Porous carrier, buccal product and preparation method thereof

Abstract

The invention discloses a porous carrier, a buccal product and a preparation method of the porous carrier. The porous carrier is particles prepared from materials including microcrystalline cellulose, porous silicon dioxide and copovidone. The three materials of the porous carrier, the microcrystalline cellulose, the porous silicon dioxide and the copovidone can significantly increase the adsorption capacity and the stability of the essence through different adsorption mechanisms, so that the fragrance attenuation of the essence can be reduced, and the fragrance durability is improved.

Description

Technical Field

[0001] The present application relates to the technical field of nicotine products and their excipients, and particularly relates to a porous carrier, an oral product and a preparation method thereof. Background Art

[0002] An oral nicotine product is a product containing an active substance (nicotine or its derivative), usually in the form of powder, film, sachet, chewing gum, etc., placed in the oral cavity, then dissolved and released the active substance, and absorbed through the oral mucosa, so as to relieve nicotine withdrawal symptoms during smoking cessation. The oral nicotine product is a new type of rapid oral nicotine delivery system, which has the advantages of accurate dosage, rapid onset, portability, etc., and is widely used in the fields of smoking cessation assistance and metabolic regulation.

[0003] The oral nicotine product mainly contains a nicotine active substance and a filler (such as microcrystalline cellulose). In addition, the oral nicotine product usually also contains a flavor for improving taste and attractiveness. In the current preparation method of the oral nicotine product, usually the flavor and the nicotine active substance, etc. are mixed with the filler together. For the prepared oral nicotine product, the aroma attenuation of the flavor is relatively serious, and then the nicotine odor will be relatively obvious, affecting the taste and user experience.

[0004] Therefore, there is an urgent need for a product and / or method that can reduce the aroma attenuation of the flavor and improve the aroma persistence. Summary of the Invention

[0005] The present application provides a porous carrier, an oral product and a preparation method thereof, which are used to solve the problem of obvious aroma attenuation of the existing flavor.

[0006] The present application discloses a porous carrier, and the porous carrier is particles made of a material including microcrystalline cellulose, porous silica and copovidone.

[0007] In one implementation manner of the present application, the particle size of the porous carrier is 30μm - 70μm.

[0008] In one implementation manner of the present application, for the porous carrier, by mass, it includes 50.3 - 62.3 parts of the microcrystalline cellulose, 31.2 - 41.2 parts of the porous silica, and 6.5 - 8.5 parts of the copovidone.

[0009] The present application also discloses an oral product, which includes a flavor and the porous carrier as described in any one of the above, and the porous carrier is used to adsorb the flavor.

[0010] In one implementation manner of the present application, the oral product includes a filler and an active substance, and the active substance is coated on the outer layers of the filler and the porous carrier.

[0011] In one implementation of the present application, the oral product further includes at least one of an adhesive, a sweetening agent, and a pH regulator.

[0012] In one implementation of the present application, the filler includes at least one of microcrystalline cellulose, xylitol, sorbitol, mannitol, lactitol, isomaltulose, and erythritol; and / or, the active substance includes at least one of nicotine and nicotine derivatives; and / or, the adhesive includes at least one of sodium alginate, hypromellose, and carboxymethyl cellulose; and / or, the sweetening agent includes at least one of xylitol, sorbitol, mannitol, eglicol, lactitol, maltitol, isomaltulose, hydrogenated starch hydrolysate, erythritol, maltotriitol, aspartame, acesulfame potassium, sodium saccharin, sucralose, neotame, sodium cyclamate, alitame, stevioside, arabitol, and mogroside; and / or, the pH regulator includes at least one of sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate, magnesium carbonate, and citric acid.

[0013] In one implementation of the present application, the oral product, by mass, includes: 0.5 to 20 parts of the essence, 10 to 40 parts of the porous carrier, 0.5 to 10 parts of the active substance, 10 to 50 parts of the filler, 0 to 10 parts of the adhesive, 0.1 to 2 parts of the sweetening agent, and 0.05 to 0.5 parts of the pH regulator.

[0014] In one implementation of the present application, the oral product further includes a permeable bag that is permeable to saliva, and both the essence and the porous carrier are encapsulated in the permeable bag.

[0015] The present application also discloses a method for preparing an oral product, including: mixing an essence and the porous carrier according to any one of the above, and adsorbing the essence on the porous carrier to obtain essence particles; and mixing the essence particles, the active substance, and the filler to prepare the oral product.

