Active fresh dendrobium officinale freeze-dried powder and preparation process thereof

Abstract

The invention discloses active fresh dendrobium candidum freeze-dried powder and a preparation process, the formula comprises dendrobium candidum stems and dendrobium candidum flowers, and the preparation process comprises the following steps: step 1, pretreating the dendrobium candidum stems; step 2, freeze-drying the dendrobium stems; step 3, freeze-drying the dendrobium nobile flowers; step 4, powder preparation treatment; step 5, weighing the raw materials; step 6, mixing and sub-packaging; the dendrobium officinale flower freeze-dried powder is added into the formula of the dendrobium officinale freeze-dried powder, so that active ingredients lacking in stems are supplemented, and the freeze-dried powder has more comprehensive health-care functions; the dendrobium stem freeze-dried powder in different years and at different parts is scientifically proportioned, so that the main effects of the product are adjusted, and the requirements of different people are met; by adopting a step-by-step freeze-drying and mixing mode, not only is the stability of active ingredients of each part ensured, but also the proportion of key ingredients in a finished product can be accurately controlled, the fluctuation of active ingredients of products in different batches is reduced, and the standardization and homogenization of quality are realized.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, in particular to active fresh dendrobium officinale freeze-dried powder and a preparation process thereof. Background Art

[0002] Dendrobium officinale is a common Chinese medicinal herb with the benefits of nourishing the stomach, promoting fluid production, and clearing away heat. It is primarily used to treat symptoms such as febrile illnesses that damage fluids, dry mouth, and thirst, and insufficient stomach yin. With the deepening of research on Dendrobium officinale and the development of freeze-drying technology, freeze-dried Dendrobium officinale powder has emerged. Freeze-drying involves freezing the water contained in fresh Chinese medicinal herbs at low temperatures, then drying them under a vacuum environment. This allows the water to sublime directly from a solid state into water vapor and be removed from the finished product, thereby preserving the medicinal activity. Using freeze-drying technology to prepare freeze-dried Dendrobium officinale powder effectively prevents changes in the original physical, chemical, and biological properties of freshly prepared Dendrobium officinale, minimizing damage to the structure and characteristics of biological tissues and cells, and protecting the active ingredients of the herb. However, the existing freeze-dried powder of Dendrobium officinale still has the following shortcomings: 1. The existing freeze-dried powder of Dendrobium officinale only uses the stem of Dendrobium officinale as raw material, missing out on the unique efficacy of other parts, resulting in relatively limited functions; 2. The existing freeze-dried powder of Dendrobium officinale only uses Dendrobium officinale of a single year, and the composition of the freeze-dried powder tends to be the metabolites of a single stage, which cannot cover the medicinal properties of different years; 3. When preparing the existing freeze-dried powder of Dendrobium officinale, the whole stem of Dendrobium officinale is generally cut off and freeze-dried into powder, and then packaged. However, there is a large difference in the content of active ingredients in the base stem segment and the top stem segment. Therefore, the mixed powdering of the whole stem will cause the proportion of active ingredients in different batches of products to fluctuate greatly, and the product quality cannot be accurately controlled. Summary of the Invention

[0003] The purpose of the present invention is to provide an active fresh Dendrobium officinale freeze-dried powder and a preparation process to solve the problems raised in the above background technology.

[0004] To achieve the above object, the present invention provides the following technical solution: an active fresh Dendrobium officinale freeze-dried powder, the formula comprising: Dendrobium officinale stems and Dendrobium officinale flowers, the mass percentage content of each component being: 70-90% of Dendrobium officinale stems and 10-30% of Dendrobium officinale flowers.

[0005] Preferably, the mass percentage contents of the components are: 80% of Dendrobium officinale stem and 20% of Dendrobium officinale flower.

[0006] Preferably, the Dendrobium officinale stems used are one or more combinations of two-year-old, three-year-old, four-year-old and five-year-old.

[0007] A preparation process of active fresh Dendrobium officinale freeze-dried powder, comprising the following steps: 1, pre-treating the Dendrobium stems; 2, freeze-drying the Dendrobium stem segments; 3, freeze-drying the Dendrobium flowers; 4, powdering; 5, weighing the raw materials; and 6, mixing and packaging.

