Traditional Chinese medicine composition for treating gallbladder and bile duct diseases as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention relates to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating gallbladder and bile duct disease, which at least comprises the following components in parts by weight: 8-10g of radix curcumae, 14-16g of pericarpium trichosanthis, 5-7g of pericarpium citri reticulatae viride, 8-10g of fructus aurantii, 14-16g of raw endothelium corneum gigeriae galli, 27-33g of lysimachia christinae hance or 8-10g of fried radix bupleuri, 22-26g of fried white paeony root and 5-7g of liquorice. The preparation method of the traditional Chinese medicine composition for treating the gallbladder and bile duct disease comprises the following steps: mixing the raw materials, adding 400ml of clear water, boiling with strong fire, continuously decocting for 30 minutes, filtering and extracting liquid medicine; adding 400ml of clear water into medicine residues, boiling with strong fire, continuing to decoct for 30 minutes, filtering and extracting medicine liquid; and combining the medicine liquid extracted twice. The traditional Chinese medicine composition for treating the gallbladder and bile duct disease has the effects of soothing liver and regulating qi, benefiting gallbladder and removing stagnation, and relieving spasm and pain, and can effectively treat liver and gallbladder qi stagnation, stagnation and turbid stagnation type chronic cholecystitis and gallbladder polyp.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and in particular to a traditional Chinese medicine composition for treating cholecystitis and bile duct disease, and a preparation method and application thereof. Background Art

[0002] Gallbladder and bile duct diseases, such as acute and chronic cholecystitis, gallstones, gallbladder polyps, gallbladder polypoid lesions, gallbladder cholesterol crystals, adenomyosis, cholangitis, common bile duct stones, intrahepatic bile duct stones, gallbladder tumors, postoperative gallstones, pancreatitis, pancreatic tumors, etc., are characterized by liver and gallbladder qi stagnation, stagnation, and turbidity. Symptoms include dull pain or fullness in the ribs, which worsens with greasy food, emotional distress, or fatigue, or pain that extends to the shoulders and back, nausea and vomiting, poor appetite, or is accompanied by acid reflux, a bitter taste in the mouth, elevated bilirubin, a red tongue with a thin, greasy coating, and a slippery or rapid pulse.

[0003] For such diseases, there is a lack of effective Chinese medicine in the prior art. Summary of the Invention

[0004] The purpose of the present invention is to provide a Chinese medicine composition for treating cholecystitis and bile duct disease, as well as a preparation method and application thereof, which can effectively treat chronic cholecystitis of the liver and gallbladder qi stagnation, stagnation of turbidity and stagnation type, and gallbladder polyps.

[0005] In order to solve the above technical problems, the present invention specifically provides the following technical solutions: The present invention provides a traditional Chinese medicine composition for treating cholecystitis and bile duct disease. The formula of the traditional Chinese medicine composition comprises at least: 8-10 grams of Curcuma aromatica, 14-16 grams of Trichosanthes root peel, 5-7 grams of Citrus aurantium, 8-10 grams of raw chicken gizzard lining, 14-16 grams of Centella asiatica or 8-10 grams of stir-fried Bupleurum chinense, 22-26 grams of stir-fried White Peony Root, and 5-7 grams of Licorice root.

[0006] Preferably, the formula of the Chinese medicine composition is as follows, in parts by weight: 9 grams of Curcuma aromatica, 15 grams of Trichosanthes root peel, 6 grams of Citrus aurantium, 9 grams of Citrus aurantium, 15 grams of raw chicken gizzard lining, 30 grams of Centella asiatica or 9 grams of stir-fried Bupleurum chinense, 24 grams of stir-fried White Peony Root, and 6 grams of Licorice root.

[0007] Preferably, the formula of the Chinese medicine composition is as follows, in parts by weight: 8 grams of Curcuma aromatica, 14 grams of Trichosanthes root peel, 5 grams of Citrus aurantium, 8 grams of Citrus aurantium, 14 grams of raw chicken gizzard lining, 27 grams of Centella asiatica or 8 grams of stir-fried Bupleurum chinense, 22 grams of stir-fried White Peony Root, and 5 grams of Licorice root.

