MIDI music modulation stimulation method, system and device under magnetic stimulation

Abstract

The invention provides an MIDI music modulation stimulation method under magnetic stimulation, which comprises the following steps of: extracting audio track data into a two-dimensional array A, traversing the two-dimensional array A, merging the audio track data with the same starting time, and obtaining a two-dimensional array B when the product of strength and pitch is maximum; performing linear normalization processing on the product of the strength and the pitch in the two-dimensional array B to obtain a two-dimensional array C; converting the two-dimensional array C into a corresponding TMS stimulation sequence array D; the TMS stimulation sequence array D issues a data frame to the processor module, the data frame is written into an annular queue after CRC is verified, then the data frame is broadcasted to the control signal generation module for ID filtering, and the control signal generation module reads a task command of the processor module; the PC plays music and starts stimulation at the same time, the signal generation module is controlled to carry out intensity adjustment and output a boost signal to the charging and discharging module, ordered charging and discharging stimulation is carried out according to a stimulation music mode, and discharging stimulation is carried out to release electric energy on the energy storage capacitor to the magnetic stimulation coil.

Description

Technical Field

[0001] The present invention relates to the technical field of transcranial stimulation therapy, and in particular to a MIDI music modulation stimulation method, system and device under magnetic stimulation. Background Art

[0002] Currently, transcranial magnetic stimulation (TMS) devices are used clinically in the following stimulation modes: 1. Single-shot stimulation mode, with manual triggering, resulting in one stimulation per trigger; 2. Standard stimulation mode, with a fixed frequency and intensity; and 3. Burst stimulation mode, also known as TBS in the literature, with an intra-cluster frequency of 50 Hz and an inter-cluster frequency of 5 Hz. These modes are relatively limited and cannot meet the needs of personalized treatments, resulting in the inability to tailor stimulation treatment plans to individual patient preferences.

[0003] In view of this, it is necessary to provide a MIDI music modulation stimulation method, system and device under magnetic stimulation to solve the above problems. Summary of the Invention

[0004] The purpose of the present invention is to provide a MIDI music modulation stimulation method, system and device under magnetic stimulation. By making the magnetic stimulation frequency consistent with the music melody and the intensity of the magnetic stimulation changing with the strength of the music melody, a new magnetic stimulation mode is obtained, which can meet the patient's personalized stimulation treatment needs.

[0005] In order to achieve the above object, the technical solution proposed by the present invention is implemented as follows: a MIDI music modulation stimulation method under magnetic stimulation, comprising the following steps:

[0006] S1. Extract all track data into a two-dimensional array A, traverse the two-dimensional array A, merge the two-dimensional arrays with the same "start time" in A, and take the maximum product of the velocity and pitch in the two-dimensional array A to obtain a new two-dimensional array B;

[0007] S2. Linearly normalize the product of the velocity and pitch in the two-dimensional array B and linearly map it to the range [0, 1] to obtain a two-dimensional array C;

[0008] S3, convert the two-dimensional array C into the corresponding TMS stimulation sequence array D;

[0009] S4. Set the music mode on the PC, add the TMS stimulation sequence array D to the CAN ID and send the data frame to the processor module. After checking the CRC, write it into the circular queue. Then, the processor module broadcasts it to the control signal generation module for ID filtering. The control signal generation module automatically recognizes the CAN ID and reads the task command of the processor module.

[0010] S5. The PC starts playing music and starts stimulation at the same time. The control signal generation module adjusts the intensity and outputs a boost signal to the charge and discharge module. The charge and discharge module performs orderly charging and discharging according to the stimulating music pattern, first raising the energy storage capacitor voltage to the target voltage; and then performing discharge stimulation to release the electrical energy on the energy storage capacitor to the stimulation coil.

[0011] Preferably, the two-dimensional array C is converted into a corresponding TMS stimulation sequence array D, wherein the stimulation intensity is specified between the minimum value V1 and the maximum value V2. The product of the normalized force and pitch is converted into a magnetic stimulation intensity within the range of the minimum value V1 and the maximum value V2 by formula (a), and the stimulation time point corresponds to the "start time" in the two-dimensional array C. In this way, the TMS stimulation sequence array D is obtained.

