Sterile filling and plugging device and method for preparing animal vaccines

Abstract

The invention discloses a sterile filling and plugging device and method for preparing animal vaccines, and relates to the technical field of vaccine production. The device comprises a bottle conveying device, the bottle conveying device is composed of a conveying belt, a transmission mechanism and a bottle support and used for bearing and conveying vaccine bottles, an automatic filling device and an automatic plugging device are arranged on the two sides of the bottle conveying device respectively, a bottle plug arranging mechanism is arranged above the automatic plugging device, and a bottle plug conveying mechanism is arranged at the top of the automatic plugging device. A bottle plug disinfection assembly is arranged on the outer side of the bottle plug conveying mechanism; by arranging the automatic filling device and the automatic plugging device, the automatic plugging device is driven to perform bottle plug installation on the filled penicillin bottle in the resetting process after the penicillin bottle is filled with animal vaccines through the automatic filling device, and the effect of installing the bottle plug while filling is achieved through the operation; the production efficiency is effectively improved, meanwhile, the possibility that vaccines are polluted in the penicillin bottles is reduced, and the quality and safety of the vaccines are improved.

Description

Technical Field

[0001] The present invention relates to the technical field of vaccine production, and specifically to a sterile filling and plugging device and method for preparing animal vaccines. Background Art

[0002] Animal vaccines are biological products used for preventing and controlling animal infectious diseases and other diseases. Their production process has extremely high requirements for a sterile environment and process specifications. During the production process of animal vaccines, the prepared animal vaccines need to be filled into vials and then plugged. In the traditional production process, the filling and plugging links of animal vaccines are often set at different workstations, and rely on a conveying device to transfer the vials. Although the production workshop generally adopts a sterile design, there is still an inevitable risk of bacterial contamination during the transfer process, which will affect the quality stability of the vaccine. In addition, even if the stoppers have been disinfected and sterilized in the early stage, they may still be re-contaminated due to contact with the external environment or equipment components during subsequent sorting and conveying, posing a potential threat to the safety of the vaccine. To solve the above problems, the inventor proposes a sterile filling and plugging device and method for preparing animal vaccines to solve the above problems. Summary of the Invention

[0003] In order to solve the problems of pollution risk caused during the transfer process of the vaccine at the filling and plugging workstations and avoid secondary contamination of the stoppers; the purpose of the present invention is to provide a sterile filling and plugging device and method for preparing animal vaccines.

[0004] To solve the above technical problems, the present invention adopts the following technical solutions: a sterile filling and plugging device for preparing animal vaccines, including a bottle conveying device, which is composed of a conveyor belt, a transmission mechanism, and a bottle holder, and is used to carry and transport vaccine bottles. On both sides of the bottle conveying device, there are respectively an automatic filling device for filling the vaccine into the vials and an automatic plugging device for sealing the vial mouths. Above the automatic plugging device, there is a stopper sorting mechanism for sorting the messy stoppers into a neat queue. On the top of the automatic plugging device, there is a stopper conveying mechanism that cooperates with the stopper sorting mechanism. Outside the stopper conveying mechanism, there is a stopper disinfection assembly; The automatic filling device includes a base and a first fixed shaft. The base is fixedly installed at the top of the corresponding bracket. The first fixed shaft is horizontally and fixedly installed in the base. Two symmetrically distributed turning plates are rotatably sleeved on the outer wall of the first fixed shaft. Above the two turning plates, there is a rotating shaft rotatably arranged. A fixed wheel is fixedly sleeved on the outer wall of the first fixed shaft. A moving wheel is fixedly sleeved on the outer wall of the rotating shaft. And a toothed belt is sleeved on the outer walls of the fixed wheel and the moving wheel. In the middle of the outer wall of the rotating shaft, there is a filling platform fixedly sleeved; The automatic plugging device includes a plugging table. The plugging table is fixedly installed at the top of the corresponding bracket. In the middle of the plugging table, there is a second fixed shaft horizontally and fixedly arranged. A capping head is rotatably sleeved on the outer wall of the second fixed shaft.

