Special medical and special composite diet formula for obesity and overweight and production process

Abstract

The invention discloses a special medical and special dietary composite diet formula for obesity and overweight and a production technology, and belongs to the technical field of functional food, and the special medical and special dietary composite diet formula for obesity and overweight is prepared through uniform component design (a medicine and food homology group, a precise nutrition group, a low-GI control group and a taste optimization group) in combination with a three-stage process system (special medical / special dietary / nutrition composite diet). And all-around intervention from lipid metabolism regulation and control, intestinal flora regulation to weight management is realized. The product conforms to the national standard of FSMP, fills the blank of special nutritional preparations for obesity and overweight, serves as a core measure of an out-of-hospital management scheme of weight monitoring, scientific exercise and nutritional diet intervention of obesity and overweight patients, and is combined with in-hospital treatment dominated by traditional Chinese medicine to form an in-hospital and out-of-hospital weight loss management medical model.

Description

Technical Field

[0001] The present invention belongs to the technical field of functional foods, and specifically relates to a special medical and special dietary compound diet formula and production process for obesity and overweight, which is suitable for improving lipid metabolism disorders, regulating intestinal flora, controlling weight and out-of-hospital nutritional intervention. Background Art

[0002] Obesity (BMI ≥ 28) and overweight (BMI 24 ≤ < 27.9) are major global public health issues. Their core characteristics are the abnormal accumulation of body fat, accompanied by lipid metabolism disorders and imbalanced intestinal flora, which significantly increase the risk of complications such as cardiovascular and cerebrovascular diseases and type 2 diabetes. According to the World Health Organization, the number of overweight people worldwide exceeds 1.9 billion, and the number of obese people exceeds 650 million, with the trend toward younger people. Most of the existing products on the market rely on a single ingredient (such as dietary fiber or low-calorie formulas), and have not systematically integrated the traditional Chinese medicine theory of "clearing phlegm and dampness, clearing the bowels and eliminating turbidity" with modern metabolic regulation mechanisms (such as AMPK pathway activation and intestinal flora regulation). The bioavailability of active ingredients of traditional Chinese medicine (such as radish seed sinapines and lotus leaf alkaloids) is low, and there is a lack of support for modern preparation technologies such as supercritical extraction and nano-encapsulation. Differentiated formulas have not been designed for the degree of obesity (mild 24≤BMI<27.9, moderate 28≤BMI<32.5, severe BMI≥32.5), and the dosage of nutritional components (such as chromium-rich yeast and probiotics) has not been optimized. The amount is not precisely matched with the degree of metabolic disorder, resulting in variable intervention effects; the four-dimensional synergy of "active ingredients of traditional Chinese medicine - targeted nutrients - low GI diet - taste optimization" is not achieved: the regulatory effect of active ingredients of traditional Chinese medicine on lipid metabolism does not form a synergistic effect with targeted nutrients such as L-carnitine protein and astaxanthin; the sustained-release mechanism of low GI carbohydrates (such as oat β-glucan and konjac glucomannan) is not deeply integrated with intestinal flora regulation (such as Lactobacillus plantarum LP-Onlly); taste optimization relies on artificial additives, and the application of natural flavor substances (such as sea buckthorn seed powder and lotus seed powder) is insufficient, resulting in low user compliance.

[0003] The existing production processes of foods for special medical purposes (FSMP), special dietary foods, and nutritional compound meals are not differentiated, and key parameters (such as the number of probiotic encapsulation layers and the extraction pressure of traditional Chinese medicine ingredients) are not adapted to the product functional positioning, affecting the stability of active ingredients (such as L-carnitine retention rate and probiotic survival rate). Summary of the Invention

[0004] The purpose of the present invention is to provide a special medical and special dietary compound diet formula and production process for obesity and overweight based on the traditional Chinese medicine theory of "clearing phlegm and removing dampness" and the synergy of modern metabolic regulation mechanisms. Through the scientific ratio of medicinal and edible ingredients, precise nutrients, low GI diet and taste-optimized ingredients, multi-target intervention on obesity and overweight is achieved, and a graded dosage system is established to adjust the proportion of each ingredient in the formula and the process parameters according to the degree of obesity (mild, moderate, severe) to achieve precise nutritional intervention.

[0005] To solve the above technical problems, the present invention provides a special medical and special dietary compound diet formula for obesity and overweight, which is suitable for preparing special medical formula foods, special dietary foods or nutritional compound diet foods, comprising:

[0006] The medicinal and edible group is composed of medicinal and edible ingredients that have the functions of clearing phlegm and turbidity, promoting dampness and reducing swelling, promoting bowel movements and relieving constipation, and regulating qi and relieving stagnation. By regulating phlegm and dampness metabolism in the body, improving intestinal motility and fat decomposition, it intervenes in obesity-related metabolic disorders from the perspective of traditional Chinese medicine theory;

[0007] The precision nutrition group includes ingredients with metabolic and intestinal microecological regulatory functions and functional additives, which precisely intervene in obesity-related pathological mechanisms through modern nutritional science;

[0008] The low GI control group, composed of water-soluble dietary fiber and slow-release carbohydrates, controls energy intake and glucose and lipid metabolism by delaying gastric emptying, inhibiting blood sugar spikes, and enhancing satiety.

[0009] The taste optimization group, composed of natural sweeteners and taste modifiers, simulates the color, aroma, and taste of natural ingredients to improve product palatability without artificial additives, thereby enhancing user compliance for long-term consumption.

