Continuous blood glucose monitoring device control method, device and equipment

Abstract

The present disclosure relates to a method, apparatus, and device for controlling a continuous blood glucose monitoring device, wherein the continuous blood glucose monitoring device includes an electrochemical sensor, and the method includes: loading corresponding bias voltages onto a working electrode and an auxiliary electrode of the electrochemical sensor, respectively, wherein the voltage difference between the bias voltage loaded onto the working electrode and the bias voltage loaded onto the auxiliary electrode is a first voltage difference, and the first voltage difference is the voltage difference required when the substance participating in the electrochemical reaction in the electrochemical sensor is glucose; detecting an actual voltage value of the working electrode and an actual voltage value of the auxiliary electrode; determining a second voltage difference based on the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode; and adjusting the bias voltage loaded onto the auxiliary electrode when the absolute value of the difference between the first voltage difference and the second voltage difference is greater than a preset threshold value, so that the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to the preset threshold value.

Description

Technical Field

[0001] The present disclosure relates to blood glucose monitoring technology, and more particularly, to a method, apparatus, and device for controlling a continuous blood glucose monitoring device. Background Art

[0002] In a continuous glucose monitoring (CGM) device, glucose in the tissue fluid undergoes an electrochemical reaction with the active substance on the electrochemical sensor to generate an electric current, based on which the concentration of glucose in the tissue fluid can be determined.

[0003] In addition to glucose, tissue fluid also contains a variety of electrochemically active substances, such as uric acid and ascorbic acid. These substances will also undergo electrochemical reactions on electrochemical sensors, generating interference signals and affecting the accuracy and stability of glucose measurement.

[0004] Therefore, it is necessary to provide a technical solution to suppress the reaction of interfering substances in tissue fluid and achieve noise reduction. Summary of the Invention

[0005] An object of the present invention is to provide a new technical solution for a method of controlling a continuous blood glucose monitoring device.

[0006] According to a first aspect of the present invention, a method for controlling a continuous blood glucose monitoring device is provided, wherein the continuous blood glucose monitoring device includes an electrochemical sensor, and the method comprises:

[0007] Applying corresponding bias voltages to a working electrode and an auxiliary electrode of the electrochemical sensor, respectively, wherein a voltage difference between the bias voltage applied to the working electrode and the bias voltage applied to the auxiliary electrode is a first voltage difference, and the first voltage difference is a voltage difference required when the substance participating in the electrochemical reaction in the electrochemical sensor is glucose;

[0008] Detecting and obtaining an actual voltage value of the working electrode and an actual voltage value of the auxiliary electrode;

[0009] determining a second voltage difference according to the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode;

[0010] When the absolute value of the difference between the first voltage difference and the second voltage difference is greater than a preset threshold, the bias voltage loaded on the auxiliary electrode is adjusted so that the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to the preset threshold.

[0011] Optionally, the bias voltage applied to the working electrode is a voltage required for glucose to produce an electrochemical reaction in the electrochemical sensor.

[0012] Optionally, adjusting the bias voltage applied to the auxiliary electrode so that the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to the preset threshold value includes:

[0013] When the second voltage difference is greater than the first voltage difference, increasing the bias voltage applied to the auxiliary electrode;

[0014] When the second voltage difference is smaller than the first voltage difference, the bias voltage applied to the auxiliary electrode is lowered.

[0015] Optionally, adjusting the bias voltage applied to the auxiliary electrode so that the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to the preset threshold value includes:

[0016] adjusting a bias voltage applied to the auxiliary electrode based on a preset voltage step;

[0017] Re-detecting and obtaining the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode;

[0018] determining a new second voltage difference based on the actual voltage value of the working electrode obtained by retesting and the actual voltage value of the auxiliary electrode obtained by retesting;

[0019] When the absolute value of the difference between the first voltage difference and the new second voltage difference is greater than a preset threshold, continue to adjust the bias voltage loaded to the auxiliary electrode based on the preset voltage step until the absolute value of the difference between the first voltage difference and the determined new second voltage difference is less than or equal to the preset threshold.

