the tail. This can help the doctor confirm whether it is a real decrease in platelets or a decrease in platelets caused by platelet aggregation at this time, and help the doctor evaluate the bleeding tendency of the patient.

[0119] If the platelet count value is less than the preset threshold, the control device 102 can further instruct the cell image analysis device 104 to take pictures of the edge of the smear, and the platelet aggregation can also be judged.

[0120] If red blood cell fragments appear in the test results of the sample to be analyzed, the control device 102 instructs the cell image analysis device 104 to take cell images in the red blood cell analysis mode. The cell image analysis device 104 can also output the taken cell images (such as red blood cell images) and the proportion of red blood cell fragments for the doctor to judge whether there are really red blood cell fragments and confirm their proportion, and issue a report.

[0121] If the volume of red blood cells in the test results of the sample to be analyzed is less than the preset volume (microcytic red blood cells appear), such as the mean corpuscular volume MCV < 70 fL, the control device 102 instructs the cell image analysis device 104 to perform a small-area red blood cell scan on the smear and output the taken cell images for the doctor to judge whether there are really microcytic red blood cells (i.e., red blood cells with a volume less than the preset volume) based on the cell images. And the cell image analysis device 104 can further output the proportion of microcytic red blood cells.

[0122] If the sample to be analyzed is a sample from pediatrics and has no historical medical record, the control device 102 instructs the cell image analysis device 104 to select a simple mode that combines the white blood cell analysis mode, the red blood cell analysis mode, and the platelet analysis mode for shooting to meet the comprehensive reexamination needs of first-time patients at the lowest time cost.

[0123] If the result values of white blood cells, red blood cells, and platelets in the test results of the sample to be analyzed are all lower than the corresponding preset thresholds, such as the count value of white blood cells (WBC) is less than 4*10 9 / L, hemoglobin (HGB) is less than 100 g / L, and the count value of platelets is less than 100*10 9 / L, the control device 102 instructs the cell image analysis device 104 to select a simple mode that combines the white blood cell analysis mode, the red blood cell analysis mode, and the platelet analysis mode for shooting to meet the comprehensive reexamination needs of the sample to be analyzed at the lowest time cost.

[0124] If nucleated red blood cells (NRBCs) appear in the test results of the sample to be analyzed, the control device 102 instructs the cell image analysis device 104 to increase the number of white blood cell localization and captures. If the target number of white blood cells to be captured is set to 100, the normal process is to localize 1.2 times the target number of white blood cells under a low-power microscope (such as 10X), for example, localize 120 white blood cells under the low-power microscope, and then capture the white blood cells in the localized area through a high-power microscope (such as 100X) to obtain the target number of white blood cells. However, for samples with a relatively high proportion of NRBCs, there may be insufficient captured white blood cells. Therefore, the number of white blood cells localized under the low-power microscope can be adjusted according to the NRBC results. For example, when there are no nucleated red blood cells, the number of captured white blood cell images under the low-power objective lens is 120, and 100 white blood cell images can be obtained under the high-power objective lens. If nucleated red blood cells appear, especially when the number of nucleated red blood cells is relatively large (i.e., the sample to be analyzed is a sample with a high proportion of nucleated red blood cells), if 120 is still used under the low-power objective lens, it may not be possible to obtain 100 white blood cell images under the high-power objective lens. At this time, the number of captured white blood cell images under the low-power objective lens needs to be increased to meet the requirement for the number of white blood cell images under the high-power objective lens; for the test results of the sample to be analyzed where large platelets appear, that is, the volume of platelets is greater than the preset value, the method of increasing the number of captured white blood cell images under the low-power objective lens is also adopted.

[0125] If the count value of red blood cells in the test results of the sample to be analyzed is less than the preset threshold, the control device 102 instructs or controls the cell image analysis device 104 to expand the capture range (i.e., increase the capture area). For example, normally the cell image analysis device 104 can capture 1000 red blood cells in the set fixed area. However, if the count value of red blood cells is less than the preset threshold, using the previous capture range size may not capture 1000 red blood cells. Therefore, the capture range can be expanded to obtain sufficient red blood cells.

[0126] If the count value of white blood cells in the test results of the sample to be analyzed is less than the preset threshold, the capture range is controlled to be expanded. For example, based on capturing the body part of the smear, the cell image analysis device 104 extends the capture from the body part of the smear to the edge to capture the edge of the smear and expand the capture range to obtain the target number of white blood cell images.

[0127] If the test results of the sample to be analyzed indicate classification abnormalities, such as abnormal five-class percentages, the control device 102 instructs the cell image analysis device 104 to directly use a 40X objective lens, which can improve efficiency. If the test results of the sample to be analyzed include abnormal cells, such as blast cells, nucleated red blood cells (NRBCs), abnormal lymphocytes, etc., then a 100X lens is still selected for capture.

[0128] If the volume of a certain type of cell (such as white blood cells, red blood cells, or platelets) in the test result of the sample to be analyzed is less than the preset threshold, the control device 102 instructs the cell image analysis device 104 to select a smaller shooting depth of field to capture the cell image. If the volume of this type of cell is greater than the preset threshold, a larger shooting depth of field can be selected. The test results of the sample detected by the blood cell analyzer include the result values, histograms, scatter plots, etc. of each test item. The histogram can reflect the relationship between cell volume and cell quantity or proportion. For example, according to the FSC (Forward Scatter) in the white blood cell histogram, the cell size can be distinguished. The larger the value of the forward scatter light intensity, the larger the cell. In the embodiment of the present invention, according to the cell volume size, the control device 102 can control the cell image analysis device 104 to select different depths of field to capture cell images. For large-volume cells, capture cell images with a larger depth of field range and then fuse them. For small-volume cells, capture cell images with a smaller depth of field range.

[0129] If the test result of the sample to be analyzed indicates platelet aggregation, the control device 102 instructs the cell image analysis device 104 to capture the tail or edge of the smear.

[0130] If the count value of platelet PLT in the test result of the sample to be analyzed is high (such as the count value of PLT is greater than the set threshold), the control device 102 instructs the cell image analysis device 104 to capture a smaller area (i.e., reduce the shooting range), and then estimate the count value of PLT by the image method; if the count value of PLT is less than the set threshold, a larger area (i.e., expand the shooting range) can be captured to capture the target number of PLTs.

[0131] If the test result of the sample to be analyzed indicates red blood cell aggregation, the control device 102 instructs the cell image analysis device to capture the tail of the smear.

[0132] Select the number of cell images to be taken according to the proportion of abnormal cells in the test results of the sample to be analyzed. The higher the proportion of abnormal cells, the more cell images the cell image analysis device 104 takes. For example, the higher the proportion of nucleated red blood cells (NRBC), the more white blood cells the control device 102 instructs the cell image analysis device 104 to locate and photograph; the lower the proportion of NRBC, the fewer white blood cells to be located and photographed. For example, under normal circumstances, the target number of white blood cells to be photographed is 100. If there are no abnormal cells, the number of white blood cells to be located and photographed remains unchanged. If there are abnormal cells, the number of white blood cells to be located is adjusted based on the proportion of abnormal cells on the basis of the target number 100, and the number of white blood cells to be photographed is increased accordingly. For example, if the proportion of NRBC is 1%, the number of white blood cells to be located is adjusted to 150, and then the located white blood cells are photographed. If the proportion of NRBC is 2%, the number of white blood cells to be located is adjusted to 200, and then the located white blood cells are photographed. Among them, the cell image analysis device locates white blood cells through a low-power objective lens. The located white blood cells include white blood cells and suspected white blood cells (such as NRBC). If the number of located white blood cells is 100, the higher the proportion of NRBC, the fewer real white blood cells among the 100 located white blood cells (including suspected white blood cells). Therefore, the higher the proportion of NRBC, the more cells need to be located and photographed.

[0133] If the test results of the sample to be analyzed indicate a high proportion of abnormal cells, for example, the proportion of abnormal cells is higher than the preset proportion, the control device 102 instructs the cell image analysis device 104 to reduce the number of cell images taken, thus saving time. For example, the test results of a blood cell analyzer show that neutrophils are 95%. At this time, the cell image analysis device only needs to take 50 images to see the vast majority of neutrophils, and there is no need to take more cell images. For the sample analysis system shown above Figure 1 A detailed description will be given below.

[0134] The blood cell analyzer 101 is used to test at least one sample to obtain the test results of at least one sample. Among them, at least one sample can be a blood sample, a body fluid sample, or other samples that need to be tested for cell count. For example, the blood cell analyzer 101 can perform a complete blood count test on at least one blood sample and / or at least one body fluid sample respectively to test cells such as white blood cells (WBC), red blood cells (RBC), and platelets (PLT) in the sample, and obtain the test results of cells such as WBC, RBC, and PLT in the sample.

[0135] In this embodiment, after the blood cell analyzer 101 tests the sample, it outputs the test results of the sample. The test results of the sample can be at least one of the cell test parameters of at least one type of cell in the sample and the information on whether the cell test parameters of at least one type of cell are abnormal.

[0136] The control device 102 is configured to obtain the test results of at least one sample. The control device 102 can be communicatively connected to the blood cell analyzer 101. Through the communication connection method adopted by both, the control device 102 obtains the test results of the sample obtained by the blood cell analyzer. For example, if the control device 102 is connected to the blood cell analyzer 101 by a wired or wireless method, the control device 102 obtains the test results of at least one sample obtained by the blood cell analyzer through a wired transmission method or a wireless transmission method.

[0137] Since the control device 102 can obtain the test results of multiple samples respectively, and there may be differences between the test results of different samples, the control device 102 needs to establish a correspondence between the test results of the samples and the samples, so as to identify the test results through the sample information of the samples, and indicate the sample corresponding to the test results through the sample information. For example, the sample information of the sample includes at least one of the sample number, the subject to which the sample belongs, etc., so that the sample information can uniquely specify a sample.

[0138] The smear preparation device 103 is used to prepare a smear of the sample to be analyzed by the cell image analysis device, so as to obtain a smear of the sample to be analyzed. The smear is a substrate for smearing specimens. For example, it is a glass slide after evenly smearing the sample to be analyzed and staining the cells therein.

[0139] In this embodiment, the smear preparation device 103 obtains the smear of the sample to be analyzed through operations such as spreading and staining. However, it should be noted here that currently, after preparing the smear of the body fluid sample, a spreading operation needs to be added to spread out a specific-shaped area in the smear, such as spreading out a circular area. Regarding this characteristic of the smear of the body fluid sample, the smear preparation device 103 can include a first preparation device (such as a spreader) for preparing a smear of the blood sample and a second preparation device (such as a centrifugal spreader) for preparing a smear of the body fluid sample. When the smear preparation device obtains a sample to be analyzed, if the sample to be analyzed is a blood sample, the sample to be analyzed is conveyed to the first preparation device (such as a spreader); if the sample to be analyzed is a body fluid sample according to the situation, the sample to be analyzed is conveyed to the second preparation device (such as a centrifugal spreader).

[0140] For any sample to be analyzed, a corresponding relationship is established between the smear prepared by the smear preparation device 103 and the test result obtained by the blood cell analyzer 101 to indicate that the smear and the test result belong to the same sample to be analyzed. One way to establish the corresponding relationship between the two is to correspond the smear and the test result through the sample information (such as the sample number) of the sample to be analyzed. For example, a label area is set on the smear, and this label area is used to set the sample information. For example, the smear preparation device 103 can obtain the sample information from the blood cell analyzer 101 and set the sample information in the label area. For example, the smear preparation device 103 has the function of generating a two-dimensional code, displays the sample information in the form of a two-dimensional code, and prints the generated two-dimensional code in the label area.

[0141] The sample that needs to be analyzed by the cell image analysis device can be each sample detected by the blood cell analyzer 101, that is, each sample needs to be analyzed by the cell image analysis device after being detected by the blood cell analyzer 101. Each sample analyzed by the blood cell analyzer 101 is a sample to be analyzed. At this time, each sample also needs to be smeared by the smear preparation device 103. Although this method will consume a lot of time, the accuracy of the test results of the sample can be improved through sample reexamination.

[0142] Alternatively, the control device 102 selects the samples that need to be analyzed by the cell image analysis device according to the test results of the samples. These samples selected by the control device 102 are samples to be analyzed. One optional way for the control device 102 to select the samples that need to be reexamined according to the test results of the samples is to select the samples that need to be reexamined according to the test results of the samples and the preset reexamination conditions. When the test result of the sample meets the preset reexamination conditions, the control device 102 determines the sample to which the test result belongs as the sample to be analyzed and instructs the smear preparation device 103 to prepare a smear for the sample to be analyzed.

[0143] The preset reexamination conditions are used to indicate at least one of the following: the test result contains an abnormal result indicating that the sample is abnormal, the test result contains a specific type of cell parameter, the subject to which the test result belongs is a preset object of concern, and the sample corresponding to the test result comes from a specific department. The above specific type of cell parameter includes but is not limited to the parameter of white blood cells. The preset object of concern can be, but is not limited to, a patient with a white blood cell disease. The specific department can be, but is not limited to, the reproductive medicine department, etc. The specific type of cell parameter, the preset object of concern, and the specific department can be determined according to medical needs and are not limited in this embodiment. For example, the preset reexamination condition includes WBC < 2. If the count value of WBC in the test result of a certain sample after being detected by the blood cell analyzer 101 is 1, the unit of the count value of WBC is 10 9 / L, the test result of the sample triggers a preset recheck condition, and it is a sample that needs to be rechecked by the cell image analysis device 104.

[0144] The cell image analysis device 104 is used to take pictures and analyze the smear of the sample to be analyzed to obtain the cell image and the cell image analysis result of the sample to be analyzed. In particular, it is used to identify and locate abnormal cells in the smear, and then take pictures and analyze the identified and located abnormal cells.

