Traditional Chinese medicine preparation for improving postoperative gastrointestinal function and lung function and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine, and discloses a traditional Chinese medicine preparation for improving postoperative gastrointestinal function and lung function, and the traditional Chinese medicine preparation at least comprises the following raw materials: 10-15 parts of almond, 15-20 parts of gypsum, 5-10 parts of rheum officinale, 5-10 parts of immature bitter orange, 5-10 parts of mangnolia officinalis and 3-5 parts of liquorice. The preparation method comprises the following steps: adding the cleaned and aired almonds, rheum officinale, fructus aurantii immaturus, mangnolia officinalis and liquorice into gypsum according to the mass part ratio to obtain a mixed medicinal material; adding the mixed medicinal materials into water, decocting and filtering to obtain filtrate; concentrating the filtrate into extract with the relative density of 1.2-1.3, and performing spray drying to obtain dry extract powder; and mixing the dry paste with auxiliary materials to prepare the traditional Chinese medicine preparation. The traditional Chinese medicine composition can relieve postoperative inflammatory response of patients, enhance immune function, improve lung and intestine functions of colorectal cancer patients, regulate gastrointestinal flora of the patients, regulate dysfunction of internal organs in the perioperative period and promote postoperative rehabilitation.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and in particular to a traditional Chinese medicine preparation for improving postoperative gastrointestinal function and lung function and a preparation method thereof. Background Art

[0002] The primary treatment strategy for colorectal cancer is surgical resection, which, while effective, remains a significant challenge. Patients often experience impaired pulmonary and gastrointestinal function due to factors such as anesthesia and surgical trauma. Pulmonary infection and intestinal obstruction are common complications after colorectal cancer surgery, with incidence rates ranging from 1.3% to 18.6% and 2.94% to 44.12%, respectively. These complications can impact the patient's recovery process and affect postoperative recovery. Therefore, ensuring the safety of colorectal cancer patients and effectively accelerating their recovery has become a hot topic of ongoing concern and research within the medical community, both domestically and internationally.

[0003] To alleviate postoperative complications, fast-track surgery is an interdisciplinary collaborative model designed to accelerate postoperative recovery through comprehensive, multifaceted measures. These have proven to be effective in gastrointestinal surgery, including emotional regulation, dietary care, massage, and acupuncture. However, these approaches are slow to take effect, necessitating the need for other approaches that can effectively and specifically intervene in the recovery of gastrointestinal and pulmonary function. Summary of the Invention

[0004] The purpose of the present invention is to provide a traditional Chinese medicine preparation for improving postoperative gastrointestinal function and lung function and a preparation method thereof, so as to solve the technical problem of accelerating the postoperative recovery of colorectal cancer patients in the prior art.

[0005] In order to solve the above technical problems, the present invention specifically provides the following technical solutions:

[0006] The present invention provides a traditional Chinese medicine preparation for improving postoperative gastrointestinal function and lung function. The raw materials of the traditional Chinese medicine preparation include at least 10-15 parts of apricot kernel, 15-20 parts of gypsum, 5-10 parts of rhubarb, 5-10 parts of immature bitter orange, 5-10 parts of magnolia bark and 3-5 parts of liquorice in parts by weight.

[0007] The present invention also provides a method for preparing a traditional Chinese medicine preparation for improving postoperative gastrointestinal function and lung function, comprising the following steps:

[0008] Adding washed and dried almonds, rhubarb, immature bitter orange, magnolia bark, and liquorice to gypsum according to a mass ratio to obtain a mixed medicinal material;

[0009] adding the mixed medicinal materials into water, boiling, filtering, and obtaining a filtrate;

[0010] The filtrate is concentrated to an extract with a relative density of 1.2-1.3, and spray-dried to obtain a dry extract powder;

[0011] The dry paste is mixed with auxiliary materials to prepare a traditional Chinese medicine preparation.

[0012] As a preferred embodiment of the present invention, the mass ratio of the mixed medicinal materials to the water is 1:10.

[0013] As a preferred embodiment of the present invention, the decocting time is 2 hours.