[0008] In the above step 1, fresh stems of Dendrobium officinale of the same growing year are cut into base stem segments, middle stem segments and top stem segments, the base stem segments, middle stem segments and top stem segments are then cut a second time, and the stem segments of the same year and the same position are placed in the same container;

[0009] In the above step 2, the container containing the stem segments is placed in a pre-freezing chamber for pre-freezing, and then transferred to a freeze dryer for freeze drying to obtain a freeze-dried product of the Dendrobium stem segments;

[0010] In the above step 3, fresh Dendrobium officinale flowers of the same year are placed in a freeze-drying tray, transferred to a pre-freezing bin for pre-freezing, and then transferred to a freeze dryer for freeze-drying to obtain a freeze-dried Dendrobium flower;

[0011] In the above step 4, the freeze-dried material of the stem segments of Dendrobium obtained in step 2 and the freeze-dried material of the flower of Dendrobium obtained in step 3 are respectively placed in a grinder for powdering, and the freeze-dried powder of the stem segments of Dendrobium obtained in step 2 and the freeze-dried material of the flower of Dendrobium obtained in step 3 are sieved to obtain freeze-dried powder of the stem segments of Dendrobium and freeze-dried powder of the flower of Dendrobium;

[0012] In the above step 5, taking the sum of the mass percentages of each component as 1, weigh the freeze-dried powder of dendrobium stem segments and the freeze-dried powder of dendrobium flowers according to the formula ratio;

[0013] In the above step 6, the freeze-dried powder of the stem segments of Dendrobium and the freeze-dried powder of the flowers of Dendrobium weighed in step 5 are placed in a mixer and mixed evenly, and then the mixed freeze-dried powder is vacuum-packed in a food-grade aluminum foil bag according to product specifications.

[0014] Preferably, in step one, for a three-year-old stem of Dendrobium officinale, the base stem segment accounts for 25% of the whole stem, the middle stem segment accounts for 50% of the whole stem, and the top stem segment accounts for 25% of the whole stem; for a four-year-old stem of Dendrobium officinale, the base stem segment accounts for 30% of the whole stem, the middle stem segment accounts for 45% of the whole stem, and the top stem segment accounts for 25% of the whole stem; for a five-year-old stem of Dendrobium officinale, the base stem segment accounts for 35% of the whole stem, the middle stem segment accounts for 40% of the whole stem, and the top stem segment accounts for 25% of the whole stem.

[0015] Preferably, in step 1, the length of the stem segments obtained by the secondary cutting is 1-4 cm.

[0016] Preferably, in the step 2, the pre-freezing treatment is specifically: pre-freezing at -30°C to -40°C for 4-5 hours; the freeze-drying treatment is specifically: controlling the vacuum degree at 10-30 Pa, heating to -15°C to -20°C at a rate of 0.5-1°C / min, and maintaining for 10-12 hours for sublimation drying; then heating to 20-25°C at a rate of 1-2°C / min, and maintaining for 7-9 hours for analytical drying.

[0017] Preferably, in the step three, the pre-freezing treatment is specifically: pre-freezing at -20°C to -30°C for 2-4 hours; the freeze-drying treatment is specifically: controlling the vacuum degree at 10-30 Pa, heating to -15°C to -20°C at a rate of 0.5-1°C / min, maintaining for 6-7 hours for sublimation drying; then heating to 20-25°C at a rate of 1-2°C / min, maintaining for 4-5 hours for analytical drying.

[0018] Preferably, in the step 4, the conditions for the powdering of the freeze-dried dendrobium flower are as follows: the pulverizer speed is 3000-5000 r / min, and the pulverization time is 3-5 min; the conditions for the powdering of the freeze-dried dendrobium stem segment are as follows: the pulverizer speed is 2000-3000 r / min, and the pulverization time is 8-12 min.

[0019] Preferably, in step 4, the particle size of the freeze-dried powder of dendrobium stem segments and the freeze-dried powder of dendrobium flowers is 50-70 mesh.

