Anti-inflammatory healing-promoting electrospinning wound dressing as well as preparation method and application thereof

Through the anti-inflammatory pro-healing electrospin wound dressing with a double-layer structure, the use of temperature-sensitive gelatin to respond to the temperature changes of wound inflammation, the controlled release of drugs and the management of exudate is achieved, which solves the problems of uncontrollable drug release and poor exudate management in chronic wounds, and promotes wound healing.

CN120437352AActive Publication Date: 2025-08-08CHANGCHUN UNIV OF TECH
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Patent Information

Application Number
CN202510954074.7
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-07-11
Publication Date
2025-08-08
Estimated Expiration
2045-07-11

AI Technical Summary

Technical Problem

Existing wound dressings are uncontrollable in chronic difficult-to-heal wounds, making it difficult to meet the long-term anti-inflammatory and healing needs, and the exudate is poorly managed.

Method used

The anti-inflammatory pro-healing electrospin wound dressing with a double-layer structure is a hydrophilic nanofiber membrane prepared by electrospinning with a single nozzle, and the inner layer is a core-shell structure nanofiber membrane prepared by coaxial electrospinning. The core layer contains temperature-sensitive gelatin, healing growth factors and anti-inflammatory drugs, so that the controlled release of drugs can be achieved through temperature changes.

Benefits of technology

It realizes accurate drug delivery on demand, efficient management of exudate, promotes wound healing, and solves the problem of uncontrollable release of traditional dressings.

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Abstract

The invention discloses an anti-inflammatory healing-promoting electrospinning wound dressing and a preparation method and application thereof, and belongs to the technical field of medical dressings. Wherein the outer layer is a hydrophilic nanofiber membrane prepared by adopting single-nozzle electrostatic spinning and is used for absorbing wound exudate; the inner layer is a nanofiber membrane which is of a core-shell structure and prepared by coaxial electrostatic spinning, and a shell layer of the core-shell structure is made of a hydrophobic material and is used for guiding percolate to the outer layer; the core layer of the core-shell structure comprises hydrophilic temperature-sensitive macromolecules, healing-promoting growth factors and anti-inflammatory drugs; the shell layer has hydrophobicity and is used for guiding wound exudate to the hydrophilic nanofiber membrane on the outer layer; when the local temperature caused by wound inflammation is greater than or equal to 37 DEG C, the temperature change causes the drug-loaded temperature-sensitive phase change macromolecules to generate different degrees of phase change, so that the timely and controllable release of the drug is realized, and the healing of the wound surface is ensured.
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