[0014] As a preferred embodiment of the present invention, the excipient is a pharmaceutically acceptable excipient.

[0015] As a preferred embodiment of the present invention, the dosage form of the traditional Chinese medicine preparation is any one of granules, capsules or tablets.

[0016] Compared with the prior art, the present invention has the following beneficial effects:

[0017] The present invention adopts a traditional Chinese medicine preparation prepared from apricot kernel, gypsum, rhubarb, immature bitter orange, magnolia bark and liquorice, which can be taken before surgery to reduce the patient's postoperative inflammatory response, enhance immune function, improve the lung and intestinal function of patients with colorectal cancer, regulate the patient's gastrointestinal flora, adjust the perioperative organ dysfunction, and promote postoperative recovery;

[0018] During the preparation process of the traditional Chinese medicine preparation of the present invention, the extract is concentrated to a relative density of 1.2-1.3, so that the extract can be dried quickly in the spray drying process to the greatest extent possible. The dry extract powder is mixed with other auxiliary materials to form a homogeneous medicine, which can realize the large-scale production of the medicine. Patients do not need to decoct the medicine in the hospital, the medicine is easy to use, and the dosage is easy to control when taking it. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] To more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for the embodiments or the description of the prior art. Obviously, the drawings described below are merely exemplary, and those skilled in the art can derive other implementation drawings based on the provided drawings without inventive effort.

[0020] Figure 1 The present invention provides a flow chart of a method for preparing a traditional Chinese medicine preparation for improving postoperative gastrointestinal function and lung function. DETAILED DESCRIPTION

[0021] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0022] The present invention provides a traditional Chinese medicine preparation for improving postoperative gastrointestinal function and lung function. The raw materials of the traditional Chinese medicine preparation include at least 10-15 parts of apricot kernel, 15-20 parts of gypsum, 5-10 parts of rhubarb, 5-10 parts of immature bitter orange, 5-10 parts of magnolia bark and 3-5 parts of liquorice in parts by weight.

[0023] This traditional Chinese medicine preparation has the effects of promoting lung function, clearing away heat and resolving phlegm. It is suitable for symptoms such as lung heat and phlegm accumulation, dry intestines and constipation. By regulating the functions of the lungs and large intestine, it can improve pulmonary and gastrointestinal function in postoperative patients. Rhubarb clears gastrointestinal stagnation and promotes lung function; gypsum has a pungent and cold nature, clearing away excess heat; and almonds have a pungent and bitter nature, promoting lung qi. Combined with Citrus aurantium and Magnolia officinalis, it promotes intestinal motility, relieves abdominal distension, alleviates chest tightness and phlegm, and excretes excess water.

[0024] For patients undergoing colorectal cancer resection, postoperative complications often involve the lungs and large intestine, as the cancer is located in the large intestine. From the perspective of meridians, the large intestine and lungs have an exterior-interior relationship. Physiologically, when lung qi descends, the large intestine's conduction function is normal; pathologically, when the large intestine's internal qi is blocked, the lung qi's descending function fails. Taking postoperative pneumonia as an example, it falls under the category of "lung heat disease" in Traditional Chinese Medicine, and the syndrome differentiation is often based on phlegm-heat obstructing the lungs. This indicates that colorectal cancer patients, with long-term internal qi obstruction, have lurking pathogens in their lungs, and the disease is caused by a weakened vital energy after surgery. At the same time, the "lung-gut axis" theory in modern medicine also confirms the mutual influence between the immune response of the respiratory tract and the digestive tract flora and its immune response. Gastrointestinal dysfunction can lead to worsening lung function and increase the incidence of complications such as postoperative pneumonia and intestinal obstruction.