[0010] The prescription is designed according to the degree of obesity:

[0011] For severe obesity, the proportion of medicinal and edible components is 30wt%, the proportion of precise nutrition components is 35wt%, the proportion of low GI value control components is 20wt%, and the proportion of taste optimization components is 15wt%;

[0012] For moderate obesity, the proportion of medicinal and edible components is 25wt%, the proportion of precise nutrition components is 35wt%, the proportion of low GI value control components is 25wt%, and the proportion of taste optimization components is 15wt%;

[0013] For mild obesity, the proportion of medicinal and edible components is 20wt%, the proportion of precise nutrition components is 35wt%, the proportion of low GI value control components is 30wt%, and the proportion of taste optimization components is 15wt%.

[0014] Furthermore, the medicine-food group includes radish seeds, white mustard seeds, perilla seeds, wax gourd seeds, soapberry seeds, safflower seeds, corn silk, wax gourd peel, cassia seeds, lotus leaves and tangerine peel. Among them, radish seeds, white mustard seeds, perilla seeds, wax gourd seeds and safflower seeds can clear phlegm and dampness in the body, improve lipid metabolism disorders, and inhibit fat accumulation: radish seeds (downward qi and resolve phlegm), white mustard seeds (warming the lungs and resolving phlegm) and wax gourd seeds (clearing the lungs and resolving phlegm) are rich in sinapines and flavonoids, which have lipid-lowering and anti-inflammatory effects; perilla seeds (downward qi and resolve phlegm) and safflower seeds (removing accumulation and softening hard masses) contain volatile oils and fatty acids, which promote fat decomposition and excretion; corn silk, wax gourd peel, cassia seed and lotus leaf can promote water metabolism, improve water retention in the body, reduce edema and swelling of fat cells: corn silk (diuretic and stranguria relief) and wax gourd peel (diuretic and detumescent) are rich in saponins and polysaccharides, which can promote sodium ion excretion and regulate renal water metabolism; cassia seed (clearing heat and promoting diuresis) and lotus leaf (diuretic and yang-raising) contain anthraquinones and nuciferine, which inhibit fat synthesis and promote fat Fatty acid oxidation; soap seeds, cassia seeds, radish seeds, and tangerine peel can also enhance intestinal peristalsis, soften stool, improve constipation and intestinal toxin accumulation, and reduce calorie absorption: soap seeds (moisturizing and laxative) and cassia seeds (lubricating and laxative) contain dietary fiber and phytosterols, which increase stool volume and regulate intestinal flora; radish seeds (reducing gas and relieving constipation) and tangerine peel (regulating qi and removing stagnation) stimulate intestinal smooth muscle contraction through volatile oil components and improve intestinal qi stagnation; tangerine peel, perilla seeds, white mustard seeds, and water safflower seeds can also dredge the qi mechanism, improve qi stagnation and blood stasis, and promote blood circulation and metabolism of adipose tissue: tangerine peel (regulating qi and strengthening the spleen) and perilla seeds (regulating qi and reducing adverse reactions) contain hesperidin and rosmarinic acid, which have the effects of regulating lipid metabolism and anti-inflammatory; white mustard seeds (promoting qi and dispersing stagnation) and water safflower seeds (breaking blood and promoting qi) promote lipolysis by regulating the AMPK pathway. The ingredients that clear phlegm and turbidity and promote dampness and swelling work together to eliminate pathological products (phlegm and dampness) in the body, while the ingredients that regulate qi and relieve stagnation improve the circulation of qi and blood, and prevent the re-accumulation of phlegm and dampness; the ingredients that promote bowel movements directly improve the excretion function of the intestine, and work together with the probiotics in the precision nutrition group to regulate the intestinal flora, forming a virtuous cycle of "intestinal patency-improved lipid metabolism"; all ingredients are selected from the national approved catalog of medicine and food, and are both safe and functional, and can be used for long-term nutritional intervention.

[0015] Furthermore, the components with metabolic regulation function include trace elements (such as Cr 3+), carotenoids (such as astaxanthin) and carnitine compounds (such as L-carnitine protein), which are used to activate the AMPK pathway, promote fatty acid oxidation and improve insulin resistance; the ingredients with intestinal microecological regulation function include probiotics (such as Lactobacillus plantarum LP-Onlly, Bifidobacterium BB-12) and prebiotics (such as arabinoxylan, polydextrose), which are used to regulate the balance of intestinal flora and enhance intestinal barrier function; the functional additives include natural sweeteners (erythritol), emulsifiers (phospholipids) and stabilizers (sodium carboxymethyl cellulose), which are used to improve ingredient stability and formula compatibility.

[0016] Furthermore, the water-soluble dietary fiber includes β-glucan and glucomannan, which have high viscosity and can form an intestinal gel layer to delay the digestion of carbohydrates; the slow-release carbohydrates include chia seed ultrafine powder, which is rich in ω-3 fatty acids and dietary fiber, and has both low GI value and nutritional density. The water-soluble dietary fiber and slow-release carbohydrates are optimized through ultrafine grinding, nanofiber processing and other technologies to optimize the digestion and absorption rate of carbohydrates, forming a dietary structure with a low glycemic index (GI≤55).