[0145] When the cell image analysis device 104 takes pictures of the smear of the sample to be analyzed, certain shooting conditions need to be adopted. In this embodiment, the shooting conditions are determined by the control device 102. The way the control device 102 determines the shooting conditions is as follows: The control device 102 selects the shooting conditions according to the relationship between the value of at least one type of cell in the monitoring result and the preset threshold. The selection process is as follows:

[0146] If the value of at least one type of cell in the test result of the sample to be analyzed is less than the preset threshold, the control device controls the cell image analysis device to take pictures of the smear of the sample to be analyzed using the first shooting condition to obtain the images of at least one type of cell; if the value of at least one type of cell in the test result of the sample to be analyzed is not less than the preset threshold, the control device controls the cell image analysis device to take pictures of the smear of the sample to be analyzed using a second shooting condition different from the first shooting condition to obtain the images of at least one type of cell. Thus, the control device 102 selects the matching shooting condition from the first shooting condition and the second shooting condition according to the size relationship between the value of at least one type of cell and the preset threshold.

[0147] The value of at least one type of cell based on which the control device 102 selects the shooting conditions can be: the value of the cell that affects the shooting and analysis of the cell image analysis device. Taking white blood cells as an example, a preset number of white blood cell images need to be taken during the analysis process. If not enough are taken, they will be taken again or it will affect the analysis result of white blood cells. Therefore, the number of white blood cells in the test result of the sample to be analyzed will affect the shooting and analysis of the cell image analysis device. According to the different numbers of white blood cells, this embodiment needs to adopt matching shooting conditions. Based on this, one way of the value of at least one type of cell is: the value of at least one type of cell includes at least one of the number, proportion, or volume of at least one type of cell.

[0148] In one embodiment, the test results of the blood cell analyzer 101 after testing a blood sample generally include the result values of the following test items or test parameters: red blood cell count (RBC), hematocrit (HCT), mean corpuscular volume (MCV), red blood cell distribution width, hemoglobin concentration (HGB), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), white blood cell count (WBC), monocyte count (MONO), monocyte ratio (MONO%), neutrophil count (NEUT), neutrophil ratio (NEUT%), lymphocyte count (LY), lymphocyte ratio (LY%), platelet count (PLT), platelet volume distribution width (PDW), mean platelet volume (MPV), large platelet ratio (P-LCR), plateletcrit (PCT), etc. The control device 102 can select shooting conditions according to the result values of these test items or test parameters of the sample to be analyzed, so that the cell image analysis device 104 can shoot the cells on the sample smear according to the corresponding shooting conditions. The test results of the blood cell analyzer 101 after testing a blood sample may also include histograms, scatter plots, etc. The cell volume, quantity, ratio or abnormal cell information, etc. can also be obtained or identified according to the histograms and scatter plots.

[0149] Taking a kind of cell as an example, the quantity of this cell represents the count value of this kind of cell in the test results of the sample to be analyzed. The count value of a certain kind of cell is the quantity of this kind of cell per unit volume. When testing the sample with a blood cell analyzer, those with a similar morphology to this cell may also be regarded as this type of cell. Therefore, the quantity of this cell represents the total number of this kind of cell and the suspected cells in the sample to be analyzed.

[0150] The ratio of this cell represents the proportion of the total number of this kind of cell in the sample to be analyzed to the total number of all cells in the sample to be analyzed. If the blood cell analyzer can detect the number of suspected cells from the total number of this kind of cell, then there are two ratios for this cell: one is the proportion of the total number of this kind of cell (including the suspected ones) to the total number of all cells in the sample to be analyzed; the other is the proportion of the number of non-suspected cells of this kind of cell to the total number of this kind of cell.

[0151] The volume of this cell represents the size of this kind of cell in the sample to be analyzed. In the actual detection process, a sample to be analyzed may include multiple cells of this type. Then the volume of this cell can be represented by at least one of the average volume of this cell, the volume range of this cell, the average volume and volume range of different levels of this cell in the sample to be analyzed. The levels of cells can be divided by volume.

[0152] The above describes the number, proportion, and volume of cells taking one type of cell as an example. However, the protection scope of this embodiment is not limited by the above description, and other descriptions of the number, proportion, and volume of cells can also be applied to this embodiment.

[0153] At least one cell value based on which the control device 102 selects the shooting conditions may also be: the value of a specific type of cell concerned during the analysis. For example, if white blood cells, red blood cells, etc. need to be concerned during the analysis, at least one cell value includes at least one of the count values of white blood cells, red blood cells, and platelets. White blood cells, red blood cells, and platelets are specific types of cells.

[0154] The corresponding first shooting condition and second shooting condition indicate the way the cell image analysis device shoots the smear of the sample to be analyzed, such as indicating the shooting position of the sample to be analyzed (i.e., which position of the smear to shoot) and the shooting objective lens (i.e., the objective lens used during shooting). In this embodiment, the difference between the first shooting condition and the second shooting condition refers to the different number of cell images captured by the cell image analysis device. For example, the number of cell images captured by the cell image analysis device under the first shooting condition is greater than the number of cell images captured under the second shooting condition.

[0155] That is, if at least one cell value in the test result of the sample to be analyzed is less than the preset threshold, the cell image analysis device is controlled to capture a larger number of cell images; if at least one cell value in the test result of the sample to be analyzed is not less than the preset threshold, the cell image analysis device is controlled to capture a smaller number of cell images. The number of cell images captured under the first shooting condition and the second shooting condition can be determined according to the re-inspection requirements of this type of cell, and this embodiment does not limit this. For example, when the count value of white blood cells is lower than the preset threshold, 150 white blood cell images are captured under the first shooting condition; when the count value of white blood cells is not less than the preset threshold, 100 white blood cell images are captured under the second shooting condition.

[0156] The number of cell images captured under the first shooting condition (referred to as the first number) and the number of cell images captured under the second shooting condition (referred to as the second number) can be set according to the number of cell images set by the cell image analysis device (referred to as the initial number). For example, the first number is adjusted upward based on the initial number, that is, the first number is greater than the initial number, the second number is the same as the initial number or adjusted downward based on the initial number, that is, the second number is less than the initial number; or the first number is the same as the initial number, while the second number is less than the initial number. This embodiment does not limit how much to adjust upward and downward. The cell image analysis device can capture different types of cells, and the initial numbers of different types of cells are different. Therefore, when the control device 102 controls the cell image analysis device to capture images, it needs to set the first number and the second number with reference to the cells to be captured currently.

[0157] Taking red blood cells (RBCs) as an example, a certain number of RBC images need to be captured during reexamination, such as 1000 RBC images. The cell image analysis device believes that after obtaining a certain number of 1.2-fold images (such as 1200 RBC images) under a low-power objective lens, 1000 RBC images can be obtained under a high-power objective lens. However, when the count value of RBCs in the test result is less than the preset threshold, 1000 RBC images cannot be obtained by capturing 1.2-fold images. At this time, it is regarded that the number of identified and located cells is insufficient. In this case, the control device 102 of this embodiment will increase the RBC images captured by the cell image analysis device, that is, control the cell image analysis device to capture RBC images using the number of cell images under the first shooting condition. The number of cell images under the first shooting condition is greater than the number of cell images set by the cell image analysis device. Similarly, when the count value of RBCs in the test result is not less than the preset threshold and 1000 or more RBC images can be obtained by capturing 1.2-fold images, the control device 102 of this embodiment will maintain or reduce the RBC images captured by the cell image analysis device in this case, that is, control the cell image analysis device to capture RBC images using the number of cell images under the second shooting condition. The number of cell images under the second shooting condition is not greater than the number of cell images set by the cell image analysis device, so that the number of cell images captured by the cell image analysis device can be controlled according to different test results.

[0158] When the cell image analysis device takes cell images of the sample to be analyzed, it will select a shooting range. The size of this shooting range indicates the shooting area when the cell image analysis device takes pictures, which corresponds to an area on the smear, and the area corresponding to this shooting range can be a fixed area or a variable area (variable means different areas are shot at different times). When the value of the cell is less than the preset threshold, the cell image analysis device will also have a problem of insufficient recognition and positioning of cells when taking pictures of this shooting range. At this time, the control device 102 can expand this shooting range (that is, the corresponding shooting area expands) to take more cell images. Therefore, in this embodiment, the control device 102 can adjust the number of cell images taken by controlling the size of the shooting range.

[0159] In the embodiment of the present invention, the sample analysis system includes: a blood cell analyzer, a smear preparation device, a cell image analysis device, and a control device. The control device can obtain the detection results of at least one sample from the blood cell analyzer. When there is a sample that needs to be analyzed by the cell image analysis device among the at least one sample, the control device can also control the cell image analysis device according to at least one cell value in the detection results of the sample to be analyzed. One control method is that if at least one cell value in the detection results of the sample to be analyzed is less than the preset threshold, then control the cell image analysis device to take pictures of the smear of the sample to be analyzed under the first shooting condition; if at least one cell value in the detection results of the sample to be analyzed is not less than the preset threshold, then control the cell image analysis device to take pictures of the smear of the sample to be analyzed under the second shooting condition different from the first shooting condition, where the number of cell images taken by the cell image analysis device under the first shooting condition is greater than the number of cell images taken under the second shooting condition, so that the cell image analysis device can automatically select a shooting condition matching the detection result according to different detection results of the sample to be analyzed for shooting, so as to be able to take and analyze cell images of the smear of the sample to be analyzed with a targeted shooting condition (such as shooting the abnormal part indicated by the detection result of the sample to be analyzed in a targeted manner), improving the processing efficiency and processing accuracy of the cell image analysis device, and overcoming the problems of low processing efficiency and low accuracy caused by using the same shooting condition for the sample to be analyzed currently.

[0160] The number of cell images under the first shooting condition used when at least one cell value is less than the preset threshold is greater than the number of cell images under the second shooting condition. Although this will increase the shooting duration of the cell image analysis device in this way, the cell image analysis device can obtain more cell images and analyze more cell images, thereby improving the accuracy of the analysis.

[0161] In view of the above Figure 1In the sample analysis system shown, the first shooting condition and the second shooting condition are different in at least one of the size of the shooting range and the shooting position corresponding to the first shooting condition, except for the number of cell images, compared with the second shooting condition. That is, at least one of the number of cell images, the size of the shooting range, and the shooting position corresponding to the first shooting condition and the second shooting condition is different.

[0162] For example, the shooting range of the smear by the cell analysis device under the first shooting condition is larger than that under the second shooting condition. For example, the shooting range is expanded under the first shooting condition to capture more cell images.

[0163] The size of the shooting range under the first shooting condition (referred to as the first range) and the size of the shooting range under the second shooting condition (referred to as the second range) can be set according to the shooting range set by the cell image analysis device (referred to as the initial range). For example, the first range is adjusted upward based on the initial range, that is, the first range is larger than the initial range, and the second range is the same as the initial range or adjusted downward based on the initial range, that is, the second range is smaller than the initial range; or the first range is the same as the initial range, and the second range is smaller than the initial range; the cell image analysis device can capture different types of cells, and the initial ranges of different types of cells are different. Therefore, when the control device 102 controls the cell image analysis device to capture, it needs to set the first range and the second range with reference to the type of cells to be captured currently. Or the control device first sets one of the first range and the second range, and the other is set according to the relationship between the first range and the second range. For example, the second range is set first, and the first range is set by expanding the second range. The specific amount of expansion is not limited in this embodiment.

[0164] When the cell image analysis device captures using the sizes of the shooting ranges under the first shooting condition and the second shooting condition, the shooting positions covered by the shooting ranges of the first shooting condition and the second shooting condition can be different to obtain cell images at different positions.

[0165] In addition to the above, the shooting positions of the first shooting condition and the second shooting condition can be different. The shooting position represents the position when the cell image analysis device captures the smear, and it can be any position on the smear. For example, Figure 2 For a smear shown, in the shooting direction of the cell image analysis device from the head of the smear to the tail in sequence, the positions on the smear include: the head, the tail, the body, and the edge. The head is the position adjacent to the label area on the smear, the tail is the position far from the label area, the edge is the area of the remaining two sides of the smear except for the two sides of the head and the tail, and the body is the area between the head and the tail on the smear and excluding the edge. Or for the head and the tail, it can be determined according to the shape of the smear. For example, Figure 2The head of the smear shown is rectangular, and the tail of the smear is triangular.

[0166] For the head, tail, and edge of the smear, the area they occupy on the smear can be determined according to the analysis requirements, which will not be described in this embodiment. For a smear, the smear can also correspond to a two-dimensional XY coordinate system. The X direction is the direction extending from the body part to the edge, and the Y direction is the direction extending from the body part to the head and the tail, as Figure 2 shown is a two-dimensional XY coordinate system corresponding to a smear.

[0167] The control device 102 selects a matching shooting position according to the relationship between the value of at least one cell in the detection result and a preset threshold. That is to say, the shooting position of the smear by the cell image analysis device under the first shooting condition is different from the shooting position of the smear under the second shooting condition. The difference in the shooting position can be that the first shooting condition and the second shooting condition respectively shoot different positions. For example, the first shooting condition can shoot the tail of the smear, and the second shooting condition can shoot the body part of the smear; or the difference in the shooting position can be that the shooting position of one shooting condition in the first shooting condition and the second shooting condition includes the shooting position of the other shooting condition. For example, the shooting position of the first shooting condition includes the shooting position of the second shooting condition.

[0168] Taking white blood cells (WBC) as an example, when the cell image analysis device shoots the body part of the smear, if the value of WBC (such as the count value) is less than the preset threshold, there may be a problem of insufficient cells when shooting the body part of the smear. At this time, the control device 102 instructs or controls the cell image analysis device 104 to adjust the shooting position, extending the shooting position from the body part to the edge to shoot the body part and the edge simultaneously, and the shooting range is also enlarged through the extension.

[0169] At least one type of cell referred to by the above control device 102 includes platelets (PLT). The control device 102 can select a shooting condition according to the relationship between the count value of platelets and the corresponding preset threshold. The selected shooting condition indicates the shooting position: The control device 102 is used to control the cell image analysis device to adopt the first shooting condition if the count value of platelets in the detection result of the sample to be analyzed is less than the corresponding preset threshold, or to control the cell image analysis device to adopt the second shooting condition if the count value of platelets in the detection result of the sample to be analyzed is not less than the corresponding preset threshold.

