Traditional Chinese medicine composition for treating osteoarthritis

Abstract

The invention discloses a traditional Chinese medicine composition for treating osteoarthritis, and belongs to the technical field of traditional Chinese medicines. In the traditional Chinese medicine composition, monarch drugs are radix angelicae pubescentis and processed semen strychni; ministerial drugs comprise radix aconiti preparata, tripterygium wilfordii, radix clematidis and rhizoma drynariae; the adjuvant drugs comprise kadsura pepper stem, liquidambar formosana hance, pawpaw, rhizoma dioscoreae nipponicae, frankincense, ground beetle, herba epimedii, teasel root, herba siegesbeckiae and lycopodium clavatum; and the conductant drug is coix seed. The whole formula is monarch, minister, assistant and guide, cooperates with each other, is rigorous in formula, has the effects of dispelling wind and eliminating dampness, warming channels and expelling cold, removing stasis and diminishing swelling, relaxing tendons and dredging collaterals, and tonifying kidney and strengthening liver, can remove arthralgia of knee and ankle joints and recover functions, can be used for treating osteoarthritis, and has a wide application prospect.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine composition for treating osteoarthritis. Background Art

[0002] Osteoarthritis (OA) is a chronic degenerative disease characterized by degeneration of joint cartilage. It is also one of the main causes of disability and loss of work ability worldwide. Its epidemiological characteristics show that the prevalence increases significantly with age. The prevalence in people over 60 years old exceeds 30%, and it can reach 40%-50% in people over 80 years old. The incidence rate in women, especially postmenopausal women, is significantly higher than that in men. Data from the Global Burden of Disease Study (GBD) show that there were approximately 1 billion OA patients worldwide in 2020, and this number is expected to increase to 1.37 billion by 2040. Risk factors include age, obesity, mechanical injury, genetic factors and metabolic syndrome (diabetes, hypertension, etc. cause systemic inflammation). The pathophysiological mechanisms involve cartilage degeneration, synovial inflammation, subchondral bone sclerosis and osteophyte formation, accompanied by neuropeptide-mediated chronic pain.

[0003] Currently, there is no cure for OA, and treatment aims to relieve symptoms and delay progression. Non-pharmacological interventions include weight management, low-intensity aerobic exercise, and strength training. Physical therapy uses heat therapy, cold compresses, transcutaneous electrical stimulation (TENS), or manual therapy. Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and celecoxib are first-line pharmacological treatments, but gastrointestinal and cardiovascular risks should be considered. Topical medications (diclofenac gel, capsaicin patch) can reduce systemic side effects. Intra-articular glucocorticoid injections are used to control acute inflammation, and sodium hyaluronate improves joint lubrication. Platelet-rich plasma (PRP) and new targeted drugs (such as the IL-1 inhibitor canakinumab) are still under investigation. Surgical treatment covers early arthroscopic cleaning and terminal artificial joint replacement and osteotomy. Emerging therapies such as stem cell therapy (mesenchymal stem cells promote cartilage regeneration), gene editing technology (CRISPR / Cas9 targeted repair of pathogenic genes) and 3D printed biomaterials have shown potential, but challenges still exist, including the lack of early diagnostic markers, limitations of symptomatic treatment, and the risk of long-term medication and surgical complications. Osteoarthritis is more common in middle-aged and elderly people. The older the patient, the greater the probability of illness and the longer the illness lasts. In terms of treatment, patients in this group often have other underlying diseases. In addition, due to the patients' advanced age and their own willingness, the overall surgical risk is high and there are fewer patients willing to undergo surgery. Hospitals mostly use conservative treatment methods. Therefore, it is particularly important to develop methods that can avoid surgery as much as possible while treating the pain of osteoarthritis. Summary of the Invention

[0004] In view of the above-mentioned prior art, the object of the present invention is to provide a traditional Chinese medicine composition for treating osteoarthritis.

[0005] Traditional Chinese medicine believes that this disease is a progressive disease and belongs to the category of Bi syndrome - Bone Bi. The main causes are factors such as accumulated damage due to advanced age, being affected by exogenous pathogenic factors of wind, cold, dampness, and heat, and trauma, which lead to weakness of qi and blood, disharmony of nutrient qi and defensive qi, deficiency of liver and kidney, and damage to the acquired foundation. The fundamental pathogenesis is qi and blood stasis, mutual obstruction of phlegm and stasis, loss of nourishment of tendons and vessels, emptiness of bone marrow, blockage of meridians, and failure to achieve harmony between non - obstruction and nourishment, thus resulting in Bi syndrome. Through extensive clinical research on a large number of cases, the inventor has summarized an external - use composition with remarkable curative effect, convenient use, and no obvious toxic and side effects, which can expel wind, disperse cold, remove dampness, tonify liver and kidney, strengthen tendons and bones, resolve phlegm and disperse stasis, replenish essence and marrow, strengthen healthy qi and eliminate pathogenic factors, and is used for the treatment of osteoarthritis.

