High-breathability pressure-sensitive adhesive based on medical label adhesive tape and preparation method of high-breathability pressure-sensitive adhesive

Abstract

The invention relates to the technical field of pressure-sensitive adhesives, and discloses a high-breathability pressure-sensitive adhesive based on a medical label adhesive tape and a preparation method of the high-breathability pressure-sensitive adhesive. Comprising the following operation steps: step 1, sequentially adding an acrylic monomer and a vinyl metal organic framework material into a mixed solvent, uniformly mixing, adding an initiator, reacting at 70-75 DEG C for 2-3 hours, adding allyl polyethylene glycol, and continuously reacting for 3-5 hours; evaporating to remove the solvent to obtain modified acrylate resin; and 2, mixing and homogenizing the modified acrylate resin, the tackifying resin, vitamin E and the solvent to obtain the high-permeability pressure-sensitive adhesive.

Description

Technical Field

[0001] The present invention relates to the technical field of pressure - sensitive adhesives, and specifically to a highly breathable pressure - sensitive adhesive based on medical label tapes and a preparation method thereof. Background Art

[0002] In the medical field, medical label tapes play an important role. They can be used to fix various medical devices, monitoring instruments, and identify patient information, etc. And the pressure - sensitive adhesive is a key component of medical label tapes, and its performance directly affects the use effect of the tape and the comfort of patients. Traditional pressure - sensitive adhesives used in medical label tapes have the problem of poor air permeability. When pasted on the skin for a long time, it will hinder the normal breathing of the skin and the discharge of sweat, resulting in adverse reactions such as skin redness, itching, and allergy.

[0003] Currently, in the preparation process of some pressure - sensitive adhesives with air permeability, the synergistic effect between various components is not fully considered. When the pressure - sensitive adhesive obtains air permeability, other important properties are sacrificed, such as peel strength, etc. For example, in the prior art, in order to improve air permeability, some pressure - sensitive adhesives overly reduce the thickness of the adhesive layer or reduce the content of the sticky component, resulting in the tape being prone to falling off during use and unable to meet the requirements of medical applications.

[0004] In summary, it is of great significance to prepare a highly breathable pressure - sensitive adhesive based on medical label tapes. Summary of the Invention

[0005] The purpose of the present invention is to provide a highly breathable pressure - sensitive adhesive based on medical label tapes and a preparation method thereof to solve the problems raised in the prior art.

[0006] To achieve the above - mentioned purpose, the present invention provides the following technical solutions: A preparation method of a highly breathable pressure - sensitive adhesive based on medical label tapes, comprising the following operating steps: Step 1: Add acrylic monomers and vinyl - based metal - organic framework materials to a mixed solvent in sequence and mix evenly. Add an initiator and react at 70 - 75 °C for 2 - 3 hours. Then add allyl polyethylene glycol and continue to react for 3 - 5 hours. Evaporate the solvent to obtain a modified acrylate resin. Step 2: Mix and homogenize the modified acrylate resin, tackifying resin, vitamin E, and solvent to obtain a highly breathable pressure - sensitive adhesive.

[0007] Preferably, the raw materials of the highly breathable pressure - sensitive adhesive include the following components: by mass, 60 - 70 parts of modified acrylate resin, 12 - 17 parts of tackifying resin, 0.15 - 0.2 parts of vitamin E, and 35 - 45 parts of solvent; the solvent includes one or more of acetone, ethyl acetate, and toluene.

[0008] More preferably, the raw materials of the modified acrylate resin include the following components: by mass, 50 to 75 parts of acrylic monomers, 0.5 to 1.2 parts of vinyl metal-organic framework material, 10 to 12 parts of allyl polyethylene glycol, and 100 to 120 parts of a mixed solvent; the mixed solvent includes acetone and ethyl acetate with a mass ratio of 1:(1 to 2).

[0009] More preferably, the molecular weight of the allyl polyethylene glycol is 1000 to 2000.

[0010] More preferably, the acrylic monomers include the following components: 35 to 50 parts of isooctyl acrylate, 8 to 12 parts of methyl methacrylate, 5 to 7 parts of acrylic acid, and 3 to 4 parts of hydroxypropyl acrylate.