[0170] Among them, the shooting position of the smear by the cell image analysis device under the first shooting condition includes the tail and / or edge of the smear, and the shooting position of the smear under the second shooting condition includes the body part of the smear.

[0171] The preset threshold corresponding to platelets can be determined according to the analysis requirements. For example, the preset threshold corresponding to platelets is but not limited to PLT = 20 * 10 9 / L. If the counted value of platelets is less than this preset threshold, the cell image analysis device needs to take pictures of the tail and / or edge of the smear. The reason for taking pictures in this way is that: when the counted value of platelets is less than the preset threshold, it may be that platelet aggregation occurs in the sample to be analyzed. By taking pictures of the tail and / or edge to obtain the cell images of the corresponding area, and then analyzing the cell images of the tail and / or edge to analyze whether the decrease in the counted value of platelets (i.e., less than the preset threshold) is caused by platelet aggregation.

[0172] Through the above technical solution, the control device 102 can control the shooting position of the cell image analysis device according to the counted value of platelets. Especially when the counted value of platelets is less than the corresponding preset threshold, controlling to take pictures at at least one of the tail and the edge can also analyze whether platelet aggregation occurs.

[0173] The following takes Table 1 as an example to elaborate Figure 1 For the sample analysis system shown, when the value of at least one cell is less than the corresponding preset threshold, the control of the number of cell images taken by the cell image analysis device, the shooting range, and the shooting position is described. Here, the low value in Table 1 means less than the preset threshold.

[0174] Table 1 Shooting conditions of the cell image analysis device

[0175] Serial number Cell value Shooting conditions 1 Low RBC value Increase the number of RBC image captures / capture range 2 Low WBC value Increase the number of WBC image captures / capture range / extended capture position 3 Low PLT value Increase the number of PLT image captures / capture the tail and / or edge

[0176] As can be seen from Table 1 above, the control device in the sample analysis system can, according to the relationship between the values of different cells and the preset threshold, select and match the appropriate shooting conditions to control the shooting of the cell image analysis device, so that the cell image analysis device can obtain cell images matching the detection results for analysis, improving the processing efficiency and processing accuracy of the cell image analysis device.

[0177] In another embodiment, for the Figure 1 sample analysis system shown, it includes:

[0178] A blood cell analyzer 101 for detecting at least one sample to obtain the detection results of at least one sample.

[0179] A control device 102 for obtaining the detection results of at least one sample.

[0180] A smear preparation device 103 for preparing a smear of the sample to be analyzed by the cell image analysis device to obtain a smear of the sample to be analyzed.

[0181] The cell image analysis device 104 is used to photograph and analyze a smear of a sample to be analyzed to obtain a cell image of the sample to be analyzed and a cell image analysis result.

[0182] The control device 102 is further configured to: if the value of at least one type of cell in the detection result of the sample to be analyzed is less than a preset threshold, control the cell image analysis device to photograph the smear of the sample to be analyzed under a first photographing condition to obtain an image of at least one type of cell; if the value of at least one type of cell in the detection result of the sample to be analyzed is not less than the preset threshold, control the cell image analysis device to photograph the smear of the sample to be analyzed under a second photographing condition different from the first photographing condition to obtain an image of at least one type of cell; wherein the value of at least one type of cell includes a value related to the cell volume.

[0183] In this embodiment, different photographing conditions can be selected according to the cell volume. Specifically, if the value related to the cell volume is less than the preset threshold, control the cell image analysis device to photograph the smear of the sample to be analyzed under the first photographing condition; if the value related to the cell volume is not less than the preset threshold, control the cell image analysis device to photograph the smear of the sample to be analyzed under the second photographing condition. The value related to the cell volume can be, for example, the volumes of WBC, RBC, and PLT, etc. If the value related to the cell volume in the detection result of the sample to be analyzed is less than the preset threshold, control the cell image analysis device to photograph under the first photographing condition; if the value related to the cell volume in the detection result of the sample to be analyzed is not less than the preset threshold, control the cell image analysis device to photograph under the second photographing condition.

[0184] The first photographing condition and the second photographing condition adopted by the cell image analysis device correspond to different focusing ranges. The focusing range refers to the front and back distance range of the object to be photographed (in this embodiment, the object to be photographed is the smear of the sample to be analyzed) measured for the cell image analysis device to obtain a clear cell image. The fact that the first photographing condition and the second photographing condition correspond to different focusing ranges can be that: the focusing range corresponding to the second photographing condition is larger than the focusing range corresponding to the first photographing condition. For example, when photographing small cells (the value related to the cell volume is less than the preset threshold), a smaller focusing range is used, and when photographing large cells (the value related to the cell volume is greater than the preset threshold), a larger focusing range is used. Using a larger focusing range for photographing can ensure the photographing clarity of large cells, and using a smaller focusing range for photographing small cells can not only ensure clarity but also save photographing time.

[0185] When the cell image analysis device photographs using the focusing range corresponding to the second photographing condition, the cell image analysis device can photograph multiple cell images at different depth-of-field depths, and then use an image fusion algorithm to fuse all the photographed cell images to obtain a single cell image.

[0186] In this embodiment, the above-mentioned Figure 1 The sample analysis system shown can select the shooting conditions of the cell image analysis device according to the relationship between the value related to the cell volume and the preset threshold. Thus, according to the value related to the cell volume in the detection result, the matching shooting conditions are selected, enabling the cell image analysis device to obtain the cell images matching the detection result for analysis, improving the processing efficiency and accuracy of the cell image analysis device.

[0187] In another embodiment, as Figure 1 The sample analysis system shown includes:

[0188] A blood cell analyzer 101 for detecting at least one sample to obtain the detection result of at least one sample.

[0189] A control device 102 for obtaining the detection result of at least one sample.

[0190] A smear preparation device 103 for preparing a smear of the sample to be analyzed by the cell image analysis device to obtain a smear of the sample to be analyzed.

[0191] A cell image analysis device 104 for photographing and analyzing the smear of the sample to be analyzed to obtain the cell image and the cell image analysis result of the sample to be analyzed.

[0192] The control device 102 is further configured to: if at least one cell value in the detection result of the sample to be analyzed is less than the preset threshold, control the cell image analysis device to photograph the smear of the sample to be analyzed using the first shooting condition to obtain the images of at least one cell; if at least one cell value in the detection result of the sample to be analyzed is not less than the preset threshold, control the cell image analysis device to photograph the smear of the sample to be analyzed using a second shooting condition different from the first shooting condition to obtain the images of at least one cell.

[0193] The shooting positions corresponding to the first shooting condition and the second shooting condition are different. The shooting positions include but are not limited to: the tail of the smear, the head of the smear, the body of the smear, and the edge of the smear. The first shooting condition and the second shooting condition can select one shooting position from these shooting positions. Further, these shooting positions may be a region of the smear. For example, the body of the smear is a region, then the first shooting condition and the second shooting condition can select different positions in the same region.

[0194] In this embodiment, the value of at least one cell can refer to the above relevant description. If the value of at least one cell includes the platelet count value, the process of the control device 102 selecting the shooting conditions is as follows:

[0195] If the platelet count value is less than the preset threshold, control the cell image analysis device to capture the smear of the sample to be analyzed under the first shooting condition; if the platelet count value is not less than the preset threshold, control the cell image analysis device to capture the smear of the sample to be analyzed under the second shooting condition.

[0196] The shooting positions corresponding to the first shooting condition include the tail and / or the edge of the smear. For example, the first shooting condition takes at least one of the tail and the edge of the smear as the shooting position; the shooting positions corresponding to the second shooting condition include the body part of the smear. The reason for taking at least one of the tail and the edge of the smear as the shooting position under the first shooting condition is as follows: When the platelet count value is less than the preset threshold, it may be that platelet aggregation occurs in the sample to be analyzed. By capturing the cell images of the corresponding areas at the tail and / or the edge, and then analyzing the cell images at the tail and / or the edge to determine whether the decrease in the platelet count value (i.e., less than the preset threshold) is caused by platelet aggregation. If the platelet count value is not less than the preset threshold, it indicates that platelet aggregation may not occur in the sample to be analyzed. At this time, the cell image analysis device can normally capture the body part of the smear. For the descriptions of the tail, the edge, and the body part, please refer to the above Figure 2 description.

[0197] Through the sample analysis system described in this embodiment, the control device can select the shooting position when the cell image analysis device captures the smear according to the relationship between the value of at least one type of cell in the detection result and the preset threshold, so as to select a shooting position that matches the value of at least one type of cell for shooting. In addition, for platelets, the matching shooting position can be selected according to the relationship between the platelet count value and the preset threshold, so as to determine whether platelet aggregation occurs in the sample to be analyzed by capturing the cell images at the tail and / or the edge when the platelet count value decreases.

[0198] In another embodiment, as Figure 1 shown in the sample analysis system, it includes:

[0199] A blood cell analyzer 101 for detecting at least one sample to obtain the detection result of at least one sample.

[0200] A control device 102 for obtaining the detection result of at least one sample.

[0201] A smear preparation device 103 for preparing a smear of the sample to be analyzed by the cell image analysis device to obtain the smear of the sample to be analyzed.

[0202] A cell image analysis device 104 for capturing and analyzing the smear of the sample to be analyzed to obtain the cell image and the cell image analysis result of the sample to be analyzed.

[0203] The control device 102 is further configured to select an analysis mode of the cell image analysis device according to at least one of the detection result of the sample to be analyzed and the sample information, and the analysis mode includes at least one mode or a combination of at least two modes among a white blood cell analysis mode, a red blood cell analysis mode, and a platelet analysis mode.

[0204] The control device 102 is further configured to select shooting conditions according to the detection result of the sample to be analyzed.

[0205] The control device 102 is further configured to control the cell image analysis device to photograph the smear of the sample to be analyzed according to the selected shooting conditions in the selected analysis mode.

[0206] The difference between the sample analysis system in this embodiment and the above embodiment is that: in this embodiment, the control device 102 of the sample analysis system needs to select the analysis mode and shooting conditions of the cell image analysis device, and then control the cell image analysis device according to the selected analysis mode and shooting conditions. When the control device 102 selects the shooting conditions, it is still based on the detection result of the sample to be analyzed, but the selection of the analysis mode is based on at least one of the detection result of the sample to be analyzed and the sample information, and the analysis mode can select at least one mode or a combination of at least two modes from the white blood cell analysis mode, the red blood cell analysis mode, and the platelet analysis mode as the analysis mode of the cell image analysis device, where the combination of at least two modes means selecting at least two modes from the white blood cell analysis mode, the red blood cell analysis mode, and the platelet analysis mode as the analysis mode of the cell image analysis device, so that the cell image analysis device can call the selected at least two modes to perform shooting and analysis in the selected at least two modes.

[0207] In this embodiment, the blood cell analyzer 101, the smear preparation device 103, and the cell image analysis device 104 can all obtain the sample information of the sample to be analyzed, and the corresponding control device 102 can obtain the sample information of the sample to be analyzed from at least one of the blood cell analyzer 101, the smear preparation device 103, and the cell image analysis device 104. For the description of the sample information of the sample to be analyzed, please refer to the above system embodiment, and this embodiment will not elaborate further.

[0208] In this embodiment, the control device 102 can select the analysis mode and shooting conditions of the cell image analysis device. Thus, the control device 102 of the sample analysis system can separately select the analysis mode and shooting conditions of the cell image analysis device, control the cell image analysis device to shoot the smear under the analysis mode matching at least one of the detection result and the sample information, and adopt the shooting conditions matching the detection result, so as to realize the automatic selection of the analysis mode and shooting conditions, and improve the processing efficiency of the cell image analysis device. Moreover, the analysis mode and shooting conditions are selectively determined according to the situation of the sample to be analyzed, so that the cell image analysis device works under the matching analysis mode and shooting conditions, thereby improving the processing efficiency and accuracy of the cell image analysis device.

[0209] Among them, the shooting conditions selected by the control device 102 are related to at least one of the number of cell images taken (i.e., the above-mentioned number of cell images), the size of the shooting range, the shooting position, the shooting objective lens magnification, and the focusing range, so as to instruct the shooting of the cell image analysis device from these aspects.

[0210] The shooting objective lens magnification indicates the objective lens used by the cell image analysis device when shooting the smear. For example, the shooting objective lens magnification includes but is not limited to at least one of a 10x objective lens, a 40x objective lens, and a 100x objective lens. For the description of the number of cell images taken, the shooting range, the shooting position, and the focusing range, please refer to the above system embodiment, and will also be described in combination with the selected analysis mode in this embodiment.

[0211] In this embodiment, one way for the control device 102 to select the shooting conditions is that the control device selects the shooting conditions according to at least one cell value in the detection result of the sample to be analyzed, and the at least one cell value includes at least one of the number, proportion, and volume of this type of cell.

[0212] For example, the control device selects the shooting conditions according to the relationship between at least one cell value and the corresponding preset threshold. For example, if at least one cell value in the detection result of the sample to be analyzed is less than the preset threshold, the first shooting condition is selected; if at least one cell value in the detection result of the sample to be analyzed is not less than the preset threshold, the second shooting condition different from the first shooting condition is selected.

[0213] The number of cell images captured under the first shooting condition is greater than the number of cell images captured under the second shooting condition, so that more cell images can be captured when the value of at least one type of cell (such as the count value) decreases. Although this method will increase the shooting duration of the cell image analysis device, the number of acquired cell images increases, so that more cell images can be analyzed, improving the accuracy. Or the number of cell images captured under the first shooting condition is less than the number of cell images captured under the second shooting condition, so as to reduce the number of cell images captured when the value of at least one type of cell (such as the count value) decreases, thereby reducing the shooting duration. However, in this way, the number of cell images acquired by the cell image analysis device will also decrease, resulting in fewer cell images that the cell image analysis device can use for analysis and reducing the accuracy.

