Pill for relieving cough and reducing phlegm and preparation method thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a cough relieving and phlegm reducing pill and a preparation method thereof.The cough relieving and phlegm reducing pill is prepared from basic medicinal materials and auxiliary medicinal materials; the basic herbs comprise radix asteris, rhizoma anemarrhenae, radix ophiopogonis, radix scutellariae, lily, radix scrophulariae, angelica sinensis, fructus perillae, schisandra chinensis, radix rehmanniae, radix stemonae, exocarpium citri rubrum, flos farfarae, fermented pinellia, radix asparagi, radix trichosanthis, cortex mori radicis, bulbus fritillariae cirrhosae, radix peucedani, inula flower, platycodon grandiflorum, liquorice, fructus gardeniae and semen armeniacae amarae; the auxiliary medicinal materials comprise at least four of gingko, rhizoma arisaematis, trichosanthes kirilowii maxim, snow lotus herb, cynanchum glaucescens, momordica grosvenori, rhodiola rosea, azalea leaf, mulberry leaf, boat-fruited sterculia seed, loquat leaf and artemisia dubia. The cough-relieving and phlegm-reducing pill provided by the invention can obviously prolong the cough latency period, reduce the cough frequency and effectively increase the phenol red excretion amount of trachea, has obvious cough-relieving and phlegm-reducing effects, is black brown in appearance and uniform in color, and has the yield of 90% or above.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and in particular to a Ningsou Huatan pill and a preparation method thereof. Background Art

[0002] Cough is a common clinical respiratory symptom, often associated with a variety of factors, including colds, bronchitis, and allergies. From a physiological perspective, coughing is an important defense mechanism for the respiratory tract, effectively clearing inhaled foreign matter and secretions retained in the respiratory tract. However, severe and persistent coughing can not only cause significant discomfort, disrupt sleep and rest, and significantly reduce quality of life, but can also cause respiratory tissue damage, dysfunction, and even induce a variety of systemic complications.

[0003] At present, although there are a wide variety of cough and expectorant drugs on the market, on the one hand, although traditional formula drugs have certain cough and expectorant effects, they generally have the disadvantage of limited efficacy; on the other hand, in the process production link, the problems of unstable finished product quality and low finished product rate also urgently need to be solved to make the production process more economical.

[0004] Chinese invention patent application CN107126493A provides a traditional Chinese medicine pill for relieving phlegm and cough and its preparation method. The main medicinal ingredients are rhubarb, realgar stone, agarwood, pinellia tuber, dried tangerine peel, and scutellaria baicalensis. After processing, the pills are sterilized and crushed into powder before being kneaded into pills for convenient consumption by patients. However, the traditional Chinese medicine pills prepared using this method still have difficulty in resolving the problem of low yield. Summary of the Invention

[0005] In order to solve the problems in the prior art, the present invention provides a Ningsou Huatan Pill in a first aspect. The raw materials for preparing the Ningsou Huatan Pill include basic medicinal materials and auxiliary medicinal materials; the basic medicinal materials include Aster tataricus L.f., Anemarrhena asphodeloides Bunge, Ophiopogon japonicus (Lf) Ker Gawl., Scutellaria baicalensis Georgi, Lilium brownievar. viridulum Baker, Scrophulariae Radix, Angelica sinensis (Oliv.) Diels, Perilla frutescens (L.) Britt., Schisandra chinensis (Turcz.) Baill., Rehmannia glutinosa (Gaertn.) Libosch. ex Fisch. & C.A. Mey., Stemona officinalis (Stemona radix) japonica (Blume) Miq.), Citrus exocarpium rubrum, Coltsfoot flower (Farfarae Flos), Pinellia tuber (FERMENTATA RHIZOMATISPINELLIAE MASSA), Asparagus densiflorus (Kunth) Jessop, Radix Trichosanthis, Morus alba L., Fritillaria cirrhosa D.Don, Peucedanum praeruptorum Dunn, Inula japonica Thunb., Platycodon grandiflorus (Jacq.) A.DC., Glycyrrhiza uralensis Fisch., Gardenia jasminoides J.Ellis and Bitter almond (Semen Armeniacae Amarum); the auxiliary medicinal materials include Ginkgo biloba L.), Arisaema heterophyllum Blume, Trichosanthes kirilowii Maxim., Saussurea involucrata, Kar.&Kir., Sch.Bip.At least four of the following: ( ), Vincetoxicum glaucescens (Decne.) C.Y.Wu & D.Z.Li ), Siraitia grosvenorii (Swingle) C.Jeffrey ex Lu et Z.Y.Zhang , Rhodiola rosea L. , azalea leaves, Morus alba L. , Sterculia dahurica (Scaphium wallichii (Wall.ex G.Don) Schott & Endl. ), loquat leaves (Eriobotrya japonica Thunb. ), and Artemisia dubia Wall.ex Besser .

