Compound feed for strengthening hematopoiesis and blood functions of pigs and preparation method of compound feed

Abstract

The invention discloses a compound feed for strengthening hematopoiesis and blood functions of pigs and a preparation method of the compound feed, and belongs to the technical field of feeds. The compound feed is prepared by mixing corn flour, rice bran, bean cakes, fish meal, a hematopoietic functional agent and water. The preparation method of the hematopoietic functional agent comprises the following steps: mixing palm oil, egg yolk lecithin, cholesterol and polyglycerol-10 polyricinoleate to obtain a material A; mixing a synergistic aid, a ferrous ion source, deionized water and sodium alginate, adding the material A, and homogenizing to obtain a material B; mixing whey protein isolate, quercetin and deionized water, treating, adding an adjusting auxiliary agent and sodium alginate, stirring, and hydrating to obtain a material C; the material B and the material C are mixed, homogenized and freeze-dried, and the hematopoietic functional agent is obtained. Therefore, the absorption and utilization efficiency of the pork pigs on the iron element is promoted, and the hematopoietic capacity of the pork pigs is improved on the whole.

Description

Technical Field

[0001] The present invention belongs to the technical field of feeds, and particularly relates to a compound feed for strengthening the hematopoietic and blood functions of pigs and a preparation method thereof. Background Art

[0002] In the fields of feeds and animal husbandry, in order to improve and solve problems such as the growth, health, and meat color of fattening pigs, people often add an appropriate amount of iron element to the feed in order to supplement the blood of pigs and improve this series of problems. Iron is an indispensable trace element in animals. It is a key component of hemoglobin and myoglobin, and is also closely related to the activity of most enzymes in cells. Iron element plays a crucial role in animals. It participates in the normal transportation process of oxygen in body tissues, thus directly affecting energy metabolism and protein metabolism in animals. However, simply supplementing iron element cannot achieve the effect of blood supplementation.

[0003] The current hematopoietic technology mainly focuses on the supply of iron sources, and there are many types of iron sources. However, at the cellular level, even if the intake and storage of iron are very sufficient, it may lead to a lack of iron element because iron cannot be effectively released or utilized. Ferrous iron source, as an iron agent that can be directly absorbed by the intestine, has weak stability and is easily oxidized. The oxidized iron source cannot be directly absorbed by the divalent metal transporter of the small intestinal mucosa and needs to rely on gastric acid to reduce part of the trivalent iron to divalent iron, which affects the digestion and absorption efficiency and prolongs the digestion time. It will cause the iron source to stay in the intestine, and the trivalent iron that is not reduced in time is easy to form insoluble iron hydroxide precipitation in the intestine and adhere to the intestinal wall, which not only reduces the absorption rate of iron, but also increases the intestinal burden and prolongs the digestion time.

[0004] In addition, other factors such as porphyrin and other substances will also affect the hematopoietic effect. The initiation of hematopoiesis at the bone marrow source, the synthesis of hemoglobin, the generation of red blood cells, etc. are systematic projects, and each link will affect the hematopoietic effect. Summary of the Invention

[0005] The purpose of the present invention is to provide a compound feed for strengthening the hematopoietic and blood functions of pigs and a preparation method thereof, which is used to promote the absorption and utilization efficiency of iron element by fattening pigs, and supplement a variety of nutrients to synergistically improve the physiological state of fattening pigs, so as to overall improve the hematopoietic ability of the body of fattening pigs.

[0006] The purpose of the present invention can be achieved by the following technical solutions: A preparation method of a compound feed for strengthening the hematopoietic and blood functions of pigs, the compound feed is prepared by mixing corn flour, rice bran, soybean cake, fish meal, hematopoietic function agent and water; The preparation method of the hematopoietic function agent includes the following steps: S1. Mix palm oil, egg yolk lecithin, cholesterol, and polyglyceryl-10 polyricinoleate to obtain Material A; S2. In a nitrogen atmosphere, mix a synergistic auxiliary agent, a ferrous ion source, deionized water, and sodium alginate, add the said Material A, and homogenize to obtain Material B; S3. Mix whey protein isolate, quercetin, and deionized water, adjust the pH to alkaline, continue stirring for 10 - 20 h, adjust the pH to neutral, add an adjustment auxiliary agent and sodium alginate, stir, and then hydrate overnight at 4 °C to obtain Material C; S4. Mix the said Material B and Material C, homogenize, and freeze-dry to obtain the hematopoietic function agent.

