Preparation method of premix for enhancing laying hen production treatment

Abstract

The invention relates to a livestock breeding technology, and discloses a preparation method of a premix for enhancing laying hen production treatment, in the construction of a basic nutrition framework, the construction of a vitamin system is a core project, vitamin A is supplemented by adopting a palmitate form, the stability of the vitamin A in feed processing is ensured, the level of 8000-12000IU should be maintained in each kilogram of feed, and the content of the vitamin A in the feed processing is reduced. According to the fallopian tube mucous membrane composition, the addition amount of the vitamin D3 in the metabolic activity form of 25-hydroxyD3 needs to reach 2000-3000 IU / kg, the vitamin D3 and parathyroid hormone have a synergistic effect, the calcium and phosphorus deposition efficiency can be remarkably improved, particularly, the synergistic effect of B vitamins is worthy of attention, and thiamine (B1) and riboflavin (B2) are compatible according to the proportion of 1: 2. According to the preparation method of the premix for enhancing laying hen production treatment, the growth speed and the laying efficiency of chicken flocks are effectively improved, the eggshell quality is ensured, nutritional diseases such as chondropathy and egg reduction diseases are reduced, and the economic benefits of laying hen breeding are greatly improved.

Description

Technical Field

[0001] The invention relates to the technical field of animal husbandry, and in particular to a method for preparing a premix for enhanced laying hen production and processing. Background Art

[0002] In the early stages of the development of the breeding industry, laying hens mainly relied on traditional grains such as corn and wheat bran as feed. Under this breeding model, the chickens grew slowly, had low egg production efficiency, and were prone to nutritional diseases such as rickets and reduced egg production. With the continuous advancement of modern breeding, scientists have gradually realized that the nutritional needs of laying hens are both complex and sophisticated, and basic feed alone is far from enough to meet them.

[0003] In addition, with the vigorous development of modern laying hen farming industry, the market has put forward higher requirements for the output and quality of eggs. Under the traditional laying hen farming model, the feed nutrients are single and lack precise control of vitamins and mineral elements, which cannot meet the complex nutritional needs of laying hens. Chickens often suffer from nutritional imbalance, damaged oviduct health, poor eggshell quality, and difficulty in improving egg production performance, which limits the growth of farming benefits. There is an urgent need for a premix preparation method that can comprehensively improve the production performance of laying hens.

[0004] At the same time, with the continuous expansion of the scale of laying hen farming, the breeding area is becoming increasingly wide, the environment in different regions is significantly different, and the quality and composition of feed raw materials fluctuate greatly. Traditional premix formulas are difficult to adapt to such diverse changes and lack a dynamic adjustment mechanism, resulting in a disconnect between nutritional supply and the actual needs of laying hens. In terms of formula optimization, traditional methods are inefficient and costly, and cannot achieve accurate nutritional supply. Against this background, it is urgent to develop a set of premix preparation methods that can be flexibly adjusted according to regional differences and raw material changes, and use advanced technology to achieve efficient formula optimization. Therefore, the practice of adding specific trace elements, vitamins and other ingredients to basic feed began to appear. This measure made up for the shortcomings of basic feed, and laying hen premixes came into being. Summary of the Invention

[0005] (1) Technical problems solved

[0006] In response to the shortcomings of the existing technology, the present invention provides a method for preparing a premix for enhanced laying hen production and processing, which has the advantages of improving egg production efficiency and improving breeding economic benefits, and solves the problems of poor eggshell quality and difficulty in improving egg production performance.

[0007] (2) Technical solution

[0008] In order to achieve the above-mentioned purpose of high egg production efficiency and improved economic benefits of breeding, the present invention provides the following technical solution: a method for preparing a premix for enhanced laying hen production and processing, comprising the following steps:

[0009] S1. Construction of precise nutritional composition ratio

[0010] In establishing a basic nutritional framework, the construction of a vitamin system is a core project. Vitamin A is supplemented in the form of palmitate to ensure its stability during feed processing. A level of 8,000-12,000 IU per kilogram of feed should be maintained to ensure the integrity of the fallopian tube mucosa and the health of the visual system. The addition of 25-hydroxy D3, the metabolically active form of vitamin D3, needs to reach 2,000-3,000 IU / kg. It works synergistically with parathyroid hormone to significantly improve the efficiency of calcium and phosphorus deposition. Of particular note is the synergistic effect of B vitamins. Thiamine (B1) and riboflavin (B2) in a 1:2 ratio can increase carbohydrate metabolism efficiency by 15-20%, while the molecular docking of cobalamin (B12) and folic acid can increase the efficiency of methionine synthesis by more than 30%.

[0011] In terms of mineral balance, the use of amino acid chelated trace elements can increase bioavailability by 40%. Iron is added in the form of ferrous glycine, which prevents anemia and improves eggshell color. The molar ratio of magnesium ions to potassium ions is controlled at 1:3, which effectively maintains stable cellular osmotic pressure. In the calcium-phosphorus dynamic balance system, the available phosphorus level must reach 0.38-0.42%. By using a 7:3 ratio of calcium hydrogen phosphate to shell powder, the eggshell thickness can be increased to over 0.38mm, and the egg breakage rate can be reduced by 2-3 percentage points.

