Chinese and western medicine compound emulsion in water for treating bromhidrosis and preparation method thereof

Abstract

The invention discloses a Chinese and western medicine compound emulsion in water for treating bromhidrosis and a preparation method thereof, and belongs to the technical field of bromhidrosis treatment preparations. The emulsion in water is prepared from the following components in parts by weight: 50 to 200 parts of butter, 600 to 800 parts of disinfectant, 80 to 200 parts of emulsifier, 50 to 150 parts of fungicide, 10 to 40 parts of traditional Chinese medicine powder and 100 to 300 parts of carbonized hair. Various plant extracts are added into the butter, so that the butter has the effects of moistening and relieving sensitivity; the disinfectant takes ethanol and n-propyl alcohol as main components; the emulsifier contains antibacterial components such as trifluorohydroxydiphenyl ether and trichloro hydroxydiphenyl ether, and a surfactant; the fungicide is ketoconazole cream; the traditional Chinese medicine powder is composed of borneol, coptis chinensis powder, alum and the like and has the effects of clearing heat, drying dampness, astringing and inhibiting bacteria. Crinis carbonisatus reduces peculiar smell precursors through physical adsorption, medicine permeation is enhanced through extraneous protein, and no irritation is caused to the skin. The emulsion in water is clear in texture and easy to absorb, multiple antibacterial barriers are constructed through the synergistic effect of Chinese and western medicines, and the emulsion in water has the functions of efficient bacteriostasis, lasting effect and skin protection.

Description

Technical Field

[0001] The invention belongs to the technical field of axillary odor treatment preparations, and in particular relates to a Chinese and Western medicine compound aqueous emulsion for treating axillary odor and a preparation method thereof. Background Art

[0002] Bromhidrosis, also known as body odor, is a common, localized abnormal body odor disorder. It is primarily caused by the secretion of fatty acids and proteins from the apocrine sweat glands (large sweat glands) in the armpits. These substances, when broken down on the skin by microorganisms such as Staphylococcus aureus and Corynebacterium, produce volatile substances (such as short-chain fatty acids and ammonia compounds) with a distinctive odor. Its onset is closely related to genetics, endocrine function, local hygiene, and microbial flora imbalance. Clinically, it manifests as a pungent, unpleasant odor emanating from the armpits, which is particularly exacerbated by heat, exercise, or emotional stress. While not a direct health hazard, bromhidrosis can easily lead to low self-esteem and social difficulties in patients, severely impacting their quality of life.

[0003] Currently, the treatment methods for axillary odor mainly include the following categories:

[0004] Topical medications often aim to inhibit bacteria, provide astringency, and stop sweating. Common ingredients, such as ethanol, alum, salicylic acid, and aluminum salts, reduce odor by inhibiting bacterial growth or reducing sweat secretion. However, traditional topical preparations, mostly in the form of aqueous solutions or creams, have significant drawbacks: the active ingredients in aqueous solutions are volatile, requiring frequent application and exhibiting a short duration of action; creams or emulsions are greasy, sticky, and have poor breathability. Long-term use can clog pores or trigger skin allergies, particularly in the sensitive underarm area, where redness, swelling, dryness, and other discomforts can occur.

[0005] Surgical treatment: such as axillary sweat gland resection and minimally invasive surgery, which can achieve the purpose of radical cure by destroying or removing the apocrine sweat glands. However, the surgery is very traumatic and has a long recovery period. It may leave scars and there are risks of postoperative infection and local skin necrosis. Patient acceptance is low.

[0006] Physical therapy: including laser, radio frequency, microwave, etc., which destroy sweat gland tissue through thermal effect and have the advantage of less trauma, but the efficacy depends on equipment parameters and operation techniques. Some patients need multiple treatments, the cost is high, and there are side effects such as short-term pigmentation and skin burns.

[0007] Injection therapy: such as local injection of botulinum toxin, which reduces sweat gland secretion by blocking neurotransmitters. It has a fast onset but a short duration (about 4-6 months) and requires repeated injections. Long-term use may lead to local muscle atrophy or drug resistance.

[0008] In recent years, the integration of traditional Chinese and Western medicine in the treatment of axillary odor has gradually gained attention. Traditional Chinese medicine believes that the occurrence of axillary odor is related to internal damp heat and poor blood circulation. Treatment methods are to clear away heat and dampness, astringe and stop sweating, and inhibit bacteria and deodorize. Traditional Chinese medicine ingredients such as borneol, coptis root, and alum are commonly used. However, their traditional dosage forms (such as powders and tinctures) have problems such as low solubility, poor transdermal absorption, and insufficient stability. In addition, the antibacterial spectrum of a single traditional Chinese medicine ingredient is relatively narrow, making it difficult to quickly curb the reproduction of pathogenic bacteria. Although Western medicine ingredients such as ketoconazole and ethanol have clear bactericidal and antibacterial effects, long-term single use can easily lead to microbial resistance, and high-concentration disinfectants may damage the skin barrier and aggravate local skin sensitivity.

[0009] Based on the above situation, there is an urgent need to develop a treatment preparation for axillary odor that combines the advantages of Chinese and Western medicine, has a novel dosage form, a long-lasting effect, and is mild and safe, so as to solve the problems existing in the existing technology such as incomplete antibacterial inhibition, poor dosage form comfort, and insufficient skin adaptability. Summary of the Invention

[0010] To address this issue and overcome the shortcomings of existing axillary odor treatment preparations, such as incomplete antibacterial activity, poor dosage form comfort, and insufficient skin compatibility, the present invention provides a long-lasting, mild, and safe aqueous emulsion combining the strengths of both traditional Chinese and Western medicines for the treatment of axillary odor, along with a method for its preparation. This formulation, through its unique water-oil emulsion system and compound ingredient design, combines multiple benefits, including high-efficiency antibacterial activity, astringency, antiperspirant properties, and skin care, significantly enhancing user comfort and therapeutic efficacy.