[0006] In one embodiment, the mass ratio of the basic medicinal materials to the auxiliary medicinal materials is (14-16): 1. Examples thereof include 14:1, 15:1, 15.25:1, and 16:1.

[0007] In one embodiment, the auxiliary medicinal materials include ginkgo, arisaema, trichosanthes kirilowii, and snow lotus, and the mass ratio of ginkgo, arisaema, trichosanthes kirilowii, and snow lotus is (1-2): (1-2): (1-2): (1-2), which can be 1:1:1:1, 1:2:2:1, or 1:1:2:1.

[0008] The present application creatively adds auxiliary medicinal materials ginkgo, arisaema, trichosanthes kirilowii and snow lotus to traditional formula medicines, and further controls the mass ratio of ginkgo, arisaema, trichosanthes kirilowii and snow lotus to be (1-2): (1-2): (1-2): (1-2), which can further improve the cough and phlegm-relieving effect of the medicine and improve the finished product rate of the medicine. The possible reason is that, on the one hand, at this mass ratio, the trichosanthes kirilowii polysaccharide and snow lotus cellulose in the auxiliary medicinal materials can enhance the adhesion of the powder and reduce the cracking of the pellets, and the arisaema starch and ginkgo flavonoids can improve the fluidity of the powder, ensure mixing uniformity, and reduce the difference in pill weight; on the other hand, the four auxiliary medicinal materials at this mass ratio form a "tussive-phlegm-relieving-anti-inflammatory-immunomodulatory" synergistic effect, avoiding the imbalance of drug efficacy caused by excessive dosage of a single component.

[0009] In one embodiment, the auxiliary medicinal materials include Baiqian, Momordica grosvenori, Rhodiola rosea, and Azalea leaves, and the mass ratio of Baiqian, Momordica grosvenori, Rhodiola rosea, and Azalea leaves is (1-2): (1-2): (1-2): (1-2), which can be exemplified by 1:1:1:1, 1:2:2:1, and 1:1:2:1.

[0010] This application adds auxiliary medicinal materials such as Baiqian, Momordica grosvenori, Rhodiola rosea and azalea leaves. Baiqian is slightly warm, Momordica grosvenori is cool, Rhodiola rosea is neutral and azalea leaves are slightly warm. The cold and hot properties of the four medicines are balanced to avoid excessive bias of a single medicinal property. At the same time, Baiqian and azalea leaves can resolve phlegm and lower qi, Rhodiola rosea can invigorate qi and promote blood circulation, and Momordica grosvenori can nourish yin and moisten dryness. The combination of the four and the basic medicinal materials synergistically optimizes the effect of relieving cough and resolving phlegm. On the other hand, Momordica grosvenori contains a large amount of fructose and polysaccharides. If the dosage is too high, the viscosity of the powder will increase sharply, and technical problems such as difficulty in molding will easily occur during refining. When the mass ratio of Baiqian, Momordica grosvenori, Rhodiola rosea and azalea leaves is (1-2): (1-2): (1-2): (1-2), the fructose in the system forms a physical dispersion with the fibrous components of other medicinal materials to ensure the plasticity of the pills.

[0011] In one embodiment, the auxiliary medicinal materials include mulberry leaves, pteridophytum corylifolia, loquat leaves, and Artemisia selengensis, and the mass ratio of the mulberry leaves, pteridophytum corylifolia, loquat leaves, and Artemisia selengensis is (1-2): (1-2): (1-2): (1-2), which can be exemplified as 1:1:1:1, 1:2:2:1, and 1:1:2:1.

[0012] In this application, auxiliary medicinal materials such as mulberry leaves, sterculia lychnophora, loquat leaves and oxtail wormwood are added to the basic medicinal materials for compounding. Through the synergistic effect of the four medicinal materials of mulberry leaves, sterculia lychnophora, loquat leaves and oxtail wormwood, the inflammatory response can be effectively inhibited, while the cough symptoms are alleviated and the cough incubation period is significantly prolonged.

[0013] A second aspect of the present invention provides a method for preparing Ningsou Huatan Pills, comprising at least the following steps:

[0014] The raw materials are pre-treated, crushed, sieved and mixed to form drug powder;

[0015] The medicinal powder is mixed with refined honey to prepare pills, thereby obtaining the Ningsou Huatan pills.