[0016] The beneficial effects of the present application are as follows:

[0017] The porous carrier of the present application is prepared from three materials including microcrystalline cellulose, porous silica, and copovidone. Through different adsorption mechanisms, it can significantly increase the adsorption capacity and stability of the essence, and thus help reduce the aroma attenuation of the essence and improve the aroma persistence. Description of the Drawings

[0018] Figure 1 is a scanning electron microscope image of the porous carrier. Detailed Embodiments

[0019] The present invention will be further described in detail below in conjunction with the accompanying drawings through specific embodiments. In the following embodiments, many detailed descriptions are provided to enable a better understanding of the present application. However, those skilled in the art can easily recognize that some of the features can be omitted in different situations, or can be replaced by other materials or methods. In some cases, some operations related to the present application are not shown or described in the specification, which is to avoid the core part of the present application being overwhelmed by excessive descriptions. For those skilled in the art, it is not necessary to describe these related operations in detail, and they can fully understand the related operations based on the descriptions in the specification and the general technical knowledge in the art.

[0020] In addition, the features, operations or characteristics described in the specification can be combined in any appropriate manner to form various embodiments. At the same time, the steps or actions in the method description can also be reordered or adjusted in an obvious manner by those skilled in the art. Therefore, the various sequences in the specification and the drawings are only for clearly describing a certain embodiment and do not mean that they are the necessary sequences, unless it is stated otherwise that a certain sequence must be followed.

[0021] The serial numbers assigned to the components herein, such as "first", "second", etc., are only used to distinguish the described objects and do not have any sequential or technical meanings.

[0022] Oral nicotine products mainly contain nicotine active substances and fillers (such as microcrystalline cellulose). In addition, oral nicotine products usually also contain flavors for improving taste and attractiveness. In the current preparation methods of oral nicotine products, flavors and nicotine active substances are usually mixed together with fillers. For the prepared oral nicotine products, the aroma attenuation of the flavors is relatively severe, which in turn leads to a more obvious nicotine odor, affecting the taste and user experience. For example, in current wet nicotine pouch products, liquid flavors are directly sprayed onto microcrystalline cellulose, and the aroma attenuation of the flavors is relatively severe. As the aroma attenuates, the nicotine odor becomes more obvious. To solve the problem of obvious odor, more flavors are usually added. However, too much flavor will result in an overly strong smell, poor user experience, and it will also cause the products to easily agglomerate during the wet granulation process, and the powder flowability of oral nicotine products is poor.

[0023] In view of this, the present application creatively provides a porous carrier, a preparation method thereof, an oral product and a preparation method thereof. In the present application, the components of the porous carrier include microcrystalline cellulose, porous silica and copovidone, and the porous carrier particles are prepared by spray drying technology. By first adsorbing flavorings with the porous carrier of the present application and then mixing them with other added components, an oral product can be prepared, which can reduce the attenuation of aroma, enhance the persistence of aroma, effectively mask the odor of nicotine, and improve the user experience. In addition, by using the porous carrier of the present application, the powder fluidity of the wet granulation of the oral product can be improved, and the product performance and product consistency can be enhanced.

[0024] Most oral products contain flavorings, which can mask the bitter taste of nicotine and make the product more acceptable to consumers. These flavorings can be natural or synthetic and are used to provide a variety of flavor options. In a specific embodiment, the flavorings can include natural flavorings and synthetic flavorings. Natural flavorings can include: ① Plant extracts: Flavors extracted from natural plants, such as menthol (extracted from mint leaves), citrus flavorings (extracted from the peels of fruits such as lemons and oranges); ② Essential oils: For example, tea tree oil, lavender oil, etc., which are commonly used to provide a fresh or relaxing effect. Synthetic flavorings can include: ① Chemically synthesized flavorings: Flavors synthesized by chemical methods, such as artificially synthesized menthol, isoamyl acetate (banana flavor), benzaldehyde (almond flavor), etc.; ② Blended flavorings: Blended from a variety of natural and synthetic flavorings to achieve a specific flavor effect.

[0025] In a specific embodiment, the flavorings are edible flavorings.

[0026] In a specific embodiment, the flavorings can include at least one of bergamot flavoring, eucalyptus flavoring, citrus flavoring, lemon flavoring, peppermint flavoring, mint flavoring, menthol, licorice flavoring, wintergreen flavoring, tobacco flavoring, coffee flavoring, vanilla flavoring, lime flavoring, apple flavoring, peach flavoring, mango flavoring, cherry flavoring, blueberry flavoring, strawberry flavoring, cola flavoring, cinnamon flavoring, vanillin flavoring and watermelon flavoring. The flavorings can also be other kinds of edible flavorings, which will not be elaborated herein one by one.

