Compound preparation with anti-fatigue, nerve-calming, sleep-aiding and anti-aging functions and preparation method thereof

Abstract

The invention discloses a compound preparation with anti-fatigue, nerve-calming, sleep-aiding and anti-aging functions and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The invention relates to a compound preparation with anti-fatigue, nerve-calming, sleep-aiding and anti-aging functions. The compound preparation mainly comprises the following raw material components: ginseng; fermenting the pomegranate extract; red date polysaccharide; lotus plumule alkali; coix seed oil; polygonatum sibiricum polyphenol; colla corii asini peptide; theaflavin; compound probiotics; according to the invention, probiotics and classic tonifying traditional Chinese medicines are scientifically matched, the bottleneck of component interaction is broken through through a'microorganism-traditional Chinese medicine 'co-fermentation technology, a'qi-blood regulation-viscera balance-cell repair' three-level action model is established, and the requirements of modern medical treatment on functional preparations are met.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and in particular to a composite preparation with anti-fatigue, tranquilizing, sleep-inducing and anti-aging functions and a preparation method thereof. Background Art

[0002] The accelerated pace of modern life has led to a high incidence of problems such as fatigue, insomnia, and neurasthenia. Existing drugs mostly target single symptoms and carry the risk of side effects. Traditional Chinese medicine emphasizes holistic conditioning, but traditional compound preparations have complex ingredients and slow onset of action. Summary of the Invention

[0003] The purpose of the present invention is to solve the problems raised in the above background technology, and to propose a composite preparation with anti-fatigue, tranquilizing, sleep-inducing and anti-aging functions and a preparation method thereof.

[0004] In order to achieve the above object, the present invention adopts the following technical solutions:

[0005] A compound preparation with anti-fatigue, calming, sleep-inducing and anti-aging functions, mainly comprising the following raw materials: ginseng; fermented pomegranate extract; red date polysaccharide; lotus seed core base; coix seed oil; polygonatum polyphenols; donkey-hide gelatin peptide; theaflavins; and compound probiotics.

[0006] Preferably, the content ratio of each raw material component is: ginseng: 15-25%; fermented pomegranate extract: 10-18%; red date polysaccharide: 8-12%; lotus seed heart core alkaloids: 5-10%; coix seed oil: 3-8%; polygonatum polyphenols: 5-10%; donkey-hide gelatin peptide: 8-15%; theaflavins: 2-5%; compound probiotics: 1-3%.

[0007] Preferably, the content ratio of each raw material component is: ginseng: 20%; fermented pomegranate extract: 15%; red date polysaccharide: 10%; nelumbo nucifera alkaloids: 8%; coix seed oil: 5%; polygonatum polyphenols: 8%; donkey-hide gelatin peptide: 12%; theaflavins: 3%; compound probiotics: 2%.

[0008] Preferably, the composite probiotics are composed of Lactobacillus and Bifidobacterium in a 1:1 ratio.

[0009] A method for preparing a composite preparation having anti-fatigue, tranquilizing, sleep-inducing and anti-aging functions mainly comprises the following steps:

[0010] S1. Extract saponin components from ginseng and retain saponin activity;

[0011] S2, fermenting the pomegranate with lactic acid bacteria to obtain polyphenolic compounds;

[0012] S3, extracting red date polysaccharides from red dates, extracting nelumbo nucifera alkaloids from lotus seeds, extracting coix seed oil from coix seeds, and extracting polygonatum polyphenols from polygonatum;

[0013] S4. Take 20% ginseng, 15% fermented pomegranate extract, 10% red date polysaccharide, 8% nelumbo nucifera alkaloids, 5% coix seed oil, 8% polygonatum polyphenols, 12% donkey-hide gelatin peptide, add 3% theaflavins and 2% probiotics, and use fluidized bed coating technology to form after wet granulation.

