Preparation method of traditional Chinese medicine ointment for treating joint and cervical spondylosis

Abstract

The invention discloses a preparation method of a traditional Chinese medicine ointment for treating joint and cervical spondylosis, and relates to the technical field of traditional Chinese medicine unguts.According to the preparation method of the traditional Chinese medicine ointment for treating joint and cervical spondylosis, the ointment is applied to the skin of the part needing to be treated, and effective components of the contained medicine are absorbed by the skin and act on subcutaneous skin, so that the effect of treating joint and cervical spondylosis is achieved. Then, the medicine enters lymphatic organs and blood capillaries to enter arteries and veins, and all related visceral organs directly play a treatment role; a plurality of surfactants contained in the plaster can promote passive absorption and increase the absorption effect of epidermis on the medicine; a body meridian system is networked with the whole body to communicate the exterior, interior, exterior and interior, twelve meridians and collaterals, the interior belongs to viscera, outer collaterals and limbs, the exterior is externally connected with twelve skin parts, and after being absorbed by the skin, the medicine is internally connected with the viscera and externally connected with limbs along the meridians and collaterals, so that a treatment effect is achieved; the medicine in the plaster directly reaches the lesion, and the local medicine concentration of the lesion is increased, so that the treatment effect is improved.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine ointments, and in particular to a preparation method of traditional Chinese medicine ointment for treating joint and cervical spondylosis. Background Art

[0002] The existing preparation methods of traditional Chinese medicine ointments for treating joint and cervical spondylosis still have the following drawbacks in actual use:

[0003] Pain in the waist, knees, cervical spine, and joints is one of the most common clinical diseases. It makes patients suffer from unbearable pain and unbearable pain. Currently, both Chinese and Western medicine have many drugs and methods that have certain effects on the treatment of pain in the waist, knees, cervical spine, and joints. Traditional therapies include:

[0004] (1) Chemotherapy: Although existing nonsteroidal anti-inflammatory drugs (NSAIDs) and opioids can provide short-term analgesia, long-term use can easily cause gastrointestinal damage, liver and kidney toxicity, and addiction (such as ibuprofen and diclofenac sodium);

[0005] (2) Rehabilitation physical therapy: methods such as hot compress and electrotherapy require professional equipment, have long treatment cycles and poor portability, and are difficult to meet patients' daily continuous analgesia needs;

[0006] (3) Chinese herbal medicine slices are taken internally and can be irritating to the digestive system. They also take a long time to work and often require several days of use.

[0007] (4) Traditional Chinese medicine plasters: low transdermal absorption efficiency, active ingredients (such as ligustrazine, paeoniflorin) have large molecular weights and are difficult to penetrate the stratum corneum; irritating ingredients remain in the plaster, such as some formulas containing raw Chuanwu and capsaicin, which can easily cause skin redness, swelling, and itching (clinical reporting rate is about 15%). Summary of the Invention

[0008] The purpose of the present invention is to provide a method for preparing a traditional Chinese medicine ointment for treating joint and cervical spondylosis, so as to solve the above-mentioned problems.

[0009] In order to achieve the above object, the present invention provides the following technical solution: a method for preparing a traditional Chinese medicine ointment for treating joint and cervical spondylosis, comprising the following steps:

[0010] (1) Weigh the following raw materials by weight: 10-12 parts of raw Chuanwu, 10-12 parts of raw Caowu, 5-7 parts of scorpion, 5-7 parts of centipede, 8-10 parts of frankincense, 8-10 parts of myrrh, 8-10 parts of safflower, 5-7 parts of dragon's blood, 8-10 parts of dactylorhizon, 12-15 parts of scutellaria baicalensis, 3-5 parts of borneol, and 25-40 parts of sesame oil;

[0011] (2) Grinding the raw Chuanwu, raw Caowu, scorpion, centipede, frankincense, myrrh, safflower, dragon's blood, rhizoma dioscoreae, and radix scutellariae into granules respectively;

[0012] (3) Separate the active ingredients of each traditional Chinese medicine by extraction method;

[0013] (4) Mix the extracted active ingredients with borneol, natural beeswax, and sesame oil, and make a plaster matrix after stirring evenly.

[0014] Further, the optimal weight ratio of the raw materials is: 10 parts of raw Radix Aconiti Kusnezoffii, 10 parts of raw Radix Aconiti, 5 parts of Scorpio, 5 parts of Scolopendra, 8 parts of Olibanum, 8 parts of Myrrha, 8 parts of Flos Carthami, 5 parts of Sanguis Draxonis, 8 parts of Dioscorea Nipponica Makino, 12 parts of Herba Speranskiae Tuberculatae, 3 parts of borneol, and 35 parts of sesame oil.