[0012] Formula (a) Magnetic stimulation intensity = product of force and pitch * (maximum value V2 - minimum value V1) + minimum value V1.

[0013] Preferably, when performing discharge stimulation, the charging and discharging module outputs a unidirectional electronic switch signal according to the stimulation timing of the data frame sent under the music mode stimulation. In the discharge interval, the unidirectional electronic switch is turned on to release the electrical energy on the energy storage capacitor to the stimulation coil; in the charging interval, the unidirectional electronic switch is closed, and the electrical energy on the stimulation coil reversely charges the capacitor, and the charging module charges the capacitor at the same time.

[0014] A system for a MIDI music modulation stimulation method under magnetic stimulation comprises: a PC, a processor module, an acquisition module, a human-computer interaction module, and a control signal generating module; the processor module is communicatively connected to the PC via a network or a USB cable, the acquisition module is communicatively connected to the processor module, the acquisition module is communicatively connected to the processor module, the human-computer interaction module and the control signal generating module are communicatively connected to the processor module, and the control signal generating module is electrically connected to a charge and discharge module;

[0015] The PC can send a task command to the processor module, and the processor module processes the data according to the task command and sends it to the control signal generation module. The signal control generation module adjusts the charge and discharge intensity of the charge and discharge module and releases it to the magnetic stimulation coil. The acquisition module collects the patient's EEG signal and sends it to the processor module. After receiving the EEG signal, the processor module uploads it to the PC and displays it on the human-computer interaction module.

[0016] Preferably, the MIDI music modulation stimulation system under magnetic stimulation also includes a cooling system, which includes a water tank, a flow sensor, a temperature sensor, a water pump and an air pump; the flow sensor and the temperature sensor are both arranged in the water tank and electrically connected to the PC, the water pump is connected between the outlet of the water tank and the inlet of the magnetic stimulation coil, the air pump is connected between the water pump and the inlet of the magnetic stimulation coil, and the outlet of the magnetic stimulation coil is connected to the water tank.

[0017] An electronic device comprises a memory, a processor and a computer program stored in the memory and operable on the processor. When the processor executes the program, the steps of a MIDI music modulation stimulation method under magnetic stimulation are realized.

[0018] A non-transitory computer-readable storage medium stores a computer program, which, when executed by a processor, implements the steps of a MIDI music modulation stimulation method under magnetic stimulation.

[0019] A computer program product comprises a computer program, which, when executed by a processor, implements the steps of a MIDI music modulation stimulation method under magnetic stimulation.

[0020] Compared with the existing technology, the beneficial effects are: 1) by making the magnetic stimulation frequency consistent with the music melody, and the intensity of the magnetic stimulation changes with the strength of the music melody, a new magnetic stimulation mode is obtained, which can meet the patient's personalized stimulation treatment needs;

[0021] 2) The event with the largest product of pitch and velocity is selected as the representative value, thereby generating a time-aligned optimized two-dimensional array B. This two-dimensional array B not only retains the multi-track information of the MIDI music file, but also enhances the expressiveness of the music data through the fusion of pitch and velocity, providing an efficient and accurate data foundation for subsequent music analysis, synthesis and processing.

[0022] Other features and advantages of the present invention will be set forth in the following description, and part will be apparent from the description, or may be understood through practice of the present invention. Features and advantages of the present invention may be realized and obtained through the elements and combinations specifically indicated in the appended claims. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for use in the embodiments. It should be understood that the following drawings only illustrate certain embodiments of the present invention and should not be considered as limiting the scope. A person of ordinary skill in the art can also derive other relevant drawings based on these drawings without inventive effort.

[0024] Figure 1 This is a schematic diagram of the principle of MIDI music modulation stimulation under magnetic stimulation provided by the present invention.

[0025] Figure 2 Schematic diagram of the specified timing of the data frame output under music mode stimulation. DETAILED DESCRIPTION

[0026] In order to make the purpose, technical solution and beneficial technical effects of the present invention more clear, the present invention is further described in detail below with reference to the accompanying drawings and specific embodiments. It should be understood that the specific embodiments described in this specification are only for the purpose of explaining the present invention and are not intended to limit the present invention.