[0012] S2. Targeted Regulation of Functional Additives

[0013] The antioxidant defense system is constructed using a gradient antioxidant strategy: Vitamin E, a fat-soluble antioxidant, blocks lipid peroxidation chain reactions at a level of 50-80 mg / kg. Selenium is added in the form of yeast selenium to form glutathione peroxidase in the liver, which is 2.4 times more efficient at scavenging free radicals than inorganic selenium. Tea polyphenols, as natural antioxidants, can simultaneously scavenge water-soluble and fat-soluble free radicals, forming a synergistic antioxidant network.

[0014] Intestinal health management adopts a "three-dimensional regulation" model: Bacillus subtilis (1×10^8 CFU / g) inhibits the proliferation of harmful bacteria by secreting lipopeptides. A complex enzyme system of xylanase and β-glucanase degrades non-starch polysaccharides, releasing encapsulated nutrients. Mannan oligosaccharides adsorb intestinal pathogens and reduce their colonization ability. The synergistic effect of these three can increase feed conversion rate by 8-10% and reduce diarrhea rate by more than 50%.

[0015] The immune enhancement system uses a dual activation mechanism: yeast cell wall polysaccharides activate the phagocytic activity of macrophages, increasing serum IgG levels by 25%, while astragalus polysaccharides promote T lymphocyte proliferation and enhance cellular immune responses. Under heat stress conditions, this combined immune enhancer can maintain egg production at above 90%, an increase of 5-7 percentage points compared to the control group.

[0016] S3. System integration of special function modules

[0017] The high egg production rate control module is based on an ideal amino acid model. By optimizing the ratio of methionine to lysine (1.15:1) and maintaining a dynamic balance between threonine and tryptophan, it can extend the peak egg production period by 2-3 weeks. In terms of energy metabolism, the addition of medium-chain fatty acid glycerides can reduce liver ketone body production by 40%, ensuring stable ovarian function.

[0018] The eggshell quality optimization system uses nano-scale calcium carbonate particles (particle size <100nm), whose specific surface area is 5 times that of ordinary stone powder, which can increase calcium deposition efficiency by 35%. Combined with the synergistic effect of zinc and manganese elements, the eggshell strength can reach 3.8kg / cm 2 Above, the egg-shaped index is controlled in the ideal range of 1.30-1.35;

[0019] The production life extension project is achieved through a dual protective mechanism: the combination of vitamin C (200mg / kg) and betaine can reduce cortisol levels caused by heat stress by 28%. Silymarin, as a liver protectant, can increase liver glutathione peroxidase activity by 45%, effectively delaying liver cell aging. Practice has shown that this program can maintain the egg production rate of laying hens at 72 weeks of age at above 82%.

[0020] S4. Precision Nutrition Supply Program

[0021] In a 2% premix system, the recommended addition levels of core nutrients are: vitamin A 8000 IU / kg, vitamin D3 2500 IU / kg, vitamin E 60 mg / kg, selenium 0.3 mg / kg, methionine 0.15%, and threonine 0.08%. In actual application, dynamic adjustments need to be made based on the coefficient of variation of the raw materials. For example, when the moisture content of corn exceeds 14%, the metabolizable energy level needs to be deducted by 0.45 kcal / g, and the amino acid concentration should be adjusted accordingly.

[0022] Regional formulation adjustments follow the principle of "three factors": In high-altitude areas (>2000m), vitamin C needs to be increased to 300mg / kg to alleviate hypoxic stress. In hot and humid areas, adding 0.1% calcium propionate can inhibit mold growth. For diets using cottonseed meal, iron needs to be supplemented to 80mg / kg to antagonize gossypol toxicity.

[0023] S5. Dynamic Nutrition Management System

[0024] The effectiveness of the program was evaluated using a PDCA cycle: daily records of production indicators such as egg production rate, egg weight, and feed intake were recorded; weekly tests of egg quality parameters such as eggshell thickness and Haugh units were performed; and monthly serum biochemical indicators were analyzed. When egg production rate dropped by more than 2% for three consecutive days, a nutritional intervention program was initiated to rapidly restore production performance by adjusting the electrolyte balance (Na:K:Cl = 1:0.8:0.6) or supplementing with biotin (200 μg / kg).

[0025] Formula optimization uses response surface analysis to establish a multivariate regression model for egg production rate, eggshell strength, and feed conversion rate. Monte Carlo simulation technology can quickly determine the optimal formula combination for different production targets. Practice has shown that this system can shorten the premix formula adjustment cycle to 7 days and reduce formula costs by 3-5%.

[0026] In practical applications, it is recommended to use it in conjunction with an intelligent feeding system, monitor the raw material composition online through near-infrared spectroscopy, and combine the behavioral data of laying hens (such as feather pecking frequency and water drinking times) to achieve real-time dynamic optimization of nutritional supply. This intelligent nutritional management model can control the mortality rate of laying hens within 3% throughout the entire process and reduce the feed-to-egg ratio during the laying period to below 1.9:1.

[0027] Preferably, in step S1, 25-hydroxy D3 is highly photosensitivity, and the premix should be stored away from light. The actual amount added needs to be dynamically adjusted according to the storage time (increase the amount by 5% every 30 days of storage). The compatibility of B vitamins needs to pay attention to the influence of pH value. When the pH of the premix is lower than 5.5, the stability of thiamine will decrease by 20%. It is recommended to add 1% sodium bicarbonate for buffering and regulation.