[0025] The Chinese medicine preparation disclosed in the present invention improves lung function and gastrointestinal function by simultaneously intervening on the lungs and large intestine. The Chinese medicine preparation can be taken before surgery. When used before surgery, it can intervene in the location of the lesion when the patient's vital energy is still sufficient and the disease has not yet developed, achieving the purpose of "eliminating the evil and restoring the vital energy", and promoting the patient's rapid recovery after surgery. Pharmacological studies have confirmed that rhubarb can promote gastrointestinal motility, accelerate toxin excretion, inhibit bacterial reproduction, accelerate gastrointestinal mucosal blood circulation and damage repair; Zhishi and Magnolia officinalis promote intestinal motility, relieve abdominal distension, improve chest tightness and sputum, and expel excess water from the body; Gypsum can inhibit neural stress and has antipyretic, anti-inflammatory, antispasmodic and immune-enhancing effects, thereby accelerating the recovery of gastrointestinal function and shortening the patient's hospital stay.

[0026] See Figure 1 As shown, the present invention also provides a method for preparing the above-mentioned traditional Chinese medicine preparation for improving postoperative gastrointestinal function and lung function, comprising the following steps:

[0027] (1) Raw material processing: according to the amount, wash 10-15 parts of apricot kernel, 15-20 parts of gypsum, 5-10 parts of rhubarb, 5-10 parts of immature bitter orange, 5-10 parts of magnolia bark, and 3-5 parts of liquorice respectively, dry them, and mix them to prepare a mixed medicinal material;

[0028] (2) Decoction extraction: add 10 times the mass of water to the mixed medicinal materials according to the mass ratio, decoct for 2 hours, filter, and obtain the filtrate;

[0029] (3) Concentration and drying: The filtrate is concentrated to an extract with a relative density of 1.2-1.3, and spray-dried to obtain a dry paste powder.

[0030] (4) Preparation molding: Mix the dry paste powder with appropriate amount of auxiliary materials to make granules, capsules or tablets.

[0031] The above-mentioned almonds and gypsum can clear the lungs and heat, relieve lung heat and phlegm, and improve lung ventilation function. Rhubarb, Citrus aurantium, and Magnolia officinalis can clear the bowels and relieve heat, promote gastrointestinal motility, and relieve postoperative intestinal paralysis. Licorice harmonizes all the medicines and reduces the irritation of the drugs to the gastrointestinal tract.

[0032] Generally, patients can directly take the decoction filtrate of the medicine. This Chinese medicine preparation is concentrated to a relative density of 1.2-1.3, so that the extract can be dried quickly in the spray drying process to the greatest extent possible. The dry paste powder is mixed with other excipients to form a homogeneous medicine, which can realize the large-scale production of the medicine. Patients do not need to decoct the medicine in the hospital. It is easy to use and the dosage is easy to control when taking it.

[0033] The excipients can be any pharmaceutically acceptable excipient, such as starch.

[0034] The following examples are provided to illustrate the functions of the Chinese medicine preparation:

[0035] Example 1:

[0036] (1) Select 12 parts of almonds, 18 parts of gypsum, 8 parts of rhubarb, 8 parts of immature bitter orange, 8 parts of magnolia bark, and 4 parts of liquorice, wash them, dry them, and mix them together;

[0037] (2) Add 10 times the amount of water, boil for 2 hours, and filter to obtain the filtrate;

[0038] (3) Concentrating the filtrate to an extract with a relative density of 1.2, and spray drying it in a spray dryer to obtain a dry extract powder;

[0039] (4) Mix the dry paste powder with an appropriate amount of starch slurry to make granules.

[0040] Example 2

[0041] Select 15 parts of apricot kernel, 20 parts of gypsum, 10 parts of rhubarb, 10 parts of immature bitter orange, 10 parts of magnolia bark and 5 parts of liquorice, and prepare capsules according to the above method.

[0042] Example 1 was selected as the following prospective randomized controlled study method to investigate the effect of preoperative application of Xuanfei Chengqi Decoction under the guidance of CMERA on the recovery of patients after colorectal cancer surgery.

[0043] 1. Patient selection: One hundred patients who underwent colorectal cancer surgery at Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, were randomly divided into two groups, each containing 50 patients (in accordance with medical ethics requirements and approved by the Medical Ethics Committee of Beijing Hospital of Traditional Chinese Medicine, Capital Medical University).