[0016] In one embodiment, the pretreatment includes washing and drying the basic medicinal materials and the auxiliary medicinal materials respectively; in the drying process, the drying temperature of angelica does not exceed 60°C, and the drying temperature of other preparation raw materials does not exceed 80°C.

[0017] In one embodiment, the drying process is to sequentially perform drying in an electric heating drying room and a steam heating drying room.

[0018] In one embodiment, the drying time of the electrically heated drying room is 3-4 hours.

[0019] In one embodiment, the drying time in the steam-heated drying room is 10-12 hours.

[0020] In one embodiment, during the cleaning process, the scutellaria baicalensis needs to be boiled in boiling water for 10 minutes or steamed for half an hour, and the remaining medicinal materials can be cleaned with drinking water.

[0021] In this application, the flower and leaf medicinal materials (such as aster, coltsfoot, inula, etc.) and some rhizome medicinal materials in the preparation raw materials are first dried preliminarily in an electric heating drying room, which can quickly evaporate the moisture on the surface of the medicinal materials, and prevent the flower and leaf medicinal materials from becoming moldy or losing effective ingredients due to a long-term hot and humid environment; then the medicinal materials are deeply dried in a steam heating drying room, and the hot and humid environment of steam is used to achieve a sterilization effect, which meets the pharmaceutical hygiene standards.

[0022] In one embodiment, the refined honey is made from honey, the refining time is 15-30 minutes, and the temperature is 80-90° C. The honey is multifloral honey.

[0023] In one embodiment, the mass ratio of the medicinal powder to refined honey is 1:(1-1.2).

[0024] In the present application, the temperature of refining honey is controlled to be 80-90°C, and the mass ratio of medicinal powder to refined honey is limited to 1:(1.1-1.2), which can ensure that the appearance color of the prepared Ningsou Huatan Pills is uniform and dark brown, while improving the cost rate of Ningsou Huatan Pills. On the one hand, if the mass ratio of medicinal powder to refined honey is too high, the pills will be too soft, easy to stick and deform, and difficult to shape; if the mass ratio of medicinal powder to refined honey is too low, the pills will be loose and easy to break, the surface of the finished product will be rough, and the pills will be prone to cracking. On the other hand, if the temperature of refining honey is too high, the pills will easily crack, have high hardness, and be black in color; while if the temperature is too low, it will easily make the pills difficult to shape.

[0025] Beneficial effects

[0026] 1. The present application creatively adds auxiliary medicinal materials ginkgo, arisaema, trichosanthes kirilowii and snow lotus to traditional formula medicines, and further controls the mass ratio of ginkgo, arisaema, trichosanthes kirilowii and snow lotus to (1-2): (1-2): (1-2): (1-2), which can further improve the cough and phlegm-relieving effect of the medicine and increase the finished product rate of the medicine.

[0027] 2. This application avoids excessive bias in the properties of a single drug by adding auxiliary medicinal materials such as white qianqian, momordica grosvenori, rhodiola rosea and azalea leaves, and synergizes with the basic medicinal materials to optimize the cough and phlegm-relieving effects while ensuring the plasticity of the pills.

[0028] 3. In this application, auxiliary medicinal materials such as mulberry leaves, sterculia lychnophora, loquat leaves and oxtail wormwood are added to the basic medicinal materials for compounding. Through the synergistic effect of the four medicinal materials of mulberry leaves, sterculia lychnophora, loquat leaves and oxtail wormwood, the inflammatory response can be effectively inhibited, while the cough symptoms are alleviated and the cough incubation period is significantly prolonged.

[0029] 4. The drying process of this application is to sequentially pass through an electric heating drying room and a steam heating drying room for drying, which can prevent the flower and leaf medicinal materials from becoming moldy or losing their effective ingredients due to a long-term hot and humid environment, and at the same time achieve a sterilization effect.

[0030] 5. In this application, the temperature of refined honey is controlled at 80-90°C, and the mass ratio of medicinal powder to refined honey is limited to 1: (1.1-1.2), which can ensure that the appearance color of the prepared Ningsou Huatan Pills is uniform and dark brown, while improving the finished product rate of Ningsou Huatan Pills. DETAILED DESCRIPTION

[0031] In order to make the purpose, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the examples. It should be understood that the specific examples described herein are only used to explain the present invention and are not intended to limit the present invention. The experimental methods in the examples where specific conditions are not specified were carried out according to conventional conditions or the conditions recommended by the manufacturer. The reagents used where the manufacturer is not specified are all conventional products that can be purchased commercially.