[0028] Preferably, in step S1, the particle size distribution of the calcium source has a significant impact on the quality of the eggshell, and the shell powder should be controlled to have 40-60 mesh particles accounting for more than 70% to ensure the continuous release of calcium. When phytase is used, the effective phosphorus level can be reduced by 0.05%, but sodium needs to be supplemented simultaneously to maintain electrolyte balance.

[0029] Preferably, in step S2, in the construction of the antioxidant defense system, special attention should be paid to the synergistic enhancement threshold of each component. When the amount of tea polyphenols added exceeds 200 mg / kg, it may compete with vitamin E for absorption. It is recommended to achieve sustained release through lipid encapsulation technology. At the same time, the bioavailability of yeast selenium is significantly affected by storage conditions. After 6 months of storage in a high temperature and high humidity environment, the activity loss can reach 35%, and its effective content needs to be tested regularly.

[0030] Preferably, in step S2, the tempering temperature needs to be controlled not to exceed 85°C during the granulation process to ensure the survival rate of live bacteria. The dual activation mechanism of the immune enhancement system is dose-sensitive: when the amount of yeast cell wall polysaccharide added exceeds 1500 mg / kg, it may cause immunosuppression, and the optimal compatibility concentration of astragalus polysaccharide is 500-800 mg / kg. Under heat stress conditions, it is recommended to simultaneously supplement 0.3% potassium chloride and 0.2% sodium bicarbonate to maintain electrolyte balance and synergistically enhance the immune enhancement effect.

[0031] Preferably, in step S3, the optimal molar ratio of zinc and manganese for synergistic effect is 2:1. When the manganese content exceeds 80 mg / kg, it will inhibit the absorption of zinc, and zinc needs to be increased to 160 mg / kg simultaneously. In the production life extension project, the addition of vitamin C needs to adopt coating technology to prevent high-temperature degradation. There is a dosage window effect in the combination of betaine and silymarin.

[0032] Preferably, in step S4, when the amount of cottonseed meal exceeds 10%, in addition to iron supplementation, 0.05% ethoxyquin is added to enhance the detoxification effect of gossypol. It is recommended to establish a raw material database, update the raw material nutrient composition table every quarter, and use a linear programming model to optimize the formula to ensure that the nutritional cost is still optimized when the raw material price fluctuates.

[0033] Preferably, in step S5, when the vitamin E content exceeds 80 mg / kg, its synergistic antioxidant effect with selenium will weaken. At this time, the model parameters need to be refitted, and the Monte Carlo simulation should set a confidence interval (±15%) for raw material price fluctuations to ensure the economic feasibility of the optimized formula. It is recommended to update the model training data every quarter. When the coefficient of variation of the raw materials exceeds 10%, the sample size needs to be increased by 10% to improve the prediction accuracy.

[0034] (3) Beneficial effects

[0035] Compared with the prior art, the present invention provides a method for preparing a premix for enhanced laying hen production and processing, which has the following beneficial effects:

[0036] 1. This enhanced premix preparation method for laying hen production and processing significantly improves the production performance of laying hens through multi-dimensional precise control. In terms of nutritional component ratio, the form and content of vitamins and mineral elements are precisely set, from ensuring oviduct health to optimizing eggshell quality, fully meeting the needs of laying hens; functional additives target antioxidant, intestinal health and immune enhancement modules, effectively reducing oxidative stress, improving feed conversion rate and enhancing disease resistance; the integration of special functional modules further achieves high egg production rate, optimizes eggshell quality and extends production life. Combined with these measures, the peak egg-laying period of laying hens is extended by 2-3 weeks, the egg production rate at 72 weeks of age can still be maintained at more than 82%, the feed-to-egg ratio during the laying period is reduced to below 1.9:1, and the mortality rate throughout the entire process is controlled within 3%, thereby effectively improving the growth rate and egg production efficiency of the flock, ensuring eggshell quality, and reducing the risk of nutritional diseases such as rickets and reduced egg production, thereby greatly improving the economic benefits of laying hen farming.

[0037] 2. This enhanced premix preparation method for laying hen production and processing provides recommended amounts of core nutrients and makes dynamic adjustments based on regional differences and changes in raw materials. For example, vitamin C is added in high-altitude areas, and metabolic energy and amino acid concentrations are adjusted according to corn moisture, ensuring that the nutritional supply is always adapted to the actual laying hen farming situation. The dynamic nutrition management system uses the PDCA cycle and response surface analysis method to continuously optimize the formula, shortening the formula adjustment cycle to 7 days and reducing costs by 3-5%. Combined with the intelligent feeding system, the raw material composition and laying hen behavior are monitored in real time to achieve precise optimization of nutritional supply. Each step focuses on key points and precautions for key links, further ensuring the scientific and efficient preparation and application of the entire premix, providing reliable technical support for laying hen farming. BRIEF DESCRIPTION OF THE DRAWINGS

[0038] Figure 1 It is a flow chart of the preparation method of the present invention. DETAILED DESCRIPTION

[0039] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0040] Example 1:

[0041] A method for preparing a premix for enhanced laying hen production and processing, comprising the following steps:

[0042] S1. Construction of precise nutritional composition ratio

[0043] In establishing a basic nutritional framework, the construction of a vitamin system is a core project. Vitamin A is supplemented in the form of palmitate to ensure its stability during feed processing. A level of 8,000-12,000 IU per kilogram of feed should be maintained to ensure the integrity of the fallopian tube mucosa and the health of the visual system. The addition of 25-hydroxy D3, the metabolically active form of vitamin D3, needs to reach 2,000-3,000 IU / kg. It works synergistically with parathyroid hormone to significantly improve the efficiency of calcium and phosphorus deposition. Of particular note is the synergistic effect of B vitamins. Thiamine (B1) and riboflavin (B2) in a 1:2 ratio can increase carbohydrate metabolism efficiency by 15-20%, while the molecular docking of cobalamin (B12) and folic acid can increase the efficiency of methionine synthesis by more than 30%.