[0027] In a specific embodiment, a porous carrier is provided for adsorbing flavorings.

[0028] In a specific embodiment, the porous carrier can be made of a material including microcrystalline cellulose, porous silica and copovidone.

[0029] It should be noted that microcrystalline cellulose has a large specific surface area and porous structure, which can provide a large number of adsorption sites for flavor molecules. In addition, a large number of hydroxyl groups are contained in the microcrystalline cellulose molecules, and these hydroxyl groups can interact with flavor molecules through hydrogen bonds; porous silica has an extremely large specific surface area, providing a large number of adsorption sites. In addition, a large number of silanol groups are contained on the surface of porous silica, which can interact with flavor molecules through hydrogen bonds; copovidone contains carbonyl groups and nitrogen atoms (N), and these functional groups can bind to flavor molecules through van der Waals forces, hydrogen bonds and / or dipole-dipole interactions. Copovidone has good water solubility and film-forming properties, which helps to evenly distribute flavor molecules. Through different adsorption mechanisms, the three materials can significantly increase the adsorption capacity and stability of flavors. For example, microcrystalline cellulose and porous silica can provide a large number of adsorption sites, while copovidone can form a uniform covering layer on these sites to further enhance the fixation effect of flavors. In addition, there is a synergistic effect among the three. Porous silica can be embedded on the surface of microcrystalline cellulose. Both microcrystalline cellulose and porous silica have the function of repairing flavors. The adsorption of porous silica is stronger, and porous silica can greatly enhance the fluidity of microcrystalline cellulose.

[0030] In a specific embodiment, the porous carrier is granular. That is, the porous carrier can be a particle made of a material including microcrystalline cellulose, porous silica and copovidone.

[0031] It should be noted that the porous carrier particles prepared by using three materials including microcrystalline cellulose, porous silica and copovidone can be used to adsorb flavors. Compared with separately adding microcrystalline cellulose, porous silica and copovidone powders as porous carriers to adsorb flavors, the adsorption effect on flavors is better, and there is a synergistic effect among microcrystalline cellulose, porous silica and copovidone. Moreover, using the porous carrier particles can improve the fluidity of the powder of the buccal products, reduce the agglomeration phenomenon, and have less impact on the product performance of the buccal products. Specifically, the density of porous silica alone is low, and there will be a phenomenon of flying powder during the preparation of the buccal products. Moreover, the porous silica powder is prone to agglomeration when encountering water, which may lead to unqualified product appearance, product consistency, etc. of the nicotine buccal products.

[0032] In a specific embodiment, the particle size of the porous carrier is 30 μm to 70 μm. For example, the particle size of the porous carrier can be 30 μm, 35 μm, 40 μm, 45 μm, 50 μm, 55 μm, 60 μm, 65 μm or 70 μm.

[0033] It should be noted that the particle size in this application refers to the equivalent diameter, which can be the volume equivalent diameter or the surface area equivalent diameter.

[0034] In a specific embodiment, the microcrystalline cellulose in the porous carrier may include one or more types.

[0035] In a specific embodiment, the average particle size of the microcrystalline cellulose may be 30 to 60 μm. For example, the average particle size of the microcrystalline cellulose may be 30 μm, 35 μm, 40 μm, 45 μm, 50 μm, 55 μm, or 60 μm.

[0036] In a specific embodiment, the particle size D50 of the microcrystalline cellulose may be 40 to 60 μm. For example, the particle size D50 of the microcrystalline cellulose may be 40 μm, 45 μm, 50 μm, 55 μm, or 60 μm.

[0037] In a specific embodiment, the porous silica may include at least one of microporous silica, mesoporous silica, and meso-microporous composite silica. Among them, the pore diameter of the microporous silica is less than 2 nanometers, and it has an extremely high specific surface area (up to 1000 m 2 / g or more) and excellent adsorption capacity. The pore diameter range of the mesoporous silica is 2 to 50 nanometers, and it has both a relatively high specific surface area and a relatively large pore volume, facilitating the entry and diffusion of molecules. The microporous silica may include zeolite molecular sieves, including but not limited to models such as Silicalite-1 and Silicalite-2. The mesoporous silica may include but not limited to the MCM series (such as MCM-41, MCM-48), the SBA series (such as SBA-15). The meso-microporous composite silica includes but not limited to the complex of microporous zeolite and mesoporous silica (such as Hierarchical Zeolites), and the microporous-mesoporous hybrid material (such as the MSU series).