[0006] To achieve the above object, the present invention adopts the following technical scheme:

[0007] In the first aspect of the present invention, there is provided a traditional Chinese medicine composition for treating osteoarthritis, and the traditional Chinese medicine composition comprises raw materials in the following parts by weight: 28 - 32 parts of Angelica pubescens, 1 - 5 parts of Strychnos nux - vomica preparata, 8 - 12 parts of Aconitum carmichaelii preparata, 8 - 12 parts of Tripterygium wilfordii, 18 - 22 parts of Clematis chinensis, 18 - 22 parts of Drynaria fortunei, 13 - 17 parts of Piper kadsura, 10 - 14 parts of Liquidambar formosana, 13 - 17 parts of Chaenomeles sinensis, 13 - 17 parts of Dioscorea nipponica, 8 - 12 parts of Olibanum, 8 - 12 parts of Eupolyphaga seu Steleophaga, 13 - 17 parts of Epimedium brevicornu, 10 - 14 parts of Dipsacus asperoides, 13 - 17 parts of Siegesbeckia orientalis, 13 - 17 parts of Lycopodium clavatum, and 16 - 20 parts of Coix lacryma - jobi.

[0008] The formula explanation of the present invention is as follows:

[0009] Angelica pubescens and Strychnos nux - vomica preparata together serve as the monarch drugs. Angelica pubescens, property of the medicine: pungent, bitter, warm. Efficacy: expel wind and dampness, dredge collaterals and relieve pain, induce sweating. Pungency can disperse cold, warmth can dredge meridians, bitterness can dry dampness, and it can also strengthen yin. It mainly enters the kidney meridian, can treat Bi syndrome of long duration with deficiency of healthy qi, soreness and weakness of waist and knees, and difficulty in flexion and extension of joints. It can be selected for rheumatism caused by exogenous pathogenic factors, whether new or long - standing, and is especially good at treating lower - body rheumatism. External washing with this medicine can also treat skin itching, so it can reduce the irritation of other drugs to the skin. Modern medical research shows that this medicine has anti - inflammatory, analgesic, and sedative effects, can inhibit platelet aggregation, and has an anti - aging effect. "The Supplementary Records of Famous Physicians" records that Angelica pubescens is mainly used to treat "all kinds of pathogenic wind, gout of all joints, regardless of new or old". Strychnos nux - vomica preparata, property of the medicine: bitter, warm, highly toxic. Efficacy: dredge collaterals and relieve pain, disperse stasis and reduce swelling. This medicine is good at promoting qi circulation and is an important medicine for treating pain in orthopedics and traumatology, especially excellent for pain caused by traumatic stasis. It is also good at searching for rheumatism in tendons and bones, opening meridians, penetrating joints, with strong pain - relieving power, and is a commonly used medicine for treating stubborn rheumatism, contracture pain, numbness, and paralysis. Zhang Xichun said that its "power of opening meridians and penetrating joints is far superior to other drugs", and it can also disperse stasis and reduce swelling, and has a good effect of promoting the absorption of joint swelling and effusion. Modern medical research shows that this medicine has a good analgesic effect.