[0017] Furthermore, the natural sweeteners include sea buckthorn seed powder (rich in vitamin C and natural fruit acid) and lotus seed powder (elegant and fragrant), providing low-calorie sweetness and flavor and taste regulators; the taste regulator includes gorgon fruit powder (increasing the fineness of the powder), improving the product's solubility and swallowing taste, and reducing the astringency or roughness of traditional weight management products; by compounding the natural aroma and sweetness of ingredients with the same origin as medicine and food (such as tangerine peel and lotus leaf), a rich sensory experience is formed.

[0018] The special medical and dietary compound formula for obesity and overweight of the present invention combines the traditional Chinese medicine theory of "clearing phlegm and removing dampness" with the modern metabolic regulation mechanism, uses medicinal and edible ingredients to regulate the phlegm and dampness state in the body, improves metabolism, makes up for the shortcomings of existing products in theoretical application, and provides a more comprehensive mechanism of action for weight management; designs a unified component grading system for different degrees of obesity (severe, moderate, mild), accurately adjusts the ratio of medicinal and edible functional groups and low GI control groups, meets the special nutritional needs of different obese people, and improves the intervention effect; realizes the four-dimensional synergistic intervention of "traditional Chinese medicine activity-targeted nutrition-low GI diet-taste optimization": medicinal and edible ingredients regulate metabolism, targeted nutrition targets intestinal flora and insulin resistance, low GI diet controls blood sugar fluctuations, taste optimization improves user compliance, and multiple dimensions work together to comprehensively regulate the body's metabolic function; the formula ingredients comply with relevant laws and regulations, the medicinal and edible ingredients are from the "Catalogue of Medicinal and Food Homologous Sources (2023)", and the amount of L-carnitine protein added complies with the provisions of GB 24154-2015. After stability testing, the product has a high active ingredient retention rate and probiotic survival rate during its shelf life, and its quality is stable, ensuring safe use by consumers.

[0019] The present invention also provides a production process for special medical and special dietary compound meals for obesity and overweight. For special medical, special dietary and nutritional compound meal products, different precision ingredient processing technologies (nanoscale / ultramicroscale / ordinary level) and active ingredient retention processes are respectively adopted.

[0020] For special medical foods, the production process includes the following steps:

[0021] Treatment of the medicine-food group: Supercritical CO2 extraction (pressure 25-35 MPa, temperature 40-45°C, extraction time 1.5-2 h) was used to extract the active ingredients of radish seeds, perilla seeds, white mustard seeds, wax gourd seeds, sapodilla seeds, safflower seeds, corn silk, wax gourd peel, cassia seeds, lotus leaves, and tangerine peel. The active ingredients of perilla seeds and cassia seeds were nano-encapsulated to improve the extraction rate and stability of the active ingredients of traditional Chinese medicine.

[0022] Precision Nutrition Group Treatment: Carnitine compounds are encapsulated using microencapsulation technology (sodium alginate-chitosan encapsulation) to create carnitine compound microcapsules with a particle size of ≤200nm. Triple encapsulation of probiotics (calcium alginate-chitosan-pectin layer encapsulation, gastric acid resistance survival rate ≥95%) produces probiotics with a particle size of ≤500nm to ensure the stability of the active ingredients during storage and digestion. Other precision nutrition group components are nano-crushed to a particle size of ≤500nm.

[0023] Low GI control group treatment: water-soluble dietary fiber was extruded (expansion degree ≥ 3 times, fiber diameter ≤ 50nm) or high-pressure homogenized, and slow-release carbohydrates were ultrafinely ground into ultrafine powder to delay carbohydrate release;

[0024] Taste optimization group treatment: Sea buckthorn seeds were supercritical CO2 extracted and ultrafinely ground to a particle size of ≦50μm to obtain sea buckthorn seed powder; lotus seeds were low-temperature roasted and nano-ground to obtain lotus seed powder; gorgon fruit were microwave-dried and ground to obtain gorgon fruit powder;

[0025] Mixing and packaging: The medicine and food group, precision nutrition group, low GI control group and taste optimization group are mixed evenly in proportion according to the degree of obesity, and sealed in aluminum foil bags using nitrogen-filled packaging technology to ensure product sterility and stability.

[0026] For special dietary foods, the production process includes the following steps:

[0027] Treatment of the medicine-food group: Radish seeds, white mustard seeds, perilla seeds, wax gourd seeds, sapodilla seeds, safflower seeds, corn silk, wax gourd peel, cassia seeds, lotus leaves, and tangerine peel were freeze-dried separately and then cryopreserved to a particle size of ≤15 μm to retain their active ingredients;

[0028] Precision Nutrition Group Treatment: Carnitine compounds were spray-dried at low temperature; probiotics were double-encapsulated (calcium alginate-chitosan encapsulation, survival rate ≥ 90%), and other precision nutrition components were ultrafinely ground to a particle size of ≤ 50 μm to improve solubility and absorption;

[0029] Low GI control group treatment: water-soluble dietary fiber and slow-release carbohydrates were low-temperature dried to a moisture content of ≤5%, and then ultra-finely ground to maintain low GI properties;

[0030] Taste optimization group treatment: Sea buckthorn seeds were supercritical CO2 extracted and ultrafinely ground to a particle size of ≦50μm to obtain sea buckthorn seed powder; lotus seeds were low-temperature roasted and nano-ground to obtain lotus seed powder; gorgon fruit were microwave-dried and ground to obtain gorgon fruit powder, and then mixed evenly;

[0031] Mixing and packaging: The medicine and food group, precise nutrition group, low GI control group and taste optimization group are mixed evenly in proportion according to the degree of obesity, and vacuum packaging technology is used to ensure product quality.