[0032] Example 1

[0033] A first aspect of the present embodiment provides a Ningsou Huatan Pill, wherein the raw materials for preparing the Ningsou Huatan Pill include basic medicinal materials and auxiliary medicinal materials; the basic medicinal materials are 50g of Aster tataricus, 25g of Anemarrhena asphodeloides, 40g of Ophiopogon japonicus, 10g of Scutellaria baicalensis, 40g of Lilium, 10g of Scrophularia ningpoensis, 25g of Angelica sinensis, 10g of Perilla seed, 25g of Schisandra chinensis, 50g of Rehmannia glutinosa, 20g of Stemona tuber, 40g of Citrus aurantium, 10g of Coltsfoot Flos, 25g of Pinellia tuber, 10g of Asparagus cochinchinensis, 25g of Radix Trichosanthis, 50g of Morus alba bark, 25g of Fritillaria cirrhosa, 40g of Peucedanum peucedanum, 10g of Inula flower, 25g of Platycodon grandiflorum, 10g of Liquorice root, 25g of Gardenia jasminoides, and 10g of Apricot kernel;

[0034] The auxiliary medicinal materials are 10g of Ginkgo biloba, 10g of Arisaema consanguineum, 10g of Trichosanthes kirilowii and 10g of Snow Lotus.

[0035] A second aspect of this embodiment provides a method for preparing Ningsou Huatan Pills, comprising the following steps:

[0036] The raw materials are pre-treated, crushed, sieved and mixed to form drug powder;

[0037] The medicinal powder is mixed with refined honey to prepare pills, thereby obtaining the Ningsou Huatan pills.

[0038] The pretreatment includes cleaning and drying the basic medicinal materials and the auxiliary medicinal materials respectively; during the cleaning process, the scutellaria baicalensis needs to be boiled in boiling water for 10 minutes, and the other medicinal materials can be cleaned with drinking water.

[0039] The drying process is to sequentially perform drying in an electric heating drying room for 3 hours and a steam heating drying room for 10 hours.

[0040] The drying temperature of the angelica in the drying process is 50° C., and the drying temperature of other raw materials is 70° C.

[0041] The honey is made from multi-flower honey, with a refining time of 20 minutes and a temperature of 80°C.

[0042] The mass ratio of the medicinal powder to the refined honey is 1:1.

[0043] Example 2

[0044] A first aspect of the present embodiment provides a Ningsou Huatan Pill, wherein the raw materials for preparing the Ningsou Huatan Pill include basic medicinal materials and auxiliary medicinal materials; the basic medicinal materials are 50g of Aster tataricus, 25g of Anemarrhena asphodeloides, 40g of Ophiopogon japonicus, 10g of Scutellaria baicalensis, 40g of Lilium, 10g of Scrophularia ningpoensis, 25g of Angelica sinensis, 10g of Perilla seed, 25g of Schisandra chinensis, 50g of Rehmannia glutinosa, 20g of Stemona tuber, 40g of Citrus aurantium, 10g of Coltsfoot Flos, 25g of Pinellia tuber, 10g of Asparagus cochinchinensis, 25g of Radix Trichosanthis, 50g of Morus alba bark, 25g of Fritillaria cirrhosa, 40g of Peucedanum peucedanum, 10g of Inula flower, 25g of Platycodon grandiflorum, 10g of Liquorice root, 25g of Gardenia jasminoides, and 10g of Apricot kernel;

[0045] The auxiliary medicinal materials are 10g of Baiqian, 10g of Momordica grosvenori, 10g of Rhodiola rosea and 10g of Azalea leaves.

[0046] A second aspect of this embodiment provides a method for preparing Ningsou Huatan Pills, comprising the following steps:

[0047] The raw materials are pre-treated, crushed, sieved and mixed to form drug powder;

[0048] The medicinal powder is mixed with refined honey to prepare pills, thereby obtaining the Ningsou Huatan pills.

[0049] The pretreatment includes cleaning and drying the basic medicinal materials and the auxiliary medicinal materials respectively; during the cleaning process, the scutellaria baicalensis needs to be boiled in boiling water for 10 minutes, and the other medicinal materials can be cleaned with drinking water.

[0050] The drying process is to sequentially perform drying in an electric heating drying room for 3 hours and a steam heating drying room for 10 hours.

[0051] The drying temperature of the angelica in the drying process is 50° C., and the drying temperature of other raw materials is 70° C.

[0052] The honey is made from multi-flower honey, with a refining time of 20 minutes and a temperature of 80°C.