[0005] Preferably, a driving shaft is provided for horizontal rotation below the base, a connecting shaft is fixedly provided in the middle between the two flip plates, and one end of the connecting shaft passes through one side of the flip plate, a push rod is fixedly provided at the end of the driving shaft, a driven rod is rotatably provided at the other end of the push rod, and the top end of the driven rod is rotatably connected to the connecting shaft, a driven shaft is rotatably provided just below the base, a one-way bearing is provided at a fixed sleeve on the outer wall of the driven shaft, a rotating gear is provided at the fixed sleeve on the outer wall of the one-way bearing, a half gear is fixed at the end of the driving shaft, and the half gear is meshed with the rotating gear, an electric cylinder is rotatably provided at the top of the fixed bracket corresponding to the automatic filling device, and the driving end of the electric cylinder is rotatably connected to the middle of the push rod, four equidistantly distributed filling heads are provided on the filling platform, and the filling heads are connected to the liquid storage tank through a metering pump.

[0006] Preferably, the outer wall of the plugging platform is provided with an active lifting frame for sliding, and transverse grooves are opened on both sides of the active lifting frame, and arc grooves are provided at both sides of the plugging platform for cooperating with the transverse grooves. Guide shafts are fixedly provided at both sides of the bottom of the capping head, and the guide shafts slide in the transverse grooves and the arc grooves. A No. 1 transmission shaft is rotated in the middle of the fixed bracket on one side of the bottle cork sorting mechanism, and a rotating rod is fixedly provided at the end of the No. 1 transmission shaft. The end of the rotating rod slides in the active lifting frame, and four pneumatic suction cups corresponding to the filling head for fixing the bottle cork are provided on the top of the capping head, and the pneumatic suction cup is connected to the external air source through an air guide pipe. A No. 3 transmission shaft is provided for horizontal rotation at the bottom end of the plugging platform, and the No. 3 transmission shaft is connected to the driven shaft through a synchronous wheel transmission group. A No. 2 transmission shaft is provided for longitudinal rotation at the bottom end of the plugging platform, and the No. 2 transmission shaft is meshed with the No. 3 transmission shaft through a bevel gear, and the No. 2 transmission shaft is connected to the No. 1 transmission shaft through a pulley transmission group, and the active lifting frame is slidably connected to the outer wall of the plugging platform through a guide rail.

[0007] Preferably, the bottle cork conveying mechanism includes a vertical plate, which is fixedly installed on the top of the corking platform. Four conveying tracks corresponding to the pneumatic suction cups for conveying bottle corks are fixed on the outside of the vertical plate. The top of the conveying track corresponds to the discharge end of the bottle cork sorting mechanism. A rotating shaft is provided on one side of the bottom end of the conveying track. A baffle is fixed on the bottom end of the rotating shaft to prevent the corks from falling. A torsion spring is provided on the outer wall of the rotating shaft, and the baffle is connected to the conveying track through the torsion spring.

[0008] Preferably, the bottle stopper disinfection assembly includes a protective frame to prevent ultraviolet light from overflowing. The protective frame is sleeved on the outside of the vertical plate and fixedly installed on the bottom end of the bottle stopper sorting mechanism. A driven lifting frame is slidably provided in the protective frame, and the driven lifting frame is slidably connected to the protective frame. An ultraviolet disinfection lamp is installed in the driven lifting frame. Two symmetrically distributed connecting plates are fixedly provided on the outside of the driven lifting frame, and the bottom end of the connecting plate is fixedly connected to the active lifting frame. The driven lifting frame is slidably connected to the vertical plate through a guide rail.

[0009] A method for preparing an aseptic filling and stoppering device for animal vaccines, comprising the following steps: S1. First, the vials used for filling vaccines are disinfected at high temperature by a high-temperature disinfection device, and then the disinfected vials are transported to the filling station for filling through a vial conveying device; S2. Place the stoppers into the stopper sorting mechanism, and after sorting the stoppers neatly through the stopper sorting mechanism, transfer them to the stopper conveying mechanism to facilitate the installation operation of the stoppers by the automatic stopper inserting device; S3. Fill the prepared animal vaccines into the corresponding vials through the automatic filling device. After filling, during the reset process of the automatic filling device, it drives the automatic stopper inserting device to install the stoppers on the filled vials, realizing the operation of inserting stoppers synchronously during the vaccine filling process; S4. During the stopper inserting process, the automatic stopper inserting device drives the ultraviolet disinfection lamp in the stopper disinfection assembly to reciprocate up and down to disinfect the stoppers in the stopper conveying mechanism.