[0032] For the nutritional compound dietary product, the production process includes the following steps:

[0033] Treatment of the medicinal and edible group: radish seeds, white mustard seeds, perilla seeds, wax gourd seeds, sapodilla seeds, safflower seeds, corn silk, wax gourd peel, cassia seeds, lotus leaves, and tangerine peel were crushed separately and passed through an 80-mesh sieve, and then dried with hot air to simplify the process and reduce costs;

[0034] Precision Nutrition Group Processing: Probiotics are embedded in probiotics, and other precision nutrition group components are crushed and sieved normally, and mixed conventionally (water activity ≤ 0.65) to ensure uniform distribution of ingredients;

[0035] Low GI control group treatment: water-soluble dietary fiber and slow-release carbohydrates were hot-air dried to a moisture content of ≤8% and then crushed in ordinary mode;

[0036] Taste optimization group treatment: Sea buckthorn seeds were supercritical CO2 extracted and ultrafinely ground to a particle size of ≦50μm to obtain sea buckthorn seed powder; lotus seeds were low-temperature roasted and nano-ground to obtain lotus seed powder; gorgon fruit were microwave-dried and ground to obtain gorgon fruit powder, and then mixed evenly;

[0037] Mixing and packaging: The medicine and food group, precise nutrition group, low GI control group and taste optimization group are mixed evenly in proportion according to the degree of obesity, and ordinary packaging technology is used to meet the needs of daily nutritional intervention.

[0038] The present invention adopts a three-level formula system (30%, 25%, and 20% proportion of medicine and food groups) to dynamically adapt to the degree of obesity; differentiated process standards (special medical: supercritical extraction / microencapsulation; special diet: freeze-drying / wall breaking; nutritional compound diet: ordinary crushing) to distinguish the technical standards of special medical foods, special dietary foods, and nutritional compound diets.

[0039] This invention develops differentiated production processes tailored to the diverse characteristics of special medical formula foods, special dietary foods, and nutritional complex foods. For example, special medical formula foods utilize supercritical CO2 extraction and nanoencapsulation technology to treat medicinal and edible ingredients, improving the extraction rate and stability of active ingredients. Special dietary formula foods utilize vacuum freeze-drying and low-temperature wall-breaking to preserve the activity of traditional Chinese medicine. Nutritional complex foods utilize conventional pulverization and hot-air drying, meeting daily needs while maintaining cost. Supercritical extraction efficiently extracts heat-sensitive ingredients, nanoencapsulation protects probiotics and heat-sensitive nutrients, and microencapsulation ensures the stability of ingredients like L-carnitine protein, significantly increasing the utilization rate of active ingredients in the products and enhancing their efficacy in regulating lipid metabolism and improving intestinal flora. During the production process, parameters are strictly controlled at each step, and probiotics are encapsulated in varying layers to ensure their survival rate in different products. During processing, low-GI control components undergo precise control of moisture content and degree of expansion through nanofiber extrusion and microwave drying, ensuring stable product quality throughout their shelf life and providing consumers with reliable products.

[0040] Beneficial effects of the present invention:

[0041] The present invention achieves all-round weight management by regulating metabolism through medicinal and edible ingredients, improving intestinal and lipid metabolism through precise nutritional enhancement, controlling and stabilizing blood sugar through low GI, and improving compliance through taste optimization. The proportion of components and process are adjusted according to the degree of obesity to meet the needs of different groups of people and enhance the intervention effect. Supercritical extraction, nano-encapsulation, microencapsulation and other technologies are used to improve the utilization rate and stability of active ingredients, complying with GMP and GB 29922-2013 and other regulatory requirements. The ingredients are selected from the medicinal and edible catalog, and the additives meet national standards. Stability tests have shown that the product has a high active ingredient retention rate during the shelf life and the probiotic survival rate meets the standard. DETAILED DESCRIPTION

[0042] The embodiments of the present invention will be described in detail below with reference to examples. However, those skilled in the art will understand that the following examples are only used to illustrate the present invention and should not be considered to limit the scope of the present invention.

[0043] Example 1

[0044] This embodiment provides a special medical prescription (FSMP) for severe obesity, each bag containing 3.0g of food-medicine group, 3.5g of precise nutrition group, 2.0g of low GI value control group and 1.5g of taste optimization group;

[0045] The food-medicine group includes: radish seeds 0.5g, perilla seeds 0.5g, white mustard seeds 0.3g, wax gourd seeds 0.3g, soap beans 0.2g, safflower seeds 0.2g, corn silk 0.3g, wax gourd peel 0.2g, cassia seeds 0.2g, lotus leaves 0.2g, and tangerine peel 0.1g;

[0046] Precision nutrition group includes: chromium-rich yeast 0.4g (Cr 3+ 200μg), Haematococcus pluvialis (astaxanthin ≥ 3%) 0.3g, L-carnitine protein (purity ≥ 98%) 0.5g, Lactobacillus plantarum LP-Onlly (5×10 8 CFU / g) 0.2g, Bifidobacterium BB-12 (5×10 8 CFU / g) 0.2g, arabinoxylan 1.0g, erythritol 0.3g, polydextrose 0.3g, phospholipids 0.2g and sodium carboxymethylcellulose 0.1g;

[0047] The low GI control group included: oat β-glucan 0.8g, konjac glucomannan 0.7g, and chia seed ultrafine powder 0.5g;

[0048] The taste optimization group included: 0.5g sea buckthorn seed powder, 0.5g lotus seed powder and 0.5g gorgon fruit powder.