[0044] 2. Standard judgment of patient recovery: Western medicine diagnostic standards for colorectal cancer patients may have the following clinical symptoms: changes in stool shape and bowel habits, such as thinner stools or stools with mucus; accompanied by abdominal pain, abdominal discomfort, chronic diarrhea, abdominal masses and chronic constipation, and sometimes signs of intestinal obstruction; systemic symptoms may include fever, weight loss and fatigue; laboratory tests may reveal anemia, hematuria, stool examination may reveal red blood cells and pus cells, and fecal occult blood test may be positive; final diagnosis requires B-ultrasound, CT or MRI examination.

[0045] Diagnostic criteria in Traditional Chinese Medicine: The main clinical manifestations include abdominal distension and pain, mental fatigue, loss of appetite, and a yellow complexion; secondary symptoms include a feeling of tenesmus, a feeling of heaviness and heat in the anus, sticky and foul-smelling stools, or stools with mucus and blood; the tongue appears enlarged, with a greasy white or slightly yellowish coating, and the pulse is slow or slippery.

[0046] Inclusion criteria included: ① meeting the aforementioned diagnostic criteria for both traditional Chinese medicine and Western medicine; ② surgery performed by the same surgeon and their fixed surgical team, with a clear pathological diagnosis; ③ no prior prior treatment; ④ clear consciousness, normal communication skills, and willingness and ability to adhere to the study protocol; and ⑤ expected survival time ≥ 6 months. Exclusion criteria included: ① patients with severe organ dysfunction, such as heart, liver, or kidney; ② patients with a history of allergic reactions to the study drugs; ③ patients with severe, uncontrolled, recurrent infections; ④ patients receiving other adjunctive Chinese medicine treatments after surgery; and ⑤ patients with poor compliance and failure to follow the prescribed treatment protocol.

[0047] 3. Treatment methods:

[0048] (1) First, during the perioperative period, both groups of patients received standard treatment measures, and no other traditional Chinese medicine therapies to promote gastrointestinal function recovery were used.

[0049] Perioperative management for CMERAS is as follows: ① Emotional regulation: For patients experiencing low mood or depression, humorous stories or crosstalk can be used to stimulate joy and alleviate anxiety. This "joy overcomes sorrow" approach can help patients release liver qi and improve their emotional state. ② Traditional Chinese Medicine dietary care: In the initial postoperative period, patients should consume light, easily digestible liquid foods such as porridge, soy milk, and vegetable soup, avoiding greasy, spicy, and high-fat foods. As intestinal function recovers, the nutritional content of foods such as lean meat, eggs, and soy products can be gradually increased. A balanced blend of sour, sweet, bitter, spicy, and salty flavors can be achieved based on the patient's taste and constitution, avoiding partial cravings. ③ Symptom prevention and relief: Acupoint massage is recommended to promote bowel movements. Selected acupoints include Dachangshu, Tianshu, and Zusanli, which are closely related to digestive system function. Massage 15 to 20 times daily. Massaging these acupoints can regulate intestinal function and alleviate digestive problems such as constipation. ④ Acupuncture: Selected primary acupoints include the large intestine, lungs, stomach, spleen, and kidneys. These acupoints are closely related to the body's excretion function and overall health. Based on the patient's specific symptoms and TCM syndrome differentiation, appropriate acupoints are selected. For patients with hyperactivity of liver yang, acupoints such as the liver, gallbladder, and Shenmen are added; for those with insomnia, Shenmen and sympathetic points are selected. Acupuncture treatment should be performed once a day. ⑤ Traditional Chinese Medicine Foot Soak: Based on the patient's symptoms and syndrome differentiation, appropriate Chinese medicinal materials are selected. Add the Chinese medicinal powder to boiling water and stir evenly. When the water is at an appropriate temperature, soak for 20-30 minutes once a day to help relieve tension and discomfort and promote blood circulation.