[0044] In terms of mineral balance, the use of amino acid chelated trace elements can increase bioavailability by 40%. Iron is added in the form of ferrous glycine, which prevents anemia and improves eggshell color. The molar ratio of magnesium ions to potassium ions is controlled at 1:3, which effectively maintains stable cellular osmotic pressure. In the calcium-phosphorus dynamic balance system, the available phosphorus level must reach 0.38-0.42%. By using a 7:3 ratio of calcium hydrogen phosphate to shell powder, the eggshell thickness can be increased to over 0.38mm, and the egg breakage rate can be reduced by 2-3 percentage points.

[0045] S2. Targeted Regulation of Functional Additives

[0046] The antioxidant defense system is constructed using a gradient antioxidant strategy: Vitamin E, a fat-soluble antioxidant, blocks lipid peroxidation chain reactions at a level of 50-80 mg / kg. Selenium is added in the form of yeast selenium to form glutathione peroxidase in the liver, which is 2.4 times more efficient at scavenging free radicals than inorganic selenium. Tea polyphenols, as natural antioxidants, can simultaneously scavenge water-soluble and fat-soluble free radicals, forming a synergistic antioxidant network.

[0047] Intestinal health management adopts a "three-dimensional regulation" model: Bacillus subtilis (1×10^8 CFU / g) inhibits the proliferation of harmful bacteria by secreting lipopeptides. A complex enzyme system of xylanase and β-glucanase degrades non-starch polysaccharides, releasing encapsulated nutrients. Mannan oligosaccharides adsorb intestinal pathogens and reduce their colonization ability. The synergistic effect of these three can increase feed conversion rate by 8-10% and reduce diarrhea rate by more than 50%.

[0048] The immune enhancement system uses a dual activation mechanism: yeast cell wall polysaccharides activate the phagocytic activity of macrophages, increasing serum IgG levels by 25%, while astragalus polysaccharides promote T lymphocyte proliferation and enhance cellular immune responses. Under heat stress conditions, this combined immune enhancer can maintain egg production at above 90%, an increase of 5-7 percentage points compared to the control group.

[0049] S3. System integration of special function modules

[0050] The high egg production rate control module is based on an ideal amino acid model. By optimizing the ratio of methionine to lysine (1.15:1) and maintaining a dynamic balance between threonine and tryptophan, it can extend the peak egg production period by 2-3 weeks. In terms of energy metabolism, the addition of medium-chain fatty acid glycerides can reduce liver ketone body production by 40%, ensuring stable ovarian function.

[0051] The eggshell quality optimization system uses nano-scale calcium carbonate particles (particle size <100nm), whose specific surface area is 5 times that of ordinary stone powder, which can increase calcium deposition efficiency by 35%. Combined with the synergistic effect of zinc and manganese elements, the eggshell strength can reach 3.8kg / cm 2 Above, the egg-shaped index is controlled in the ideal range of 1.30-1.35;

[0052] The production life extension project is achieved through a dual protective mechanism: the combination of vitamin C (200mg / kg) and betaine can reduce cortisol levels caused by heat stress by 28%. Silymarin, as a liver protectant, can increase liver glutathione peroxidase activity by 45%, effectively delaying liver cell aging. Practice has shown that this program can maintain the egg production rate of laying hens at 72 weeks of age at above 82%.

[0053] S4. Precision Nutrition Supply Program

[0054] In a 2% premix system, the recommended addition levels of core nutrients are: vitamin A 8000 IU / kg, vitamin D3 2500 IU / kg, vitamin E 60 mg / kg, selenium 0.3 mg / kg, methionine 0.15%, and threonine 0.08%. In actual application, dynamic adjustments need to be made based on the coefficient of variation of the raw materials. For example, when the moisture content of corn exceeds 14%, the metabolizable energy level needs to be deducted by 0.45 kcal / g, and the amino acid concentration should be adjusted accordingly.

[0055] Regional formulation adjustments follow the principle of "three factors": In high-altitude areas (>2000m), vitamin C needs to be increased to 300mg / kg to alleviate hypoxic stress. In hot and humid areas, adding 0.1% calcium propionate can inhibit mold growth. For diets using cottonseed meal, iron needs to be supplemented to 80mg / kg to antagonize gossypol toxicity.

[0056] S5. Dynamic Nutrition Management System

[0057] The effectiveness of the program was evaluated using a PDCA cycle: daily records of production indicators such as egg production rate, egg weight, and feed intake were recorded; weekly tests of egg quality parameters such as eggshell thickness and Haugh units were performed; and monthly serum biochemical indicators were analyzed. When egg production rate dropped by more than 2% for three consecutive days, a nutritional intervention program was initiated to rapidly restore production performance by adjusting the electrolyte balance (Na:K:Cl = 1:0.8:0.6) or supplementing with biotin (200 μg / kg).