[0020] Optionally, the continuous blood glucose monitoring device further includes an analog-to-digital conversion unit and a switch, wherein the analog-to-digital conversion unit is connected to the switch, and the switch is provided with a channel connected to the working electrode and a channel connected to the auxiliary electrode, wherein:

[0021] The detecting the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode to determine the second voltage difference includes:

[0022] When the connection channel between the switch and the working electrode is connected, the actual voltage value of the working electrode is collected by the analog-to-digital conversion unit;

[0023] When the connection channel between the switch and the auxiliary electrode is turned on, the actual voltage value of the auxiliary electrode is collected by the analog-to-digital conversion unit.

[0024] Optionally, the continuous blood glucose monitoring device further includes an extraction electrode, wherein:

[0025] When the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to the preset threshold, the method further includes:

[0026] obtaining a current generated by the electrochemical reaction based on an electrochemical reaction in the electrochemical sensor caused by the tissue fluid extracted by the extraction electrode;

[0027] The concentration of glucose in the tissue fluid is determined based on the current generated by the electrochemical reaction.

[0028] According to a second aspect of the present invention, there is provided a continuous blood glucose monitoring device control apparatus, comprising:

[0029] a voltage loading module, configured to load corresponding bias voltages to a working electrode and an auxiliary electrode of an electrochemical sensor in a continuous blood glucose monitoring device, respectively, wherein the voltage difference between the bias voltage loaded to the working electrode and the bias voltage loaded to the auxiliary electrode is a first voltage difference, which is the voltage difference required when the substance participating in the electrochemical reaction in the electrochemical sensor is glucose;

[0030] A voltage detection module, used to detect and obtain the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode;

[0031] a voltage difference determining module, configured to determine a second voltage difference according to an actual voltage value of the working electrode and an actual voltage value of the auxiliary electrode;

[0032] An adjustment module is used to adjust the bias voltage loaded to the auxiliary electrode when the absolute value of the difference between the first voltage difference and the second voltage difference is greater than a preset threshold, so that the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to the preset threshold.

[0033] According to a third aspect of the present invention, a continuous blood glucose monitoring device control apparatus is provided, comprising a memory and a processor, wherein the memory stores a computer program, and the computer program is used to control the processor to operate to execute the method according to any one of the first aspects.

[0034] According to a fourth aspect of the present invention, a continuous blood glucose monitoring device is provided, comprising: a control device, an AFE unit and an electrochemical sensor as described in the second aspect or the third aspect, wherein the control device is connected to the AFE unit, and the three electrodes in the electrochemical sensor are all connected to the AFE unit, and the three electrodes include a working electrode, a reference electrode and an auxiliary electrode.

[0035] Optionally, the device further includes an analog-to-digital conversion unit and a switch, wherein one end of the analog-to-digital conversion unit is connected to the control device, and the other end of the analog-to-digital conversion unit is connected to the switch, and the switch is provided with a channel connected to the working electrode and a channel connected to the auxiliary electrode, wherein:

[0036] The control device is further configured to collect the actual voltage value of the working electrode through the analog-to-digital conversion unit when the connection channel between the switch and the working electrode is connected;

[0037] When the connection channel between the switch and the auxiliary electrode is turned on, the actual voltage value of the auxiliary electrode is collected by the analog-to-digital conversion unit.

[0038] The control method provided by the present invention accurately controls the voltage difference between the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode, so that the voltage difference between the two is suitable for the substance participating in the electrochemical reaction in the electrochemical sensor is glucose, and inhibits other substances in the tissue fluid from participating in the electrochemical reaction, thereby improving the accuracy and reliability of the measurement of glucose concentration in the tissue fluid. In addition, the control method provided by the embodiment of the present invention is real-time feedback control, so that the continuous blood glucose monitoring equipment can operate stably under different environmental conditions, thereby improving the reliability of the equipment and user experience.

[0039] Features and advantages of the embodiments of the present specification will become apparent from the following detailed description of exemplary embodiments of the present specification with reference to the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0040] The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments of the specification and, together with the description, serve to explain the principles of the embodiments of the specification.

[0041] Figure 1 FIG. 4 is a flow chart of a method for controlling a continuous blood glucose monitoring device according to an embodiment of the present invention.

[0042] Figure 2 FIG. 4 is a schematic block diagram of a control device for a continuous blood glucose monitoring device according to an embodiment of the present invention.

[0043] Figure 3 FIG. 1 is a schematic structural diagram of a continuous blood glucose monitoring device control apparatus according to an embodiment of the present invention.