[0015] Further, the particle size of the particles after grinding in the step (2) is 80 - 120 mesh.

[0016] Further, the extraction method in the step (3) is supercritical CO2 extraction or ethanol reflux extraction.

[0017] Further, the plaster matrix further includes a medical non-woven fabric layer and a non-stick release paper.

[0018] Further, its transdermal absorption efficiency ≥ 75%, and the incidence of skin allergic reactions < 5%.

[0019] Compared with the prior art, the preparation method of a traditional Chinese medicine plaster for treating joints and cervical spondylosis provided by the present invention has the following beneficial effects:

[0020] The preparation method of the traditional Chinese medicine plaster for treating joints and cervical spondylosis involves applying the plaster on the skin of the affected area. The active ingredients of the drugs contained therein are absorbed through the skin, act on the subcutaneous layer, then enter the lymphatic organs, capillaries and into the arteries and veins, directly treating the relevant organs. Some surfactants contained in the plaster can promote passive absorption and increase the absorption of drugs by the epidermis. The meridian system of our body networks the whole body, communicating the interior and exterior, the upper and lower. The twelve meridians: internally belong to the zang-fu organs, externally connect to the limbs and joints, and externally link to the twelve skin regions. After the drugs are absorbed through the skin, they follow the meridians, internally connecting to the zang-fu organs and externally connecting to the limbs, thus playing a therapeutic role. The drugs in the plaster patch reach the affected area directly, increasing the local drug concentration and improving the treatment effect. The plaster patch is applied locally, and the drug concentration in the tissue is significantly higher than that in the blood, so it plays a full role, and the local curative effect is significantly better than the internal treatment method. Moreover, the drug effect is exerted quickly, which is very suitable for those who are inconvenient to take medicine or reluctant to take medicine. Because oral medications need to be absorbed through the gastrointestinal tract, degraded by gastric acid, metabolized by the liver, enter the heart, and circulate throughout the body with the blood. When the drug properties reach the affected area, due to its distance from the zang-fu organs and insufficient circulating blood volume, the curative effect is very small. While the plaster is directly applied to the affected area and continuously exerts its drug effect through transdermal absorption, so the curative effect is remarkable. In addition, it applies drugs to the affected part, adjacent parts and acupoints, forming a high drug concentration locally while the blood concentration is very low, thus avoiding the toxic and side effects of the drug on the liver and other organs. Therefore, it is very safe and reliable. When in use, just tear open the package and apply it to the affected part to achieve the purpose of treating diseases. It is convenient to use, has a rapid curative effect and a low price. Detailed implementation mode

[0021] In order to enable those skilled in the art to better understand the technical solution of the present invention, the present invention will be further introduced in detail below.

[0022] A preparation method of a traditional Chinese medicine plaster for treating joints and cervical spondylosis includes the following steps:

[0023] (1) Weigh the raw materials according to the weight ratio: 10 - 12 parts of raw Radix Aconiti Kusnezoffii, 10 - 12 parts of raw Radix Aconiti Carmichaeli, 5 - 7 parts of Scorpio, 5 - 7 parts of Scolopendra, 8 - 10 parts of Olibanum, 8 - 10 parts of Myrrha, 8 - 10 parts of Flos Carthami, 5 - 7 parts of Sanguis Draxonis, 8 - 10 parts of Rhizoma Dioscoreae Nipponicae, 12 - 15 parts of Herba Speranskiae Tuberculatae, 3 - 5 parts of Borneolum Syntheticum, 25 - 40 parts of sesame oil;

[0024] (2) Grind raw Radix Aconiti Kusnezoffii, raw Radix Aconiti Carmichaeli, Scorpio, Scolopendra, Olibanum, Myrrha, Flos Carthami, Sanguis Draxonis, Rhizoma Dioscoreae Nipponicae, and Herba Speranskiae Tuberculatae into granular form respectively;

[0025] (3) Separate the active ingredients of each traditional Chinese medicine through an extraction method;

[0026] (4) Mix the extracted active ingredients with Borneolum Syntheticum, natural beeswax, and sesame oil, and stir evenly to make a paste matrix for the plaster patch.