[0038] In a specific embodiment, the porous silica may have an ordered porous structure. For example, it may be a hexagonal mesoporous structure, a bicontinuous cubic mesoporous structure, a ten-membered ring pore structure, etc.

[0039] In a specific embodiment, the porous silica may have a disordered porous structure. For example, it may be an irregular network pore structure.

[0040] In a specific embodiment, the average particle size of the porous silica may be less than 5 μm. For example, the average particle size of the porous silica may be 1 μm, 2 μm, 3 μm, 4 μm, or 5 μm. Thus, it can have better fluidity and more uniform adsorption.

[0041] In a specific embodiment, the molecular weight of copolyvidone can be 45,000 to 70,000 Da (weight average molecular weight). Copolyvidone, also known as polyvidone copolymer or PVP-VA, is a copolymer formed by free radical polymerization of vinylpyrrolidone (VP) and vinyl acetate (VA).

[0042] In a specific embodiment, the average particle size of the copovidone may be 30 μm to 60 μm. For example, the average particle size of the copovidone may be 30 μm, 35 μm, 40 μm, 45 μm, 50 μm, 55 μm or 60 μm.

[0043] In a specific embodiment, the particle size D90 of the copovidone may be ≤50 μm.

[0044] In a specific embodiment, the porous carrier may include 50.3 to 62.3 parts of microcrystalline cellulose by weight, for example, 50.3, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, or 62.3 parts of microcrystalline cellulose by weight.

[0045] In a specific embodiment, the porous support may include 31.2 to 41.2 parts by mass of porous silica, for example, 31.2, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, or 41.2 parts by mass of porous silica.

[0046] In a specific embodiment, the porous carrier can include 6.5 to 8.5 parts of copolyvidone by weight. For example, it can include 6.5, 6.6, 6.7, 6.8, 6.9, 7, 7.1, 7.2, 7.3, 7.4, 7.5, 7.6, 7.7, 7.8, 7.9, 8, 8.1, 8.2, 8.3, 8.4 or 8.5 parts of copolyvidone.

[0047] In a specific embodiment, the porous carrier may be in the shape of at least one of sphere, quasi-sphere or block.

[0048] In a specific embodiment, the particle size distribution of the porous carrier may range from 30 μm to 70 μm. For example, the particle size of the porous carrier may be 30 μm, 35 μm, 40 μm, 45 μm, 50 μm, 55 μm, 60 μm, 65 μm or 70 μm.

[0049] In a specific embodiment, the water content of the porous carrier may be no more than 6% (mass fraction). For example, the water content of the porous carrier may be 1%, 2%, 3%, 4%, 5% or 6%.

[0050] In a specific embodiment, the pH of the porous carrier can be 4.0 to 6.0. For example, the pH of the porous carrier can be 4.0, 4.5, 5, 5.5, or 6.0.

[0051] In a specific embodiment, the bulk density of the porous carrier can be 0.22 g / mL to 0.34 g / mL. For example, the bulk density of the porous carrier can be 0.22 g / mL, 0.25 g / mL, 0.3 g / mL, or 0.34 g / mL.

[0052] In a specific embodiment, a method for preparing a porous carrier is provided, including: a liquid preparation step and a granulation step.

[0053] In a specific embodiment, the liquid preparation step may include: making microcrystalline cellulose, porous silica, copovidone, and a solvent into a solution or suspension.

[0054] In a specific embodiment, the solvent can be water or ethanol.

[0055] In a specific embodiment, the solid content of the solution or suspension is 10% to 20%. For example, the solid content can be 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, or 20%.

[0056] In a specific embodiment, the granulation step may include: making the solution or suspension into granular porous carriers through a spray drying process.

[0057] In a specific embodiment, the parameters of the spray drying process may include: the compressed air pressure is 0.2 MPa to 0.7 MPa.

[0058] In a specific embodiment, the parameters of the spray drying process may include: the gas-liquid volume ratio is 0.5 to 2.

[0059] In a specific embodiment, the parameters of the spray drying process may include: the inlet air temperature can be 150 °C to 250 °C.

[0060] In a specific embodiment, the parameters of the spray drying process may include: the outlet air temperature can be 80 °C to 120 °C. It should be noted that the outlet air temperature reflects the drying end point and affects the product moisture.