[0049] The production process includes the following steps:

[0050] S11. Treatment of the medicine-food homology group:

[0051] The effective components of radish seeds, perilla seeds, white mustard seeds, wax gourd seeds, sapodilla seeds, safflower seeds, corn silk, wax gourd peel, cassia seeds, lotus leaves and tangerine peel were extracted by supercritical CO2 extraction method, and the extraction pressure was 25~

[0052] 35MPa, temperature 40-45℃, extraction time 1.5-2h, and freeze drying at 10Pa vacuum and -50℃ pre-freezing temperature;

[0053] The effective components of Perilla seeds were embedded in sodium alginate-chitosan composite, with a particle size of ≤200nm and an embedding rate of ≥95%.

[0054] The active ingredients of Cassia seed were embedded in β-cyclodextrin, with a mass ratio of β-cyclodextrin to Cassia seed extract of 1:5, an embedding temperature of 50°C, a stirring rate of 300 rpm, and a processing time of 3 h.

[0055] Accurately weigh the extracted effective ingredients of radish seeds, white mustard seeds, wax gourd seeds, sapodilla seeds, safflower seeds, corn silk, wax gourd peel, lotus leaves, and tangerine peel, as well as the perilla seed sodium alginate-chitosan composite embedding material and the cassia seed β-cyclodextrin embedding material and mix them evenly in proportion;

[0056] S12, precision nutrition group treatment:

[0057] L-carnitine protein is microencapsulated by spray drying to produce L-carnitine microcapsules with a particle size of ≤200 nm. The inlet air temperature of the spray drying is 180°C and the outlet air temperature is 80°C. The embedding material is sodium alginate-chitosan, and the embedding rate is ≥95%.

[0058] Lactobacillus plantarum LP-Onlly and Bifidobacterium BB-12 were triple-encapsulated in calcium alginate-chitosan-pectin layers to produce probiotic triple-encapsulated materials with a particle size of ≤500nm and a gastric acid-resistant survival rate of ≥95%;

[0059] Other precise nutritional components are nano-crushed to a particle size of ≤500nm;

[0060] The L-carnitine microcapsules, the probiotic triple-encapsulated material, the chromium-enriched yeast, the Haematococcus pluvialis, the arabinoxylan, the erythritol, the polydextrose, the phospholipids and the sodium carboxymethylcellulose are mixed evenly in proportion;

[0061] S13, low GI value control group treatment:

[0062] The oat β-glucan is extruded and puffed in an extruder until the volume expansion is ≥3 times, the screw speed of the extruder is 200 rpm, the die temperature is 120°C, and the fiber diameter is ≤50 nm;

[0063] Konjac glucomannan was homogenized three times under high pressure of 150 MPa until the particle size was ≤ 50 nm;

[0064] Chia seeds are low-temperature dried at a temperature of 50° C. and a wind speed of 2 m / s to a moisture content of ≤5%, and then ultrafinely ground to a particle size of ≤50 μm to obtain chia seed ultrafine powder;

[0065] The expanded oat β-glucan, homogenized konjac glucomannan and chia seed superfine powder are mixed evenly in proportion;

[0066] S14, taste optimization group processing:

[0067] Extracting flavonoids from seabuckthorn seeds with supercritical CO2 at a pressure of 30 MPa and a temperature of 40° C. (retention rate ≥ 90%), and ultrafinely grinding the seeds into seabuckthorn powder with a particle size of ≤ 50 μm;

[0068] The lotus seeds are baked at 60° C. for 2 h until the moisture content is ≤ 6%, and then ultrafinely ground into lotus seed powder;

[0069] The gorgon fruit is microwave-dried and crushed into gorgon fruit powder;

[0070] Mix seabuckthorn seed powder, lotus seed powder and gorgon fruit powder in proportion;

[0071] S15. Mixing and packaging: Evenly mix the medicine and food group, the precise nutrition group, the low GI control group, and the taste optimization group in a ratio of 30:35:20:15, pack them into aluminum foil bags using nitrogen-filled packaging technology, and seal them for storage.

[0072] Core ingredient testing:

[0073] The detection of core ingredients is a key link in evaluating product quality and efficacy. Taking radish seed sinapine, L-carnitine and astaxanthin as examples, they respectively reflect the product's ability to regulate metabolism, promote fat oxidation and anti-oxidation. The detection method and results are shown in Table 1. The HPLC method (Chinese Pharmacopoeia) was used to detect the content of radish seed sinapine. The standard requires its content to be ≥2.0 mg / g, and the actual detection value is 2.5±0.3 mg / g, indicating that the content of radish seed sinapine in the product is sufficient and can effectively exert its effect of regulating lipid metabolism. Raphanus sativus can promote gastrointestinal motility, aid digestion, and reduce fat accumulation in the body. The measured value is higher than the standard, which means that the product has greater potential in improving obesity-related digestive function and regulating lipid metabolism. The L-carnitine purity was tested according to the GB24154-2015 standard, which requires a purity of ≥98%. The actual purity was 98.5% ± 0.3%. L-carnitine plays a key role in fat metabolism, transporting long-chain fatty acids into the mitochondria for oxidative breakdown, thereby promoting fat burning. The high purity of the L-carnitine in this product ensures its effectiveness in promoting fat oxidation and assisting weight management, providing reliable metabolic support for individuals with obesity and overweight. The astaxanthin content was tested according to the GB 5009.248-2016 standard, which requires a purity of ≥3.0 mg / g. The actual value was 3.8 ± 0.2 mg / g. Astaxanthin has potent antioxidant properties, can reduce inflammation in the body, and protect cells from oxidative damage. Obese and overweight individuals experience a degree of oxidative stress and inflammation. A level of astaxanthin that meets or exceeds the standard can help alleviate these conditions, potentially improving the body's metabolic environment and preventing obesity-related complications.

