Liquid suspension for gastroesophageal mucosa repair and preparation method thereof

Abstract

The invention belongs to the technical field of medicines, and particularly relates to a liquid suspension for gastroesophageal mucosa repair and a preparation method thereof. The composition containing the gastroesophageal mucosa repairing active component comprises a traditional Chinese medicine active component for gastroesophageal mucosa repairing, at least one bioadhesive material and at least one material floating and retained in the stomach; the composition can be used for relieving stomachache, burning heat sensation, sour regurgitation and gastroesophageal reflux disease caused by hyperacidity, and can also be used for protecting and repairing digestive tract mucosa such as chronic gastritis, gastric ulcer and duodenal ulcer.

Description

[0001] This invention is a divisional application of the Chinese patent "Compositions, preparations and preparation methods for repairing gastroesophageal mucosa" with application number 2022117134120 and application date December 29, 2022. Technical Field

[0002] The present invention belongs to the field of medical technology, and in particular relates to a composition and preparation for repairing gastroesophageal mucosa and a preparation method thereof. Background Art

[0003] Gastroesophageal reflux disease (GERD) is a common digestive tract disorder. Lower esophageal sphincter dysfunction or other structural abnormalities associated with its function can lead to low lower esophageal sphincter pressure, which in turn causes reflux. Patients often experience heartburn, acid reflux, and pain and difficulty swallowing. In severe cases, reflux can irritate the pharyngeal mucosa, causing pharyngitis, hoarseness, aspiration pneumonia, and other symptoms.

[0004] GERD is a multifactorial disease caused by a variety of factors that disrupt digestive tract motility, including the presence of acidic or other harmful substances such as bile acid and pancreatic enzymes. Under normal circumstances, the esophagus itself has the ability to defend against invasion by gastric acid and duodenal contents, including an anti-reflux barrier, esophageal clearance, and esophageal mucosal tissue resistance. However, GERD is ultimately caused by a decrease in the anti-reflux barrier and defense mechanisms, coupled with damage to the esophageal mucosa caused by reflux.

[0005] Chronic gastritis, atrophic gastritis, and gastric cancer are common clinical digestive system diseases, all closely linked to varying degrees of damage to the gastric mucosal tissue. The WHO-recognized pattern of digestive system tumor progression is chronic gastritis—atrophic gastritis—intestinal metaplasia—dysplasia—gastric cancer. Epidemiological surveys show that the incidence of chronic gastritis in my country exceeds 60%, of which atrophic gastritis accounts for approximately 20%. Chronic gastritis with atrophic gastritis ultimately develops into gastric cancer in approximately 3% to 4%, a significant number. Therefore, actively protecting the gastric mucosa and repairing damage is of great clinical significance for the treatment of digestive system diseases and the prevention of further deterioration.

[0006] Peptic ulcers primarily refer to chronic ulcers that occur in the stomach and duodenum, also known as gastric and duodenal ulcers. They are named because their formation is linked to the digestive effects of gastric acid and pepsin. Peptic ulcers are a common clinical condition with a high incidence, affecting approximately 10% of the population. Duodenal ulcers are more common in young and middle-aged adults, with men more likely to develop them than women.

[0007] Although the etiology is not yet fully understood, the basic pathogenesis is the enhancement of mucosal invasive factors and / or the weakening of mucosal defense-repair factors.

[0008] It is currently believed that abnormal gastric acid secretion, dietary and environmental factors, Helicobacter pylori (Hp) infection, and damage to the digestive tract mucosa are related. When the balance between invasive and protective factors is lost, the related diseases and symptoms arise. Numerous drugs are marketed for the treatment of these indications, most of which are chemical drugs, primarily antacids, proton pump inhibitors, and H2 receptor blockers. However, chemical drugs have significant side effects and are not suitable for long-term use in the chronic stage, leading to recurrent attacks. Traditional Chinese medicine (TCM), as one of the important methods for preventing and treating digestive system diseases, has a solid foundation in clinical practice. Due to its multi-target, bidirectional regulatory effects, it has good efficacy, minimal toxicity and side effects, and a low recurrence rate. It is suitable for long-term administration of chronic diseases and is therefore widely accepted by patients. In recent years, an increasing number of studies have found that TCM can play a protective role in the gastric mucosa, providing an effective solution for exploring the clinical prevention and treatment of upper gastrointestinal diseases.

