Concentrated foot bath liquid capable of clearing damp and dispelling cold and preparation method of concentrated foot bath liquid

Abstract

The invention discloses concentrated foot bath liquid capable of clearing damp and dispelling cold and a preparation method, and belongs to the technical field of pharmaceutical preparations. The concentrated foot bath liquid capable of clearing damp and dispelling cold comprises the following raw material components in parts by weight: 30-50 parts of folium artemisiae argyi powder, 10-20 parts of safflower powder, 15-25 parts of dried ginger powder, 15-25 parts of cassia twig powder, 20-30 parts of garden balsam stem powder, 20-30 parts of papaya powder and 5-15 parts of licorice powder. The concentrated foot bath liquid for clearing damp and dispelling cold is prepared from multiple traditional Chinese medicinal materials, overcomes the defects that an existing foot bath product is single in component and simple and crude in preparation process, and compared with traditional foot bath liquid, the dissolution rate of effective components is greatly increased by 30%-50%, the drug effects of all the medicinal materials are fully released, the synergistic interaction effect is achieved, and meanwhile the effect of clearing damp and dispelling cold is achieved. Advanced processes such as superfine grinding, supercritical extraction and irradiation sterilization are adopted, the extraction and utilization rate of effective components is remarkably improved, the optimized dosage form is designed to be a bagged concentrated type, one large package contains seven small packages, each small package contains 40 m < 1 >, pollution and waste caused by repeated opening of a traditional large package are avoided, carrying is convenient, and the health preserving requirements of home and travel are met.

Description

Technical Field

[0001] The present invention relates to the technical field of pharmaceutical preparations, and in particular to a dampness-dispelling and cold-dispelling concentrated foot-soaking liquid and a preparation method thereof. Background Art

[0002] With the acceleration of the pace of modern life, people are facing increasing pressure, and physical health problems are becoming increasingly prominent. Among them, the invasion of dampness and cold has become one of the important factors affecting people's health. Dampness and cold can easily cause problems such as joint pain, limb numbness, indigestion, decreased immunity, etc., which seriously affect people's quality of life and work efficiency.

[0003] In traditional Chinese medicine theory, the feet are regarded as the "second heart" of the human body and are closely connected with the meridians and internal organs of the whole body. As a simple and easy way to maintain health, foot soaking can effectively promote blood circulation, accelerate metabolism, dispel dampness and cold, dredge meridians, and harmonize internal organs through the thermal stimulation of warm water and the pharmacological effects of medicinal materials. It helps to improve and prevent various diseases.

[0004] However, there are some shortcomings in the foot soaking products currently on the market. On the one hand, the ingredients of many foot soaking products are relatively simple, containing only a few common Chinese medicinal materials, which can hardly meet people's demand for efficient and multi-functional health care products. On the other hand, the preparation process of some foot soaking products is relatively simple. For example, only simple medicinal material decoction or rough processing methods are used, resulting in low extraction and utilization rates of effective ingredients, affecting the efficacy of foot soaking. In addition, the dosage form design of some foot soaking products is not reasonable. For example, traditional foot soaking liquids are mostly in large-capacity bottles or bulk form, which are not convenient to use and carry, and easily cause waste or pollution. Summary of the Invention

[0005] The main purpose of the present invention is to provide a method for preparing a concentrated foot-soaking liquid for dispelling dampness and cold, so as to solve the problems of existing foot-soaking products such as single ingredients, simple preparation process and unreasonable dosage form design.

[0006] To achieve the above object, the technical solution adopted by the present invention is:

[0007] A concentrated foot-soaking liquid for dispelling dampness and dispelling cold comprises the following raw material components in parts by weight: 30-50 parts of mugwort leaf powder, 10-20 parts of safflower pollen, 15-25 parts of dried ginger powder, 15-25 parts of cassia twig powder, 20-30 parts of radix polygoni lobatae powder, 20-30 parts of papaya powder, and 5-15 parts of liquorice powder.