[0027] It should be understood that the terms "upper", "lower", "front", "back", "left", "right", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship, are based on the orientation or position relationship shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operate in a specific orientation, and therefore cannot be understood as limiting the present invention.

[0028] It should also be noted that, unless otherwise expressly specified or limited, terms such as "installed," "connected," "connect," "fixed," and "set" should be understood broadly. For example, they may refer to fixed or detachable connections, or integration; mechanical or electrical connections; direct or indirect connections through an intermediate medium; and internal communication between two components or interaction between two components. Those skilled in the art will readily understand the specific meanings of these terms in the present invention based on specific circumstances.

[0029] Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the quantity of the technical features being referred to. Thus, a feature identified as "first," "second," or "third" may explicitly or implicitly include one or more of such features. Furthermore, "plurality" and "several" refer to two or more, unless otherwise specifically defined.

[0030] See also Figures 1 to 2The present invention proposes a MIDI music modulation stimulation system under magnetic stimulation, comprising: a PC, a processor module, an acquisition module, a human-computer interaction module, and a control signal generating module; the processor module is communicatively connected to the PC via a network or a USB cable, the acquisition module is communicatively connected to the processor module via an SPI (Serial Peripheral Interface) bus, and the acquisition module is further communicatively connected to the processor module via a CAN (Controller Area Network, CAN) line; the human-computer interaction module and the control signal generating module are communicatively connected to the processor module, and the control signal generating module is electrically connected to a charge and discharge module;

[0031] The PC can send a task command to the processor module, and the processor module processes the data according to the task command and sends it to the control signal generation module. The signal control generation module adjusts the charge and discharge intensity of the charge and discharge module and releases it to the magnetic stimulation coil. The acquisition module collects the patient's EEG signal and sends it to the processor module. After receiving the EEG signal, the processor module uploads it to the PC and displays it on the human-computer interaction module.

[0032] It should be noted that, in this embodiment, the human-computer interaction interface may be a touch screen.

[0033] In a preferred embodiment, the MIDI music modulation stimulation system under magnetic stimulation also includes a cooling system, which includes a water tank, a flow sensor, a temperature sensor, a water pump and an air pump; the flow sensor and the temperature sensor are both arranged in the water tank and electrically connected to the PC, the water pump is connected between the outlet of the water tank and the inlet of the magnetic stimulation coil, the air pump is connected between the water pump and the inlet of the magnetic stimulation coil, and the outlet of the magnetic stimulation coil is connected to the water tank.

[0034] During stimulation, the operator issues a start command to the cooling system's water pump and air pump via a PC. The water pump starts, and the cooling medium in the water tank enters the pump under its action. It then enters the magnetic stimulation coil to reduce its temperature and flows back into the water tank. The flow sensor detects the cooling medium's flow rate, and the temperature sensor detects the cooling medium's temperature. The detected flow and temperature information are uploaded to the PC, and the PC's touch screen displays the flow and temperature information to monitor the cooling medium's circulation status. It should be noted that in this embodiment, the cooling medium is water and oil.

[0035] The present invention also provides a MIDI music modulation stimulation method under magnetic stimulation, which obtains a new magnetic stimulation mode by making the magnetic stimulation frequency consistent with the music melody and the intensity of the magnetic stimulation changing with the strength of the music melody; the method comprises the following steps:

[0036] S1. Get MIDI music melody. Extract all track data (take the start time of the NOTE ON message, the product of velocity and pitch) into a two-dimensional array A. Traverse the two-dimensional array A and merge the two-dimensional arrays with the same "start time". Take the largest product of velocity and pitch in the two-dimensional array A.

[0037] In this way, a new two-dimensional array B is obtained, for example, {[250, 57*80], [500, 61*80]...}, with a time precision of milliseconds. The start time in the above examples is 250 milliseconds and 500 milliseconds.