[0214] In addition to the difference in the number of cell images captured, the first shooting condition and the second shooting condition can also have other differences. For example, the shooting range of the smear by the cell image analysis device under the first shooting condition is greater than that under the second shooting condition; or the shooting position of the smear by the cell image analysis device under the first shooting condition is different from that under the second shooting condition. For specific details, please refer to the description in the above system embodiment.

[0215] The analysis modes and related shooting conditions matching the three types of cells, namely white blood cells, red blood cells, and platelets, are described below:

[0216] White blood cells

[0217] If the test result of the sample to be analyzed includes abnormal information related to white blood cells, the control device 102 selects the white blood cell analysis mode or a combined mode including the white blood cell analysis mode. That is, the control device can only select the white blood cell analysis mode as the analysis mode of the cell image analysis device, or in addition to selecting the white blood cell analysis mode, at least one of the red blood cell analysis mode and the platelet analysis mode is selected from them. Although this method of selecting at least two modes will increase the processing duration of the cell image analysis device, it will increase the types of cells analyzed by the cell image analysis device and enrich the analysis results.

[0218] In this embodiment, the abnormal information related to white blood cells may include, but is not limited to: the count value of white blood cells deviates from the normal range, or abnormal cells related to white blood cells, etc. Among them, the count value of white blood cells lower than the normal range indicates that the number of white blood cells in the sample to be analyzed decreases, and the count value of white blood cells higher than the normal range indicates that the number of white blood cells in the sample to be analyzed increases; the abnormal cells related to white blood cells include, but are not limited to, primitive / immature cells (blast cells), immature granulocytes, abnormal lymphocytes, nucleated red blood cells, etc.

[0219] In an embodiment of the present invention, if the detection result of a sample includes the above-mentioned abnormal information related to white blood cells, a white blood cell analysis mode or a combined mode including the white blood cell analysis mode is selected. In the white blood cell analysis mode, the cell image analysis device can capture a target number of white blood cells, so as to further analyze the white blood cell-related information of the sample. In the combined mode, the shooting conditions of the white blood cell analysis mode are related to the detection result of white blood cells, and the shooting conditions of other analysis modes are related to the detection results of other cells. If the detection results of other cells are normal, the shooting conditions of other cell analysis modes are different from those when the detection results of other cells are abnormal.

[0220] In addition to being able to select an analysis mode according to the above-mentioned abnormal information, the above-mentioned abnormal information related to white blood cells will affect the white blood cell shooting and analysis results of the cell image analysis device. Therefore, more specific shooting conditions can also be further selected based on the above-mentioned abnormal information. For example, if the white blood cell analysis mode is selected, if the abnormal information related to white blood cells is that the count value of white blood cells is lower than the first preset threshold or abnormal cells related to white blood cells, the first shooting condition is used for shooting; if the abnormal information related to white blood cells is that the count value of white blood cells is not lower than (i.e., not less than) the first preset threshold or there are no abnormal cells related to white blood cells, the second shooting condition is used for shooting.

[0221] The number of white blood cell images captured under the first shooting condition is greater than the number of white blood cell images captured under the second shooting condition. Thus, when the count value of white blood cells decreases or abnormal cells related to white blood cells appear, the number of white blood cell images captured is increased. The number of white blood cell images captured refers to the number of cell images of white blood cells captured by the cell image analysis device, and the description thereof can be referred to the relevant description in the above system embodiment. The following illustrates the shooting conditions under abnormal information related to white blood cells from different examples:

[0222] If the detection result of the sample to be analyzed indicates the presence of blast cells, if the cell image analysis device continues to capture white blood cell images with the number of white blood cell images captured when there are no blast cells, there will be a situation where the number of white blood cells is insufficient and blast cells are not easily found. At this time, the control device 102 controls the cell image analysis device to capture white blood cell images with the number of white blood cell images captured under the first shooting condition, so as to increase the number of white blood cell images captured relative to when there are no blast cells. For example, if the number of white blood cell images captured when there are no blast cells is 100, then the number of white blood cell images captured when there are blast cells is 200. By increasing the number of white blood cell images captured, the probability of finding blast cells is increased, and the analysis sensitivity is improved.

[0223] There are no nucleated red blood cells in normal samples, or rather, the cell proportion of nucleated red blood cells (also known as cell occupancy) is a preset proportion (such as 0). For the normal sample cell image analysis device, a target number is set, which is the number of white blood cells that need to be photographed under a high-power objective lens (such as a 100x objective lens). Therefore, for normal samples, if the target number of white blood cells is identified and located under a low-power objective lens, the images of the target number of white blood cells can also be photographed under a high-power objective lens. However, if nucleated red blood cells appear in the sample or the cell proportion of nucleated red blood cells is greater than the preset proportion, when the target number of white blood cells is identified and located under a low-power objective lens, the images of less than the target number of white blood cells may be photographed under a high-power objective lens. In response to this situation, the control device will increase the number of white blood cells identified and located under a low-power objective lens. That is, in this case, the control device controls the cell image analysis device to photograph under the first shooting condition, increasing the number of white blood cell images photographed under a low-power objective lens, so as to meet the requirements for the target number under a high-power objective lens.

[0224] Taking white blood cells (WBC) as an example, the cell image analysis device photographs the body part of the smear. If the count value of WBC is less than the first preset threshold, the control device also needs to increase the number of white blood cell images photographed. Usually, the cell image analysis device can photograph the body part of the smear to obtain WBC. If the count value of WBC is less than the first preset threshold, there may be a problem of insufficient cells. At this time, the control device 102 adjusts the shooting position, extending the shooting position from the body part to the edge to photograph the body part and the edge simultaneously. By extending, the shooting range is expanded, and the expansion of the shooting range may increase the shooting quantity. Therefore, in this embodiment, one way to increase the shooting quantity can be to increase the shooting range, and this embodiment will not elaborate on this one by one.

[0225] Through the above description of white blood cells, the control device can select a matching analysis mode and shooting condition for abnormal information related to white blood cells to adapt to the analysis of white blood cells.

[0226] Red blood cells

[0227] If the detection result of the sample to be analyzed includes abnormal information related to red blood cells, the control device 102 selects the red blood cell analysis mode or a combined mode including the red blood cell analysis mode. In the combined mode, the shooting conditions of the red blood cell analysis mode are related to the detection result of red blood cells, and the shooting conditions of other analysis modes are related to the detection results of other cells. If the detection results of other cells are normal, the shooting conditions of other cell analysis modes are different from those when the detection results of other cells are abnormal. In this embodiment, the abnormal information related to red blood cells is used to indicate that the red blood cells in the sample to be analyzed are abnormal. For example, the abnormal information related to red blood cells includes but is not limited to at least one of the red blood cell count value deviating from the normal range, red blood cell aggregation, red blood cell fragments, and the red blood cell volume being less than a preset volume. Among them, red blood cell aggregation means that some red blood cells in the sample to be analyzed are concentrated in one area, red blood cell fragments indicate that there are red blood cells with incomplete morphology in the sample to be analyzed, and the red blood cell volume being less than the preset volume indicates that there are microcytic red blood cells in the sample to be analyzed. For example, the preset volume can be but is not limited to 70 fL (femtoliters). If the red blood cell volume MCV < 70 fL, it indicates that there are microcytic red blood cells in the sample to be analyzed. For the detection results including such abnormal information, the control device will select the red blood cell analysis mode or a combined mode including the red blood cell analysis mode as the analysis mode of the cell image analysis device, and control the cell image analysis device to scan the smear in the selected mode to obtain cell images.

[0228] For the two abnormalities of red blood cell fragments and the red blood cell volume being less than the preset volume, the cell image analysis mode can also output at least one of the red blood cell fragment ratio and the microcytic red blood cell ratio, so as to judge whether there are red blood cell fragments in the sample to be analyzed through the red blood cell fragment ratio, and similarly judge whether there are microcytic red blood cells in the sample to be analyzed through the microcytic red blood cell ratio.

[0229] One way to judge whether there are red blood cell fragments in the sample to be analyzed is as follows: a judgment criterion for the existence of red blood cell fragments is set in the cell image analysis device, and it is judged whether there are red blood cell fragments according to the red blood cell fragment ratio of the current sample to be analyzed and the judgment criterion. For example, the judgment criterion is a preset ratio for the non-existence of red blood cell fragments. If the red blood cell fragment ratio of the current sample to be analyzed is greater than this preset ratio, it indicates that there are red blood cell fragments. If the red blood cell fragment ratio of the current sample to be analyzed is not greater than this preset ratio, it indicates that there are no red blood cell fragments. The method for judging whether there are microcytic red blood cells in the sample to be analyzed is similar to the method for judging whether there are red blood cell fragments in the sample to be analyzed, and will not be described in this embodiment.

[0230] For the above abnormal information related to red blood cells, the control device can also select different shooting conditions: If the abnormal information related to red blood cells includes red blood cell aggregation, the control device controls the cell image analysis device to shoot the tail of the smear to obtain the cell image of the tail of the smear, and recognizes the cell distribution of the tail through the cell image of the tail to analyze whether red blood cell aggregation appears in the sample to be analyzed.

[0231] If the volume of red blood cells is less than the preset volume, the control device controls the cell image analysis device to perform a small-area red blood cell scan on the smear, that is, for red blood cells with a volume less than the preset volume, the control device needs to control the shooting range of the cell image analysis device to control the cell image analysis device to perform a red blood cell scan within a small shooting range. The smaller the shooting range, the shorter the shooting duration of the cell image analysis device. Therefore, this kind of control can save the working time of the cell image analysis device.

[0232] Through the above description of red blood cells, the control device can select a matching analysis mode and shooting conditions for the abnormal information related to red blood cells, and the cell image analysis device analyzes the red blood cells in the sample to be analyzed by using the matching analysis mode and shooting conditions.

[0233] Platelet

[0234] If the test result of the sample to be analyzed includes abnormal information related to platelets, the control device selects a platelet analysis mode or a combined mode including a platelet analysis mode, so as to use one of the platelet analysis mode, the platelet analysis mode and other analysis modes as the analysis mode of the cell image analysis device. In the combined mode, the shooting conditions of the platelet analysis mode are related to the test result of platelet cells, and the shooting conditions of other analysis modes are related to the test results of other cells. If the test results of other cells are normal, the shooting conditions of the other cell analysis mode are different from those when the test results of other cells are abnormal.

[0235] Among them, the abnormal information related to platelets is used to indicate that the platelets in the sample to be analyzed are abnormal. The abnormal information related to platelets includes but is not limited to at least one of platelet aggregation and the platelet count value being lower (less than) the second preset threshold. In these abnormal information, the cell image analysis device at least uses the platelet analysis mode for shooting and analysis.

[0236] For the above abnormal information related to platelets, the shooting conditions that the control device can adopt can be the following conditions:

[0237] If the count value of platelets is lower than the second preset threshold, the control device selects the first shooting condition; if the count value of platelets is not lower than (i.e., not less than) the second preset threshold, the control device selects the second shooting condition, where the shooting positions or shooting ranges corresponding to the first shooting condition and the second shooting condition are different. That is, the control device controls one of the shooting position and shooting range of the smear according to the relationship between the count value of platelets and the second preset threshold.

[0238] If the shooting range is controlled, the shooting range under the first shooting condition is larger than that under the second shooting condition. This is because if the count value of platelets is less than the second preset threshold, it indicates that the count value of platelets in the sample to be analyzed may decrease, and the platelets in the sample to be analyzed may decrease. At this time, a larger area needs to be shot to increase the probability of shooting platelets. If the count value of platelets is not less than the second preset threshold, it indicates that the count value of platelets in the sample to be analyzed may increase, and the platelets in the sample to be analyzed may increase. At this time, shooting a smaller area may be able to shoot platelets. Therefore, the shooting range under the first shooting condition is larger than that under the second shooting condition.

[0239] If the shooting position is controlled, the shooting position corresponding to the first shooting condition includes the tail and / or edge of the smear to obtain cell images of the tail and / or edge, and determine whether platelet aggregation occurs in the sample to be analyzed and whether the decrease in the count value of platelets is caused by platelet aggregation according to the obtained cell images. The shooting position corresponding to the second shooting condition includes the body part of the smear because the count value of platelets does not decrease under the second shooting condition, and at this time, the body part of the smear can be normally shot.

[0240] The above explains the analysis mode of the control device and the selection of shooting conditions respectively starting from the abnormal information related to white blood cells, the abnormal information related to red blood cells, and the abnormal information related to platelets. In addition to the above selection methods, the control device can also refer to other aspects to select the analysis mode or shooting conditions.

[0241] A method of selecting an analysis mode: The control device selects an analysis mode according to the combination of the results corresponding to white blood cells, red blood cells, and platelets in the detection results. For example, if the count values of white blood cells, red blood cells, and platelets in the detection results of the sample to be analyzed are all lower than the corresponding preset thresholds, the control device selects the white blood cell analysis mode, the red blood cell analysis mode, and the platelet analysis mode, so that the cell image analysis device can sequentially call the white blood cell analysis mode, the red blood cell analysis mode, and the platelet analysis mode. The calling order of these three cell analysis modes is not limited in this embodiment.

[0242] One point that needs to be explained here is that when the control device selects an analysis mode based on the count values of white blood cells, red blood cells, and platelets, the preset thresholds it refers to are corresponding to each type of cell. For example, the respective relevant test values of white blood cells, red blood cells, and platelets in the sample to be analyzed are: WBC = 3.0*10 9 / L, HGB = 80*10 9 / L, PLT = 95*10 9 / L. The control device determines that the count values of these three types of cells are all less than the corresponding preset thresholds: WBC < 4*10 9 / L and HGB < 100 g / L and PLT < 100*10 9 / L. Then the control device selects the simple mode that combines the white blood cell analysis mode, red blood cell analysis mode, and platelet analysis mode, so that the cell image analysis device can comprehensively analyze the sample to be analyzed at the minimum time cost. The white blood cell analysis mode, red blood cell analysis mode, and platelet analysis mode in the simple mode can have different shooting conditions from the analysis modes when the cells are abnormal.