[0008] Preferably, the specific weight parts of the raw material components are: 40 parts of mugwort powder, 15 parts of safflower powder, 20 parts of dried ginger powder, 20 parts of cinnamon twig powder, 25 parts of radix polygoni lobata powder, 25 parts of papaya powder, and 10 parts of licorice powder.

[0009] The present invention also discloses a preparation method of a concentrated foot soaking liquid for dispelling dampness and cold, comprising the following steps:

[0010] S1. Raw material pretreatment: Weigh all raw materials according to the formula ratio, dry them until the moisture content is less than 10%, and then coarsely chop them into small pieces with a diameter of 5-10 mm;

[0011] S2. Ultrafine grinding:

[0012] S21, coarse crushing: the pre-treated medicinal materials are put into a coarse crusher and crushed into particles with a particle size of 1-3 mm at a speed of 800-1200 r / min;

[0013] S22, fine grinding: the coarsely crushed particles are screened through a vibrating screen and then put into a fine grinder, and ground into 200-300 mesh powder at a speed of 2000-3000 r / min;

[0014] S23, ultrafine grinding: the finely ground powder is crushed by using an airflow ultrafine grinder at a pressure of 0.5-0.8 MPa and an airflow velocity of 300-500 m / s, the particle size is controlled to be less than 5-10 μm, and the grinding temperature is controlled at 20-30°C;

[0015] S3, mixing and stirring: put the ultrafinely crushed raw material powders into a high-speed mixer in proportion, and stir at a speed of 600-1000 r / min for not less than 30 minutes;

[0016] S4, extraction and concentration: the mixed powder is put into a supercritical extraction device, with carbon dioxide as the extraction agent, and extracted at a pressure of 20-30 MPa and a temperature of 40-50°C for 2-3 hours to separate and obtain a concentrated solution;

[0017] S5, filtering and removing impurities: the concentrate is filtered under reduced pressure through 100 mesh, 200 mesh and 300 mesh filters in sequence;

[0018] S6. Irradiation sterilization: The filtered concentrate is sterilized by γ-ray irradiation at a dose of 5-10 kGy;

[0019] S7. Finished product packaging: Aseptically package the sterilized concentrated foot bath liquid according to specifications.

[0020] Preferably, in step S1, the drying process adopts hot air circulation drying, the drying temperature is 40-60° C., and the drying time is 2-4 hours.

[0021] Preferably, in step S23, cooling water is introduced into the grinding chamber of the airflow ultrafine grinder to reduce the temperature so as to control the grinding temperature.

[0022] Preferably, in step S4, after supercritical extraction, the concentrated solution is separated by reducing the temperature to 5-15° C. and the pressure to 5-10 MPa.

[0023] Preferably, in step S5, the clarity of the concentrated liquid after filtration reaches above 95%.

[0024] Preferably, in step S7, the packaging material is in bag form, one packaging unit contains 7 independent packaging units, and the solution volume of each independent packaging unit is 40 ml.

[0025] 1. The dampness-relieving and cold-dispelling concentrated foot-soaking liquid of the present invention adopts a scientific ratio of multiple Chinese medicinal materials, which changes the shortcomings of the existing foot-soaking products with a single ingredient and a simple preparation process. Experimental data show that compared with the traditional simple decocted foot-soaking liquid, the dissolution rate of the effective ingredients is greatly increased by 30%-50%, fully releasing the medicinal effects of each medicinal material and exerting a synergistic effect. At the same time, advanced processes such as ultrafine grinding, supercritical extraction and irradiation sterilization are adopted to significantly improve the extraction and utilization rate of the effective ingredients, and the dosage form is optimized to be a bagged concentrated type. One large package contains 7 small packages, each small package is 40ml, which accurately matches the single foot-soaking dosage, avoids the pollution and waste caused by repeated opening of traditional large packages, is easy to carry, meets the health needs at home and travel, and effectively solves the shortcomings of the existing foot-soaking product ingredients, processes and dosage forms.