[0011] In order to achieve the above-mentioned purpose, the following technical scheme is adopted: On the one hand, the present invention provides a Chinese and Western medicine compound aqueous emulsion for treating axillary odor, which is composed of the following components in parts by weight: 50-200 parts of butter, 600-800 parts of disinfectant, 80-200 parts of emulsifier, 50-150 parts of fungicide, 10-40 parts of Chinese medicine powder and 100-300 parts of blood charcoal.

[0012] Blood charcoal is a carbonized product formed by calcining human hair under high-temperature, oxygen-deficient conditions. It also retains some of the biological activity of its organic components. During this process, the hair's keratin is decomposed and converted into carbon and small amounts of nitrogen-containing compounds such as peptides and amino acids. The rich microporous structure formed after calcination gives blood charcoal a strong adsorption capacity, effectively absorbing sweat, oil, and metabolites from the skin's surface, reducing the accumulation of odor precursors. It also reduces substrates for microbial decomposition, adsorbs pathogenic bacteria on the skin's surface, reduces microbial density, and curbs odor generation at the source. Incompletely carbonized amino acids, peptides, and other components retain biocompatibility, promoting the penetration of active ingredients in traditional Chinese medicine powders into hair follicles and sweat gland ducts, making it particularly suitable for drug delivery to areas with dense hair follicles under the arms. Furthermore, blood charcoal, derived from a processed product of human keratin, has a strong affinity for skin and is less likely to induce rejection, making it suitable for long-term use in sensitive areas.

[0013] The butter is added with the following nutritional ingredients: 90-110 mg of chamomile extract per 100 mL, 10-20 mg of knotweed root extract per 100 mL, 20-26 mg of wheat seed extract per 100 mL, and 20-30 mg of sunflower seed cake per 100 mL.

[0014] The butter has the following effects:

[0015] Butter generally has the function of moisturizing the skin and maintaining the water-oil balance of the skin. After using butter, it can not only keep the skin moisturized for a long time, but also maintain the water-oil balance of the skin, thereby effectively preventing the loss of skin moisture and avoiding allergic symptoms;

[0016] Butter also has the effects of improving skin and delaying aging. Butter can generally penetrate into the skin muscle layer, build a protective barrier for the skin, and can also improve skin blood circulation and promote cell metabolism in the body, thereby improving skin and delaying aging.

[0017] Butter can also relieve dryness and flaking, fragile skin, sensitive acne, redness and itching, and damaged skin sebum film.

[0018] Chamomile is a plant of the Asteraceae family. Chamomile extract is extracted from chamomile and contains a variety of active ingredients, such as flavonoids, terpenoids, etc. Flavonoids have antioxidant and anti-inflammatory properties. It can soothe sensitive skin mainly because it can inhibit the release of histamine, which is a medium that causes skin allergic reactions. At the same time, these ingredients can keep the stratum corneum on the surface of the skin properly hydrated, making the skin soft and smooth. Chamomile extract is suitable for sensitive skin. For example, when the skin develops redness, itching and other sensitive symptoms after changing seasons or using new skin care products, butter containing chamomile extract can help relieve these discomforts and keep the skin feeling good.

[0019] Polygonum cuspidatum is a plant of the Polygonaceae family, and Polygonum cuspidatum root extract is extracted from the root of Polygonum cuspidatum. Polygonum cuspidatum root contains ingredients such as emodin and resveratrol. Among them, resveratrol is a strong antioxidant that can scavenge free radicals and reduce the formation of melanin, thereby brightening dull skin tone. At the same time, these ingredients can also promote the metabolism of skin cells, increase skin elasticity and radiance, and make the skin softer and smoother. It has a good effect on improving uneven skin tone and dull skin. For example, if the skin is dull due to staying up late for a long time or exposure to ultraviolet rays, using butter containing Polygonum cuspidatum root extract can help brighten the skin tone and restore the skin's radiance.

[0020] Wheat seed extract comes from wheat seeds and is rich in vitamins (such as vitamin E), minerals, amino acids, and other nutrients. Vitamin E is a natural antioxidant that protects skin cells from free radical damage. The amino acids and other ingredients in it provide nutrients to skin cells, penetrating deep into the skin to help strengthen the skin's barrier function, stabilize the skin, and reduce external irritation. Using butter containing wheat seed extract can help repair and strengthen the skin barrier, making the skin more stable.

[0021] Sunflower seed cake, the remaining portion of sunflower seeds after oil extraction and other processing, is used to extract active ingredients. Sunflower seed cake is rich in oils, vitamins, and other ingredients. The oils provide moisture to the skin, forming a protective film on the surface to prevent moisture loss. Vitamins and other nutrients nourish the skin and soothe skin discomfort, such as those caused by dryness or minor inflammation. When skin feels dry and slightly irritated, butter containing sunflower seed cake extract can moisturize and nourish the skin, restoring it to a comfortable state.

[0022] Adding the above-mentioned plant extracts to the butter allows the product to be absorbed quickly. It has a moisturizing lotion texture that is easy to spread and absorb. The skin feels moisturized but not sticky, and clear but not thick.

