Composite carrier for targeted drug delivery based on diatom shells

Through the grading channel design and multi-layer structure of the diatom shell composite carrier, combined with Fe3O4 magnetic nanoparticles and temperature-sensitive polymer film, the multifunctional synergy problem of the existing diatom shell delivery system is solved, precise targeting, high-efficiency drug loading and controlled release are achieved, and the cancer treatment effect is significantly improved.

CN120478658APending Publication Date: 2025-08-15YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI +1
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Patent Information

Application Number
CN202510373720.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-03-27
Publication Date
2025-08-15

AI Technical Summary

Technical Problem

The existing drug delivery system based on diatom shells is difficult to achieve multifunctional synergy. There is a drug that is prone to fall off in the physiological environment and cannot meet the co-delivery needs of drugs of different properties in combination therapy, and the traditional preparation process has limited adaptability.

Method used

Through hierarchical channel design, interface engineering technology and multi-layer structure construction, combined with Fe3O4 magnetic nanoparticles and temperature-sensitive polymer film, magnetic targeting, temperature-sensitive controlled release and in vivo stability are achieved, and Schiff alkali bonds and amide bonds are used to ensure the stability of the functional layer, and dual-drug layered loading and anti-immune clearance design.

Benefits of technology

It has achieved precise targeting, high-efficiency drug loading, time-sequential controlled release and in vivo stability, improved targeting efficiency, controllability of drug release and biocompatibility, and significantly enhanced the cancer treatment effect.

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Abstract

The invention relates to the field of biomedical materials, in particular to a composite carrier for targeted drug delivery based on a diatom shell, and the carrier utilizes a natural diatom shell porous structure to anchor FeOmagnetic nanoparticles and graft a PNIPAM-co-AAc temperature-sensitive polymer film on the shell surface through oxygen plasma pretreatment and Schiff base reaction. The carrier realizes double-drug loading: a hydrophobic drug is loaded in a shell pore channel, and a hydrophilic drug is adsorbed on the surface of the membrane. And the anti-immune layer is grafted through a PEG silane coupling agent, so that the in-vivo circulation is prolonged to 45 hours. Heat is generated to 42-45 DEG C in an alternating magnetic field to trigger the temperature-sensitive film to shrink and release drugs, meanwhile, cancer cells are directly killed through thermal therapy, and the tumor inhibition rate reaches 78% and is remarkably improved compared with a traditional magnetic targeting carrier. Precise synergy of magnetic hyperthermia and drug release is achieved through structural innovation, and an efficient and low-toxicity solution is provided for cancer treatment.
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