Linoleic acid soft capsule and preparation method thereof

Abstract

The invention provides a linoleic acid soft capsule and a preparation method thereof, and relates to the technical field of soft capsule preparation. The linoleic acid soft capsule comprises a soft capsule shell and a soft capsule content, and the preparation method comprises the following steps: preparing a glue solution, namely heating and mixing carrageenan-bletilla striata polysaccharide mixed glue and water at 80 DEG C, then adding hydroxypropyl methyl cellulose, octenyl succinic acid modified starch, a plasticizer and an opacifying agent, uniformly stirring, treating by a homogenizer, and ultrasonically removing bubbles to obtain viscous shell sol; preparing a content: heating conjugated linoleic acid, vitamin E, a stabilizer and an emulsifier in parts by weight to 50-60 DEG C, stirring and mixing, cooling to room temperature, and treating by a homogenizer to obtain a content emulsion; and preparing the shell sol and the content emulsion into a soft capsule according to the dosage ratio through a capsule filling machine, and drying to obtain the soft capsule. The technology fills up the market vacancy of the novel conjugated linoleic acid soft capsule taking the suaeda salsa seed oil as the raw material, the raw materials are wide in source and easy to obtain, the enterprise cost is reduced, and the preparation method is simple, efficient and more suitable for industrial production.

Description

Technical Field

[0001] The present invention relates to the technical field of soft capsule preparation, and particularly to a conjugated linoleic acid soft capsule and a preparation method thereof. Background Art

[0002] Conjugated linoleic acid is a general term for a class of 18-carbon fatty acids containing conjugated double bonds, which has the functions of reducing blood lipid, softening blood vessels, lowering blood pressure, and promoting microcirculation, and has the health care effect of preventing and treating atherosclerosis and cardiovascular diseases, and has the reputation of "vascular scavenger".

[0003] Conjugated linoleic acid is rare in nature and exists in small amounts in animal fats and dairy products. The content of linoleic acid in the seed oil of Suaeda salsa is as high as more than 70%, which is an excellent raw material for preparing conjugated linoleic acid. Suaeda salsa is widely distributed in the wild in the Bohai Rim region and inland saline-alkali lands. Only the Suaeda salsa growing naturally in Dongying City can produce 17,100 tons of Suaeda salsa seed oil every year. However, there is no report on the application research of conjugated linoleic acid in Suaeda salsa seeds at present, and there is a lack of related products in the market, which is difficult to meet the demand for conjugated linoleic acid by people. Therefore, developing a new type of conjugated linoleic acid soft capsule using Suaeda salsa seed oil as the raw material not only fills the market gap, but also has a wide and easily available raw material source, can reduce the production cost of enterprises, and can promote the development and utilization of coastal wasteland. Summary of the Invention

[0004] The purpose of the present invention is to provide a conjugated linoleic acid soft capsule directly edible using Suaeda salsa seed oil as the raw material and a preparation method thereof. The raw material of Suaeda salsa seeds for this method is easily available, the preparation process is simple, efficient, and easy to realize industrial production, and can reduce the production cost of enterprises.

[0005] To this end, the technical solution of the present invention is that a conjugated linoleic acid soft capsule is prepared from a soft capsule shell and a soft capsule content; the preparation raw materials of the soft capsule shell, by weight, include: carrageenan-bletilla striata polysaccharide mixed gum 40-80 parts, hydroxypropyl methylcellulose 20-50 parts, octenyl succinic anhydride starch ester 20-50 parts, plasticizer 5-20 parts, light-shielding agent 0.01-0.1 part, and water 150-250 parts; the content, by weight, includes: conjugated linoleic acid 100-150 parts, vitamin E 0.01-1 part, stabilizer 0.05-0.2 part, emulsifier 0.2-1 part; the conjugated linoleic acid uses Suaeda salsa seeds as the raw material.