[0023] The disinfectant is a disinfectant gel with ethanol and n-propanol as main active ingredients. The volume fraction of ethanol in the disinfectant is 54%-66%, and the volume fraction of n-propanol in the disinfectant is 9%-11%.

[0024] Ethanol destroys the lipid structure of microbial cell membranes, denaturing proteins and rendering them ineffective, thereby killing bacteria, viruses, and other pathogens. When mixed with ethanol, n-propanol can enhance its effectiveness against drug-resistant bacteria. n-propanol is also less volatile than ethanol, slowing the evaporation of the alcohol in the gel and prolonging its effective duration. It also improves the gel's viscosity and application, enhancing the user experience. Furthermore, ethanol and n-propanol are non-irritating and skin-friendly.

[0025] The emulsifier comprises the following components in weight percentage: 0.19%-0.23% of trifluorohydroxy diphenyl ether, 0.5%-3% of trichlorohydroxy diphenyl ether, 7%-9% of surfactant, 0.1%-0.5% of allantoin, 0.8%-1.5% of olive oil ester, 3%-8% of ethanol, and the balance is water.

[0026] Trifluorohydroxydiphenyl ether is a highly effective, broad-spectrum antimicrobial ingredient with strong antimicrobial activity, inhibiting the growth of a wide range of Gram-positive and Gram-negative bacteria, as well as fungi. Its mechanism of action is to disrupt the cell membrane structure of microorganisms and interfere with cellular metabolism, thereby exerting its antimicrobial effect. Adding a small amount of this ingredient to an emulsifier can help enhance the overall antimicrobial potency of the formulation. It is also mild and non-irritating, making it suitable for use in the sensitive underarm area.

[0027] Triclosan (also known as triclosan) is a commonly used broad-spectrum antimicrobial agent with significant inhibitory effects on skin-borne pathogens associated with axillary odor, such as Staphylococcus aureus and Corynebacterium. It inhibits fatty acid synthesis and disrupts microbial energy metabolism, thereby killing or inhibiting bacterial growth. This ingredient is highly stable and compatible with other components. In emulsifiers, it synergizes with disinfectants and traditional Chinese medicine powders to form a multi-layered antibacterial barrier.

[0028] The surfactant is a commonly used surfactant used in medicine. Surfactants are one of the core components of emulsifiers. Their main function is to reduce the interfacial tension between the water and oil phases, allowing the butter (oil phase) and the disinfectant (water phase) to mix evenly to form a stable aqueous emulsion system. Its molecular structure is both hydrophilic and lipophilic, which can help the active ingredients to be evenly dispersed, improving the coating and absorbability of the preparation. At the same time, mild surfactants can clean dirt and excess oil on the skin surface, creating a clean environment for drug penetration without excessively damaging the skin barrier, ensuring comfort during use.

[0029] Allantoin, a natural ingredient extracted or synthesized from plants in the Boraginaceae family, possesses remarkable skin-repairing and soothing properties. It promotes the proliferation and differentiation of epidermal cells, accelerating the healing of damaged skin while also alleviating discomfort such as redness, swelling, and itching caused by external stimuli. Adding allantoin to emulsifiers enhances the protective properties of the formulation for sensitive underarm skin, reducing potential irritation from disinfectants or traditional Chinese medicine ingredients. This makes it particularly suitable for maintaining healthy skin during long-term use.

[0030] Olive oil esters are natural fatty acid esters extracted from olive oil. Rich in vitamin E and unsaturated fatty acids, they offer excellent moisturizing and hydrating properties. They form a thin protective film on the skin's surface, locking in moisture and strengthening the skin's barrier function, preventing water loss while improving the formulation's skin-friendliness and spreadability. This ingredient is mild and easily absorbed by the skin, improving the feel of water-based emulsions and leaving them feeling fresh and non-sticky upon application. It is suitable for underarms, a particular area prone to perspiration and friction.

[0031] Ethanol plays a dual role as a solvent and auxiliary antibacterial agent in emulsifiers. It can help dissolve fat-soluble components such as trifluorohydroxydiphenyl ether and trichlorohydroxydiphenyl ether, and promote uniform mixing of various components. At the same time, as an antibacterial component, a certain concentration of ethanol can quickly destroy bacterial cell membranes and inhibit microbial growth.

[0032] The emulsifier adopts a neutral formula, is mild in nature, produces fine foam, can fully cleanse the skin, and has a bactericidal effect on intestinal pathogens and pyogenic cocci.

[0033] The fungicide is ketoconazole cream with an active ingredient mass fraction of 1-5%.

[0034] The traditional Chinese medicine powder is composed of the following components in parts by weight: 1-3 parts of borneol, 2-8 parts of coptis root powder, 2-8 parts of alum, 1-3 parts of boric acid and 2-8 parts of calomel.

[0035] Borneol is a processed resin from the Dipterocarpaceae plant borneol, or a crystal synthesized from camphor, turpentine, and other ingredients. It is pungent, bitter, and slightly cold in nature, and enters the heart, spleen, and lung meridians. Its primary effects include cooling and antibacterial properties, refreshing the mind, and reducing swelling and alleviating pain. The borneol component contained in borneol is highly volatile and quickly penetrates the skin upon application, exerting an antibacterial effect and inhibiting the growth of microorganisms in the armpits. Its cooling effect can also relieve localized discomfort and reduce the sticky feeling after sweating. Combined with other traditional Chinese medicine ingredients, it enhances transdermal absorption, making it a commonly used lead drug in topical preparations in Traditional Chinese Medicine.