[0009] In recent years, a large number of studies have emerged on the relationship between traditional Chinese medicine and gastric mucosa. However, the preparation and processing of traditional Chinese medicine cannot meet clinical needs. For example, traditional tablets, granules, capsules, and ordinary oral liquids have not been optimized for the route of administration. There is no research on the protection and repair of the digestive tract mucosa for chronic gastritis, gastric ulcers, duodenal ulcers, etc. by long-term retention of these products in the stomach. Summary of the Invention

[0010] The present invention provides a composition and a preparation thereof containing gastroesophageal mucosa repairing active ingredients of a traditional Chinese medicine for gastroesophageal mucosa repair, which can be retained in the digestive tract such as the stomach for a long time to promote the protection and repair of the mucosa.

[0011] In order to achieve the above object, the present invention adopts the following technical solutions:

[0012] A composition for repairing gastroesophageal mucosa, comprising the following components in parts by mass:

[0013] Gastroesophageal mucosal repair active ingredients 0.1-20

[0014] Bioadhesive material 0.1-10

[0015] Suspended retention component 2-20;

[0016] The bioadhesive material is selected from acrylic acid polymers, cellulose derivatives, povidone, polyvinyl methyl ether-maleic anhydride copolymer, natural gums and polysaccharides;

[0017] The suspended retention component comprises part a and part b, wherein part a is selected from gums and polysaccharides of natural origin, vinyl pyrrolidone, copolymers of vinyl pyrrolidone and vinyl acetate, cellulose and its derivatives, acrylic acid polymers and their salts;

[0018] Part b is selected from ingredients that form effervescence with H+, or sodium carboxymethyl cellulose, cross-linked sodium carboxymethyl starch, cross-linked polyvinylpyrrolidone, cross-linked sodium carboxymethyl cellulose, and low-substituted hydroxypropyl cellulose.

[0019] For example, polymers such as acrylic acid polymers, vinyl pyrrolidone, and cellulose derivatives can be used as suspension retention components in the present invention due to their structural characteristics; they can also be used as bioadhesive materials.

[0020] Particularly, when the suspended component is insoluble in water / Class II / Class III solvents described by ICH, the particle size is ≤100 μm.

[0021] Particularly, the gastroesophageal mucosal repair active ingredient is selected from: American cockroach extract, jasmine extract, licorice extract, atractylodes extract, dendrobium extract, sea buckthorn extract, atractylodes extract, tangerine peel extract, bletilla striata extract, and yanhusuo extract.

[0022] In particular, pharmaceutically acceptable salts and excipients are also included.

[0023] In the present invention,

[0024] The preparation method of the aforementioned composition for repairing gastroesophageal mucosa comprises the following steps:

[0025] (1) placing a bioadhesive material in a solvent, stirring uniformly, and adjusting the pH value to obtain a mixture 1;

[0026] (2) adding a portion of the gastric floating retained components, pharmaceutically acceptable salts, and excipients to water and stirring uniformly to prepare a uniform mixture 2;

[0027] (3) Add mixture 2 to mixture 1, stir thoroughly, add the active ingredients of traditional Chinese medicine for gastroesophageal mucosal repair and the remaining ingredients, make up the water, stir evenly, and fill.

[0028] Particularly, in the step (1), the solvent is deionized water or a Class II / Class III solvent in ICH.

[0029] Particularly, the pH of the finished product is 5.0-9.5 (more preferably 7.0-9.5); the density is 0.9-1.2 g / ml; and the viscosity is ≤4000 mPa·s.