[0027] The optimal weight ratio of the raw materials is as follows: 10 parts of Aconitum carmichaelii Debx., 10 parts of Aconitum kusnezoffii Reichb., 5 parts of Scorpio, 5 parts of Scolopendra, 8 parts of Olibanum, 8 parts of Myrrha, 8 parts of Flos Carthami, 5 parts of Sanguis Draxonis, 8 parts of Dioscorea nipponica Makino, 12 parts of Herba Speranskiae tuberculatae, 3 parts of Borneol, and 35 parts of sesame oil.

[0028] Grind different traditional Chinese medicines into granules respectively by the grinding method, extract the active ingredients of the drugs through technology, and they are small molecules, then make them into plasters; directly apply them to the affected area, once a day, 10 - 12 hours each time.

[0029] Aconitum carmichaelii Debx.: It is hot in nature, pungent and bitter in taste; functions and indications: dispelling wind and dampness, warming channels and relieving pain; it belongs to the drugs for dispelling wind and dampness and cold under the classification of drugs for dispelling wind and dampness.

[0030] Aconitum kusnezoffii Reichb.: It is hot in nature, pungent and bitter in taste; functions and indications: dispelling wind, dampness, cold and relieving pain; it belongs to the drugs for dispelling wind and dampness and cold under the classification of drugs for dispelling wind and dampness.

[0031] Scorpio: It is neutral in nature, pungent in taste; functions and indications: calming endogenous wind and stopping convulsions, attacking toxins and resolving masses, dredging channels and relieving pain.

[0032] Scolopendra: It is warm in nature, pungent in taste; functions and indications: calming endogenous wind and stopping convulsions, attacking toxins and resolving masses, dredging channels and relieving pain.

[0033] Olibanum: It is pungent, bitter and slightly warm; functions and indications: promoting blood circulation and qi movement, dredging channels and relieving pain, dissipating swelling and promoting granulation, pain in the heart and abdomen, rheumatic arthralgia, amenorrhea and dysmenorrhea, traumatic stasis pain, carbuncle and swelling toxin, intestinal abscess, non - healing of sores.

[0034] Myrrha: It is bitter and flat; functions and indications: promoting blood circulation to relieve pain, dissipating swelling and promoting granulation, stasis pain in the chest and abdomen, dysmenorrhea, amenorrhea, mass in the abdomen, traumatic injury, carbuncle and swelling sores, intestinal abscess, red and swollen eyes with pain.

[0035] Flos Carthami: It is warm in nature, pungent in taste; functions and indications: promoting blood circulation to dredge channels, dispersing stasis and relieving pain.

[0036] Sanguis Draxonis: It is sweet, salty and flat; functions and indications: removing stasis and relieving pain, stopping bleeding and promoting granulation; used for fractures and contusions, internal injury stasis pain; external bleeding that does not stop.

[0037] Dioscorea nipponica Makino: It is warm in nature, sweet and bitter in taste; functions and indications: promoting blood circulation and relaxing tendons, dispelling wind and relieving pain, relieving cough, asthma and expectoration.

[0038] Herba Speranskiae tuberculatae: It is warm in nature, pungent in taste; functions and indications: dispelling wind and dampness, relaxing tendons and activating blood circulation, dispersing stasis and reducing swelling, detoxifying and relieving pain.

[0039] Borneol: It is pungent, bitter and slightly cold; functions and indications: resuscitating the patient from unconsciousness, clearing heat and relieving pain, used for coma due to febrile diseases, convulsions, syncope due to phlegm - stroke, sudden syncope due to qi stagnation, syncope due to pestilence, red eyes, mouth sores, sore throat, suppurative otitis media.

[0040] Sesame oil: It has a faint smell or the aroma of cooked sesame seeds, and a light taste; Functions and indications: lubricant and excipient, can moisten the intestines and lungs when taken orally, and is used as the matrix of ointment and plaster externally.

[0041] In step (2), the particle size of the ground particles is 80 - 120 mesh.

[0042] The extraction method in step (3) is supercritical CO2 extraction or ethanol reflux extraction.

[0043] If the supercritical CO2 extraction method is adopted, put the ground traditional Chinese medicine particles into the extraction kettle; set the extraction pressure to 20 - 30 MPa, the extraction temperature to 35 - 45 °C, and the CO2 flow rate to 10 - 20 L / h; under this condition, supercritical CO2 can effectively dissolve the active ingredients in the traditional Chinese medicine, and the extraction time is controlled within 2 - 4 hours to fully dissolve the active ingredients in the CO2 fluid; then, by adjusting the temperature and pressure, separate the CO2 fluid from the active ingredients, and collect the extract rich in the active ingredients of traditional Chinese medicine.