[0038] S2. Linearly normalize the product of the velocity and pitch in the two-dimensional array B and linearly map it to the range of [0, 1] to obtain a two-dimensional array C, for example: {[250, 0.5][500, 0.7]...}.

[0039] S3. Based on the two-dimensional array C obtained above, convert the two-dimensional array C into the corresponding TMS stimulation sequence array D, where the stimulation intensity can be specified in a range (specified between the minimum value V1 and the maximum value V2). Formula (a) can be used to convert the product of the normalized force and pitch into a magnetic stimulation intensity within the range of the minimum value V1 and the maximum value V2, and the moment of stimulation corresponds to the "start time" in the two-dimensional array C. In this way, the TMS stimulation sequence array D is obtained.

[0040] Assuming V1 = 10, V2 = 60, the TMS stimulation sequence corresponding to the music melody array {[250, 0.5][500, 0.7]...} is {[250, 35][500, 45]...},

[0041] (a) Magnetic stimulation intensity = product of force and pitch * (maximum value V2 - minimum value V1) + minimum value V1;

[0042] S4, sending the TMS stimulation sequence array D to the processor module;

[0043] Set the music mode on the modulation stimulation interface of the PC, add the TMS stimulation sequence array D to the CAN ID and send the data frame to the processor module through the network or USB cable. After checking the CRC, write it into the circular queue, and then broadcast it to the CAN bus through the processor module for ID filtering from the module's control signal generation module.

[0044] The control signal generation module of the CAN bus slave module automatically identifies the CAN ID and reads the task command from the processor module. For example, the control signal generation module reads the cooling task command transmitted from the processor module via the CAN bus and sends a control signal to the cooling system module to start the water pump and fan.

[0045] S5, play music and start TMS stimulation;

[0046] After the stimulation is started, the PC starts playing music and starts the stimulation at the same time. The control signal generation module first adjusts the intensity and outputs a boost signal to the charge and discharge module. The charge and discharge module first increases the voltage of the energy storage capacitor to the target voltage according to the stimulation music mode to perform orderly charge and discharge stimulation; then, during the discharge stimulation, the electrical energy on the energy storage capacitor is released to the stimulation coil for transcranial stimulation treatment of the patient.

[0047] Before the next activation, the capacitor voltage needs to be charged to the target voltage, and this process is repeated. Repetitive magnetic stimulation outputs the specified timing according to the frequency f, intermittent time, charging interval, discharging interval, cycle and other parameters set in the data frame sent by the music mode stimulation.

[0048] During discharge stimulation, the charge and discharge module outputs a unidirectional electronic switch signal according to the stimulation timing of the data frame sent by the music mode stimulation. In the discharge interval, the unidirectional electronic switch is turned on to release the electrical energy on the energy storage capacitor to the stimulation coil; in the charging interval, the unidirectional electronic switch is closed, and the electrical energy on the stimulation coil reversely charges the capacitor, and the charging module charges the capacitor at the same time.

[0049] Through the description of the above embodiments, those skilled in the art can clearly understand that each embodiment can be implemented by means of software plus a necessary general hardware platform, or of course, by hardware. Based on this understanding, the essence of the above technical solution or the part that contributes to the existing technology can be embodied in the form of a software product. The computer software product can be stored in a computer-readable storage medium, such as ROM / RAM, a magnetic disk, an optical disk, etc., and includes a number of instructions for enabling a computer device (which can be a personal computer, a server, or a network device, etc.) to execute the methods described in each embodiment or certain parts of the embodiments.

[0050] In particular, according to some embodiments of the present disclosure, the process described above can be implemented as a computer software program. For example, some embodiments of the present disclosure include a computer program product, which includes a computer program carried on a computer-readable medium, and the computer program includes program code for executing the method shown in the flowchart. In some such embodiments, the computer program can be downloaded and installed from a network via a communication device, or installed from a storage device, or installed from a ROM. When the computer program is executed by a processing device, the above-mentioned functions defined in the method of some embodiments of the present disclosure are performed.