[0243] Another way to select the analysis mode is: the control device is used to select the analysis mode according to the sample information. One way to select the analysis mode according to the sample information is: if the sample information includes that the sample to be analyzed comes from pediatrics and there is no information on historical medical records, then select the simple mode that combines the white blood cell analysis mode, red blood cell analysis mode, and platelet analysis mode. Thus, for the samples of first-time pediatric patients, the cell image analysis device can analyze the samples under these three analysis modes: the cell analysis mode, red blood cell analysis mode, and platelet analysis mode, enabling the cell image analysis device to comprehensively analyze the sample to be analyzed at the minimum time cost. If the samples of first-time patients in other departments also need to be comprehensively analyzed, the control device in this embodiment can also select the white blood cell analysis mode, red blood cell analysis mode, and platelet analysis mode for the samples of first-time patients in other departments.

[0244] A method for selecting shooting conditions: The control device presets at least two types of abnormal information and the shooting conditions corresponding to each type of abnormal information according to the detection results of historical samples. After obtaining the detection results of any sample to be analyzed, the control device determines whether the preset abnormal information appears based on the detection results of the sample to be analyzed. If the first type of abnormal information appears, the first shooting condition is selected; if the second type of abnormal information appears, the second shooting condition different from the first shooting condition is selected. Thus, the selection of the shooting conditions of the control device is controlled according to the abnormal information and shooting conditions set for the sample to be analyzed. When the control device presets the abnormal information and shooting conditions, it can be set through a man-machine interaction method. For example, the user sets the abnormal information and shooting conditions on the display interface corresponding to the control device to allow user intervention and improve flexibility and convenience.

[0245] Among them, the degrees of abnormality of the first type of abnormal information and the second type of abnormal information are different. The higher the degree of abnormality, the higher the requirements for the cell image analysis device and the earlier the processing order. The lower the degree of abnormality, the lower the requirements for the cell image analysis device and the processing order can be postponed. The following takes several types of abnormal information as examples for illustration:

[0246] An example: The first type of abnormal information includes abnormal cell prompts or alarm information, and the abnormal cell prompts or alarms include but are not limited to blast cell alarms, nucleated red blood cell alarms, etc. In the case of the first type of abnormal information, the first shooting condition includes selecting the first objective lens to shoot the smear of the sample to be analyzed; the second type of abnormal information includes information on abnormal cell classification ratios, such as abnormal white blood cell classification. At this time, the second shooting condition includes selecting the second objective lens to shoot the smear of the sample to be analyzed. The magnification of the first objective lens is higher than that of the second objective lens. Thus, for the first type of abnormal information, the cell image analysis device is controlled to use an objective lens with a higher magnification to magnify the cells corresponding to the first type of abnormal information by a larger magnification for easy cell observation. For the second type of abnormal information, an objective lens with a lower magnification can be used because the degree of abnormality of the second type of abnormal information is lower than that of the first type of abnormal information. At this time, it is not necessary to magnify by a larger magnification to recheck the second type of abnormal information.

[0247] In this embodiment, the magnification of the first objective lens can be, but is not limited to, 100 times, and the magnification of the second objective lens can be, but is not limited to, 40 times. In the actual analysis process, the magnifications of the first objective lens and the second objective lens can be determined according to the analysis requirements, but the magnification relationship between the first objective lens and the second objective lens satisfies that the magnification of the first objective lens is higher (i.e., greater) than that of the second objective lens.

[0248] Another example: The first type of abnormal information includes that the proportion of abnormal cells related to white blood cells is less than a preset proportion, the second type of abnormal information includes that the proportion of abnormal cells related to white blood cells is not less than the preset proportion, and the number of white blood cell images captured under the first shooting condition is less than the number of white blood cell images captured under the second shooting condition.

[0249] Among them, abnormal cells related to white blood cells will affect the number of white blood cells obtained during the analysis process. For example, in a normal sample, the proportion of nucleated red blood cells related to white blood cells is 0. At this time, the cell image analysis device captures the number of white blood cell images (pre-set target number) during the analysis process. However, if the proportion of nucleated red blood cells is greater than 0, when taking pictures, the nucleated red blood cell images may be regarded as white blood cell images. Therefore, if the target number of white blood cell images is still captured, the actual number of white blood cell images in these images will not reach the target number. In view of this situation, it is necessary to capture a number of white blood cell images greater than the target number. Therefore, in this embodiment, when the proportion of abnormal cells related to white blood cells is less than the preset proportion, the corresponding number of white blood cell images captured is less than the corresponding number of white blood cell images captured when the proportion of abnormal cells related to white blood cells is not less than the preset proportion, so as to meet the requirements of the cell image analysis device for white blood cell images during analysis.

[0250] Another example: If the proportion of abnormal cells is high, then choose to reduce the number of cell captures to save the capture time.

[0251] For example, when the proportion of neutrophils is 95%, the cell image analysis device captures fewer cell images. For example, by capturing 50 cell images, most neutrophils can be captured, thus saving the capture duration of the cell image analysis device while capturing neutrophils.

[0252] Another method for selecting shooting conditions: If the analysis mode selected by the control device is the white blood cell analysis mode or a combined mode including the white blood cell analysis mode, then judge whether the number of red blood cells is less than a preset threshold according to the detection result; if the number of red blood cells is less than the preset threshold, select the first shooting condition to capture white blood cell images; if the number of red blood cells is not less than the preset threshold, select the second shooting condition to capture white blood cell images; where the shooting position of the first shooting condition is different from the shooting position of the second shooting condition, so as to realize the determination of the capture of white blood cell images by judging the number of red blood cells.

[0253] For example, when the number of red blood cells is less than the preset threshold, the shooting position corresponding to the first shooting condition includes the junction of the body and the tail of the smear (referred to as the body-tail junction), and when the number of red blood cells is not less than the preset threshold, the shooting position corresponding to the second shooting condition includes the body of the smear.

[0254] The above describes how the control device selects an analysis mode based on at least one of the detection results and sample information, and selects shooting conditions based on the detection results. For better understanding, the selection of the above analysis mode and shooting conditions is listed in tabular form in the attached table. In some examples, if the shooting conditions or analysis mode are not described, it is considered that there is no change to the cell image analysis device for this example. However, the attached table is only a list of some examples and cannot be regarded as limiting the protection scope of this embodiment.

[0255] Table 2 Selection Table of Analysis Mode and Shooting Conditions

[0256]

[0257]

[0258] In another embodiment, as Figure 1 shown in the sample analysis system, which includes:

[0259] A blood cell analyzer 101 for detecting at least one sample to obtain the detection result of at least one sample.

[0260] A control device 102 for obtaining the detection result of at least one sample.

[0261] A smear preparation device 103 for preparing smears of samples to be analyzed by the cell image analysis device to obtain smears of each sample to be analyzed.

[0262] A cell image analysis device 104 for photographing and analyzing the smears of samples to be analyzed to obtain cell images and cell image analysis results of the samples to be analyzed.

[0263] The control device 102 is further configured to: if the value of at least one type of cell in the detection result of the sample to be analyzed is less than a preset threshold, control the cell image analysis device to photograph the smear using a first shooting condition to obtain images of at least one type of cell; if the value of at least one type of cell in the detection result of the sample to be analyzed is not less than the preset threshold, control the cell image analysis device to photograph the smear of the sample using a second shooting condition different from the first shooting condition to obtain images of at least one type of cell.

[0264] The shooting ranges corresponding to the first shooting condition and the second shooting condition are different.

[0265] The sample analysis system is different from the above sample analysis system in that: in this embodiment, the control device of the sample analysis system controls the shooting range of the cell image analysis device according to the relationship between at least one cell value in the detection result and a preset threshold, so that the shooting range is different in different situations. For example, the shooting range corresponding to the first shooting condition is larger than the shooting range corresponding to the second shooting condition. The at least one cell value includes but is not limited to the number of white blood cells, the number of red blood cells, or the number of platelets. For example, if the white blood cell count of the sample to be analyzed is low, that is, the count value of white blood cells is lower than the preset threshold, the shooting range of the smear of this sample is enlarged to obtain the target number (such as 100) of white blood cells within a larger shooting range.

[0266] In the above Figure 1 sample analysis system, it is introduced that the shooting ranges corresponding to the first shooting condition and the second shooting condition are different. This embodiment can refer to the above description and will not be elaborated herein.

[0267] Regarding the above Figure 1 sample analysis system, another implementation manner thereof is as follows:

[0268] A blood cell analyzer 101 is used to detect at least one sample to obtain the detection result of the at least one sample.

[0269] A control device 102 is used to obtain the detection result of the at least one sample.

[0270] A smear preparation device 103 is used to prepare a smear of the sample to be analyzed by the cell image analysis device to obtain the smear of the sample to be analyzed.

[0271] A cell image analysis device 104 is used to shoot and analyze the smear of the sample to be analyzed to obtain the cell image and the cell image analysis result of the sample to be analyzed.

[0272] The control device 102 is further used for:

[0273] If the test result of the sample to be analyzed includes abnormal cells, the number of cell image captures is adjusted according to the proportion of abnormal cells or the abnormal alarm information. The abnormal alarm information includes information representing the proportion of abnormal cells. The abnormal cells include NRBC or blast cells, etc. Among them, the proportion of abnormal cells is positively or negatively correlated with the number of cell image captures. For example, if the test result of the sample to be analyzed includes NRBC, the higher the proportion of NRBC, the more cells (such as white blood cells) the cell image analysis device 104 locates and captures. For example, if the proportion of NRBC is 1%, the cell image analysis device 104 locates 150 white blood cells (including suspected white blood cells) and captures the located cells; if the proportion of NRBC is 2%, the cell image analysis device 104 locates 200 white blood cells (including suspected white blood cells) and captures the located cells. If the abnormal cell is a blast cell and the proportion of blast cells is very high, it may not be necessary to capture many cells to identify the blast cell; if the proportion of blast cells is very low, more cells may need to be captured to avoid being missed due to the low proportion of cells.

[0274] For specific descriptions, please refer to the relevant descriptions in the above embodiments, and they will not be elaborated in this embodiment.

[0275] For the above Figure 1 shown sample analysis system, an optional structure of the control device in each sample analysis system is as Figure 3 shown, and at least includes: a processing component 111, a RAM 112, a ROM 113, a communication interface 114, a memory 116, and an I / O interface 115. Among them, the processing component 111, the RAM 112, the ROM 113, the communication interface 114, the memory 116, and the I / O interface 115 communicate through a bus 117.

[0276] The processing component can be a CPU, a GPU, or other chips with computing capabilities.

[0277] The memory 116 stores various computer programs for the processor component 111 to execute, such as an operating system and application programs, and the data required to execute the computer programs. In addition, during the sample analysis process, any information that needs to be locally stored can be stored in the memory 116.

[0278] The I / O interface 115 is composed of a serial interface such as USB, IEEE1394 or RS-232C, a parallel interface such as SCSI, IDE or IEEE1284, and an analog signal interface composed of a D / A converter and an A / D converter, etc. An input device composed of a keyboard, a mouse, a touch screen or other control buttons is connected to the I / O interface 115, and the user can directly input data to the control device 110 with the input device. In addition, a display device with a display function, such as a liquid crystal screen, a touch screen, an LED display screen, etc., can also be connected to the I / O interface 115. The control device can output information to the display device for display in an image display manner, such as an analysis mode, a detection result, etc.

[0279] The communication interface 114 can be an interface of any currently known communication protocol. The communication interface 114 communicates with the outside world through a network. The control device can transmit data with any device connected through the network through the communication interface 114 according to a certain communication protocol.

[0280] For the above Figure 1 shown sample analysis system, an optional structure of the cell image analysis device in each sample analysis system is as Figure 4 and Figure 5 shown. The cell image analysis device at least includes an imaging device 1041, a smear moving device 1042 and an image analysis device 1043.

[0281] The imaging device 1041 includes a camera 10412 and a lens group 10411 and is used for photographing cells in the sample to be analyzed smeared on the smear. The smear moving device 1042 is used to move the smear relative to the imaging device 1041 so that the imaging device 1041 can photograph the cell images in a specific area of the smear. The image analysis device 1043 is used to analyze the cell images of the smear.

[0282] As Figure 5 shown, the lens group 10411 may include a first objective lens 3111, a second objective lens 3112 and an eyepiece 3114. One of the first objective lens 3111 and the second objective lens 3112 is a low-power objective lens, and the other is a high-power objective lens. For example, the first objective lens 3111 is a high-power objective lens and the second objective lens 3112 is a low-power objective lens. The first objective lens can be a 100-fold objective lens, and the second objective lens 3112 can be a 10-fold objective lens. The lens group 10411 may further include a third objective lens 3113, and the magnification of the third objective lens 3113 is between the magnifications of the first objective lens and the second objective lens. For example, the third objective lens 3113 can be a 40-fold objective lens.

[0283] The cell image analysis device 104 further includes an identification device 1044, a smear clamping device 1045, and a smear recycling device 1046. The identification device 1044 is used to identify the sample information of the smear. The smear clamping device 1045 is used to clamp the smear from the identification device 1044 onto the smear moving device 1042, so that the smear moving device 1042 drives the smear to move relative to the imaging device 1041. Further, after the imaging device 1041 captures the cell image of the smear, the image analysis device 1043 analyzes the cell image of the smear. The smear recycling device 1046 is used to place the smear that has been analyzed by the image analysis device 1043.

[0284] The cell image analysis device 104 further includes a smear basket loading device 1047 for loading a smear basket containing the smear to be tested. The smear clamping device 1045 is also used to clamp the smear in the smear basket loaded on the smear basket loading device 1047 to the identification device 1044 for sample information identification.

[0285] In this embodiment, the smear in the smear basket loaded on the smear basket loading device 1047 can be placed in the smear basket by the user or transported by other transport devices, so as to be transported to the cell image analysis device by the transport device after the smear preparation device prepares the smear.

[0286] Based on this, this embodiment provides an alternative structure of another sample analysis system, as Figure 6 shown, Figure 6 The sample analysis system 600 shown can include: a blood cell analyzer 601, a control device 602, a smear preparation device 603, a cell image analysis device 604, and a transport device 605.

