Gel factor and application thereof

Abstract

The invention provides a compound which is novel in structure and is shown in a formula (I), the compound can be used as a gelator, various solvents can be gelatinized at low concentration, and the gel forming speed is high. The compound has significantly lower critical gel concentration in different solvents, and has more excellent mechanical properties. Meanwhile, the compound can be synthesized by utilizing a click chemical reaction, is simple in structure, convenient to prepare and high in yield, and can be prepared on a large scale. The invention provides application of a compound as shown in a formula (II) as a gelator and gel containing the compound as shown in the formula (II). The compound has significantly lower critical gel concentration in different solvents, and has more excellent mechanical properties.

Description

Technical Field

[0001] The invention belongs to the technical field of supramolecular chemistry, and particularly relates to a type of gel factor and application thereof. Background Art

[0002] Low molecular-mass organogelators (LMOGs) have attracted significant interest due to their self-assembly behavior from the molecular to micrometer scale, forming fibrous network structures and the physicochemical properties of the resulting thermoreversible gels. Below the gelation temperature, LMOGs aggregate into structures such as fibers, strands, and ribbons through hydrogen bonding, π-π stacking, van der Waals forces, ion-ion interactions, and host-guest interactions. These structures connect at "nodes" to form networks, immobilizing liquids through surface tension and capillary forces. If the immobilized liquid is water, a hydrogel forms; if the immobilized liquid is an organic solvent, an organogel forms. Organogels can be divided into non-fluorinated gels and fluorinated gels depending on the type of immobilizing solvent.

[0003] Numerous literature reports on LMOGs that can form hydrogels and non-fluorinated organogels, along with their applications in smart wearables, biomedicine, and optoelectronic displays, have been published. However, fluorinated solvents are difficult to gel due to their low surface tension, poor solubility for organic molecules, low cohesive energy, and high volatility. Consequently, relatively few reports on fluorinated gels exist.

[0004] Fluorine solvents are biologically inert, thermally stable, chemically stable, and highly soluble in gases such as oxygen and carbon dioxide. If a fluorine gel constructed with a non-hydrogen bond network that undergoes a gel-sol transition at room temperature or near body temperature can be obtained, it is expected to be used in wound dressings, blood substitutes, oxygen or drug delivery systems, cell culture matrices, photodynamic therapy, industrial treatment of fluorine-containing waste liquids, and safe transportation of fluorine solvents. Summary of the Invention

[0005] The purpose of the present invention is to provide a type of gel factor and application thereof.

[0006] The present invention provides a compound represented by formula (I):

[0007]

[0008] wherein m1 is an integer selected from 6-22, n1 is an integer selected from 2-12, and p1 is an integer selected from 1-6.

[0009] According to an embodiment of the present invention, m1 is an integer selected from 8-20, for example 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20.

[0010] According to an embodiment of the present invention, n1 is an integer selected from 4-10, such as 4, 5, 6, 7, 8, 9, 10.

[0011] According to an embodiment of the present invention, p1 is an integer selected from 1-4, such as 1, 2, 3, 4.

[0012] According to an embodiment of the present invention, the compound represented by formula (I) has the following structure:

[0013]

[0014] The present invention also provides the use of the compound represented by the above formula (I) and the compound represented by the following formula (II) as a gel factor or in the preparation of a gel factor;

[0015]

[0016] wherein m2 is an integer selected from 6-22, n2 is an integer selected from 2-12, and p2 is an integer selected from 1-6.

[0017] According to an embodiment of the present invention, m2 is an integer selected from 8-20, for example 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20.

[0018] According to an embodiment of the present invention, n2 is an integer selected from 4-10, such as 4, 5, 6, 7, 8, 9, 10.

[0019] According to an embodiment of the present invention, p2 is an integer selected from 1-4, such as 1, 2, 3, 4.

[0020] According to an embodiment of the present invention, the compound represented by formula (II) has the following structure:

[0021]

[0022] The present invention also provides a gel factor, which comprises the compound represented by the above formula (I) or formula (II).

[0023] The present invention also provides a gel, which comprises the compound represented by the above formula (I) or the compound represented by the above formula (II) or the above gel factor and a solvent.