[0020] Compared with the prior art, the present invention has the following beneficial effects: the present invention supplements the active ingredients lacking in the stems by adding freeze-dried powder of dendrobium flower into the formula of freeze-dried powder of dendrobium officinale, so that the freeze-dried powder has more comprehensive health care functions; the main efficacy of the product is adjusted by scientifically proportioning freeze-dried powder of dendrobium stems from different years and different parts, thereby meeting the needs of different groups of people; the step-by-step freeze-drying and re-mixing method is adopted, which not only ensures the stability of the active ingredients in each part, but also can accurately control the proportion of key ingredients in the finished product, reduces the fluctuation of effective ingredients in different batches of products, and realizes standardization and homogenization of quality. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 It is a process flow chart of the present invention. DETAILED DESCRIPTION

[0022] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0023] Please see the attached Figure 1 , a technical solution provided by the present invention:

[0024] Example 1:

[0025] The invention discloses an active fresh Dendrobium officinale freeze-dried powder, which comprises: Dendrobium officinale stems and Dendrobium officinale flowers, wherein the mass percentage of each component is 80% of the Dendrobium officinale stems and 20% of the Dendrobium officinale flowers, and the Dendrobium officinale stems are 70% of four-year-old middle stem segments and 30% of four-year-old top stem segments.

[0026] A preparation process of active fresh Dendrobium officinale freeze-dried powder, comprising the following steps: 1, pre-treating the Dendrobium stems; 2, freeze-drying the Dendrobium stem segments; 3, freeze-drying the Dendrobium flowers; 4, powdering; 5, weighing the raw materials; and 6, mixing and packaging.

[0027] Wherein in the above step 1, fresh Dendrobium officinale stems of the same growing year are cut into base stem segments, middle stem segments and top stem segments, and then the base stem segments, middle stem segments and top stem segments are cut twice to obtain stem segments with a length of 1-4 cm, and the stem segments of the same year and the same position are put into the same container; wherein, for the Dendrobium officinale stem with a growing year of three years, the base stem segment accounts for 25% of the whole stem, the middle stem segment accounts for 50% of the whole stem, and the top stem segment accounts for 25% of the whole stem; for the Dendrobium officinale stem with a growing year of four years, the base stem segment accounts for 30% of the whole stem, the middle stem segment accounts for 45% of the whole stem, and the top stem segment accounts for 25% of the whole stem; for the Dendrobium officinale stem with a growing year of five years, the base stem segment accounts for 35% of the whole stem, the middle stem segment accounts for 40% of the whole stem, and the top stem segment accounts for 25% of the whole stem;

[0028] In the above step 2, the container containing the stem segment is placed in a pre-freezing chamber, pre-frozen at -30°C to -40°C for 4-5 hours, and then transferred to a freeze dryer, the vacuum degree is controlled at 10-30 Pa, the temperature is increased to -15°C to -20°C at a rate of 0.5-1°C / min, and maintained for 10-12 hours for sublimation drying; then the temperature is increased to 20-25°C at a rate of 1-2°C / min, and maintained for 7-9 hours for analytical drying to obtain a freeze-dried product of the Dendrobium stem segment;

[0029] In the above step 3, fresh Dendrobium officinale flowers of the same year are placed in a freeze-drying tray, transferred to a pre-freezing chamber, pre-frozen at -20°C to -30°C for 2-4 hours, and then transferred to a freeze dryer. The vacuum degree is controlled at 10-30 Pa, and the temperature is increased to -15°C to -20°C at a rate of 0.5-1°C / min, and maintained for 6-7 hours for sublimation drying; then the temperature is increased to 20-25°C at a rate of 1-2°C / min, and maintained for 4-5 hours for analytical drying to obtain a freeze-dried Dendrobium flower;

[0030] In the above step 4, the freeze-dried material of the stem of Dendrobium obtained in step 2 and the freeze-dried material of the flower of Dendrobium obtained in step 3 are respectively placed in a grinder for powdering, and after sieving, freeze-dried powder of the stem of Dendrobium and freeze-dried powder of Dendrobium flower with a particle size of 50-70 mesh are obtained; wherein the condition parameters for the powdering of the freeze-dried material of Dendrobium flower are: the speed of the grinder is 3000-5000 r / min, and the crushing time is 3-5 min; the condition parameters for the powdering of the freeze-dried material of Dendrobium stem are: the speed of the grinder is 2000-3000 r / min, and the crushing time is 8-12 min;

[0031] In the above step 5, taking the sum of the mass percentages of each component as 1, weigh the freeze-dried powder of dendrobium stem segments and the freeze-dried powder of dendrobium flowers according to the formula ratio;

[0032] In the above step 6, the freeze-dried powder of the stem segments of Dendrobium and the freeze-dried powder of the flowers of Dendrobium weighed in step 5 are placed in a mixer and mixed evenly, and then the mixed freeze-dried powder is vacuum-packed in a food-grade aluminum foil bag according to product specifications.

