Formula helpful for improving sleep and preparation method thereof

Abstract

The invention belongs to the technical field of health-care products, and particularly relates to a formula helpful for improving sleep and a preparation method thereof. Comprising the following raw material components in parts by weight: 90-110 parts of spina date seed powder, 45-55 parts of casein hydrolysate peptide powder, 15-22 parts of gamma-aminobutyric acid, 18-22 parts of lucid ganoderma powder, 15-22 parts of lily powder, 18-20 parts of poria cocos powder, 12-15 parts of tea leaf theanine and 1-4 parts of lactobacillus plantarum JYLP-326. According to the formula for improving sleep provided by the invention, the limitation of an existing insomnia treatment means is broken through through a three-dimensional synergistic network of traditional Chinese medicines, probiotics and functional components, and the formula realizes systematic improvement on insomnia core symptoms through multi-channel synergy of nerve regulation, intestinal brain axis intervention and immune balance, namely rapid induction of sleep.

Description

Technical Field

[0001] The present invention belongs to the technical field of health products, and particularly relates to a formula for helping improve sleep and its preparation method. Background Art

[0002] Insomnia refers to a chronic disease in which people have difficulty falling asleep and insufficient sleep time in daily life. With the continuous acceleration of the national life rhythm and the increase in work pressure, the proportion of the insomnia population has been increasing year by year. According to a survey by the World Health Organization (WHO), approximately one-third of the people worldwide have insomnia symptoms or sleep function disorders. Research has found that insomnia can cause daily phenomena such as memory loss and inattention, cause irreversible damage to the brain, and it is a complication of various cardiovascular and cerebrovascular diseases and neurodegenerative diseases.

[0003] Currently, for the problem of insomnia, we have diversified coping strategies. Among them, non-drug therapies such as cognitive behavioral therapy and physical therapy help patients adjust their sleep patterns in their unique ways. In terms of drug therapy, it covers a variety of options such as benzodiazepine sleeping pills, non-benzodiazepine sleeping pills, and traditional Chinese herbal medicine therapy. Given the current mainstream sleeping drugs on the market, such as benzodiazepines and non-benzodiazepines, although they can take effect quickly and have significant effects, they are accompanied by significant side effects and potential risks of dependence and addiction; on the contrary, although traditional Chinese herbal medicine for treating insomnia has high safety, it faces challenges such as low absorption and utilization rate of drug active ingredients, slow onset of efficacy, and long treatment cycles. To overcome these limitations, the present invention innovatively proposes a formula for helping improve sleep. Summary of the Invention

[0004] In view of the above deficiencies in the prior art, the present invention provides a formula for helping improve sleep and its preparation method to solve the problems in the above background art.

[0005] To solve the above technical problems, the present invention adopts the following technical solutions:

[0006] A formula for helping improve sleep, comprising the following raw material components in parts by weight: 90 - 110 parts of wild jujube seed powder, 45 - 55 parts of hydrolyzed casein peptide powder, 15 - 22 parts of γ-aminobutyric acid, 18 - 22 parts of ganoderma lucidum powder, 15 - 22 parts of lily powder, 18 - 20 parts of poria cocos powder, 12 - 15 parts of theanine, and 1 - 4 parts of Lactobacillus plantarum JYLP - 326.

[0007] Furthermore, it further comprises the following raw material components in parts by weight: 200 - 300 parts of sweetener and 1 - 3 parts of lubricant.

[0008] Furthermore, the sweetener is sorbitol and the lubricant is magnesium stearate.

[0009] Furthermore, the invention comprises the following raw material components in parts by weight: 250 parts of sorbitol, 100 parts of jujube kernel powder, 50 parts of hydrolyzed casein peptide powder, 20 parts of gamma-aminobutyric acid, 20 parts of ganoderma lucidum powder, 20 parts of lily powder, 20 parts of poria powder, 15 parts of tea theanine, 3 parts of Lactobacillus plantarum JYLP-326, and 2 parts of magnesium stearate.

[0010] The raw material sources of the present invention are as follows:

[0011] Source of sour jujube kernel powder: dried mature seeds of sour jujube of the Rhamnaceae family, which are made by cleaning, drying and crushing.

[0012] Source of Ganoderma lucidum powder: The dried fruiting bodies of Ganoderma lucidum or Ganoderma rubrum of the Polyporaceae family are harvested, impurities removed and crushed.

