Continuous blood glucose monitoring equipment control method, device and equipment

Abstract

The invention relates to a control method, device and equipment for continuous blood glucose monitoring equipment, the continuous blood glucose monitoring equipment comprises an electrochemical sensor, and the method comprises the steps that corresponding bias voltages are loaded to a working electrode of the electrochemical sensor and an auxiliary electrode of the electrochemical sensor respectively, the voltage difference between the bias voltage loaded to the working electrode and the bias voltage loaded to the auxiliary electrode is a first voltage difference, and the first voltage difference is a voltage difference required when a substance participating in an electrochemical reaction in the electrochemical sensor is glucose; detecting to obtain an actual voltage value of the working electrode and an actual voltage value of the auxiliary electrode; determining a second voltage difference according to the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode; under the condition that the absolute value of the difference value of the first voltage difference and the second voltage difference is larger than a preset threshold value, the bias voltage loaded to the auxiliary electrode is adjusted, so that the absolute value of the difference value of the first voltage difference and the second voltage difference is smaller than or equal to the preset threshold value.

Description

Technical Field

[0001] The present disclosure relates to blood glucose monitoring technology, and more particularly, to a control method, device, and equipment for a continuous blood glucose monitoring device. Background Art

[0002] In a continuous glucose monitoring (CGM) device, glucose in interstitial fluid undergoes an electrochemical reaction with an active substance on an electrochemical sensor to generate a current, and based on this current, the concentration of glucose in interstitial fluid can be determined.

[0003] In addition to glucose, there are various electrochemically active substances in interstitial fluid, such as uric acid, ascorbic acid, etc. These substances also undergo electrochemical reactions on the electrochemical sensor, generating interference signals and affecting the accuracy and stability of glucose measurement.

[0004] Therefore, a technical solution is needed to inhibit the reaction of interfering substances in interstitial fluid and achieve noise reduction. Summary of the Invention

[0005] An object of the present invention is to provide a new technical solution for a control method of a continuous blood glucose monitoring device.

[0006] According to a first aspect of the present invention, there is provided a control method for a continuous blood glucose monitoring device, the continuous blood glucose monitoring device including an electrochemical sensor, the method comprising: Applying corresponding bias voltages to a working electrode and a counter electrode of the electrochemical sensor respectively, wherein a voltage difference between the bias voltage applied to the working electrode and the bias voltage applied to the counter electrode is a first voltage difference, and the first voltage difference is the voltage difference required when the substance participating in the electrochemical reaction in the electrochemical sensor is glucose; Detecting an actual voltage value of the working electrode and an actual voltage value of the counter electrode; Determining a second voltage difference based on the actual voltage value of the working electrode and the actual voltage value of the counter electrode; In a case where an absolute value of a difference between the first voltage difference and the second voltage difference is greater than a preset threshold, adjusting the bias voltage applied to the counter electrode so that the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to the preset threshold.

[0007] Optionally, the bias voltage applied to the working electrode is a voltage required for glucose to generate an electrochemical reaction in the electrochemical sensor.

[0008] Optionally, adjusting the bias voltage applied to the auxiliary electrode so that the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to the preset threshold includes: When the second voltage difference is greater than the first voltage difference, increasing the bias voltage applied to the auxiliary electrode; When the second voltage difference is less than the first voltage difference, decreasing the bias voltage applied to the auxiliary electrode.

[0009] Optionally, adjusting the bias voltage applied to the auxiliary electrode so that the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to the preset threshold includes: Adjusting the bias voltage applied to the auxiliary electrode based on a preset voltage step; Redetecting the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode; Determining a new second voltage difference according to the redetected actual voltage value of the working electrode and the redetected actual voltage value of the auxiliary electrode; When the absolute value of the difference between the first voltage difference and the new second voltage difference is greater than the preset threshold, continuing to adjust the bias voltage applied to the auxiliary electrode based on the preset voltage step until the absolute value of the difference between the first voltage difference and the determined new second voltage difference is less than or equal to the preset threshold.