[0007] As a preferred technical solution of the present invention, the mass ratio of corn flour, rice bran, soybean cake, fish meal, hematopoietic function agent, and water is 60 - 80: 20 - 25: 15 - 20: 2 - 3: 0.5 - 0.7: 20 - 30.

[0008] As a preferred technical solution of the present invention, in step S1, the mass ratio of palm oil, egg yolk lecithin, cholesterol, and polyglyceryl-10 polyricinoleate is 70 - 80: 7 - 9: 2 - 4: 1 - 2.

[0009] As a preferred technical solution of the present invention, in step S2, the mass ratio of Material A, synergistic auxiliary agent, ferrous ion source, deionized water, and sodium alginate is 200 - 250: 1 - 2: 6 - 8: 90: 2 - 4.

[0010] As a preferred technical solution of the present invention, in step S3, the mass ratio of whey protein isolate, quercetin, deionized water, adjustment auxiliary agent, and sodium alginate is 4 - 6: 0.4 - 0.6: 85 - 95: 1 - 2: 0.25 - 0.55.

[0011] As a preferred technical solution of the present invention, in step S4, the mass ratio of Material B and Material C is 2 - 3: 7 - 8.

[0012] As a preferred technical solution of the present invention, the synergistic auxiliary agent includes vitamin A, vitamin D3, vitamin E, vitamin K3, thiamine, riboflavin, vitamin B6, vitamin B12, biotin, folic acid, niacin, pantothenic acid, copper methionine, zinc chloride, manganese chloride, potassium iodate, choline chloride, taurine, spinach extract, grape seed extract, yeast selenium, astragalus carbon, millettia extract, white peony extract, alfalfa extract.

[0013] As a preferred technical solution of the present invention, the ferrous ion source includes ferrous gluconate, ferrous lactate, ferrous glycinate, oat bran peptide ferrous chelate, ferrous succinate, ferrous saccharose.

[0014] As a preferred technical solution of the present invention, the conditioning adjuvant includes erythritol, glucose, sodium chloride, potassium chloride, extract of Dactylis glomerata, extract of Scenedesmus deserticola, extract of beetroot, extract of Herba Ephedrae, and extract of Ginkgo biloba.

[0015] The compound feed for strengthening the hematopoietic and blood functions of pigs prepared according to the above preparation method.