[0006] Further, the preparation method of the conjugated linoleic acid is as follows:

[0007] (1) Extracting Suaeda salsa seed oil: Open the extraction tank and load the pre-treated crushed Suaeda salsa seeds. Seal the equipment. Turn on the vacuum pump to put the whole system in a vacuum state. Close the valve at the liquid outlet of the extraction tank. Inject the extractant into the extraction tank in the form of subcritical fluid through a metering pump. The pressure and temperature during the extraction process are automatically reached and maintained by the control system according to the set values. After reaching the extraction time, open the valve at the liquid outlet of the extraction tank. The solvent enters the separation tank. Turn on the compressor. The extraction liquid is continuously vaporized and condensed into a liquid state after compression, and then flows back to the solvent storage tank. Finally, obtain Suaeda salsa seed oil from the separation tank;

[0008] (2) Take the Suaeda salsa seed oil and place it in glycerol. Add the catalyst NaOH. After heating and stirring in an oil bath at 180 °C for the conjugation reaction to end, obtain a conjugated linoleate solution;

[0009] (3) Acidify the conjugated linoleate solution to obtain fatty acids. Wash with distilled water until neutral, and dehydrate under vacuum to obtain conjugated linoleic acid.

[0010] Further, in the steps of the above preparation method of conjugated linoleic acid, the mesh number of the crushed Suaeda salsa seeds is 40 - 80 meshes; the extractant is No. 4 solvent; the temperature during the extraction process is 40 - 60 °C; the extraction time is 2 - 3 h.

[0011] Further, the mass ratio of the soft capsule shell to the soft capsule content is 1:1 - 1:3.

[0012] Further, the ratio of carrageenan - Bletilla striata polysaccharide mixed gum is 10:1 - 5:1.

[0013] Further, the plasticizer is one or a combination of glycerol, sorbitol, xylitol, etc.

[0014] Further, the opacifier is one or a combination of brilliant blue, lemon yellow, sunset yellow, and titanium dioxide.

[0015] Further, the stabilizer is any one of butylated hydroxyanisole, dibutylhydroxytoluene, ascorbyl palmitate, and tea polyphenol palmitate.

[0016] Further, the emulsifier is one or more of hydroxylated lecithin, sorbitan monostearate, and propylene glycol fatty acid ester;

[0017] A preparation method of conjugated linoleic acid soft capsules, using the above raw material ratio of conjugated linoleic acid soft capsules, includes the following steps:

[0018] (1) Preparation of the gelatin solution: Heat and mix the carrageenan - Bletilla striata polysaccharide mixed gum with water at 80 °C, then slowly add hydroxypropyl methylcellulose, octenyl succinic anhydride starch ester, plasticizer, and opacifier, stir evenly, process with a homogenizer, and remove air bubbles by ultrasonic to obtain a viscous shell sol;

[0019] (2) Content configuration: According to parts by weight, conjugate linoleic acid, vitamin E, stabilizer, and emulsifier are heated to 50 - 60 °C and stirred and mixed, then cooled to room temperature, and processed by a homogenizer to obtain the content emulsion;

[0020] (3) The shell sol and the content emulsion are made into soft capsules through a capsule filling machine according to the dosage ratio, and dried to obtain the conjugated linoleic acid soft capsules.

[0021] The beneficial effects of the present invention are that the conjugated linoleic acid soft capsule product prepared by the present invention has good properties, good data in all aspects, and stable process, which proves the feasibility of the process of making soft capsules with Suaeda salsa conjugated linoleic acid as the main raw material. The method is simple and efficient, and is more suitable for industrial production. It not only fills the market gap of the new conjugated linoleic acid soft capsules with Suaeda salsa seeds as the raw material, but also can promote the development and utilization of coastal wasteland. Description of the Drawings

[0022] Figure 1 is a schematic structural diagram of the Suaeda salsa seed oil extraction system in the present invention;

[0023] Figure 2 is the process flow chart of the Suaeda salsa seed oil extraction process in the present invention.