[0030] The present invention also protects the use of the aforementioned gastroesophageal mucosal repair composition in the preparation of medicines for relieving stomach pain, heartburn, and acid reflux caused by excessive gastric acid, improving gastroesophageal reflux disease, and repairing and protecting the digestive tract mucosa of chronic gastritis, gastric ulcer, duodenal ulcer, etc.

[0031] Compared with the prior art, the composition prepared by the present invention is a liquid suspension, which is convenient for patients to swallow, especially children and the elderly. The composition prepared by the present invention takes effect quickly and can relieve stomach pain, heartburn (heartburn), acid reflux and gastroesophageal reflux disease symptoms caused by excessive gastric acid within 10 minutes after taking it. The composition prepared by the present invention has a longer duration of action and can stay in the stomach for 4-6 hours, extending the contact and action time of the active ingredients for repairing the gastroesophageal mucosa with the gastric mucosa and duodenal mucosa. The present invention mainly acts locally and has high safety. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] Figure 1 This is a cross-sectional view of a rat stomach tissue sample.

[0033] Figure 2 For the spleen and stomach of rats 2*2cm 2 Cross-section of tissue samples. DETAILED DESCRIPTION

[0034] In order to better understand the present invention, the present invention is further described below in conjunction with specific examples. The terms used in the examples are for describing specific embodiments and do not constitute a limitation on the scope of protection of the present invention.

[0035] In the present invention:

[0036] PVM / MA is a cross-linked polymer of polyvinyl methyl ether / methyl acrylate and decadiene (decadiene cross-linked polymer); PVP is vinyl pyrrolidone; PVP / VA is a copolymer of vinyl pyrrolidone and vinyl acetate; HPMC is hydroxypropyl methylcellulose.

[0037] In the present invention, the viscosity is measured at 25° C. using a Bush viscometer at 20 RPM.

[0038] Example 1

[0039] A method for preparing a composition for repairing gastroesophageal mucosa comprises the following steps:

[0040] (1) Weigh the raw materials according to the following mass parts

[0041]

[0042]

[0043] (2) HPMC K100LV, PVP K90, and carbomer were placed in an appropriate amount of water, stirred, and fully dispersed. A pH regulator was added and stirred evenly to adjust the pH value and stir evenly to obtain a mixture 1.

[0044] (3) Sodium alginate, Physalis pseudocarpa colloid, sodium bicarbonate, methylparaben, and propylparaben were added to an appropriate amount of water and stirred to obtain a uniform mixture 2;

[0045] (4) Add mixture 2 to mixture 1, stir thoroughly, add active ingredients of traditional Chinese medicine for gastroesophageal mucosal repair, calcium carbonate, sweetener and flavor, replenish water, stir evenly, and fill.

[0046] The finished product was measured and found to have a viscosity of ≤500 mPa·s, a pH of 8.5, and a density of 0.99 g / ml.

[0047] Example 2

[0048] A method for preparing a composition for repairing gastroesophageal mucosa comprises the following steps:

[0049] (1) Weigh the raw materials according to the following mass parts

[0050]

[0051] (2) PVP K90 and carbomer were placed in water, stirred, and fully dispersed, a pH regulator was added, stirred evenly, the pH value was adjusted, and stirred evenly to obtain a mixture 1;

[0052] (3) Add appropriate amount of water to sodium alginate, sodium bicarbonate, methylparaben, and propylparaben, stir evenly, and prepare a uniform mixture 2;

[0053] (4) Add mixture 2 to mixture 1, stir thoroughly, add active ingredients of traditional Chinese medicine for gastroesophageal mucosal repair and calcium carbonate, sweetener, edible flavor, replenish water, stir evenly, and fill.

[0054] The finished product was measured and found to have a viscosity of ≤1150 mPa·s, a pH of 7.5, and a density of 1.06 g / ml.