[0044] Figure 4 FIG. 4 is a schematic structural diagram of a continuous blood glucose monitoring device according to an embodiment of the present invention.

[0045] Figure 5 FIG. 4 is a schematic structural diagram of a continuous blood glucose monitoring device according to an embodiment of the present invention. DETAILED DESCRIPTION

[0046] Various exemplary embodiments of the present specification will now be described in detail with reference to the accompanying drawings.

[0047] The following description of at least one exemplary embodiment is merely illustrative in nature and is in no way intended to limit the embodiments of this specification, its application, or uses.

[0048] It should be noted that like reference numerals and letters refer to like items in the following figures, and therefore, once an item is defined in one figure, it need not be further discussed in subsequent figures.

[0049] In one embodiment of the present invention, a method for controlling a continuous blood glucose monitoring device is provided, and the method is applied to the continuous blood glucose monitoring device.

[0050] Continuous glucose monitoring devices include an electrochemical sensor. This electrochemical sensor has three electrodes: a working electrode (WE), a reference electrode (RE), and a counter electrode (CE). Glucose in tissue fluid reacts electrochemically with the enzyme in the electrochemical sensor, generating an electric current. The current generated by the electrochemical reaction is used to determine the glucose concentration in the tissue fluid.

[0051] according to Figure 1 As shown, the continuous blood glucose monitoring device control method of this embodiment includes the following steps S110 to S140.

[0052] In step S110, corresponding bias voltages are applied to the working electrode and the auxiliary electrode of the electrochemical sensor, respectively. The voltage difference between the bias voltage applied to the working electrode and the bias voltage applied to the auxiliary electrode is a first voltage difference, which is the voltage difference required when the substance involved in the electrochemical reaction in the electrochemical sensor is glucose.

[0053] The bias voltage applied to the working electrode of the electrochemical sensor and the bias voltage applied to the auxiliary electrode of the electrochemical sensor are both pre-stored values ​​and can be directly obtained.

[0054] The bias voltage applied to the working electrode determines the intensity of the electrochemical reaction of glucose in the electrochemical sensor. In this embodiment, the bias voltage applied to the working electrode is the voltage required to generate the electrochemical reaction of glucose in the electrochemical sensor.

[0055] The voltage difference between the bias voltage applied to the working electrode and the bias voltage applied to the auxiliary electrode determines the type of substance in the tissue fluid that participates in the electrochemical reaction. In this embodiment, the first voltage difference is the voltage difference required when the only substance participating in the electrochemical reaction in the electrochemical sensor is glucose. This first voltage difference can inhibit other substances in the tissue fluid from participating in the electrochemical reaction.

[0056] Step S120 , detecting and obtaining the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode.

[0057] Due to the influence of its structure and external environment, the actual voltage value of the working electrode is different from the bias voltage applied to the working electrode, and the actual voltage value of the auxiliary electrode is different from the bias voltage applied to the auxiliary electrode. Therefore, it is necessary to detect the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode.

[0058] In some embodiments, the continuous blood glucose monitoring device further includes an analog-to-digital conversion unit and a switch, the analog-to-digital conversion unit is connected to the switch, and the switch is provided with a channel connected to the working electrode and a channel connected to the auxiliary electrode.

[0059] Step S120 specifically includes: when the connection channel between the switch and the working electrode is turned on, collecting the actual voltage value of the working electrode through the analog-to-digital conversion unit; when the connection channel between the switch and the auxiliary electrode is turned on, collecting the actual voltage value of the auxiliary electrode through the analog-to-digital conversion unit.

[0060] In this embodiment, the combination of the analog-to-digital conversion unit and the switch can realize the collection and switching of multi-channel voltage signals. The collection of voltage values ​​of multiple electrodes shares the same analog-to-digital conversion unit, reducing hardware complexity and cost.

[0061] Step S130: determining a second voltage difference according to the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode.

[0062] In step S140 , when the absolute value of the difference between the first voltage difference and the second voltage difference is greater than a preset threshold, the bias voltage applied to the auxiliary electrode is adjusted so that the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to the preset threshold.