[0008] Preferably, the formula of the Chinese medicine composition is as follows, in parts by weight: 10 grams of Curcuma, 16 grams of Trichosanthes peel, 7 grams of Citrus aurantium, 10 grams of Citrus aurantium, 16 grams of raw chicken gizzard lining, 33 grams of Centella asiatica or 10 grams of stir-fried Bupleurum, 26 grams of stir-fried White Peony Root, and 7 grams of Licorice.

[0009] Preferably, by weight, the formula of the traditional Chinese medicine composition further includes one or any several of bergamot, prepared cyperus rotundus, and citron peel.

[0010] Preferably, by weight, the formula of the traditional Chinese medicine composition further includes one or any several of red peony root, zedoary turmeric root tuber, and wood of diospyros vaccinioides.

[0011] Preferably, by weight, the formula of the traditional Chinese medicine composition further includes one or any several of hypericum japonicum, artemisia capillaris, and polygonum cuspidatum.

[0012] In the second aspect of the present invention, a preparation method of a traditional Chinese medicine composition for treating gallbladder and bile duct diseases is provided. According to the formula of the traditional Chinese medicine composition, all the traditional Chinese medicine raw materials are mixed, 400 ml of clear water is added, and after boiling with strong fire, continue to decoct for 30 minutes, and then filter to extract the medicinal liquid; Add 400 ml of clear water to the medicinal residues, boil with strong fire and continue to decoct for 30 minutes, and then filter to extract the medicinal liquid; Combine the medicinal liquids extracted twice.

[0013] In the third aspect of the present invention, an application of a traditional Chinese medicine composition for treating gallbladder and bile duct diseases is provided. The traditional Chinese medicine composition for treating gallbladder and bile duct diseases is used to treat chronic cholecystitis and gallbladder polyps of the type of stagnation of liver qi and stasis of turbid stagnation, and has the effects of soothing the liver and regulating qi, promoting bile flow and guiding stagnation, and relieving spasm and pain.

[0014] The present invention has the following beneficial effects compared with the prior art: The present invention has good effects of tonifying the kidney and replenishing essence, nourishing blood, and detoxifying and dredging collaterals.

[0015] It has the effects of soothing the liver and regulating qi, promoting bile flow and guiding stagnation, and relieving spasm and pain, and can effectively treat chronic cholecystitis and gallbladder polyps of the type of stagnation of liver qi and stasis of turbid stagnation.

[0016] Turmeric can promote qi circulation and relieve depression, and has the effect of promoting bile flow and relieving pain; green tangerine peel can soothe the liver and regulate qi, disperse stagnation and guide stasis; bitter orange can regulate qi and relieve distension, and eliminate fullness. These three herbs focus on dredging the qi mechanism of the liver and gallbladder, and are the monarch herbs.

[0017] Raw chicken gizzard-membrane can eliminate indigestion and resolve hardness, promote qi movement and protect the stomach; lysimachia christinae can remove dampness and jaundice, and promote bile flow and expel stones. These two herbs focus on clearing and promoting stagnation, and are the minister herbs. White peony root and licorice, namely paeoniae radix alba and glycyrrhizae radix, white peony root can purge the liver, astringe yin and harmonize the nutrient qi, and relieve pain in the middle energizer; licorice can remove pathogenic heat, nourish yin and blood, and harmonize the middle energizer, and can soothe the liver and spleen. The combination of the two herbs has the effects of softening the liver and harmonizing the spleen, and relieving spasm and pain, and is the assistant herb.

[0018] Trichosanthes peel can soothe the liver and promote bile flow, relieve distension and lower qi, and can lead all the herbs into the chest and hypochondrium, so it is the guiding herb. The combination of all the herbs can achieve the effects of soothing the liver and guiding stagnation, promoting bile flow and expelling stones, and relieving spasm and pain. Detailed implementation mode

[0019] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Apparently, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0020] The present invention provides a traditional Chinese medicine composition for treating gallbladder and bile duct diseases. According to parts by weight, the formula of the traditional Chinese medicine composition at least includes: 8 - 10 grams of Curcuma aromatica Salisb., 14 - 16 grams of pericarpium trichosanthis, 5 - 7 grams of green tangerine peel, 8 - 10 grams of fructus aurantii, 14 - 16 grams of raw endothelium corneum gigeriae galli, 27 - 33 grams of lysimachia christinae hance, 22 - 26 grams of stir-fried white peony root, 5 - 7 grams of licorice root.