[0010] Optionally, the continuous blood glucose monitoring device further includes an analog-to-digital conversion unit and a switch. The analog-to-digital conversion unit is connected to the switch. The switch is provided with a channel connected to the working electrode and a channel connected to the auxiliary electrode. Among them, Detecting the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode and determining the second voltage difference includes: When the connection channel between the switch and the working electrode is turned on, collecting the actual voltage value of the working electrode through the analog-to-digital conversion unit; When the connection channel between the switch and the auxiliary electrode is turned on, collecting the actual voltage value of the auxiliary electrode through the analog-to-digital conversion unit.

[0011] Optionally, the continuous blood glucose monitoring device further includes an extraction electrode. Among them, When the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to the preset threshold, the method further includes: Obtaining the current generated by the electrochemical reaction based on the electrochemical reaction generated by the tissue fluid extracted by the extraction electrode in the electrochemical sensor; Determine the concentration of glucose in the interstitial fluid based on the current generated by the electro-chemical reaction.

[0012] According to a second aspect of the present invention, there is provided a control device for a continuous blood glucose monitoring device, comprising: A voltage loading module for respectively loading corresponding bias voltages to a working electrode and a counter electrode of an electro-chemical sensor in the continuous blood glucose monitoring device, wherein a voltage difference between the bias voltage loaded to the working electrode and the bias voltage loaded to the counter electrode is a first voltage difference, and the first voltage difference is the voltage difference required when the substance participating in the electro-chemical reaction in the electro-chemical sensor is glucose; A voltage detection module for detecting the actual voltage value of the working electrode and the actual voltage value of the counter electrode; A voltage difference determination module for determining a second voltage difference according to the actual voltage value of the working electrode and the actual voltage value of the counter electrode; An adjustment module for adjusting the bias voltage loaded to the counter electrode when the absolute value of the difference between the first voltage difference and the second voltage difference is greater than a preset threshold, so that the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to the preset threshold.

[0013] According to a third aspect of the present invention, there is provided a control device for a continuous blood glucose monitoring device, comprising a memory and a processor, wherein the memory stores a computer program, and the computer program is used to control the processor to operate to execute the method according to any one of the first aspects.

[0014] According to a fourth aspect of the present invention, there is provided a continuous blood glucose monitoring device, comprising: the control device according to the second aspect or the third aspect, an AFE unit, and an electro-chemical sensor, wherein the control device is connected to the AFE unit, and three electrodes in the electro-chemical sensor are all connected to the AFE unit, and the three electrodes include a working electrode, a reference electrode, and a counter electrode.

[0015] Optionally, the device further comprises an analog-to-digital conversion unit and a switch, one end of the analog-to-digital conversion unit is connected to the control device, the other end of the analog-to-digital conversion unit is connected to the switch, and the switch is provided with a channel connected to the working electrode and a channel connected to the counter electrode, wherein, The control device is further configured to collect the actual voltage value of the working electrode through the analog-to-digital conversion unit when the connection channel between the switch and the working electrode is turned on; Collect the actual voltage value of the counter electrode through the analog-to-digital conversion unit when the connection channel between the switch and the counter electrode is turned on.

[0016] The control method provided by the present invention precisely controls the voltage difference between the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode, making the voltage difference between the two suitable for glucose, the substance participating in the electrochemical reaction in the electrochemical sensor, and inhibiting other substances in the tissue fluid from participating in the electrochemical reaction, thereby improving the accuracy and reliability of measuring the glucose concentration in the tissue fluid. In addition, the control method provided by the embodiments of the present invention is a real-time feedback control, so that the continuous blood glucose monitoring device can operate stably under different environmental conditions, improving the reliability of the device and the user experience.

[0017] Through the following detailed description of the exemplary embodiments of this specification with reference to the accompanying drawings, the features and advantages of the embodiments of this specification will become clear. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] The drawings incorporated in and constituting a part of this specification illustrate the embodiments of this specification and, together with the description, are used to explain the principles of the embodiments of this specification.

[0019] Figure 1 is a schematic flowchart of a control method for a continuous blood glucose monitoring device according to an embodiment of the present invention.

[0020] Figure 2 is a schematic block diagram of the principle of a control device for a continuous blood glucose monitoring device according to an embodiment of the present invention.

[0021] Figure 3 is a schematic structural diagram of a control device for a continuous blood glucose monitoring device according to an embodiment of the present invention.

[0022] Figure 4 is a schematic structural diagram of a continuous blood glucose monitoring device according to an embodiment of the present invention.