[0024] Symbol description in the figure:

[0025] 1. Extraction tank; 11. Filter device; 2. Separation tank; 3. Solvent tank; 4. Vacuum pump; 5. Compressor; 6. Condenser; 7. Chiller; 8. Metering pump; 9. Circulation pump. Specific Embodiments

[0026] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0027] As Figure 1 - Figure 2 shown, the present invention provides a Suaeda salsa seed oil extraction system, which includes an extraction tank 1, a separation tank 2, a solvent tank 3, a vacuum pump 4, a compressor 5, and a condenser 6. Pressure gauges and safety valves are installed on the extraction tank 1, the separation tank 2, and the solvent tank 3 to facilitate the display and control of the pressure in the tank. A filter device 11 is provided at the bottom of the extraction tank 1. For example, the filter device 11 is a stainless steel mesh, and the aperture is selected according to the filtering process requirements (such as 80 meshes) to intercept solid particles and allow the solvent to pass through.

[0028] The liquid inlet of the extraction tank 1 is connected to the solvent tank 3 through a pipeline in series with a metering pump 8 and a solenoid valve. The liquid outlet of the extraction tank 1 is connected to the liquid inlet of the separation tank 2 through a pipeline in series with a circulation pump 9 and a solenoid valve. A solenoid valve-controlled oil drain port is provided below the separation tank 2. The gas outlet of the separation tank 2 is connected to a vacuum pump 4 and a compressor 5 through a pipeline in series with a solenoid valve. The compressor 5 is connected to the reflux port of the solvent tank 3 through a condenser 6. The condenser 6 is connected to a chiller 7 through a circulation pipeline.

[0029] An oil extraction system for Suaeda salsa seeds further includes a heating / cooling system for adjusting the temperatures of the extraction tank 1 and the separation tank 2 (such as 30 - 80 °C) through a jacket or coiled pipe; a pressure system for adjusting the pressure by pressurizing with an inert gas (such as nitrogen) or a pressure reducing valve to maintain a subcritical state; and a control system integrating a PLC or DCS for real-time monitoring of parameters such as the temperature, pressure, and liquid level of the extraction tank 1, the separation tank 2, and the solvent tank 3.

[0030] The method for extracting oil from Suaeda salsa seeds is as follows: Open the extraction tank 1 and load the pre-treated crushed Suaeda salsa seeds with a mesh size of 40 - 80 meshes. Seal the equipment. Open the vacuum pump 4 to put the whole system in a vacuum state (system pressure drops to ≤ -0.08 MPa). Close the solenoid valve at the liquid outlet of the extraction tank 1. Inject the extraction agent, No. 4 solvent, into the extraction tank 1 through the metering pump 8 in the form of a subcritical fluid (temperature ≤ 50 °C, pressure 0.4 - 0.8 MPa). The solvent injection volume is 3 - 5 times the volume of the raw material. Stop when the liquid level reaches 80% of the tank body. During the extraction process, the pressure and temperature are automatically reached and maintained at 40 - 60 °C by the control system according to the set values. Turn on the stirring device with a rotation speed of 20 - 50 rpm to promote full contact between the solvent and the raw material. After reaching the extraction time of 2 - 3 h, open the solenoid valve at the liquid outlet of the extraction tank 1. The solvent enters the separation tank 2. Open the compressor 5. The extraction liquid continuously vaporizes and is condensed into a liquid state after compression and flows back to the solvent tank 3. Finally, obtain the oil from Suaeda salsa seeds from the oil drain port of the separation tank 2. Additionally, in the extraction stage, a gradient pressure increase (0.3 → 0.7 MPa) is adopted to improve the dissolution efficiency of the target components; in the separation stage, two-stage pressure reduction (0.7 → 0.3 → 0.1 MPa) is set to reduce the solvent entrainment loss; the condenser is cooled by circulating water (5 - 10 °C), and the liquefied solvent returns to the solvent tank; the set pressure of the system safety valve is 1.2 MPa to ensure safety.