[0021] This formula has the effects of soothing the liver and regulating qi, promoting bile flow and relieving stagnation, and alleviating spasm and pain.

[0022] Curcuma aromatica Salisb. promotes qi movement and relieves depression, and soothes the gallbladder and relieves pain; green tangerine peel soothes the liver and regulates qi, dissipates binds and relieves stagnation; fructus aurantii regulates qi and relieves fullness, relieves distension and eliminates fullness. These three herbs focus on dredging the qi mechanism of the liver and gallbladder, and are the monarch herbs.

[0023] Raw endothelium corneum gigeriae galli eliminates stagnation and hardness, promotes qi movement and protects the stomach; lysimachia christinae hance removes dampness and jaundice, promotes bile flow and expels stones. These two herbs focus on clearing and promoting digestion and relieving stagnation, and are the minister herbs. White peony root and licorice root, namely Paeoniae Radix Alba and Glycyrrhizae Radix, white peony root can purge the liver, astringe yin and harmonize the nutrient qi, relieve spasm and pain in the middle energizer; licorice root removes pathogenic heat, nourishes yin and blood, harmonizes the middle energizer, and can soothe the liver and spleen. The combination of the two herbs has the effects of softening the liver and soothing the spleen, and alleviating spasm and pain, and is the assistant herb.

[0024] Pericarpium trichosanthis soothes the liver and promotes bile flow, widens the chest and descends qi, and can lead all the herbs into the chest and hypochondrium, so it is the envoy herb. The combination of all the herbs together exerts the effects of soothing the liver and relieving stagnation, promoting bile flow and expelling stones, and alleviating spasm and pain.

[0025] The indications of this traditional Chinese medicine composition are senile lower energizer diseases, such as prostatic hyperplasia, pelvic floor diseases, kidney stones, urinary tract stones, renal tumors, bladder tumors, chronic urinary tract infections, gynecological tumors, colonic polyps, rectal mucosal prolapse, lumbar disc herniation, knee osteoarthritis, heel pain, etc., and those with syndrome of deficiency of kidney essence, weakness of qi transformation in the lower energizer, stasis and turbidity binding. Common symptoms such as frequent urination at night, or frequent and urgent urination, abdominal distension and discomfort, loose stools or difficult defecation, accompanied by dizziness, tinnitus, fatigue, poor sleep, soreness and weakness of the waist and knees, cold hands and feet, dull red or cracked tongue, thin white coating on the tongue, and thready and unsmooth pulse.

[0026] Example 1: The formula of the traditional Chinese medicine composition is 9 grams of Curcuma aromatica Salisb., 15 grams of pericarpium trichosanthis, 6 grams of green tangerine peel, 9 grams of fructus aurantii, 15 grams of raw endothelium corneum gigeriae galli, either 30 grams of lysimachia christinae hance or 9 grams of stir-fried bupleurum chinense, 24 grams of stir-fried white peony root, 6 grams of licorice root.

[0027] Example 2: The formula of the Chinese medicine composition is 8 grams of turmeric, 14 grams of trichosanthes peel, 5 grams of green peel, 8 grams of aurantium, 14 grams of raw chicken gizzard lining, 27 grams of Lysimachia chinensis or 8 grams of stir-fried bupleurum, 22 grams of stir-fried white peony root, and 5 grams of liquorice.

[0028] Example 3: The formula of the Chinese medicine composition is 10 grams of turmeric, 16 grams of trichosanthes peel, 7 grams of green peel, 10 grams of aurantium, 16 grams of raw chicken gizzard lining, 33 grams of Lysimachia chinensis or 10 grams of stir-fried bupleurum, 26 grams of stir-fried white peony root, and 7 grams of liquorice.

[0029] The preparation method comprises the following steps: mixing all the Chinese medicinal raw materials according to the formula of the Chinese medicinal composition, adding 400 ml of water, boiling over high heat, and then decocting for 30 minutes, filtering and extracting the medicinal liquid; Add 400ml of water to the residue, bring to a boil over high heat, and continue decocting for 30 minutes, then filter and extract the medicinal liquid; Combine the two extraction solutions.

[0030] Through the analysis of the pathogenesis of gallbladder and bile duct disease, liver and gallbladder qi stagnation and poor qi movement are the pathological basis of this disease, while damp-heat stagnation and evil turbidity stagnation are the key to the pathogenesis of this disease.