[0024] According to an embodiment of the present invention, in the gel, the content of the compound represented by formula (I) or the compound represented by formula (II) or the above-mentioned gel factor is greater than or equal to the critical gel concentration, for example, 0.07%, 0.1%, 0.15%, 0.2%, 0.3%, 0.4%, 0.5%, 0.7%, 1.0%, 1.5%, 2.0%, 3.0%, 4.0%, 10%.

[0025] According to an embodiment of the present invention, the solvent is selected from a non-fluorinated organic solvent and a fluorinated organic solvent. According to an embodiment of the present invention, the non-fluorinated organic solvent is selected from a medium-polarity organic solvent and a strong-polarity organic solvent. According to an embodiment of the present invention, the fluorinated organic solvent is selected from a non-polar perfluorinated solvent and a medium-polarity fluorinated solvent. According to an embodiment of the present invention, the fluorinated organic solvent is selected from a perfluorinated organic solvent and a high-fluorinated organic solvent.

[0026] According to an embodiment of the present invention, the solvent is selected from medium polarity to strong polarity non-fluorine organic solvents (such as methanol, ethanol, n-butanol, acetonitrile, N,N-dimethylamide, dimethyl carbonate, dimethyl sulfoxide, propylene carbonate, etc.), non-polar to medium polarity fluorine-containing solvents (such as hexafluoropropylene trimer, perfluorodecalin, perfluorotributylamine, perfluorooctane, nonafluorobutyl methyl ether, perfluorooctyl bromide, etc.).

[0027] According to an embodiment of the present invention, the solvent is selected from hexafluoropropylene trimer, perfluorodecalin, perfluorooctane, perfluorotributylamine, propylene carbonate, dimethyl sulfoxide, methanol, N,N-dimethylformamide, and acetonitrile.

[0028] According to an embodiment of the present invention, the gel is selected from fluorine-containing organic gel and non-fluorine organic gel.

[0029] According to an embodiment of the present invention, the gel comprises the compound LMOG-1 and a solvent; preferably, the solvent is selected from hexafluoropropylene trimer, perfluorooctane, perfluorodecalin, perfluorotributylamine, propylene carbonate, and dimethyl sulfoxide.

[0030] According to an embodiment of the present invention, the gel comprises the compound LMOG-2 and a solvent; preferably, the solvent is selected from hexafluoropropylene trimer, perfluorodecalin, perfluorooctane, perfluorotributylamine, propylene carbonate, dimethyl sulfoxide, and N,N-dimethylformamide.

[0031] According to an embodiment of the present invention, the gel comprises the above-mentioned compound LMOG-3 and a solvent; preferably, the solvent is selected from hexafluoropropylene trimer, perfluorodecalin, perfluorooctane, perfluorotributylamine, propylene carbonate, dimethyl sulfoxide, N,N-dimethylformamide, and acetonitrile.

[0032] According to an embodiment of the present invention, the gel comprises the compound LMOG-4 and a solvent; preferably, the solvent is selected from perfluorooctane, propylene carbonate, dimethyl sulfoxide, N,N-dimethylformamide, and acetonitrile.

[0033] According to an embodiment of the present invention, the gel comprises the compound LMOG-5 and a solvent; preferably, the solvent is selected from perfluorooctane, propylene carbonate, N,N-dimethylformamide, and acetonitrile.

[0034] According to an embodiment of the present invention, the gel comprises the compound LMOG-6 and a solvent; preferably, the solvent is selected from N,N-dimethylformamide and acetonitrile.

[0035] According to an embodiment of the present invention, the gel comprises the compound LMOG-7 and a solvent; preferably, the solvent is selected from hexafluoropropylene trimer, perfluorodecalin, perfluorotributylamine, N,N-dimethylformamide, acetonitrile, and methanol.

[0036] The present invention also provides the use of the compound represented by the above formula (I), the above gel factor, and the above gel in the preparation of wound dressings, blood substitutes, oxygen or drug delivery preparations, cell culture matrices, photodynamic therapy agents, fluorine-containing waste liquid treatment agents, and gas (such as oxygen, carbon dioxide) storage agents.

[0037] The present invention also provides a method for preparing the gel, which comprises the following steps:

[0038] The above compounds or gel factors are dissolved in a solvent and allowed to stand to form a gel.

[0039] According to an embodiment of the present invention, the dissolution of the fluorine-containing gelling factor and the solvent may be promoted by heating or ultrasound.