[0074] Table 1 Core ingredient test results

[0075]

[0076]

[0077] Stability test:

[0078] The stability test mainly includes accelerated tests (40℃ / RH75%, 6 months) and long-term tests (25℃ / 12 months). By monitoring indicators such as L-carnitine retention rate and probiotic survival rate, the quality stability of the product under different storage conditions is evaluated. The test results are shown in Table 2. In the accelerated test, the L-carnitine retention rate is required to be ≥90%. The actual results meet this standard, indicating that under the accelerated aging conditions of high temperature and high humidity, the L-carnitine in the product can maintain a high stability and is not easy to decompose; in the long-term test (25℃ / 12 months), the retention rate is ≥95%, which means that under normal storage conditions, L-carnitine can be stably present in the product for a long time. The stable presence of L-carnitine ensures that the product continues to promote fat metabolism during its shelf life, providing consumers with stable efficacy guarantees. In the accelerated test, the probiotic survival rate is required to be ≥1×108CFU / g. The actual standard is met, indicating that the probiotics in the product can still maintain a high activity under harsh storage conditions; in the long-term test, the survival rate is ≥1.2×10 8 CFU / g indicates that under normal storage conditions, the activity of probiotics is more guaranteed. Probiotics are essential for regulating the balance of intestinal flora and enhancing intestinal barrier function. Probiotics with high survival rates can ensure that the product effectively improves the intestinal microecological environment throughout its shelf life, helping obese and overweight patients maintain intestinal health and promoting the absorption of nutrients and the excretion of metabolic waste.

[0079] Table 2 Stability test results

[0080]

[0081] Example 2

[0082] This embodiment provides a special dietary formula for moderate obesity, each bag containing 2.5g of medicine and food group, 3.5g of precise nutrition group, 2.5g of low GI value control group and 1.5g of taste optimization group;

[0083] The food-medicine group includes: radish seeds 0.4g, perilla seeds 0.4g, white mustard seeds 0.3g, wax gourd seeds 0.3g, soap beans 0.2g, safflower seeds 0.2g, corn silk 0.2g, wax gourd peel 0.1g, cassia seeds 0.2g, lotus leaves 0.1g, and dried tangerine peel 0.1g;

[0084] Precision nutrition group includes: chromium-rich yeast 0.4g (Cr 3+ 200μg), Haematococcus pluvialis (astaxanthin ≥ 3%) 0.3g, L-carnitine protein (purity ≥ 98%) 0.5g, Lactobacillus plantarum LP-Onlly (5×10 8 CFU / g) 0.2g, Bifidobacterium BB-12 (5×10 8CFU / g) 0.2g, arabinoxylan 1.0g, erythritol 0.3g, polydextrose 0.3g, phospholipids 0.2g and sodium carboxymethylcellulose 0.1g;

[0085] The low GI control group included: oat β-glucan 1.2g, konjac glucomannan 0.8g, and chia seed ultrafine powder 0.5g;

[0086] The taste optimization group included: 0.6g sea buckthorn seed powder, 0.5g lotus seed powder and 0.4g gorgon fruit powder.

[0087] The production process includes the following steps:

[0088] S21. Treatment for the edible medicinal group: Radish seeds, white mustard seeds, perilla seeds, sapodilla seeds, safflower seeds, corn silk, wax gourd peel, cassia seed, lotus leaves, and dried tangerine peel were freeze-dried separately and cryopreserved to a particle size of ≤15 μm to obtain cryopreserved freeze-dried powder. The vacuum degree of the freeze-drying process was 20 Pa, the temperature was -45°C, the cryopreservation pressure was 0.8 MPa, and the time was 30 min.

[0089] The active ingredients of wax gourd seeds were extracted by enzymatic hydrolysis with cellulase (dosage 0.5%) at a temperature of 50°C, a pH of 5.0, and a hydrolysis time of 4 h.

[0090] Accurately weigh radish seeds, white mustard seeds, wax gourd seeds, sapodilla seeds, safflower seeds, corn silk, wax gourd peel, lotus leaves, and tangerine peel low-temperature wall-breaking freeze-dried powder and wax gourd seed enzymatic hydrolysis extract and mix them evenly in proportion;

[0091] S22, precision nutrition group treatment:

[0092] Low temperature spray drying of carnitine compounds;

[0093] Probiotics double encapsulation (calcium alginate-chitosan encapsulation, survival rate ≥ 90%) is a probiotics double encapsulation;

[0094] Other precise nutritional components were ultrafinely ground to a particle size of ≤50 μm using a jet mill at a pressure of 0.7 MPa and a classifying wheel speed of 12,000 rpm;

[0095] Arabinxylitol was first dissolved in water at a water-to-material ratio of 1:3, with a stirring rate of 500 rpm and a dissolution temperature of 50°C, and then mixed evenly with other precise nutritional components in proportion;

[0096] S23, low GI control group treatment: water-soluble dietary fiber and slow-release carbohydrates were first low-temperature dried at 50°C and 2 m / s wind speed to a moisture content of ≤5%, ultrafinely ground to a particle size of ≤50 μm, and mixed uniformly according to the proportion;

[0097] S24, taste optimization group treatment: sea buckthorn seeds were supercritical CO2 extracted and ultrafinely ground to a particle size of ≦50 μm to obtain sea buckthorn seed powder; lotus seeds were low-temperature roasted and nano-ground to obtain lotus seed powder; gorgon fruit were microwave-dried and ground to obtain gorgon fruit powder, and the mixture was evenly mixed;

[0098] S25. Mixing and packaging: Evenly mix the medicine and food group, the precision nutrition group, the low GI value control group, and the taste optimization group in the ratio of 25:35:25:15, and vacuum pack.