[0010] Compared with the prior art, the beneficial effects of the present invention are as follows: 1. By setting the automatic filling device and the automatic stopper inserting device, during the reset process after filling the animal vaccines into the vials by the automatic filling device, it drives the automatic stopper inserting device to install the stoppers on the filled vials. Through the above operations, the effect of installing stoppers while filling is achieved, effectively improving the production efficiency, and at the same time reducing the possibility of contaminating the vaccines in the vials, better ensuring the quality and safety of the vaccines; 2. By setting the automatic stopper inserting device and the stopper disinfection assembly, when the active lifting frame in the automatic stopper inserting device moves up and down, it drives the ultraviolet disinfection lamp to reciprocate up and down synchronously through the driven lifting frame to disinfect and sterilize the stoppers, avoiding the possible secondary contamination of the stoppers during the waiting process after disinfection and before stopper inserting, and improving the aseptic guarantee level of vaccine production; 3. By setting the stopper conveying mechanism, the stoppers are guided by the stopper conveying mechanism to move orderly to the working position of the automatic stopper inserting device, and the cooperation of the torsion spring, the rotating shaft and the baffle can prevent the stoppers from falling. Description of the Drawings

[0011] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the following drawings are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.

[0012] Figure 1 It is a schematic diagram of the overall structure of the present invention; Figure 2Schematic partial upward view of the present invention; Figure 3 Schematic structural view of the automatic plugging device in the present invention; Figure 4 Schematic partial structural view of the automatic filling device in the present invention; Figure 5 Schematic overall structural view of the automatic filling device in the present invention; Figure 6 Schematic side structural view of the automatic plugging device in the present invention; Figure 7 Schematic partial structural view of the automatic plugging device in the present invention; Figure 8 Schematic structural view of the overall transmission in the present invention; Figure 9 is Figure 5 Schematic enlarged view of the structure at position A in Figure 10 is Figure 6 Schematic enlarged view of the structure at position B in

[0013] In the figure: 1, bottle conveying device; 2, automatic filling device; 201, base; 202, first fixed shaft; 203, turning plate; 204, rotating shaft; 205, fixed pulley; 206, moving pulley; 207, toothed belt; 208, filling platform; 209, driving shaft; 210, connecting shaft; 211, push rod; 212, driven rod; 213, electric cylinder; 214, driven shaft; 215, one-way bearing; 216, rotating gear; 217, semi-gear; 3, automatic plugging device; 301, plugging table; 302, second fixed shaft; 303, capping head; 304, active lifting frame; 305, guide shaft; 306, first transmission shaft; 307, rotating rod; 308, second transmission shaft; 309, third transmission shaft; 4, bottle stopper sorting mechanism; 5, bottle stopper conveying mechanism; 501, vertical plate; 502, conveying track; 503, rotating shaft; 504, baffle; 505, torsion spring; 6, bottle stopper disinfection assembly; 601, protective frame; 602, driven lifting frame; 603, ultraviolet disinfection lamp; 604, connecting plate. Detailed implementation manners

[0014] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0015] Embodiment: As Figures 1 - 10As shown in the figure, the present invention provides a technical solution: a sterile filling and plugging device for preparing animal vaccines, including a bottle conveying device 1, which is composed of a conveyor belt, a transmission mechanism, and a bottle holder, and is used to carry and transport vaccine bottles. On both sides of the bottle conveying device 1, there are respectively an automatic filling device 2 for filling the vaccine into the vial and an automatic plugging device 3 for sealing the vial mouth. Above the automatic plugging device 3, there is a bottle plug sorting mechanism 4 for sorting the messy bottle plugs into a neat queue. On the top of the automatic plugging device 3, there is a bottle plug conveying mechanism 5 that cooperates with the bottle plug sorting mechanism 4. Outside the bottle plug conveying mechanism 5, there is a bottle plug disinfection assembly 6; The automatic filling device 2 includes a base 201 and a first fixed shaft 202. The base 201 is fixedly installed at the top of the corresponding bracket. The first fixed shaft 202 is horizontally and fixedly installed in the base 201. Two symmetrically distributed turning plates 203 are rotatably sleeved on the outer wall of the first fixed shaft 202. Above the two turning plates 203, there is a rotating shaft 204 rotatably arranged. A fixed wheel 205 is fixedly sleeved on the outer wall of the first fixed shaft 202. A moving wheel 206 is fixedly sleeved on the outer wall of the rotating shaft 204. And a toothed belt 207 is sleeved on the outer walls of the fixed wheel 205 and the moving wheel 206. In the middle of the outer wall of the rotating shaft 204, there is a filling platform 208 fixedly sleeved; The automatic plugging device 3 includes a plugging table 301, which is fixedly installed at the top of the corresponding bracket. In the middle of the plugging table 301, there is a second fixed shaft 302 horizontally and fixedly arranged. A gland head 303 is rotatably sleeved on the outer wall of the second fixed shaft 302.