[0061] In a specific embodiment, the parameters of the spray drying process may include: the hot air flow rate can be 0.5 m 3 / s to 5 m 3 / s. It should be noted that it can match the production capacity.

[0062] In a specific embodiment, the parameters of the spray drying process may include: the drying time is 10 seconds to 30 seconds. That is, the residence time of the droplets is 10 seconds to 30 seconds.

[0063] In a specific embodiment, after the granulation step, a drying step is further included.

[0064] In a specific embodiment, the drying step may include using a vacuum drying method. The degree of vacuum can be -0.06 MPa to 0.08 MPa. The drying temperature can be 60°C to 80°C.

[0065] In a specific embodiment, an oral-containing product is provided. The oral-containing product is a product containing active substances (nicotine and / or its derivatives), usually placed in the oral cavity in the form of powder, granules, film tablets, tablets, chewing gum, etc. for the oral mucosa to absorb the active substances. The product forms include nicotine pouches, nicotine orodispersible films, nicotine lozenges, nicotine chewing gum, etc. In this embodiment, the oral-containing product is a nicotine pouch product containing granular substances.

[0066] In a specific embodiment, the oral-containing product may contain the above-mentioned flavor and porous carrier. In other words, an application of the porous carrier in the oral-containing product is provided. It should be noted that when using the porous carrier in the oral-containing product, microcrystalline cellulose in the porous carrier can provide structural support and volume filling, making the product have a good texture. Porous silica can be used as a flow aid to prevent powder caking and improve the fluidity of the product. Copovidone can make the flavor molecules evenly distributed in the product through film-forming, prolonging the release time. Using the porous carrier in the oral-containing product can improve the powder fluidity of the oral-containing product, and the powder is not easily agglomerated.

[0067] In some embodiments, in addition to adsorbing the flavor, the porous carrier in the oral-containing product may also adsorb other oily substances or substances soluble in oily solvents, such as active substances.

[0068] In a specific embodiment, the oral-containing product, by mass, may include 0.5 parts to 20 parts of flavor. For example, it may include 0.5, 1, 3, 5, 8, 10, 15, 18 or 20 parts of flavor.

[0069] In a specific embodiment, the oral-containing product, by mass, may include 5 parts to 90 parts of the porous carrier. For example, it may include 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85 or 90 parts of the porous carrier. Further, the oral-containing product, by mass, includes 10 to 40 parts of the porous carrier.

[0070] In a specific embodiment, the oral product contains 0.5 to 20 parts by mass of an active substance. The active substance may include at least one of nicotine and nicotine derivatives for providing a sense of satisfaction. For example, it may include 0.5, 1, 3, 5, 8, 10, 15, 18, or 20 parts of the active substance.

[0071] Among them, nicotine includes natural nicotine and synthetic nicotine. Nicotine derivatives include one or several of nicotine salts, nicotine in a matrix such as a sugar matrix or an organometallic complex, nicotine-resin combinations, nicotine inclusion complexes, and non-covalently bound nicotine. Among them, non-covalently bound nicotine includes nicotine lactate, nicotine malate, nicotine salicylate, nicotine cyclodextrin inclusion complex, nicotine hydrochloride, nicotine dihydrochloride, nicotine tartrate, nicotine tartrate dihydrate, nicotine sulfate, nicotine zinc chloride, nicotine benzoate, etc. Nicotine derivatives also include substituted nicotine, such as one or more mixtures of hexamethyl nicotine, hexamethyl nicotine lactate, hexamethyl nicotine malate, hexamethyl nicotine salicylate, hexamethyl nicotine cyclodextrin inclusion complex, hexamethyl nicotine hydrochloride, hexamethyl nicotine dihydrochloride, hexamethyl nicotine tartrate, hexamethyl nicotine tartrate dihydrate, hexamethyl nicotine sulfate, hexamethyl nicotine zinc chloride, hexamethyl nicotine benzoate.

[0072] In a specific embodiment, the oral product may include a filler. The filler is mainly used to adsorb nicotine active substances and other excipients such as sweeteners.

[0073] In a specific embodiment, the active substance may be coated on the outer layer of the filler and the porous carrier.

[0074] In a specific embodiment, the filler may include microcrystalline cellulose. Microcrystalline cellulose may include types such as microcrystalline cellulose 101, 102, 112, 301, 200, etc.