[0023] Figure 5 is a schematic structural diagram of a continuous blood glucose monitoring device according to an embodiment of the present invention. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0024] Now, various exemplary embodiments of this specification will be described in detail with reference to the accompanying drawings.

[0025] The following description of at least one exemplary embodiment is merely illustrative in nature and is in no way intended to limit the embodiments of this specification, their applications, or uses.

[0026] It should be noted that like reference numerals and letters denote like items in the following drawings, and thus, once an item is defined in one drawing, it need not be further discussed in subsequent drawings.

[0027] In an embodiment of the present invention, a method for controlling a continuous blood glucose monitoring device is provided. This method is applied to a continuous blood glucose monitoring device.

[0028] The continuous blood glucose monitoring device includes an electrochemical sensor. The electrochemical sensor has a three-electrode structure, namely a working electrode (WE, Working Electrode), a reference electrode (RE, Reference Electrode), and a counter electrode (CE, Counter Electrode). Glucose in interstitial fluid can undergo an electrochemical reaction with the reaction enzyme in the electrochemical sensor to generate a current. The concentration of glucose in interstitial fluid is determined by the current value generated by the electrochemical reaction of the electrochemical sensor.

[0029] According to Figure 1 As shown, the method for controlling the continuous blood glucose monitoring device in this embodiment includes the following steps S110 to S140.

[0030] Step S110: Apply corresponding bias voltages to the working electrode and the counter electrode of the electrochemical sensor respectively. Among them, the voltage difference between the bias voltage applied to the working electrode and the bias voltage applied to the counter electrode is the first voltage difference, and the first voltage difference is the voltage difference required when the substance participating in the electrochemical reaction in the electrochemical sensor is glucose.

[0031] The bias voltage applied to the working electrode of the electrochemical sensor and the bias voltage applied to the counter electrode of the electrochemical sensor are both pre-stored values and can be directly obtained.

[0032] The bias voltage applied to the working electrode determines the intensity of the electrochemical reaction generated by glucose in the electrochemical sensor. In this embodiment, the bias voltage applied to the working electrode is the voltage required to satisfy the electrochemical reaction of glucose in the electrochemical sensor.

[0033] The voltage difference between the bias voltage applied to the working electrode and the bias voltage applied to the counter electrode determines the type of substance participating in the electrochemical reaction in interstitial fluid. In this embodiment, the first voltage difference is the voltage difference required when the substance participating in the electrochemical reaction in the electrochemical sensor is only glucose, and the first voltage difference can inhibit other substances in interstitial fluid from participating in the electrochemical reaction.

[0034] Step S120: Detect the actual voltage value of the working electrode and the actual voltage value of the counter electrode.

[0035] Due to the influence of its own structure and the external environment, the actual voltage value of the working electrode is not the same as the bias voltage applied to the working electrode, and the actual voltage value of the counter electrode is not the same as the bias voltage applied to the counter electrode. Therefore, it is necessary to detect the actual voltage value of the working electrode and the actual voltage value of the counter electrode.

[0036] In some embodiments, the continuous blood glucose monitoring device further includes an analog-to-digital conversion unit and a switch. The analog-to-digital conversion unit is connected to the switch, and the switch is provided with a channel connected to the working electrode and a channel connected to the auxiliary electrode.

[0037] Step S120 specifically includes: when the connection channel between the switch and the working electrode is turned on, collecting the actual voltage value of the working electrode through the analog-to-digital conversion unit; when the connection channel between the switch and the auxiliary electrode is turned on, collecting the actual voltage value of the auxiliary electrode through the analog-to-digital conversion unit.

[0038] In this embodiment, the combined use of the analog-to-digital conversion unit and the switch can realize the acquisition and switching of multi-channel voltage signals. The voltage values of multiple electrodes are collected using the same analog-to-digital conversion unit, reducing the hardware complexity and cost.

[0039] Step S130: Determine the second voltage difference according to the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode.

[0040] Step S140: When the absolute value of the difference between the first voltage difference and the second voltage difference is greater than a preset threshold, adjust the bias voltage applied to the auxiliary electrode so that the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to the preset threshold.