[0040] The present invention also provides a method for preparing the compound represented by the above formula (I), which is as follows:

[0041] The compound represented by formula (I) is prepared by reacting the compound represented by formula (I-1) and the compound represented by formula (I-2) in the presence of a basic substance;

[0042]

[0043] Wherein, m1, n1, and p1 have the aforementioned definitions.

[0044] According to an embodiment of the present invention, the alkaline substance is selected from organic amine alkaline substances (such as trimethylamine, triethylamine, pyridine, aniline, etc.) and inorganic alkaline substances (such as KOH, NaOH, Na2CO3, K2CO3, etc.). All alkaline substances or alkaline reagents that undergo thiol click chemistry according to the Michael addition mechanism can be used in this reaction.

[0045] According to an embodiment of the present invention, the reaction is carried out in a solvent; preferably, the solvent is selected from polar protic solvents (such as methanol, ethanol, etc.), polar aprotic solvents (such as dimethyl sulfoxide, N,N-dimethylformamide, etc.), and weakly polar solvents (such as dichloromethane, toluene, etc.). All solvents that carry out thiol click chemistry reactions according to the Michael addition mechanism can be used in this reaction.

[0046] According to an embodiment of the present invention, the reaction temperature is room temperature to 50°C.

[0047] Beneficial effects:

[0048] 1) The present invention provides a novel compound represented by formula (I). This compound can act as a gelling agent, capable of gelling a variety of solvents (including both fluorinated and non-fluorinated solvents) at low concentrations. The gel formation rate is rapid, and the compound exhibits significantly lower critical gel concentrations in different solvents, resulting in superior mechanical properties. Furthermore, the compound can be synthesized using click chemistry, exhibiting a simple structure, convenient preparation, high yield, and the ability to be produced in large quantities.

[0049] 2) The present invention also provides the use of the compound represented by formula (II) as a gelling agent, and a gel comprising the compound represented by formula (II). The compound has a significantly lower critical gel concentration in different solvents and has better mechanical properties. BRIEF DESCRIPTION OF THE DRAWINGS

[0050] Figure 1 It is the compound LMOG-1 1 H NMR spectrum.

[0051] Figure 2 It is the compound LMOG-7 1 H NMR spectrum.

[0052] Figure 3 This is the rheological property test result of the gel. DETAILED DESCRIPTION

[0053] The technical solutions of the present invention will be described in further detail below with reference to specific embodiments. It should be understood that the following embodiments are merely illustrative and explanations of the present invention and should not be construed as limiting the scope of protection of the present invention. All technologies implemented based on the above content of the present invention are encompassed within the scope of protection that the present invention is intended to protect.

[0054] Unless otherwise specified, the raw materials and reagents used in the following examples are commercially available or can be prepared by known methods.

[0055] The following is a further description of the fluorine-containing LMOG and the preparation methods of the fluorine gel and organogel of the present invention through specific examples.

[0056] Example 1 Preparation of LMOG-1

[0057] LMOG-1, its structural formula is as follows:

[0058]

[0059] The synthetic route of LMOG-1 is as follows:

[0060]

[0061] The preparation method of compound LMOG-1 comprises the following steps:

[0062] 4 mL (16.6 mmol) of dodecanethiol, 1.68 g of triethylamine (16.6 mmol), and 50 mL of dichloromethane were placed in a single-necked flask and stirred at room temperature for 20 minutes. Then, 8.62 g (16 mmol) of perfluorooctyl ethyl acrylate was added. After reacting at room temperature for 24 hours, dichloromethane and triethylamine were removed by rotary evaporation. The remaining material was added to petroleum ether, filtered, and then rotary evaporation was performed to remove petroleum ether to obtain 11 g of product with a yield of 92%.

[0063] LMOG-1(CH3-(CH2) 11 -S-CH2-CH2-CO-O-CH2-CH2-(CF2)7-CF3) 1 H NMR spectrum Figure 1 shown.

[0064] Example 2 Preparation of Fluorogel from Compound LMOG-1 and Hexafluoropropylene Trimer

[0065] 9 mg of compound LMOG-1 and 1 mL (1.80 g) of hexafluoropropylene trimer were placed in a 2 mL vial and sonicated to dissolve the product. After standing at room temperature for 2 minutes, the entire solution became opaque. When the vial was inverted, the hexafluoropropylene trimer did not migrate, indicating successful gel formation.