[0063] When the absolute value of the difference between the first voltage difference and the second voltage difference is greater than a preset threshold, it is determined that the voltage difference between the current actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode is not suitable for glucose to participate in the electrochemical reaction, which may cause other substances in the tissue fluid to participate in the electrochemical reaction. In addition, because the bias voltage applied to the working electrode determines the intensity of the electrochemical reaction produced by glucose in the electrochemical sensor, in order not to affect the electrochemical reaction produced by glucose in the electrochemical sensor, after the corresponding bias voltage is applied to the working electrode, the bias voltage applied to the working electrode is no longer adjusted. Instead, the bias voltage applied to the auxiliary electrode is adjusted so that the voltage difference between the current actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode is suitable for glucose to participate in the electrochemical reaction.

[0064] When the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to a preset threshold, it is determined that the voltage difference between the actual voltage value of the current working electrode and the actual voltage value of the auxiliary electrode is suitable for glucose to participate in the electrochemical reaction, while inhibiting other substances in the tissue fluid from participating in the electrochemical reaction.

[0065] In some embodiments, adjusting the bias voltage loaded to the auxiliary electrode so that the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to a preset threshold value specifically includes: when the second voltage difference is greater than the first voltage difference, increasing the bias voltage loaded to the auxiliary electrode; when the second voltage difference is less than the first voltage difference, decreasing the bias voltage loaded to the auxiliary electrode.

[0066] When the second voltage difference is greater than the first voltage difference, the bias voltage loaded on the auxiliary electrode is increased so that the actual voltage value of the auxiliary electrode detected becomes larger, thereby reducing the voltage difference between the actual voltage value of the current working electrode and the actual voltage value of the auxiliary electrode, so as to be suitable for glucose to participate in the electrochemical reaction.

[0067] When the second voltage difference is smaller than the first voltage difference, the bias voltage loaded on the auxiliary electrode is lowered so that the actual voltage value of the auxiliary electrode detected becomes smaller, thereby increasing the voltage difference between the actual voltage value of the current working electrode and the actual voltage value of the auxiliary electrode, so as to be suitable for glucose to participate in the electrochemical reaction.

[0068] In some embodiments, adjusting the bias voltage loaded to the auxiliary electrode so that the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to a preset threshold specifically includes: adjusting the bias voltage loaded to the auxiliary electrode based on a preset voltage step; re-detecting the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode; determining a new second voltage difference based on the re-detected actual voltage value of the working electrode and the re-detected actual voltage value of the auxiliary electrode; when the absolute value of the difference between the first voltage difference and the new second voltage difference is greater than the preset threshold, continuing to adjust the bias voltage loaded to the auxiliary electrode based on the preset voltage step until the absolute value of the difference between the first voltage difference and the determined new second voltage difference is less than or equal to the preset threshold.

[0069] If the second voltage difference is greater than the first voltage difference, the bias voltage applied to the auxiliary electrode is increased based on a preset voltage step size, and the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode are re-detected. A new second voltage difference is determined based on the re-detected actual voltage value of the working electrode and the re-detected actual voltage value of the auxiliary electrode. If the absolute value of the difference between the first voltage difference and the new second voltage difference is greater than a preset threshold, the bias voltage applied to the auxiliary electrode is continued to be increased based on the preset voltage step size until the absolute value of the difference between the first voltage difference and the determined second voltage difference is less than or equal to the preset threshold.

[0070] If the second voltage difference is less than the first voltage difference, the bias voltage applied to the auxiliary electrode is lowered based on a preset voltage step size, and the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode are re-detected. A new second voltage difference is determined based on the re-detected actual voltage value of the working electrode and the re-detected actual voltage value of the auxiliary electrode. If the absolute value of the difference between the first voltage difference and the new second voltage difference is greater than a preset threshold, the bias voltage applied to the auxiliary electrode is further lowered based on the preset voltage step size until the absolute value of the difference between the first voltage difference and the determined second voltage difference is less than or equal to the preset threshold.

[0071] By gradually adjusting the bias voltage of the auxiliary electrode by presetting the voltage step, the potential difference between the working electrode and the auxiliary electrode can be accurately controlled, which can avoid the problem of over-adjustment during the voltage adjustment process and improve the stability of the voltage adjustment.