[0053] The mass ratio of the medicinal powder to the refined honey is 1:1.1.

[0054] Example 3

[0055] A first aspect of the present embodiment provides a Ningsou Huatan Pill, wherein the raw materials for preparing the Ningsou Huatan Pill include basic medicinal materials and auxiliary medicinal materials; the basic medicinal materials are 50g of Aster tataricus, 25g of Anemarrhena asphodeloides, 40g of Ophiopogon japonicus, 10g of Scutellaria baicalensis, 40g of Lilium, 10g of Scrophularia ningpoensis, 25g of Angelica sinensis, 10g of Perilla seed, 25g of Schisandra chinensis, 50g of Rehmannia glutinosa, 20g of Stemona tuber, 40g of Citrus aurantium, 10g of Coltsfoot Flos, 25g of Pinellia tuber, 10g of Asparagus cochinchinensis, 25g of Radix Trichosanthis, 50g of Morus alba bark, 25g of Fritillaria cirrhosa, 40g of Peucedanum peucedanum, 10g of Inula flower, 25g of Platycodon grandiflorum, 10g of Liquorice root, 25g of Gardenia jasminoides, and 10g of Apricot kernel;

[0056] The auxiliary medicinal materials are 10g of mulberry leaves, 10g of sterculia lychnophora, 10g of loquat leaves and 10g of oxtail wormwood.

[0057] A second aspect of this embodiment provides a method for preparing Ningsou Huatan Pills, comprising the following steps:

[0058] The raw materials are pre-treated, crushed, sieved and mixed to form drug powder;

[0059] The medicinal powder is mixed with refined honey to prepare pills, thereby obtaining the Ningsou Huatan pills.

[0060] The pretreatment includes cleaning and drying the basic medicinal materials and the auxiliary medicinal materials respectively; during the cleaning process, the scutellaria baicalensis needs to be boiled in boiling water for 10 minutes, and the other medicinal materials can be cleaned with drinking water.

[0061] The drying process is to sequentially perform drying in an electric heating drying room for 3 hours and a steam heating drying room for 10 hours.

[0062] The drying temperature of the angelica in the drying process is 50° C., and the drying temperature of other raw materials is 70° C.

[0063] The honey is made from multi-flower honey, with a refining time of 20 minutes and a temperature of 80°C.

[0064] The mass ratio of the medicinal powder to the refined honey is 1:1.2.

[0065] Comparative Example 1

[0066] The first aspect of this comparative example provides a Ningsou Huatan Pill, the raw materials for preparing the Ningsou Huatan Pill are basic medicinal materials; the basic medicinal herbs are 50g of Aster tataricus, 25g of Anemarrhena asphodeloides, 40g of Ophiopogon japonicus, 10g of Scutellaria baicalensis, 40g of Lilium, 10g of Scrophularia ningpoensis, 25g of Angelica sinensis, 10g of Perilla seed, 25g of Schisandra chinensis, 50g of Rehmannia glutinosa, 20g of Stemona bulb, 40g of Citrus aurantium, 10g of Coltsfoot flower, 25g of Pinellia tuber, 10g of Asparagus cochinchinensis, 25g of Radix Trichosanthis, 50g of Morus alba bark, 25g of Fritillaria cirrhosa, 40g of Peucedanum peucedanum, 10g of Inula flower, 25g of Platycodon grandiflorum, 10g of Liquorice, 25g of Gardenia jasminoides and 10g of bitter almond.

[0067] The second aspect of this comparative example provides a method for preparing Ningsou Huatan Pills, comprising the following steps:

[0068] The raw materials are pre-treated, crushed, sieved and mixed to form drug powder;

[0069] The medicinal powder is mixed with refined honey to prepare pills, thereby obtaining the Ningsou Huatan pills.

[0070] The pretreatment includes cleaning and drying the basic medicinal materials and the auxiliary medicinal materials respectively; during the cleaning process, the scutellaria baicalensis needs to be boiled in boiling water for 10 minutes, and the other medicinal materials can be cleaned with drinking water.

[0071] The drying process is to sequentially perform drying in an electric heating drying room for 3 hours and a steam heating drying room for 10 hours.

[0072] The drying temperature of the angelica in the drying process is 50° C., and the drying temperature of other raw materials is 70° C.

[0073] The honey is made from multi-flower honey, with a refining time of 20 minutes and a temperature of 80°C.

[0074] The mass ratio of the medicinal powder to the refined honey is 1:1.