[0287] The transport device 605 is used to transport the sample to be analyzed from the blood cell analyzer 601 to the smear preparation device 603, and transport the smear from the smear preparation device 603 to the cell image analysis device 604, so as to complete the transfer of the sample to be analyzed between the blood cell analyzer 601, the smear preparation device 603, and the cell image analysis device 604 through the transport device 605. In this way, any sample to be analyzed can complete automatic detection, smear preparation, image capture, and analysis through the blood cell analyzer 601, the smear preparation device 603, and the cell image analysis device 604.

[0288] For Figure 6 the sample analysis system 600 shown, the blood cell analyzer 601, the control device 602, the smear preparation device 603, and the cell image analysis device 604 can refer to the description of the above sample analysis system, and this embodiment will not be described in detail herein.

[0289] As described above from the perspective of the sample analysis system, the control device in the sample analysis system selects the shooting conditions. For the cell image analysis device, it can also select the shooting conditions. For example, Figure 7 As shown, it shows an optional structure of a cell image analysis device. Figure 7 The cell image analysis device 700 shown in the figure may include: a shooting device 701 and a control device 702.

[0290] The shooting device 701 is used to shoot the smear of the sample to be analyzed. In this embodiment, for the structure of the shooting device 701, please refer to the imaging device in the cell image analysis device shown in the above Figure 4 and Figure 5 figure.

[0291] The control device 702 is used to obtain the test results obtained by detecting the sample to be analyzed through a blood cell analyzer and control the shooting device 701 to select the corresponding analysis mode and / or shooting conditions to perform cell image shooting and analysis on the smear of the sample to be analyzed according to the test results.

[0292] The control device 702 is further used to: if the value of at least one type of cell in the test results of the sample to be analyzed is less than the preset threshold, control the shooting device to shoot the smear of the sample to be analyzed using the first shooting conditions to obtain images of at least one type of cell; if the value of at least one type of cell in the test results of the sample to be analyzed is not less than the preset threshold, control the shooting device to shoot the smear of the sample to be analyzed using the second shooting conditions different from the first shooting conditions to obtain images of at least one type of cell. At least one of the number of cell image shootings, shooting ranges, shooting positions, shooting objective lens magnifications, and focusing ranges corresponding to the first shooting conditions and the second shooting conditions is different. In this embodiment, for the structure of the control device 702, please refer to the structure of the control device in the sample analysis system shown in the above Figure 3 figure. The manner in which the control device 702 selects the corresponding analysis mode and / or shooting conditions according to the test results is similar to that in the foregoing embodiments and will not be elaborated herein.

[0293] The difference from the above sample analysis system is that in this embodiment, the control device in the cell image analysis device selects the shooting conditions, and the control device in the cell image analysis device selects the shooting conditions according to the relationship between the value of at least one type of cell in the test results of the sample to be analyzed and the preset threshold.

[0294] For example, if the value of at least one type of cell in the test result of the sample to be analyzed is less than the preset threshold, the first shooting condition is adopted; if the value of at least one type of cell in the test result of the sample to be analyzed is not less than the preset threshold, the second shooting condition is adopted; at least one of the number of cell images, shooting range, shooting position, shooting objective lens magnification, and focusing range corresponding to the first shooting condition and the second shooting condition adopted is different. For specific descriptions, please refer to the description of the control device in the above sample analysis system.

[0295] In this embodiment, the value of at least one type of cell includes at least one of the number, proportion, and volume of at least one type of cell. For the description of the value of at least one type of cell, please refer to the above Figure 1 description in the sample analysis system shown.

[0296] Through Figure 7 the cell image analysis device shown, the control device in the cell image analysis device selects the shooting condition according to the relationship between the value of at least one type of cell in the test result of the sample to be analyzed and the preset threshold. In this way, when the cell image analysis device analyzes any sample to be analyzed, it can select a matching shooting condition according to the test result of the sample to be analyzed, which is convenient for selecting the shooting condition and improves the processing efficiency and accuracy.

[0297] Please refer to Figure 8 , which shows an optional flowchart of a blood cell analysis method provided by an embodiment of the present invention. Figure 8 The blood cell analysis method shown corresponds to the above Figure 1 sample analysis system shown. For the description of the Figure 8 blood cell analysis method shown, please refer to the Figure 1 sample analysis system shown. It will not be elaborated in this embodiment. Among them, Figure 8 the blood cell analysis method shown may include the following steps:

[0298] 801: Obtain the test result of the sample to be analyzed.

[0299] 802: If the value of at least one type of cell in the test result of the sample to be analyzed is less than the preset threshold, control the cell image analysis device to shoot the smear of the sample to be analyzed under the first shooting condition to obtain the images of at least one type of cell;

[0300] 803: If the value of at least one type of cell in the test result of the sample to be analyzed is not less than the preset threshold, control the cell image analysis device to shoot the smear of the sample to be analyzed under the second shooting condition different from the first shooting condition to obtain the images of at least one type of cell.

[0301] The number of cell images captured by the cell image analysis device under the first shooting condition is greater than the number of cell images captured under the second shooting condition.

[0302] Through the above Figure 8 The blood cell analysis method shown can select a matching shooting condition according to the relationship between the value of at least one type of cell in the test result of the sample to be analyzed and a preset threshold, so as to shoot the cell image of the sample to be analyzed with the matching shooting condition (such as shooting the abnormal part indicated by the test result of the sample to be analyzed specifically), enabling the cell image analysis device to obtain a cell image matching the test result for analysis, and improving the processing efficiency and accuracy of the cell image analysis device.

[0303] In this embodiment, the value of at least one type of cell includes at least one of the number, proportion, and volume of at least one type of cell, or the value of at least one type of cell includes at least one of the count value of white blood cells, the count value of red blood cells, and the count value of platelets.

[0304] When selecting a matching shooting condition according to the relationship between the value of at least one type of cell in the test result of the sample to be analyzed and a preset threshold, the selected shooting condition can be: at least one of the shooting range and shooting position corresponding to the first shooting condition is different from that of the second shooting condition, that is, at least one of the number of cell images, shooting range, and shooting position corresponding to the first shooting condition and the second shooting condition is different.

[0305] For example, the shooting range of the smear by the cell image analysis device under the first shooting condition is greater than the shooting range of the smear under the second shooting condition; the shooting position of the smear by the cell image analysis device under the first shooting condition is different from the shooting position of the smear under the second shooting condition.

[0306] In this embodiment, at least one type of cell may include platelets; for platelets, the shooting positions are different when the relationship between the count value of platelets and the corresponding preset threshold is different. For example, if the count value of platelets in the test result of the sample to be analyzed is less than the corresponding preset threshold, the cell image analysis device is controlled to adopt the first shooting condition; or, if the count value of platelets in the test result of the sample to be analyzed is not less than the corresponding preset threshold, the cell image analysis device is controlled to adopt the second shooting condition.

[0307] Among them, the shooting positions of the smear by the cell image analysis device under the first shooting condition include the tail and / or the edge of the smear, and the shooting positions of the smear under the second shooting condition include the body of the smear. The reason for shooting in this way is that: if the counted value of platelets is less than the preset threshold, it may be that platelet aggregation occurs in the sample to be analyzed. By shooting the tail and / or the edge to obtain the cell images of the corresponding area, and then analyzing the cell images of the tail and / or the edge to analyze whether the decrease in the counted value of platelets (i.e., less than the preset threshold) is caused by platelet aggregation.

[0308] Figure 9 The following shows an optional process of another blood cell analysis method provided by an embodiment of the present invention, which may include the following steps:

[0309] 901: Obtain the test result of the sample to be analyzed.

[0310] 902: If the value related to the cell volume in the values of at least one type of cell in the test result is less than the preset threshold, control the cell image analysis device to shoot the smear of the sample to be analyzed under the first shooting condition to obtain the images of at least one type of cell.

[0311] 903: If the value related to the cell volume in the values of at least one type of cell in the test result is not less than the preset threshold, control the cell image analysis device to shoot the smear of the sample to be analyzed under the second shooting condition different from the first shooting condition to obtain the images of at least one type of cell.

[0312] Figure 9 For the description of the sample analysis system 9 of the blood cell analysis method shown above, reference may be made to the above sample analysis system, which will not be elaborated in this embodiment.

[0313] Among them, the focusing ranges corresponding to the first shooting condition and the second shooting condition are different. The difference in the focusing range can be that: the focusing range corresponding to the second shooting condition is greater than the focusing range corresponding to the first shooting condition. For example, when shooting small cells (the value related to the cell volume is less than the preset threshold), a smaller focusing range is used, and when shooting large cells (the value related to the cell volume is greater than the preset threshold), a larger focusing range is used. Shooting with a larger focusing range can ensure the shooting clarity of large cells, and shooting small cells with a smaller focusing range can not only ensure clarity but also save shooting time.

[0314] Through the above Figure 9 The shown sample analysis system can select the shooting condition of the cell image analysis device according to the relationship between the value related to the cell volume and the preset threshold, thereby selecting a matching shooting condition according to the value related to the cell volume in the test result, enabling the cell image analysis device to obtain cell images matching the test result for analysis, and improving the processing efficiency and processing accuracy of the cell image analysis device.

[0315] Figure 10 shows an alternative process of another blood cell analysis method provided by an embodiment of the present invention. The Figure 10 shown blood cell analysis method is directed to platelets. According to the relationship between the platelet count value and a preset threshold, shooting conditions are selected, and may include the following steps:

[0316] 1001: Obtain the test result of the sample to be analyzed.

[0317] 1002: If the platelet count value in the test result is less than the preset threshold, control the cell image analysis device to shoot the smear of the sample to be analyzed under the first shooting condition to obtain images of at least one type of cell.

[0318] 1003: If the platelet count value in the test result is not less than the preset threshold, control the cell image analysis device to shoot the smear of the sample to be analyzed under the second shooting condition different from the first shooting condition to obtain images of at least one type of cell.

[0319] The shooting positions corresponding to the first shooting condition include the tail and / or edge of the smear, and the shooting positions corresponding to the second shooting condition include the body part of the smear.

[0320] For Figure 10 the description of the shown blood cell analysis method, reference may be made to the above sample analysis system. By Figure 10 the shown blood cell analysis method can select shooting conditions according to the relationship between the platelet count value and the preset threshold. Especially when the platelet count value decreases (the platelet count value is less than the preset threshold), control the shooting of the tail and / or edge of the smear to determine whether the decrease in the platelet count value is caused by platelet aggregation, and shoot the reason for the decrease in the platelet count value in a targeted manner.

[0321] Please refer to Figure 11 , which shows an alternative process of another blood cell analysis method provided by an embodiment of the present invention. Figure 11 For the description of the shown blood cell analysis method and the sample analysis system, reference may be made to the above sample analysis system, which will not be elaborated in this embodiment. Among them Figure 11 the shown blood cell analysis method may include the following steps:

[0322] 1101: Obtain the test result of the sample to be analyzed and the sample information of the sample to be analyzed.

[0323] 1102: Select an analysis mode of the cell image analysis device based on at least one of the detection results of the sample to be analyzed and the sample information of the sample to be analyzed. The analysis mode includes at least one mode or a combination of at least two modes among the white blood cell analysis mode, red blood cell analysis mode, and platelet analysis mode.

[0324] 1103: Select shooting conditions according to the detection results of the sample to be analyzed.

[0325] 1104: Control the cell image analysis device to take pictures of the smear of the sample to be analyzed under the selected analysis mode according to the selected shooting conditions.

[0326] Among them, the shooting conditions are related to at least one of the number of cell images taken, shooting range, shooting position, shooting objective lens magnification, and focusing range.

[0327] The analysis modes and shooting conditions matching the three types of cells, namely white blood cells, red blood cells, and platelets, are described below:

[0328] White blood cells

[0329] The method of selecting the analysis mode according to the white blood cells in the detection results can be: Selecting the analysis mode of the cell image analysis device based on at least one of the detection results of the sample to be analyzed and the sample information of the sample to be analyzed includes: If the detection results of the sample to be analyzed include abnormal information related to white blood cells, then select the white blood cell analysis mode or a combined mode including the white blood cell analysis mode;

[0330] The corresponding method of selecting the shooting conditions according to the white blood cells in the detection results can be: Selecting the shooting conditions according to the detection results of the sample to be analyzed includes: If the abnormal information related to white blood cells is that the count value of white blood cells is lower than the first preset threshold or abnormal cells related to white blood cells, then select the first shooting condition; If the abnormal information related to white blood cells is that the count value of white blood cells is not lower than the first preset threshold or there are no abnormal cells related to white blood cells, then select the second shooting condition;

[0331] Among them, the number of white blood cell images taken corresponding to the first shooting condition is greater than the number of white blood cell images taken corresponding to the second shooting condition.

[0332] Red blood cells

[0333] The method of selecting an analysis mode based on red blood cells in the test results can be: Selecting the analysis mode of the cell image analysis device based on at least one of the test results of the sample to be analyzed and the sample information of the sample to be analyzed includes: If the test results of the sample to be analyzed include abnormal information related to red blood cells, then select the red blood cell analysis mode or a combined mode including the red blood cell analysis mode; The abnormal information related to red blood cells includes, but is not limited to, at least one of the count value of red blood cells deviating from the normal range, red blood cell aggregation, red blood cell fragments, and the volume of red blood cells being less than a preset volume.

[0334] The corresponding method of selecting shooting conditions based on red blood cells in the test results can be: Selecting shooting conditions based on the test results of the sample to be analyzed includes: If the abnormal information related to red blood cells includes red blood cell aggregation, the selected shooting conditions indicate shooting the tail of the smear;

[0335] Or,

[0336] If the volume of red blood cells (MCV) is less than the preset volume, the selected shooting conditions indicate scanning red blood cells in a small area of the smear.