[0031] Stagnation of liver qi hinders bile excretion, leading to obstructed bile excretion. Over time, this accumulation can form stones. This prolonged liver stagnation can transform into fire, which fumigates the liver and gallbladder, simmering the bile and causing it to condense into turbidity. The gallbladder, the central viscera of essence, functions to promote circulation. "Lei Zheng Zhi Cai: Nei Jing Zong Yao" states, "The six viscera, which transmit and transform substances but fail to store them, are full but unable to be full. Therefore, promoting circulation is the key to nourishment."

[0032] Based on an understanding of the pathogenesis and syndrome differentiation of this disease, the following four aspects should be considered: First, focusing on "unblocking" and "descending" the qi, focusing on regulating the qi; second, treating both the liver and gallbladder, rectifying the root cause and clearing the source, focusing on regulating the liver to strengthen the foundation; third, promoting bile secretion and expelling stones to allow stagnant turbid pathogens to exit; and fourth, clearing heat and dampness, promoting qi and relieving pain. In summary, soothing the liver and regulating qi is the fundamental goal, promoting bile secretion and expelling stones is the priority, and relieving acute pain is the ultimate goal.

[0033] The following provides specific clinical data: Yu, a 49-year-old male, presented with a chief complaint of nausea and vomiting for over three months. He reported experiencing nausea and vomiting for over three months, particularly in the morning, along with occasional discomfort and fullness in the right flank, especially with exertion. He also experienced occasional acid reflux, no phlegm in his throat, normal appetite, restful sleep, and soft stools. He had a history of gallstones, pulmonary nodules, colon polyps, chronic gastritis, and cardia inflammation.

[0034] Examination: Lack of energy, moderate physique, normal heart and lung auscultation, no obvious percussion tenderness in the right flank, chubby tongue with teeth marks on the edges, thin yellow greasy fur, and a stringy pulse. A recent abdominal ultrasound at a local hospital revealed a rough gallbladder wall and several bright masses with acoustic shadows within the cavity, the largest of which was 1.8 cm. The results suggest multiple gallstones. Syndrome differentiation: liver depression, qi stagnation, and internal accumulation of damp heat.

[0035] Taking Example 1 as the preferred one, the traditional Chinese medicine composition for treating gallbladder and bile duct diseases is used with modification for treatment.

[0036] Prescription: The formula of the traditional Chinese medicine composition is 9 grams of curcuma aromatica, 15 grams of pericarpium trichosanthis, 6 grams of green tangerine peel, 9 grams of fructus aurantii, 15 grams of raw chicken gizzard-membrane, 30 grams of lysimachia christinae, or 9 grams of stir-fried bupleurum chinense, 24 grams of stir-fried white peony root, and 6 grams of licorice root.

[0037] After taking the medicine for 14 doses (taking 1 dose in the morning and 1 dose in the afternoon respectively), go for a follow-up visit: The distending pain in the right hypochondrium disappears, the degree of nausea is alleviated compared with before, there is a little phlegm in the throat, and the tongue coating turns thinner.

[0038] When specifically prescribing medicine, it is necessary to pay attention to careful syndrome differentiation and flexible prescription. For gallbladder and bile duct stones, this formula is more suitable for those with relatively small stones and has a good effect on stone expulsion. For patients with gallbladder stones exceeding 1 centimeter, lysimachia christinae should be changed to stir-fried bupleurum chinense, and raw chicken gizzard-membrane should be changed to stir-fried chicken gizzard-membrane. The function is mainly to soothe the liver and promote bile flow, and strong stone expulsion is not advocated to prevent stone incarceration. The above treatment case belongs to this example. In addition, green tangerine peel can be replaced by dried tangerine peel, or green tangerine peel and dried tangerine peel can be used together. If there is qi stagnation and obvious abdominal distension, add fingered citron, prepared cyperus rotundus, and citron peel, etc.; if there is blood stasis and ecchymosis on the edge of the tongue, add red peony root, zedoary turmeric, and radix broussonetiae papyriferae, etc.; if there is damp-heat and yellow and greasy tongue coating, add herba hyperici japonici, artemisia capillaris, and polygonum cuspidatum, etc.

[0039] The above embodiments are only exemplary embodiments of the present application and are not used to limit the present application. The protection scope of the present application is defined by the claims. Those skilled in the art can make various modifications or equivalent replacements within the essence and protection scope of the present application, and such modifications or equivalent replacements should also be regarded as falling within the protection scope of the present application.