[0075] Comparative Example 2

[0076] The first aspect of the present comparative example provides a Ningsou Huatan Pill, wherein the raw materials for preparing the Ningsou Huatan Pill include basic medicinal materials and auxiliary medicinal materials; the basic medicinal materials are 50g of Aster, 25g of Anemarrhena, 40g of Ophiopogon, 10g of Scutellaria, 40g of Lilium, 10g of Scrophularia, 25g of Angelica, 10g of Perilla, 25g of Schisandra, 50g of Rehmannia, 20g of Stemona, 40g of Citrus aurantium, 10g of Coltsfoot Flos, 25g of Pinellia, 10g of Asparagus, 25g of Radix Trichosanthis, 50g of Morus alba, 25g of Fritillaria cirrhosa, 40g of Peucedanum, 10g of Inula, 25g of Platycodon, 10g of Liquorice, 25g of Gardenia, and 10g of Apricot Kernel;

[0077] The auxiliary medicinal materials are 50g of Ginkgo biloba, 10g of Arisaema consanguineum and 10g of Snow Lotus.

[0078] The second aspect of this comparative example provides a method for preparing Ningsou Huatan Pills, comprising the following steps:

[0079] The raw materials are pre-treated, crushed, sieved and mixed to form drug powder;

[0080] The medicinal powder is mixed with refined honey to prepare pills, thereby obtaining the Ningsou Huatan pills.

[0081] The pretreatment includes cleaning and drying the basic medicinal materials and the auxiliary medicinal materials respectively; during the cleaning process, the scutellaria baicalensis needs to be boiled in boiling water for 10 minutes, and the other medicinal materials can be cleaned with drinking water.

[0082] The drying process is to sequentially perform drying in an electric heating drying room for 3 hours and a steam heating drying room for 10 hours.

[0083] The drying temperature of the angelica in the drying process is 50° C., and the drying temperature of other raw materials is 70° C.

[0084] The honey is made from multi-flower honey, with a refining time of 20 minutes and a temperature of 80°C.

[0085] The mass ratio of the medicinal powder to the refined honey is 1:1.

[0086] Comparative Example 3

[0087] The first aspect of the present comparative example provides a Ningsou Huatan Pill, wherein the raw materials for preparing the Ningsou Huatan Pill include basic medicinal materials and auxiliary medicinal materials; the basic medicinal materials are 50g of Aster, 25g of Anemarrhena, 40g of Ophiopogon, 10g of Scutellaria, 40g of Lilium, 10g of Scrophularia, 25g of Angelica, 10g of Perilla, 25g of Schisandra, 50g of Rehmannia, 20g of Stemona, 40g of Citrus aurantium, 10g of Coltsfoot Flos, 25g of Pinellia, 10g of Asparagus, 25g of Radix Trichosanthis, 50g of Morus alba, 25g of Fritillaria cirrhosa, 40g of Peucedanum, 10g of Inula, 25g of Platycodon, 10g of Liquorice, 25g of Gardenia, and 10g of Apricot Kernel;

[0088] The auxiliary medicinal materials are 10g of Radix Bletillae, 50g of Momordica grosvenori and 10g of Rhododendron chinense leaves.

[0089] The second aspect of this comparative example provides a method for preparing Ningsou Huatan Pills, comprising the following steps:

[0090] The raw materials are pre-treated, crushed, sieved and mixed to form drug powder;

[0091] The medicinal powder is mixed with refined honey to prepare pills, thereby obtaining the Ningsou Huatan pills.

[0092] The pretreatment includes cleaning and drying the basic medicinal materials and the auxiliary medicinal materials respectively; during the cleaning process, the scutellaria baicalensis needs to be boiled in boiling water for 10 minutes, and the other medicinal materials can be cleaned with drinking water.

[0093] The drying process is to sequentially perform drying in an electric heating drying room for 3 hours and a steam heating drying room for 10 hours.

[0094] The drying temperature of the angelica in the drying process is 50° C., and the drying temperature of other raw materials is 70° C.

[0095] The honey is made from multi-flower honey, with a refining time of 20 minutes and a temperature of 80°C.

[0096] The mass ratio of the medicinal powder to the refined honey is 1:1.