[0033] Example 2:

[0034] Referring to the formula and process of Example 1, only the mass percentage content of each component is changed to: 70% of Dendrobium officinale stems and 30% of Dendrobium officinale flowers, and the Dendrobium officinale stems use 70% of four-year-old middle stem segments and 30% of four-year-old top stem segments.

[0035] Example 3:

[0036] Referring to the formula and process of Example 1, only the mass percentage content of each component is changed to: 90% of Dendrobium officinale stems and 10% of Dendrobium officinale flowers, and the Dendrobium officinale stems use 70% of four-year-old middle stem segments and 30% of four-year-old top stem segments.

[0037] Example 4:

[0038] Referring to the formula and process of Example 1, only the mass percentage content of each component is changed to: 80% of Dendrobium officinale stems and 20% of Dendrobium officinale flowers, and the Dendrobium officinale stems use 70% of four-year-old middle stem segments and 30% of five-year-old base stem segments.

[0039] Example 5:

[0040] Referring to the formula and process of Example 1, only the mass percentage content of each component is changed to: 80% of Dendrobium officinale stems and 20% of Dendrobium officinale flowers, and the Dendrobium officinale stems use 70% of five-year-old middle stem segments and 30% of five-year-old top stem segments.

[0041] Example 6:

[0042] Referring to the formula and process of Example 1, only the mass percentage content of each component is changed to: 80% of Dendrobium officinale stems and 20% of Dendrobium officinale flowers, and the Dendrobium officinale stems use 90% of four-year-old middle stem segments and 10% of three-year-old base stem segments.

[0043] The effective components of the freeze-dried powder of Dendrobium officinale prepared in the above example are shown in the following table, wherein the control group is freeze-dried powder of the middle stem segment of a three-year-old plant:

[0044]

[0045]

[0046] Based on the above, the advantages of the present invention are: the present invention prepares freeze-dried powder by integrating stems and flowers of Dendrobium officinale of different years and different parts, thereby realizing the diversification of ingredients and the synergy of efficacy. On the one hand, the inclusion of Dendrobium officinale flowers supplements the active ingredients lacking in the stems, such as volatile oils and flavonoids, so that the freeze-dried powder has more comprehensive health care functions in terms of immune regulation, anti-inflammation, and tranquilization; on the other hand, the mixing of stem segments of different years takes into account the advantageous accumulation of dendrobium alkaloids, polysaccharides, and phenolic compounds in each growth stage, which can meet the segmented needs of different groups of people for clearing heat, nourishing yin, and anti-oxidation. In addition, the base, middle, and top stem segments are distinguished and freeze-dried separately, which avoids the imbalance of ingredient ratios caused by mixing the whole stem, effectively improves the product's pertinence in specific efficacy such as enhancing immunity, benefiting the stomach and promoting fluid production, and anti-oxidation, and significantly broadens the application scenarios.

[0047] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above and that the invention can be embodied in other specific forms without departing from the spirit or essential characteristics of the invention. Therefore, the embodiments should be considered in all respects as illustrative and non-restrictive, and the scope of the invention is defined by the appended claims, not the foregoing description, and all variations within the meaning and range of equivalents of the claims are intended to be included therein. Any reference sign in a claim should not be construed as limiting the claim to which it relates.

Claims

1. An active fresh freeze-dried powder of Dendrobium officinale, comprising: The Dendrobium officinale stem and Dendrobium officinale flower are characterized in that the mass percentage contents of the components are respectively 70-90% of the Dendrobium officinale stem and 10-30% of the Dendrobium officinale flower.

2. The active fresh Dendrobium officinale freeze-dried powder according to claim 1, characterized in that: The mass percentage contents of the components are respectively: 80% of the Dendrobium officinale stem and 20% of the Dendrobium officinale flower.

3. The active fresh Dendrobium officinale freeze-dried powder according to claim 1, characterized in that: The Dendrobium officinale stems are selected from one or more combinations of two-year-old, three-year-old, four-year-old and five-year-old.