[0337] Platelet

[0338] The method of selecting an analysis mode based on platelets in the test results can be: Selecting the analysis mode of the cell image analysis device based on at least one of the test results of the sample to be analyzed and the sample information of the sample to be analyzed includes: If the test results of the sample to be analyzed include abnormal information related to platelets, then select the platelet analysis mode or a combined mode including the platelet analysis mode; The abnormal information related to platelets includes at least one of platelet aggregation and the platelet count value being lower than a second preset threshold;

[0339] The corresponding method of selecting shooting conditions based on platelets in the test results can be: Selecting shooting conditions based on the test results of the sample to be analyzed includes: If the platelet count value is lower than the second preset threshold, then select the first shooting condition; If the platelet count value is not lower than the second preset threshold, then select the second shooting condition; Among them, the shooting positions or shooting ranges corresponding to the first shooting condition and the second shooting condition are different.

[0340] For example, the shooting range corresponding to the first shooting condition is larger than the shooting range corresponding to the second shooting condition; or, the shooting position corresponding to the first shooting condition includes the tail and / or edge of the smear; The shooting position corresponding to the second shooting condition includes the body of the smear.

[0341] Other methods of selecting analysis modes and shooting conditions are as follows:

[0342] One way to select an analysis mode is as follows: Select the analysis mode of the cell image analysis device based on at least one of the detection results of the sample to be analyzed and the sample information of the sample to be analyzed, including: If the white blood cells, red blood cells, and platelets in the detection results of the sample to be analyzed are all lower than the corresponding preset thresholds, then select the simple mode that combines the white blood cell analysis mode, the red blood cell analysis mode, and the platelet analysis mode;

[0343] Another way to select an analysis mode is: If the sample information includes that the sample to be analyzed comes from pediatrics and there is no information on historical medical records, then select the simple mode that combines the white blood cell analysis mode, the red blood cell analysis mode, and the platelet analysis mode.

[0344] One way to select shooting conditions according to the detection results can be: Judge whether preset abnormal information appears according to the detection results of the sample to be analyzed; If the first abnormal information appears, then select the first shooting condition; If the second abnormal information appears, then select the second shooting condition different from the first shooting condition.

[0345] The first abnormal information includes abnormal cell prompts or alarm information, and the first shooting condition includes selecting the first objective lens to shoot the smear of the sample to be analyzed; The second abnormal information includes information on abnormal cell classification ratios, and the second shooting condition includes selecting the second objective lens to shoot the smear of the sample to be analyzed; Among them, the magnification of the first objective lens is higher than that of the second objective lens;

[0346] Or,

[0347] The first abnormal information includes that the proportion of abnormal cells related to white blood cells is less than the preset proportion, the second abnormal information includes that the proportion of abnormal cells related to white blood cells is not less than the preset proportion, and the number of white blood cell images taken under the first shooting condition is less than the number of white blood cell images taken under the second shooting condition.

[0348] Another way to select shooting conditions according to the detection results of the sample to be analyzed is: If the selected analysis mode is the white blood cell analysis mode or a combined mode including the white blood cell analysis mode, then judge whether the red blood cell count is less than the preset threshold according to the detection results;

[0349] If the red blood cell count is less than the preset threshold, then select the first shooting condition to shoot white blood cell images;

[0350] If the red blood cell count is not less than the preset threshold, then select the second shooting condition different from the first shooting condition to shoot white blood cell images;

[0351] Among them, the shooting position of the first shooting condition is different from that of the second shooting condition.

[0352] Through the above Figure 11The blood cell analysis method shown selects a matching analysis mode based on at least one of the test results and sample information, and selects a matching shooting condition based on the test results, realizing the automatic selection of the analysis mode and shooting condition, and improving the processing efficiency of the cell image analysis device. Moreover, the cell image analysis device can work under the analysis mode and shooting condition that match the sample to be analyzed, improving the processing efficiency and accuracy of the cell image analysis device.

[0353] Figure 12 Fig. shows an alternative process of another blood cell analysis method provided by an embodiment of the present invention. Figure 12 For the description of the sample analysis system of the blood cell analysis method shown, reference may be made to the above sample analysis system, which will not be elaborated in this embodiment. Among them Figure 12 The blood cell analysis method shown may include the following steps:

[0354] 1201: Obtain the test results of the sample to be analyzed.

[0355] 1202: If the value of at least one type of cell in the test results of the sample to be analyzed is less than a preset threshold, control the cell image analysis device to take a picture of the smear using the first shooting condition to obtain images of at least one type of cell.

[0356] 1203: If the value of at least one type of cell in the test results of the sample to be analyzed is not less than the preset threshold, control the cell image analysis device to take a picture of the smear of the sample using a second shooting condition different from the first shooting condition to obtain images of at least one type of cell.

[0357] The shooting ranges corresponding to the first shooting condition and the second shooting condition are different. For example, the shooting range corresponding to the first shooting condition is larger than the shooting range corresponding to the second shooting condition. In this embodiment, the value of at least one type of cell includes but is not limited to the number of white blood cells, the number of red blood cells, or the number of platelets.

[0358] Through the above Figure 12 shown blood cell analysis method, according to the relationship between the value of at least one type of cell in the test results and the preset threshold, control the shooting range of the cell image analysis device so that the shooting range is different in different situations.

[0359] An embodiment of the present invention also provides another blood cell analysis method, including the following steps:

[0360] (1) Obtain the test results of the sample to be analyzed.

[0361] (2) If the test result of the sample to be analyzed includes abnormal cells, the number of cell images captured is adjusted according to the proportion of abnormal cells. The higher the proportion of abnormal cells, the more cell images are captured by the cell image analysis device. For example, if the test result of the sample to be analyzed includes NRBC, the higher the proportion of NRBC, the more cell images (such as white blood cell images) are captured by the cell image analysis device 104. For example, when the proportion of NRBC is 1%, the cell image analysis device 104 captures 150 white blood cell images; when the proportion of NRBC is 2%, the cell image analysis device 104 captures 200 white blood cell images. For specific descriptions, please refer to the above system embodiment, and this embodiment will not be elaborated here.

[0362] As Figure 13 shown, in another embodiment of the present invention, a blood cell analysis method includes the following steps.

[0363] 1301: Obtain the test result of the sample analyzed by a blood cell analyzer.

[0364] 1302: Prepare a blood smear of the sample. The process of preparing the blood smear includes sucking the sample to be analyzed, dropping the sample onto a glass slide, and pushing the sample on the glass slide into a blood film to prepare the blood smear, and then staining and drying the blood smear, thereby completing the preparation of the sample blood smear.

[0365] 1303: If the test result of the sample includes infected red blood cells, control the cell image analysis device to capture the area with a thicker blood film on the blood smear to detect whether there are malaria parasites; wherein, the area with a thicker blood film on the blood smear includes the body and the tail of the blood smear. Since the blood film thickness decreases from the head to the body and from the body to the tail of the blood smear, that is, the blood film thickness of the head and the body is relatively thicker than that of the tail. In the area with a thicker blood film, it is easier to find malaria parasites. Therefore, in the case of an alarm of infected red blood cells, selecting to capture the body or the head of the blood smear is more likely to observe malaria parasites, thereby improving the detection efficiency.

[0366] The embodiment of the present invention also provides a storage medium storing executable instructions, configured to cause a processor to execute the executable instructions to implement the above blood cell analysis method.

[0367] Those skilled in the art should understand that the embodiments of the present invention can be provided as a method, a system, or a computer program product. Therefore, the embodiments of the present invention can take the form of a hardware embodiment, a software embodiment, or an embodiment combining software and hardware aspects. Moreover, the embodiments of the present invention can take the form of a computer program product implemented on one or more computer-usable storage media (including disk memories and optical memories, etc.) containing computer-usable program codes.

[0368] Embodiments of the present invention are described with reference to the flowcharts and / or block diagrams of methods, apparatuses (systems), and computer program products according to embodiments of the present invention. It should be understood that each flow and / or block in the flowchart and / or block diagram, and the combination of flows and / or blocks in the flowchart and / or block diagram, can be implemented by computer program operations. These computer program operations can be provided to the processor of a general-purpose computer, a special-purpose computer, an embedded processor, or other programmable data processing device to generate a machine, such that the operations executed by the processor of the computer or other programmable data processing device generate a means for implementing the functions specified in one flow Figure 1 one flow or multiple flows and / or blocks Figure 1 or a means for implementing the functions specified in multiple blocks.

[0369] These computer program operations can also be stored in a computer-readable memory that can direct a computer or other programmable data processing device to work in a specific manner, such that the operations stored in the computer-readable memory generate a manufactured article including an operating means that implements the functions specified in one flow Figure 1 one flow or multiple flows and / or blocks Figure 1 or a means for implementing the functions specified in multiple blocks.

[0370] These computer program operations can also be loaded onto a computer or other programmable data processing device, such that a series of operation steps are executed on the computer or other programmable device to generate a computer-implemented process, and thus the operations executed on the computer or other programmable device provide steps for implementing the functions specified in one flow Figure 1 one flow or multiple flows and / or blocks Figure 1 or a means for implementing the functions specified in multiple blocks.

[0371] As mentioned above, the above are only the preferred embodiments of the present invention and are not used to limit the protection scope of the present invention. Any modifications, equivalent replacements, and improvements made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A sample analysis system, comprising: A blood cell analyzer for detecting at least one sample to obtain a detection result of the at least one sample; A control device for obtaining the detection result of the at least one sample; A smear preparation device for preparing a smear of a sample to be analyzed by a cell image analysis device to obtain a smear of the sample to be analyzed; A cell image analysis device for photographing and analyzing the smear of the sample to be analyzed to obtain a cell image and a cell image analysis result of the sample to be analyzed; The control device is further configured to: If at least one cell value in the detection result of the sample to be analyzed is less than a preset threshold, control the cell image analysis device to photograph the smear of the sample to be analyzed under a first photographing condition to obtain an image of the at least one cell; If at least one cell value in the detection result of the sample to be analyzed is not less than a preset threshold, control the cell image analysis device to photograph the smear of the sample to be analyzed under a second photographing condition different from the first photographing condition to obtain an image of the at least one cell; Wherein, the at least one cell value includes a value related to cell volume.

2. The sample analysis system according to claim 1, wherein, The at least one cell value includes the volume of white blood cells, red blood cells or platelets.

3. The sample analysis system according to any one of claims 1-2, wherein, The first photographing condition and the second photographing condition correspond to different focusing ranges.

4. The sample analysis system according to any one of claims 1-3, wherein, The focusing range corresponding to the second photographing condition is greater than the focusing range corresponding to the first photographing condition.

5. A sample analysis system, comprising: A blood cell analyzer for detecting at least one sample to obtain a detection result of the at least one sample; A control device for obtaining the detection result of the at least one sample; A smear preparation device for preparing a smear of a sample to be analyzed by a cell image analysis device to obtain a smear of the sample to be analyzed; A cell image analysis device for photographing and analyzing the smear of the sample to be analyzed to obtain a cell image and a cell image analysis result of the sample to be analyzed; The control device is further configured to: If at least one cell value in the detection result of the sample to be analyzed is less than a preset threshold, control the cell image analysis device to photograph the smear of the sample to be analyzed under a first photographing condition to obtain an image of the at least one cell; If at least one cell value in the detection result of the sample to be analyzed is not less than a preset threshold, control the cell image analysis device to photograph the smear of the sample to be analyzed under a second photographing condition different from the first photographing condition to obtain an image of the at least one cell; Wherein, the first photographing condition and the second photographing condition correspond to different photographing positions.

6. The sample analysis system according to claim 5, wherein, The at least one cell value includes the count value of platelets, and the control device is configured to: If the count value of platelets is less than a preset threshold, control the cell image analysis device to photograph the smear of the sample to be analyzed under a first photographing condition; If the count value of platelets is not less than a preset threshold, control the cell image analysis device to photograph the smear of the sample to be analyzed under a second photographing condition; Among them, the shooting positions corresponding to the first shooting condition include the tail and / or the edge of the smear; the shooting positions corresponding to the second shooting condition include the body part of the smear.

7. A sample analysis system, comprising: A blood cell analyzer for detecting at least one sample to obtain the detection result of the at least one sample; A control device for obtaining the detection result of the at least one sample; A smear preparation device for preparing a smear of a sample to be analyzed by a cell image analysis device to obtain a smear of the sample to be analyzed; A cell image analysis device for photographing and analyzing the smear of the sample to be analyzed to obtain the cell image and the cell image analysis result of the sample to be analyzed; The control device is further configured to select an analysis mode of the cell image analysis device according to at least one of the detection result of the sample to be analyzed and the sample information, and the shooting condition of the analysis mode is related to the detection result; the analysis mode includes at least one of a white blood cell analysis mode, a red blood cell analysis mode, and a platelet analysis mode or a combination of at least two or more modes; The control device is further configured to control the cell image analysis device to photograph the smear of the sample to be analyzed according to the selected analysis mode.

8. The sample analysis system according to claim 7, wherein, The shooting condition is related to at least one of the number of cell images taken, the shooting range, the shooting position, the magnification of the shooting objective lens, and the focusing range.

9. The sample analysis system according to any one of claims 7-8, wherein, The control device is further configured to select a shooting condition according to at least one cell value in the detection result of the sample to be analyzed, and the at least one cell value includes at least one of the number, volume, or proportion of the cells.

10. The sample analysis system according to any one of claims 7-9, wherein, The control device is configured to: If the detection result of the sample to be analyzed includes abnormal information related to white blood cells, select a white blood cell analysis mode or a combined mode including the white blood cell analysis mode; The control device is further configured to: If the abnormal information related to white blood cells is that the count value of white blood cells is lower than a first preset threshold or abnormal cells related to white blood cells, select the first shooting condition; If the count value of white blood cells in the sample to be analyzed is not lower than the first preset threshold and there are no abnormal cells related to white blood cells, select the second shooting condition; Among them, the number of white blood cell images taken corresponding to the first shooting condition is greater than the number of white blood cell images taken corresponding to the second shooting condition.

11. The sample analysis system according to any one of claims 7-9, wherein, The control device is configured to: If the detection result of the sample to be analyzed includes abnormal information related to red blood cells, select a red blood cell analysis mode or a combined mode including the red blood cell analysis mode; the abnormal information related to red blood cells includes at least one of red blood cell aggregation, red blood cell fragments, and the volume of red blood cells being less than a preset volume.