[0041] When the absolute value of the difference between the first voltage difference and the second voltage difference is greater than the preset threshold, it is determined that the voltage difference between the actual voltage value of the current working electrode and the actual voltage value of the auxiliary electrode is not suitable for glucose to participate in the electrochemical reaction, and other substances in the tissue fluid may participate in the electrochemical reaction. In addition, since the bias voltage applied to the working electrode determines the intensity of the electrochemical reaction generated by glucose in the electrochemical sensor, in order not to affect the electrochemical reaction generated by glucose in the electrochemical sensor, after applying the corresponding bias voltage to the working electrode, the bias voltage applied to the working electrode is no longer adjusted, but the bias voltage applied to the auxiliary electrode is adjusted so that the voltage difference between the actual voltage value of the current working electrode and the actual voltage value of the auxiliary electrode is suitable for glucose to participate in the electrochemical reaction.

[0042] When the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to the preset threshold, it is determined that the voltage difference between the actual voltage value of the current working electrode and the actual voltage value of the auxiliary electrode is suitable for glucose to participate in the electrochemical reaction, and at the same time, other substances in the tissue fluid participating in the electrochemical reaction can be inhibited.

[0043] In some embodiments, adjusting the bias voltage applied to the auxiliary electrode such that the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to a preset threshold specifically includes: when the second voltage difference is greater than the first voltage difference, increasing the bias voltage applied to the auxiliary electrode; when the second voltage difference is less than the first voltage difference, decreasing the bias voltage applied to the auxiliary electrode.

[0044] When the second voltage difference is greater than the first voltage difference, increasing the bias voltage applied to the auxiliary electrode causes the actually measured voltage value of the auxiliary electrode to increase, and further causes the voltage difference between the actually measured voltage value of the current working electrode and the actually measured voltage value of the auxiliary electrode to decrease, so as to be suitable for glucose to participate in the electrochemical reaction.

[0045] When the second voltage difference is less than the first voltage difference, decreasing the bias voltage applied to the auxiliary electrode causes the actually measured voltage value of the auxiliary electrode to decrease, and further causes the voltage difference between the actually measured voltage value of the current working electrode and the actually measured voltage value of the auxiliary electrode to increase, so as to be suitable for glucose to participate in the electrochemical reaction.

[0046] In some embodiments, adjusting the bias voltage applied to the auxiliary electrode such that the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to a preset threshold specifically includes: based on a preset voltage step, adjusting the bias voltage applied to the auxiliary electrode; re-detecting the actually measured voltage value of the working electrode and the actually measured voltage value of the auxiliary electrode; determining a new second voltage difference according to the re-detected actually measured voltage value of the working electrode and the re-detected actually measured voltage value of the auxiliary electrode; when the absolute value of the difference between the first voltage difference and the new second voltage difference is greater than the preset threshold, continuing to adjust the bias voltage applied to the auxiliary electrode based on the preset voltage step until the absolute value of the difference between the first voltage difference and the determined new second voltage difference is less than or equal to the preset threshold.

[0047] When the second voltage difference is greater than the first voltage difference, based on a preset voltage step, increasing the bias voltage applied to the auxiliary electrode, and re-detecting the actually measured voltage value of the working electrode and the actually measured voltage value of the auxiliary electrode. Determining a new second voltage difference according to the re-detected actually measured voltage value of the working electrode and the re-detected actually measured voltage value of the auxiliary electrode. When the absolute value of the difference between the first voltage difference and the new second voltage difference is greater than the preset threshold, continuing to increase the bias voltage applied to the auxiliary electrode based on the preset voltage step until the absolute value of the difference between the first voltage difference and the determined second voltage difference is less than or equal to the preset threshold.

[0048] When the second voltage difference is less than the first voltage difference, based on a preset voltage step, the bias voltage applied to the auxiliary electrode is lowered, and the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode are re-detected. According to the re-detected actual voltage value of the working electrode and the re-detected actual voltage value of the auxiliary electrode, a new second voltage difference is determined. When the absolute value of the difference between the first voltage difference and the new second voltage difference is greater than a preset threshold, continue to lower the bias voltage applied to the auxiliary electrode based on the preset voltage step until the absolute value of the difference between the first voltage difference and the determined second voltage difference is less than or equal to the preset threshold.

[0049] By gradually adjusting the bias voltage of the auxiliary electrode through a preset voltage step, the potential difference between the working electrode and the auxiliary electrode can be precisely controlled, which can avoid the problem of over-adjustment during the voltage adjustment process and improve the stability of voltage adjustment.