[0026] 2. The foot-soaking liquid preparation method of the present invention accurately controls the parameters of each step, from the drying temperature and time of raw material pretreatment, to the particle size and temperature of ultrafine grinding, and then to the pressure, temperature and time of extraction and concentration, etc., to ensure that each step extracts and retains the effective ingredients of the medicinal materials to the greatest extent. Experiments show that the foot-soaking liquid prepared by this method has a high dissolution rate of effective ingredients and long-lasting and stable medicinal effect. Compared with foot-soaking liquids prepared by other preparation processes, it can more efficiently exert the effects of removing dampness and cold, promoting blood circulation, etc., thereby enhancing the market competitiveness of the product.

[0027] 3. The present invention adopts irradiation sterilization instead of chemical preservation means, and uses the gamma rays generated by the cobalt source to sterilize the concentrated foot bath liquid, effectively killing various microorganisms such as bacteria, molds, viruses, etc. in the product, so that the microbial limit meets the prescribed standards, and the shelf life of the product can be extended to 18-24 months. Compared with the shelf life of 6-12 months of traditional chemically preserved and sterilized foot bath liquid, the present invention significantly extends the shelf life of the product, effectively ensures the safety and stability of use, and solves the problems of potential safety hazards and short shelf life of existing foot bath products due to the use of chemical preservation. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 Prepare a flow chart for the present invention portion;

[0029] Figure 2 A flow chart was prepared for another portion of the invention. DETAILED DESCRIPTION

[0030] In order to make the technical means, creative features, objectives and effects achieved by the present invention easier to understand, the present invention is further described below in conjunction with specific implementation methods.

[0031] See also Figure 1 and Figure 2 As shown, a concentrated foot soaking liquid for dispelling dampness and cold comprises the following raw material components in parts by weight: 30-50 parts of mugwort powder, 10-20 parts of safflower pollen, 15-25 parts of dried ginger powder, 15-25 parts of cassia twig powder, 20-30 parts of radix polygoni lobata powder, 20-30 parts of papaya powder, and 5-15 parts of licorice powder.

[0032] The specific weight parts of the raw material components are: 40 parts of mugwort powder, 15 parts of safflower powder, 20 parts of dried ginger powder, 20 parts of cinnamon twig powder, 25 parts of radix polygoni lobata powder, 25 parts of papaya powder, and 10 parts of licorice powder.

[0033] A method for preparing a concentrated foot-soaking liquid for dispelling dampness and cold, comprising the following steps:

[0034] S1. Raw material pretreatment: Weigh all raw materials according to the formula ratio, dry them until the moisture content is less than 10%, and then coarsely chop them into small pieces with a diameter of 5-10 mm;

[0035] S2. Ultrafine grinding:

[0036] S21, coarse crushing: the pre-treated medicinal materials are put into a coarse crusher and crushed into particles with a particle size of 1-3 mm at a speed of 800-1200 r / min;

[0037] S22, fine grinding: the coarsely crushed particles are screened through a vibrating screen and then put into a fine grinder, and ground into 200-300 mesh powder at a speed of 2000-3000 r / min;

[0038] S23, ultrafine grinding: the finely ground powder is crushed by using an airflow ultrafine grinder at a pressure of 0.5-0.8 MPa and an airflow velocity of 300-500 m / s, the particle size is controlled to be less than 5-10 μm, and the grinding temperature is controlled at 20-30°C;

[0039] S3, mixing and stirring: put the ultrafinely crushed raw material powders into a high-speed mixer in proportion, and stir at a speed of 600-1000 r / min for not less than 30 minutes;

[0040] S4, extraction and concentration: the mixed powder is put into a supercritical extraction device, with carbon dioxide as the extraction agent, and extracted at a pressure of 20-30 MPa and a temperature of 40-50°C for 2-3 hours to separate and obtain a concentrated solution;

[0041] S5, filtering and removing impurities: the concentrate is filtered under reduced pressure through 100 mesh, 200 mesh and 300 mesh filters in sequence;

[0042] S6. Irradiation sterilization: The filtered concentrate is sterilized by γ-ray irradiation at a dose of 5-10 kGy;

[0043] S7. Finished product packaging: Aseptically package the sterilized concentrated foot bath liquid according to specifications.