[0058] Formula optimization uses response surface analysis to establish a multivariate regression model for egg production rate, eggshell strength, and feed conversion rate. Monte Carlo simulation technology can quickly determine the optimal formula combination for different production targets. Practice has shown that this system can shorten the premix formula adjustment cycle to 7 days and reduce formula costs by 3-5%.

[0059] In practical applications, it is recommended to use it in conjunction with an intelligent feeding system, monitor the raw material composition online through near-infrared spectroscopy, and combine the behavioral data of laying hens (such as feather pecking frequency and water drinking times) to achieve real-time dynamic optimization of nutritional supply. This intelligent nutritional management model can control the mortality rate of laying hens within 3% throughout the entire process and reduce the feed-to-egg ratio during the laying period to below 1.9:1.

[0060] Example 2:

[0061] A method for preparing a premix for enhanced laying hen production and processing, comprising the following steps:

[0062] S1. Construction of precise nutritional composition ratio

[0063] In establishing a basic nutritional framework, the construction of a vitamin system is a core project. Vitamin A is supplemented in the form of palmitate to ensure its stability during feed processing. A level of 8,000-12,000 IU per kilogram of feed should be maintained to ensure the integrity of the fallopian tube mucosa and the health of the visual system. The addition of 25-hydroxy D3, the metabolically active form of vitamin D3, needs to reach 2,000-3,000 IU / kg. It works synergistically with parathyroid hormone to significantly improve the efficiency of calcium and phosphorus deposition. Of particular note is the synergistic effect of B vitamins. Thiamine (B1) and riboflavin (B2) in a 1:2 ratio can increase carbohydrate metabolism efficiency by 15-20%, while the molecular docking of cobalamin (B12) and folic acid can increase the efficiency of methionine synthesis by more than 30%.

[0064] In terms of mineral balance, the use of amino acid chelated trace elements can increase bioavailability by 40%. Iron is added in the form of ferrous glycine, which prevents anemia and improves eggshell color. The molar ratio of magnesium ions to potassium ions is controlled at 1:3, which effectively maintains stable cellular osmotic pressure. In the calcium-phosphorus dynamic balance system, the available phosphorus level must reach 0.38-0.42%. By using a 7:3 ratio of calcium hydrogen phosphate to shell powder, the eggshell thickness can be increased to over 0.38mm, and the egg breakage rate can be reduced by 2-3 percentage points.

[0065] S2. Targeted Regulation of Functional Additives

[0066] The antioxidant defense system is constructed using a gradient antioxidant strategy: Vitamin E, a fat-soluble antioxidant, blocks lipid peroxidation chain reactions at a level of 50-80 mg / kg. Selenium is added in the form of yeast selenium to form glutathione peroxidase in the liver, which is 2.4 times more efficient at scavenging free radicals than inorganic selenium. Tea polyphenols, as natural antioxidants, can simultaneously scavenge water-soluble and fat-soluble free radicals, forming a synergistic antioxidant network.

[0067] Intestinal health management adopts a "three-dimensional regulation" model: Bacillus subtilis (1×10^8 CFU / g) inhibits the proliferation of harmful bacteria by secreting lipopeptides. A complex enzyme system of xylanase and β-glucanase degrades non-starch polysaccharides, releasing encapsulated nutrients. Mannan oligosaccharides adsorb intestinal pathogens and reduce their colonization ability. The synergistic effect of these three can increase feed conversion rate by 8-10% and reduce diarrhea rate by more than 50%.

[0068] The immune enhancement system uses a dual activation mechanism: yeast cell wall polysaccharides activate the phagocytic activity of macrophages, increasing serum IgG levels by 25%, while astragalus polysaccharides promote T lymphocyte proliferation and enhance cellular immune responses. Under heat stress conditions, this combined immune enhancer can maintain egg production at above 90%, an increase of 5-7 percentage points compared to the control group.

[0069] S3. System integration of special function modules

[0070] The high egg production rate control module is based on an ideal amino acid model. By optimizing the ratio of methionine to lysine (1.15:1) and maintaining a dynamic balance between threonine and tryptophan, it can extend the peak egg production period by 2-3 weeks. In terms of energy metabolism, the addition of medium-chain fatty acid glycerides can reduce liver ketone body production by 40%, ensuring stable ovarian function.

[0071] The eggshell quality optimization system uses nano-scale calcium carbonate particles (particle size <100nm), whose specific surface area is 5 times that of ordinary stone powder, which can increase calcium deposition efficiency by 35%. Combined with the synergistic effect of zinc and manganese elements, the eggshell strength can reach 3.8kg / cm 2Above, the egg-shaped index is controlled in the ideal range of 1.30-1.35;

[0072] The production life extension project is achieved through a dual protective mechanism: the combination of vitamin C (200mg / kg) and betaine can reduce cortisol levels caused by heat stress by 28%. Silymarin, as a liver protectant, can increase liver glutathione peroxidase activity by 45%, effectively delaying liver cell aging. Practice has shown that this program can maintain the egg production rate of laying hens at 72 weeks of age at above 82%.