[0050] (2) Control group: Patients were given an oral placebo. The placebo composition was: 2% caramel pigment, 0.35% lemon yellow pigment, 0.04% sunset yellow pigment, 0.04% sugar octaacetate, 0.03% tangerine peel essence and maltodextrin, calculated on a total solid basis. Caramel pigment and other pigments and sugar octaacetate were first dissolved in water and then sprayed to obtain a spray-dried powder. Tangerine peel essence was then encapsulated with β-cyclodextrin and added to the spray-dried powder to form granules. The placebo granules were similar in color to the test drug granules, as well as in the color, bitterness, and odor of the decoction after dissolving in the corresponding proportion.

[0051] (3) Drug-administered group: Patients were given the Chinese medicine preparation prepared in Example 1, one dose per day, warm, for 7 days.

[0052] 4. Comparison of characteristics: The time required for postoperative gastrointestinal function recovery, TCM symptom scores, immune factors, lung function, quality of life, incidence of complications, and TCM symptom efficacy evaluation were observed between the two groups. SPSS 23.0 statistical software was used for data processing and analysis.

[0053] For measurement data, first ensure that it meets the prerequisites of normal distribution and homogeneity of variance, and then use mean ± standard deviation The central tendency and dispersion of these data were described in the form of . When comparing between groups, the independent sample t-test was used to assess whether the mean difference between the two groups was statistically significant. For intra-group comparisons, the paired sample t-test was used to explore the mean difference under different conditions within the same group. For count data, the rate (%) was used to describe the proportion of each category in the population. When comparing the proportion differences between the two groups, the χ2 test was used to assess whether these differences were statistically significant. Throughout the statistical analysis process, the two-sided test principle was strictly followed, and the P value was set at 0.05 as the threshold for judging whether the difference was statistically significant. When the P value was less than 0.05, the observed difference was considered not to be due to chance factors but to be a real statistical difference.

[0054] 5. Research Results

[0055] (1) Comparison of baseline data

[0056] See Table 1:

[0057] Table 1

[0058]

[0059] Table 1 is a comparison chart of the baseline data of the two groups of patients undergoing colon cancer surgery. It can be seen from the figure that the baseline data of the two groups are balanced and comparable (p>0.05), and there is no significant difference between the two groups of patients before taking the above-mentioned treatment measures.

[0060] (2) Comparison of time required for postoperative gastrointestinal function recovery

[0061] See Table 2:

[0062] Table 2

[0063]

[0064] Table 2 is a comparison chart of the time taken for gastrointestinal function to recover after surgery in the two groups of patients. The chart shows that the time taken for gastrointestinal function to recover after surgery in the medication group was shorter than that in the control group (p<0.01), and the decrease in the medication group was more obvious.

[0065] (The time to first flatus after surgery and the time to recovery of enteral nutrition are important indicators of gastrointestinal function recovery and are of great significance to the patient's recovery and the occurrence of complications)

[0066] (3) Comparison of TCM symptom scores

[0067] The results are shown in Table 3:

[0068] Table 3

[0069]

[0070] Continued table

[0071]

[0072] Table 3 compares the TCM symptom scores of the two groups of colorectal cancer patients before and after surgery. As can be seen from the figure, preoperatively, the TCM symptom scores of the two groups were similar (p>0.05). Seven days after surgery, the TCM symptom scores of both groups decreased (p<0.01), with the decrease being more significant in the drug-treated group (p<0.01).

[0073] (4) Comparison of serum immune factor levels before and after surgery

[0074] The results are shown in Table 4:

[0075] Table 4

[0076]

[0077] Table 4 compares the levels of serum immune factors before and after surgery in the two groups. As shown in the middle figure, preoperatively, there was no difference in serum GM-CSF, NLRP3, and TLR4 levels between the two groups (P>0.05). Seven days after surgery, serum GM-CSF levels increased in both groups compared with preoperative levels (P<0.01), with the drug-treated group showing a higher level (P<0.01). Seven days after surgery, serum NLRP3 and TLR4 levels decreased in both groups compared with preoperative levels (P<0.05), with the drug-treated group showing a lower level (P<0.01).