[0097] Comparative Example 4

[0098] The first aspect of the present comparative example provides a Ningsou Huatan Pill, wherein the raw materials for preparing the Ningsou Huatan Pill include basic medicinal materials and auxiliary medicinal materials; the basic medicinal materials are 50g of Aster, 25g of Anemarrhena, 40g of Ophiopogon, 10g of Scutellaria, 40g of Lilium, 10g of Scrophularia, 25g of Angelica, 10g of Perilla, 25g of Schisandra, 50g of Rehmannia, 20g of Stemona, 40g of Citrus aurantium, 10g of Coltsfoot Flos, 25g of Pinellia, 10g of Asparagus, 25g of Radix Trichosanthis, 50g of Morus alba, 25g of Fritillaria cirrhosa, 40g of Peucedanum, 10g of Inula, 25g of Platycodon, 10g of Liquorice, 25g of Gardenia, and 10g of Apricot Kernel;

[0099] The auxiliary medicinal materials are 10g of mulberry leaves, 50g of sterculia lychnophora and 10g of loquat leaves.

[0100] The second aspect of this comparative example provides a method for preparing Ningsou Huatan Pills, comprising the following steps:

[0101] The raw materials are pre-treated, crushed, sieved and mixed to form drug powder;

[0102] The medicinal powder is mixed with refined honey to prepare pills, thereby obtaining the Ningsou Huatan pills.

[0103] The pretreatment includes cleaning and drying the basic medicinal materials and the auxiliary medicinal materials respectively; during the cleaning process, the scutellaria baicalensis needs to be boiled in boiling water for 10 minutes, and the other medicinal materials can be cleaned with drinking water.

[0104] The drying process is to sequentially perform drying in an electric heating drying room for 3 hours and a steam heating drying room for 10 hours.

[0105] The drying temperature of the angelica in the drying process is 50° C., and the drying temperature of other raw materials is 70° C.

[0106] The honey is made from multi-flower honey, with a refining time of 20 minutes and a temperature of 80°C.

[0107] The mass ratio of the medicinal powder to the refined honey is 1:1.

[0108] Comparative Example 5

[0109] The specific implementation of this comparative example is basically the same as that of Example 1, except that the drying temperature of the angelica in the drying process is 70°C.

[0110] Comparative Example 6

[0111] The specific implementation of this comparative example is basically the same as that of Example 1, except that the drying process is carried out in an electrically heated drying room for 3 hours.

[0112] Comparative Example 7

[0113] The specific implementation of this comparative example is basically the same as that of Example 1, except that the drying process is carried out in a steam-heated drying room for 10 hours.

[0114] Comparative Example 8

[0115] The specific implementation of this comparative example is basically the same as that of Example 1, except that the drying process is carried out in a steam heating drying room for 10 hours and an electric heating drying room for 3 hours.

[0116] Comparative Example 9

[0117] The specific implementation of this comparative example is basically the same as that of Example 1, except that the honey refining temperature is 70°C.

[0118] The mass ratio of the medicinal powder to the refined honey is 1:0.9.

[0119] Comparative Example 10

[0120] The specific implementation of this comparative example is basically the same as that of Example 1, except that the honey refining temperature is 100°C.

[0121] The mass ratio of the medicinal powder to the refined honey is 1:1.3.

[0122] Comparative Example 11

[0123] The specific implementation of this comparative example is basically the same as that of Example 1, except that the honey refining temperature is 110°C.

[0124] The mass ratio of the medicinal powder to the refined honey is 1:1.5.

[0125] Performance Testing

[0126] 1. With reference to the test method in “Study on the Pharmacological Effect of Kuandong Zhisou Granules on Antitussive and Expectorant Effect”, Gao Huiqin and Wang Cunqin, Journal of Gansu University of Traditional Chinese Medicine, Vol. 26, No. 4, pp. 8-9, August 2009, a cough relieving experiment was conducted on the Ningsou Huatan Pills prepared in each embodiment and comparative example to observe the cough latency, the number of coughs within 3 minutes, and the tracheal phenol red secretion. The test results are shown in Table 1.

[0127] Table 1

[0128]

[0129] As can be seen from Table 1, the Ningsou Huatan Pills prepared in the present application can significantly prolong the cough latency period and reduce the number of coughs compared with the control example, and effectively increase the tracheal phenol red secretion, which proves that the Ningsou Huatan Pills prepared in the present application have obvious cough and phlegm-relieving effects.

[0130] 3. The appearance, moisture content (not exceeding 15%) and pill weight (qualified range 7.05-7.95 g) of the Ningsou Huatan pills prepared in each embodiment and comparative example were tested. The results are shown in Table 2.

[0131] 4. Yield Rate Test: Prepare 100 Ningsou Huatan Pills according to the methods of each Example and Comparative Example. Observe the appearance, moisture content, and pill weight of the prepared Ningsou Huatan Pills to see if they meet the acceptable standards. Acceptable standards include: appearance: uniform dark brown color, moisture content not exceeding 15%, and pill weight between 7.05-7.95g. Yield rate = qualified number / 100 * 100%.