[0016] The beneficial effects of the present invention: The compound feed for strengthening the hematopoietic and blood functions of pigs and its preparation method disclosed by the present invention enable the components to act synergistically through the selection and content ratio of each raw material in the formula, activate the hematopoietic function of pigs, improve the absorption, utilization and conversion of hematopoietic nutrients, improve the growth and metabolic functions, enhance the hematopoietic activity of pigs, and thus promote weight gain; Furthermore, the present application sets up a multi-layer embedding structure to construct an antioxidant protection system to avoid the oxidation of the ferrous ion source and improve the absorption effect and absorption efficiency of pigs for the iron source; the inner embedding layer covering the ferrous source is constructed by the hydrophobic interaction and intermolecular force between egg yolk lecithin and cholesterol, enhancing the structural compactness and stability of the inner embedding layer, which has a protective effect on the ferrous source in gastric juice and avoids the content from being dissociated and oxidized into trivalent iron ions in the stomach; the outer embedding layer network structure is constructed by using whey protein isolate, and quercetin is introduced into the whey protein isolate embedding system. The biological activity of quercetin endows the embedding layer with antioxidant protection function and improves the stability of the embedding layer. At the same time, the addition of sodium alginate can reduce the osmotic pressure difference between the internal and external water phases and enhance the stability of the embedding structure; Furthermore, a synergistic adjuvant prepared by compounding multiple substances enhances the hematopoietic function. Among them, vitamin A regulates the expression of intestinal iron transporters, promotes the absorption of ferrous ions, and enhances the transport efficiency of iron in the blood; vitamin D3 indirectly enhances the transmembrane transport of iron; vitamin E, as an antioxidant, inhibits the oxidation of ferrous sources; vitamin K3 promotes hemoglobin assembly; B vitamins (thiamine, riboflavin, vitamin B6, vitamin B12, biotin, folic acid, niacin, pantothenic acid), as antioxidants, inhibit the oxidation of ferrous sources, while promoting the division and maturation of erythrocyte precursors, promoting heme synthesis, participating in the energy metabolism within erythrocytes, and enhancing the absorption and transport of iron; copper methionine promotes the hematopoietic function through metabolic regulation and the supply of methionine raw materials; supplementing trace elements (zinc chloride, manganese chloride, potassium iodate, choline chloride, taurine) improves cell activity, balances cell osmotic pressure, stabilizes cell membranes, protects red blood cells, and enhances immunity; adding spinach extract promotes the proliferation of red blood cells, helps promote the synthesis of hemoglobin, thereby enhancing the oxygen-carrying capacity of the blood; grape seed extract prolongs the lifespan of red blood cells and enhances the hematopoietic function; yeast selenium supplements the trace element selenium and enhances the antioxidant effect; the addition of Astragalus membranaceus carbon can prolong the residence time of the hematopoietic function agent in the intestine and improve the absorption effect; the addition of extracts of Caulis Spatholobi, Radix Paeoniae Alba, and Medicago sativa improves the enterohepatic circulation, promotes the reabsorption and transport of iron, promotes the hematopoietic function, and improves blood circulation; Astragalus membranaceus carbon and Radix Paeoniae Alba extract enhance the proliferation ability of hematopoietic stem cells and inhibit apoptosis by regulating cytokines; the compounding of grape seed extract, yeast selenium, Radix Paeoniae Alba extract, and Medicago sativa extract reduces the damage of red blood cell membranes, prolongs their circulation lifespan, and reduces the abnormal destruction of red blood cells in circulation; through the synergistic effect of each component, the hematopoietic function is enhanced; Furthermore, by adding a variety of substances to prepare the synergistic effect between the regulating adjuvant and the synergistic adjuvant, it helps regulate the production of red blood cells, ensures that the raw materials required for hemoglobin synthesis are sufficient, improves the efficiency of hematopoiesis, participates in various physiological metabolisms in the pig body, provides sufficient nutrients for the hematopoietic tissue, has antioxidant, regulates cell osmotic pressure, immunomodulates, improves microcirculation and other effects, directly or indirectly strengthens the hematopoietic function; maintains the ion concentration gradient on both sides of the cell membrane through the sodium-potassium pump, maintains the stability of the red blood cell membrane potential; adds glucose to provide energy for the hematopoietic stem cells, red blood cell precursors and other cells with vigorous proliferation, and ensures the osmotic pressure of the cells. The synthesis and function of pressure-regulating related proteins are stabilized, and erythritol is added to form an osmotic barrier outside the cells to prevent excessive water from penetrating into the cells, avoid sudden changes in osmotic pressure caused by fluctuations in glucose concentration, and work together with glucose to maintain dynamic balance; through the compatibility of duckweed extract, desert algae extract, beetroot extract, green radish flower extract, and ginkgo leaf extract, it delays water loss, enhances osmotic pressure buffering capacity, optimizes the water-salt balance of the hematopoietic microenvironment, dilates blood vessels, improves bone marrow blood flow, promotes the transport of electrolytes and osmotic pressure regulating substances, maintains the permeability balance of capillaries to electrolytes, and promotes circulation in the body. DETAILED DESCRIPTION

[0017] In order to further illustrate the technical means and effects adopted by the present invention to achieve the predetermined purpose of the invention, the specific implementation methods, structures, features and effects of the present invention are described in detail below in combination with the embodiments.