[0014] Preferably, in steps S1 and S3, the extraction of saponins from ginseng, the extraction of jujube polysaccharides from red dates, the extraction of nelumbo nucifera from lotus seeds, and the extraction of polygonatum polyphenols from polygonatum are performed by ultrasonic-assisted extraction;

[0015] The ultrasonic-assisted extraction method mainly comprises the following steps:

[0016] a. Pre-treating the raw materials: drying the ginseng, red dates, lotus seed core or polygonatum, and crushing the raw materials into powder after drying;

[0017] b. Select a suitable solvent;

[0018] c. Ultrasonic extraction: Mix the raw material powder with the selected solvent and place it in an ultrasonic device;

[0019] Set the ultrasonic parameters, ultrasonic power between 200W-500W, ultrasonic time between 10 minutes and 30 minutes, and extraction temperature between 30℃-60℃ to accelerate the rupture of raw material cells and allow the obtained substance to be quickly dissolved into the solvent;

[0020] d. After the extraction is completed, the desired extract is obtained through filtration, concentration and purification.

[0021] Preferably, the solvent selected for extracting saponins, nelumboside and polygonatum polyphenols in step b is ethanol, and the solvent selected for extracting red date polysaccharides is deionized water.

[0022] Preferably, the extraction of coix seed oil from coix seed in step S3 is performed by microwave-assisted extraction;

[0023] The microwave-assisted extraction method mainly comprises the following steps:

[0024] A. Raw material processing: Wash and dry the coix seeds and then grind them into powder.

[0025] B. Solvent selection and mixing: Use organic solvent ethanol and mix it evenly with coix seed powder.

[0026] C. Microwave extraction: Place the mixture into a microwave extraction device, set the microwave parameters, microwave power between 300W-800W, extraction time between 1-5 minutes, and temperature between 40°C-70°C to dissolve the oil in the coix seed cells.

[0027] D. Subsequent processing: After the extraction is completed, the coix seed oil is obtained through filtration and concentration.

[0028] Preferably, the wet granulation mainly comprises the following steps:

[0029] Pour the weighed solid raw materials such as ginseng, fermented pomegranate extract, red date polysaccharide, nelumbo nucifera alkaloids, polygonatum polyphenols, donkey-hide gelatin peptide, theaflavins into the mixing equipment and mix them thoroughly. The mixing time is generally 15-30 minutes to ensure uniform distribution of the ingredients.

[0030] Slowly add coix seed oil to the mixed solid material and continue mixing for a period of time to evenly coat the coix seed oil on the surface of the solid particles to prevent them from agglomerating;

[0031] Under stirring, slowly add the auxiliary adhesive to the mixed material while stirring, so that the material forms a soft material with a certain viscosity and plasticity;

[0032] The soft material is put into the granulation equipment and made into granules through the screen;

[0033] Spread the prepared wet granules evenly on a drying plate or drying equipment for drying at a temperature between 40-60°C for 2-6 hours;

[0034] The dried granules are added to the granulation equipment for granulation to make the granule size more uniform; the granules after granulation and the auxiliary lubricant are placed in the mixing equipment for total mixing. The total mixing time is 5-10 minutes to obtain the desired prepared granules.

[0035] Preferably, the fluidized bed coating technology mainly includes the following steps:

[0036] Slowly add the prepared particles into the material container of the fluidized bed, controlling the feeding speed and feeding amount so that the material volume occupies half of the fluidized bed volume;

[0037] Start the air conveying system of the fluidized bed to make the material form a fluidized state in the bed layer. By adjusting the air flow and pressure, the material bed layer reaches a stable fluidized state;

[0038] When the material is in a stable fluidized state, the coating liquid is evenly sprayed onto the surface of the fluidized material through a spray gun;

[0039] While spraying the coating liquid, the material is dried at a temperature of 30-80°C;

[0040] After the coating is completed, wait for the material to cool to room temperature, open the discharge port, and discharge the coated material to obtain the desired coated drug.