[0013] Source of lily powder: dried fleshy scale leaves of Lilium lily, Lilium or Lilium tiliaceum, which are plants of the Liliaceae family, are washed, dried and ground into powder.

[0014] Source of Poria powder: The dried sclerotia of the Polyporaceae fungus Poria cocos are dug, desilted, dried and then crushed.

[0015] Source of γ-aminobutyric acid: Microbial fermentation method: It is produced by fermenting glucose using lactic acid bacteria, yeast and other strains (such as Lactobacillus brevis), and is the main source of food.

[0016] Source of tea theanine: extracted from green tea (such as Longjing and Tieguanyin): separated and purified through water extraction, resin adsorption and other processes.

[0017] Hydrolyzed Casein Peptide Powder Source:

[0018] Bovine milk casein is hydrolyzed by proteases (such as trypsin), membrane separation, and spray drying to obtain a protein rich in active peptides such as α-lactalbumin and β-casomorphin.

[0019] Source of Lactobacillus plantarum JYLP-326: Isolated from traditional fermented glutinous rice in Bama, Guangxi, identified by the 16SrRNA gene of the Institute of Microbiology, Chinese Academy of Sciences, as a probiotic native to the human body. It is prepared into bacterial powder through enrichment, fermentation, and low-temperature freeze-drying.

[0020] Furthermore, the dosage form of the formula is tablets, and 1 part by mass of the raw material in each tablet is 1 mg.

[0021] The present invention also provides a method for preparing a formula that helps improve sleep, the preparation method specifically comprising: weighing each raw material in parts by weight, placing all raw materials except magnesium stearate into a three-dimensional mixer and mixing;

[0022] Add water to the uniformly mixed material and stir to make soft material. Extrude the soft material through a 18-20 mesh sieve to make wet granules of uniform size.

[0023] Dry the wet granules at a drying temperature of 50-60 °C for 1-2 hours. Screen the dried granules through a 16-18 mesh sieve for granulation.

[0024] Put the granulated granules and magnesium stearate into a two-dimensional mixer for mixing. The mixing speed of the two-dimensional mixer is 20-30 revolutions per minute, and the mixing time is 10-15 minutes. Press the total mixed material into tablets through a tablet press.

[0025] Compared with the prior art, the present invention has the following beneficial effects:

[0026] 1. The sleep improvement formula provided by the present invention breaks through the limitations of existing insomnia treatment methods through the three-dimensional synergistic network of "traditional Chinese medicine - probiotics - functional components". The formula synergistically acts through multiple pathways of "neural regulation - gut-brain axis intervention - immune balance" to achieve systematic improvement of the core symptoms of insomnia: Rapidly induce sleep: The saponin component in the semen ziziphi spinosae powder activates the receptor, and γ-aminobutyric acid directly supplements inhibitory neurotransmitters. The combination of the two rapidly reduces the excitability of the cerebral cortex and shortens the sleep onset time. Compared with traditional single traditional Chinese medicine prescriptions, the onset speed of this formula is improved.

[0027] 2. Prolong the deep sleep duration: Lactobacillus plantarum JYLP-326 increases the production of short-chain fatty acids through gut-brain axis regulation, and ganoderma lucidum polysaccharide inhibits pro-inflammatory factors in the brain, jointly increasing the proportion of deep sleep and improving the sleep depth.

[0028] 3. Improve sleep stability: L-theanine and hydrolyzed casein peptide powder synergistically regulate the 5-hydroxytryptaminergic neural pathway, reduce the number of night awakenings, and make the sleep cycle more continuous. Specific embodiments

[0029] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0030] Example 1:

[0031] The sleep improvement formula of this example is prepared from the following components: 90 parts of semen ziziphi spinosae powder, 45 parts of hydrolyzed casein peptide powder, 15 parts of γ-aminobutyric acid, 18 parts of ganoderma lucidum powder, 15 parts of lilium brownii powder, 18 parts of poria cocos powder, 12 parts of L-theanine, and 1 part of Lactobacillus plantarum JYLP-326

[0032] The preparation method is as follows:

[0033] I. Raw material preparation

[0034] Accurate weighing: According to the formula requirements, use high-precision weighing instruments to weigh 90 g of wild jujube seed powder, 45 g of hydrolyzed casein peptide powder, 15 g of γ-aminobutyric acid, 18 g of ganoderma lucidum powder, 15 g of lily powder, 18 g of poria cocos powder, 12 g of theanine, 1 g of Lactobacillus plantarum JYLP-326, 250 g of sorbitol, and 2 g of magnesium stearate to prepare 10,000 tablets.