[0099] Example 3

[0100] This embodiment provides a nutritional compound diet formula for mild obesity (overweight), each bag containing 2.0g of a medicine-food combination group, 3.5g of a precise nutrition group, 3.0g of a low GI control group, and 1.5g of a taste-optimized group;

[0101] The food-medicine group includes: radish seeds 0.3g, perilla seeds 0.3g, white mustard seeds 0.2g, wax gourd seeds 0.2g, soap beans 0.1g, safflower seeds 0.2g, corn silk 0.2g, wax gourd peel 0.2g, cassia seeds 0.1g, lotus leaves 0.1g, and dried tangerine peel 0.1g;

[0102] Precision nutrition group includes: chromium-rich yeast 0.4g (Cr 3+ 200μg), Haematococcus pluvialis (astaxanthin ≥ 3%) 0.3g, L-carnitine protein (purity ≥ 98%) 0.5g, Lactobacillus plantarum LP-Onlly (5×10 8 CFU / g) 0.2g, Bifidobacterium BB-12 (5×10 8 CFU / g) 0.2g, arabinoxylan 1.0g, erythritol 0.3g, polydextrose 0.3g, phospholipids 0.2g and sodium carboxymethylcellulose 0.1g;

[0103] The low GI control group included: oat β-glucan 1.5g, konjac glucomannan 1.0g, and chia seed ultrafine powder 0.5g;

[0104] The taste optimization group included: 0.6g sea buckthorn seed powder, 0.5g lotus seed powder and 0.4g gorgon fruit powder.

[0105] The production process includes the following steps:

[0106] S31, medicine and food homology group treatment:

[0107] Corn silk polysaccharide was extracted by water-alcohol precipitation method with a water-to-solid ratio of 10:1, extraction temperature of 80℃, ethanol concentration of 70%, and precipitation time of 12h.

[0108] Radish seeds, white mustard seeds, perilla seeds, wax gourd seeds, sapodilla seeds, safflower seeds, corn silk polysaccharide, wax gourd peel, cassia seeds, lotus leaves and tangerine peel were respectively ground by a hammer mill and passed through an 80-mesh sieve (particle size ≤ 180 μm), dried with hot air and mixed uniformly according to proportion;

[0109] S32. Precision Nutrition Group Treatment: Probiotics were embedded in the probiotics, and the other precision nutrition group components were crushed and sieved as usual. First, sodium hydroxymethylcellulose was dissolved at a water-to-material ratio of 1:5 (stirring speed 400 rpm, dissolution temperature 40°C). Then, polydextrose and other precision nutrition group components were uniformly mixed with the sodium hydroxymethylcellulose aqueous solution using a double-screw mixer at a speed of 15 rpm for 20 minutes, with a uniformity CV ≤ 5%.

[0110] S33, low GI control group treatment: water-soluble dietary fiber and slow-release carbohydrates were hot-air dried to a moisture content of ≤8%, and then crushed and mixed in proportion;

[0111] S34, taste optimization group treatment: sea buckthorn seeds were supercritical CO2 extracted and ultrafinely ground to a particle size of ≦50 μm to obtain sea buckthorn seed powder; lotus seeds were low-temperature roasted and nano-ground to obtain lotus seed powder; gorgon fruit were microwave-dried and ground to obtain gorgon fruit powder, and the mixture was evenly mixed;

[0112] S35. Mixing and packaging: Evenly mix the medicine and food group, precise nutrition group, low GI control group and taste optimization group in the ratio of 20:35:30:15, and package them to meet the needs of daily nutritional intervention.

[0113] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit them. Those skilled in the art should understand that they can still modify the technical solutions described in the above embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements will not cause the essence of the corresponding technical solutions to deviate from the scope of protection of the present invention.

Claims

1. A special medical and special dietary compound diet formula for obesity and overweight, suitable for preparing special medical food, special dietary food or nutritional compound diet, characterized in that: include: The medicine-food group is composed of medicine-food ingredients with the functions of clearing phlegm and turbidity, promoting dampness and relieving swelling, promoting bowel movements, and regulating qi and relieving stagnation; Precision nutrition group, including ingredients with metabolic regulation and intestinal microecological regulation functions and functional additives; The low GI control group consisted of water-soluble dietary fiber and slow-release carbohydrates; Taste optimization group, consisting of natural sweeteners and taste modifiers; The prescription is designed according to the degree of obesity: For severe obesity, the proportion of medicinal and edible components is 30wt%, the proportion of precise nutrition components is 35wt%, the proportion of low GI value control components is 20wt%, and the proportion of taste optimization components is 15wt%; For moderate obesity, the proportion of medicinal and edible components is 25wt%, the proportion of precise nutrition components is 35wt%, the proportion of low GI value control components is 25wt%, and the proportion of taste optimization components is 15wt%; For mild obesity, the proportion of medicinal and edible components is 20wt%, the proportion of precise nutrition components is 35wt%, the proportion of low GI value control components is 30wt%, and the proportion of taste optimization components is 15wt%.