[0044] In step S1, the drying process adopts hot air circulation drying, the drying temperature is 40-60° C., and the drying time is 2-4 hours.

[0045] By combining a variety of Chinese medicinal materials and adopting advanced processes such as ultrafine grinding, supercritical extraction and irradiation sterilization, the problems of existing foot-soaking products such as single ingredients, simple preparation process and unreasonable dosage form design have been effectively solved. Compared with traditional foot-soaking liquids, the dissolution rate of the effective ingredients in the product of the present invention is increased by 30%-50%, and the efficacy is more significant. At the same time, it is optimized into a bagged concentrated type. A large package contains 7 small packages, each small package is 40ml, which accurately matches the single foot-soaking dosage, is easy to carry, and avoids pollution and waste. In addition, irradiation sterilization technology replaces chemical preservatives, so that the product's microbial limits meet the pharmacopoeia standards, and the shelf life is extended to 18-24 months, which significantly improves the safety and stability of the product.

[0046] Cooling water is introduced into the grinding chamber of the airflow ultrafine grinder for cooling, so as to accurately control the temperature during the grinding process and maintain it in the appropriate range of 20-30°C, effectively preventing the denaturation or loss of effective ingredients in the medicinal materials due to excessive friction and heat generation, ensuring the stable effect of the medicine, and at the same time improving the grinding efficiency and quality, laying a solid foundation for the preparation of high-quality dehumidifying and cold-relieving concentrated foot bath liquid.

[0047] In step S4, after the supercritical extraction process is completed, the system temperature is reduced to 5-15°C and the pressure is reduced to 5-10MPa through precise decompression and cooling operations. With the help of this change in physical conditions, the carbon dioxide and the active ingredients are fully separated, thereby accurately obtaining a concentrated solution rich in active ingredients, providing high-quality raw materials for subsequent process flows.

[0048] In step S5, the clarity of the concentrate after vacuum filtration through 100-mesh, 200-mesh, and 300-mesh filters can be stably achieved at over 95%. This means that there are almost no impurity particles or suspended matter in the solution that affect the clarity, ensuring the purity and stability of the concentrate, and ensuring the quality and use effect of the final product.

[0049] In step S7, the packaging material used is bagged. Specifically, a complete packaging unit contains seven independent packaging units. This design allows users to use the solution in batches as needed, preventing the solution from being exposed to the elements after opening, which can affect its quality. Each independent packaging unit precisely controls the solution volume to 40ml, ensuring sufficient liquid for a single foot soak while also being easy to carry and store, meeting the dual requirements of portability and practicality for modern consumers.

[0050] In order to determine the best formula and preparation process of concentrated foot soaking liquid for dispelling dampness and cold, the following experiments were conducted;

[0051] (1) Experimental materials

[0052] All examples and comparative examples used the following raw materials: mugwort leaf powder, safflower powder, dried ginger powder, cinnamon twig powder, radix polygoni lobata powder, papaya powder, and liquorice powder;

[0053] The above raw materials are all purchased from regular suppliers and their quality meets the relevant national standards.

[0054] (2) Experimental equipment

[0055] Coarse crusher, fine grinder, air flow ultrafine pulverizer, high-speed mixer, supercritical extraction device, 100 mesh filter, 200 mesh filter, 300 mesh filter, gamma ray irradiation sterilization equipment, aseptic packaging equipment;

[0056] All the above equipment have been calibrated and verified to ensure the accuracy of the experimental results.