[0035] Raw material pretreatment: Check the quality of each raw material to ensure that there are no problems such as caking and deterioration. If there are large particles in powdery raw materials such as wild jujube seed powder and ganoderma lucidum powder, they can be sieved to make the particle size uniform, which is conducive to subsequent uniform mixing.

[0036] II. Mixing operation

[0037] Preliminary mixing: Put all the weighed raw materials except magnesium stearate, namely sorbitol, wild jujube seed powder, hydrolyzed casein peptide powder, γ-aminobutyric acid, ganoderma lucidum powder, lily powder, poria cocos powder, theanine, and Lactobacillus plantarum JYLP-326, into a three-dimensional mixer. Set the mixing speed of the three-dimensional mixer to 30 - 50 revolutions per minute and the mixing time to 20 - 30 minutes. During the mixing process, the unique movement mode of the three-dimensional mixer can make the materials tumble and blend in all directions in space to ensure that all components are fully and evenly dispersed.

[0038] Check the mixing effect: After mixing, randomly select a small amount of materials for observation to check whether there are situations such as uneven color and particle size. If it is found that the mixing is not sufficient, the mixing time can be appropriately extended until the materials are evenly mixed.

[0039] III. Granulation process

[0040] Prepare soft material: Slowly add an appropriate amount of purified water to the evenly mixed materials while stirring. Control the stirring speed moderately to avoid splashing or caking of the materials due to too fast speed. Keep stirring until a soft material that meets the standard of "forming a ball when held in the hand and dispersing when gently pressed" is made. The amount of water added in this process needs to be strictly controlled. If the amount of water added is too small, the soft material is difficult to form; if the amount of water added is too large, the soft material has too high viscosity and is not conducive to subsequent granulation.

[0041] Granulation: Granulate the prepared soft material through a 18 - 20 mesh sieve. Equipment such as a rocking granulator can be used to make the soft material extrude through the sieve to form wet granules with relatively uniform sizes. During the granulation process, pay attention to keeping the sieve clean to avoid sieve blockage affecting the granulation efficiency and particle quality.

[0042] IV. Drying treatment

[0043] Transfer the obtained wet granules to a hot air circulation drying oven for drying. Set the drying temperature at 50 - 60 °C and the drying time at 1 - 2 hours. During drying, the hot air in the hot air circulation drying oven evenly passes through the material, causing the moisture in the wet granules to evaporate rapidly. Regularly detect the moisture content of the granules, and stop drying when the moisture content of the granules reaches 3 - 5%. Avoid over-drying which may cause the granules to become brittle and fragile, or insufficient drying which may affect the stability of the tablets.

[0044] V. Granulation operation

[0045] Pass the dried granules through a 16 - 18 mesh sieve for granulation. The granulation process can remove the lumps and sticky granules that may be generated during drying, making the granule size more uniform, providing a good material basis for subsequent tableting. The granulated granules should have good fluidity for easy filling into the tablet press mold.

[0046] VI. Total mixing step

[0047] Put the granulated granules and magnesium stearate into a two-dimensional mixer. Set the mixing rotation speed of the two-dimensional mixer at 20 - 30 revolutions per minute and the mixing time at 10 - 15 minutes. As a lubricant, magnesium stearate is evenly distributed on the surface of the granules through the stirring action of the two-dimensional mixer, reducing the friction between the granules and between the granules and the tablet press mold, enabling the granules to be smoothly filled into the mold during tableting, ensuring that the weight difference during tableting meets the requirements, and avoiding problems such as sticking to the punch.

[0048] VII. Tablet forming

[0049] Perform tableting operation using a rotary tablet press. Select a suitable mold according to the specifications of the tablets to be prepared and install it on the tablet press. Feed the total mixed material into the hopper of the tablet press, and control the weight difference of the tablets within ±5% by adjusting parameters such as the pressure and rotation speed of the tablet press, and press the material into tablets that meet the specification requirements. During tableting, monitor quality indicators such as tablet weight, hardness, and appearance in real time, and adjust the tablet press parameters in a timely manner to ensure the stable quality and smooth appearance of the pressed tablets.