2. The special medical and dietary compound formula for obesity and overweight according to claim 1, characterized in that: The medicine and food group includes radish seeds, white mustard seeds, perilla seeds, wax gourd seeds, soapberry seeds, safflower seeds, corn silk, wax gourd peel, cassia seeds, lotus leaves and tangerine peel.

3. The special medical and dietary compound formula for obesity and overweight according to claim 2, characterized in that: The ingredients with metabolic regulation function include trace elements, carotenoids and carnitine compounds; the ingredients with intestinal microecological regulation function include probiotics and prebiotics; and the functional additives include natural sweeteners, emulsifiers and stabilizers.

4. The special medical and dietary compound formula for obesity and overweight according to claim 3, characterized in that: The water-soluble dietary fiber includes beta-glucan and glucomannan; and the slow-release carbohydrate includes chia seeds.

5. The special medical and dietary compound formula for obesity and overweight according to claim 4, characterized in that: The natural sweeteners include seabuckthorn seed powder and lotus seed powder; the taste regulator includes gorgon fruit powder.

6. The production process of the special medical and special dietary compound meal for obesity and overweight according to claim 5, characterized in that: The following steps are involved: Treatment of the medicine-food group: Supercritical CO2 extraction was used to extract the active ingredients of radish seeds, perilla seeds, white mustard seeds, wax gourd seeds, sapodilla seeds, safflower seeds, corn silk, wax gourd peel, cassia seeds, lotus leaves and tangerine peel, and the active ingredients of perilla seeds and cassia seeds were nano-encapsulated respectively; Precision Nutrition Group Treatment: Carnitine compounds were encapsulated using microencapsulation technology to produce carnitine compound microcapsules with a particle size of ≤200nm; triple-encapsulated probiotics were encapsulated with a particle size of ≤500nm, and other precision nutrition group components were nano-crushed to a particle size of ≤500nm; Low GI control group treatment: water-soluble dietary fiber was extruded or homogenized under high pressure, and slow-release carbohydrates were ultrafinely ground into ultrafine powder; Taste optimization group treatment: Sea buckthorn seeds were supercritical CO2 extracted and ultrafinely ground to a particle size of ≦50μm to obtain sea buckthorn seed powder; lotus seeds were low-temperature roasted and nano-ground to obtain lotus seed powder; gorgon fruit were microwave-dried and ground to obtain gorgon fruit powder; Mixing and packaging: the medicine and food group, the precision nutrition group, the low GI value control group and the taste optimization group are mixed evenly in proportion according to the degree of obesity, and aseptically sealed and packaged.

7. The production process of the special medical and special dietary compound meal for obesity and overweight according to claim 5, characterized in that: The following steps are involved: Treatment of the food-medicine group: Radish seeds, white mustard seeds, perilla seeds, wax gourd seeds, sapodilla seeds, safflower seeds, corn silk, wax gourd peel, cassia seeds, lotus leaves, and tangerine peel were freeze-dried separately and then broken at low temperature to a particle size of ≤15 μm; Precision nutrition group treatment: carnitine compounds were spray-dried at low temperature; probiotics were double-encapsulated, and other precision nutrition group components were ultrafinely ground to a particle size of ≤50μm; Low GI control group treatment: water-soluble dietary fiber and slow-release carbohydrates were low-temperature dried to a moisture content of ≤5% and ultrafinely ground; Taste optimization group treatment: Sea buckthorn seeds were supercritical CO2 extracted and ultrafinely ground to a particle size of ≦50μm to obtain sea buckthorn seed powder; lotus seeds were low-temperature roasted and nano-ground to obtain lotus seed powder; gorgon fruit were microwave-dried and ground to obtain gorgon fruit powder; Mixing and packaging: the medicine and food group, the precision nutrition group, the low GI value control group and the taste optimization group are mixed evenly in proportion according to the degree of obesity, and aseptically sealed and packaged.

8. The production process of the special medical and special dietary compound meal for obesity and overweight according to claim 5, characterized in that: The following steps are involved: Treatment of the edible and medicinal group: radish seeds, white mustard seeds, perilla seeds, wax gourd seeds, sapodilla seeds, safflower seeds, corn silk, wax gourd peel, cassia seeds, lotus leaves, and tangerine peel were crushed separately and passed through an 80-mesh sieve, and dried with hot air; Precision nutrition group processing: probiotics are embedded into probiotics, and other precision nutrition group components are crushed and sieved in ordinary way; Low GI control group treatment: water-soluble dietary fiber and slow-release carbohydrates were hot-air dried to a moisture content of ≤8%, then crushed and sieved; Taste optimization group treatment: Sea buckthorn seeds were supercritical CO2 extracted and ultrafinely ground to a particle size of ≦50μm to obtain sea buckthorn seed powder; lotus seeds were low-temperature roasted and nano-ground to obtain lotus seed powder; gorgon fruit were microwave-dried and ground to obtain gorgon fruit powder; Mixing and packaging: the medicine and food group, the precision nutrition group, the low GI value control group and the taste optimization group are mixed evenly in proportion according to the degree of obesity, and aseptically sealed and packaged.

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