[0066] Example 3 Preparation of compounds LMOG-2 to LMOG-6

[0067] Compounds LMOG-2, LMOG-3, LMOG-4, LMOG-5, and LMOG-6 were prepared by referring to the preparation method of compound LMOG-1 in Example 1. The specific structures of compounds LMOG-2, LMOG-3, LMOG-4, LMOG-5, and LMOG-6 are shown in Table 1.

[0068] Table 1 Structures of compounds LMOG-1 to LMOG-6

[0069]

[0070]

[0071] Example 4 Determination of critical gel concentration of compound LMOG-1 in different solvents

[0072] The inverted sample bottle method is used to determine the formation of gel: the test compound and solvent are heated to dissolve and cooled and allowed to stand for a period of time, and then the sample bottle is inverted; if the material in the bottle does not flow and remains at the bottom of the bottle, it can be considered that a gel has formed.

[0073] The measurement results are shown in Tables 2-3. Table 2 is the CGC comparison results (at 20°C) of compound LMOG-1 in different solvents, and Table 3 is the CGC comparison results (at 20°C) of compounds LMOG-1 to LMOG-6 in different solvents.

[0074] Table 2 Critical gel concentration (CGC) of compound LMOG-1 in different solvents

[0075]

[0076] Note: P means that LMOG forms a precipitate in the solvent and cannot form a gel.

[0077] Table 3 Critical gel concentration (CGC) of compounds LMOG-1 to LMOG-6 in different solvents

[0078]

[0079] Note: S means that no gel is formed when the mass concentration increases to 10wt%; P means that LMOG forms a precipitate in the solvent and cannot form a gel.

[0080] As shown in Table 2, the compound LMOG-1 prepared in the present application can gelate dimethyl sulfoxide with extremely high efficiency, while the comparative example compound 1-2 cannot gelate dimethyl sulfoxide and forms a precipitate. Furthermore, the compound LMOG-1 prepared in the present application has a significantly lower critical gelation concentration than the comparative example compound 1-2 in various solvents, indicating that its gelation ability is significantly improved.

[0081] As shown in Table 3, the compounds LMOG-1 to LMOG-6 prepared in the present application can form gels in a variety of fluorinated solvents and organic solvents; among them, LMOG-1 and LMOG-3 have excellent gelation ability.

[0082] Example 5 Preparation of Compound LMOG-7

[0083] The compound LMOG-7 has the following structural formula:

[0084]

[0085] The synthetic route of compound LMOG-7 is as follows:

[0086]

[0087] The preparation method of compound LMOG-7 comprises the following steps:

[0088] 4.3 mL (14 mmol) of hexadecanethiol, 0.56 g of sodium hydroxide (14 mmol), 8 g of perfluorooctylethyl iodide (14 mmol), and 50 mL of tert-butanol were placed in a single-necked flask and reacted at 80 ° C for 3 h. The tert-butanol was removed by rotary evaporation, and the remaining material was dissolved in chloroform, filtered, and then rotary evaporation was performed to remove chloroform to obtain 9.8 g of product with a yield of 72%.

[0089] Compound LMOG-7(CH3-(CH2) 15 -S-CH2-CH2-(CF2)7-CF3) 1 H NMR spectrum Figure 2 shown.

[0090] Example 6 Preparation of Fluorogel from Compound LMOG-7 and Perfluorotributylamine

[0091] 9 mg of compound LMOG-7 and 1 mL (1.8 g) of perfluorotributylamine were placed in a 2 mL vial and heated to dissolve the product. After standing at room temperature for 3 minutes, the solution became opaque. When the vial was inverted, the perfluorotributylamine did not migrate, indicating successful gel formation.

[0092] Example 7 Determination of critical gel concentration of compound LMOG-7 in different solvents

[0093] The critical gel concentration (CGC) of compound LMOG-7 in different solvents was determined by referring to the method of Example 4. The results are shown in Table 4, which shows the CGC comparison results of compound LMOG-7 in different solvents.

[0094] Table 4 Critical gel concentration (CGC) of compound LMOG-7 in different solvents

[0095]

[0096]

[0097] As can be seen from Table 4, the compound LMOG-7 prepared in the present application has a significantly lower critical gel concentration in different solvents compared to the comparative example compound 1-2, that is, the gel ability is significantly improved.