[0031] The invention provides a linoleic acid soft capsule, which consists of a soft capsule shell and soft capsule contents. The raw materials for preparing the soft capsule shell, measured in parts by weight, include: 40-80 parts of carrageenan-Bletilla striata polysaccharide mixed gum, 20-50 parts of hydroxypropyl methylcellulose, 20-50 parts of octenyl succinate starch ester, 5-20 parts of a plasticizer, 0.01-0.1 parts of a sunscreen, and 150-250 parts of water. The soft capsule shell glue solution is prepared by mixing the carrageenan-Bletilla striata polysaccharide mixed gum with deionized water, heating the mixture to 80°C, then slowly adding the hydroxypropyl methylcellulose, octenyl succinate starch ester, the plasticizer and the sunscreen, stirring the mixture evenly, treating the mixture with a homogenizer, and removing bubbles by ultrasonication to obtain a viscous shell sol.

[0032] In the above glue solution preparation method, the ratio of carrageenan-Bletilla striata polysaccharide mixed glue is 10:1-5:1; the plasticizer is one or more combinations of glycerin, sorbitol, and xylitol; the sunscreen is one or more combinations of brilliant blue, lemon yellow, sunset yellow, and titanium dioxide; the stabilizer is any one of butylated hydroxyanisole, butylated hydroxytoluene, ascorbyl palmitate, and tea polyphenol palmitate; and the emulsifier is one or more of hydroxylated lecithin, xylitol anhydride monostearate, and propylene glycol fatty acid ester.

[0033] The contents of the soft capsule are calculated in parts by weight and include: 100-150 parts of conjugated linoleic acid, 0.01-1 part of vitamin E, 0.05-0.2 parts of a stabilizer, and 0.2-1 parts of an emulsifier. The contents are prepared by heating the conjugated linoleic acid, vitamin E, the stabilizer, and the emulsifier at 50-60° C. and stirring and mixing them, cooling to room temperature, and treating with a homogenizer to obtain an emulsion of the contents.

[0034] The preparation method of conjugated linoleic acid comprises the following steps: taking Suaeda salsa seed oil, placing it in glycerol, adding a catalyst NaOH, heating and stirring in an oil bath at 180° C. for 2 hours to complete the conjugation reaction, acidifying to obtain fatty acids, washing with distilled water to neutrality, and vacuum dehydrating to obtain conjugated linoleic acid;

[0035] Conjugated linoleic acid is prepared using Suaeda salsa seeds as a raw material. The linoleic acid soft capsules are prepared by using a capsule filling machine to form soft capsules using the shell sol and the content emulsion obtained in the above step according to the required amount ratio, and then drying to obtain the linoleic acid soft capsules. In the above steps, the mass ratio of the soft capsule shell to the soft capsule content is 1:1-1:3.

[0036] Example 1

[0037] A method for preparing linoleic acid soft capsules comprises the following steps:

[0038] (1) Preparation of the gum solution: By weight, take 50 parts of a carrageenan-bletilla striata polysaccharide mixed gum with a mass ratio of (5:1), add it to 100 parts of deionized water and stir. Heat to 80 °C, then add 20 parts of hydroxypropyl methylcellulose, 20 parts of octenyl succinic anhydride starch ester, 10 parts of glycerol, and 0.01 part of tartrazine. Keep stirring until the gum solution becomes a viscous liquid, then process it with a homogenizer and remove air bubbles by ultrasound to obtain a viscous outer shell sol.

[0039] (2) Preparation of the content: Open the extraction tank and load 60-mesh pre-treated crushed seepweed seeds. Seal the equipment, turn on the vacuum pump to put the whole system under vacuum, close the liquid outlet of the extraction tank, and inject the extraction solvent, solvent No. 4, into the extraction tank in the form of a subcritical fluid through a metering pump. During the extraction process, both the pressure and temperature are automatically reached and maintained at 50 °C by the controller according to the set value. After 3 hours of extraction time, open the liquid outlet of the extraction tank, and the solvent enters the separation tank. Turn on the compressor, the extraction liquid continuously vaporizes, is compressed and condensed into a liquid state, and then flows back to the solvent storage tank. Finally, seepweed seed oil is obtained from the separation tank. Take 50 g of seepweed seed oil and place it in 150 ml of glycerol. Add 10 g of the catalyst NaOH, heat and stir in an oil bath at 180 °C for 2 hours. After the conjugation reaction ends, acidify to obtain fatty acids, wash with distilled water until neutral, dehydrate under vacuum to obtain conjugated linoleic acid. Then, according to parts by weight, mix 100 parts of conjugated linoleic acid, 0.05 part of vitamin E, 0.05 part of ascorbyl palmitate, and 0.3 part of hydroxylated lecithin, heat and stir at 60 °C, cool to room temperature, and process with a homogenizer to obtain the content emulsion;

[0040] (3) Use a capsule filling machine to make soft capsules from the outer shell sol and the content emulsion according to a dosage ratio of 1:1, and dry to obtain conjugated linoleic acid soft capsules.