[0057] According to the above preparation method, the following formulas were used for experiments:

[0058] Example 1: 30 parts of mugwort powder, 10 parts of safflower powder, 15 parts of dried ginger powder, 15 parts of cinnamon twig powder, 20 parts of radix polygoni lobata powder, 20 parts of papaya powder, and 5 parts of liquorice powder.

[0059] Example 2: 40 parts of mugwort powder, 15 parts of safflower powder, 20 parts of dried ginger powder, 20 parts of cinnamon twig powder, 25 parts of radix polygoni lobata powder, 25 parts of papaya powder, and 10 parts of liquorice powder.

[0060] Example 3: 50 parts of mugwort powder, 20 parts of safflower powder, 25 parts of dried ginger powder, 25 parts of cinnamon twig powder, 30 parts of radix polygoni lobata powder, 30 parts of papaya powder, and 15 parts of liquorice powder.

[0061] Comparative Example 1: 15 parts of safflower pollen, 20 parts of dried ginger powder, 20 parts of cinnamon twig powder, 25 parts of radix polygoni lobatae powder, 25 parts of papaya powder, and 10 parts of liquorice powder. Compared with Example 2, it lacks mugwort powder.

[0062] Comparative Example 2: 40 parts of mugwort powder, 20 parts of dried ginger powder, 20 parts of cinnamon twig powder, 25 parts of radix polygoni lobatae powder, 25 parts of papaya powder, and 10 parts of liquorice powder. Compared with Example 2, it lacks safflower pollen.

[0063] Comparative Example 3: 40 parts of mugwort powder, 15 parts of safflower powder, 20 parts of cassia twig powder, 25 parts of radix polygoni lobatae powder, 25 parts of papaya powder, and 10 parts of liquorice powder. Compared with Example 2, it lacks dried ginger powder.

[0064] The foot soaking liquid prepared in each embodiment and comparative example was measured for the following indicators:

[0065] 1. Dissolution rate of active ingredients: Use high performance liquid chromatography to determine the content of the main active ingredients and calculate the dissolution rate.

[0066] 2. Clarity: Use a clarity tester to measure the clarity of the concentrate.

[0067] 3. Microbial limit: The microbial content shall be tested according to the method specified in the Pharmacopoeia of the People's Republic of China.

[0068] 3. Comfort: Through trial use with 20 volunteers, the comfort level during use was recorded, including skin irritation and temperature perception.

[0069] 4. Shelf life: Under the specified storage conditions, regularly test the quality changes of the foot bath liquid to determine the shelf life.

[0070] Comparative analysis table 1:

[0071]

[0072] The following conclusions can be drawn from Table 1:

[0073] Dissolution rate of active ingredients

[0074] Example 2 performed best: the dissolution rate of the active ingredient in Example 2 was 85%, which was higher than 75% in Example 1 and 80% in Example 3. This shows that the specific ratio in claim 2 can fully dissolve the active ingredients of each raw material, which is more conducive to exerting the efficacy.

[0075] The comparative examples are significantly reduced: the dissolution rates of the active ingredients in comparative examples 1-3 are significantly lower than those in the embodiments, especially comparative example 1 which lacks wormwood powder is only 60%, comparative example 2 which lacks safflower pollen is 65%, and comparative example 3 which lacks dried ginger powder is 62%. This shows that each raw material in the formula plays an important role in the dissolution of the active ingredient. The lack of any raw material will lead to a significant decrease in the dissolution rate, affecting the efficacy of the foot bath.

[0076] Clarity

[0077] Example 2 is still superior: the clarity of Example 2 reaches 96%, Example 1 is 92%, and Example 3 is 90%, which shows that the ratio of claim 2 helps to prepare a clearer concentrate, which may be related to the optimization of the raw material ratio and the synergistic effect of the ultrafine grinding effect.