[0010] Prepared Aconitum carmichaelii Debx., Tripterygium wilfordii Hook. f., Clematis chinensis Osbeck and Drynaria fortunei (Kunze) J. Sm. together serve as ministerial drugs. Prepared Aconitum carmichaelii Debx.: Its medicinal properties are pungent, bitter, and hot, and it pertains to the heart, liver, spleen, and kidney meridians. This herb is pungent, hot, bitter, and dry, being good at expelling pathogenic cold and dampness, and also capable of warming the meridians to relieve pain. It has been a fine herb for treating stubborn cold-damp arthralgia by past generations of physicians. "For all stubborn cold syndromes, using this herb will achieve effects without fail", and it is especially suitable for arthralgia with preponderance of pathogenic cold. In addition, for traumatic injury and fracture with stasis swelling, whether the pain is new or long-standing, it has good effects in healing injuries and mending fractures, and dissipating stasis to relieve pain, and it was also a commonly used anesthetic by ancient physicians. Due to its strong power in warming the meridians and dispelling cold, making up for the insufficiency of the monarch drug in dispelling cold, it is thus selected as the first ministerial drug. Modern medical research has confirmed that this herb has obvious anti-inflammatory, analgesic, and immunosuppressive effects. Tripterygium wilfordii Hook. f.: Its medicinal properties are bitter, pungent, and cold, and it pertains to the liver and kidney meridians. Its effects are expelling wind and dampness, activating blood circulation to dredge collaterals, reducing swelling and relieving pain, killing parasites and detoxifying. Ancient medical records state: "Treating low back pain, migratory arthralgia, stroke, knee joint pain with wind contracture qi syndrome...". This herb has strong effects in expelling wind-dampness, clearing damp-heat, and activating blood circulation to dredge collaterals, and is a key herb for treating stubborn wind-damp-heat arthralgia, especially suitable for those with red, swollen, hot, and painful joints, difficult-to-eliminate swelling, morning stiffness, limited joint function, and even joint deformity. Modern medical research shows that this herb has strong anti-inflammatory, analgesic, anti-tumor, anti-fibrotic and other effects. Clematis chinensis Osbeck: Its medicinal properties are pungent, salty, and warm, and it pertains to the bladder meridian. Its effects are expelling wind-dampness, dredging collaterals, relieving pain, eliminating bone stuck, and eliminating phlegm and fluid-retention. This herb is pungent, dispersing, warm and dredging, salty and capable of softening hardness and dissipating nodules, being fierce and good at moving. It can both expel wind-dampness, dredge collaterals to relieve pain, and dissipate phlegm and fluid-retention, and is a key herb for treating wind-damp arthralgia. It can be applied to all wind-damp arthralgia, limb numbness, muscle spasms, and difficulty in flexion and extension, especially those with preponderance of wind pathogen. Moreover, it has quite good curative effects on post-traumatic residual pain. Modern medical research shows that this herb has analgesic, anti-inflammatory, anti-diuretic, blood pressure-lowering, liver and gallbladder-protecting, smooth muscle-relaxing and other effects. "Compendium of Materia Medica" records that "for pain due to wind-damp phlegm and fluid-retention, those with strong qi will have quick effects after taking it". Drynaria fortunei (Kunze) J. Sm.: Its medicinal properties are bitter and warm, and it pertains to the liver and kidney meridians. Its effects are promoting blood circulation to heal injuries, relieving pain, and tonifying the kidney and strengthening bones. "Chinese Herbal Medicine" states that "(it is) bitter, pungent, highly toxic, expelling wind and dampness, activating blood circulation to dredge collaterals, reducing swelling and relieving pain". This herb is bitter, dry, warm, and dredging, capable of promoting blood circulation to dredge the channels, dissipating stasis and reducing swelling, healing injuries and relieving pain, and mending sinews and bones. It got its name for being good at tonifying bone fragments, and is a key herb for orthopedics. Moreover, it can warm and tonify the kidney yang, strengthen muscles and bones, and is especially suitable for symptoms such as flaccidity of muscles and bones, osteoporosis, degeneration, and meniscus injury in the elderly, being able to achieve the curative effects of treating both the symptoms and the root causes. Modern medical research has confirmed that this herb can promote the absorption of calcium by bones, increase the concentrations of blood calcium and phosphorus, be beneficial to fracture healing, improve chondrocytes, delay the degenerative changes of bone cells, and has obvious sedative and analgesic effects.

