Auxiliary quantifying device for gas chromatograph-mass spectrometer

Abstract

According to the auxiliary quantifying device for the gas chromatograph-mass spectrometer, a rotary valve body is arranged between a sample introduction end body and a mass spectrum end body, the communication states of a sample introduction channel, a carrier gas channel, a quantifying channel and a straight-through channel can be switched by rotating the rotary valve body, and then a quantifying flow path or a straight-through flow path is formed; compared with an external standard method which is easy to be influenced by instrument fluctuation due to long test interval time, the method has the advantage that the accuracy of quantitative analysis is greatly improved; meanwhile, an internal standard substance does not need to be added into each sample like an internal standard method, so that the difficulty that the weighing of the internal standard substance needs to be highly accurate and a proper internal standard substance is found is avoided, and the experiment cost and workload are reduced; in addition, the sample injection mode is flexible, the quantitative flow path meets the requirement for accurate sample injection, the straight-through flow path achieves rapid sample injection and can adapt to different scenes, the practicability and applicability of the device are enhanced, and the defects of an existing external standard method and an existing internal standard method in the aspects of interference resistance, operation efficiency, cost control and the like are effectively overcome.

Description

Technical Field

[0001] The present application generally relates to the field of mass spectrometry quantitative technology, and specifically relates to an auxiliary quantitative device for gas chromatography-mass spectrometry (GC-MS). Background Art

[0002] In the field of chemical composition analysis, gas chromatography-mass spectrometry combines gas chromatography with mass spectrometry. The mixture of components is vaporized and separated by gas chromatography, and the components enter the mass spectrometer in order of retention time. The gas molecules of each component are ionized in the ion source to generate positively charged ions with different mass-to-charge ratios. The ion beam is formed by the action of the accelerating electric field. After entering the mass analyzer, it is separated according to the size of the mass-to-charge ratio. Finally, the detector detects the electrical signal converted from the ion beam flow, and performs detection and processing to obtain chromatograms, mass spectra and other information.

[0003] At present, the quantitative analysis of gas chromatographs often adopts the external standard method or the internal standard method; among them: the external standard method draws a standard curve by drawing a standard sample of different concentrations to infer the concentration of the component to be measured. However, this method has a long test interval between the standard sample and the sample to be measured, and has strict requirements on experimental conditions. It is easily affected by changes in the instrument operating environment, charge accumulation in ion optics, and changes in lens parameters caused by instrument instability. Even a small fluctuation of the instrument may cause deviations in the analysis results, resulting in a decrease in the quantitative accuracy of the sample to be measured; while the internal standard method requires the addition of an internal standard to each sample, which not only increases the experimental cost and workload, but also requires a high degree of accuracy in weighing the internal standard, and the operation is highly complex. At the same time, it is also difficult to find a suitable internal standard. In summary, the existing external standard method and internal standard method have inherent defects in terms of anti-interference, operating efficiency and cost control, and it is difficult to meet the needs of high-precision, high-throughput quantitative analysis. Summary of the Invention

[0004] In view of the above-mentioned defects or deficiencies in the prior art, it is desired to provide an auxiliary quantitative device for gas chromatography-mass spectrometry that can solve the above-mentioned technical problems.

[0005] The present application provides an auxiliary quantitative device for gas chromatography-mass spectrometry, comprising: An injection end body, wherein an injection channel and a carrier gas channel are respectively provided through the injection end body along the first axis direction; the injection channel is used to introduce a standard sample, and the carrier gas channel is used to introduce a carrier gas; A mass spectrometer end body, the mass spectrometer end body being arranged on one side of the injection end body along the first axis, the mass spectrometer end body being respectively provided with a first output channel and a second output channel along the first axis, the first output channel being coaxially arranged with the injection channel, and the second output channel being coaxially arranged with the carrier gas channel; and the other end of the mass spectrometer end body being connected to an ionization chamber; A rotary valve body is rotatably arranged between the injection end body and the mass spectrometer end body, and at least a quantitative channel and a straight-through channel are arranged on the rotary valve body; by rotating the rotary valve body, the connection state between the injection channel, the carrier gas channel and the quantitative channel and the straight-through channel can be switched, thereby forming a quantitative flow path or a straight-through flow path; the quantitative flow path is used to allow the standard sample or carrier gas to enter the ionization chamber in precise quantity; the straight-through flow path is used to allow the standard sample or carrier gas to enter the ionization chamber directly.