[0011] More preferably, the preparation method of the vinyl metal-organic framework material is as follows: (1) 1,4-dibromobenzene, 3,4-dimethoxyphenylboronic acid, and sodium carbonate are added to an aqueous solution of tetrahydrofuran and mixed evenly, degassed three times, and tetrakis(triphenylphosphine)palladium is added under a nitrogen atmosphere, and the mixture is refluxed at 70 to 75 °C for 15 to 20 hours. After cooling to room temperature, it is purified to obtain an intermediate; (2) the intermediate and methyl eugenol are added to dichloromethane, and boron tribromide-dichloromethane solution is added under an ice-water bath condition, and the reaction is carried out at room temperature for 8 to 12 hours, quenched with cold water, and purified to obtain a ligand; (3) copper nitrate hydrate is added to deionized water and mixed evenly to obtain an aqueous solution of copper nitrate hydrate; the ligand is added to DMF and mixed evenly, the aqueous solution of copper nitrate hydrate is added, and ultrasonic treatment is carried out for 10 to 15 minutes, and the mixture is heated at 85 to 90 °C for 20 to 30 hours, cooled to room temperature, filtered, washed, and dried to obtain the vinyl metal-organic framework material.

[0012] More preferably, the raw materials of the intermediate include the following components: by mass, 1 to 1.2 parts of 1,4-dibromobenzene, 1.3 to 1.32 parts of 3,4-dimethoxyphenylboronic acid, 0.3 to 0.7 parts of sodium carbonate, 0.17 to 0.2 parts of tetrakis(triphenylphosphine)palladium, and 40 to 60 parts of an aqueous solution of tetrahydrofuran; the tetrahydrofuran accounts for 80 to 85 wt% of the aqueous solution of tetrahydrofuran; The mass ratio of the boron tribromide-dichloromethane solution, the intermediate, and methyl eugenol is (3 to 4):(0.2 to 0.3):0.1; the concentration of the boron tribromide-dichloromethane solution is 1 to 1.3 M; the mass ratio of the copper nitrate hydrate to the ligand is (1 to 1.2):1.

[0013] More preferably, the tackifying resin includes glycerol ester of rosin and terpene resin with a mass ratio of 1:(3 to 4).

[0014] Compared with the prior art, the beneficial effects of the present invention are: In this solution, isooctyl acrylate (soft monomer), methyl methacrylate (hard monomer), acrylic acid and hydroxypropyl acrylate (functional monomers), and polyethylene glycol are made into a modified acrylate resin under certain conditions; and it is homogenized with a tackifying resin and vitamin E (antioxidant) to make a highly breathable pressure-sensitive adhesive.

[0015] In order to improve the air permeability effect of the pressure-sensitive adhesive; in the solution, introducing polyethylene glycol can increase the flexibility and mobility of the modified acrylate resin; enabling the promotion of gas diffusion between molecular chains and improving the gas permeability; the long chain of polyethylene glycol can effectively reduce the crystallinity of the molecular chain and increase the interfacial wettability, thereby improving the adhesion of the highly breathable pressure-sensitive adhesive.

[0016] The addition of the tackifying resin can increase the viscosity of the pressure-sensitive adhesive, but it will reduce the air permeability effect of the pressure-sensitive adhesive; in the solution, in order not to reduce the viscosity and air permeability effect, a metal-organic framework material is introduced into the modified acrylate resin, thereby improving the air permeability of the pressure-sensitive adhesive.

[0017] In the solution, 1,4-dibromobenzene and 3,4-dimethoxyphenylboronic acid undergo a Suzuki coupling reaction, and then a demethylation reaction is carried out together with methyleugenol to obtain a ligand containing a catechol group; then the ligand and copper ions are stirred under certain conditions for coordination to obtain an ethylene-based metal-organic framework material; among them, the coordination of the organic framework structure containing catechol and copper ions helps to improve the air permeability and, to a certain extent, improve the water resistance of the pressure-sensitive adhesive, enabling it to maintain good performance in a humid environment or when in contact with water. Specific implementation manners

[0018] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative efforts belong to the scope of protection of the present invention.