[0055] Example 3

[0056] A method for preparing a composition for repairing gastroesophageal mucosa comprises the following steps:

[0057] (1) Weigh the raw materials according to the following mass parts

[0058]

[0059] (2) HPMC K100LV, NP700 sodium polyacrylate, and polycarbophil were placed in water, stirred, and fully dispersed. A pH regulator was added and stirred evenly to adjust the pH value and stir evenly to obtain a mixture 1;

[0060] (3) Add an appropriate amount of water to sodium alginate, sodium bicarbonate, and benzoic acid, and stir evenly to obtain a uniform mixture 2;

[0061] (4) Add mixture 2 to mixture 1, stir thoroughly, add active ingredients of traditional Chinese medicine for gastroesophageal mucosal repair, calcium carbonate and sweetener, make up the water, stir evenly, and fill.

[0062] The finished product was measured and found to have a viscosity of ≤230 mPa·s, a pH of 7.3, and a density of 0.96 g / ml.

[0063] Example 4

[0064] A method for preparing a composition for repairing gastroesophageal mucosa comprises the following steps:

[0065] (1) Weigh the raw materials according to the following mass parts

[0066]

[0067] (2) Carbomer is placed in water, stirred, and fully dispersed, a pH regulator is added, stirred evenly, the pH value is adjusted, and stirred evenly to obtain a mixture 1;

[0068] (3) Sodium alginate, Physalis sylvestris colloid, sodium bicarbonate, methylparaben, and propylparaben were added to an appropriate amount of water and stirred to obtain a uniform mixture 2;

[0069] (4) Add mixture 2 to mixture 1, stir thoroughly, add active ingredients of traditional Chinese medicine for gastroesophageal mucosal repair, calcium carbonate and sweetener, edible flavor, replenish water, stir evenly, and fill.

[0070] The finished product was measured and found to have a viscosity of ≤1280 mPa·s, a pH of 7.6, and a density of 1.10 g / ml.

[0071] Example 5

[0072] A method for preparing a composition for repairing gastroesophageal mucosa comprises the following steps:

[0073] (1) Weigh the raw materials according to the following mass parts

[0074]

[0075]

[0076] (2) Carbomer and PVP K90 were placed in water, stirred, and fully dispersed. A pH regulator was added and stirred evenly to adjust the pH value and stir evenly to obtain a mixture 1.

[0077] (3) Add an appropriate amount of water to sodium alginate and sodium bicarbonate and stir evenly to obtain a uniform mixture 2;

[0078] (4) Add mixture 2 to mixture 1, stir thoroughly, add active ingredients of traditional Chinese medicine for repairing gastroesophageal mucosa, calcium carbonate and sucralose, edible flavoring, add water, stir evenly, and fill.

[0079] The finished product was measured and found to have a viscosity of ≤1650 mPa·s, a pH of 9.3, and a density of 1.18 g / ml.

[0080] Example 6

[0081] A method for preparing a composition for repairing gastroesophageal mucosa comprises the following steps:

[0082] (1) Weigh the raw materials according to the following mass parts

[0083]

[0084] (2) Carbomer is placed in water, stirred, and fully dispersed, a pH regulator is added, stirred evenly, the pH value is adjusted, and stirred evenly to obtain a mixture 1;

[0085] (3) Sodium alginate, potassium bicarbonate, methylparaben, and propylparaben were added to an appropriate amount of water and stirred to obtain a uniform mixture 2;

[0086] (4) Add mixture 2 to mixture 1, stir thoroughly, add active ingredients of traditional Chinese medicine for gastroesophageal mucosal repair, calcium carbonate, polycarbophil calcium, saccharin calcium, edible flavoring, add water, stir evenly, and fill.

[0087] The finished product was measured and found to have a viscosity of ≤3850 mPa·s, a pH of 8.7, and a density of 1.06 g / ml.