[0050] Specification: Each tablet contains 90 mg of semen ziziphi spinosae powder, 45 mg of hydrolyzed casein peptide powder, 15 mg of γ-aminobutyric acid, 18 mg of ganoderma lucidum powder, 15 mg of lilium brownii powder, 18 mg of poria cocos powder, 12 mg of L-theanine, 1 mg of lactobacillus plantarum JYLP-326, 250 mg of sorbitol, and 2 mg of magnesium stearate.

[0051] Example 2:

[0052] The formula for improving sleep in this embodiment is prepared from the following components: 110 parts of wild jujube seed powder, 55 parts of hydrolyzed casein peptide powder, 22 parts of γ-aminobutyric acid, 22 parts of ganoderma lucidum powder, 22 parts of lily powder, 20 parts of poria cocos powder, 15 parts of L-theanine, and 4 parts of Lactobacillus plantarum JYLP-326.

[0053] Its preparation method is similar to that of Example 1.

[0054] Example 3:

[0055] The formula for improving sleep in this embodiment is prepared from the following components: 100 parts of wild jujube seed powder, 50 parts of hydrolyzed casein peptide powder, 20 parts of γ-aminobutyric acid, 20 parts of ganoderma lucidum powder, 20 parts of lily powder, 20 parts of poria cocos powder, 15 parts of L-theanine, and 3 parts of Lactobacillus plantarum JYLP-326.

[0056] Its preparation method is similar to that of Example 1.

[0057] Example 4:

[0058] The formula for improving sleep in this embodiment is prepared from the following components: 70 parts of wild jujube seed powder, 35 parts of hydrolyzed casein peptide powder, 10 parts of γ-aminobutyric acid, 10 parts of ganoderma lucidum powder, 10 parts of lily powder, 10 parts of poria cocos powder, 10 parts of L-theanine, and 1 part of Lactobacillus plantarum JYLP-326.

[0059] Its preparation method is similar to that of Example 1.

[0060] Example 5:

[0061] The formula for improving sleep in this embodiment is prepared from the following components: 130 parts of wild jujube seed powder, 70 parts of hydrolyzed casein peptide powder, 30 parts of γ-aminobutyric acid, 30 parts of ganoderma lucidum powder, 30 parts of lily powder, 30 parts of poria cocos powder, 25 parts of L-theanine, and 6 parts of Lactobacillus plantarum JYLP-326.

[0062] Its preparation method is similar to that of Example 1.

[0063] Comparative Example 1;

[0064] The formula for improving sleep is prepared from the following components: 100 parts of wild jujube seed powder, 50 parts of hydrolyzed casein peptide powder, 20 parts of γ-aminobutyric acid, 20 parts of ganoderma lucidum powder, 20 parts of lily powder, 20 parts of poria cocos powder, 15 parts of L-theanine, without Lactobacillus plantarum JYLP-326;

[0065] Its preparation method is similar to that of Example 1.

[0066] Comparative Example 2;

[0067] A sleep-improving formula is prepared from the following components: 50 parts of hydrolyzed casein peptide powder, 20 parts of γ-aminobutyric acid, 20 parts of Ganoderma lucidum powder, 20 parts of Lily powder, 20 parts of Poria cocos powder, 15 parts of L-theanine, 3 parts of Lactobacillus plantarum JYLP-326, without Ziziphus jujuba seed powder;

[0068] Its preparation method is similar to that of Example 1.

[0069] Comparative Example 3;

[0070] A sleep-improving formula is prepared from the following components: 35 parts of hydrolyzed casein peptide powder, 10 parts of Ganoderma lucidum powder, 10 parts of Lily powder, 10 parts of Poria cocos powder, 10 parts of L-theanine, out of range and low dose (70 parts of Ziziphus jujuba seed powder, 10 parts of γ-aminobutyric acid, 1 part of Lactobacillus plantarum JYLP-326);

[0071] Its preparation method is similar to that of Example 1.

[0072] Comparative Example 4;

[0073] A sleep-improving formula is prepared from the following components: 70 parts of hydrolyzed casein peptide powder, 30 parts of Ganoderma lucidum powder, 30 parts of Lily powder, 30 parts of Poria cocos powder, 25 parts of L-theanine, out of range and high dose (130 parts of Ziziphus jujuba seed powder, 30 parts of γ-aminobutyric acid, 6 parts of Lactobacillus plantarum JYLP-326);

[0074] Its preparation method is similar to that of Example 1.

[0075] Performance test

[0076] Experimental method: 140 Kunming mice were randomly divided into 7 groups (Examples 1-3, Examples 4-5, Comparative Examples 1-4), with 20 mice in each group. A sleep disorder model was induced by p-chlorophenylalanine (PCPA).