[0050] In some embodiments, the continuous blood glucose monitoring device further includes a sampling electrode. When the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to a preset threshold, the method further includes: obtaining the current generated by the electrochemical reaction based on the electrochemical reaction of the tissue fluid sampled by the sampling electrode in the electrochemical sensor; and determining the concentration of glucose in the tissue fluid according to the current generated by the electrochemical reaction.

[0051] The continuous blood glucose monitoring device further includes an AFE (Active Front End) unit. The working electrode, the reference electrode, and the auxiliary electrode in the electrochemical sensor are all connected to the AFE unit.

[0052] Glucose in the tissue fluid sampled by the sampling electrode can undergo an electrochemical reaction with the reaction enzyme in the electrochemical sensor. Under the action of electrochemistry, the reference electrode RE and the auxiliary electrode CE in the electrochemical sensor are short-circuited to form an electrode RCE. The current generated by the electrochemical reaction of the electrochemical sensor flows out through the working electrode of the electrochemical sensor, flows through the feedback resistor in the AFE unit, and then flows into the electrochemical sensor through the electrode RCE. First, determine the voltage value across the feedback resistor, and calculate the current generated by the electrochemical reaction of the electrochemical sensor according to the voltage value across the feedback resistor and the resistance of the feedback resistor.

[0053] The control method provided by the embodiment of the present invention precisely controls the voltage difference between the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode, making the voltage difference between the two suitable for glucose, the substance participating in the electrochemical reaction in the electrochemical sensor, and inhibiting other substances in the tissue fluid from participating in the electrochemical reaction, thereby improving the accuracy and reliability of measuring the glucose concentration in the tissue fluid. In addition, the control method provided by the embodiment of the present invention is a real-time feedback control, so that the continuous blood glucose monitoring device can operate stably under different environmental conditions, improving the reliability of the device and the user experience.

[0054] An embodiment of the present invention provides a control device for a continuous blood glucose monitoring device. According to Figure 2 As shown, the control device 200 for a continuous blood glucose monitoring device includes a voltage loading module 210, a voltage monitoring module 220, a voltage difference determination module 230, and an adjustment module 240.

[0055] The voltage loading module 210 is configured to respectively load corresponding bias voltages to the working electrode of the electrochemical sensor and the auxiliary electrode of the electrochemical sensor in the continuous blood glucose monitoring device. Among them, the voltage difference between the bias voltage loaded to the working electrode and the bias voltage loaded to the auxiliary electrode is a first voltage difference, and the first voltage difference is the voltage difference required when glucose is the substance participating in the electrochemical reaction in the electrochemical sensor.

[0056] The voltage detection module 220 is configured to detect the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode.

[0057] The voltage difference determination module 230 is configured to determine a second voltage difference according to the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode.

[0058] The adjustment module 240 is configured to adjust the bias voltage loaded to the auxiliary electrode when the absolute value of the difference between the first voltage difference and the second voltage difference is greater than a preset threshold, so that the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to the preset threshold.

[0059] In some embodiments, the bias voltage loaded to the working electrode is the voltage required for glucose to generate an electrochemical reaction in the electrochemical sensor.

[0060] In some embodiments, the adjustment module 240 is further configured to increase the bias voltage loaded to the auxiliary electrode when the second voltage difference is greater than the first voltage difference; and decrease the bias voltage loaded to the auxiliary electrode when the second voltage difference is less than the first voltage difference.

[0061] In some embodiments, the adjustment module 240 is further configured to adjust the bias voltage applied to the auxiliary electrode based on a preset voltage step; re-detect the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode; determine a new second voltage difference according to the re-detected actual voltage value of the working electrode and the re-detected actual voltage value of the auxiliary electrode; and when the absolute value of the difference between the first voltage difference and the new second voltage difference is greater than a preset threshold, continue to adjust the bias voltage applied to the auxiliary electrode based on the preset voltage step until the absolute value of the difference between the first voltage difference and the determined new second voltage difference is less than or equal to the preset threshold.