[0018] Example 1 A method for preparing a compound feed for enhancing pig hematopoiesis and blood function, wherein the compound feed is prepared by mixing 60 kg cornmeal, 20 kg rice bran, 15 kg soybean cake, 2 kg fish meal, 0.5 kg hematopoietic function agent and 20 kg water; The preparation method of the hematopoietic function agent comprises the following steps: S1, palm oil, egg yolk lecithin, cholesterol and polyglycerol-10 polyricinoleate are mixed to obtain material A; the mass ratio of the palm oil, egg yolk lecithin, cholesterol and polyglycerol-10 polyricinoleate is 70:7:2:1; S2. In a nitrogen atmosphere, a synergist, a ferrous ion source, deionized water, and sodium alginate were mixed evenly, and the material A was added. The mixture was sheared and homogenized at a speed of 10,000 r / min for 2 min to obtain material B; the mass ratio of the material A, synergist, ferrous ion source, deionized water, and sodium alginate was 200:1:6:90:2; S3. Mix whey protein isolate, quercetin, and deionized water, and stir magnetically for 2 h. Adjust the pH to 9 using a buffer solution prepared by mixing 0.1 mol / L sodium carbonate solution and 0.1 mol / L sodium bicarbonate solution in a volume ratio of 1:9. Continue stirring for 10 h, then adjust the pH to neutral using 0.1 mol / L acetic acid solution. Add the adjustment auxiliary agent and sodium alginate, stir for 2 h, and then hydrate overnight at 4 °C to obtain Material C; the mass ratio of the whey protein isolate, quercetin, deionized water, adjustment auxiliary agent, and sodium alginate is 4:0.4:85:1:0.25; S4. Mix Material B and Material C, shear and homogenize at a speed of 10,000 r / min for 2 min, and then freeze-dry at -40 °C for 10 h to obtain the hematopoietic function agent; the mass ratio of Material B to Material C is 2:7.

[0019] The synergistic auxiliary agent includes 3500 IU of vitamin A, 500 IU of vitamin D3, 15 IU of vitamin E, 1 mg of vitamin K3, 5 mg of thiamine, 2.5 mg of riboflavin, 0.5 mg of vitamin B6, 2 mg of vitamin B12, 0.7 mg of biotin, 0.5 mg of folic acid, 10 mg of niacin, 5 mg of pantothenic acid, 15 mg of copper methionine, 100 mg of zinc chloride, 20 mg of manganese chloride, 0.5 mg of potassium iodate, 150 mg of choline chloride, 20 mg of taurine, 30 mg of spinach extract, 20 mg of grape seed extract, 0.3 mg of yeast selenium, 5 mg of astragalus carbon, 15 mg of millettia extract, 15 mg of white peony extract, 10 mg of alfalfa extract.

[0020] The ferrous ion source includes 30 parts by mass of ferrous gluconate, 10 parts by mass of ferrous lactate, 6 parts by mass of ferrous glycinate, 5 parts by mass of oat bran peptide ferrous chelate, 20 parts by mass of ferrous succinate, and 8 parts by mass of ferrous saccharate.

[0021] The adjustment auxiliary agent includes 22 parts by mass of erythritol, 25 parts by mass of glucose, 15 parts by mass of sodium chloride, 15 parts by mass of potassium chloride, 8 parts by mass of dactylis glomerata extract, 5 parts by mass of scenedesmus deserticola extract, 5 parts by mass of beet root extract, 3 parts by mass of epipremnum aureum flower extract, and 1 part by mass of ginkgo biloba extract.