[0019] In the following specific embodiments, "parts" refer to parts by mass. In this embodiment, it should be noted that there are no special restrictions on the manufacturers from which the raw materials involved in the present invention are purchased. Exemplarily, these include: the CAS number of isooctyl acrylate is 29590-42-9; the CAS number of methyl methacrylate is 80-62-6; the CAS number of acrylic acid is 79-10-7; the CAS number of hydroxypropyl acrylate is 25584-83-2; the product number of methyleugenol is F-21, food grade, purchased from Shandong Aicai Biotechnology Co., Ltd.; the CAS number of AIBN initiator is 78-67-1; the product number of allyl polyethylene glycol (molecular weight 1500) is 27274-31-3, purchased from Chongqing Ruiya Biotechnology Co., Ltd.; the CAS number of 1,4-dibromobenzene is 106-37-6; the CAS number of 3,4-dimethoxybenzeneboronic acid is 122775-35-3; the CAS number of sodium carbonate is 497-19-8; the CAS number of tetrakis(triphenylphosphine)palladium is 14221-01-3; the CAS number of boron tribromide is 10294-33-4; the CAS number of copper nitrate hydrate is 13478-38-1, product number js2024122611, purchased from Wuhan Jushun Chemical Co., Ltd.; vitamin E is food grade, purchased from Leshengyuan Biotechnology (Nanjing) Co., Ltd.; the CAS number of glycerol rosinate is 8016-36-2, food grade, purchased from Wuhan Jiyesheng Chemical Co., Ltd.; the CAS number of terpene resin is 9003-74-1, pharmaceutical grade, purchased from Hubei Baidu Chemistry Co., Ltd.

[0020] Example 1: A preparation method of a highly breathable pressure-sensitive adhesive based on a medical label tape, comprising the following operating steps: Step 1: 40 parts of isooctyl acrylate, 12 parts of methyl methacrylate, 7 parts of acrylic acid, 4 parts of hydroxypropyl acrylate, and 0.5 part of vinyl metal-organic framework material are sequentially added to a mixed solvent (the mass ratio of acetone to ethyl acetate is 1:1) and mixed evenly. An initiator is added, and the reaction is carried out at 75°C for 2 hours. Then 10 parts of allyl polyethylene glycol are added, and the reaction continues for 3 hours; the solvent is evaporated to obtain a modified acrylate resin. Step 2: 60 parts of the modified acrylate resin, 12 parts of tackifying resin, 0.2 part of vitamin E, and 40 parts of solvent (the mass ratio of acetone to ethyl acetate is 1:1) are mixed and homogenized to obtain a highly breathable pressure-sensitive adhesive. Among them, the preparation method of the vinyl metal-organic framework material: (1) 1 part of 1,4-dibromobenzene, 1.3 parts of 3,4-dimethoxyphenylboronic acid, and 1.5 parts of sodium carbonate are added to 45 parts of an aqueous tetrahydrofuran solution (tetrahydrofuran accounts for 80 wt% of the aqueous tetrahydrofuran solution), and they are uniformly mixed. After degassing three times, 0.17 part of tetrakis(triphenylphosphine)palladium is added under a nitrogen atmosphere, and the mixture is refluxed at 70 °C for 18 hours. After cooling to room temperature, ethyl acetate is added, and it is washed 4 times with deionized water. The organic layers are combined, dried with anhydrous magnesium sulfate, filtered and rotary evaporated, purified by silica gel chromatography, dissolved in ethyl acetate, and n-hexane is added dropwise for recrystallization to obtain an intermediate; (2) The boron tribromide-dichloromethane solution and the intermediate are weighed according to a mass ratio of 3.5:0.2:0.1; the intermediate and methyl eugenol are added to dichloromethane, and a 1 M boron tribromide-dichloromethane solution is added under an ice-water bath condition, and the reaction is carried out at room temperature for 10 hours, quenched with cold water, stirred for 30 minutes, filtered and washed. The solid is added to methanol, and dichloromethane and n-hexane are added dropwise for precipitation, filtered and washed 4 times, and dried to obtain a ligand; (3) Copper nitrate hydrate is added to deionized water and uniformly mixed to obtain an aqueous copper nitrate hydrate solution; the ligand is added to DMF and uniformly mixed, and the aqueous copper nitrate hydrate solution is added, and ultrasonic treatment is carried out for 15 minutes, heated at 85 °C for 25 hours, cooled to room temperature, filtered, washed 4 times, and dried to obtain the vinyl metal-organic framework material; the mass ratio of copper nitrate hydrate to the ligand is 1.2:1.