[0062] In some embodiments, the continuous blood glucose monitoring device further includes an analog-to-digital conversion unit and a switch. The analog-to-digital conversion unit is connected to the switch, and the switch is provided with a channel connected to the working electrode and a channel connected to the auxiliary electrode. The voltage detection module 220 is further configured to collect the actual voltage value of the working electrode through the analog-to-digital conversion unit when the connection channel between the switch and the working electrode is turned on; When the connection channel between the switch and the auxiliary electrode is turned on, collect the actual voltage value of the auxiliary electrode through the analog-to-digital conversion unit.

[0063] In some embodiments, the continuous blood glucose monitoring device further includes a sampling electrode. The device further includes a glucose concentration measurement module. The glucose concentration measurement module is configured to, when the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to a preset threshold, obtain the current generated by the electrochemical reaction based on the electrochemical reaction generated by the tissue fluid extracted by the sampling electrode in the electrochemical sensor; and determine the glucose concentration in the tissue fluid according to the current generated by the electrochemical reaction.

[0064] The control device of the continuous blood glucose monitoring device is an MCU (Microcontroller Unit).

[0065] An embodiment of the present invention provides a control device for a continuous blood glucose monitoring device. According to Figure 3 As shown, the control device 300 of the continuous blood glucose monitoring device includes a memory 320 and a processor 310. The memory 320 stores a computer program, and the computer program is used to control the processor 310 to operate to execute the control method provided in any of the above embodiments.

[0066] An embodiment of the present invention provides a continuous blood glucose monitoring device. According to Figure 4 As shown, the continuous blood glucose monitoring device includes the control device, an AFE unit, and an electrochemical sensor provided in any of the above embodiments. The control device is connected to the AFE unit. All three electrodes in the electrochemical sensor are connected to the AFE unit, and the three electrodes include a working electrode, a reference electrode, and an auxiliary electrode.

[0067] The control device applies corresponding bias voltages to the working electrode and the auxiliary electrode of the electrochemical sensor through the AFE unit.

[0068] The working electrode, reference electrode, and auxiliary electrode in the electrochemical sensor are all connected to the AFE unit. Glucose in the interstitial fluid extracted by the extraction electrode can undergo an electrochemical reaction with the reaction enzyme in the electrochemical sensor. Under the action of electrochemistry, the reference electrode RE and the auxiliary electrode CE in the electrochemical sensor are short-circuited to form an electrode RCE. The current generated by the electrochemical reaction in the electrochemical sensor flows out through the working electrode of the electrochemical sensor, passes through the feedback resistor in the AFE unit, and then flows into the electrochemical sensor through the electrode RCE.

[0069] According to Figure 5 As shown, the continuous blood glucose monitoring device further includes an analog-to-digital conversion unit and a switch. One end of the analog-to-digital conversion unit is connected to the control device, and the other end of the analog-to-digital conversion unit is connected to the switch. The switch is provided with a channel connected to the working electrode and a channel connected to the auxiliary electrode.

[0070] The control device is further configured to collect the actual voltage value of the working electrode through the analog-to-digital conversion unit when the connection channel between the switch and the working electrode is turned on; and collect the actual voltage value of the auxiliary electrode through the analog-to-digital conversion unit when the connection channel between the switch and the auxiliary electrode is turned on.

[0071] According to Figure 5 As shown, the control device is also connected to the switch. The control device controls the connection channel between the switch and the working electrode or the connection channel between the switch and the auxiliary electrode by controlling the level of the interface connected to the switch. For example, when the control device controls the level of the interface connected to the switch to be high, it controls the connection channel between the switch and the auxiliary electrode to be turned on, that is, the A-C channel is turned on; when the control device controls the level of the interface connected to the switch to be low, it controls the connection channel between the switch and the working electrode to be turned on, that is, the B-C channel is turned on. It should be noted that under the action of electrochemistry, the reference electrode RE and the auxiliary electrode CE in the electrochemical sensor are short-circuited to form an electrode RCE. Therefore, the actual voltage values corresponding to both the reference electrode RE and the auxiliary electrode CE are the same voltage value.

[0072] According to Figure 5 As described above, the continuous blood glucose monitoring device further includes a DC-DC unit and an extraction electrode. One end of the DC-DC unit is connected to the control device, and the other end of the DC-DC unit is connected to the extraction electrode. The control device is configured to control the extraction electrode to extract interstitial fluid through the DC-DC unit.