[0022] Example 2 A preparation method of a compound feed for strengthening the hematopoietic and blood functions of pigs, the compound feed is prepared by mixing 70 kg of corn flour, 23 kg of rice bran, 18 kg of soybean cake, 2.5 kg of fish meal, 0.6 kg of hematopoietic function agent, and 25 kg of water; The preparation method of the hematopoietic function agent includes the following steps: S1. Mix palm oil, egg yolk lecithin, cholesterol and polyglycerol-10 polyricinoleate to obtain Material A; the mass ratio of palm oil, egg yolk lecithin, cholesterol and polyglycerol-10 polyricinoleate is 75:8:3:1.5; S2. In a nitrogen atmosphere, take a synergistic adjuvant, a ferrous ion source, deionized water, and sodium alginate, mix them evenly, add the Material A, and perform shear homogenization at a rotation speed of 11000 r / min for 2.5 min to obtain Material B; the mass ratio of Material A, synergistic adjuvant, ferrous ion source, deionized water, and sodium alginate is 225:1.5:7:90:3; S3. Take whey protein isolate, quercetin, and deionized water, mix them, stir magnetically for 2.5 h, adjust the pH to 9 using a buffer solution prepared by mixing 0.1 mol / L sodium carbonate solution and 0.1 mol / L sodium bicarbonate solution in a volume ratio of 1:9, continue stirring for 15 h, adjust the pH to neutral using 0.1 mol / L acetic acid solution, add a conditioning adjuvant and sodium alginate, stir for 3 h, and then hydrate overnight at 4 °C to obtain Material C; the mass ratio of whey protein isolate, quercetin, deionized water, conditioning adjuvant, and sodium alginate is 5:0.5:90:1.5:0.4; S4. Take the Material B and Material C, mix them, perform shear homogenization at a rotation speed of 11000 r / min for 2.5 min, and perform freeze-drying treatment at -40 °C for 15 h to obtain the hematopoietic function agent; the mass ratio of Material B and Material C is 2.5:7.5.

[0023] The synergistic adjuvant includes 3500 IU of vitamin A, 500 IU of vitamin D3, 15 IU of vitamin E, 1 mg of vitamin K3, 5 mg of thiamine, 2.5 mg of riboflavin, 0.5 mg of vitamin B6, 2 mg of vitamin B12, 0.7 mg of biotin, 0.5 mg of folic acid, 10 mg of niacin, 5 mg of pantothenic acid, 15 mg of copper methionine, 100 mg of zinc chloride, 20 mg of manganese chloride, 0.5 mg of potassium iodate, 150 mg of choline chloride, 20 mg of taurine, 35 mg of spinach extract, 25 mg of grape seed extract, 0.3 mg of yeast selenium, 6 mg of astragalus carbon, 18 mg of millettia extract, 18 mg of white peony extract, 12 mg of alfalfa extract.

[0024] The ferrous ion source includes 35 parts by mass of ferrous gluconate, 13 parts by mass of ferrous lactate, 7 parts by mass of ferrous glycinate, 6 parts by mass of oat bran peptide ferrous chelate, 24 parts by mass of ferrous succinate, and 9 parts by mass of ferrous sucrose.

[0025] The conditioning adjuvant includes 22 parts by mass of erythritol, 25 parts by mass of glucose, 15 parts by mass of sodium chloride, 15 parts by mass of potassium chloride, 9 parts by mass of Dactylis glomerata extract, 6 parts by mass of Scenedesmus deserticola extract, 6 parts by mass of beet root extract, 4 parts by mass of Epipremnum aureum flower extract, and 1.2 parts by mass of Ginkgo biloba extract.

[0026] Example 3 A preparation method of a compound feed for strengthening the hematopoietic and blood functions of pigs, the compound feed is prepared by mixing 80 kg of corn flour, 25 kg of rice bran, 20 kg of soybean cake, 3 kg of fish meal, 0.7 kg of hematopoietic function agent and 30 kg of water; The preparation method of the hematopoietic function agent includes the following steps: S1. Mix palm oil, egg yolk lecithin, cholesterol and polyglycerol-10 polyricinoleate to obtain material A; the mass ratio of palm oil, egg yolk lecithin, cholesterol and polyglycerol-10 polyricinoleate is 80:9:4:2; S2. In a nitrogen atmosphere, take a synergistic adjuvant, a ferrous ion source, deionized water, and sodium alginate and mix them evenly, add the material A, and shear and homogenize at a rotation speed of 12,000 r / min for 3 min to obtain material B; the mass ratio of material A, synergistic adjuvant, ferrous ion source, deionized water, and sodium alginate is 250:2:8:90:4; S3. Mix whey protein isolate, quercetin, and deionized water, stir magnetically for 3 h, adjust the pH to 9 using a buffer solution prepared by mixing 0.1 mol / L sodium carbonate solution and 0.1 mol / L sodium bicarbonate solution in a volume ratio of 1:9, continue stirring for 20 h, adjust the pH to neutral using 0.1 mol / L acetic acid solution, add a conditioning adjuvant and sodium alginate, stir for 4 h, and then hydrate overnight at 4°C to obtain material C; the mass ratio of whey protein isolate, quercetin, deionized water, conditioning adjuvant, and sodium alginate is 6:0.6:95:2:0.55; S4. Mix the material B and the material C, shear and homogenize at a rotation speed of 12,000 r / min for 3 min, and perform freeze-drying treatment at -40°C for 20 h to obtain the hematopoietic function agent; the mass ratio of material B and material C is 3:8.