[0088] Example 7

[0089] A method for preparing a composition for repairing gastroesophageal mucosa comprises the following steps:

[0090] (1) Weigh the raw materials according to the following mass parts

[0091]

[0092] (2) Carbomer is placed in water, stirred, and fully dispersed, a pH regulator is added, stirred evenly, the pH value is adjusted, and stirred evenly to obtain a mixture 1;

[0093] (3) Add appropriate amount of water to sodium alginate, sodium bicarbonate, methylparaben, and propylparaben, stir evenly, and prepare a uniform mixture 2;

[0094] (4) Add mixture 2 to mixture 1, stir thoroughly, add active ingredients of traditional Chinese medicine for gastroesophageal mucosal repair, calcium carbonate, polycarbophil calcium, saccharin sodium, edible flavoring, add water, stir evenly, and fill.

[0095] The finished product was measured and found to have a viscosity of ≤2950 mPa·s, a pH of 9.0, and a density of 1.01 g / ml.

[0096] Example 8

[0097] A method for preparing a composition for repairing gastroesophageal mucosa comprises the following steps:

[0098] (1) Weigh the raw materials according to the following mass parts

[0099]

[0100]

[0101] (2) Carbomer is placed in water, stirred, and fully dispersed, a pH regulator is added, stirred evenly, the pH value is adjusted, and stirred evenly to obtain a mixture 1;

[0102] (3) Sodium alginate, sodium bicarbonate, methylparaben, propylparaben, and a crystallization inhibitor are added with an appropriate amount of water and stirred to obtain a uniform mixture 2;

[0103] (4) Add mixture 2 to mixture 1, stir thoroughly, add active ingredients of traditional Chinese medicine for gastroesophageal mucosal repair, polycarbophil calcium, saccharin sodium, edible flavoring, add water, stir evenly, and fill.

[0104] The obtained composition preparation is an emulsion with a viscosity not exceeding 3350 mPa.s, a pH of 9.2, and a density of 1.01 g / ml. Example 9

[0105] (1) Weigh the raw materials according to the following mass parts

[0106]

[0107]

[0108] (2) PVM / MA (S97), xanthan gum, and chitosan are placed in water, stirred, and fully dispersed to obtain a uniform solution or suspension 1, and sodium hydroxide is added to adjust the pH value;

[0109] (3) Take part of vinyl pyrrolidone (PVP K30), vinyl pyrrolidone and vinyl acetate copolymer ( SR), HPMC E15, guar gum, zein, potassium bicarbonate, zinc carbonate, sodium carboxymethyl cellulose, cross-linked sodium carboxymethyl starch, cross-linked polyvinylpyrrolidone, cross-linked sodium carboxymethyl cellulose, low-substituted hydroxypropyl cellulose and benzoic acid, sweetener, are added to water and stirred to obtain a uniform mixture 2;

[0110] (4) Add mixture 2 to mixture 1, stir thoroughly, add the Chinese medicinal ingredients consisting of Atractylodes macrocephala, Dendrobium officinale, Hippophae rhamnoides, Atractylodes lancea, Tangerine peel, Bletilla striata and the remaining ingredients, stir evenly, and fill.

[0111] The obtained composition preparation is a suspension with a viscosity not exceeding 950 mPa.s, a pH value of 7.2, and a density of 9.82 g / ml.

[0112] The compositions of Examples 1 to 9 above were tested.

[0113] 1. In vitro artificial gastric fluid floating time test

[0114] Test Method: Fill a volumetric flask with 500 ml of pH 1.2 HCl buffer solution, approximately 1 cm below the constriction of the neck. Inject 10 ml of the test sample into the flask via syringe over a 10-second period. Start timing when all the gel floats to the surface. Stop timing. The results are shown in Table 1. Each test was repeated 10 times.

