A staple peptide with antibacterial activity and its application
By modifying the structure of SLP-0, a staple peptide was prepared, which solved its hemolytic problem and significantly improved its antibacterial activity against a variety of bacteria, showing potential for application as a novel antibacterial drug.
CN120383667BActive Publication Date: 2026-03-13SHANDONG FIRST MEDICAL UNIV & SHANDONG ACADEMY OF MEDICAL SCI
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2024-08-05
- Publication Date
- 2026-03-13
AI Technical Summary
Technical Problem
The existing antimicrobial peptide SLP-0 has hemolytic problems, which limits its further development and application.
Method used
By structurally modifying SLP-0 and replacing specific amino acid residues, staple peptides can be prepared. For example, Lys can be used to replace 1L, 4V, 5W, 8V, 9F, 11L, 12L, 15Y, 16W, 19L, 22P, or 23V in Ac-LKRVWKRVFKLLKS5YWRS5LKKPVR-NH2 to form stable staple peptides.
Benefits of technology
The hemolytic activity of the staple peptide was improved, and its antibacterial activity against Streptococcus pneumoniae, methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumoniae was significantly enhanced, showing promising application potential as a novel antibacterial drug.
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Smart Images
Figure CN120383667B_ABST
Abstract
This invention belongs to the field of peptide drugs, specifically relating to a staple peptide with antibacterial activity and its applications. Using Ac-LKRVWKRVFKLLKS5YWRS5LKKPVR-NH2 as a peptide template, the amino acid residue 11L is replaced by K to obtain the target staple peptide SLP-6. The obtained staple peptide SLP-6 exhibits significantly improved hemolytic activity compared to the template peptide.
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Citation Information
Patent Citations
Antibacterial stapling peptide as well as preparation method and application thereof
CN117486994A