[0078] (5) Comparison of lung function before and after surgery

[0079] The results are shown in Table 5:

[0080] Table 5

[0081]

[0082] Table 5 shows the statistical comparison of lung function before and after surgery in the two groups. Before surgery, there was no difference in lung function between the two groups (P>0.05). Seven days after surgery, lung function in both groups increased compared with preoperative levels (P<0.01), and the drug group had a higher level (P<0.05).

[0083] (6) Comparison of EORCTQLQ-C30 scores before and after surgery

[0084] The results are shown in Table 6:

[0085] Table 6

[0086]

[0087] Table 6 shows the EORCTQLQ-C30 scores for the two groups before and after surgery. As shown in the figure, there was no difference in EORCTQLQ-C30 scores between the two groups before surgery (P>0.05). Seven days after surgery, EORCTQLQ-C30 scores increased in both groups compared to preoperative scores (P<0.01), with the score in the medication group being significantly higher (P<0.01).

[0088] (7) Comparison of complications

[0089] The results are shown in Table 7:

[0090] Table 7

[0091]

[0092] Table 7 is a statistical chart of the incidence of complications in the two groups of patients. It can be seen from the figure that within 4 weeks after surgery, 1 case of lower gastrointestinal paralysis and 1 case of incision infection occurred in the observation group, with an adverse reaction rate of 4.00% (2 / 50); 1 case of lung infection, 2 cases of incision infection, 2 cases of intestinal obstruction, 2 cases of lower gastrointestinal paralysis, and 1 case of gastrointestinal bleeding occurred in the control group, with an adverse reaction rate of 16.00% (8 / 50).

[0093] The incidence of complications in the drug-treated group was lower than that in the control group (χ2=4.000, P=0.040).

[0094] Based on the above research results, CMERAS combines the advantages of TCM's syndrome differentiation and treatment with modern surgical techniques. By applying a series of optimization measures based on TCM theory and practice during the perioperative period, it aims to reduce the perioperative stress response of surgical patients, improve the body's immunity, and thus promote postoperative recovery. The proposal and application of CMERAS, combined with this embodiment, can further enhance the therapeutic effect of CMERAS, providing a new clinical practice path for the integration of traditional Chinese and Western medicine.

[0095] Both animal experiments and clinical studies have confirmed that this traditional Chinese medicine preparation can enhance intestinal barrier function and promote lung barrier repair. The total effective rate in the treatment group was higher than that in the control group [96.00% (48 / 50) vs. 84.00% (42 / 50)] (P < 0.05), and gastrointestinal function recovery time was shorter than that in the control group (P < 0.05). The treatment group also showed significantly better improvements in Traditional Chinese Medicine symptom scores, serum immune factors, lung function, and EORCT QLQ-C30 scores than the control group (P < 0.05).

[0096] At the same time, 7 days after surgery, the serum GM-CSF level in the observation group was higher than that in the control group, while the serum NLRP3 and TLR4 levels were lower than those in the control group (P < 0.05). This shows that the Chinese medicine preparation provided by the present invention can significantly inhibit inflammatory responses and enhance the body's immunity when applied to colorectal cancer patients before surgery. In addition, the incidence of postoperative complications in the treatment group was lower than that in the control group, indicating that this Chinese medicine preparation can reduce the risk of postoperative complications in colorectal cancer patients.

[0097] It can be seen that the preoperative application of this traditional Chinese medicine preparation can significantly alleviate the postoperative clinical symptoms of patients with colorectal cancer, improve immune function and lung function, promote gastrointestinal function recovery, and improve clinical efficacy.

[0098] Anti-inflammatory principle description: This Chinese medicine preparation regulates the expression of patients' immune factors

[0099] GM-CSF plays an important role in regulating inflammatory responses. It can promote the activation and function of immune cells in inflammatory sites, enhance the body's immune surveillance ability by regulating the function of dendritic cells, and promote the activation of cytotoxic T lymphocytes, thereby enhancing the body's ability to kill tumor cells.