[0098] Example 8 Study on the thermal stability of gel

[0099] Preparation of gels: Gels were prepared with reference to Example 2, specifically, a perfluorotributylamine gel with a LMOG-1 content of 1.5 wt%, designated FC-LMOG-1; a perfluorotributylamine gel with a LMOG-3 content of 1.5 wt%, designated FC-LMOG-3; a perfluorodecalin gel with a LMOG-1 content of 1.5 wt%, designated PFD-LMOG-1; and a perfluorodecalin gel with a LMOG-3 content of 1.5 wt%, designated PFD-LMOG-3.

[0100] The gel transition temperatures (Tg) of the four gels were measured using DSC. The test temperature range was 0-60°C, and the heating and cooling rate was 5°C / min. The results are shown in Table 5.

[0101] Table 5 Tg values of four perfluorogels

[0102] Gel Type Tg(℃) FC-LMOG-1 38.2 FC-LMOG-3 38.5 PFD-LMOG-1 35.2 PFD-LMOG-3 32.1

[0103] The data in Table 5 show that the Tg values of FC-LMOG-1 and FC-LMOG-3 are slightly higher than human body temperature, close to the temperature of cancer cells. Furthermore, perfluorotributylamine has good oxygen solubility and is biologically inert. Therefore, FC-LMOG-1 and FC-LMOG-3 gels can serve as oxygen sources in photodynamic therapy. When near cancer cells, they dissolve and release oxygen, enhancing the efficacy of photodynamic therapy and killing cancer cells. PFD-LMOG-1 and PFD-LMOG-3, on the other hand, have gel transition temperatures above room temperature but below body temperature. At room temperature, they can store gases such as oxygen and carbon dioxide, which can be released by heating them with the palm of your hand when needed.

[0104] Example 9 Rheological properties test

[0105] Preparation of gel: Gels were prepared with reference to Examples 2 and 6, specifically, LMOG-1, LMOG-7, Comparative Example 1, and Comparative Example 2 containing 1.5 wt% perfluorotributylamine gels, which were designated as FC-LMOG-1, FC-LMOG-7, FC-Comparative Example 1, and FC-Comparative Example 2, respectively.

[0106] The oscillation experiment was carried out at 20°C. First, a strain sweep was performed at 1 Hz with a strain range of 0.01 to 100% to obtain the linear viscoelastic range of the gel; then a frequency sweep was performed within the linear viscoelastic range with a frequency range of 0.01 to 100 rad / s. The results are shown in Figure 2. Figure 3 shown.

[0107] from Figure 3 As can be seen from Figure (a), FC-LMOG-1 has the highest elastic modulus G' and loss modulus G", G' reaches 10 4Pa order of magnitude, the linear viscoelastic range is 0.01-1%. The modulus value is followed by FC-LMOG-7, with a linear viscoelastic range of 0.01-0.2%. However, there is no linear viscoelastic range in FC-Comparative Example 1, indicating that the resistance of the gel formed in Comparative Example 1 to strain stimulation is poor; G' and G" of FC-Comparative Example 2 are the smallest. Similarly, Figure 3 (b) It can be seen that FC-LMOG-1 has the highest elastic modulus G' and loss modulus G". The above results show that the gels formed by LMOG-1 and LMOG-7 provided by the present invention have better mechanical properties.

[0108] The above describes the embodiments of the present invention. However, the present invention is not limited to the above embodiments. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention shall be included in the scope of protection of the present invention.

Claims

1. A compound represented by formula (I): in, m1 is an integer selected from 6-22, n1 is an integer selected from 2-12, and p1 is an integer selected from 1-6.

2. The compound according to claim 1, characterized in that m1 is an integer selected from 8-20; Preferably, n1 is an integer selected from 4-10; Preferably, p1 is an integer selected from 1-4; Preferably, the compound represented by formula (I) has the following structure:

3. Use of the compound represented by formula (I) according to claim 1 or 2 and the compound represented by formula (II) as a gel factor or in the preparation of a gel factor; in, m2 is an integer selected from 6-22, n2 is an integer selected from 2-12, and p2 is an integer selected from 1-6.

4. The use according to claim 3, characterized in that m2 is an integer selected from 8-20; Preferably, n2 is an integer selected from 4-10; Preferably, p2 is an integer selected from 1-4; Preferably, the compound represented by formula (II) has the following structure:

5. A gel factor, comprising the compound represented by formula (I) according to any one of claims 1 to 2, or the compound represented by formula (II) according to any one of claims 3 to 4.