[0021] Example 2: A preparation method of a highly breathable pressure-sensitive adhesive based on a medical label tape, comprising the following operating steps: Step 1: 40 parts of isooctyl acrylate, 12 parts of methyl methacrylate, 7 parts of acrylic acid, 4 parts of hydroxypropyl acrylate, and 1.2 parts of vinyl metal-organic framework material are sequentially added to a mixed solvent (the mass ratio of acetone to ethyl acetate is 1:1), uniformly mixed, an initiator is added, and the reaction is carried out at 75 °C for 2 hours. 12 parts of allyl polyethylene glycol are added, and the reaction is continued for 3 hours; the solvent is distilled off to obtain a modified acrylate resin; Step 2: 65 parts of the modified acrylate resin, 12 parts of a tackifying resin, 0.2 part of vitamin E, and 40 parts of a solvent (the mass ratio of acetone to ethyl acetate is 1:1) are mixed and homogenized to obtain a highly breathable pressure-sensitive adhesive; Among them, the preparation method of the vinyl metal-organic framework material: (1) 1 part of 1,4-dibromobenzene, 1.3 parts of 3,4-dimethoxyphenylboronic acid, and 1.5 parts of sodium carbonate are added to 45 parts of a tetrahydrofuran aqueous solution (tetrahydrofuran accounts for 80 wt% of the tetrahydrofuran aqueous solution) and mixed evenly. After degassing three times, 0.17 part of tetrakis(triphenylphosphine)palladium is added under a nitrogen atmosphere, and the mixture is refluxed at 70 °C for 18 hours. After cooling to room temperature, ethyl acetate is added, and it is washed 4 times with deionized water. The organic layers are combined, dried with anhydrous magnesium sulfate, filtered and rotary evaporated, purified by silica gel chromatography, dissolved in ethyl acetate, and n-hexane is added dropwise for recrystallization to obtain an intermediate; (2) The boron tribromide-dichloromethane solution and the intermediate are weighed according to a mass ratio of 3.5:0.2:0.1; the intermediate and methyl eugenol are added to dichloromethane, and a 1 M boron tribromide-dichloromethane solution is added under an ice-water bath condition, and the reaction is carried out at room temperature for 10 hours, quenched with cold water, stirred for 30 minutes, filtered and washed. The solid is added to methanol, and dichloromethane and n-hexane are added dropwise for precipitation, filtered and washed 4 times, and dried to obtain a ligand; (3) Copper nitrate hydrate is added to deionized water and mixed evenly to obtain an aqueous solution of copper nitrate hydrate; the ligand is added to DMF and mixed evenly, and the aqueous solution of copper nitrate hydrate is added, and ultrasonic treatment is carried out for 15 minutes, heated at 85 °C for 25 hours, cooled to room temperature, filtered, washed 4 times, and dried to obtain the vinyl metal-organic framework material; the mass ratio of copper nitrate hydrate to the ligand is 1.2:1.