4. A process for preparing active fresh Dendrobium officinale freeze-dried powder, comprising the steps of:

1. pre-treating the stems of Dendrobium officinale; 2. freeze-drying the stem segments of Dendrobium officinale; 3. freeze-drying the flowers of Dendrobium officinale; 4. powdering; 5. weighing the raw materials; and 6. mixing and packaging. The process is characterized in that: In the above step 1, fresh stems of Dendrobium officinale of the same growing year are cut into base stem segments, middle stem segments and top stem segments, the base stem segments, middle stem segments and top stem segments are then cut a second time, and the stem segments of the same year and the same position are placed in the same container; In the above step 2, the container containing the stem segments is placed in a pre-freezing chamber for pre-freezing, and then transferred to a freeze dryer for freeze-drying to obtain a freeze-dried product of the Dendrobium stem segments; In the above step 3, fresh Dendrobium officinale flowers of the same year are placed in a freeze-drying tray, transferred to a pre-freezing bin for pre-freezing, and then transferred to a freeze dryer for freeze-drying to obtain a freeze-dried Dendrobium flower; In the above step 4, the freeze-dried material of the stem segments of Dendrobium obtained in step 2 and the freeze-dried material of the flower of Dendrobium obtained in step 3 are respectively placed in a grinder for powdering, and the freeze-dried powder of the stem segments of Dendrobium obtained in step 2 and the freeze-dried material of the flower of Dendrobium obtained in step 3 are sieved to obtain freeze-dried powder of the stem segments of Dendrobium and freeze-dried powder of the flower of Dendrobium; In the above step 5, taking the sum of the mass percentages of each component as 1, weigh the freeze-dried powder of dendrobium stem segments and the freeze-dried powder of dendrobium flowers according to the formula ratio; In the above step 6, the freeze-dried powder of the stem segments of Dendrobium and the freeze-dried powder of the flowers of Dendrobium weighed in step 5 are placed in a mixer and mixed evenly, and then the mixed freeze-dried powder is vacuum-packed in a food-grade aluminum foil bag according to product specifications.

5. The preparation process of an active fresh Dendrobium officinale freeze-dried powder according to claim 4, characterized in that: In the step 1, for a three-year-old stem of Dendrobium officinale, the base stem segment accounts for 25% of the whole stem, the middle stem segment accounts for 50% of the whole stem, and the top stem segment accounts for 25% of the whole stem; for a four-year-old stem of Dendrobium officinale, the base stem segment accounts for 30% of the whole stem, the middle stem segment accounts for 45% of the whole stem, and the top stem segment accounts for 25% of the whole stem; for a five-year-old stem of Dendrobium officinale, the base stem segment accounts for 35% of the whole stem, the middle stem segment accounts for 40% of the whole stem, and the top stem segment accounts for 25% of the whole stem.

6. The process for preparing an active fresh freeze-dried powder of Dendrobium officinale according to claim 4, characterized in that: In the step 1, the stem segments obtained by the secondary cutting have a length of 1-4 cm.

7. The process for preparing an active fresh freeze-dried powder of Dendrobium officinale according to claim 4, characterized in that: In the step 2, the pre-freezing treatment is specifically as follows: pre-freezing at -30°C to -40°C for 4-5 hours; the freeze-drying treatment is specifically as follows: controlling the vacuum degree at 10-30 Pa, heating to -15°C to -20°C at a rate of 0.5-1°C / min, maintaining for 10-12 hours for sublimation drying; then heating to 20-25°C at a rate of 1-2°C / min, maintaining for 7-9 hours for analytical drying.

8. The process for preparing an active fresh freeze-dried powder of Dendrobium officinale according to claim 4, characterized in that: In the step three, the pre-freezing treatment is specifically as follows: pre-freezing at -20°C to -30°C for 2-4 hours; the freeze-drying treatment is specifically as follows: controlling the vacuum degree at 10-30 Pa, heating to -15°C to -20°C at a rate of 0.5-1°C / min, maintaining for 6-7 hours for sublimation drying; then heating to 20-25°C at a rate of 1-2°C / min, maintaining for 4-5 hours for analytical drying.

9. The process for preparing an active fresh freeze-dried powder of Dendrobium officinale according to claim 4, characterized in that: In the step 4, the conditions for the powdering of the freeze-dried dendrobium flower are as follows: the speed of the grinder is 3000-5000 r / min, and the crushing time is 3-5 min; the conditions for the powdering of the freeze-dried dendrobium stem segment are as follows: the speed of the grinder is 2000-3000 r / min, and the crushing time is 8-12 min.

10. The process for preparing an active fresh freeze-dried powder of Dendrobium officinale according to claim 4, characterized in that: In the step 4, the particle size of the freeze-dried powder of the dendrobium stem segments and the freeze-dried powder of the dendrobium flowers is 50-70 mesh.

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