[0051] It should be noted that the computer-readable medium described in some embodiments of the present disclosure may be a computer-readable signal medium or a computer-readable storage medium, or any combination thereof. A computer-readable storage medium may be, for example, but not limited to, an electrical, magnetic, optical, electromagnetic, infrared, or semiconductor system, device, or component, or any combination thereof. More specific examples of computer-readable storage media may include, but are not limited to, an electrical connection having one or more wires, a portable computer disk, a hard disk, a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), optical fiber, a portable compact disk read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination thereof. In some embodiments of the present disclosure, a computer-readable storage medium may be any tangible medium containing or storing a program that can be used by or in conjunction with an instruction execution system, device, or component. Furthermore, in some embodiments of the present disclosure, a computer-readable signal medium may include a mission data signal propagated in baseband or as part of a carrier wave, which carries computer-readable program code. This propagated mission data signal may take a variety of forms, including but not limited to electromagnetic signals, optical signals, or any suitable combination thereof. A computer-readable signal medium may also be any computer-readable medium other than a computer-readable storage medium that can transmit, propagate, or transport a program for use by or in conjunction with an instruction execution system, apparatus, or device. The program code contained on the computer-readable medium may be transmitted using any suitable medium, including but not limited to wires, optical cables, RF (radio frequency), etc., or any suitable combination thereof.

[0052] In some embodiments, the client and server can communicate using any currently known or future developed network protocol, such as HTTP (HyperText Transfer Protocol), and can be interconnected with any form or medium of digital task data communication (e.g., a communication network). Examples of communication networks include local area networks ("LAN"), wide area networks ("WAN"), internets (e.g., the Internet), and peer-to-peer networks (e.g., adhoc peer-to-peer networks), as well as any currently known or future developed networks.

[0053] The computer-readable medium may be included in the electronic device, or may exist independently without being incorporated into the electronic device. The computer-readable medium carries one or more programs. When the one or more programs are executed by the electronic device, the electronic device: in response to detecting a query operation on a production collaboration document in the switch production line management application, determines the network connection status of the switch production line management application; in response to determining that the network connection status of the switch production line management application represents an offline state, replaces the web page entry information corresponding to the production collaboration document with target entry file information, and loads target web page resource information to display the web page of the production collaboration document offline in the switch production line management application, wherein the target entry file information is file information of a pre-downloaded entry file corresponding to the web page of the production collaboration document, and the target web page resource information is locally stored resource information corresponding to the web page; in response to determining that the network connection status of the switch production line management application represents an online state and the web page resource information corresponding to the production collaboration document is not stored locally, downloads the web page resource information of the web page from the production line document server, wherein the web page resource information includes the entry file and resource information; displays the web page of the production collaboration document in the switch production line management application according to the web page resource information, and stores the web page resource information in a local database.

[0054] Computer program code for performing the operations of some embodiments of the present disclosure may be written in one or more programming languages, or a combination thereof, including product-oriented programming languages such as Java, Smalltalk, C++, and conventional procedural programming languages such as "C" or similar programming languages. The program code may be executed entirely on the user's computer, partially on the user's computer, as a stand-alone software package, partially on the user's computer and partially on a remote computer, or entirely on a remote computer or server. In cases involving a remote computer, the remote computer may be connected to the user's computer through any type of network, including a local area network (LAN) or a wide area network (WAN), or may be connected to an external computer (e.g., through the Internet using an Internet service provider).

[0055] The present invention is not limited to what is described in the specification and embodiments, and additional advantages and modifications will be readily apparent to those skilled in the art. Therefore, the present invention is not limited to the specific details, representative devices, and illustrative examples shown and described herein without departing from the spirit and scope of the general concept defined by the claims and their equivalents.