[0027] The synergistic adjuvant includes 3500 IU of vitamin A, 500 IU of vitamin D3, 15 IU of vitamin E, 1 mg of vitamin K3, 5 mg of thiamine, 2.5 mg of riboflavin, 0.5 mg of vitamin B6, 2 mg of vitamin B12, 0.7 mg of biotin, 0.5 mg of folic acid, 10 mg of niacin, 5 mg of pantothenic acid, 15 mg of copper methionine, 100 mg of zinc chloride, 20 mg of manganese chloride, 0.5 mg of potassium iodate, 150 mg of choline chloride, 20 mg of taurine, 40 mg of spinach extract, 30 mg of grape seed extract, 0.3 mg of yeast selenium, 7 mg of astragalus carbon, 20 mg of millettia reticulata extract, 20 mg of paeonia lactiflora extract, and 15 mg of alfalfa extract.

[0028] The ferrous ion source includes 40 parts by mass of ferrous gluconate, 16 parts by mass of ferrous lactate, 8 parts by mass of ferrous glycinate, 7 parts by mass of ferrous chelate of oat bran peptide, 28 parts by mass of ferrous succinate, and 10 parts by mass of ferrous saccharate.

[0029] The regulating adjuvant includes 22 parts by mass of erythritol, 25 parts by mass of glucose, 15 parts by mass of sodium chloride, 15 parts by mass of potassium chloride, 10 parts by mass of dactylis glomerata extract, 7 parts by mass of scenedesmus deserticola extract, 7 parts by mass of beet root extract, 5 parts by mass of herba meyerbati extract, and 1.5 parts by mass of ginkgo biloba extract.

[0030] Comparative Example 1 The difference from Example 2 is that the preparation method of the hematopoietic function agent includes the following steps: Take the synergistic adjuvant, ferrous ion source, deionized water, and regulating adjuvant in accordance with the formula amounts, mix them, and perform shear homogenization at a rotation speed of 11000 r / min for 2.5 min to obtain the hematopoietic function agent.

[0031] Comparative Example 2 The difference from Example 2 is that the preparation method of the hematopoietic function agent includes the following steps: In a nitrogen atmosphere, take the synergistic adjuvant, ferrous ion source, deionized water, and sodium alginate in accordance with the formula amounts, mix them evenly, add Material A, and perform shear homogenization at a rotation speed of 11000 r / min for 2.5 min to obtain the hematopoietic function agent.

[0032] Comparative Example 3 The difference from Example 2 is that vitamin B12 is not added to the synergistic adjuvant, and the remaining operation steps and parameters remain unchanged.

[0033] Comparative Example 4 The difference from Example 2 is that copper methionine is not added to the synergistic adjuvant, and the remaining operation steps and parameters remain unchanged.

[0034] Comparative Example 5 The difference from Example 2 is that taurine is not added to the synergistic auxiliary agent, and the remaining operation steps and parameters remain unchanged.

[0035] Comparative Example 6 The difference from Example 2 is that spinach extract is not added to the synergistic auxiliary agent, and the remaining operation steps and parameters remain unchanged.

[0036] Comparative Example 7 The difference from Example 2 is that grape seed extract is not added to the synergistic auxiliary agent, and the remaining operation steps and parameters remain unchanged.