[0041] Compared with the prior art, the present invention provides a composite preparation with anti-fatigue, tranquilizing, sleep-inducing and anti-aging functions and its preparation method, which has the following beneficial effects:

[0042] 1. This composite preparation has the functions of anti-fatigue, tranquilizing the mind, aiding sleep and anti-aging, and its preparation method. The ginseng in the main medicine greatly replenishes the vital energy, and the red dates strengthen the spleen and nourish the blood, which together have the effect of replenishing qi and producing blood;

[0043] 2. This compound preparation has the functions of anti-fatigue, tranquilizing the mind, aiding sleep and anti-aging, and its preparation method. The polygonatum odoratum in the auxiliary medicine nourishes yin and moistens the lungs, while donkey-hide gelatin replenishes blood and nourishes yin, thereby strengthening the dual replenishment of qi and blood.

[0044] 3. This composite preparation, which has anti-fatigue, tranquilizing, sleep-inducing and anti-aging functions, and its preparation method, uses lotus seeds to soothe the mind and calm the nerves, coix seeds to eliminate dampness and strengthen the spleen, and pomegranates to resist oxidation, forming a synergistic system that "tonifies without stagnation."

[0045] 4. This compound preparation, which has anti-fatigue, calming, sleep-inducing and anti-aging functions, and its preparation method, enhances the antioxidant pathway by adding theaflavins, and probiotics regulate the gut-brain axis and improve sleep rhythm;

[0046] The parts not mentioned in this device are the same as the existing technology or can be implemented by using the existing technology. The present invention scientifically combines probiotics with classic tonic Chinese medicines, breaks through the bottleneck of component interaction through the "microorganism-traditional Chinese medicine" co-fermentation technology, and establishes a three-level action model of "Qi and blood harmonization-viscera balance-cell repair" to meet the needs of modern medicine for functional preparations. DETAILED DESCRIPTION

[0047] The technical solutions in the embodiments of the present invention will be described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments.

[0048] Example 1:

[0049] A compound preparation with anti-fatigue, calming, sleep-inducing and anti-aging functions, mainly comprising the following raw materials: ginseng; fermented pomegranate extract; red date polysaccharide; lotus seed core base; coix seed oil; polygonatum polyphenols; donkey-hide gelatin peptide; theaflavins; compound probiotics;

[0050] It should be noted that ginseng needs to be cultivated for more than five years to ensure the stability of saponin content;

[0051] The present invention adopts the combination of monarch drug, ministerial drug and adjuvant drug, wherein:

[0052] The ginseng in the main medicine greatly replenishes the vital energy, and the red dates strengthen the spleen and nourish the blood, which together have the effect of replenishing the qi and producing blood;

[0053] The Huangjing in the auxiliary medicine nourishes yin and moistens the lungs, while the donkey-hide gelatin replenishes blood and nourishes yin, strengthening both qi and blood;

[0054] The lotus seeds in the adjuvants soothe the mind and calm the spirit, the coix seeds eliminate dampness and strengthen the spleen, and the pomegranates are antioxidants, forming a synergistic system that "tonifies without stagnation";

[0055] At the same time, theaflavins are added to enhance antioxidant pathways, and probiotics regulate the gut-brain axis and improve sleep rhythms;

[0056] The ginseng added in this application has the effects of greatly replenishing vital energy, restoring pulse and strengthening deficiency, nourishing spleen and lung, promoting fluid and nourishing blood, calming the mind and improving intelligence, and warming the middle and strengthening the spleen;

[0057] The jujube added in this application is a blood-enriching agent, mainly to improve the body's ability to use blood.

[0058] The lotus seeds added in this application nourish the spleen and stop diarrhea, benefit the kidneys and astringe the essence, nourish the heart and calm the mind, and are used for long-term diarrhea due to spleen deficiency, spermatorrhea, leukorrhea, palpitations and insomnia.

[0059] The coix seed added in the present application has the effects of promoting water and dampness dissipation, strengthening the spleen and stopping diarrhea, removing numbness, discharging pus, and detoxifying and dispersing stagnation.

[0060] The pomegranate seeds added in this application can increase the permeability of capillaries and nourish the skin.

[0061] The polygonatum added in this application replenishes qi and nourishes yin, strengthens the spleen and benefits the kidneys.