[0078] The clarity of the comparative examples is low: the clarity of comparative examples 1-3 is also low, which are 85%, 88%, and 86%, respectively. This may be because the stability of the system is affected by the lack of key raw materials, resulting in an increase in impurities in the solution or the particles are difficult to settle, affecting the clarity.

[0079] Microbial limits

[0080] Example 2 is the lowest: Example 2 has the lowest microbial limit, which is only ≤50 CFU / mL, which is better than ≤100 CFU / mL of Example 1 and ≤80 CFU / mL of Example 3. This shows that its optimized preparation process, especially the irradiation sterilization step, can kill microorganisms more effectively and ensure the hygienic safety of the product.

[0081] The comparative examples are relatively high: the microbial limits of comparative examples 1, 2, and 3 are relatively high, which are ≤120 CFU / mL, ≤110 CFU / mL, and ≤115 CFU / mL, respectively. This may be because the antibacterial ability of the system decreases due to the lack of certain raw materials, or the control effect of the preparation process on microorganisms is not as effective as the process in Example 2.

[0082] On the whole, the specific ratio in Example 2 performs well in the three key indicators of effective ingredient dissolution rate, clarity and microbial limit, which can significantly improve the quality and performance of the foot bath liquid, and is the best formula choice. The control ratio lacking any raw material has a significant decrease in these three indicators, indicating that the reasonable ratio of the raw materials in the formula is crucial to the quality and effect of the foot bath liquid.

[0083] Comparative analysis table 2:

[0084]

[0085] The following conclusions can be drawn from Table 2:

[0086] Analysis of user comfort

[0087] Example 2 is the best: The comfort level of Example 2 is "excellent", indicating that its formula and preparation process are very reasonable, the foot bath liquid prepared has no obvious irritation to the skin during use, has good temperature perception, and provides a good user experience.

[0088] Example 1 and Example 13 are next: the comfort of use of Examples 1 and 3 is "good". Although there is no obvious discomfort, there are slight flaws. For example, Example 1 may have slight irritation to the skin due to the insufficient optimization of the raw material ratio; Example 3 may have a certain burden on the skin due to some ingredients being too high in raw material content.

[0089] The comparison examples are poor: the comfort of use of comparison examples 1, 2 and 3 is only average. Due to the lack of key raw materials, the performance of the foot bath liquid is incomplete, and problems such as skin irritation or poor temperature perception may occur, and the use experience is not ideal.

[0090] Shelf life analysis

[0091] Example 2 is the longest: The shelf life of Example 2 reaches 18 months, which is mainly due to its scientific and reasonable formula and advanced preparation process, especially the application of irradiation sterilization technology, which can effectively kill microorganisms without destroying the active ingredients, so that the quality of the product is stable during storage.

[0092] Example 1 and Example 3 are shorter: The shelf life of Example 1 and Example 3 are 16 months and 17 months, respectively. Although they are longer, they are not as good as Example 2. The raw material ratio of Example 1 is not optimized enough, and the raw material content of Example 3 is too high, which may lead to slightly poor system stability and insufficient anti-deterioration ability, thereby shortening the shelf life.

[0093] The comparative examples are relatively short: the shelf life of comparative examples 1, 2 and 3 is only 12-13 months. The lack of key raw materials reduces the overall performance of the foot bath liquid, deteriorates the stability, and makes it more prone to deterioration.

[0094] Comprehensive analysis

[0095] The specific ratio in Example 2 performs best in terms of comfort of use and shelf life, and can provide consumers with a high-quality, safe, long-lasting and effective foot soaking experience.

[0096] In contrast, the lack of any key raw material will significantly reduce the comfort of use and shorten the shelf life, highlighting the importance of a complete formula to the quality and performance of foot bath liquid.

[0097] Combining Table 1 and Table 2, the specific ratios in Example 2 perform well in all indicators, can significantly improve the quality and performance of the foot bath liquid, and is the best formula choice.