[0037] Comparative Example 8 The difference from Example 2 is that yeast selenium is not added to the synergistic auxiliary agent, and the remaining operation steps and parameters remain unchanged.

[0038] Comparative Example 9 The difference from Example 2 is that astragalus carbon is replaced with astragalus powder of the same mass in the synergistic auxiliary agent, and the remaining operation steps and parameters remain unchanged.

[0039] Comparative Example 10 The difference from Example 2 is that millettia extract is not added to the synergistic auxiliary agent, and the remaining operation steps and parameters remain unchanged.

[0040] Comparative Example 11 The difference from Example 2 is that white peony root extract is not added to the synergistic auxiliary agent, and the remaining operation steps and parameters remain unchanged.

[0041] Comparative Example 12 The difference from Example 2 is that alfalfa extract is not added to the synergistic auxiliary agent, and the remaining operation steps and parameters remain unchanged.

[0042] Comparative Example 13 The difference from Example 2 is that dactylis glomerata extract is not added to the regulation auxiliary agent, and the remaining operation steps and parameters remain unchanged.

[0043] Comparative Example 14 The difference from Example 2 is that scenedesmus deserticola extract is not added to the regulation auxiliary agent, and the remaining operation steps and parameters remain unchanged.

[0044] Comparative Example 15 The difference from Example 2 is that beet root extract is not added to the regulation auxiliary agent, and the remaining operation steps and parameters remain unchanged.

[0045] Comparative Example 16 The difference from Example 2 is that herba ipomoeae turpethum extract is not added to the regulation auxiliary agent, and the remaining operation steps and parameters remain unchanged.

[0046] Comparative Example 17 It is different from Example 2 in that ginkgo leaf extract is not added to the conditioning adjuvant, and the remaining operation steps and parameters remain unchanged.

[0047] Comparative Example 18 It is different from Example 2 in that the conditioning adjuvant is not added during the preparation process of step S3.

[0048] Performance Test Select 15 healthy Landrace piglets at 7 weeks of age with similar body weights. Divide them into a control group, Example 1 group, Example 2 group, Example 3 group, Comparative Example 1 group, Comparative Example 2 group, Comparative Example 3 group, Comparative Example 4 group, Comparative Example 5 group, Comparative Example 6 group, Comparative Example 7 group, Comparative Example 8 group, Comparative Example 9 group, Comparative Example 10 group, Comparative Example 11 group, Comparative Example 12 group, Comparative Example 13 group, Comparative Example 14 group, Comparative Example 15 group, Comparative Example 16 group, Comparative Example 17 group, and Comparative Example 18 group.

[0049] Control group: Feed the formulated feed prepared in Example 2 without hematopoietic function agent in the diet.

[0050] The remaining test groups are respectively fed the formulated feeds prepared in the corresponding examples.

[0051] The test pigs are all raised in loose pens, with a feeding area of 10 m 2 ² for each pig, free drinking water, free activities, and fed seven times a day (06:00, 08:00, 10:00, 12:00, 14:00, 16:00, 18:00).

[0052] During the 1st - 30th day of the test, 0.5 kg of formulated feed is fed each time; during the 31st - 60th day of the test, 1.5 kg of formulated feed is fed each time; during the 61st - 100th day of the test, 3 kg of formulated feed is fed each time.

[0053] To study the effect of the formulated feed of the present invention on the growth performance of pigs, the fasting body weights of each group of pigs in the control group, Examples 1 - 3, and Comparative Examples 1 - 18 are measured on the 1st day and 100th day of the test period before morning feeding; at the same time, blood is collected from the ear edge vein, and the blood of the pigs is collected before the test and 1 day before the end of the test. The hemoglobin content is detected by a portable hemoglobin detector, and the test results are shown in Table 1.

[0054] Table 1 As can be seen from Table 1, the formulated feeds prepared in Examples 1 - 3 of the present application can enhance the hematopoietic activity of pigs, promote growth, and are beneficial to weight gain compared with the control group and each comparative example.