[0062] The donkey-hide gelatin added in this application has the effects of nourishing blood, stopping bleeding, nourishing yin and moistening dryness, etc.

[0063] This invention scientifically combines probiotics with classic tonic Chinese medicines, breaks through the bottleneck of component interaction through the "microorganism-traditional Chinese medicine" co-fermentation technology, and establishes a three-level action model of "qi and blood harmonization-viscera balance-cell repair" to meet the needs of modern medicine for functional preparations.

[0064] Example 2:

[0065] A compound preparation with anti-fatigue, tranquilizing, sleep-inducing and anti-aging functions, comprising the following raw material components: ginseng: 15-25%; fermented pomegranate extract: 10-18%; red date polysaccharide: 8-12%; nelumbo nucifera pine: 5-10%; coix seed oil: 3-8%; polygonatum polyphenols: 5-10%; donkey-hide gelatin peptide: 8-15%; theaflavins: 2-5%; and compound probiotics: 1-3%.

[0066] Furthermore, the content ratio of each raw material component is as follows: ginseng: 20%; fermented pomegranate extract: 15%; red date polysaccharide: 10%; nelumbo nucifera alkaloids: 8%; coix seed oil: 5%; polygonatum polyphenols: 8%; donkey-hide gelatin peptide: 12%; theaflavins: 3%; compound probiotics: 2%;

[0067] The present invention adopts the combination of monarch drug, ministerial drug and adjuvant drug, wherein:

[0068] The ginseng in the main medicine greatly replenishes the vital energy, and the red dates strengthen the spleen and nourish the blood, which together have the effect of replenishing the qi and producing blood;

[0069] The Huangjing in the auxiliary medicine nourishes yin and moistens the lungs, while the donkey-hide gelatin replenishes blood and nourishes yin, strengthening both qi and blood;

[0070] The lotus seeds in the adjuvants soothe the mind and calm the spirit, the coix seeds eliminate dampness and strengthen the spleen, and the pomegranates are antioxidants, forming a synergistic system that "tonifies without stagnation";

[0071] At the same time, theaflavins are added to enhance antioxidant pathways, and probiotics regulate the gut-brain axis and improve sleep rhythms;

[0072] This invention scientifically combines probiotics with classic tonic Chinese medicines, breaks through the bottleneck of component interaction through the "microorganism-traditional Chinese medicine" co-fermentation technology, and establishes a three-level action model of "qi and blood harmonization-viscera balance-cell repair" to meet the needs of modern medicine for functional preparations.

[0073] Example 3:

[0074] A method for preparing a composite preparation having anti-fatigue, tranquilizing, sleep-inducing and anti-aging functions mainly comprises the following steps:

[0075] S1. Extracting saponin components from ginseng and retaining saponin activity. Ultrasonic-assisted extraction can retain the activity of saponin.

[0076] During the extraction of saponins, the ginseng is dried and then crushed into a powder; an ethanol solvent is selected and mixed with the crushed ginseng, and the mixture is placed in an ultrasonic device. The ultrasonic parameters are set to a power of 200W to 500W, a sonication time of 10 to 30 minutes, and an extraction temperature of 30°C to 60°C to accelerate the rupture of ginseng cells and allow the obtained saponins to be quickly dissolved into the solvent; after the extraction is completed, the desired saponins are obtained through filtration, concentration, and purification.

[0077] S2. fermenting pomegranate with lactic acid bacteria to obtain polyphenolic compounds, thereby improving the utilization rate of polyphenolic compounds;

[0078] S3, extracting red date polysaccharides from red dates, extracting nelumbo nucifera alkaloids from lotus seeds, extracting coix seed oil from coix seeds, and extracting polygonatum polyphenols from polygonatum;

[0079] When extracting red date polysaccharides, the red dates are dried and then crushed into a powder; deionized water is selected and mixed with the crushed ginseng, and the mixture is placed in an ultrasonic device, and ultrasonic parameters are set, with an ultrasonic power between 200W and 500W, an ultrasonic time of 10 minutes to 30 minutes, and an extraction temperature controlled at 30°C to 60°C to accelerate the rupture of red date cells and allow the obtained red date polysaccharides to be quickly dissolved into a solvent; after the extraction is completed, the desired red date polysaccharides are obtained through filtration, concentration, and purification;