[0022] Example 3: A preparation method of a highly breathable pressure-sensitive adhesive based on a medical label tape, comprising the following operating steps: Step 1: 40 parts of isooctyl acrylate, 12 parts of methyl methacrylate, 7 parts of acrylic acid, 4 parts of hydroxypropyl acrylate, and 0.8 part of vinyl metal-organic framework material are sequentially added to a mixed solvent (the mass ratio of acetone to ethyl acetate is 1:1) and mixed evenly. An initiator is added, and the reaction is carried out at 75 °C for 2 hours. 10 parts of allyl polyethylene glycol are added, and the reaction continues for 3 hours; the solvent is evaporated to obtain a modified acrylate resin; Step 2: Mix 70 parts of modified acrylate resin, 12 parts of tackifying resin, 0.2 part of vitamin E, and 40 parts of solvent (the mass ratio of acetone to ethyl acetate is 1:1) and homogenize to obtain a highly breathable pressure-sensitive adhesive. Preparation method of vinyl metal-organic framework material: (1) Add 1 part of 1,4-dibromobenzene, 1.3 parts of 3,4-dimethoxyphenylboronic acid, and 1.5 parts of sodium carbonate to 45 parts of a tetrahydrofuran aqueous solution (tetrahydrofuran accounts for 80 wt% of the tetrahydrofuran aqueous solution), mix evenly, perform degassing three times, add 0.17 part of tetrakis(triphenylphosphine)palladium under a nitrogen atmosphere, reflux at 70 °C for 18 hours, cool to room temperature, add ethyl acetate, wash with deionized water 4 times, combine the organic layers, add anhydrous magnesium sulfate for drying, filter and rotary evaporate, purify by silica gel chromatography, add to ethyl acetate for dissolution, and dropwise add n-hexane for recrystallization to obtain an intermediate; (2) Weigh the boron tribromide-dichloromethane solution and the intermediate according to a mass ratio of 3.5:0.2:0.1; Add the intermediate and methyl eugenol to dichloromethane, add 1 M boron tribromide-dichloromethane solution under an ice-water bath condition, react at room temperature for 10 hours, quench with cold water, stir for 30 minutes, filter and wash, add the solid to methanol, dropwise add dichloromethane and n-hexane for precipitation, filter and wash 4 times, and dry to obtain a ligand; (3) Add copper nitrate hydrate to deionized water and mix evenly to obtain a copper nitrate hydrate aqueous solution; Add the ligand to DMF and mix evenly, add the copper nitrate hydrate aqueous solution, ultrasonically treat for 15 minutes, heat at 85 °C for 25 hours, cool to room temperature, filter, wash 4 times, and dry to obtain a vinyl metal-organic framework material; The mass ratio of copper nitrate hydrate to the ligand is 1.2:1.

[0023] Comparative Example 1 is based on Example 2, without adding a metal-organic framework material, and the remaining steps are the same; Step 1: Add 40 parts of isooctyl acrylate, 12 parts of methyl methacrylate, 7 parts of acrylic acid, and 4 parts of hydroxypropyl acrylate to a mixed solvent (the mass ratio of acetone to ethyl acetate is 1:1) in sequence, mix evenly, add an initiator, react at 75 °C for 2 hours, add 12 parts of allyl polyethylene glycol, and continue to react for 3 hours; Evaporate the solvent to obtain a modified acrylate resin; Step 2: Mix 65 parts of modified acrylate resin, 12 parts of tackifying resin, 0.2 part of vitamin E, and 40 parts of solvent (the mass ratio of acetone to ethyl acetate is 1:1) and homogenize to obtain a highly breathable pressure-sensitive adhesive.

[0024] Comparative Example 2 is based on Example 2, without adding polyethylene glycol, and the remaining steps are the same; Step 1: Add 40 parts of isooctyl acrylate, 12 parts of methyl methacrylate, 7 parts of acrylic acid, 4 parts of hydroxypropyl acrylate, and 1.2 parts of vinyl metal-organic framework material into a mixed solvent (the mass ratio of acetone to ethyl acetate is 1:1) in sequence, mix evenly, add an initiator, react at 75 °C for 2 hours, add 12 parts of allyl polyethylene glycol, and continue to react for 3 hours; evaporate the solvent to obtain a modified acrylate resin; Step 2: Mix and homogenize 65 parts of the modified acrylate resin, 12 parts of tackifying resin, 0.2 part of vitamin E, and 40 parts of solvent (the mass ratio of acetone to ethyl acetate is 1:1) to obtain a highly breathable pressure-sensitive adhesive.