[0011] Piper kadsura, Liquidambar formosana Hance, Chaenomeles sinensis (Thouin) Koehne, Dioscorea nipponica Makino, Olibanum, Eupolyphaga seu Steleophaga, Epimedium brevicornu Maxim., Dipsacus asperoides C. Y. Cheng et T. M. Ai, Siegesbeckia orientalis L., Lycopodium clavatum L. are used as assistant drugs together. Piper kadsura has the effects of dispelling wind-dampness, dredging meridians and stopping arthralgia. It can be applied to all types of wind-cold-damp arthralgia, limb pain, muscle spasm, and limited flexion and extension. Liquidambar formosana Hance has the effects of expelling wind and activating collaterals, promoting diuresis and dredging channels. It has good curative effects on rheumatic arthralgia, numbness and spasm, hemiplegia due to stroke, traumatic injury, and joint effusion. Moreover, it can expel wind and relieve itching, and reduce the redness, swelling, itching and other symptoms caused by the skin irritation of other drugs. Chaenomeles sinensis (Thouin) Koehne has the effects of relaxing tendons and activating collaterals, eliminating dampness and regulating the middle-jiao. This herb tastes sour and enters the liver meridian. It is good at relaxing tendons and activating collaterals, and can also eliminate dampness and relieve arthralgia. It is especially the key herb for damp arthralgia with muscle spasm. Eliminating dampness can absorb the dampness retained in the joints and prevent recurrence. Dioscorea nipponica Makino has the effects of expelling wind and dampness, relaxing tendons and dredging collaterals, promoting blood circulation to relieve pain, and relieving cough and asthma. This herb enters the liver and kidney meridians, can dispel wind-dampness and promote blood circulation and dredge collaterals. It is often used for rheumatic arthralgia, joint swelling, low back and leg pain, limb numbness, and traumatic knee and ankle joint bone and tendon injuries, blood stasis obstruction pain and other symptoms with good curative effects. "Phlegm often causes problems in long-term diseases", this disease is closely related to phlegm-fluid. This herb also has the effect of resolving phlegm, so it is selected. Olibanum has the effects of promoting blood circulation to relieve pain, detumescence and promoting granulation. This herb is pungent, fragrant, running, bitter, purging, warm. It can not only promote blood circulation and remove blood stasis, relieve pain, but also promote blood circulation to eliminate carbuncle, remove necrosis and promote granulation. It is an important drug for orthopedics. Therefore, it is especially suitable for the elderly with poor repair function. This herb enters both the blood aspect and the qi aspect, can promote qi stagnation in the blood, promote qi and blood of the zang-fu organs, penetrate the meridians, and is good at relieving pain. Eupolyphaga seu Steleophaga has the effects of breaking blood stasis, removing stasis, and reconnecting tendons and bones. This herb mainly belongs to the liver meridian, enters the blood aspect, is good at running, has strong blood-activating power, is good at breaking blood stasis, relieving swelling and pain, and reconnecting tendons and bones. It has particularly good effects on fractures and tendon injuries in the later stage, weak tendons and bones, and swelling and pain due to stasis. Epimedium brevicornu Maxim. has the properties of pungent, sweet, warm. It belongs to the liver and kidney meridians. Its effects are tonifying the kidney and strengthening yang, strengthening tendons and bones, and dispelling wind-dampness. This herb is pungent, sweet, warm and dry. It can tonify the kidney yang. "Huangdi Neijing" says: "At the age of seven or eight in men, the heavenly essence dries up, sperm is scanty, the kidney function declines, the body is extremely weak, and the teeth and hair fall out." Therefore, this herb has the effect of strengthening the healthy qi and consolidating the root, and can also dispel wind-dampness, disperse wind-cold, enter the liver and kidney, strengthen tendons and bones. It is especially suitable for rheumatic arthralgia patients with long-term illness, old age, kidney failure, weak tendons and bones, or those with yang deficiency in the constitution and weak tendons and bones. Dipsacus asperoides C. Y. Cheng et T. M. Ai has the properties of bitter, pungent, slightly warm. It belongs to the liver and kidney meridians. Its effects are tonifying the liver and kidney, strengthening tendons and bones, and reconnecting fractures. This herb can tonify the liver and kidney, strengthen tendons and bones, treat liver and kidney deficiency, weak tendons and bones, and those with stubborn rheumatic arthralgia can achieve the effect of treating both the symptoms and the root causes. In addition, this herb is pungent, dispersing, warm and dredging. It can promote blood circulation to remove blood stasis, reconnect tendons and heal injuries. It is a commonly used drug in orthopedics and a good medicine for treating traumatic injuries, blood stasis swelling and pain, tendon and bone fractures. Siegesbeckia orientalis L. has the properties of pungent, bitter, cold. Its effects are dispelling wind-dampness, promoting joint movement, and detoxifying. This herb is pungent, dispersing, bitter and dry. It can dispel wind-dampness in the tendons and bones, dredge meridians, promote joint movement. Raw Siegesbeckia orientalis L. is cold in nature and is used to treat rheumatic heat arthralgia. It can also restrict the pungent, hot and dry nature of other drugs. After being processed with wine, it has the effect of tonifying the liver and kidney. It is often used for rheumatic arthralgia, weak tendons and bones, soreness and weakness of the waist and knees, limb paralysis, hemiplegia, etc. It can also clear heat and detoxify, remove damp-heat, and is effective for rubella, eczema, carbuncles and sores. Moreover, it has a good antihypertensive effect.Herba Lycopodii, efficacy: expelling wind and removing dampness, relaxing tendons and activating collaterals, treating wind-cold-damp arthralgia, joint soreness, limited flexion and extension, and traumatic injury. It can not only relax tendons and activate collaterals, reduce swelling and relieve pain, but also has an excellent effect on dissipating stasis obstruction.