[0073] Each embodiment in this specification is described in a progressive manner. For the same or similar parts among the embodiments, reference can be made to each other, and the key point of each embodiment is to illustrate the differences from other embodiments.

[0074] The above describes specific embodiments of this specification. Other embodiments are within the scope of the appended claims. In some cases, the actions or steps recited in the claims can be performed in a different order than in the embodiments and still achieve the desired result. Additionally, the processes depicted in the figures do not necessarily require the specific order or sequential order shown to achieve the desired result. In certain embodiments, multitasking and parallel processing are also possible or may be advantageous.

[0075] The embodiments of this specification can be systems, methods, and / or computer program products. The computer program product can include a computer-readable storage medium having thereon computer instructions for causing a processor to implement various aspects of the embodiments of this specification.

[0076] A computer-readable storage medium can be a tangible device that can retain and store computer instructions for use by a computer instruction execution device. A computer-readable storage medium can be, for example, but not limited to, an electrical storage device, a magnetic storage device, an optical storage device, an electromagnetic storage device, a semiconductor storage device, or any suitable combination of the foregoing. More specific examples (non-exhaustive list) of the computer-readable storage medium include: a portable computer disk, a hard disk, a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), a static random access memory (SRAM), a portable compact disc read-only memory (CD-ROM), a digital versatile disc (DVD), a memory stick, a floppy disk, a mechanically encoded device such as a punched card or raised structures in grooves having computer instructions stored thereon, and any suitable combination of the foregoing. The computer-readable storage medium used herein is not construed as an instantaneous signal itself, such as a radio wave or other freely propagating electromagnetic wave, an electromagnetic wave propagating through a waveguide or other transmission medium (e.g., an optical pulse through an optical fiber cable), or an electrical signal transmitted through a wire.

[0077] The computer instructions described herein can be downloaded from the computer-readable storage medium to various computing / processing devices, or downloaded to an external computer or external storage device through a network, such as the Internet, a local area network, a wide area network, and / or a wireless network. The network can include a copper transmission cable, an optical fiber transmission, a wireless transmission, a router, a firewall, a switch, a gateway computer, and / or an edge server. The network adapter or network interface in each computing / processing device receives the computer instructions from the network and forwards the computer instructions for storage in the computer-readable storage medium in each computing / processing device.

[0078] The flowcharts and block diagrams in the accompanying drawings illustrate the architecture, functionality, and operation of possible implementations of systems, methods, and computer program products according to various embodiments of the present specification. In this regard, each block in the flowchart or block diagram may represent a module, a segment of a program, or a part of computer instructions, which contains one or more executable computer instructions for implementing the specified logical function. In some alternative implementations, the functions noted in the blocks may occur in an order different from that noted in the accompanying drawings. For example, two consecutive blocks may actually be executed substantially in parallel, or they may sometimes be executed in the reverse order, depending on the functions involved. It should also be noted that each block in the block diagram and / or flowchart, and combinations of blocks in the block diagram and / or flowchart, can be implemented by a dedicated hardware-based system that performs the specified functions or actions, or can be implemented by a combination of dedicated hardware and computer instructions. As is well known to those skilled in the art, implementation through hardware, implementation through software, and implementation through a combination of software and hardware are equivalent.

[0079] The embodiments of the present specification have been described above. The above description is exemplary and not exhaustive, and is not limited to the disclosed embodiments. Many modifications and variations are obvious to those of ordinary skill in the art in the technical field without departing from the scope of the described embodiments. The choice of terms used herein is intended to best explain the principles of the embodiments, practical applications, or improvements to the technology in the market, or to enable other ordinary skilled persons in the technical field to understand the embodiments disclosed herein.

Claims

1. A control method for a continuous blood glucose monitoring device, characterized in that The continuous blood glucose monitoring device includes an electrochemical sensor, and the method includes: Applying corresponding bias voltages to the working electrode and the auxiliary electrode of the electrochemical sensor respectively, wherein the voltage difference between the bias voltage applied to the working electrode and the bias voltage applied to the auxiliary electrode is a first voltage difference, and the first voltage difference is the voltage difference required when the substance participating in the electrochemical reaction in the electrochemical sensor is glucose; Detecting the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode; Determining a second voltage difference according to the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode; When the absolute value of the difference between the first voltage difference and the second voltage difference is greater than a preset threshold, adjusting the bias voltage applied to the auxiliary electrode so that the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to the preset threshold.