[0025] Comparative Example 3 is based on Example 2, with the addition amount of vinyl metal-organic framework material increased, and the remaining steps are the same; Step 1: Add 40 parts of isooctyl acrylate, 12 parts of methyl methacrylate, 7 parts of acrylic acid, 4 parts of hydroxypropyl acrylate, and 5 parts of vinyl metal-organic framework material into a mixed solvent (the mass ratio of acetone to ethyl acetate is 1:1) in sequence, mix evenly, add an initiator, react at 70 °C for 2 hours, add 12 parts of allyl polyethylene glycol, and continue to react for 3 hours; evaporate the solvent to obtain a modified acrylate resin; Step 2: Mix and homogenize 65 parts of the modified acrylate resin, 12 parts of tackifying resin, 0.2 part of vitamin E, and 40 parts of solvent (the mass ratio of acetone to ethyl acetate is 1:1) to obtain a highly breathable pressure-sensitive adhesive.

[0026] Comparative Example 4 is based on Example 2, without coordination; the remaining steps are the same; Step 1: Add 40 parts of isooctyl acrylate, 12 parts of methyl methacrylate, 7 parts of acrylic acid, 4 parts of hydroxypropyl acrylate, and 1.2 parts of ligand into a mixed solvent (the mass ratio of acetone to ethyl acetate is 1:1) in sequence, mix evenly, add an initiator, react at 75 °C for 2 hours, add 12 parts of allyl polyethylene glycol, and continue to react for 3 hours; evaporate the solvent to obtain a modified acrylate resin; Step 2: Mix and homogenize 65 parts of the modified acrylate resin, 12 parts of tackifying resin, 0.2 part of vitamin E, and 40 parts of solvent (the mass ratio of acetone to ethyl acetate is 1:1) to obtain a highly breathable pressure-sensitive adhesive; Among them, the preparation method of the ligand: (1) 1 part of 1,4-dibromobenzene, 1.3 parts of 3,4-dimethoxyphenylboronic acid, and 1.5 parts of sodium carbonate are added to 45 parts of a tetrahydrofuran aqueous solution (tetrahydrofuran accounts for 80 wt% of the tetrahydrofuran aqueous solution) and mixed evenly. After degassing three times, 0.17 part of tetrakis(triphenylphosphine)palladium is added under a nitrogen atmosphere, and the mixture is refluxed at 70 °C for 18 hours. After cooling to room temperature, ethyl acetate is added, and it is washed 4 times with deionized water. The organic layers are combined, dried with anhydrous magnesium sulfate, filtered and rotary evaporated, purified by silica gel chromatography, dissolved in ethyl acetate, and n-hexane is added dropwise for recrystallization to obtain an intermediate; (2) The boron tribromide-dichloromethane solution and the intermediate are weighed according to a mass ratio of 3.5:0.2:0.1; the intermediate and methyl eugenol are added to dichloromethane, and a 1 M boron tribromide-dichloromethane solution is added under an ice-water bath condition, and the reaction is carried out at room temperature for 10 hours, quenched with cold water, stirred for 30 minutes, filtered and washed. The solid is added to methanol, and dichloromethane and n-hexane are added dropwise for precipitation, filtered and washed 4 times, and dried to obtain the ligand.

[0027] Comparative Example 5 is based on Example 2, and the molecular weight of polyethylene glycol (molecular weight 600) is reduced; the remaining steps are the same; Step 1: 40 parts of isooctyl acrylate, 12 parts of methyl methacrylate, 7 parts of acrylic acid, 4 parts of hydroxypropyl acrylate, and 1.2 parts of vinyl metal-organic framework material are sequentially added to a mixed solvent (the mass ratio of acetone to ethyl acetate is 1:1) and mixed evenly. An initiator is added, and the reaction is carried out at 75 °C for 2 hours. Then 12 parts of allyl polyethylene glycol are added, and the reaction continues for 3 hours; the solvent is evaporated to obtain a modified acrylate resin; Step 2: 65 parts of the modified acrylate resin, 12 parts of tackifying resin, 0.2 part of vitamin E, and 40 parts of solvent (the mass ratio of acetone to ethyl acetate is 1:1) are mixed and homogenized to obtain a highly breathable pressure-sensitive adhesive.