[0012] Coix seed is the adjuvant drug. Coix seed, medicinal properties: sweet, light, cool, attributing to the spleen, stomach, and lung meridians. Efficacy: promoting diuresis and percolating dampness, strengthening the spleen and stopping diarrhea, eliminating impediment and discharging pus, detoxifying and resolving masses. This product is light and sweet, can not only promote diuresis and reduce swelling, but also strengthen the spleen and replenish the middle. The spleen is the foundation of acquired constitution and the source of qi and blood generation. Especially for the elderly, it can not only achieve the effect of treating both the principal and secondary aspects of the disease, but also reconcile the pungent, warm, and dry nature of various drugs, and can also percolate dampness and eliminate impediment, relax tendons and vessels, relieve spasm, clear heat and promote diuresis. It is a good medicine for treating damp-heat flaccidity syndrome, numbness of both feet, flaccidity and swelling pain. Coix seed can also detoxify and resolve masses, and can be used for diseases such as verrucae, cancer, and joint lesions.

[0013] Furthermore, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 30 parts of Angelica pubescens, 3 parts of prepared Strychnos nux-vomica, 10 parts of prepared Aconitum carmichaelii, 10 parts of Tripterygium wilfordii, 20 parts of Clematis chinensis, 20 parts of Drynaria fortunei, 15 parts of Piper kadsura, 12 parts of Liquidambar formosana, 15 parts of Chaenomeles sinensis, 15 parts of Dioscorea nipponica, 10 parts of Olibanum, 10 parts of Eupolyphaga seu Steleophaga, 15 parts of Epimedium brevicornu, 12 parts of Dipsacus asperoides, 15 parts of Siegesbeckia orientalis, 15 parts of Herba Lycopodii, and 18 parts of Coix seed.

[0014] In the second aspect of the present invention, there is provided the use of the described traditional Chinese medicine composition in the preparation of a drug for treating osteoarthritis.

[0015] In the third aspect of the present invention, there is provided a drug for treating osteoarthritis, and the drug uses the described traditional Chinese medicine composition as an active ingredient.

[0016] Furthermore, the drug may further comprise pharmaceutically acceptable excipients.

[0017] Furthermore, the dosage form of the drug is an aqueous solution, an ointment, or a powder.

[0018] Furthermore, when the drug is a decoction, the preparation method of the drug comprises the following steps:

[0019] Place the prepared Aconitum carmichaelii in 400 - 600 ml of boiling water, keep warm and soak for 0.5 - 2 hours, decoct for 0.5 - 2 hours to obtain the decoction of prepared Aconitum carmichaelii; separately soak the other drugs in 3000 - 4000 ml of warm water for 0.5 - 2 hours, transfer all of them, combine with the decoction of prepared Aconitum carmichaelii, bring to a boil over high heat, and then simmer over low heat for 20 - 80 minutes to obtain the drug for treating osteoarthritis.

[0020] The beneficial effects of the present invention:

[0021] 1. According to the compatibility method of "sovereign, minister, assistant, and guide", the present invention provides a traditional Chinese medicine composition for treating osteoarthritis. In the traditional Chinese medicine composition, Heracleum hemsleyanum Diels and Strychnos nux-vomica L. preparata are the sovereign drugs; Aconitum carmichaelii Debx. preparata, Tripterygium wilfordii Hook. f., Clematis chinensis Osbeck, and Drynaria fortunei (Kunze) J. Sm. are the minister drugs; Piper kadsura (Choisy) Ohwi, Saururus chinensis (Lour.) Baill., Chaenomeles sinensis (Thouin) Koehne, Dioscorea nipponica Makino, Olibanum, Eupolyphaga sinensis Walker, Epimedium brevicornu Maxim., Dipsacus asperoides C. Y. Cheng et T. M. Ai, Siegesbeckia orientalis L., and Lycopodium clavatum L. are the assistant drugs; Coix lacryma-jobi L. is the guide drug. The whole formula has a clear division of labor and cooperation among the sovereign, minister, assistant, and guide drugs, with a rigorous prescription, and together they achieve the effects of dispelling wind and dampness, warming the meridians and dispelling cold, removing stasis and reducing swelling, relaxing tendons and dredging meridians, and tonifying the kidney and strengthening the liver, so as to eliminate the arthralgia syndrome of the knee and ankle joints and restore their functions.