[0080] When extracting nelumbo nucifera, the lotus seed core is dried and then crushed into a powdered state; an ethanol solvent is selected and mixed with the crushed ginseng, and the mixture is placed in an ultrasonic device. Ultrasonic parameters are set, with an ultrasonic power between 200W and 500W, an ultrasonic time between 10 minutes and 30 minutes, and an extraction temperature controlled between 30°C and 60°C to accelerate the rupture of lotus seed core cells and allow the obtained nelumbo nucifera to be quickly dissolved into the solvent; after the extraction is completed, the desired nelumbo nucifera is obtained through filtration, concentration, and purification.

[0081] When extracting coix seed oil, the coix seed is washed, dried and then crushed into powder, an organic solvent ethanol is selected and mixed evenly with the coix seed powder, the mixture is placed in a microwave extraction device, microwave parameters are set, the microwave power is between 300W and 800W, the extraction time is 1 to 5 minutes, and the temperature is controlled at 40°C to 70°C to dissolve the oil in the coix seed cells. After the extraction is completed, the coix seed oil is obtained by filtering and concentrating.

[0082] When extracting polygonatum polyphenol, polygonatum is dried and then crushed into powder; an ethanol solvent is selected and mixed with the crushed ginseng, and the mixture is placed in an ultrasonic device, and ultrasonic parameters are set, with an ultrasonic power between 200W and 500W, an ultrasonic time between 10 minutes and 30 minutes, and an extraction temperature controlled between 30°C and 60°C, so as to accelerate the rupture of polygonatum cells and allow the obtained polygonatum polyphenol to be quickly dissolved into the solvent; after the extraction is completed, the desired polygonatum polyphenol is obtained through filtration, concentration, and purification;

[0083] S4, take 20% ginseng, 15% fermented pomegranate extract, 10% red date polysaccharide, 8% lotus seed heart core, 5% coix seed oil, 8% polygonatum polyphenols, 12% donkey-hide gelatin peptide, and add 3% theaflavins and 2% probiotics;

[0084] Pour the weighed solid raw materials such as ginseng, fermented pomegranate extract, red date polysaccharide, nelumbo nucifera alkaloids, polygonatum polyphenols, donkey-hide gelatin peptide, theaflavins into the mixing equipment and mix them thoroughly. The mixing time is generally 15-30 minutes to ensure uniform distribution of the ingredients.

[0085] Slowly add coix seed oil to the mixed solid material and continue mixing for a period of time to evenly coat the coix seed oil on the surface of the solid particles to prevent them from agglomerating;

[0086] Under stirring, slowly add the auxiliary adhesive to the mixed material while stirring, so that the material forms a soft material with a certain viscosity and plasticity;

[0087] The soft material is put into the granulation equipment and made into granules through the screen;

[0088] Spread the prepared wet granules evenly on a drying plate or drying equipment for drying at a temperature between 40-60°C for 2-6 hours;

[0089] The dried granules are added to a granulation device for granulation to make the granule size more uniform; the granules after granulation and auxiliary lubricant are placed in a mixing device for total mixing for 5-10 minutes to obtain the desired granules;

[0090] Slowly add the prepared particles into the material container of the fluidized bed, controlling the feeding speed and feeding amount so that the material volume occupies half of the fluidized bed volume;

[0091] Start the air conveying system of the fluidized bed to make the material form a fluidized state in the bed layer. By adjusting the air flow and pressure, the material bed layer reaches a stable fluidized state;

[0092] When the material is in a stable fluidized state, the coating liquid is evenly sprayed onto the surface of the fluidized material through a spray gun;

[0093] While spraying the coating liquid, the material is dried at a temperature of 30-80°C;

[0094] After the coating is completed, wait for the material to cool to room temperature, open the discharge port, and discharge the coated material to obtain the desired coated drug;

[0095] This invention scientifically combines probiotics with classic tonic Chinese medicines, breaks through the bottleneck of component interaction through the "microorganism-traditional Chinese medicine" co-fermentation technology, and establishes a three-level action model of "qi and blood harmonization-viscera balance-cell repair" to meet the needs of modern medicine for functional preparations.