[0100] NLRP3 and TLR4 are two key components of the body's innate immune system. They play a central role in identifying and responding to pathogen-associated molecular patterns through pattern recognition receptors. NLRP3 is a regulatory protein for inflammasome assembly that responds to a variety of pathogens and intracellular danger signals. When activated, NLRP3 induces inflammasome assembly, thereby initiating inflammatory responses and cell apoptosis. TLR4 is a receptor that recognizes lipopolysaccharide. This recognition can initiate a series of signaling pathways, leading to the production of inflammatory factors such as tumor necrosis factor α and interleukin 6, playing an important role in regulating inflammatory responses and recruiting immune cells.

[0101] In the medicament provided by the present invention, raw rhubarb has the effects of reducing inflammatory reactions and enhancing immune function, and these effects may be achieved through the following mechanisms: 1. Inhibiting inflammatory reactions: The active ingredients in raw rhubarb may have anti-inflammatory effects, by inhibiting the synthesis and release of inflammatory mediators, thereby reducing inflammatory reactions; 2. Promoting the secretion of immune substances: Raw rhubarb may stimulate intestinal mucosal epithelial cells to secrete a variety of immune substances, such as antibodies and cytokines, which can enhance the body's immune defense capabilities and fight against the invasion of pathogens; 3. Regulating intestinal flora: Raw rhubarb may indirectly promote the improvement of immune function by regulating the balance of intestinal flora and enhancing the growth of beneficial flora.

[0102] There was no statistically significant difference in the incidence of complications and adverse reactions between the two groups after treatment, indicating that the use of this Chinese medicine preparation before surgery did not increase the incidence of adverse reactions and complications and was highly safe.

[0103] In summary, the preoperative application of the Chinese medicine preparation of this embodiment under the guidance of CMERAS theory can simultaneously improve the lung and intestinal function of patients with colorectal cancer, adjust the perioperative organ dysfunction, and promote postoperative recovery.

[0104] The above embodiments are merely exemplary embodiments of the present application and are not intended to limit the scope of the present application. The scope of protection of the present application is defined by the claims. Those skilled in the art may make various modifications or equivalent substitutions to the present application within the essence and scope of protection of the present application, and such modifications or equivalent substitutions shall also be deemed to fall within the scope of protection of the present application.

Claims

1. A Chinese medicine preparation for improving postoperative gastrointestinal function and lung function, characterized in that: Calculated by weight, the formula raw materials of the traditional Chinese medicine preparation include at least: 10-15 parts of apricot kernel, 15-20 parts of gypsum, 5-10 parts of rhubarb, 5-10 parts of immature bitter orange, 5-10 parts of magnolia bark, and 3-5 parts of liquorice.

2. A method for preparing a traditional Chinese medicine preparation for improving postoperative gastrointestinal function and pulmonary function according to claim 1, characterized in that: The steps include: Adding washed and dried almonds, rhubarb, immature bitter orange, magnolia bark, and liquorice to gypsum according to a mass ratio to obtain a mixed medicinal material; adding the mixed medicinal materials into water, boiling, filtering, and obtaining a filtrate; The filtrate is concentrated to an extract with a relative density of 1.2-1.3, and spray-dried to obtain a dry extract powder; The dry paste is mixed with auxiliary materials to prepare a traditional Chinese medicine preparation.

3. The method for preparing a traditional Chinese medicine preparation for improving postoperative gastrointestinal function and pulmonary function according to claim 2, characterized in that: The mass ratio of the mixed medicinal materials to the water is 1:

10.

4. The method for preparing a traditional Chinese medicine preparation for improving postoperative gastrointestinal function and pulmonary function according to claim 2, characterized in that: The decoction time is 2 hours.

5. The method for preparing a traditional Chinese medicine preparation for improving postoperative gastrointestinal function and pulmonary function according to claim 2, characterized in that: The excipients are pharmaceutically acceptable excipients.

6. The method for preparing a traditional Chinese medicine preparation for improving postoperative gastrointestinal function and pulmonary function according to claim 2, characterized in that: The dosage form of the traditional Chinese medicine preparation is any one of granules, capsules or tablets.

Images