[0022] 2. Through repeated clinical research and verification, the present invention has summarized a complete usage plan for treating osteoarthritis based on the above traditional Chinese medicine composition. The traditional Chinese medicine composition provided by the present invention is used by hot compress, which is of great significance for the treatment of osteoarthritis. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 It is the diagnosis report of Patient 1 from Jinan People's Hospital.

[0024] Figure 2 It is the diagnosis report of Patient 1 when coming to our hospital.

[0025] Figure 3 It is the restoration effect diagram of Patient 1.

[0026] Figure 4 It is the initial diagnosis report of Patient 2 when coming to our hospital.

[0027] Figure 5 It is the follow-up diagnosis report of Patient 2 when coming to our hospital.

[0028] Figure 6 It is the restoration effect diagram of Patient 2.

[0029] Figure 7 It is the inspection report of Patient 3 from Laiwu Central Hospital of Shandong Yiyang Health Group.

[0030] Figure 8 It is the diagnosis report of Patient 3 when coming to our hospital.

[0031] Figure 9 It is the restoration effect diagram of Patient 3. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0032] It should be noted that the following detailed description is illustrative and is intended to provide further description of the present application. Unless otherwise specified, all technical and scientific terms used herein have the same meaning as commonly understood by those of ordinary skill in the technical field to which the present application belongs.

[0033] In order to enable those skilled in the art to better understand the technical solutions of the present application, the technical solutions of the present application will be described in detail below with reference to specific embodiments.

[0034] In the embodiments of the present invention, the test materials not specifically described are all conventional test materials in the art and can be obtained through commercial channels.

[0035] Example 1: Traditional Chinese medicine composition, its preparation method and usage

[0036] 1. Composition of traditional Chinese medicine composition

[0037] Angelica pubescens 30g, Strychnos nux-vomica preparata 3g, Aconitum carmichaelii preparata 10g, Tripterygium wilfordii Hook. f. 10g, Clematis chinensis Osbeck 20g, Drynaria fortunei (Kunze) J. Sm. 20g, Piper kadsura (Choisy) Ohwi 15g, Tetrapanax papyriferus (Hook.) K. Koch 12g, Chaenomeles sinensis (Thouin) Koehne 15g, Dioscorea nipponica Makino 15g, Boswellia carterii Birdw. 10g, Eupolyphaga sinensis Walker 10g, Epimedium brevicornu Maxim. 15g, Dipsacus asperoides C. Y. Cheng et T. M. Ai 12g, Siegesbeckia orientalis L. 15g, Lycopodium clavatum L. 15g, Coix lacryma-jobi L. var. ma-yuen (Roman.) Stapf 18g.

[0038] 2. Preparation method

[0039] Put Aconitum carmichaelii preparata into 500 ml of boiling water, soak it in a heat-preserving kettle for 1 hour, then transfer all of it to a container and decoct for 1 hour to obtain the decoction of Aconitum carmichaelii preparata. Separately, soak other drugs in 3500 ml of warm water for 1 hour, transfer all of them, combine with the decoction of Aconitum carmichaelii preparata, bring to a boil over high heat, and then simmer gently for 40 minutes to obtain the hot compress drug.

[0040] 3. Usage

[0041] Wait until the temperature of the hot compress drug drops to about 40°C, and adjust the temperature appropriately according to individual circumstances to prevent scalding. Put a towel into the hot compress drug, soak it and take it out, squeeze it until it doesn't drip, and wrap it around the affected area for hot compress for 0.5 h. In this process, 2 towels can be used alternately to keep the hot compress continuous. The hot compress is carried out 2 times a day, and one course of treatment is for two weeks.

[0042] Example 2: Traditional Chinese medicine composition, its preparation method and usage

[0043] 1. Composition of traditional Chinese medicine composition

[0044] Angelica pubescens 28g, Strychnos nux-vomica preparata 1g, Aconitum carmichaelii preparata 8g, Tripterygium wilfordii Hook. f. 8g, Clematis chinensis Osbeck 18g, Drynaria fortunei (Kunze) J. Sm. 18g, Piper kadsura (Choisy) Ohwi 13g, Tetrapanax papyriferus (Hook.) K. Koch 10g, Chaenomeles sinensis (Thouin) Koehne 13g, Dioscorea nipponica Makino 13g, Boswellia carterii Birdw. 8g, Eupolyphaga sinensis Walker 8g, Epimedium brevicornu Maxim. 13g, Dipsacus asperoides C. Y. Cheng et T. M. Ai 10g, Siegesbeckia orientalis L. 13g, Lycopodium clavatum L. 13g, Coix lacryma-jobi L. var. ma-yuen (Roman.) Stapf 16g.