[0041] Example 2

[0042] A method for preparing conjugated linoleic acid soft capsules, comprising the following steps:

[0043] (1) Preparation of the gum solution: By weight, take 60 parts of a carrageenan-bletilla striata polysaccharide mixed gum with a mass ratio of (10:1), add it to 150 parts of deionized water and stir. Heat to 80 °C, then add 30 parts of hydroxypropyl methylcellulose, 30 parts of octenyl succinic anhydride starch ester, 20 parts of glycerol, 5 parts of sorbitol, and 0.01 part of sunset yellow. Keep stirring until the gum solution becomes a viscous liquid, then process it with a homogenizer and remove air bubbles by ultrasound to obtain a viscous outer shell sol.

[0044] (2) Content configuration: Open the extraction tank and load 60-mesh pre-treated crushed seepweed seeds. Seal the equipment. Turn on the vacuum pump to put the whole system in a vacuum state. Close the liquid outlet of the extraction tank. Inject the extraction solvent, No. 4 solvent, into the extraction tank in the form of a subcritical fluid through a metering pump. The pressure and temperature during the extraction process are automatically reached and maintained at 50 °C by the controller according to the set values. After the extraction time of 2 h is reached, open the liquid outlet of the extraction tank, and the solvent enters the separation tank. Turn on the compressor, and the extraction liquid is continuously vaporized and condensed into a liquid state after compression and then flows back into the solvent storage tank. Finally, seepweed seed oil is obtained from the separation tank. Take 50 g of seepweed seed oil and place it in 150 ml of glycerol. Add 10 g of the catalyst NaOH. After heating and stirring at 180 °C in an oil bath for 2 h for the conjugation reaction to end, obtain fatty acids after acidification, wash with distilled water until neutral, dehydrate under vacuum to obtain conjugated linoleic acid. Then, according to the weight parts, mix 100 parts of conjugated linoleic acid, 0.05 part of vitamin E, 0.05 part of butylated hydroxyanisole, and 0.3 part of propylene glycol fatty acid ester by heating and stirring at 60 °C, cool to room temperature, and process with a homogenizer to obtain the content emulsion;

[0045] (3) Prepare soft capsules from the outer shell sol and the content emulsion according to the dosage ratio of 1:2 through a capsule filling machine, and dry to obtain conjugated linoleic acid soft capsules.

[0046] Example 3

[0047] A method for preparing conjugated linoleic acid soft capsules, comprising the following steps:

[0048] (1) Preparation of the glue solution: By weight, take 50 parts of a carrageenan-bletilla striata polysaccharide mixed glue with a mass ratio of (8:1) and add it to 150 parts of deionized water and stir. Heat to 80 °C, then add 30 parts of hydroxypropyl methylcellulose, 30 parts of octenyl succinic anhydride starch ester, 20 parts of glycerol, 5 parts of xylitol, and 0.01 part of brilliant blue, and continuously stir. After the glue solution becomes a viscous liquid, process it with a homogenizer and remove air bubbles by ultrasound to obtain a viscous outer shell sol.