[0016] By adopting the above technical solution, while the automatic filling device 2 fills the animal vaccine, the automatic plugging device 3 installs the bottle plugs.

[0017] A driving shaft 209 is horizontally rotatably arranged below the base 201. In the middle between the two turning plates 203, there is a connecting shaft 210 fixedly arranged. And one end of the connecting shaft 210 penetrates through one side of the turning plate 203. A push rod 211 is fixedly arranged at the end of the driving shaft 209. The other end of the push rod 211 is rotatably provided with a driven rod 212. And the top end of the driven rod 212 is rotatably connected to the connecting shaft 210; There are four equally spaced filling heads on the filling platform 208. And the filling heads are connected to the liquid storage tank through metering pumps.

[0018] By adopting the above technical solution, the push rod 211 drives the driving shaft 209 to rotate synchronously.

[0019] The outer wall of the plug-in table 301 is slidably provided with an active lifting frame 304. Transverse grooves are formed on both sides of the active lifting frame 304, and arc grooves that cooperate with the transverse grooves are formed on both sides of the plug-in table 301. Both ends of the bottom of the capping head 303 are fixedly provided with guide shafts 305, and the guide shafts 305 slide in the transverse grooves and the arc grooves. A first transmission shaft 306 is rotatably provided in the middle of the fixed bracket on one side of the cork sorting mechanism 4. A rotating rod 307 is fixedly provided at the end of the first transmission shaft 306, and the end of the rotating rod 307 slides in the active lifting frame 304; Four pneumatic suction cups corresponding to the filling heads for fixing the corks are provided on the top of the capping head 303, and the pneumatic suction cups are connected to an external air source through air guide pipes.

[0020] By adopting the above technical solution, the capping head 303 rotates to install the cork.

[0021] The cork conveying mechanism 5 includes a vertical plate 501. The vertical plate 501 is fixedly installed at the top end of the plug-in table 301. Four conveying tracks 502 corresponding to the pneumatic suction cups for conveying the corks are fixedly provided on the outside of the vertical plate 501. The top end of the conveying track 502 corresponds to the discharge end of the cork sorting mechanism 4. A rotating shaft 503 is rotatably provided on one side of the bottom end of the conveying track 502. A baffle 504 for preventing the cork from falling is fixedly provided at the bottom end of the rotating shaft 503. A torsion spring 505 is sleeved on the outer wall of the rotating shaft 503, and the baffle 504 is connected to the conveying track 502 through the torsion spring 505.

[0022] By adopting the above technical solution, the cork is conveyed under the guidance of the conveying track 502.

[0023] The cork disinfection assembly 6 includes a protective frame 601 for preventing the overflow of ultraviolet rays. The protective frame 601 is sleeved on the outside of the vertical plate 501 and fixedly installed at the bottom end of the cork sorting mechanism 4. A driven lifting frame 602 is slidably provided in the protective frame 601, and the driven lifting frame 602 is slidably connected to the protective frame 601. An ultraviolet disinfection lamp 603 is installed in the driven lifting frame 602. Two symmetrically distributed connecting plates 604 are fixedly provided on the outside of the driven lifting frame 602, and the bottom ends of the connecting plates 604 are fixedly connected to the active lifting frame 304.

[0024] By adopting the above technical solution, the ultraviolet disinfection lamp 603 performs reciprocating lifting movement to disinfect and sterilize the cork.