[0036] Coptis chinensis powder is derived from the dried rhizome of the Ranunculaceae plant Coptis chinensis. It is cold in nature, bitter in taste, and enters the heart, liver, stomach, and large intestine meridians. It is rich in alkaloids such as berberine (berberine). According to Traditional Chinese Medicine (TCM), Coptis chinensis has the effects of clearing heat and dampness, purging fire and detoxifying, and can eliminate dampness and heat in the body, improving the pathological condition of internal dampness and heat in the axillae. Modern pharmacological research has shown that berberine has a broad-spectrum inhibitory effect against Gram-positive bacteria such as Staphylococcus and Streptococcus, as well as various fungi. It can directly kill the pathogenic bacteria associated with underarm odor, thus reducing the production of odor-causing substances. It is the core heat-clearing and antibacterial component of the compound.

[0037] Alum is a crystallized product derived from the sulfate mineral alunite, processed and refined. Its main component is potassium aluminum sulfate dodecahydrate. It is acidic, astringent, and cold in nature, and enters the lung, spleen, liver, and large intestine meridians. Its primary benefits are astringency, drying dampness, and antiperspirant and antipruritic properties, making it commonly used to treat conditions such as hyperhidrosis and eczema. Alum dissolves in water to form a colloidal precipitate that absorbs excess sweat and secretions from the skin, reducing the substrate for bacterial growth. Its astringent properties also temporarily constrict pores, inhibiting sweat secretion and reducing odor at the source. It is a commonly used antiperspirant and astringent ingredient in traditional topical preparations.

[0038] Boric acid, an oxygen-containing acid of boron, is cooling and sour in nature, possessing astringent, antibacterial, and antiseptic properties. In topical dermatological preparations, boric acid is commonly used to treat conditions associated with exudation, such as eczema and dermatitis. Its weakly acidic environment inhibits bacterial growth, while its mild astringency reduces local sweat secretion and alleviates dampness. In traditional Chinese medicine powders, boric acid synergizes with alum to enhance its astringent and antiperspirant effects, while also regulating the local pH to create an environment unfavorable for microbial growth, complementing the antibacterial effects of ingredients such as coptis root and borneol.

[0039] Calomel is a crystal of mercurous chloride produced by the sublimation of mercury, alum, and salt. It is pungent, cold, and toxic, and enters the large and small intestine meridians. It has insecticidal, antibacterial, and sore-healing properties. Ancient Chinese medical texts record that calomel can treat scabies, ulcers, and skin ulcers. The mercury compounds it contains have a strong inhibitory effect on various fungi and bacteria, rapidly killing pathogenic microorganisms in the armpits and blocking the decomposition of odor-causing substances.

[0040] On the other hand, the present invention also provides a method for preparing a compound aqueous emulsion of Chinese and Western medicines for treating underarm odor, comprising the following steps:

[0041] (1) Weigh borneol, coptis root powder, alum, boric acid, and calomel by weight, put them into a grinder, grind them into uniform particle diameters, and sieve them through a 150-mesh sieve to ensure that the powder is fine and free of lumps, thereby obtaining a Chinese medicine powder for later use;

[0042] (2) placing butter in a reaction vessel, heating it to 40-50° C. to melt it into a liquid state, adding nutrients in proportion: chamomile extract, knotweed root extract, wheat seed extract, and sunflower seed cake powder, stirring at a speed of 100-150 rpm for 10-15 minutes to fully blend the nutrients with the butter, and cooling it to room temperature for later use;

[0043] (3) Weighing the emulsifier components by weight, mixing them, and stirring at 200-300 rpm for 20-30 minutes to form a uniform and transparent emulsifier solution;

[0044] (4) Add butter and disinfectant to the main reactor, stir at room temperature at 100-200 rpm for 10-30 min, then slowly add emulsifier, continue stirring for 5-10 min to form a stable water-oil mixed system, then add fungicide, stir for 5-15 min, finally add blood charcoal and sieved Chinese medicine powder, stir at high speed at 300-500 rpm for 20-40 min to ensure that the powder is evenly distributed in the system, after stirring, let it stand for 1 hour to observe the stability of the system, and if there is no stratification or precipitation, the finished product of Chinese and Western medicine compound water emulsion is obtained.

[0045] The beneficial effects of the present invention are:

[0046] (1) The present invention is a water emulsion dosage form. Compared with traditional water preparations, the stable film layer formed by its active ingredients on the skin surface can prolong the duration of action and reduce the inconvenience of frequent medication. Compared with emulsions or lipids, its texture is clear and delicate, and its moisturizing lotion is easy to spread and absorb. It feels moist and not sticky on the skin, maintaining skin affinity and comfort while avoiding a greasy and heavy feeling, making it suitable for long-term daily use.

[0047] (2) The present invention uses butter as the core matrix, supplemented by plant extracts such as chamomile, knotweed root, wheat seed and sunflower seed cake, to construct a multiple skin care system. The butter itself can moisturize the skin, maintain the water-oil balance, and form a protective barrier on the skin surface to prevent water loss and resist external stimuli; the anti-inflammatory and antioxidant properties of chamomile extract can relieve discomfort such as sensitivity, redness, and itching; the knotweed root extract brightens the skin tone and promotes metabolism; the wheat seed extract strengthens the skin barrier function; and the sunflower seed cake component moisturizes and soothes dry skin. The synergistic effect of multiple ingredients not only improves skin comfort, but also creates good conditions for drug penetration and enhances the transdermal absorption efficiency of active ingredients.