[0028] Detection test: 1. The highly breathable pressure-sensitive adhesives prepared in Examples 1 to 3 and Comparative Examples 1 to 5 are respectively mixed evenly with Bayer 3100 crosslinking agent, coated on a non-woven fabric tape base layer, and baked in an oven at 120 °C for 30 s to obtain a medical label tape, which is cut into 150 mm × 25 mm for subsequent tests; among them, the mass ratio of the highly breathable pressure-sensitive adhesive to the crosslinking agent is 100:0.21; the thickness of the non-woven fabric tape base layer is 20 μm, and the thickness of the highly breathable pressure-sensitive adhesive layer is 10 μm; 2. The medical label tape obtained above is pasted on the surface of a stainless steel plate (already cleaned), and a pressure roller is used to roll it 3 times along the length direction of the specimen at a speed of about 60 cm / min. There are no bubbles between the medical label tape and the steel plate. Then it is respectively soaked in deionized water at 25 °C for 12 hours, and a 180° peel strength test is carried out according to GB / T 2792-2014; the test is repeated 3 times and the average value is calculated; 3. Apply the medical label tapes prepared in Examples 1 to 3 and Comparative Examples 1 to 5 onto the skin of the arm for 6 hours, and observe the skin condition after peeling. Table 1 Peeling strength (N / 25mm) Skin condition Example 1 13.3 No abnormality Example 2 13.8 No abnormality Example 3 13.6 No abnormality Comparative example 1 12.7 No abnormality Comparative example 2 12.3 Slight wrinkling Comparative example 3 14.2 Slight redness Comparative example 4 15.1 Slight wrinkling Comparative example 5 13.0 No abnormality Conclusion: Comparative Example 1 is based on Example 2 without adding vinyl metal-organic framework material, resulting in a decrease in the water resistance of the highly breathable pressure-sensitive adhesive and thus a decline in the performance of the medical label tape. Comparative Example 2 is based on Example 2 without adding polyethylene glycol, leading to a decrease in the viscosity and breathability of the highly breathable pressure-sensitive adhesive, and thus slight wrinkling and a reduction in mechanical properties. Comparative Example 3 is based on Example 2 with an increased addition amount of vinyl metal-organic framework material. Although the water resistance is improved, slight redness appears. Comparative Example 4 is based on Example 2 without coordination, resulting in an increase in the number of catechol structures in the highly breathable pressure-sensitive adhesive, enhancing the bonding with the steel plate and leading to an increase in the peel strength. However, the breathability is reduced, thus causing slight wrinkling of the skin. Comparative Example 5 is based on Example 2 with a reduced molecular weight of polyethylene glycol, thus resulting in a decline in the performance of the medical label tape.

[0029] For those skilled in the art, it is obvious that the present invention is not limited to the details of the above exemplary embodiments, and the present invention can be implemented in other specific forms without departing from the spirit or basic characteristics of the present invention. Therefore, from any point of view, the embodiments should be regarded as exemplary and non-limiting. The scope of the present invention is defined by the appended claims rather than the above description. Therefore, all changes falling within the meaning and scope of the equivalent elements of the claims are intended to be encompassed by the present invention.

Claims

1. A preparation method of a highly breathable pressure-sensitive adhesive based on a medical label tape, characterized in that: It includes the following operating steps: Step 1: Add acrylic monomers and vinyl metal-organic framework materials to a mixed solvent in sequence and mix evenly. Add an initiator, react at 70 - 75 °C for 2 - 3 hours, add allyl poly(ethylene glycol), and continue to react for 3 - 5 hours; evaporate the solvent to obtain a modified acrylate resin; Step 2: Mix and homogenize the modified acrylate resin, tackifying resin, vitamin E, and solvent to obtain a highly breathable pressure-sensitive adhesive.