[0044] When choosing ethanol reflux extraction, put the traditional Chinese medicine particles into a round-bottom flask, add 5 - 10 times the amount of 95% ethanol; connect the reflux condenser device, heat until the ethanol boils, and maintain the reflux state for 3 - 5 hours; during this process, the active ingredients in the traditional Chinese medicine dissolve in the ethanol; after the reflux ends, cool the extract, filter to remove the medicinal residues, and obtain the ethanol extract; then, by means of vacuum distillation, evaporate and recover the ethanol in the ethanol extract to obtain the concentrated extract of the active ingredients of traditional Chinese medicine.

[0045] The plaster matrix also includes a medical non-woven fabric layer and a non-stick release paper.

[0046] Mix the extracted active ingredients of traditional Chinese medicine with borneol, natural beeswax, and sesame oil; first grind the borneol into fine powder, and then add it together with the active ingredients of traditional Chinese medicine and natural beeswax into the sesame oil; use a stirrer to stir at a speed of 200 - 300 r / min for 30 - 60 minutes to fully mix and homogenize each component to form the plaster matrix.

[0047] The plaster matrix also includes a medical non-woven fabric layer and a non-stick release paper; evenly apply the prepared paste on the medical non-woven fabric layer, control the coating thickness within 0.5 - 1 mm, then cover with the non-stick release paper, and cut it into appropriate sizes to obtain the finished traditional Chinese medicine plaster.

[0048] Its transdermal absorption efficiency ≥ 75%, and the incidence of skin allergic reactions < 5%.

[0049] Only some exemplary embodiments of the present invention have been described by way of illustration. Without doubt, for those of ordinary skill in the art, various different ways can be used to modify the described embodiments without departing from the spirit and scope of the present invention. Therefore, the above description is illustrative in nature and should not be construed as a limitation on the scope of protection of the claims of the present invention.

Claims

1. A preparation method of a traditional Chinese medicine paste for treating joint and cervical spondylosis, characterized in that, It includes the following steps: (1) Weigh the raw materials according to the weight ratio in parts by weight: 10-12 parts of Aconitum carmichaelii Debx., 10-12 parts of Aconitum kusnezoffii Reichb., 5-7 parts of Scorpio, 5-7 parts of Scolopendra, 8-10 parts of Olibanum, 8-10 parts of Myrrha, 8-10 parts of Flos Carthami, 5-7 parts of Sanguis Draxonis, 8-10 parts of Dioscorea nipponica Makino, 12-15 parts of Herba Speranskiae tuberculatae, 3-5 parts of Borneol, 25-40 parts of sesame oil; (2) Grind the Aconitum carmichaelii Debx., Aconitum kusnezoffii Reichb., Scorpio, Scolopendra, Olibanum, Myrrha, Flos Carthami, Sanguis Draxonis, Dioscorea nipponica Makino, and Herba Speranskiae tuberculatae into granular forms respectively; (3) Separate the effective components of each traditional Chinese medicine by an extraction method; (4) Mix the extracted effective components with Borneol, natural beeswax, and sesame oil, and make a paste matrix after stirring evenly.

2. The preparation method of a traditional Chinese medicine paste for treating joint and cervical spondylosis according to claim 1, characterized in that, The optimal weight ratio of the raw materials is: 10 parts of Aconitum carmichaelii Debx., 10 parts of Aconitum kusnezoffii Reichb., 5 parts of Scorpio, 5 parts of Scolopendra, 8 parts of Olibanum, 8 parts of Myrrha, 8 parts of Flos Carthami, 5 parts of Sanguis Draxonis, 8 parts of Dioscorea nipponica Makino, 12 parts of Herba Speranskiae tuberculatae, 3 parts of Borneol, and 35 parts of sesame oil.

3. The preparation method of a traditional Chinese medicine paste for treating joint and cervical spondylosis according to claim 1, characterized in that, In the step (2), the particle size of the ground particles is 80-120 mesh.

4. The preparation method of a traditional Chinese medicine paste for treating joint and cervical spondylosis according to claim 1, characterized in that, The extraction method in the step (3) is supercritical CO2 extraction or ethanol reflux extraction.

5. The preparation method of a traditional Chinese medicine plaster for treating joint and cervical spondylosis according to claim 1, characterized in that, The paste matrix further includes a medical non-woven fabric layer and a release paper.

6. The preparation method of a traditional Chinese medicine paste for treating joint and cervical spondylosis according to claim 5, characterized in that, Its transdermal absorption efficiency is ≥75%, and the incidence rate of skin allergic reactions is <5%.