[0025] A driven shaft 214 is rotatably provided directly below the base 201. A one-way bearing 215 is fixedly sleeved on the outer wall of the driven shaft 214. A rotating gear 216 is fixedly sleeved on the outer wall of the one-way bearing 215. A half gear 217 is fixedly provided at the end of the drive shaft 209, and the half gear 217 is meshed with the rotating gear 216.

[0026] By adopting the above technical solution, the driven shaft 214 rotates in one direction.

[0027] A third drive shaft 309 is horizontally rotatably provided at the bottom end of the plugging table 301, and the third drive shaft 309 is drivingly connected to the driven shaft 214 through a synchronous pulley drive set. A second drive shaft 308 is longitudinally rotatably provided at the bottom end of the plugging table 301, and the second drive shaft 308 is meshed with the third drive shaft 309 through a bevel gear. The second drive shaft 308 is drivingly connected to the first drive shaft 306 through a pulley drive set.

[0028] By adopting the above technical solution, the third drive shaft 309 drives the first drive shaft 306 to rotate through the second drive shaft 308.

[0029] An electric cylinder 213 is rotatably provided at the top end of the fixed bracket corresponding to the automatic filling device 2, and the driving end of the electric cylinder 213 is rotatably connected to the middle of the push rod 211.

[0030] By adopting the above technical solution, the electric cylinder 213 pushes the push rod 211 to rotate.

[0031] The active lifting frame 304 is slidably connected to the outer wall of the plugging table 301 through a guide rail, and the driven lifting frame 602 is slidably connected to the vertical plate 501 through a guide rail.

[0032] By adopting the above technical solution, the active lifting frame 304 and the driven lifting frame 602 are stably lifted and moved.

[0033] A method used for a sterile filling and plugging device for preparing animal vaccines includes the following steps: S1. First, the vials used for filling the vaccine are sterilized at high temperature through a high-temperature sterilization device, and then the sterilized vials are transported to the filling station through the vial conveying device 1 for filling; S2. Place the bottle stoppers into the bottle stopper sorting mechanism 4, and after sorting the bottle stoppers neatly through the bottle stopper sorting mechanism 4, transfer them to the bottle stopper conveying mechanism 5 to facilitate the installation operation of the automatic plugging device 3 on the bottle stoppers; S3. Fill the prepared animal vaccine into the corresponding vials through the automatic filling device 2. After filling, during the reset process of the automatic filling device ②, drive the automatic plugging device 3 to install the bottle stoppers in the vials after filling, so as to realize the plugging operation synchronously during the vaccine filling process; S4. During the plugging process, the automatic plugging device 3 drives the ultraviolet disinfection lamp 603 in the bottle stopper disinfection assembly 6 to reciprocally lift and move to disinfect the bottle stoppers in the bottle stopper conveying mechanism 5.

[0034] Working principle: When the vial is moved to directly below the automatic filling device 2 by the vial conveying device, the electric cylinder 213 is controlled to start. The driving end of the electric cylinder 213 extends to push the push rod 211 to rotate. The push rod 211 drives two turning plates 203 to turn 90° around the first fixed shaft 202 through the driven rod 212 and the connecting shaft 210. During this process, under the action of the fixed pulley 205, the moving pulley 206, the toothed belt 207 and the rotating shaft 204, the filling platform 208 is always kept in a horizontal state. When the turning plate 203 turns 90°, at this time, the four filling heads are respectively located in the corresponding vials for filling. During the rotation of the push rod 211, the driving shaft 209 is driven to rotate. At this time, under the action of the one-way bearing 215, the driving shaft 209 cannot drive the driven shaft 214 to rotate through the half gear 217 and the rotating gear 216. After the filling is completed, the driving end of the electric cylinder 213 contracts and resets. During this process, under the action of the one-way bearing 215, the driving shaft 209 drives the driven shaft 214 to rotate one week through the half gear 217 and the rotating gear 216. The driven shaft 214 drives the third transmission shaft 309 to rotate one week through the synchronous pulley transmission group. The third transmission shaft 309 drives the second transmission shaft 308 to rotate one week through the bevel gear group. The second transmission shaft 308 drives the first transmission shaft 306 to rotate one week through the synchronous pulley transmission group; When the first transmission shaft 306 rotates the first half week, it drives the active lifting frame 304 to rise through the rotating rod 307. During the rising process of the active lifting frame 304, under the action of the straight groove and the arc groove, the pressing head 303 is driven to turn around the second fixed shaft 302 through the guide shaft 305. During the rotation of the pressing head 303, the pneumatic suction cup contacts the bottle stopper in the conveying track 502 and adsorbs and fixes the bottle stopper to drive the bottle stopper to turn 90°, and inserts the bottle stopper into the vial after filling. When the first transmission shaft 306 rotates the second half week, the pressing head 303 is driven to turn and reset according to the same steps as above; During the process of the active lifting frame 304 reciprocating up and down once, it drives the driven lifting frame 602 to lift and move synchronously and cooperates with the ultraviolet disinfection lamp 603 to disinfect the bottle stopper, and this process is repeated in a cycle.