[0073] S4. Precision Nutrition Supply Program

[0074] In a 2% premix system, the recommended addition levels of core nutrients are: vitamin A 8000 IU / kg, vitamin D3 2500 IU / kg, vitamin E 60 mg / kg, selenium 0.3 mg / kg, methionine 0.15%, and threonine 0.08%. In actual application, dynamic adjustments need to be made based on the coefficient of variation of the raw materials. For example, when the moisture content of corn exceeds 14%, the metabolizable energy level needs to be deducted by 0.45 kcal / g, and the amino acid concentration should be adjusted accordingly.

[0075] Regional formulation adjustments follow the principle of "three factors": In high-altitude areas (>2000m), vitamin C needs to be increased to 300mg / kg to alleviate hypoxic stress. In hot and humid areas, adding 0.1% calcium propionate can inhibit mold growth. For diets using cottonseed meal, iron needs to be supplemented to 80mg / kg to antagonize gossypol toxicity.

[0076] S5. Dynamic nutrition management system

[0077] The effectiveness of the program was evaluated using a PDCA cycle: daily records of production indicators such as egg production rate, egg weight, and feed intake were recorded; weekly tests of egg quality parameters such as eggshell thickness and Haugh units were performed; and monthly serum biochemical indicators were analyzed. When egg production rate dropped by more than 2% for three consecutive days, a nutritional intervention program was initiated to rapidly restore production performance by adjusting the electrolyte balance (Na:K:Cl = 1:0.8:0.6) or supplementing with biotin (200 μg / kg).

[0078] Formula optimization uses response surface analysis to establish a multivariate regression model for egg production rate, eggshell strength, and feed conversion rate. Monte Carlo simulation technology can quickly determine the optimal formula combination for different production targets. Practice has shown that this system can shorten the premix formula adjustment cycle to 7 days and reduce formula costs by 3-5%.

[0079] In practical applications, it is recommended to use it in conjunction with an intelligent feeding system, monitor the raw material composition online through near-infrared spectroscopy, and combine the behavioral data of laying hens (such as feather pecking frequency and water drinking times) to achieve real-time dynamic optimization of nutritional supply. This intelligent nutritional management model can control the mortality rate of laying hens within 3% throughout the entire process and reduce the feed-to-egg ratio during the laying period to below 1.9:1.

[0080] Specifically, in step S1, 25-hydroxy D3 is highly photosensitivity, and the premix should be stored away from light. The actual amount added needs to be dynamically adjusted according to the storage time (increase the amount by 5% every 30 days of storage). The compatibility of B vitamins needs to pay attention to the influence of pH value. When the pH of the premix is lower than 5.5, the stability of thiamine will decrease by 20%. It is recommended to add 1% sodium bicarbonate for buffering and regulation.

[0081] Specifically, in step S1, the particle size distribution of the calcium source has a significant impact on eggshell quality. Shell powder should be controlled to contain particles of 40-60 mesh at a ratio of more than 70% to ensure sustained calcium release. When phytase is used, the available phosphorus level can be reduced by 0.05%, but sodium must be supplemented simultaneously to maintain electrolyte balance.

[0082] Specifically, in step S2, when constructing the antioxidant defense system, special attention should be paid to the synergistic enhancement threshold of each component. When the added amount of tea polyphenols exceeds 200 mg / kg, it may compete with vitamin E for absorption. It is recommended to achieve sustained release through lipid encapsulation technology. At the same time, the bioavailability of yeast selenium is significantly affected by storage conditions. After 6 months of storage in a high temperature and high humidity environment, the activity loss can reach 35%. Its effective content needs to be tested regularly.

[0083] Specifically, in step S2, the tempering temperature must be controlled not to exceed 85°C during the granulation process to ensure the survival rate of live bacteria. The dual activation mechanism of the immune enhancement system is dose-sensitive: when the addition of yeast cell wall polysaccharide exceeds 1500 mg / kg, it may cause immunosuppression, and the optimal compatibility concentration of astragalus polysaccharide is 500-800 mg / kg. Under heat stress conditions, it is recommended to simultaneously supplement 0.3% potassium chloride and 0.2% sodium bicarbonate to maintain electrolyte balance and synergistically enhance the immune enhancement effect.

[0084] Specifically, in step S3, the optimal molar ratio of zinc and manganese for synergistic effect is 2:1. When the manganese content exceeds 80 mg / kg, it will inhibit the absorption of zinc, and zinc needs to be increased to 160 mg / kg simultaneously. In the production life extension project, the addition of vitamin C requires the use of coating technology to prevent high-temperature degradation. There is a dosage window effect when combining betaine and silymarin.

[0085] Specifically, in step S4, when the cottonseed meal dosage exceeds 10%, in addition to iron supplementation, 0.05% ethoxyquin needs to be added to enhance the detoxification effect of gossypol. It is recommended to establish a raw material database, update the raw material nutritional composition table every quarter, and use a linear programming model to optimize the formula to ensure that the nutritional cost can be maintained at the optimal level when the raw material price fluctuates.

[0086] Specifically, in step S5, when the vitamin E content exceeds 80 mg / kg, its synergistic antioxidant effect with selenium will weaken. At this time, the model parameters need to be refitted. The Monte Carlo simulation should set a confidence interval (±15%) for raw material price fluctuations to ensure the economic feasibility of the optimized formula. It is recommended to update the model training data every quarter. When the raw material coefficient of variation exceeds 10%, the sample size needs to be increased by 10% to improve the prediction accuracy.