[0132] Table 2

[0133] sample Appearance Moisture% Pill weight g Yield % Example 1 Dark brown and uniform color 12.3 7.5 93 Example 2 Dark brown and uniform color 11.7 7.41 90 Example 3 Dark brown and uniform color 12.4 7.51 92 Comparative Example 1 Dark brown but uneven color 14.5 7.34 89 Comparative Example 2 Dark brown and uniform color 11.2 7.01 60 Comparative Example 3 Dark brown and uniform color 12.9 8.01 62 Comparative Example 4 Dark brown and uniform color 12.7 8.12 67 Comparative Example 5 The color becomes darker and uneven 14.9 7.05 90 Comparative Example 6 Dark brown and uniform color 21.2 8.07 59 Comparative Example 7 Dark brown and uniform color 19.6 8.21 64 Comparative Example 8 Dark brown and uniform color 11.2 6.22 49 Comparative Example 9 Dark brown and uniform color 12.5 6.82 51 Comparative Example 10 Burnt black but uniform color 13.7 6.91 57 Comparative Example 11 Burnt black but uniform color 14.1 6.89 55

[0134] As can be seen from Table 2, the Ningsou Huatan Pills prepared in the present application have a uniform appearance and color, showing black-brown, and the yield rate is above 90%.

Claims

1. A Ningsou Huatan Pill, characterized in that: The raw materials for preparing the Ningsou Huatan Pills include basic medicinal materials and auxiliary medicinal materials; the basic medicinal herbs include Aster, Anemarrhena, Ophiopogon, Scutellaria, Lilium, Scrophularia, Angelica, Perilla, Schisandra, Rehmannia, Stemona, Tangerine Peel, Coltsfoot Flos, Pinellia, Asparagus, Radix Trichosanthis, Morus Alba, Fritillaria, Peucedanum, Inula, Platycodon, Licorice, Gardenia, and Bitter Apricot; the auxiliary medicinal materials include at least four of Ginkgo, Arisaema, Trichosanthes, Snow Lotus, Scutellaria, Momordica, Rhodiola, Azalea Leaf, Mulberry Leaf, Sterculia Sea, Loquat Leaf, and Artemisia selengensis.

2. The Ningsou Huatan Pill according to claim 1, characterized in that The mass ratio of the basic medicinal materials to the auxiliary medicinal materials is (14-16):

1.

3. The Ningsou Huatan Pill according to claim 1, characterized in that The auxiliary medicinal materials include ginkgo, arisaema, trichosanthes kirilowii and snow lotus, and the mass ratio of the ginkgo, arisaema, trichosanthes kirilowii and snow lotus is (1-2): (1-2): (1-2): (1-2).

4. The Ningsou Huatan Pill according to claim 1, characterized in that The auxiliary medicinal materials include radix scutellariae, fructus momordicae, rhodiola rosea and azalea leaves, and the mass ratio of radix scutellariae, fructus momordicae, rhodiola rosea and azalea leaves is (1-2): (1-2): (1-2): (1-2).

5. The Ningsou Huatan Pill according to claim 1, characterized in that The auxiliary medicinal materials include mulberry leaves, puffed sea, loquat leaves and oxtail wormwood, and the mass ratio of the mulberry leaves, puffed sea, loquat leaves and oxtail wormwood is (1-2): (1-2): (1-2): (1-2).

6. A method for preparing the Ningsou Huatan Pills according to any one of claims 1 to 5, characterized in that: At least the following steps are included: The raw materials are pre-treated, crushed, sieved and mixed to form powder; The medicinal powder is mixed with refined honey to prepare pills, thereby obtaining the Ningsou Huatan pills.

7. The method for preparing Ningsou Huatan Pills according to claim 6, characterized in that: The pretreatment includes washing and drying the basic medicinal materials and the auxiliary medicinal materials respectively; in the drying process, the drying temperature of angelica does not exceed 60°C, and the drying temperature of other preparation raw materials does not exceed 80°C.

8. The method for preparing Ningsou Huatan Pills according to claim 7, characterized in that: The drying process is to sequentially pass through an electric heating drying room and a steam heating drying room for drying.

9. The method for preparing Ningsou Huatan Pills according to claim 6, characterized in that: The refined honey is made from honey at a temperature of 80-90°C.

10. The preparation method of Ningsou Huatan Pills according to claim 9, characterized in that: The mass ratio of the medicinal powder to the refined honey is 1:(1-1.2).

Images