[0045] 2. Preparation method

[0046] The preparation method of the drug is the same as that in Example 1.

[0047] 3. Usage

[0048] The usage of the drug is the same as that in Example 1.

[0049] Example 3: Traditional Chinese Medicine Composition, Its Preparation Method and Usage Method

[0050] 1. Composition of the traditional Chinese medicine composition:

[0051] Angelica pubescens 32g, Strychnos nux-vomica preparata 5g, Aconitum carmichaelii preparata 12g, Tripterygium wilfordii Hook. f. 12g, Clematis chinensis Osbeck 22g, Drynaria fortunei (Kunze) J. Sm. 22g, Piper kadsura (Choisy) Ohwi 17g, Liquidambar formosana Hance 14g, Chaenomeles sinensis (Thouin) Koehne 17g, Dioscorea nipponica Makino 17g, Olibanum 12g, Eupolyphaga seu Steleophaga 12g, Epimedium brevicornu Maxim. 17g, Dipsacus asperoides C. Y. Cheng et T. M. Ai 14g, Siegesbeckia orientalis L. 17g, Lycopodium clavatum L. 17g, Coix lacryma-jobi L. var. ma-yuen (Roman.) Stapf 20g.

[0052] 2. Preparation method

[0053] The preparation method of the medicine is the same as that in Example 1.

[0054] 3. Usage method

[0055] The usage method of the medicine is the same as that in Example 1.

[0056] Example 4: Verification of Clinical Experimental Results

[0057] 1. Patient 1

[0058] Lv Moumou 1, female, 63 years old. The first diagnosis was on July 10, 2023. Chief complaint: Pain in the right knee joint for several years, aggravated for half a year. Present medical history: The patient had pain in both knee joints after fatigue six or seven years ago, with the right side being more severe, and didn't pay attention. In the past half year, there was joint swelling and severe pain. Diagnosed by Jinan People's Hospital: 1. Bone marrow edema of the medial tibial plateau. 2. Medial meniscus injury and lateral meniscus degeneration. 3. A small amount of joint effusion in the knee joint. After a series of treatments such as fluid aspiration and intra-articular drug injection, the symptoms were relieved. On July 10, the pain worsened due to fatigue. The hospital recommended surgical treatment, but the patient refused and came for diagnosis. She had a history of hypertension and dyslipidemia for more than 10 years. The tongue was light red, the coating was thin and white, and the pulse was deep and tight. The inspection report is shown in Figures 1 - 2 .

[0059] Diagnosis: Western medicine diagnosis, right knee arthritis; Traditional Chinese medicine diagnosis, Bi syndrome - bone Bi.

[0060] Treatment: The traditional Chinese medicine formula in Example 1 was used for hot compress treatment for 4 courses, and the recovery was good. The patient could walk freely, as shown in Figure 3 .

[0061] 2. Patient 2

[0062] Duan XX, male, 67 years old. Chief complaint: Right knee pain for several years, aggravated for more than a month. Present illness history: The patient has felt right knee pain for several years, which is aggravated by fatigue. When it is severe, he cannot walk. After several months of diagnosis and treatment, the curative effect is poor, so he comes for treatment. Past history: He had rectal cancer surgery in 2021. The tongue is dull red, the coating is thin and white, and the pulse is deep and unsmooth. CT result: Osteophyte changes are seen at the edges of the bones forming the right knee joint, the intercondylar eminence becomes pointed, the medial joint space is relatively narrowed, and there is more fluid density in the suprapatellar bursa and joint cavity. No obvious abnormality is seen in the surrounding soft tissues. The inspection report is shown in Figures 4 - 5 。

[0063] Diagnosis: Western medicine diagnosis, right knee arthritis; Traditional Chinese medicine diagnosis, Bi syndrome - bone Bi syndrome.