[0077] Dosing dose: Gavage at 0.2 mL / 10 g body weight for 7 consecutive days. Sleep indicators were detected 1 hour after the last dose.

[0078] Blank control group; Healthy mice were gavaged with an equal volume of normal saline.

[0079] Model control group; Model mice (intraperitoneally injected with PCPA) were gavaged with an equal volume of normal saline.

[0080] Positive control group; Model mice were gavaged with estazolam.

[0081] Experimental record

[0082] Table 1 is a data table of examples and comparative examples;

[0083] Definition of sleep latency: The time from turning off the light or injecting the drug to entering continuous sleep (continuous immobility ≥ 120 seconds), which reflects the ease of falling asleep.

[0084] Definition of total sleep time: The cumulative sleep duration within 12 hours of the dark period, which reflects the sleep maintenance ability.

[0085] Definition of deep sleep proportion: The proportion of deep sleep in total sleep, which is a core indicator for measuring sleep quality (deep sleep is closely related to physical recovery and memory consolidation).

[0086] Definition of awakening times: The number of awakenings from sleep within 12 hours, which reflects sleep stability.

[0087]

[0088] Table 1

[0089] Table 2 is the experimental record table with an added control group.

[0090] [[ID=z1]]

[0091] Table 2 <z

[0092] It can be seen from Table 1 and Table 2 that the sleep latency of the Example 3 group is the shortest (18.6 - 18.9 min), which is about 50% shorter than that of the model control group (38.6 min), and is comparable to that of the positive control drug (estazolam, 19.2 min), proving that the formula can rapidly induce sleep. The total sleep time (195 - 212 min) and deep sleep proportion (29.1% - 34.8%) of the Example 3 group are both close to those of the blank control group (205 min / 31.2%), and are 74% - 76% higher than those of the model control group (112 min / 16.5%), and are superior to those of the positive control group (188 min / 27.8%). Mechanism prediction: Through the synergy of multiple components, the formula not only prolongs the sleep time, but also significantly increases the proportion of deep sleep, which is different from the forced prolongation of light sleep by chemical drugs.

[0093] The deep sleep proportion (21.3%) and total sleep time (145 min) of the Comparative Example 1 group are significantly lower than those of the Example 3 group, indicating that probiotics are crucial for improving deep sleep and sleep duration by regulating the intestinal microecology and neurotransmitters. The sleep latency (34.8 min) and awakening times (8.0 times / 12 h) of the Comparative Example 2 group are close to those of the model control group, proving that jujuboside has a decisive role in rapidly inhibiting the excitability of the cerebral cortex and stabilizing the sleep structure.

[0094] In Examples 1 - 3 groups, as the component content increased, the curative effect gradually improved, the latency shortened, and the deep sleep increased. Among them, the effect of Example 3 group was the best; in Examples 4 - 5 groups (out - of - range low / high doses), the curative effect decreased, indicating that the component ratio needs to be strictly controlled within the scope of the invention to avoid antagonistic effects caused by dose imbalance.

[0095] There was no significant difference in sleep latency and total sleep time between the Example 3 group and the positive control group, but the proportion of deep sleep was higher, suggesting that the formula was closer to the natural sleep pattern and avoided the interference of chemical drugs on the sleep structure.

[0096] The data of the comparative examples showed that the absence of any core component or the use of a single component (such as only GABA or probiotics) could not achieve the effect of the example group, proving that the formula broke through the limitation of "single - component superposition" of existing products through the three - dimensional synergistic network of "traditional Chinese medicine - probiotics - functional components" and realized the linkage regulation of multiple systems of nerves, intestines, and immunity.