[0075] In a specific embodiment, the filler may include sugar alcohols. The sugar alcohols may include at least one of xylitol, sorbitol, mannitol, lactitol, isomaltitol, and erythritol.

[0076] In a specific embodiment, the oral product, by mass, may include 5 to 90 parts of the filler. For example, it may include 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, or 90 parts of the filler.

[0077] In a specific embodiment, the oral product may include an adhesive.

[0078] In a specific embodiment, the binder may include at least one of the following: sodium alginate, hydroxypropyl methylcellulose, and carboxymethyl cellulose.

[0079] In a specific embodiment, the oral product, by mass parts, may include 0 parts to 10 parts of the binder. For example, it may include 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 parts of the binder.

[0080] In a specific embodiment, the oral product may include a sweetening agent.

[0081] In a specific embodiment, the sweetening agent may include at least one of xylitol, sorbitol, mannitol, erythritol, lactitol, maltitol, isomaltulose, hydrogenated starch hydrolysate, erythritol, maltotriitol, aspartame, acesulfame potassium, sodium saccharin, sucralose, neotame, sodium cyclamate, alitame, stevioside, arabitol, and mogroside. The sweetening agent may also be selected from other edible-grade substances, which will not be elaborated herein one by one.

[0082] In a specific embodiment, the oral product, by mass parts, may include 0.1 parts to 2 parts of the sweetening agent. For example, it may include 0.1, 0.5, 1, 1.5, or 2 parts of the sweetening agent.

[0083] In a specific embodiment, the oral product may include a pH regulator. The pH regulator can be used to adjust the acidity and alkalinity of the nicotine film. The pH regulator can be acidic or basic, such as sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate, or magnesium carbonate. In some embodiments, the pH regulator is acidic, such as citric acid. In some embodiments, the pH regulator is basic. The basic pH regulator has the following advantages: The basic pH condition helps nicotine convert from its salt form to the free base form, thereby improving the bioavailability of nicotine. In the oral environment, nicotine in the free base form is more easily absorbed by the oral mucosa into the blood circulation; adjusting the pH can improve the taste of the oral nicotine product, reduce irritation or discomfort, and the basic pH can neutralize some acidic components, making the product milder; by adjusting the pH value, the stability of the oral product can be improved to prevent component decomposition or deterioration; an appropriate pH value can help inhibit the growth of microorganisms, thereby extending the shelf life of the product.

[0084] In a specific embodiment, the oral product, by mass parts, may include 0.05 parts to 0.5 parts of the pH regulator. For example, it may include 0.05, 0.1, 0.2, 0.3, 0.4, or 0.5 parts of the pH regulator.

[0085] In a specific embodiment, the oral product may include a cooling agent for improving the taste.

[0086] In a specific embodiment, the cooling agent may include at least one of menthol, menthol derivatives, WS-3, and WS-23.

[0087] In a specific embodiment, the oral-containing product, by mass fraction, may include 0.02 parts to 0.1 parts of the cooling agent. For example, it may include 0.02, 0.05, 0.08, and 0.1 parts of the cooling agent.

[0088] In a specific embodiment, the oral-containing product may further include a permeable bag. The permeable bag is permeable to saliva.

[0089] In a specific embodiment, at least one of the active substance, filler, flavor, porous carrier, binder, sweetener, pH regulator, and cooling agent is encapsulated in the permeable bag.

[0090] In a specific embodiment, a method for preparing an oral-containing product is provided, including: mixing the flavor and the porous carrier to obtain flavor particles (the flavor is adsorbed on the porous carrier); mixing the flavor particles, the active substance, and the filler to prepare the oral-containing product.

[0091] In a specific embodiment, the method for preparing the oral-containing product may specifically include: a flavor adsorption step, a mixing step, and a liquid spraying step.

[0092] In a specific embodiment, the flavor adsorption step includes: using a liquid flavor or dissolving a solid flavor in a solvent to obtain a flavor solution, mixing the liquid flavor or the flavor solution with the above-mentioned porous carrier, and enabling the flavor to be adsorbed on the porous carrier to obtain the porous carrier adsorbed with the flavor, that is, flavor particles.

[0093] In a specific embodiment, the mixing step includes: mixing the porous carrier adsorbed with the flavor and the filler to obtain a mixed material.

[0094] In a specific embodiment, the liquid spraying step includes: first adding nicotine, sweetener, pH regulator, and binder to a solvent to make a solution or suspension, spraying the solution or suspension onto the above-mentioned mixed material, and stirring to obtain the oral-containing product.