[0115] Table 1 Floating time limit

[0116] experimental group Adhesion time (minutes) Example 1 265±7 Example 2 102±4 Example 3 196±5 Example 4 227±6 Example 5 125±4 Example 6 135±3 Example 7 110±4 Example 8 106±2 Embodiment 9 156±3

[0117] 2. Release rate test

[0118] Test method: 500 ml of pH 1.2 hydrochloric acid buffer solution was added to a flat-bottomed flask with a neck. A magnetic stirring device was installed at the bottom of the flask, and a side port was used for sampling and rehydration. The flask was placed in a constant temperature water bath. When the buffer temperature reached 37°C ± 0.5°C, 10 ml of sample was added. The magnetic stirring was activated at 50 rpm / min. Samples were taken at 60, 120, 180, 240, and 360 minutes. The amount of gastroesophageal mucosal repair active ingredient at each sampling point was measured, and the release rate was calculated. The results are shown in Table 2. The test was repeated 10 times for each group.

[0119] Table 2 Release rate

[0120]

[0121] 3. Gastric mucosal damage repair ability test

[0122] Test method: 6 normal SD rats were taken as the normal control group, and 30 rats with acute gastric mucosal injury model (Note: The preparation of acute gastric mucosal injury model was to select 600g / L ethanol gavage to induce gastric mucosal injury model, that is, fasting but not water for 24h before modeling, and gavage with 600g / L ethanol, 2mL / rat.) were randomly divided into 5 groups, each with 6 rats, and used for experimental observation of model control group, commercial product control group, Example 1, Example 2, and Example 8 groups respectively. The normal control group and model control group were raised normally, and the commercial product control group, Example 1, Example 2, and Example 8 groups were given the corresponding test drugs, all of which were administered by gavage at 0.2mL / time (kg·d), 3 times / d, for 3 consecutive days.

[0123] 1) Gastric tissue samples were washed with physiological saline after ligation, fixed with 10% neutral formaldehyde for 10 minutes, cut open along the greater curvature of the stomach, cleaned of contents, removed of residual liquid, flattened, and the surface morphology observed and photographed.

[0124] The results are as follows Figure 1 As shown, normal gastric mucosal tissue is intact and rosy, with no visible ulcers, ulcer surfaces, or mucosal damage. The model control group showed severe gastric mucosal damage, with multiple brown congestion spots and multiple ulcer surfaces in the gastric body. The commercially available product control group showed significantly less gastric ulcer damage and a significantly smaller ulcer surface than the model control group.

[0125] Compared with the rats in Example 8, Example 2, Example 1 and the commercially available control group, the gastric wall damage of the rats was significantly alleviated, and the ulcer points and ulcer surfaces disappeared significantly.

[0126] 2) Gastric tissues of approximately 2*2 cm2 at the same location of the spleen and stomach of rats in each group were fixed with 10% neutral formaldehyde for 24 hours, embedded in paraffin, and sectioned. The sections were stained with conventional HE and the pathological changes of the gastric tissues were observed under a microscope.

[0127] The results showed that the normal gastric wall tissue mucosa was intact, with no ulcer points or ulcer surfaces, or mucosal damage.

[0128] In the model control group, the gastric mucosa of rats was mainly eroded and ulcerated, with mucosal epithelium shedding and severe inflammatory cell infiltration, which accumulated in the submucosa;

[0129] The gastric tissue congestion and edema of rats in the control group of the commercial product were significantly reduced, and the ulcer surface was significantly reduced;

[0130] Compared with the rats in Example 8, Example 2, Example 1 and the commercially available control group, the gastric tissues of the rats in the rat groups were nearly intact, the ulcer surface disappeared significantly, and the cell infiltration and tissue edema disappeared significantly.

[0131] 3) Ulcer inhibition rate

[0132] The area of each ulcer was measured with a vernier caliper. The ulcer area was calculated if the diameter was >1 mm. For ulcers with an area less than 1 mm, 10 points were equivalent to the ulcer surface and 1 mm. 2 The ulcer index was evaluated based on the square millimeters of the total ulcer area, and the ulcer inhibition percentage was calculated using the following formula:

[0133] Ulcer inhibition percentage = (total ulcer area of model control group - total ulcer area of drug-administered group) / total ulcer area of model control group * 100%.