[0035] Obviously, those skilled in the art can make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. Thus, if these modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalent technologies, the present invention is also intended to include these changes and modifications.

Claims

1. A sterile filling and stoppering device for preparing animal vaccines, comprising a bottle conveying device (1), characterized in that: The bottle conveying device (1) consists of a conveyor belt, a transmission mechanism, and bottle supports, and is used to carry and transport vaccine bottles. On both sides of the bottle conveying device (1), there are respectively an automatic filling device (2) for filling vaccines into vials and an automatic plugging device (3) for sealing the mouths of vials. Above the automatic plugging device (3), there is a stopper sorting mechanism (4) for sorting messy stoppers into an orderly queue. On the top of the automatic plugging device (3), there is a stopper conveying mechanism (5) that cooperates with the stopper sorting mechanism (4). On the outside of the stopper conveying mechanism (5), there is a stopper disinfection component (6). The automatic filling device (2) includes a base (201) and a first fixed shaft (202). The base (201) is fixedly installed at the top of the corresponding bracket. The first fixed shaft (202) is horizontally and fixedly installed in the base (201). Two symmetrically distributed turning plates (203) are rotatably sleeved on the outer wall of the first fixed shaft (202). Above the two turning plates (203), a rotating shaft (204) is rotatably provided. A fixed pulley (205) is fixedly sleeved on the outer wall of the first fixed shaft (202). A moving pulley (206) is fixedly sleeved on the outer wall of the rotating shaft (204). A toothed belt (207) is sleeved on the outer walls of the fixed pulley (205) and the moving pulley (206). In the middle of the outer wall of the rotating shaft (204), a filling platform (208) is fixedly sleeved. The automatic plugging device (3) includes a plugging table (301). The plugging table (301) is fixedly installed at the top of the corresponding bracket. In the middle of the plugging table (301), a second fixed shaft (302) is horizontally and fixedly provided. A capping head (303) is rotatably sleeved on the outer wall of the second fixed shaft (302).

2. The aseptic filling and plugging device for preparing animal vaccines according to claim 1, wherein, A driving shaft (209) is horizontally rotatably provided below the base (201). In the middle between the two turning plates (203), a connecting shaft (210) is fixedly provided. One end of the connecting shaft (210) penetrates through one side of the turning plate (203). A push rod (211) is fixedly provided at the end of the driving shaft (209). A driven rod (212) is rotatably provided at the other end of the push rod (211). The top end of the driven rod (212) is rotatably connected to the connecting shaft (210). There are four equidistantly distributed filling heads on the filling platform (208), and the filling heads are connected to the liquid storage tank through metering pumps.

3. A sterile filling and stoppering device for preparing animal vaccines according to claim 1, characterized in that, An active lifting frame (304) is slidably provided on the outer wall of the plugging table (301). Transverse grooves are provided on both sides of the active lifting frame (304). Arc-shaped grooves that cooperate with the transverse grooves are provided on both sides of the plugging table (301). Guide shafts (305) are fixedly provided at both bottom sides of the capping head (303), and the guide shafts (305) slide in the transverse grooves and the arc-shaped grooves. In the middle of the fixed bracket on one side of the stopper sorting mechanism (4), a first transmission shaft (306) is rotatably provided. A rotating rod (307) is fixedly provided at the end of the first transmission shaft (306), and the end of the rotating rod (307) slides in the active lifting frame (304). There are four pneumatic suction cups for fixing stoppers corresponding to the filling heads on the top of the capping head (303), and the pneumatic suction cups are connected to an external air source through air ducts.