[0049] (2) Content configuration: Open the extraction tank and load 80-mesh pre-treated crushed seepweed seeds. Seal the equipment. Turn on the vacuum pump to put the whole system in a vacuum state. Close the liquid outlet of the extraction tank. Inject the extraction agent, the fourth solvent, into the extraction tank in the form of subcritical fluid through a metering pump. During the extraction process, both the pressure and temperature are automatically reached and maintained at 40 °C by the controller according to the set value. After reaching the extraction time of 2 hours, open the liquid outlet of the extraction tank, and the solvent enters the separation tank. Turn on the compressor, and the extraction liquid continuously vaporizes and is condensed into a liquid state after compression and then flows back to the solvent storage tank. Finally, seepweed seed oil is obtained from the separation tank. Take 50 g of seepweed seed oil and place it in 150 ml of glycerol. Add 10 g of the catalyst NaOH. After heating and stirring at 180 °C in an oil bath for 2 hours until the conjugation reaction ends, fatty acids are obtained through acidification, washed with distilled water until neutral, dehydrated under vacuum to obtain conjugated linoleic acid. Then, according to the weight parts, 100 parts of conjugated linoleic acid, 0.05 part of vitamin E, 0.05 part of tea polyphenol palmitate, and 0.3 part of propylene glycol fatty acid ester are heated and stirred at 60 °C and mixed. After cooling to room temperature, it is processed by a homogenizer to obtain the content emulsion;

[0050] (3) Make soft capsules from the outer shell sol and the content emulsion according to the dosage ratio of 2:3 through a capsule filling machine, and dry to obtain the conjugated linoleic acid soft capsules.

[0051] Determination of physicochemical property indexes

[0052] 1. Conjugated acid conversion rate

[0053] Experimental method: Refer to GB5009.168-2016 "National Food Safety Standard - Determination of Fatty Acids in Foods" to establish a gas chromatography method to determine the fatty acid methyl esters obtained after methylation and determine their fatty acid composition. The conjugated conversion rate calculation formula is: conjugated linoleic acid / (conjugated linoleic acid + linoleic acid) × 100%.

[0054] 2. Ash determination

[0055] Experimental method: Refer to GB5009.4-2016 "National Food Safety Standard - Determination of Ash in Foods".

[0056] 3. Acid value determination

[0057] Experimental method: Refer to GB5009.229-2016 "National Food Safety Standard - Determination of Acid Value". Use a Metrohm 848 automatic titrator to take the content for determination.

[0058] Peroxide value

[0059] Experimental method: Refer to GB5009.227-2016 "National Food Safety Standard - Determination of Peroxide Value in Foods".

[0060] Disintegration time limit

[0061] Experimental method: Refer to the disintegration time limit inspection method in the General Principles of the Fourth Part of the Chinese Pharmacopoeia (2015 Edition).

[0062] Table 1 Detection Results of Physicochemical Indexes of Suaeda glauca Seed Crude Oil

[0063]

[0064]

[0065] Table 2 Detection Results of Physicochemical Indexes of Conjugated Linoleic Acid Soft Capsules

[0066] Case Conjugate acid conversion rate Ash content Acid value Peroxide value Disintegration time limit Example 1 ≥85％ ≤3％ 3.0mg / g 0.25g / 100g ≤60min Example 2 ≥85％ ≤3％ 2.5mg / g 0.20g / 100g ≤60min Example 3 ≥85％ ≤3％ 3.0mg / g 0.24g / 100g ≤60min

[0067] Experimental results:

[0068] It can be seen from the data of the examples in Table 2 that the conjugated linoleic acid soft capsule products prepared by the present invention have good properties, with good data for each item and stable process. The prepared conjugated linoleic acid soft capsules have the effects of softening blood vessels, preventing cardiovascular and cerebrovascular diseases, and improving blood circulation, which proves the feasibility of the process of making soft capsules with conjugated linoleic acid from Suaeda glauca as the main raw material. The method is simple and efficient, and is more suitable for industrial production.

[0069] However, as mentioned above, only the specific embodiments of the present invention are described herein, and the scope of implementation of the present invention cannot be limited thereby. Therefore, the replacement of equivalent components or the equivalent changes and modifications made according to the scope of protection of the present invention shall still fall within the scope covered by the claims of the present invention.