[0095] It should be noted that in the present application, by first adsorbing the flavor with the porous carrier and then mixing it with other materials to prepare the oral-containing preparation, the attenuation of the aroma can be prolonged, and the odor of nicotine can be effectively masked.

[0096] In a specific embodiment, after the liquid spraying step, a sieving step is further included. The particles prepared by liquid spraying are filtered through a 20-mesh sieve.

[0097] The present application will be further described in detail below through specific experimental procedures and experimental data examples. The following examples are only for further illustration of the present application and should not be construed as limitations on the present application. In this example, unless otherwise specified, the reagents and instruments used are all commercially available, and the experimental operations are carried out in accordance with the product instructions and conventional experimental specifications.

[0098] Example 1:

[0099] (1) Preparation of porous carrier

[0100] Material preparation: Prepare porous silica, copovidone, and microcrystalline cellulose according to the mass ratio of porous silica: copovidone: microcrystalline cellulose = 35:7:58. Among them, the product model of porous silica is Sylysia 350FCP, the model of copovidone is VA64, and the model of microcrystalline cellulose is MCC101.

[0101] Preparation of suspension: Add the above-prepared materials to purified water and stir to prepare a suspension with a solid content of 15%.

[0102] Spray drying: Use the spray drying process to prepare powder. The parameters are as follows: the compressed air pressure is 0.5 MPa, the gas-liquid volume ratio is 1, the inlet air temperature is 160 °C, the outlet air temperature is 100 °C, the hot air flow rate is 3 m 3 / s, and the drying time is 20 seconds.

[0103] Vacuum drying: Place the sample after spray drying on a tray and dry it in a vacuum dryer. The parameters are as follows: the temperature is 70 °C and the vacuum degree is -0.08 Mpa. A porous carrier is obtained.

[0104] Figure 1 is the scanning electron microscope (SEM) image of the porous carrier. As Figure 1 shown, the shape of the porous carrier is spherical-like and blocky, and the particle size is about 50 μm.

[0105] (2) Preparation of nicotine pouch (i.e., oral product):

[0106] Prepare materials according to the following table:

[0107]

[0108]

[0109] Process steps:

[0110] ① Adsorb essence: Drop the liquid essence into the porous carrier while dropping and stirring. The stirring speed is 150 rpm and the stirring time is 5 min.

[0111] ② Mixing: Add microcrystalline cellulose 102 and the porous carrier adsorbed with flavor prepared in step ① into a wet granulation pot, start stirring, stirring rate: 150 rpm; cutter rate: 1500 rpm; mixing time: 2 min.

[0112] ③ Dissolving: Dissolve nicotine, binder and sweetener with purified water to make a solution.

[0113] ④ Spray-liquid mixing: Add the solution prepared in step ③ into the mixed materials in step ② with a spray gun, stir for 30 seconds after spraying, stirring rate: 150 rpm; cutter rate: 1500 rpm.

[0114] ⑤ Sieving: Discharge the materials prepared in step ④, sieve through a 20-mesh sieve to obtain the buccal products.

[0115] ⑥ Bagging: According to the filling amount of 600 mg of buccal products per bag, put the prepared buccal products into fiber bags and seal them.

[0116] Example 2: The difference from Example 1 is that the dosage of the porous carrier is 30%, and the dosage of the filler microcrystalline cellulose 102 is 22.2%. The rest is the same as Example 1.

[0117] Example 3: The difference from Example 1 is that the dosage of the porous carrier is 20%, and the dosage of the filler microcrystalline cellulose 102 is 32.2%. The rest is the same as Example 1.

[0118] Example 4: The difference from Example 1 is that the dosage of the porous carrier is 10%, and the dosage of the filler microcrystalline cellulose 102 is 42.2%. The rest is the same as Example 1.

[0119] Comparative Example 1: The difference from Example 1 is that the dosage of the porous carrier is 0, and the dosage of the filler microcrystalline cellulose 102 is 52.2%. The rest is the same as Example 1.

[0120] Comparative Example 2: The difference from Example 1 is that the porous carrier does not contain silica, that is, the porous carrier contains copovidone and microcrystalline cellulose with a mass ratio of 7:58. The rest is the same as Example 1.

[0121] Comparative Example 3: The difference from Example 1 is that the porous carrier does not contain copovidone, that is, the porous carrier contains silica and microcrystalline cellulose with a mass ratio of 35:58. The rest is the same as Example 1.