[0072] In some embodiments, the continuous glucose monitoring device further includes an extraction electrode. When the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to a preset threshold, the method further includes: obtaining a current generated by an electrochemical reaction in the electrochemical sensor based on an electrochemical reaction of the tissue fluid extracted by the extraction electrode; and determining the glucose concentration in the tissue fluid based on the current generated by the electrochemical reaction.

[0073] Continuous glucose monitoring devices also include an AFE (Active Front End) unit, to which the working electrode, reference electrode, and auxiliary electrode in the electrochemical sensor are connected.

[0074] Glucose in the tissue fluid extracted by the extraction electrode can undergo an electrochemical reaction with the reaction enzyme in the electrochemical sensor. Under the electrochemical action, the reference electrode RE and the auxiliary electrode CE in the electrochemical sensor are short-circuited, forming the electrode RCE. The current generated by the electrochemical reaction in the electrochemical sensor flows out through the working electrode of the electrochemical sensor, flows through the feedback resistor in the AFE unit, and then flows into the electrode RCE of the electrochemical sensor. First, the voltage value across the feedback resistor is determined. Based on the voltage value across the feedback resistor and the structure of the feedback resistor, the current generated by the electrochemical reaction in the electrochemical sensor is calculated.

[0075] The control method provided in the embodiment of the present invention accurately controls the voltage difference between the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode, so that the voltage difference between the two is suitable for the substance participating in the electrochemical reaction in the electrochemical sensor is glucose, and inhibits other substances in the tissue fluid from participating in the electrochemical reaction, thereby improving the accuracy and reliability of the measurement of glucose concentration in the tissue fluid. In addition, the control method provided in the embodiment of the present invention is real-time feedback control, so that the continuous blood glucose monitoring device can operate stably under different environmental conditions, thereby improving the reliability of the device and user experience.

[0076] One embodiment of the present invention provides a continuous blood glucose monitoring device control device. Figure 2 As shown, the continuous glucose monitoring device control apparatus 200 includes a voltage loading module 210 , a voltage monitoring module 220 , a voltage difference determining module 230 and an adjusting module 240 .

[0077] The voltage loading module 210 is used to load corresponding bias voltages to the working electrode and the auxiliary electrode of the electrochemical sensor in the continuous blood glucose monitoring device, respectively. The voltage difference between the bias voltage loaded to the working electrode and the bias voltage loaded to the auxiliary electrode is a first voltage difference, which is the voltage difference required when the substance participating in the electrochemical reaction in the electrochemical sensor is glucose.

[0078] The voltage detection module 220 is used to detect and obtain the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode.

[0079] The voltage difference determination module 230 is configured to determine a second voltage difference according to an actual voltage value of the working electrode and an actual voltage value of the auxiliary electrode.

[0080] The adjustment module 240 is used to adjust the bias voltage applied to the auxiliary electrode when the absolute value of the difference between the first voltage difference and the second voltage difference is greater than the preset threshold, so that the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to the preset threshold.

[0081] In some embodiments, the bias voltage applied to the working electrode is a voltage required to generate an electrochemical reaction of glucose in the electrochemical sensor.

[0082] In some embodiments, the adjustment module 240 is further configured to increase the bias voltage applied to the auxiliary electrode when the second voltage difference is greater than the first voltage difference, and to decrease the bias voltage applied to the auxiliary electrode when the second voltage difference is less than the first voltage difference.

[0083] In some embodiments, the adjustment module 240 is also used to adjust the bias voltage loaded to the auxiliary electrode based on a preset voltage step; re-detect and obtain the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode; determine a new second voltage difference based on the re-detected actual voltage value of the working electrode and the re-detected actual voltage value of the auxiliary electrode; when the absolute value of the difference between the first voltage difference and the new second voltage difference is greater than a preset threshold, continue to adjust the bias voltage loaded to the auxiliary electrode based on the preset voltage step until the absolute value of the difference between the first voltage difference and the determined new second voltage difference is less than or equal to the preset threshold.

[0084] In some embodiments, the continuous glucose monitoring device further includes an analog-to-digital conversion unit and a switch, wherein the analog-to-digital conversion unit is connected to the switch, and the switch is provided with a channel connected to the working electrode and a channel connected to the auxiliary electrode. The voltage detection module 220 is further configured to collect the actual voltage value of the working electrode through the analog-to-digital conversion unit when the connection channel between the switch and the working electrode is connected;

[0085] When the connection channel between the switch and the auxiliary electrode is turned on, the actual voltage value of the auxiliary electrode is collected by the analog-to-digital conversion unit.