4. The aseptic filling and plugging device for preparing animal vaccines according to claim 1, characterized in that, The bottle stopper conveying mechanism (5) comprises a vertical plate (501), which is fixedly mounted on the top of the stoppering platform (301). Four conveying tracks (502) corresponding to the pneumatic suction cups for conveying the bottle stoppers are fixedly provided on the outside of the vertical plate (501). The top of the conveying track (502) corresponds to the discharge end of the bottle stopper sorting mechanism (4). A rotating shaft (503) is rotatably provided on one side of the bottom end of the conveying track (502). A baffle (504) for preventing the bottle stoppers from falling is fixedly provided on the bottom end of the rotating shaft (503). A torsion spring (505) is provided on the outer wall of the rotating shaft (503), and the baffle (504) is connected to the conveying track (502) via the torsion spring (505).

5. The aseptic filling and plugging device for preparing animal vaccines according to claim 1, wherein, The bottle stopper disinfection assembly (6) includes a protective frame (601) for preventing ultraviolet light from overflowing. The protective frame (601) is sleeved on the outside of the vertical plate (501) and fixedly mounted on the bottom end of the bottle stopper arrangement mechanism (4). A driven lifting frame (602) is slidably mounted in the protective frame (601), and the driven lifting frame (602) is slidably connected to the protective frame (601). An ultraviolet disinfection lamp (603) is mounted in the driven lifting frame (602). Two symmetrically distributed connecting plates (604) are fixedly mounted on the outside of the driven lifting frame (602), and the bottom ends of the connecting plates (604) are fixedly connected to the active lifting frame (304).

6. The aseptic filling and plugging device for preparing animal vaccines according to claim 1, wherein A driven shaft (214) is rotatably provided directly below the base (201), a one-way bearing (215) is fixedly provided on the outer wall of the driven shaft (214), a rotating gear (216) is fixedly provided on the outer wall of the one-way bearing (215), and a half gear (217) is fixedly provided at the end of the driving shaft (209), and the half gear (217) is meshedly connected with the rotating gear (216).

7. The aseptic filling and plugging device for preparing animal vaccines according to claim 1, wherein, The bottom end of the plugging platform (301) is provided with a third transmission shaft (309) for horizontal rotation, and the third transmission shaft (309) is connected to the driven shaft (214) through a synchronous wheel transmission group. The bottom end of the plugging platform (301) is provided with a second transmission shaft (308) for longitudinal rotation, and the second transmission shaft (308) is connected to the third transmission shaft (309) through a bevel gear meshing connection, and the second transmission shaft (308) is connected to the first transmission shaft (306) through a pulley transmission group.

8. The aseptic filling and plugging device for preparing animal vaccines according to claim 1, characterized in that, An electric cylinder (213) is rotatably provided at the top end of the fixed bracket corresponding to the automatic filling device (2), and a driving end of the electric cylinder (213) is rotatably connected to the middle of the push rod (211).

9. The aseptic filling and plugging device for preparing animal vaccines according to claim 3, wherein, The active lifting frame (304) is slidably connected to the outer wall of the plugging platform (301) via a guide rail, and the driven lifting frame (602) is slidably connected to the vertical plate (501) via a guide rail.

10. A method used for an aseptic filling and plugging device for preparing animal vaccines according to any one of claims 1-9, characterized in that, The following steps are involved: S1. First, the vials used for filling the vaccine are sterilized by a high-temperature sterilizer, and then the sterilized vials are transported to the filling station for filling by a bottle conveyor (1); S2, placing the bottle corks into the bottle cork arranging mechanism (4), arranging the bottle corks by the bottle cork arranging mechanism (4) and transferring them to the bottle cork conveying mechanism (5), so that the automatic corking device (3) can install the bottle corks; S3. The prepared animal vaccine is filled into the corresponding vials through the automatic filling device (2). After filling, during the reset process of the automatic filling device (2), the automatic stopper-inserting device (3) is driven to install the stopper in the vial after filling, realizing the stopper-inserting operation synchronously during the vaccine filling process; S4. During the stopper-inserting process, the automatic stopper-inserting device (3) drives the ultraviolet disinfection lamp (603) in the stopper disinfection assembly (6) to reciprocate up and down to disinfect the stoppers in the stopper conveying mechanism (5).

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