12. The sample analysis system according to claim 11, wherein, The control device is further configured to: If the abnormal information related to red blood cells includes red blood cell aggregation, control the cell image analysis device to photograph the tail of the smear.

13. The sample analysis system according to any one of claims 11-12, wherein, The control device is further configured to: If the volume of red blood cells (MCV) is less than the preset volume, control the cell image analysis device to perform a small-area red blood cell scan on the smear.

14. The sample analysis system according to any one of claims 7-9, wherein, The control device is configured to: If the detection result of the sample to be analyzed includes abnormal information related to platelets, a platelet analysis mode or a combined mode including the platelet analysis mode is selected; the abnormal information related to platelets includes at least one of platelet aggregation and a platelet count value lower than a second preset threshold; The control device is further configured to: If the count value of the platelets is lower than the second preset threshold, select a first shooting condition; If the count value of the platelets is not lower than the second preset threshold, select a second shooting condition; The shooting positions or shooting ranges corresponding to the first shooting condition and the second shooting condition are different.

15. The sample analysis system according to claim 14, wherein, The shooting range corresponding to the first shooting condition is larger than the shooting range corresponding to the second shooting condition; or The shooting position corresponding to the first shooting condition includes the tail and / or edge of the smear; the shooting position corresponding to the second shooting condition includes the body part of the smear.

16. The sample analysis system according to claim 7, wherein, The control device is further configured to: If the count values of white blood cells, hemoglobin concentration, and platelets in the detection result of the sample to be analyzed are all lower than the corresponding preset thresholds, select a simple mode that combines the white blood cell analysis mode, red blood cell analysis mode, and platelet analysis mode.

17. The sample analysis system according to claim 7, wherein, The control device is configured to: select an analysis mode according to the sample information; the selecting an analysis mode according to the sample information includes: if the sample information includes that the sample to be analyzed is from pediatrics and there is no information on previous medical records, select a simple mode that combines the white blood cell analysis mode, red blood cell analysis mode, and platelet analysis mode.

18. The sample analysis system according to claim 7, wherein, The control device is configured to: Judge whether preset abnormal information appears according to the detection result of the sample to be analyzed; If the first type of abnormal information appears, select a first shooting condition; If the second type of abnormal information appears, select a second shooting condition different from the first shooting condition.

19. The sample analysis system according to claim 18, wherein, The first type of abnormal information includes abnormal cell prompts or alarm information, and the first shooting condition includes selecting a first objective lens to shoot the smear of the sample to be analyzed; the second type of abnormal information includes information on abnormal cell classification ratios, and the second shooting condition includes selecting a second objective lens to shoot the smear of the sample to be analyzed; wherein, the magnification of the first objective lens is higher than that of the second objective lens.

20. The sample analysis system according to claim 18, wherein, The first type of abnormal information includes that the proportion of abnormal cells is less than a preset proportion, the second type of abnormal information includes that the proportion of abnormal cells is not less than the preset proportion, and the number of white blood cell images taken under the first shooting condition is less than the number of white blood cell images taken under the second shooting condition.

21. The sample analysis system according to any one of claims 7-20, wherein, The control device is further configured to: If the number of red blood cells is less than a preset threshold, select a white blood cell analysis mode or a combined mode including the white blood cell analysis mode, and the shooting condition of the white blood cell analysis mode is to shoot white blood cells and the junction of the body part and the tail of the smear.

22. A sample analysis system, comprising: A blood cell analyzer for detecting at least one sample to obtain the detection result of the at least one sample; A control device for obtaining the detection result of the at least one sample; A smear preparation device is used to prepare a smear of a sample to be analyzed by a cell image analysis device, so as to obtain a smear of the sample to be analyzed; A cell image analysis device is used to photograph and analyze the smear of the sample to be analyzed to obtain a cell image and a cell image analysis result of the sample to be analyzed; The control device is further configured to: if the detection result of the sample to be analyzed includes abnormal cells, adjust the cell positioning and the number of photographs according to the proportion of the abnormal cells.

23. The sample analysis system according to claim 22, wherein, The abnormal cells include nucleated red blood cells; the adjusting of the cell positioning and the number of photographs according to the proportion of the abnormal cells includes adjusting the positioning and the number of photographs of white blood cells according to the proportion of nucleated red blood cells. The higher the proportion of nucleated red blood cells, the more the positioning number of white blood cells.

24. The sample analysis system according to claim 22, wherein, The abnormal cells include neutrophils; the adjusting of the cell positioning and the number of photographs according to the proportion of the abnormal cells includes adjusting the positioning and the number of photographs of cells according to the proportion of neutrophils. The higher the proportion of neutrophils, the fewer the number of positioned and photographed cells; the lower the proportion of neutrophils, the more the number of positioned and photographed cells.

25. A blood cell analysis method includes: Obtaining the detection result of the sample to be analyzed; If the value related to the volume of at least one cell in the detection result is less than a preset threshold, controlling the cell image analysis device to photograph the smear of the sample to be analyzed under a first photographing condition to obtain an image of the at least one cell; If the value related to the volume of at least one cell in the detection result is not less than the preset threshold, controlling the cell image analysis device to photograph the smear of the sample to be analyzed under a second photographing condition different from the first photographing condition to obtain an image of the at least one cell.

26. The blood cell analysis method according to claim 25, wherein, The focusing range corresponding to the second photographing condition is greater than the focusing range corresponding to the first photographing condition.

27. A blood cell analysis method includes: Obtaining the detection result of the sample to be analyzed; If the platelet count value in the detection result is less than a preset threshold, controlling the cell image analysis device to photograph the smear of the sample to be analyzed under a first photographing condition to obtain an image of the at least one cell; If the platelet count value in the detection result is not less than the preset threshold, controlling the cell image analysis device to photograph the smear of the sample to be analyzed under a second photographing condition different from the first photographing condition to obtain an image of the at least one cell; Wherein, the photographing position corresponding to the first photographing condition includes the tail and / or the edge of the smear; the photographing position corresponding to the second photographing condition includes the body of the smear.

28. A blood cell analysis method includes: Obtaining the detection result of the sample to be analyzed and the sample information of the sample to be analyzed; Selecting an analysis mode of the cell image analysis device according to at least one of the detection result of the sample to be analyzed and the sample information of the sample to be analyzed. The analysis mode includes at least one mode or a combination of at least two or more modes among a white blood cell analysis mode, a red blood cell analysis mode, and a platelet analysis mode; The control cell image analysis device takes pictures of the smear of the sample to be analyzed according to the selected analysis mode.

29. The blood cell analysis method according to claim 28, wherein, The shooting conditions are related to at least one of the number of cell images taken, the shooting range, the shooting position, the magnification of the shooting objective lens, and the focusing range.

30. The blood cell analysis method according to any one of claims 28-29, wherein, The selection of the analysis mode of the cell image analysis device according to at least one of the detection result of the sample to be analyzed and the sample information of the sample to be analyzed includes: if the detection result of the sample to be analyzed includes abnormal information related to white blood cells, then select the white blood cell analysis mode or a combined mode including the white blood cell analysis mode; The shooting conditions of the white blood cell analysis mode include: if the abnormal information related to white blood cells is that the count value of white blood cells is lower than the first preset threshold or abnormal cells related to white blood cells, then the shooting conditions of the white blood cell analysis mode are the first shooting conditions; if the count value of white blood cells in the sample to be analyzed is not lower than the first preset threshold and there are no abnormal cells related to white blood cells, then the shooting conditions of the white blood cell analysis mode are the second shooting conditions; Wherein, the number of white blood cell images taken corresponding to the first shooting conditions is greater than the number of white blood cell images taken corresponding to the second shooting conditions.

31. The blood cell analysis method according to any one of claims 28-29, wherein, The selection of the analysis mode of the cell image analysis device according to at least one of the detection result of the sample to be analyzed and the sample information of the sample to be analyzed includes: if the detection result of the sample to be analyzed includes abnormal information related to red blood cells, then select the red blood cell analysis mode or a combined mode including the red blood cell analysis mode; the abnormal information related to red blood cells includes at least one of red blood cell aggregation, red blood cell fragments, and the volume of red blood cells being less than the preset volume.

32. The blood cell analysis method according to claim 31, wherein, The shooting conditions of the red blood cell analysis mode include: if the abnormal information related to red blood cells includes red blood cell aggregation, the shooting condition is to take pictures of the tail of the smear; Or, if the abnormal information related to red blood cells includes microcytes, the shooting condition is to perform a small-area red blood cell scan of the smear.

33. The blood cell analysis method according to any one of claims 28-29, wherein, The selection of the analysis mode of the cell image analysis device according to at least one of the detection result of the sample to be analyzed and the sample information of the sample to be analyzed includes: if the detection result of the sample to be analyzed includes abnormal information related to platelets, then select the platelet analysis mode or a combined mode including the platelet analysis mode; the abnormal information related to platelets includes at least one of platelet aggregation and the platelet count value being lower than the second preset threshold; The shooting conditions of the platelet analysis mode include: if the platelet count value is lower than the second preset threshold, the shooting condition is the first shooting condition; if the platelet count value is not lower than the second preset threshold, the shooting condition is the second shooting condition; Wherein, the shooting position or shooting range corresponding to the first shooting conditions is different from that corresponding to the second shooting conditions.

34. The blood cell analysis method according to claim 33, wherein, The shooting range corresponding to the first shooting conditions is greater than the shooting range corresponding to the second shooting conditions; or The shooting position corresponding to the first shooting conditions includes the tail and / or edge of the smear; the shooting position corresponding to the second shooting conditions includes the body of the smear.

35. The blood cell analysis method according to claim 28, wherein, The selection of the analysis mode of the cell image analysis device based on at least one of the detection result of the sample to be analyzed and the sample information of the sample to be analyzed includes: if the white blood cells, red blood cells and platelets in the detection result of the sample to be analyzed are all lower than the corresponding preset thresholds, select the simple mode that combines the white blood cell analysis mode, the red blood cell analysis mode and the platelet analysis mode; Or, if the sample information includes that the sample to be analyzed comes from pediatrics and there is no information on previous medical records, select the simple mode that combines the white blood cell analysis mode, the red blood cell analysis mode and the platelet analysis mode.

36. The blood cell analysis method according to claim 28, wherein, The shooting conditions of the analysis mode include: if the detection result of the sample to be analyzed shows the preset first abnormal information, the shooting condition is the first shooting condition; if the detection result of the sample to be analyzed shows the preset second abnormal information, the shooting condition is the second shooting condition different from the first shooting condition.

37. The blood cell analysis method according to claim 36, wherein, The first abnormal information includes abnormal cell prompt or alarm information, and the first shooting condition includes selecting the first objective lens to shoot the smear of the sample to be analyzed; the second abnormal information includes information on abnormal cell classification ratio, and the second shooting condition includes selecting the second objective lens to shoot the smear of the sample to be analyzed; where the magnification of the first objective lens is higher than that of the second objective lens; Or, the first abnormal information includes that the proportion of abnormal cells is less than the preset proportion, the second abnormal information includes that the proportion of abnormal cells is not less than the preset proportion, and the number of white blood cell images taken under the first shooting condition is less than the number of white blood cell images taken under the second shooting condition.

38. The blood cell analysis method according to claim 28, wherein, The selection of the analysis mode of the cell image analysis device based on at least one of the detection result of the sample to be analyzed and the sample information of the sample to be analyzed includes: if the number of red blood cells in the detection result is less than the preset threshold, select the white blood cell analysis mode or a combined mode including the white blood cell analysis mode, and the shooting condition of the white blood cell analysis mode is to shoot the white blood cells and the junction of the body and the tail of the smear.

39. A blood cell analysis method, including: Obtaining the detection result of the sample to be analyzed; If the detection result of the sample to be analyzed includes abnormal cells, adjusting the number of cell images taken according to the proportion of the abnormal cells; where the proportion of abnormal cells is positively or negatively correlated with the number of cell images taken.

40. A blood cell analysis method, including: Obtaining the detection result of the sample analyzed by a blood cell analyzer; Preparing a blood smear of the sample; If the detection result of the sample includes infected red blood cells; then controlling the cell image analysis device to shoot the area with a thicker blood film on the blood smear to detect whether there is malaria parasite; where, the area with a thicker blood film on the blood smear includes the body and the tail of the blood smear.

41. A sample analysis system, including: A blood cell analyzer for detecting at least one sample to obtain the detection result of the at least one sample; A control device for obtaining the detection result of the at least one sample; A smear preparation device for preparing a smear of a sample to be analyzed by a cell image analysis device to obtain a smear of the sample to be analyzed; A cell image analysis device for photographing and analyzing the smear of the sample to be analyzed to obtain a cell image and a cell image analysis result of the sample to be analyzed; The control device is further configured to: If at least one cell value in the detection result of the sample to be analyzed is less than a preset threshold, control the cell image analysis device to photograph the smear of the sample to be analyzed under a first photographing condition to obtain an image of the at least one cell; If at least one cell value in the detection result of the sample to be analyzed is not less than a preset threshold, control the cell image analysis device to photograph the smear of the sample to be analyzed under a second photographing condition different from the first photographing condition to obtain an image of the at least one cell; Wherein, the photographing range of the smear by the cell image analysis device under the first photographing condition is larger than that under the second photographing condition.

42. The sample analysis system according to claim 41, characterized in that, The at least one cell value includes at least one of the count value, volume, or proportion of at least one cell.

43. The sample analysis system according to claim 41, wherein The at least one cell value includes at least one of the count value of white blood cells, the count value of red blood cells, and the count value of platelets.

44. The sample analysis system according to claim 41 or 43, characterized in that, The at least one cell value includes the count value of white blood cells; when the count value of white blood cells is less than the preset threshold, the first photographing condition is to photograph the body and edge of the smear; when the count value of white blood cells is not less than the preset threshold, the second photographing condition is to photograph the body of the smear.

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