[0048] (3) The blood residue carbon component in the present invention not only reduces odor precursors by physical adsorption, but also enhances drug penetration due to the presence of active proteins in the chemical component, and is non-irritating to the skin, thereby significantly enhancing the overall therapeutic effect and safety of the compound aqueous emulsion.

[0049] (4) The present invention can specifically inhibit the reproduction of fungi, and its overall bactericidal and disinfecting ability reaches the level of surgical disinfection. It can quickly curb the growth of pathogenic microorganisms related to axillary odor and reduce the generation of odor from the source.

[0050] (5) Chinese medicine powders are made of medicinal materials such as borneol, coptis root powder, alum, boric acid, and calomel, which can exert the effects of antibacterial, astringent, clearing heat and drying dampness in traditional Chinese medicine: borneol is cooling and antibacterial, coptis root powder clears heat and purges fire, alum and boric acid are astringent and drying dampness, and calomel is insecticidal and antibacterial. Multiple ingredients synergistically regulate the local flora environment of the armpit, inhibit the excessive proliferation of abnormal microorganisms, and establish a benign flora balance. This compound complements the bactericidal ingredients of Western medicine to achieve the goal of rapid antibacterial and deodorization, avoid the problem of drug resistance of a single ingredient, and is easy to use, with both long-lasting effect and safety, meeting clinical and daily care needs. DETAILED DESCRIPTION

[0051] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0052] Unless otherwise defined, all technical and scientific terms used herein have the same meanings as those familiar to those skilled in the art. Furthermore, any methods and materials similar or equivalent to those described herein can be applied to the present invention. The preferred embodiments and materials described herein are for illustrative purposes only and are not intended to limit the scope of this application.

[0053] The experimental methods in the following examples, unless otherwise specified, are all conventional methods, and the experimental materials used in the following examples, unless otherwise specified, are all purchased from commercial channels.

[0054] Example 1

[0055] A Chinese and Western medicine compound aqueous emulsion for treating underarm odor and its preparation method

[0056] The Chinese and western medicine compound aqueous emulsion is composed of the following components in parts by weight: 50 parts of butter, 600 parts of disinfectant, 80 parts of emulsifier, 50 parts of fungicide, 10 parts of Chinese medicine powder and 100 parts of blood charcoal.

[0057] The butter is added with the following nutritional ingredients: 90 mg of chamomile extract per 100 mL, 10 mg of knotweed root extract per 100 mL, 20 mg of wheat seed extract per 100 mL, and 20 mg of sunflower seed cake per 100 mL.

[0058] The disinfectant is a disinfectant gel with ethanol and n-propanol as main active ingredients. The volume fraction of ethanol in the disinfectant is 54%, and the volume fraction of n-propanol in the disinfectant is 9%.

[0059] The emulsifier comprises the following components in percentage by weight: 0.19% trifluorohydroxy diphenyl ether, 0.5% trichlorohydroxy diphenyl ether, 7% surfactant, 0.1% allantoin, 0.8% olive oil ester, 3% ethanol, and the balance is water.

[0060] The fungicide is ketoconazole cream with an active ingredient mass fraction of 1%.

[0061] The traditional Chinese medicine powder is composed of the following components in parts by weight: 1 part of borneol, 2 parts of coptis root powder, 2 parts of alum, 1 part of boric acid and 2 parts of calomel.

[0062] The preparation method of the Chinese and Western medicine compound aqueous emulsion for treating underarm odor comprises the following steps:

[0063] (1) Weigh borneol, coptis root powder, alum, boric acid, and calomel by weight, put them into a grinder, grind them into uniform particle diameters, and sieve them through a 150-mesh sieve to ensure that the powder is fine and free of lumps, thereby obtaining a Chinese medicine powder for later use;

[0064] (2) Place butter in a reaction vessel, heat to 40°C to melt it into a liquid state, add nutrients in proportion: chamomile extract, knotweed root extract, wheat seed extract, and sunflower seed cake powder, stir at 100 rpm for 10 minutes to fully blend the nutrients and butter, and cool to room temperature for use;

[0065] (3) Weighing the emulsifier components by weight, mixing them, and stirring at 200 rpm for 20 min to form a uniform and transparent emulsifier solution;

[0066] (4) Add butter and disinfectant to the main reactor, stir at room temperature at 100 rpm for 10 minutes, then slowly add emulsifier and continue stirring for 5 minutes to form a stable water-oil mixed system, then add fungicide and stir for 5 minutes, finally add blood charcoal and sieved Chinese medicine powder, stir at high speed at 300 rpm for 20 minutes to ensure that the powder is evenly distributed in the system, after stirring, let it stand for 1 hour to observe the stability of the system, and if there is no stratification or precipitation, the finished product of Chinese and Western medicine compound water emulsion is obtained.

[0067] Example 2

[0068] A Chinese and Western medicine compound aqueous emulsion for treating underarm odor and its preparation method

[0069] The Chinese and western medicine compound aqueous emulsion is composed of the following components in parts by weight: 200 parts of butter, 800 parts of disinfectant, 200 parts of emulsifier, 150 parts of fungicide, 40 parts of Chinese medicine powder and 300 parts of blood charcoal.

[0070] The butter is added with the following nutritional ingredients: 110 mg of chamomile extract per 100 mL, 20 mg of knotweed root extract per 100 mL, 26 mg of wheat seed extract per 100 mL, and 30 mg of sunflower seed cake per 100 mL.