[0087] In developing precise nutritional ingredient ratios, vitamins and minerals are meticulously formulated, such as specific forms and amounts of vitamins and specific proportions of trace elements. Targeted regulation of functional additives addresses antioxidant, intestinal health, and immune enhancement. Specialized functional modules integrate solutions for increasing egg production, optimizing eggshell quality, and extending production life. Precise nutritional supply plans provide recommended amounts of core nutrients and principles for regionalized formula adjustments. A dynamic nutritional management system evaluates results through the PDCA cycle, optimizes formulas using the response surface methodology, and recommends integrating intelligent feeding systems for dynamic optimization. Each step also addresses key aspects and precautions, such as feed storage, ingredient synergy, dosage control, and model optimization.

[0088] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to these embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the appended claims and their equivalents.

Claims

1. A method for preparing a premix for enhanced laying hen production and processing, comprising the following steps: S1. Construction of precise nutritional composition ratio In establishing a basic nutritional framework, the construction of a vitamin system is a core project. Vitamin A is supplemented in the form of palmitate to ensure its stability during feed processing. A level of 8,000-12,000 IU per kilogram of feed should be maintained to ensure the integrity of the fallopian tube mucosa and the health of the visual system. The addition of 25-hydroxy D3, the metabolically active form of vitamin D3, needs to reach 2,000-3,000 IU / kg. It works synergistically with parathyroid hormone to significantly improve the efficiency of calcium and phosphorus deposition. Of particular note is the synergistic effect of B vitamins. Thiamine (B1) and riboflavin (B2) in a 1:2 ratio can increase carbohydrate metabolism efficiency by 15-20%, while the molecular docking of cobalamin (B12) and folic acid can increase the efficiency of methionine synthesis by more than 30%. In terms of mineral balance, the use of amino acid chelated trace elements can increase bioavailability by 40%. Iron is added in the form of ferrous glycine, which prevents anemia and improves eggshell color. The molar ratio of magnesium ions to potassium ions is controlled at 1:3, which effectively maintains stable cellular osmotic pressure. In the calcium-phosphorus dynamic balance system, the available phosphorus level must reach 0.38-0.42%. By using a 7:3 ratio of calcium hydrogen phosphate to shell powder, the eggshell thickness can be increased to over 0.38mm, and the egg breakage rate can be reduced by 2-3 percentage points. S2. Targeted Regulation of Functional Additives The antioxidant defense system is constructed using a gradient antioxidant strategy: Vitamin E, a fat-soluble antioxidant, blocks lipid peroxidation chain reactions at a level of 50-80 mg / kg. Selenium is added in the form of yeast selenium to form glutathione peroxidase in the liver, which is 2.4 times more efficient at scavenging free radicals than inorganic selenium. Tea polyphenols, as natural antioxidants, can simultaneously scavenge water-soluble and fat-soluble free radicals, forming a synergistic antioxidant network. Intestinal health management adopts a "three-dimensional regulation" model: Bacillus subtilis (1×10^8 CFU / g) inhibits the proliferation of harmful bacteria by secreting lipopeptides. A complex enzyme system of xylanase and β-glucanase degrades non-starch polysaccharides, releasing encapsulated nutrients. Mannan oligosaccharides adsorb intestinal pathogens and reduce their colonization ability. The synergistic effect of these three can increase feed conversion rate by 8-10% and reduce diarrhea rate by more than 50%. The immune enhancement system uses a dual activation mechanism: yeast cell wall polysaccharides activate the phagocytic activity of macrophages, increasing serum IgG levels by 25%, while astragalus polysaccharides promote T lymphocyte proliferation and enhance cellular immune responses. Under heat stress conditions, this combined immune enhancer can maintain egg production at above 90%, an increase of 5-7 percentage points compared to the control group. S3. System integration of special function modules The high egg production rate control module is based on an ideal amino acid model. By optimizing the ratio of methionine to lysine (1.15:1) and maintaining a dynamic balance between threonine and tryptophan, it can extend the peak egg production period by 2-3 weeks. In terms of energy metabolism, the addition of medium-chain fatty acid glycerides can reduce liver ketone body production by 40%, ensuring stable ovarian function. The eggshell quality optimization system uses nano-scale calcium carbonate particles (particle size <100nm), whose specific surface area is 5 times that of ordinary stone powder, which can increase calcium deposition efficiency by 35%. Combined with the synergistic effect of zinc and manganese elements, the eggshell strength can reach 3.8kg / cm 2 Above, the egg-shaped index is controlled in the ideal range of 1.30-1.35; The production life extension project is achieved through a dual protective mechanism: the combination of vitamin C (200mg / kg) and betaine can reduce cortisol levels caused by heat stress by 28%. Silymarin, as a liver protectant, can increase liver glutathione peroxidase activity by 45%, effectively delaying liver cell aging. Practice has shown that this program can maintain the egg production rate of laying hens at 72 weeks of age at above 82%. S4. Precision Nutrition Supply Program In a 2% premix system, the recommended addition levels of core nutrients are: vitamin A 8000 IU / kg, vitamin D3 2500 IU / kg, vitamin E 60 mg / kg, selenium 0.3 mg / kg, methionine 0.15%, and threonine 0.08%. In actual application, dynamic adjustments need to be made based on the coefficient of variation of the raw materials. For example, when the moisture content of corn exceeds 14%, the metabolizable energy level needs to be deducted by 0.45 kcal / g, and the amino acid concentration should be adjusted accordingly. Regional formulation adjustments follow the principle of "three factors": In high-altitude areas (>2000m), vitamin C needs to be increased to 300mg / kg to alleviate hypoxic stress. In hot and humid areas, adding 0.1% calcium propionate can inhibit mold growth. For diets using cottonseed meal, iron needs to be supplemented to 80mg / kg to antagonize gossypol toxicity. S5. Dynamic Nutrition Management System The effectiveness of the program was evaluated using a PDCA cycle: daily records of production indicators such as egg production rate, egg weight, and feed intake were recorded; weekly tests of egg quality parameters such as eggshell thickness and Haugh units were performed; and monthly serum biochemical indicators were analyzed. When egg production rate dropped by more than 2% for three consecutive days, a nutritional intervention program was initiated to rapidly restore production performance by adjusting the electrolyte balance (Na:K:Cl = 1:0.8:0.6) or supplementing with biotin (200 μg / kg). Formula optimization uses response surface analysis to establish a multivariate regression model for egg production rate, eggshell strength, and feed conversion rate. Monte Carlo simulation technology can quickly determine the optimal formula combination for different production targets. Practice has shown that this system can shorten the premix formula adjustment cycle to 7 days and reduce formula costs by 3-5%. In practical applications, it is recommended to use it in conjunction with an intelligent feeding system, monitor the raw material composition online through near-infrared spectroscopy, and combine the behavioral data of laying hens (such as feather pecking frequency and water drinking times) to achieve real-time dynamic optimization of nutritional supply. This intelligent nutritional management model can control the mortality rate of laying hens within 3% throughout the entire process and reduce the feed-to-egg ratio during the laying period to below 1.9:

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2. The method for preparing a premix for enhanced laying hen production and treatment according to claim 1, characterized in that: In step S1, 25-hydroxy D3 is highly photosensitivity, and the premix should be stored away from light. The actual amount added needs to be dynamically adjusted according to the storage time (increase the amount by 5% every 30 days of storage). The compatibility of B vitamins needs to pay attention to the influence of pH value. When the pH of the premix is lower than 5.5, the stability of thiamine will decrease by 20%. It is recommended to add 1% sodium bicarbonate for buffering and regulation.

3. The method for preparing a premix for enhanced laying hen production and treatment according to claim 1, characterized in that: In step S1, the particle size distribution of the calcium source has a significant impact on the quality of the eggshell. The shell powder should be controlled to have 40-60 mesh particles accounting for more than 70% to ensure the continuous release of calcium. When phytase is used, the effective phosphorus level can be reduced by 0.05%, but sodium needs to be supplemented simultaneously to maintain electrolyte balance.

4. The method for preparing a premix for enhanced laying hen production and treatment according to claim 1, wherein: In step S2, when constructing the antioxidant defense system, special attention should be paid to the synergistic enhancement threshold of each component. When the added amount of tea polyphenols exceeds 200 mg / kg, it may compete with vitamin E for absorption. It is recommended to achieve sustained release through lipid encapsulation technology. At the same time, the bioavailability of yeast selenium is significantly affected by storage conditions. After storage in a high temperature and high humidity environment for 6 months, the activity loss can reach 35%, and its effective content needs to be regularly tested.

5. The method for preparing a premix for enhanced laying hen production and treatment according to claim 1, wherein: In step S2, the tempering temperature must be controlled not to exceed 85°C during the granulation process to ensure the survival rate of live bacteria. The dual activation mechanism of the immune enhancement system is dose-sensitive: when the amount of yeast cell wall polysaccharide added exceeds 1500 mg / kg, it may cause immunosuppression, and the optimal compatibility concentration of astragalus polysaccharide is 500-800 mg / kg. Under heat stress conditions, it is recommended to simultaneously supplement 0.3% potassium chloride and 0.2% sodium bicarbonate to maintain electrolyte balance and synergistically enhance the immune enhancement effect.

6. The method for preparing a premix for enhanced laying hen production and treatment according to claim 1, characterized in that: In step S3, the optimal molar ratio of zinc and manganese for synergistic effect is 2:

1. When the manganese content exceeds 80 mg / kg, it will inhibit the absorption of zinc, and zinc needs to be increased to 160 mg / kg simultaneously. In the production life extension project, the addition of vitamin C needs to adopt coating technology to prevent high-temperature degradation. There is a dosage window effect when combining betaine and silymarin.

7. The method for preparing a premix for enhanced laying hen production and treatment according to claim 1, characterized in that: In step S4, when the amount of cottonseed meal exceeds 10%, in addition to iron supplementation, 0.05% ethoxyquin needs to be added to enhance the detoxification effect of gossypol. It is recommended to establish a raw material database, update the raw material nutritional composition table every quarter, and use a linear programming model to optimize the formula to ensure that the nutritional cost can be maintained at the optimal level when the raw material price fluctuates.

8. The method for preparing a premix for enhanced laying hen production and treatment according to claim 1, characterized in that: In step S5, when the vitamin E content exceeds 80 mg / kg, its synergistic antioxidant effect with selenium will weaken. At this time, the model parameters need to be refitted. The Monte Carlo simulation should set a confidence interval (±15%) for raw material price fluctuations to ensure the economic feasibility of the optimized formula. It is recommended to update the model training data every quarter. When the raw material coefficient of variation exceeds 10%, the sample size needs to be increased by 10% to improve the prediction accuracy.

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