6. A gel comprising the compound represented by formula (I) according to any one of claims 1 to 2, or the compound represented by formula (II) according to any one of claims 3 to 4, or the gelator according to claim 5, and a solvent.

7. The gel according to claim 6, characterized in that In the gel, the content of the compound represented by formula (I) according to any one of claims 1 to 2, or the compound represented by formula (II) according to any one of claims 3 to 4, or the gelling factor according to claim 5 is greater than or equal to the critical gel concentration; Preferably, the solvent is selected from non-fluorinated organic solvents and fluorinated organic solvents; preferably, the non-fluorinated organic solvent is selected from medium-polarity organic solvents and strong-polarity organic solvents; preferably, the fluorinated organic solvent is selected from non-polar perfluorinated solvents and medium-polarity fluorinated solvents; Preferably, the solvent is selected from non-fluorinated organic solvents of medium to strong polarity (such as methanol, ethanol, n-butanol, acetonitrile, N,N-dimethylformamide, dimethyl carbonate, dimethyl sulfoxide, propylene carbonate, etc.), non-polar to medium polarity fluorinated solvents (such as hexafluoropropylene trimer, perfluorodecalin, perfluorotributylamine, perfluorooctane, nonafluorobutyl methyl ether, perfluorooctyl bromide, etc.); preferably, the solvent is selected from hexafluoropropylene trimer, perfluorodecalin, perfluorooctane, perfluorotributylamine, propylene carbonate, dimethyl sulfoxide, methanol, N,N-dimethylformamide, acetonitrile; Preferably, the gel is selected from fluorine-containing organic gel and non-fluorine organic gel; Preferably, the gel comprises the compound LMOG-1 and a solvent; preferably, the solvent is selected from hexafluoropropylene trimer, perfluorooctane, perfluorodecalin, perfluorotributylamine, propylene carbonate, and dimethyl sulfoxide; Preferably, the gel comprises the compound LMOG-2 and a solvent; preferably, the solvent is selected from hexafluoropropylene trimer, perfluorodecalin, perfluorooctane, perfluorotributylamine, propylene carbonate, dimethyl sulfoxide, and N,N-dimethylformamide; Preferably, the gel comprises the compound LMOG-3 and a solvent; preferably, the solvent is selected from hexafluoropropylene trimer, perfluorodecalin, perfluorooctane, perfluorotributylamine, propylene carbonate, dimethyl sulfoxide, N,N-dimethylformamide, and acetonitrile; Preferably, the gel comprises the compound LMOG-4 and a solvent; preferably, the solvent is selected from perfluorooctane, propylene carbonate, dimethyl sulfoxide, N,N-dimethylformamide, and acetonitrile; Preferably, the gel comprises the above-mentioned compound LMOG-5 and a solvent; preferably, the solvent is selected from perfluorooctane, propylene carbonate, N,N-dimethylformamide, and acetonitrile; Preferably, the gel comprises the above-mentioned compound LMOG-6 and a solvent; preferably, the solvent is selected from N,N-dimethylformamide and acetonitrile; Preferably, the gel comprises the compound LMOG-7 and a solvent; preferably, the solvent is selected from hexafluoropropylene trimer, perfluorodecalin, perfluorotributylamine, N,N-dimethylformamide, acetonitrile, and methanol.

8. Use of the compound represented by formula (I) according to any one of claims 1 to 2, or the compound represented by formula (II) according to any one of claims 3 to 4, or the gel factor according to claim 5, or the gel according to any one of claims 6 to 7 in the preparation of wound dressings, blood substitutes, oxygen or drug delivery preparations, cell culture matrices, photodynamic therapy agents, fluorine-containing waste liquid treatment agents, and gas storage agents.

9. A method for preparing the gel according to any one of claims 6 to 7, comprising the following steps: The compound represented by formula (I) according to any one of claims 1 to 2, or the compound represented by formula (II) according to any one of claims 3 to 4, or the gelling factor according to claim 5 and a solvent are dissolved and allowed to stand to form a gel.

10. A method for preparing the compound of formula (I) according to any one of claims 1 to 2, wherein the method is as follows: The compound represented by formula (I-1) and the compound represented by formula (I-2) are reacted in the presence of a basic substance to prepare the compound represented by formula (I); in, m1, n1, and p1 have the definitions described in any one of claims 1-2.

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