[0096] Comparative Example 1:

[0097] The drug prepared in Example 3 was selected, and two mice with similar parameters were prepared. One of the mice was fed with the drug prepared in Example 3, and the other was fed with other drugs of similar quality.

[0098] Two mice were asked to swim with the same weight. The results showed that the weighted swimming time of the mice was prolonged by 58%, the GABA level in the brain increased by 42%, and the collagen synthesis in the skin increased by 35%.

[0099] The present invention can improve the absorption of product ingredients through the triple mechanism of replenishing qi and nourishing blood to improve energy metabolism, regulating neurotransmitter balance, and scavenging free radicals. The medicine and food homologous matrix is combined with probiotics, and toxicology tests show that LD50 is greater than 15g / kg.

[0100] The above description is only a preferred specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any technician familiar with the technical field, within the technical scope disclosed by the present invention, who makes equivalent replacements or changes based on the technical solution and inventive concept of the present invention, should be covered by the scope of protection of the present invention.

Claims

1. A composite preparation with anti-fatigue, tranquilizing, sleep-inducing and anti-aging functions, characterized in that: Mainly contains the following raw materials: Ginseng; fermented pomegranate extract; Red date polysaccharides; Nelumboside; Job's tears oil; Polygonatum sibiricum polyphenols; donkey-hide gelatin peptide; theaflavins; Complex probiotics.

2. The composite preparation with anti-fatigue, tranquilizing, sleep-inducing and anti-aging functions according to claim 1, characterized in that: The content ratio of each raw material component is: Ginseng: 15-25%; Fermented pomegranate extract: 10-18%; Red date polysaccharides: 8-12%; Nelumboside: 5-10%; Job's tears oil: 3-8%; Polygonatum sibiricum polyphenols: 5-10%; Donkey-hide gelatin peptide: 8-15%; Theaflavins: 2-5%; Complex probiotics: 1-3%.

3. The composite preparation with anti-fatigue, tranquilizing, sleep-inducing and anti-aging functions according to claim 2, characterized in that: The content ratio of each raw material component is: Ginseng: 20%; Fermented pomegranate extract: 15%; Red date polysaccharide: 10%; Nelumboside: 8%; Job's tears oil: 5%; Polygonatum sibiricum polyphenols: 8%; Donkey-hide gelatin peptide: 12%; Theaflavins: 3%; Complex probiotics: 2%.

4. The composite preparation having anti-fatigue, tranquilizing, sleep-inducing and anti-aging functions according to any one of claims 1 to 3, characterized in that: The composite probiotics are composed of lactobacillus and bifidobacterium in a 1:1 ratio.

5. A method for preparing the composite preparation having anti-fatigue, tranquilizing, sleep-inducing and anti-aging functions as claimed in claim 4, characterized in that: It mainly includes the following steps: S1. Extract saponin components from ginseng and retain saponin activity; S2, fermenting the pomegranate with lactic acid bacteria to obtain polyphenolic compounds; S3, extracting red date polysaccharides from red dates, extracting nelumbo nucifera alkaloids from lotus seeds, extracting coix seed oil from coix seeds, and extracting polygonatum polyphenols from polygonatum; S4. Take 20% ginseng, 15% fermented pomegranate extract, 10% red date polysaccharide, 8% nelumbo nucifera alkaloids, 5% coix seed oil, 8% polygonatum polyphenols, 12% donkey-hide gelatin peptide, add 3% theaflavins and 2% probiotics, and use fluidized bed coating technology to form after wet granulation.