[0134] Table 3 Comparison of ulcer inhibition rate

[0135]

[0136]

[0137] The ulcer inhibition rates of Example 8, Example 2, and Example 1 were all higher than that of the commercially available product control group.

[0138] 4. Expand the trial

[0139] The same method as in 3. Gastric mucosal injury repair ability test was used to test the remaining examples. The results are shown in Figure 4.

[0140] Table 4 Comparison of ulcer inhibition rate in expanded test

[0141] experimental group <![CDATA[Ulcer area (mm 2 )]]> Ulcer inhibition rate (%) Normal control group 0.00±0.00 100 Example 3 9.6±3.5 64.87 Example 4 9.4±3.2 66.81 Example 5 9.5±2.8 65.28 Example 6 9.6±3.4 66.31 Example 7 9.8±3.6 64.59 Example 9 8.9±2.7 67.01

[0142] The above detailed description is a specific description of one feasible embodiment of the present invention. This embodiment is not intended to limit the patent scope of the present invention. Any equivalent implementation or modification that does not depart from the present invention should be included in the scope of the technical solution of the present invention.

Claims

1. A method for preparing a liquid suspension for repairing gastroesophageal mucosa, characterized in that: The following steps are involved: (1) placing a bioadhesive material in a solvent, stirring uniformly, and adjusting the pH value to obtain a mixture 1; (2) adding a portion of the gastric floating retained components, pharmaceutically acceptable salts, and excipients to water and stirring uniformly to prepare a uniform mixture 2; (3) Add mixture 2 to mixture 1, stir thoroughly, add the active ingredient of traditional Chinese medicine for gastroesophageal mucosal repair and the remaining ingredients, make up the water, stir evenly, and fill to obtain the finished product; The gastroesophageal mucosal repair active ingredient is at least one of American cockroach extract, scutellaria baicalensis extract, yanhusuo extract, patchouli essential oil, licorice extract, atractylodes macrocephala extract, dendrobium extract, sea buckthorn extract, atractylodes lancea extract, tangerine peel extract, and bletilla striata extract; The bioadhesive material is selected from acrylic acid polymers, cellulose derivatives, povidone, polyvinyl methyl ether-maleic anhydride copolymer, natural gums and polysaccharides; The suspended retention component includes part a and part b; The part a is at least one of sodium alginate, physalis colloid, calcium polycarbophil, vinyl pyrrolidone, vinyl pyrrolidone and vinyl acetate copolymer, cellulose and its derivatives, acrylic acid polymer and its salt; The part b is sodium bicarbonate, calcium carbonate, potassium bicarbonate, zinc carbonate; sodium carboxymethyl cellulose, cross-linked sodium carboxymethyl starch, cross-linked polyvinylpyrrolidone, cross-linked sodium carboxymethyl cellulose, and low-substituted hydroxypropyl cellulose; The solvent is deionized water or a Class II / III solvent according to ICH; The finished product has a pH value of 5.0-9.5, a density of 0.9-1.2 g / ml, and a viscosity of ≤4000 mPa·s.

2. The method for preparing a liquid suspension according to claim 1, wherein The bioadhesive material is at least one of HPMC K100LV, PVM / MA, carbomer, polycarbophil, xanthan gum, chitosan, and vinyl pyrrolidone.

3. A liquid suspension for repairing gastroesophageal mucosa, characterized in that: The liquid suspension is prepared by the preparation method according to claim 1 or 2.

4. Use of the gastroesophageal mucosal repair liquid suspension according to claim 3 in the preparation of a medicine for alleviating stomach pain, heartburn, acid reflux caused by hyperacidity, improving gastroesophageal reflux disease, and repairing and protecting the digestive tract mucosa.

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