[0097] Research conclusions

[0098] Semen Ziziphi Spinosae powder: Activates the GABA - energy neural pathway, inhibits the excitability of the cerebral cortex, rapidly reduces the conduction of awakening signals, and shortens the sleep - onset time. Ganoderma lucidum powder and Lilium brownii powder: Regulate the norepinephrine and 5 - hydroxytryptamine (5 - HT) pathways, relieve anxiety, prolong the sleep duration, and improve sleep stability. Poria cocos powder: Improves the internal environment by strengthening the spleen and promoting diuresis to eliminate the pathological factors affecting sleep indirectly. Intestinal microecological reconstruction: Inhibits harmful bacteria, promotes the proliferation of beneficial bacteria, generates metabolites such as short - chain fatty acids, and acts on the brain through the vagus nerve to regulate sleep - related neurotransmitters. Neurotransmitter synthesis: The strain itself synthesizes GABA and supplements the central inhibitory neurotransmitter through the "intestine - blood - brain" pathway to strengthen the sedative effect. Traditional Chinese medicine synergy: Poria cocos powder, as a prebiotic, enhances the colonization of probiotics, and jujuboside is metabolized by the strain into a more active aglycone, forming a "traditional Chinese medicine - probiotic" metabolic interaction. γ - aminobutyric acid (GABA): Exogenous supplementation of inhibitory neurotransmitters forms a "dual - source inhibition" with the GABA - enhancing effect of Semen Ziziphi Spinosae, rapidly reducing nerve excitability. L - theanine in tea relieves stress - related insomnia and forms a "fast - slow combination" synergistic mode with GABA. Hydrolyzed casein peptide powder: Releases milk - derived sedative peptides, binds to the benzodiazepine receptor non - dependently, prolongs the sleep duration, and improves sleep depth.

[0099] Through the three-dimensional synergy of multiple components, multiple targets, and multiple pathways, this formula has achieved an upgrade in insomnia treatment from "symptom suppression" to "system repair": Efficiency breakthrough: By integrating the "rapid sedation" of traditional Chinese medicine, the "gut-brain axis regulation" of probiotics, and the "precision inhibition" of functional ingredients, it avoids the limitations of single-component effects and enhances the overall efficacy. Safety upgrade: Abandoning the excessive intervention of chemical drugs on the central nervous system, through the synergistic regulation of natural ingredients, it reduces the risk of side effects and is suitable for long-term use. Mechanism innovation: For the first time, gut-brain axis intervention is incorporated into the insomnia treatment system, revealing the internal relationship between "gut health - neural homeostasis - sleep quality", providing a new direction for insomnia treatment.

[0100] The above is the preferred embodiment of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the principle of the present invention, several improvements and modifications can be made, and these improvements and modifications should also be regarded as the protection scope of the present invention.

Claims

1. A formula that helps improve sleep, characterized in that: It includes the following raw material components in parts by weight: 90 - 110 parts of wild jujube seed powder, 45 - 55 parts of hydrolyzed casein peptide powder, 15 - 22 parts of γ-aminobutyric acid, 18 - 22 parts of ganoderma lucidum powder, 15 - 22 parts of lily powder, 18 - 20 parts of poria cocos powder, 12 - 15 parts of theanine, and 1 - 4 parts of Lactobacillus plantarum JYLP-326.

2. The formula for helping to improve sleep according to claim 1, characterized in that: It also includes the following raw material components in parts by weight: 200 - 300 parts of sweetener and 1 - 3 parts of lubricant.

3. The formula for helping to improve sleep according to claim 2, characterized in that: The sweetener is sorbitol and the lubricant is magnesium stearate.

4. A formula for helping to improve sleep according to claim 3, characterized in that: It includes the following raw material components in parts by weight: 250 parts of sorbitol, 100 parts of wild jujube seed powder, 50 parts of hydrolyzed casein peptide powder, 20 parts of γ-aminobutyric acid, 20 parts of ganoderma lucidum powder, 20 parts of lily powder, 20 parts of poria cocos powder, 15 parts of theanine, 3 parts of Lactobacillus plantarum JYLP-326, and 2 parts of magnesium stearate.

5. A formula for helping to improve sleep according to claim 4, characterized in that: The dosage form of the said formula is tablets, and 1 part of the raw material mass fraction in each tablet is 1 mg.

6. The preparation method of a formula helpful for improving sleep according to claim 5, characterized in that: The specific preparation method is as follows: Weigh each raw material by weight, put all the raw materials except magnesium stearate into a three-dimensional mixer for mixing; Add water to the uniformly mixed materials and stir to make soft materials, extrude the soft materials through an 18 - 20 mesh sieve to make wet granules of uniform size; Dry the wet granules, the drying temperature is 50 - 60 °C, the drying time is 1 - 2 hours, and screen the dried granules through a 16 - 18 mesh sieve for granulation; Put the granulated granules and magnesium stearate into a two-dimensional mixer for mixing, the mixing speed of the two-dimensional mixer is 20 - 30 revolutions per minute, the mixing time is 10 - 15 minutes, and press the total mixed materials into tablets through a tablet press.

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