6. The method for preparing the composite preparation having anti-fatigue, tranquilizing, sleep-inducing and anti-aging functions according to claim 5, characterized in that: In steps S1 and S3, saponins from ginseng, jujube polysaccharides from red dates, nelumbo nucifera from lotus seeds, and polygonatum polyphenols from polygonatum are extracted by ultrasonic-assisted extraction. The ultrasonic-assisted extraction method mainly comprises the following steps: a. Pre-treating the raw materials: drying the ginseng, red dates, lotus seed core or polygonatum, and crushing the raw materials into powder after drying; b. Select a suitable solvent; c. Ultrasonic extraction: Mix the raw material powder with the selected solvent and place it in an ultrasonic device; Set the ultrasonic parameters, ultrasonic power between 200W-500W, ultrasonic time between 10 minutes and 30 minutes, and extraction temperature between 30℃-60℃ to accelerate the rupture of raw material cells and allow the obtained substance to be quickly dissolved into the solvent; d. After the extraction is completed, the desired extract is obtained through filtration, concentration and purification.

7. The method for preparing the composite preparation having anti-fatigue, tranquilizing, sleep-inducing and anti-aging functions according to claim 6, characterized in that: In the step b, the solvent selected for extracting saponins, nelumboside and polygonatum polyphenols is ethanol, and the solvent selected for extracting red date polysaccharides is deionized water.

8. The method for preparing the composite preparation having anti-fatigue, tranquilizing, sleep-inducing and anti-aging functions according to claim 5, characterized in that: In step S3, the coix seed oil is extracted from the coix seed by microwave-assisted extraction; The microwave-assisted extraction method mainly comprises the following steps: A. Raw material processing: Wash and dry the coix seeds and then grind them into powder. B. Solvent selection and mixing: Use organic solvent ethanol and mix it evenly with coix seed powder. C. Microwave extraction: Place the mixture into a microwave extraction device, set the microwave parameters, microwave power between 300W-800W, extraction time between 1-5 minutes, and temperature between 40°C-70°C to dissolve the oil in the coix seed cells. D. Subsequent processing: After the extraction is completed, the coix seed oil is obtained through filtration and concentration.

9. The method for preparing the composite preparation having anti-fatigue, tranquilizing, sleep-inducing and anti-aging functions according to claim 5, characterized in that: The wet granulation mainly comprises the following steps: Pour the weighed solid raw materials such as ginseng, fermented pomegranate extract, red date polysaccharide, nelumbo nucifera alkaloids, polygonatum polyphenols, donkey-hide gelatin peptide, theaflavins into the mixing equipment and mix them thoroughly. The mixing time is generally 15-30 minutes to ensure uniform distribution of the ingredients. Slowly add coix seed oil to the mixed solid material and continue mixing for a period of time to evenly coat the coix seed oil on the surface of the solid particles to prevent them from agglomerating; Under stirring, slowly add the auxiliary adhesive to the mixed material while stirring, so that the material forms a soft material with a certain viscosity and plasticity; The soft material is put into the granulation equipment and made into granules through the screen; Spread the prepared wet granules evenly on a drying plate or drying equipment for drying at a temperature between 40-60°C for 2-6 hours; The dried granules are added to the granulation equipment for granulation to make the granule size more uniform; the granules after granulation and the auxiliary lubricant are placed in the mixing equipment for total mixing. The total mixing time is 5-10 minutes to obtain the desired prepared granules.

10. The method for preparing the composite preparation having anti-fatigue, tranquilizing, sleep-inducing and anti-aging functions according to claim 9, characterized in that: The fluidized bed coating technology mainly includes the following steps: Slowly add the prepared particles into the material container of the fluidized bed, controlling the feeding speed and feeding amount so that the material volume occupies half of the fluidized bed volume; Start the air conveying system of the fluidized bed to make the material form a fluidized state in the bed layer. By adjusting the air flow and pressure, the material bed layer reaches a stable fluidized state; When the material is in a stable fluidized state, the coating liquid is evenly sprayed onto the surface of the fluidized material through a spray gun; While spraying the coating liquid, the material is dried at a temperature of 30-80°C; After the coating is completed, wait for the material to cool to room temperature, open the discharge port, and discharge the coated material to obtain the desired coated drug.