[0071] The disinfectant is a disinfectant gel with ethanol and n-propanol as main active ingredients. The volume fraction of ethanol in the disinfectant is 66%, and the volume fraction of n-propanol in the disinfectant is 11%.

[0072] The emulsifier comprises the following components in percentage by weight: 0.23% trifluorohydroxy diphenyl ether, 3% trichlorohydroxy diphenyl ether, 9% surfactant, 0.5% allantoin, 1.5% olive oil ester, 8% ethanol, and the balance is water.

[0073] The fungicide is ketoconazole cream with an active ingredient mass fraction of 5%.

[0074] The traditional Chinese medicine powder is composed of the following components in parts by weight: 3 parts of borneol, 8 parts of coptis root powder, 8 parts of alum, 3 parts of boric acid and 8 parts of calomel.

[0075] The preparation method of the Chinese and Western medicine compound aqueous emulsion for treating underarm odor comprises the following steps:

[0076] (1) Weigh borneol, coptis root powder, alum, boric acid, and calomel by weight, put them into a grinder, grind them into uniform particle diameters, and sieve them through a 150-mesh sieve to ensure that the powder is fine and free of lumps, thereby obtaining a Chinese medicine powder for later use;

[0077] (2) Place butter in a reaction vessel, heat to 50°C to melt it into a liquid state, add nutrients in proportion: chamomile extract, knotweed root extract, wheat seed extract, and sunflower seed cake powder, stir at 150 rpm for 15 minutes to fully blend the nutrients and butter, and cool to room temperature for use;

[0078] (3) Weighing the emulsifier components by weight, mixing them, and stirring at 300 rpm for 30 min to form a uniform and transparent emulsifier solution;

[0079] (4) Add butter and disinfectant to the main reactor, stir at room temperature at 200 rpm for 30 minutes, then slowly add emulsifier and continue stirring for 10 minutes to form a stable water-oil mixed system, then add fungicide and stir for 15 minutes, finally add blood charcoal and sieved Chinese medicine powder, stir at high speed at 500 rpm for 40 minutes to ensure that the powder is evenly distributed in the system, after stirring, let it stand for 1 hour to observe the stability of the system, and if there is no stratification or precipitation, the finished product of Chinese and Western medicine compound water emulsion is obtained.

[0080] Example 3

[0081] A Chinese and Western medicine compound aqueous emulsion for treating underarm odor and its preparation method

[0082] The Chinese and western medicine compound aqueous emulsion is composed of the following components in parts by weight: 100 parts of butter, 700 parts of disinfectant, 100 parts of emulsifier, 80 parts of fungicide, 20 parts of Chinese medicine powder and 200 parts of blood charcoal.

[0083] The butter is added with the following nutritional ingredients: 100 mg of chamomile extract per 100 mL, 15 mg of knotweed root extract per 100 mL, 23 mg of wheat seed extract per 100 mL, and 25 mg of sunflower seed cake per 100 mL.

[0084] The disinfectant is a disinfectant gel with ethanol and n-propanol as main active ingredients. The volume fraction of ethanol in the disinfectant is 60%, and the volume fraction of n-propanol in the disinfectant is 10%.

[0085] The emulsifier comprises the following components in percentage by weight: 0.21% trifluorohydroxy diphenyl ether, 1.75% trichlorohydroxy diphenyl ether, 8% surfactant, 0.3% allantoin, 1.15% olive oil ester, 5.5% ethanol, and the balance is water.

[0086] The fungicide is ketoconazole cream with an active ingredient mass fraction of 3%.

[0087] The traditional Chinese medicine powder is composed of the following components in parts by weight: 2 parts of borneol, 5 parts of coptis root powder, 5 parts of alum, 2 parts of boric acid and 5 parts of calomel.

[0088] The preparation method of the Chinese and Western medicine compound aqueous emulsion for treating underarm odor comprises the following steps:

[0089] (1) Weigh borneol, coptis root powder, alum, boric acid, and calomel by weight, put them into a grinder, grind them into uniform particle diameters, and sieve them through a 150-mesh sieve to ensure that the powder is fine and free of lumps, thereby obtaining a Chinese medicine powder for later use;

[0090] (2) Place butter in a reaction vessel, heat to 45°C to melt it into a liquid state, add nutrients in proportion: chamomile extract, knotweed root extract, wheat seed extract, and sunflower seed cake powder, stir at 120 rpm for 12 minutes to fully blend the nutrients and butter, and cool to room temperature for use;

[0091] (3) Weighing the emulsifier components by weight, mixing them, and stirring at 250 rpm for 25 minutes to form a uniform and transparent emulsifier solution;

[0092] (4) Add butter and disinfectant to the main reactor, stir at room temperature at 150 rpm for 20 min, then slowly add emulsifier and continue stirring for 8 min to form a stable water-oil mixture system, then add fungicide and stir for 10 min, finally add blood charcoal and sieved Chinese medicine powder, stir at high speed at 400 rpm for 30 min to ensure that the powder is evenly distributed in the system, after stirring, let it stand for 1 h to observe the stability of the system, and if there is no stratification or precipitation, the finished product of Chinese and Western medicine compound water emulsion is obtained.

[0093] Example 4

[0094] A Chinese and Western medicine compound aqueous emulsion for treating underarm odor and its preparation method

[0095] The Chinese and Western medicine compound aqueous emulsion is composed of the following components in parts by weight: 200 parts of butter, 800 parts of disinfectant, 100 parts of emulsifier, 50 parts of fungicide, 20 parts of Chinese medicine powder and 100 parts of blood charcoal, and the rest are the same as in Example 3.