Claims

1. A traditional Chinese medicine composition for treating gallbladder and bile duct diseases, characterized in that, Calculated by weight parts, the formula of the traditional Chinese medicine composition comprises at least: 8 - 10 grams of Curcuma aromatica Salisb., 14 - 16 grams of pericarpium trichosanthis, 5 - 7 grams of green tangerine peel, 8 - 10 grams of fructus aurantii, 14 - 16 grams of endothelium corneum gigeriae galli, 27 - 33 grams of lysimachia christinae hance or 8 - 10 grams of bupleurum chinense DC. stir-fried, 22 - 26 grams of white peony root stir-fried, 5 - 7 grams of liquorice root.

2. The traditional Chinese medicine composition for treating gallbladder and bile duct diseases according to claim 1, wherein, Calculated by weight parts, the formula of the traditional Chinese medicine composition is: 9 grams of Curcuma aromatica Salisb., 15 grams of pericarpium trichosanthis, 6 grams of green tangerine peel, 9 grams of fructus aurantii, 15 grams of endothelium corneum gigeriae galli, 30 grams of lysimachia christinae hance or 9 grams of bupleurum chinense DC. stir-fried, 24 grams of white peony root stir-fried, 6 grams of liquorice root.

3. The traditional Chinese medicine composition for treating cholecystocholangiopathy according to claim 1, wherein Calculated by weight parts, the formula of the traditional Chinese medicine composition is: 8 grams of Curcuma aromatica Salisb., 14 grams of pericarpium trichosanthis, 5 grams of green tangerine peel, 8 grams of fructus aurantii, 14 grams of endothelium corneum gigeriae galli, lysimachia christinae hance or 8 grams of bupleurum chinense DC. stir-fried, 22 grams of white peony root stir-fried, 5 grams of liquorice root.

4. A traditional Chinese medicine composition for treating gallbladder and bile duct diseases according to claim 1, wherein, Calculated by weight parts, the formula of the traditional Chinese medicine composition is: 10 grams of Curcuma aromatica Salisb., 16 grams of pericarpium trichosanthis, 7 grams of green tangerine peel, 10 grams of fructus aurantii, 16 grams of endothelium corneum gigeriae galli, 33 grams of lysimachia christinae hance or 10 grams of bupleurum chinense DC. stir-fried, 26 grams of white peony root stir-fried, 7 grams of liquorice root.

5. The Chinese medicinal composition for treating cholecystocholangiopathy according to claim 1, wherein Calculated by weight parts, the formula of the traditional Chinese medicine composition further comprises one or any combination of fingered citron, prepared cyperus rotundus l., pericarpium citri medicae.

6. The Chinese medicine composition for treating gallbladder and bile duct diseases according to claim 1, wherein Calculated by weight parts, the formula of the traditional Chinese medicine composition further comprises one or any combination of red peony root, zedoary turmeric, oldhamia scandens.

7. The traditional Chinese medicine composition for treating gallbladder and bile duct diseases according to claim 1, wherein, Calculated by weight parts, the formula of the traditional Chinese medicine composition further comprises one or any combination of hypericum japonicum thunb., artemisia capillaris thunb., polygonum cuspidatum sieb. et zucc.

8. A preparation method of the traditional Chinese medicine composition for treating cholecystocholangiopathy according to any one of claims 1-7, characterized in that, According to the formula of the traditional Chinese medicine composition, mix all the traditional Chinese medicine raw materials, add 400 ml of clear water, bring to a boil over high heat and continue to decoct for 30 minutes, then filter to extract the medicinal liquid; Add 400 ml of clear water to the medicinal residues, bring to a boil over high heat and continue to decoct for 30 minutes, then filter to extract the medicinal liquid; Combine the medicinal liquids extracted twice.

9. Use of a traditional Chinese medicine composition for treating cholecystocholangiopathy according to any one of claims 1-7, characterized in that, The traditional Chinese medicine composition for treating gallbladder and bile duct diseases is used for treating chronic cholecystitis and gallbladder polyps of liver - qi stagnation and stasis - turbidity stagnation type, and has the effects of soothing the liver and regulating qi, promoting bile flow and inducing diuresis, relieving spasm and pain.