2. The preparation method of a highly breathable pressure-sensitive adhesive based on a medical label tape according to claim 1, wherein: The raw materials of the highly breathable pressure-sensitive adhesive include the following components: by mass, 60 - 70 parts of modified acrylate resin, 12 - 17 parts of tackifying resin, 0.15 - 0.2 part of vitamin E, and 35 - 45 parts of solvent; the solvent includes one or more of acetone, ethyl acetate, and toluene.

3. The preparation method of a highly breathable pressure-sensitive adhesive based on a medical label tape according to claim 1, wherein: The raw materials of the modified acrylate resin include the following components: by mass, 50 - 75 parts of acrylic monomers, 0.5 - 1.2 parts of vinyl metal-organic framework, 10 - 12 parts of allyl poly(ethylene glycol), and 100 - 120 parts of mixed solvent; the mixed solvent includes acetone and ethyl acetate with a mass ratio of 1:(1 - 2).

4. The preparation method of a highly breathable pressure-sensitive adhesive based on a medical label tape according to claim 1, characterized in that: The molecular weight of the allyl poly(ethylene glycol) is 1000 - 2000.

5. The preparation method of a highly breathable pressure-sensitive adhesive based on a medical label tape according to claim 1, characterized in that: The acrylic monomers include the following components: 35 - 50 parts of 2-ethylhexyl acrylate, 8 - 12 parts of methyl methacrylate, 5 - 7 parts of acrylic acid, and 3 - 4 parts of hydroxypropyl acrylate.

6. The preparation method of a highly breathable pressure-sensitive adhesive based on a medical label tape according to claim 1, characterized in that: The preparation method of the vinyl metal-organic framework material is as follows: (1) Add 1,4-dibromobenzene, 3,4-dimethoxyphenylboronic acid, and sodium carbonate to an aqueous tetrahydrofuran solution and mix evenly. Perform three degassing operations, add tetrakis(triphenylphosphine)palladium under a nitrogen atmosphere, reflux at 70 - 75 °C for 15 - 20 hours, cool to room temperature, and purify to obtain an intermediate; (2) Add the intermediate and methyl eugenol to dichloromethane, add boron tribromide-dichloromethane solution under an ice-water bath condition, react at room temperature for 8 - 12 hours, quench with cold water, and purify to obtain a ligand; (3) Add copper(II) nitrate trihydrate to deionized water and mix evenly to obtain an aqueous copper(II) nitrate trihydrate solution; add the ligand to DMF and mix evenly, add the aqueous copper(II) nitrate trihydrate solution, perform ultrasonic treatment for 10 - 15 minutes, heat at 85 - 90 °C for 20 - 30 hours, cool to room temperature, filter, wash, and dry to obtain the vinyl metal-organic framework material.

7. The preparation method of a highly breathable pressure-sensitive adhesive based on a medical label tape according to claim 6, wherein: The raw materials of the intermediate include the following components: by mass, 1 - 1.2 parts of 1,4-dibromobenzene, 1.3 - 1.32 parts of 3,4-dimethoxyphenylboronic acid, 0.3 - 0.7 part of sodium carbonate, 0.17 - 0.2 part of tetrakis(triphenylphosphine)palladium, and 40 - 60 parts of aqueous tetrahydrofuran solution; the tetrahydrofuran accounts for 80 - 85 wt% of the aqueous tetrahydrofuran solution; The mass ratio of the boron tribromide-dichloromethane solution, intermediate, and methyl eugenol is (3 - 4):(0.2 - 0.3):0.1; the concentration of the boron tribromide-dichloromethane solution is 1 - 1.3 M; the mass ratio of the copper(II) nitrate trihydrate to the ligand is (1 - 1.2):

1.

8. The preparation method of a highly breathable pressure-sensitive adhesive based on a medical label tape according to claim 1, characterized in that: The tackifying resin includes glycerol ester of rosin and terpene resin with a mass ratio of 1:(3 - 4).

9. A highly breathable pressure-sensitive adhesive is prepared by the preparation method of a highly breathable pressure-sensitive adhesive based on a medical label tape according to any one of claims 1 to 8.