[0096] Example 5

[0097] A Chinese and Western medicine compound aqueous emulsion for treating underarm odor and its preparation method

[0098] The Chinese and Western medicine compound aqueous emulsion is composed of the following components in parts by weight: 50 parts of butter, 800 parts of disinfectant, 200 parts of emulsifier, 100 parts of fungicide, 40 parts of Chinese medicine powder and 200 parts of blood charcoal, and the rest are the same as in Example 3.

[0099] Test Example 1

[0100] Antibacterial test of aqueous emulsions of Chinese and Western medicines

[0101] The Oxford agar diffusion method was used to determine the diameter of the inhibition zone of the compound aqueous emulsion against Staphylococcus aureus (a Gram-positive bacterium) and Corynebacterium spp. (the primary pathogenic bacteria causing axillary odor). The broth microdilution method was used to determine the minimum inhibitory concentration (MIC) of the compound aqueous emulsion against Candida albicans (a fungus). The results of these tests are shown in Table 1. A larger inhibition zone diameter indicates a stronger inhibitory effect against bacteria; a smaller MIC value indicates a lower minimum inhibitory concentration against fungi and a more significant antibacterial effect.

[0102] As can be seen from Table 1, the aqueous emulsion of Chinese and Western medicine disclosed in this aspect has a large inhibition zone diameter against Staphylococcus aureus and Corynebacterium (the main pathogens of axillary odor), and a low MIC against Candida albicans, indicating that it has a broad antibacterial spectrum and significant effect. This aqueous emulsion can cover a variety of pathogens such as Gram-positive bacteria and fungi, curb the production of odorous substances, and solve the problems of narrow antibacterial spectrum and drug resistance of single ingredients. Among them, Example 3 performed the best.

[0103] Table 1 Antibacterial test results of Chinese and Western medicine compound aqueous emulsions

[0104]

[0105] Test Example 2

[0106] Skin compatibility test of Chinese and Western medicine compound aqueous emulsion

[0107] Each group consisted of 20 subjects, aged 18-50 years, randomly assigned to Groups 1-5 of Examples 1-5, with a male-to-female ratio of 1:1. Subjects were diagnosed with axillary odor (meeting the clinical diagnostic criteria for axillary odor: a pungent odor emanating from the armpits, aggravated by heat, exercise, or emotional stress). Subjects with axillary skin damage, inflammation, or surgery or laser treatment within the past month were excluded; subjects with known allergies to ethanol, ketoconazole, or traditional Chinese medicine ingredients (such as borneol and coptis root) were excluded; and women who were pregnant or breastfeeding were excluded.

[0108] Observation time point:

[0109] Immediate reaction (0.5h): Observe the skin 30 minutes after application for acute irritation reactions such as erythema, edema, papules, itching, etc.

[0110] Short-term reactions (24 hours): Observe your skin at the same time the next day and record any symptoms such as persistent redness and burning sensation.

[0111] Long-term reaction (7 days): After 7 days of continuous use, evaluate the skin barrier function (such as dryness, desquamation, clogged pores, etc.).

[0112] Scoring is based on the following criteria:

[0113] 5 points: No irritation (no erythema, edema, or itching), skin feels refreshed, absorbed within 5 minutes after application, and no sticky residue;

[0114] 4 points: Slight transient redness (dissipates within 30 minutes), no edema or itching, good skin feel, slightly moisturized but not sticky;

[0115] 3 points: moderate erythema, accompanied by mild itching (tolerable, no drug intervention required), slightly sticky skin feeling but not affecting daily life.

[0116] 2 points: Obvious erythema / edema, significant itching requiring drug discontinuation, or signs of skin barrier damage such as dryness and scaling, and clogged pores.

[0117] 1 point: Severe allergic reaction (blisters, peeling, exudate), or contact dermatitis requiring medical intervention.

[0118] The above test results are shown in Table 2.

[0119] Table 2 Skin compatibility test results of Chinese and Western medicine compound aqueous emulsions

[0120] Fraction Example 1 Example 2 Example 3 Example 4 Example 5 5 points 10 9 16 12 10 4 points 9 9 3 6 8 3 points 1 2 1 2 2 2 points 0 0 0 0 0 1 point 0 0 0 0 0

[0121] As can be seen from Table 2, among all groups of subjects, the proportion of scores of 4-5 (no irritation / mild comfort reaction) was ≥90%, and no severe irritation or allergic reaction (such as erythema, edema, blister exudation, damaged skin barrier, etc.) with a score of 2 or less occurred. This shows that the formula of the present invention is particularly outstanding in terms of skin feel and low irritation. Within 30 minutes after application, 90% of the subjects did not have any acute irritation reaction, and 80% reported that the skin felt refreshed, and the product was completely absorbed within 5 minutes, with no sticky residue. This fully meets the design goal of the invention's formulation of a clear, easily absorbed, and moisturizing non-sticky formulation. Butter can form a non-occlusive protective film on the skin surface, locking in moisture while maintaining pore permeability, avoiding the risk of folliculitis caused by traditional ointments due to greasy pore clogging. In addition, components such as plant extracts and blood charcoal are all pure natural ingredients and are non-irritating to the skin.