Claims

1. A MIDI music modulation stimulation method under magnetic stimulation, characterized in that: The steps include: S1. Extract all track data into a two-dimensional array A. Traverse the two-dimensional array A and merge the two-dimensional arrays with the same "start time". Take the maximum product of the velocity and pitch in the two-dimensional array A to obtain a new two-dimensional array B. S2. Linearly normalize the product of the velocity and pitch in the two-dimensional array B and linearly map it to the range [0, 1] to obtain a two-dimensional array C; S3, convert the two-dimensional array C into the corresponding TMS stimulation sequence array D; S4. Set the music mode on the PC, add the TMS stimulation sequence array D to the CAN ID and send the data frame to the processor module. After checking the CRC, write it into the circular queue. Then, the processor module broadcasts it to the control signal generation module for ID filtering. The control signal generation module automatically recognizes the CAN ID and reads the task command of the processor module. S5. The PC starts playing music and starts stimulation at the same time. The control signal generating module adjusts the intensity and outputs a boost signal to the charge and discharge module. The charge and discharge module first increases the voltage of the energy storage capacitor to the target voltage according to the stimulating music mode to perform orderly charge and discharge stimulation, and performs discharge stimulation to release the electrical energy on the energy storage capacitor to the stimulation coil.

2. The MIDI music modulation stimulation method under magnetic stimulation as claimed in claim 1, characterized in that: Convert the two-dimensional array C into the corresponding TMS stimulation sequence array D, where the stimulation intensity is specified between the minimum value V1 and the maximum value V2. Use formula (a) to convert the product of the normalized force and pitch into a magnetic stimulation intensity within the range of the minimum value V1 and the maximum value V2. The stimulation time point corresponds to the "start time" in the two-dimensional array C. In this way, the TMS stimulation sequence array D is obtained. Formula (a) Magnetic stimulation intensity = product of force and pitch * (maximum value V2 - minimum value V1) + minimum value V1.

3. The MIDI music modulation stimulation method under magnetic stimulation as claimed in claim 1, characterized in that: During discharge stimulation, the charge and discharge module outputs a unidirectional electronic switch signal according to the stimulation timing of the data frame sent by the music mode stimulation. In the discharge interval, the unidirectional electronic switch is turned on to release the electrical energy on the energy storage capacitor to the stimulation coil; in the charging interval, the unidirectional electronic switch is closed, and the electrical energy on the stimulation coil reversely charges the capacitor, and the charging module charges the capacitor at the same time.

4. A system for the MIDI music modulation stimulation method under magnetic stimulation according to any one of claims 1 to 3, characterized in that: include: PC, processor module, acquisition module, human-computer interaction module and control signal generation module; The processor module is communicatively connected to the PC via a network or a USB cable, the acquisition module is communicatively connected to the processor module, the acquisition module is communicatively connected to the processor module, the human-computer interaction module and the control signal generating module are communicatively connected to the processor module, and the control signal generating module is electrically connected to the charge and discharge module; The PC can send a task command to the processor module, and the processor module processes the data according to the task command and sends it to the control signal generation module. The signal control generation module adjusts the charge and discharge intensity of the charge and discharge module and releases it to the magnetic stimulation coil. The acquisition module collects the patient's EEG signal and sends it to the processor module. After receiving the EEG signal, the processor module uploads it to the PC and displays it on the human-computer interaction module.

5. The MIDI music modulation stimulation system under magnetic stimulation as claimed in claim 4, characterized in that: The MIDI music modulation stimulation system under magnetic stimulation also includes a cooling system, which includes a water tank, a flow sensor, a temperature sensor, a water pump and an air pump; the flow sensor and the temperature sensor are both arranged in the water tank and electrically connected to the PC, the water pump is connected between the outlet of the water tank and the inlet of the magnetic stimulation coil, the air pump is connected between the water pump and the inlet of the magnetic stimulation coil, and the outlet of the magnetic stimulation coil is connected to the water tank.

6. An electronic device comprising a memory, a processor, and a computer program stored in the memory and executable on the processor, wherein: When the processor executes the program, the steps of the MIDI music modulation stimulation method under magnetic stimulation as described in any one of claims 1 to 3 are implemented.

7. A non-transitory computer-readable storage medium having a computer program stored thereon, characterized in that: When the computer program is executed by a processor, the steps of the MIDI music modulation stimulation method under magnetic stimulation as claimed in any one of claims 1 to 3 are implemented.

8. A computer program product comprising a computer program, characterized in that When the computer program is executed by a processor, the steps of the MIDI music modulation stimulation method under magnetic stimulation as claimed in any one of claims 1 to 3 are implemented.

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