Claims

1. A soft capsule of linoleic acid, characterized in that, The conjugated linoleic acid soft capsule is prepared from a soft capsule shell and soft capsule contents; the raw materials for preparing the soft capsule shell, by weight, include: 40-80 parts of carrageenan-bletilla striata polysaccharide mixed gum, 20-50 parts of hydroxypropyl methyl cellulose, 20-50 parts of octenyl succinic anhydride starch ester, 5-20 parts of plasticizer, 0.01-0.1 part of light shielding agent, and 150-250 parts of water; the contents, by weight, include: 100-150 parts of conjugated linoleic acid, 0.01-1 part of vitamin E, 0.05-0.2 part of stabilizer, and 0.2-1 part of emulsifier; the conjugated linoleic acid is prepared from seepweed seeds as raw materials.

2. The soft capsule of linoleic acid according to claim 1, wherein, The preparation method of the conjugated linoleic acid is as follows: 2.1 Extract seepweed seed oil: Open the extraction tank and load the pre-treated crushed seepweed seeds. Seal the equipment, turn on the vacuum pump to make the whole system in a vacuum state, close the liquid outlet valve of the extraction tank, inject the extractant into the extraction tank in the form of subcritical fluid through a metering pump. The pressure and temperature during the extraction process are automatically reached and maintained by the control system according to the set values. After reaching the extraction time, open the liquid outlet valve of the extraction tank, and the solvent enters the separation tank. Turn on the compressor, the extraction liquid is continuously vaporized, compressed and condensed into a liquid state, and flows back to the solvent storage tank. Finally, seepweed seed oil is obtained from the separation tank; 2.2 Take the seepweed seed oil and place it in glycerol, add the catalyst NaOH, and heat and stir at 180 °C in an oil bath until the conjugation reaction ends to obtain a conjugated linoleate solution; 2.3 Acidify the conjugated linoleate solution to obtain fatty acids, wash with distilled water until neutral, and dehydrate under vacuum to obtain conjugated linoleic acid.

3. The soft capsule of linoleic acid according to claim 2, wherein, In step 2.1, the mesh number of the crushed seepweed seeds is 40-80 mesh; the extractant is solvent No. 4; the temperature during the extraction process is 40-60 °C; the extraction time is 2-3 h.

4. The soft capsule of linoleic acid according to claim 1, wherein The mass ratio of the soft capsule shell to the soft capsule contents is 1:1-1:

3.

5. The soft capsule of linoleic acid according to claim 1, characterized in that The ratio of the carrageenan-bletilla striata polysaccharide mixed gum is 10:1-5:

1.

6. The soft capsule of linoleic acid according to claim 1, wherein The plasticizer is one or a combination of glycerol, sorbitol, and xylitol.

7. The soft capsule of linoleic acid according to claim 1, wherein The light shielding agent is one or a combination of brilliant blue, lemon yellow, sunset yellow, and titanium dioxide.

8. The soft capsule of linoleic acid according to claim 1, wherein The stabilizer is any one of butylated hydroxyanisole, dibutyl hydroxytoluene, ascorbyl palmitate, and tea polyphenol palmitate.

9. The soft capsule of linoleic acid according to claim 1, wherein The emulsifier is one or more of hydroxylated lecithin, sorbitan monostearate, and propylene glycol fatty acid ester.

10. A preparation method of a conjugated linoleic acid soft capsule, using the raw material ratio of the conjugated linoleic acid soft capsule as described in any one of claims 4-9, characterized by including the following steps: 10.1 Prepare the glue solution: Heat and mix the carrageenan-bletilla striata polysaccharide mixed gum and water at 80 °C, then slowly add hydroxypropyl methyl cellulose, octenyl succinic anhydride starch ester, plasticizer, and light shielding agent, stir evenly, treat with a homogenizer, and remove air bubbles by ultrasonic treatment to obtain a viscous shell sol; 10.2 Prepare the contents: According to the weight parts, heat and stir and mix conjugated linoleic acid, vitamin E, stabilizer, and emulsifier at 50-60 °C, then cool to room temperature, and treat with a homogenizer to obtain a contents emulsion; 10.3 The soft capsule of linoleic acid is prepared by filling the outer shell sol and the content emulsion into soft capsules through a capsule filling mechanism according to the dosage ratio and then drying.

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