[0122] Test Example 3

[0123] Efficacy test of Chinese and Western medicine compound aqueous emulsion in treating axillary odor

[0124] Perform the test according to the standards of Test Example 2 and score according to the following standards after 7 days of testing:

[0125] 5 points: The odor completely disappears, the secretion of axillary sweat is significantly reduced, and there is no odor under the armpit after sweating;

[0126] 4 points: The odor is significantly reduced, the secretion of axillary sweat is significantly reduced, and there is a small amount of odor in the armpit after sweating;

[0127] 3 points: The odor is partially reduced, the secretion of axillary sweat is slightly reduced, and there is more odor in the armpit after sweating;

[0128] 2 points: Slight improvement in odor, no significant reduction in axillary sweat secretion, and a large amount of odor in the armpits after sweating;

[0129] 1 point: No improvement or worsening, with no significant improvement in axillary sweat secretion and post-sweating odor.

[0130] The above test results are shown in Table 3.

[0131] Table 3 Test results of the efficacy of Chinese and Western medicine compound aqueous emulsion in treating axillary odor

[0132] Fraction Example 1 Example 2 Example 3 Example 4 Example 5 5 points 8 9 17 13 8 4 points 8 9 3 5 7 3 points 4 3 0 2 5 2 points 0 0 0 0 0 1 point 0 0 0 0 0

[0133] As can be seen from the data in Table 3, after 7 days of use, the odor of more than 80% of the subjects was reduced or disappeared (4-5 points), and the secretion of axillary sweat decreased. This shows that the aqueous emulsion has antibacterial and deodorizing effects, reduces sweat secretion, and forms a long-lasting film layer through the water-oil emulsion system, which prolongs the action time of the active ingredients and has significant therapeutic effects on axillary odor.

[0134] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to these embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the appended claims and their equivalents.

[0135] The above description of the present invention and its embodiments is non-limiting and its practical applications are not limited thereto. In short, if a person skilled in the art is inspired by the above description and designs similar methods and embodiments to the technical solution without departing from the purpose of the present invention, they shall fall within the scope of protection of the present invention.

Claims

1. A Chinese and Western medicine compound aqueous emulsion for treating underarm odor, characterized by: The invention is composed of the following components in parts by weight: 50-200 parts of butter, 600-800 parts of disinfectant, 80-200 parts of emulsifier, 50-150 parts of fungicide, 10-40 parts of traditional Chinese medicine powder and 100-300 parts of blood charcoal.

2. The Chinese and Western medicine compound aqueous emulsion for treating underarm odor according to claim 1, characterized in that: The butter is added with the following nutritional ingredients: 90-110 mg of chamomile extract per 100 mL, 10-20 mg of knotweed root extract per 100 mL, 20-26 mg of wheat seed extract per 100 mL, and 20-30 mg of sunflower seed cake per 100 mL.

3. The Chinese and Western medicine compound aqueous emulsion for treating underarm odor according to claim 2, characterized in that: The disinfectant is a disinfectant gel with ethanol and n-propanol as main active ingredients. The volume fraction of ethanol in the disinfectant is 54%-66%, and the volume fraction of n-propanol in the disinfectant is 9%-11%.

4. The Chinese and Western medicine compound aqueous emulsion for treating underarm odor according to claim 3, characterized in that: The emulsifier comprises the following components in weight percentage: 0.19%-0.23% of trifluorohydroxy diphenyl ether, 0.5%-3% of trichlorohydroxy diphenyl ether, 7%-9% of surfactant, 0.1%-0.5% of allantoin, 0.8%-1.5% of olive oil ester, 3%-8% of ethanol, and the balance is water.

5. The Chinese and Western medicine compound aqueous emulsion for treating underarm odor according to claim 4, characterized in that: The fungicide is ketoconazole cream with an active ingredient mass fraction of 1-5%.

6. The Chinese and Western medicine compound aqueous emulsion for treating underarm odor according to claim 5, characterized in that: The traditional Chinese medicine powder is composed of the following components in parts by weight: 1-3 parts of borneol, 2-8 parts of coptis root powder, 2-8 parts of alum, 1-3 parts of boric acid and 2-8 parts of calomel.

7. A method for preparing the Chinese and Western medicine compound aqueous emulsion for treating underarm odor according to any one of claims 1 to 6, characterized in that: The following steps are involved: (1) Weigh borneol, coptis root powder, alum, boric acid, and calomel by weight, put them into a grinder, grind them into uniform particle diameters, and sieve them through a 150-mesh sieve to ensure that the powder is fine and free of lumps, thereby obtaining a Chinese medicine powder for later use; (2) placing butter in a reaction vessel, heating it to 40-50° C. to melt it into a liquid state, adding nutrients in proportion: chamomile extract, knotweed root extract, wheat seed extract, and sunflower seed cake powder, stirring at a speed of 100-150 rpm for 10-15 minutes to fully blend the nutrients with the butter, and cooling it to room temperature for later use; (3) Weighing the emulsifier components by weight, mixing them, and stirring at 200-300 rpm for 20-30 minutes to form a uniform and transparent emulsifier solution; (4) Add butter and disinfectant to the main reactor, stir at room temperature at 100-200 rpm for 10-30 min, then slowly add emulsifier, continue stirring for 5-10 min to form a stable water-oil mixed system, then add fungicide, stir for 5-15 min, finally add blood charcoal and sieved Chinese medicine powder, stir at high speed at 300-500 rpm for 20-40 min to ensure that the powder is evenly distributed in the system, after stirring, let it stand for 1 hour to observe the stability of the system, and if there is no stratification or precipitation, the finished product of Chinese and Western medicine compound water emulsion is obtained.

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