[0122] Comparative Example 4: The difference from Example 1 is that the porous carrier does not contain microcrystalline cellulose, that is, the porous carrier contains silica and copovidone with a mass ratio of 35:7. The rest is the same as Example 1.

[0123] Taste evaluation results:

[0124]

[0125]

[0126] Scoring Instructions: In the above table, a scoring system is adopted for the taste test. 5 points: very satisfied; 4 points: satisfied; 3 points: average; 2 points: dissatisfied; 1 point: extremely poor; the scoring gradient is 0.5 points.

[0127] As can be seen from the above table, when 10 - 40% of the porous carrier is added, the aroma attenuation is greatly improved compared to using pure microcrystalline cellulose as the filler for the buccal product (i.e., without the porous carrier). As the content of the porous carrier increases, the effect of inhibiting aroma attenuation is better, and the effect of masking the nicotine odor is also better. The effects of the porous carrier at dosages of 30% and 40% are equivalent. Among the three components of the porous carrier, silica, copovidone, and microcrystalline cellulose, the lack of any one of them will also lead to faster aroma attenuation and difficulty in masking the nicotine odor.

[0128] Test results of other properties:

[0129]

[0130] In the above table, the filling quantity differences of 20 bags of samples were measured for each example and comparative example. The results show that as the dosage of the porous carrier increases, the relative standard deviation (RSD) of the filling quantity difference decreases, indicating that the use of the porous carrier can improve the powder fluidity of the buccal product, and the powder is less likely to agglomerate.

[0131] The above content is a further detailed description of the present application in combination with specific embodiments, and it cannot be determined that the specific implementation of the present application is only limited to these descriptions. For those of ordinary skill in the technical field to which the present application belongs, without departing from the concept of the present application, several simple deductions or substitutions can still be made.

Claims

1. A porous carrier, characterized in that, The porous carrier is particles made of a material including microcrystalline cellulose, porous silica, and copovidone.

2. The porous carrier according to claim 1, characterized in that, The particle size of the porous carrier is 30 μm to 70 μm.

3. The porous carrier according to claim 1 or 2, characterized in that, The porous carrier, by mass parts, includes 50.3 to 62.3 parts of the microcrystalline cellulose, 31.2 to 41.2 parts of the porous silica, and 6.5 to 8.5 parts of the copovidone.

4. An oral product, characterized in that, It includes a fragrance and the porous carrier according to any one of claims 1 to 3, and the porous carrier is used for adsorbing the fragrance.

5. The oral product according to claim 4, wherein The buccal product includes a filler and an active substance, and the active substance is coated on the outer layers of the filler and the porous carrier.

6. The oral product according to claim 5, wherein, The buccal product further includes at least one of an adhesive, a sweetener, and a pH regulator.

7. The buccal agent according to claim 6, wherein The filler includes at least one of microcrystalline cellulose, xylitol, sorbitol, mannitol, lactitol, isomalt, and erythritol; and / or, The active substance includes at least one of nicotine and nicotine derivatives; and / or, The adhesive includes at least one of sodium alginate, hypromellose, and carboxymethyl cellulose; and / or, The sweetener includes at least one of xylitol, sorbitol, mannitol, euglycol, lactitol, maltitol, isomalt, hydrogenated starch hydrolysate, erythritol, maltotriitol, aspartame, acesulfame potassium, sodium saccharin, sucralose, neotame, sodium cyclamate, alitame, stevioside, arabitol, and mogroside; and / or, The pH regulator includes at least one of sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate, magnesium carbonate, and citric acid.

8. The oral product according to claim 6, characterized in that, The buccal product, by mass parts, includes: 0.5 to 20 parts of the fragrance, 10 to 40 parts of the porous carrier, 0.5 to 10 parts of the active substance, 10 to 50 parts of the filler, 0 to 10 parts of the adhesive, 0.1 to 2 parts of the sweetener, and 0.05 to 0.5 parts of the pH regulator.

9. The oral composition according to any one of claims 4 to 8, characterized in that, The buccal product further includes a permeable bag that can permeate saliva, and both the fragrance and the porous carrier are encapsulated in the permeable bag.

10. A method for preparing an orally-held product, characterized in that, It includes: Mixing the fragrance and the porous carrier according to any one of claims 1 to 3, and adsorbing the fragrance on the porous carrier to obtain fragrance particles; Mixing the fragrance particles, the active substance, and the filler to prepare the buccal product.

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