[0086] In some embodiments, the continuous glucose monitoring device further includes an extraction electrode. The device further includes a glucose concentration measurement module. The glucose concentration measurement module is configured to, when the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to a preset threshold, obtain a current generated by the electrochemical reaction in the electrochemical sensor based on the tissue fluid extracted by the extraction electrode; and determine the glucose concentration in the tissue fluid based on the current generated by the electrochemical reaction.

[0087] The control device of the continuous blood glucose monitoring device is an MCU (Microcontroller Unit).

[0088] One embodiment of the present invention provides a continuous blood glucose monitoring device control device. Figure 3 As shown, the continuous glucose monitoring device control apparatus 300 includes a memory 320 and a processor 310. The memory 320 stores a computer program, which is used to control the processor 310 to operate so as to execute the control method provided according to any of the above embodiments.

[0089] One embodiment of the present invention provides a continuous blood glucose monitoring device. Figure 4 As shown, the continuous glucose monitoring device includes a control device, an AFE unit, and an electrochemical sensor according to any of the above embodiments. The control device is connected to the AFE unit. The three electrodes in the electrochemical sensor are all connected to the AFE unit. The three electrodes include a working electrode, a reference electrode, and an auxiliary electrode.

[0090] The control device applies corresponding bias voltages to the working electrode and the auxiliary electrode of the electrochemical sensor through the AFE unit.

[0091] The working electrode, reference electrode, and auxiliary electrode in the electrochemical sensor are all connected to the AFE unit. Glucose in the tissue fluid extracted by the extraction electrode undergoes an electrochemical reaction with the enzyme in the electrochemical sensor. Under electrochemical action, the reference electrode RE and the auxiliary electrode CE in the electrochemical sensor are short-circuited, forming the electrode RCE. The current generated by the electrochemical reaction in the electrochemical sensor flows out through the working electrode, flows through the feedback resistor in the AFE unit, and then flows into the electrochemical sensor electrode RCE.

[0092] according to Figure 5 As shown, the continuous glucose monitoring device also includes an analog-to-digital conversion unit and a switch. One end of the analog-to-digital conversion unit is connected to the control device, and the other end of the analog-to-digital conversion unit is connected to the switch. The switch is provided with a channel connected to the working electrode and a channel connected to the auxiliary electrode.

[0093] The control device is also used to collect the actual voltage value of the working electrode through the analog-to-digital conversion unit when the connection channel between the switch and the working electrode is connected; and to collect the actual voltage value of the auxiliary electrode through the analog-to-digital conversion unit when the connection channel between the switch and the auxiliary electrode is connected.

[0094] according to Figure 5As shown, the control device is also connected to the switch. The control device controls the connection channel between the switch and the working electrode or the connection channel between the switch and the auxiliary electrode by controlling the level of the interface connected to the switch. For example, when the control device controls the level of the interface connected to the switch to be high, the control device controls the connection channel between the switch and the auxiliary electrode, that is, the AC channel is connected. When the control device controls the level of the interface connected to the switch to be low, the control device controls the connection channel between the switch and the working electrode, that is, the BC channel is connected. It should be noted that under electrochemical action, the reference electrode RE and the auxiliary electrode CE in the electrochemical sensor are short-circuited to form an electrode RCE. Therefore, the actual voltage values ​​corresponding to the reference electrode RE and the auxiliary electrode CE are the same voltage value.

[0095] according to Figure 5 The continuous glucose monitoring device further includes a DC-DC unit and an extraction electrode. One end of the DC-DC unit is connected to a control device, and the other end of the DC-DC unit is connected to the extraction electrode. The control device is used to control the extraction electrode to extract tissue fluid through the DC-DC unit.

[0096] The various embodiments in this specification are described in a progressive manner, and the same or similar parts between the various embodiments can be referred to each other. Each embodiment focuses on the differences from other embodiments.

[0097] The foregoing description of this specification describes specific embodiments. Other embodiments are within the scope of the appended claims. In some cases, the actions or steps recited in the claims can be performed in an order different from that described in the embodiments and still achieve the desired results. Furthermore, the processes depicted in the accompanying drawings do not necessarily require the specific order shown or the sequential order to achieve the desired results. In certain embodiments, multitasking and parallel processing are also possible or may be advantageous.