2. The method according to claim 1, characterized in that, The bias voltage applied to the working electrode is the voltage required for glucose to generate an electrochemical reaction in the electrochemical sensor.

3. The method according to claim 1, wherein The adjusting the bias voltage applied to the auxiliary electrode so that the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to the preset threshold includes: When the second voltage difference is greater than the first voltage difference, increasing the bias voltage applied to the auxiliary electrode; When the second voltage difference is less than the first voltage difference, decreasing the bias voltage applied to the auxiliary electrode.

4. The method according to claim 1, wherein The adjusting the bias voltage applied to the auxiliary electrode so that the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to the preset threshold includes: Adjusting the bias voltage applied to the auxiliary electrode based on a preset voltage step; Redetecting the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode; Determining a new second voltage difference according to the redetected actual voltage value of the working electrode and the redetected actual voltage value of the auxiliary electrode; When the absolute value of the difference between the first voltage difference and the new second voltage difference is greater than the preset threshold, continuing to adjust the bias voltage applied to the auxiliary electrode based on the preset voltage step until the absolute value of the difference between the first voltage difference and the determined new second voltage difference is less than or equal to the preset threshold.

5. The method according to claim 1, characterized in that, The continuous blood glucose monitoring device further includes an analog-to-digital conversion unit and a switch, the analog-to-digital conversion unit is connected to the switch, and the switch is provided with a channel connected to the working electrode and a channel connected to the auxiliary electrode, wherein, The detecting the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode and determining the second voltage difference includes: When the connection channel between the switch and the working electrode is turned on, collecting the actual voltage value of the working electrode through the analog-to-digital conversion unit; When the connection channel between the switch and the auxiliary electrode is turned on, collecting the actual voltage value of the auxiliary electrode through the analog-to-digital conversion unit.

6. The method according to any one of claims 1-5, characterized in that The continuous blood glucose monitoring device further includes a sampling electrode, wherein, When the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to the preset threshold, the method further includes: Based on the electrochemical reaction generated in the electrochemical sensor by the tissue fluid extracted by the extraction electrode, obtaining the current generated by the electrochemical reaction; Determining the concentration of glucose in the tissue fluid according to the current generated by the electrochemical reaction.

7. A control device for a continuous blood glucose monitoring device, characterized in that, Includes: A voltage loading module for respectively loading corresponding bias voltages to the working electrode and the auxiliary electrode of the electrochemical sensor in a continuous blood glucose monitoring device, wherein the voltage difference between the bias voltage loaded to the working electrode and the bias voltage loaded to the auxiliary electrode is the first voltage difference, and the first voltage difference is the voltage difference required when the substance participating in the electrochemical reaction in the electrochemical sensor is glucose; A voltage detection module for detecting the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode; A voltage difference determination module for determining a second voltage difference according to the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode; An adjustment module for adjusting the bias voltage loaded to the auxiliary electrode when the absolute value of the difference between the first voltage difference and the second voltage difference is greater than the preset threshold, so that the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to the preset threshold.

8. A control device for a continuous blood glucose monitoring device, characterized in that, Includes a memory and a processor, the memory stores a computer program, and the computer program is used to control the processor to operate to execute the method according to any one of claims 1 to 6.

9. A continuous blood glucose monitoring device, characterized in that, Includes: The control device, AFE unit and electrochemical sensor according to claim 7 or 8, wherein the control device is connected to the AFE unit, and the three electrodes in the electrochemical sensor are all connected to the AFE unit, and the three electrodes include a working electrode, a reference electrode and an auxiliary electrode.

10. The continuous blood glucose monitoring device according to claim 9, wherein, The device further includes an analog-to-digital conversion unit and a switch, one end of the analog-to-digital conversion unit is connected to the control device, the other end of the analog-to-digital conversion unit is connected to the switch, and the switch is provided with a channel connected to the working electrode and a channel connected to the auxiliary electrode, wherein, The control device is further configured to collect the actual voltage value of the working electrode through the analog-to-digital conversion unit when the connection channel between the switch and the working electrode is turned on; When the connection channel between the switch and the auxiliary electrode is turned on, the actual voltage value of the auxiliary electrode is collected through the analog-to-digital conversion unit.

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