[0064] Treatment: The hot compress treatment was carried out for 5 courses with the traditional Chinese medicine formula in Example 1, and the recovery was good. Not only can the patient walk normally, but also he can participate in heavy physical labor. The details are shown in Figure 6 。

[0065] 3. Patient 3

[0066] Lv XX2, female, 57 years old. Chief complaint: Left knee pain for more than 10 years, aggravated for half a year. Present illness history: The patient has had persistent pain and swelling in the left knee joint for more than 10 years, which is aggravated by fatigue. After being diagnosed and treated in many hospitals, the curative effect is poor, so she comes for treatment. Diagnosis of Shandong Yiyang Health Group Laiwu Central Hospital: Imaging diagnosis: 1. Degenerative osteoarthropathy of the left knee joint; 2. Grade III injury of the posterior horn of the medial meniscus of the left knee joint, grade II injury of the anterior horn of the medial meniscus and the anterior and posterior horns of the lateral meniscus; 3. Injury of the posterior cruciate ligament of the left knee joint; 4. Osteochondritis of the medial and lateral condyles of the left femur and the tibial plateau; 5. Effusion in the left knee joint. She has had a history of diabetes for more than 10 years. The tongue is light red, the coating is thin and white, and the pulse is stringy and tight. The inspection report is shown in Figures 7 - 8 。

[0067] Diagnosis: Western medicine diagnosis, left knee arthritis; Traditional Chinese medicine diagnosis: Bi syndrome - bone Bi syndrome.

[0068] Treatment: The hot compress treatment was carried out for 4 courses with the traditional Chinese medicine formula in Example 1, and the recovery was good. The pain was relieved, the swelling disappeared, and the daily living function was restored. The details are shown in Figure 9 。

[0069] The above are only the preferred embodiments of the present application and are not used to limit the present application. For those skilled in the art, various changes and modifications can be made to the present application. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A traditional Chinese medicine composition for treating osteoarthritis, characterized in that, The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 28-32 parts of Heracleum hemsleyanum, 1-5 parts of Strychnos nux-vomica preparata, 8-12 parts of Radix Aconiti preparata, 8-12 parts of Tripterygium wilfordii, 18-22 parts of Clematis chinensis, 18-22 parts of Drynaria fortunei, 13-17 parts of Piper kadsura, 10-14 parts of Liquidambar formosana, 13-17 parts of Chaenomeles sinensis, 13-17 parts of Dioscorea nipponica, 8-12 parts of Olibanum, 8-12 parts of Eupolyphaga seu Steleophaga, 13-17 parts of Epimedium brevicornu, 10-14 parts of Dipsacus asperoides, 13-17 parts of Siegesbeckia orientalis, 13-17 parts of Lycopodium clavatum and 16-20 parts of Coix lacryma-jobi.

2. The traditional Chinese medicine composition according to claim 1, wherein, The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 30 parts of Heracleum hemsleyanum, 3 parts of Strychnos nux-vomica preparata, 10 parts of Radix Aconiti preparata, 10 parts of Tripterygium wilfordii, 20 parts of Clematis chinensis, 20 parts of Drynaria fortunei, 15 parts of Piper kadsura, 12 parts of Liquidambar formosana, 15 parts of Chaenomeles sinensis, 15 parts of Dioscorea nipponica, 10 parts of Olibanum, 10 parts of Eupolyphaga seu Steleophaga, 15 parts of Epimedium brevicornu, 12 parts of Dipsacus asperoides, 15 parts of Siegesbeckia orientalis, 15 parts of Lycopodium clavatum and 18 parts of Coix lacryma-jobi.

3. Use of the traditional Chinese medicine composition according to claim 1 or 2 in the preparation of a medicament for treating osteoarthritis.

4. A drug for treating osteoarthritis, characterized in that, The medicament uses the traditional Chinese medicine composition according to claim 1 or 2 as an active ingredient.

5. The drug according to claim 4, characterized in that, The medicament may further comprise a pharmaceutically acceptable excipient.

6. The drug according to claim 4, characterized in that, The dosage form of the medicament is an aqueous solution, an ointment or a powder.

7. The medicament according to claim 6, characterized in that, The preparation method of the medicament comprises the following steps: Placing Radix Aconiti preparata in 400-600 ml of boiling water, keeping warm and soaking for 0.5-2 hours, decocting for 0.5-2 hours to obtain a Radix Aconiti preparata decoction; adding the other drugs to 3000-4000 ml of warm water and soaking for 0.5-2 hours, transferring all of them, combining with the Radix Aconiti preparata decoction, bringing to a boil over high heat, and slowly decocting over low heat for 20-80 minutes to obtain a medicament for treating osteoarthritis.

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