[0098] The embodiments of this specification may be systems, methods, and / or computer program products. The computer program product may include a computer-readable storage medium carrying computer instructions for causing a processor to implement various aspects of the embodiments of this specification.

[0099] A computer-readable storage medium can be a tangible device that can retain and store computer instructions for use by a computer instruction execution device. A computer-readable storage medium can be, for example, but not limited to, an electrical storage device, a magnetic storage device, an optical storage device, an electromagnetic storage device, a semiconductor storage device, or any suitable combination thereof. More specific examples (a non-exhaustive list) of computer-readable storage media include: a portable computer disk, a hard disk, random access memory (RAM), read-only memory (ROM), erasable programmable read-only memory (EPROM or flash memory), static random access memory (SRAM), a portable compact disc read-only memory (CD-ROM), a digital versatile disk (DVD), a memory stick, a floppy disk, a mechanical encoding device, such as a punched card or raised-in-groove structure on which computer instructions are stored, and any suitable combination thereof. As used herein, a computer-readable storage medium is not to be construed as a transient signal per se, such as a radio wave or other freely propagating electromagnetic wave, an electromagnetic wave propagating through a waveguide or other transmission medium (e.g., a light pulse through a fiber-optic cable), or an electrical signal transmitted through an electrical wire.

[0100] The computer instructions described herein can be downloaded from a computer-readable storage medium to each computing / processing device, or downloaded to an external computer or external storage device via a network, such as the Internet, a local area network, a wide area network, and / or a wireless network. The network can include copper transmission cables, fiber optic transmission, wireless transmission, routers, firewalls, switches, gateway computers, and / or edge servers. The network adapter card or network interface in each computing / processing device receives the computer instructions from the network and forwards the computer instructions to be stored in the computer-readable storage medium in each computing / processing device.

[0101] The flowcharts and block diagrams in the accompanying drawings show the possible implementation architectures, functions and operations of the systems, methods and computer program products according to multiple embodiments of this specification. In this regard, each box in the flowchart or block diagram can represent a module, program segment or part of a computer instruction, and the module, program segment or part of a computer instruction contains one or more executable computer instructions for implementing the specified logical function. In some alternative implementations, the functions marked in the box can also occur in an order different from that marked in the accompanying drawings. For example, two consecutive boxes can actually be executed substantially in parallel, and they can sometimes be executed in the opposite order, depending on the functions involved. It should also be noted that each box in the block diagram and / or flowchart, and the combination of boxes in the block diagram and / or flowchart, can be implemented using a dedicated hardware-based system that performs the specified function or action, or can be implemented using a combination of dedicated hardware and computer instructions. It is well known to those skilled in the art that implementation by hardware, implementation by software, and implementation by a combination of software and hardware are all equivalent.

[0102] The embodiments of the present specification have been described above. The above description is illustrative and not exhaustive, and is not limited to the disclosed embodiments. Many modifications and variations will be apparent to those skilled in the art without departing from the scope of the described embodiments. The terminology used herein is selected to best explain the principles of the embodiments, their practical applications, or improvements to existing technologies, or to enable others skilled in the art to understand the embodiments disclosed herein.

Claims

1. A method for controlling a continuous blood glucose monitoring device, characterized in that: The continuous glucose monitoring device includes an electrochemical sensor, and the method includes: Applying corresponding bias voltages to a working electrode and an auxiliary electrode of the electrochemical sensor, respectively, wherein a voltage difference between the bias voltage applied to the working electrode and the bias voltage applied to the auxiliary electrode is a first voltage difference, and the first voltage difference is a voltage difference required when the substance participating in the electrochemical reaction in the electrochemical sensor is glucose; Detecting and obtaining an actual voltage value of the working electrode and an actual voltage value of the auxiliary electrode; determining a second voltage difference according to the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode; When the absolute value of the difference between the first voltage difference and the second voltage difference is greater than a preset threshold, the bias voltage loaded on the auxiliary electrode is adjusted so that the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to the preset threshold.

2. The method according to claim 1, characterized in that The bias voltage applied to the working electrode is a voltage required for glucose to generate an electrochemical reaction in the electrochemical sensor.