[0098] The basic principles, main features, and advantages of the present invention are shown and described above. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The above embodiments and descriptions are merely illustrative of the principles of the present invention. Various changes and modifications may be made to the present invention without departing from the spirit and scope of the present invention. Such changes and modifications are intended to fall within the scope of the present invention. The scope of protection claimed in the present invention is defined by the appended claims and their equivalents.

Claims

1. A concentrated foot soaking liquid for dispelling dampness and cold, characterized in that: The invention comprises the following raw material components in parts by weight: 30-50 parts of mugwort leaf powder, 10-20 parts of safflower powder, 15-25 parts of dried ginger powder, 15-25 parts of cassia twig powder, 20-30 parts of radix polygoni lobatae powder, 20-30 parts of papaya powder and 5-15 parts of liquorice powder.

2. The concentrated foot-soaking liquid for dispelling dampness and cold according to claim 1, characterized in that The specific weight parts of the raw material components are: 40 parts of mugwort powder, 15 parts of safflower powder, 20 parts of dried ginger powder, 20 parts of cassia twig powder, 25 parts of radix polygoni lobata powder, 25 parts of papaya powder, and 10 parts of licorice powder.

3. A method for preparing the concentrated foot-soaking liquid for dispelling dampness and cold as claimed in claims 1 and 2, characterized in that: The following steps are involved: S1. Raw material pretreatment: Weigh all raw materials according to the formula ratio, dry them until the moisture content is less than 10%, and then coarsely chop them into small pieces with a diameter of 5-10 mm; S2. Ultrafine grinding: S21, coarse crushing: the pre-treated medicinal materials are put into a coarse crusher and crushed into particles with a particle size of 1-3 mm at a speed of 800-1200 r / min; S22, fine grinding: the coarsely crushed particles are screened through a vibrating screen and then put into a fine grinder, and ground into 200-300 mesh powder at a speed of 2000-3000 r / min; S23, ultrafine grinding: the finely ground powder is crushed by using an airflow ultrafine grinder at a pressure of 0.5-0.8 MPa and an airflow velocity of 300-500 m / s, the particle size is controlled to be less than 5-10 μm, and the grinding temperature is controlled at 20-30°C; S3, mixing and stirring: put the ultrafinely crushed raw material powders into a high-speed mixer in proportion, and stir at a speed of 600-1000 r / min for not less than 30 minutes; S4, extraction and concentration: the mixed powder is put into a supercritical extraction device, with carbon dioxide as the extraction agent, and extracted at a pressure of 20-30 MPa and a temperature of 40-50°C for 2-3 hours to separate and obtain a concentrated solution; S5, filtering and removing impurities: the concentrate is filtered under reduced pressure through 100 mesh, 200 mesh and 300 mesh filters in sequence; S6. Irradiation sterilization: The filtered concentrate is sterilized by γ-ray irradiation at a dose of 5-10 kGy; S7. Finished product packaging: Aseptically package the sterilized concentrated foot bath liquid according to specifications.

4. The preparation method according to claim 3, characterized in that In step S1, the drying process adopts hot air circulation drying, the drying temperature is 40-60° C., and the drying time is 2-4 hours.

5. The preparation method according to claim 3, characterized in that In step S23, cooling water is introduced into the grinding chamber of the airflow superfine grinder to reduce the temperature so as to control the grinding temperature.

6. The preparation method according to claim 3, characterized in that In step S4, after supercritical extraction, the temperature is reduced to 5-15° C. and the pressure is reduced to 5-10 MPa for separation to obtain a concentrated solution.

7. The preparation method according to claim 3, characterized in that In step S5, the clarity of the filtered concentrated liquid reaches above 95%.

8. The preparation method according to claim 3, characterized in that In step S7, the packaging material is in bag form, one packaging unit contains 7 independent packaging units, and the solution volume of each independent packaging unit is 40 ml.

Images