[0055] The above are only the preferred embodiments of the present invention, and there is no limitation to the present invention in any form. Although the present invention has been disclosed above with the preferred embodiments, it is not intended to limit the present invention. Any person skilled in the art can make some changes or modifications to equivalent embodiments of equivalent changes within the scope of the technical solution of the present invention by using the technical content disclosed above. However, as long as it does not depart from the content of the technical solution of the present invention, any brief modifications, equivalent changes and modifications made to the above embodiments based on the technical essence of the present invention still fall within the scope of the technical solution of the present invention.

Claims

1. A preparation method of a compound feed for enhancing the hematopoietic and blood functions of pigs, characterized in that, The compound feed is prepared by mixing corn flour, rice bran, soybean cake, fish meal, hematopoietic function agent and water; The preparation method of the hematopoietic function agent comprises the following steps: S1. Mix palm oil, egg yolk lecithin, cholesterol and polyglycerol-10 polyricinoleate to obtain material A; S2. In a nitrogen atmosphere, take a synergistic auxiliary agent, a ferrous ion source, deionized water and sodium alginate, mix them, add the material A, and homogenize to obtain material B; S3. Mix whey protein isolate, quercetin and deionized water, adjust the pH to alkaline, continue stirring for 10-20 h, adjust the pH to neutral, add an adjustment auxiliary agent and sodium alginate, stir, and hydrate overnight at 4°C to obtain material C; S4. Mix the material B and the material C, homogenize, and freeze-dry to obtain the hematopoietic function agent.

2. The preparation method of a compound feed for enhancing the hematopoiesis and blood function of pigs according to claim 1, characterized in that, The mass ratio of the corn flour, rice bran, soybean cake, fish meal, hematopoietic function agent and water is 60-80:20-25:15-20:2-3:0.5-0.7:20-30.

3. The preparation method of a compound feed for enhancing the hematopoiesis and blood function of pigs according to claim 1, characterized in that, In step S1, the mass ratio of the palm oil, egg yolk lecithin, cholesterol and polyglycerol-10 polyricinoleate is 70-80:7-9:2-4:1-2.

4. The preparation method of a compound feed for enhancing the hematopoietic and blood functions of pigs according to claim 1, characterized in that, In step S2, the mass ratio of the material A, the synergistic auxiliary agent, the ferrous ion source, deionized water and sodium alginate is 200-250:1-2:6-8:90:2-4.

5. The preparation method of a compound feed for enhancing the hematopoietic and blood functions of pigs according to claim 1, characterized in that, In step S3, the mass ratio of the whey protein isolate, quercetin, deionized water, the adjustment auxiliary agent and sodium alginate is 4-6:0.4-0.6:85-95:1-2:0.25-0.

55.

6. The preparation method of a compound feed for enhancing the hematopoietic and blood functions of pigs according to claim 1, characterized in that, In step S4, the mass ratio of the material B and the material C is 2-3:7-8.

7. The preparation method of a compound feed for enhancing the hematopoietic and blood functions of pigs according to claim 1, characterized in that, The synergistic auxiliary agent includes vitamin A, vitamin D3, vitamin E, vitamin K3, thiamine, riboflavin, vitamin B6, vitamin B12, biotin, folic acid, niacin, pantothenic acid, copper methionine, zinc chloride, manganese chloride, potassium iodate, choline chloride, taurine, spinach extract, grape seed extract, yeast selenium, astragalus carbon, millettia extract, white peony extract, alfalfa extract.

8. The preparation method of a compound feed for enhancing the hematopoiesis and blood function of pigs according to claim 1, characterized in that, The ferrous ion source includes ferrous gluconate, ferrous lactate, ferrous glycinate, oat bran peptide ferrous chelate, ferrous succinate, ferrous saccharose.

9. The preparation method of a compound feed for enhancing the hematopoietic and blood functions of pigs according to claim 1, characterized in that The adjustment auxiliary agent includes erythritol, glucose, sodium chloride, potassium chloride, dactylis glomerata extract, scenedesmus deserticola extract, beet root extract, herba ipomoeae turpethum extract, ginkgo biloba extract.

10. A compound feed for strengthening the hematopoietic and blood functions of pigs prepared by the preparation method according to any one of claims 1-9.

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