3. The method according to claim 1, characterized in that The adjusting the bias voltage applied to the auxiliary electrode so that the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to the preset threshold value includes: When the second voltage difference is greater than the first voltage difference, increasing the bias voltage applied to the auxiliary electrode; When the second voltage difference is smaller than the first voltage difference, the bias voltage applied to the auxiliary electrode is lowered.

4. The method according to claim 1, wherein The adjusting the bias voltage applied to the auxiliary electrode so that the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to the preset threshold value includes: adjusting a bias voltage applied to the auxiliary electrode based on a preset voltage step; Re-detecting and obtaining the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode; determining a new second voltage difference based on the actual voltage value of the working electrode obtained by retesting and the actual voltage value of the auxiliary electrode obtained by retesting; When the absolute value of the difference between the first voltage difference and the new second voltage difference is greater than a preset threshold, continue to adjust the bias voltage loaded to the auxiliary electrode based on the preset voltage step until the absolute value of the difference between the first voltage difference and the determined new second voltage difference is less than or equal to the preset threshold.

5. The method according to claim 1, wherein The continuous blood glucose monitoring device further includes an analog-to-digital conversion unit and a switch, wherein the analog-to-digital conversion unit is connected to the switch, and the switch is provided with a channel connected to the working electrode and a channel connected to the auxiliary electrode, wherein: The detecting the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode to determine the second voltage difference includes: When the connection channel between the switch and the working electrode is connected, the actual voltage value of the working electrode is collected by the analog-to-digital conversion unit; When the connection channel between the switch and the auxiliary electrode is turned on, the actual voltage value of the auxiliary electrode is collected by the analog-to-digital conversion unit.

6. The method according to any one of claims 1 to 5, characterized in that: The continuous blood glucose monitoring device further comprises an extraction electrode, wherein When the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to the preset threshold, the method further includes: obtaining a current generated by the electrochemical reaction based on an electrochemical reaction in the electrochemical sensor caused by the tissue fluid extracted by the extraction electrode; The concentration of glucose in the tissue fluid is determined based on the current generated by the electrochemical reaction.

7. A continuous blood glucose monitoring device control device, characterized in that: include: a voltage loading module, configured to load corresponding bias voltages to a working electrode and an auxiliary electrode of an electrochemical sensor in a continuous blood glucose monitoring device, respectively, wherein the voltage difference between the bias voltage loaded to the working electrode and the bias voltage loaded to the auxiliary electrode is a first voltage difference, which is the voltage difference required when the substance participating in the electrochemical reaction in the electrochemical sensor is glucose; A voltage detection module, used to detect and obtain the actual voltage value of the working electrode and the actual voltage value of the auxiliary electrode; a voltage difference determining module, configured to determine a second voltage difference according to an actual voltage value of the working electrode and an actual voltage value of the auxiliary electrode; An adjustment module is used to adjust the bias voltage loaded to the auxiliary electrode when the absolute value of the difference between the first voltage difference and the second voltage difference is greater than a preset threshold, so that the absolute value of the difference between the first voltage difference and the second voltage difference is less than or equal to the preset threshold.

8. A continuous blood glucose monitoring device control device, characterized in that: The method comprises a memory and a processor, wherein the memory stores a computer program, and the computer program is used to control the processor to operate so as to perform the method according to any one of claims 1 to 6.

9. A continuous blood glucose monitoring device, characterized in that: include: The control device, AFE unit, and electrochemical sensor according to claim 7 or 8, wherein the control device is connected to the AFE unit, and the three electrodes in the electrochemical sensor are all connected to the AFE unit, and the three electrodes include a working electrode, a reference electrode, and an auxiliary electrode.

10. The continuous blood glucose monitoring device according to claim 9, characterized in that The device further includes an analog-to-digital conversion unit and a switch, wherein one end of the analog-to-digital conversion unit is connected to the control device, and the other end of the analog-to-digital conversion unit is connected to the switch, and the switch is provided with a channel connected to the working electrode and a channel connected to the auxiliary electrode, wherein: The control device is further configured to collect the actual voltage value of the working electrode through the analog-to-digital conversion unit when the connection channel between the switch and the working electrode is connected; When the connection channel between the switch and the auxiliary electrode is turned on, the actual voltage value of the auxiliary electrode is collected by the analog-to-digital conversion unit.

Images