[0006] According to the technical solution provided in the present application, the quantitative channel includes a first quantitative sub-channel and a second quantitative sub-channel, the first quantitative sub-channel is arranged close to the injection end body, and the second quantitative sub-channel is arranged close to the mass spectrometry end body; the first quantitative sub-channel is coaxial with the second quantitative sub-channel but not connected; a quantitative component is provided on the rotary valve body, and the quantitative component is respectively connected to the first quantitative sub-channel and the second quantitative sub-channel, and the quantitative component is used to control the standard sample or carrier gas to enter the ionization chamber in precise amounts.

[0007] According to the technical solution provided in the present application, the quantitative component includes: a first mounting hole and a second mounting hole arranged on the rotary valve body, the first mounting hole is connected to the first quantitative sub-channel, the second mounting hole is connected to the second quantitative sub-channel, and a quantitative ring is arranged between the first mounting hole and the second mounting hole.

[0008] According to the technical solution provided in the present application, a first angle is formed between the line connecting the center of the injection channel and the center of the injection end body, and the line connecting the center of the carrier gas channel and the center of the injection end body; a second angle is formed between the line connecting the center of the quantitative channel and the center of the rotary valve body, and the center of the straight-through channel and the rotary valve body; the second angle is twice the first angle.

[0009] When in the first state, the injection channel is connected to the first quantitative sub-channel, the first output channel is connected to the second quantitative sub-channel, and the carrier gas channel and the second output channel are cut off; when in the second state, the injection channel and the first output channel are cut off, and the carrier gas channel and the second output channel are connected to the straight-through channel; when in the third state, the injection channel and the first output channel are connected to the straight-through channel, and the carrier gas channel and the second output channel are cut off; when in the fourth state, the injection channel, the carrier gas channel, the first output channel, and the second output channel are all cut off; when in the fifth state, the injection channel and the first output channel are cut off, the carrier gas channel is connected to the first quantitative sub-channel, and the second output channel is connected to the second quantitative sub-channel.

[0010] According to the technical solution provided in the present application, a transmission shaft is provided through the centers of the injection end body, the rotary valve body and the mass spectrometry end body along the direction of the first axis. The transmission shaft is fixedly connected to the injection end body and the mass spectrometry end body respectively, and the rotary valve body is rotatably connected to the transmission shaft.

[0011] According to the technical solution provided in the present application, a seal is provided between the injection end body and the rotary valve body, and between the mass spectrometry end body and the rotary valve body.

[0012] According to the technical solution provided in this application, an output port is provided on the side of the mass spectrometer end body away from the rotary valve body, the output port is connected to the first output channel and the second output channel, and the output port is used to connect to the ionization chamber.

[0013] The beneficial effects of this application are: The present application provides an auxiliary quantitative device for a gas chromatography-mass spectrometer. The present application provides a rotary valve body between the injection end body and the mass spectrometer end body. By rotating the rotary valve body, the connection state of the injection channel, the carrier gas channel, the quantitative channel and the straight-through channel is switched, thereby forming a quantitative flow path or a straight-through flow path; the quantitative flow path allows the standard sample to enter the ionization chamber in an accurate amount, effectively shortening the analysis time difference between the standard sample and the sample to be tested, and significantly eliminating the interference of factors such as changes in the instrument operating environment, ion optical charge accumulation, and changes in lens parameters caused by instrument instability on quantitative analysis. Compared with the external standard method, which is easily affected by instrument fluctuations due to the long test interval, the accuracy is inaccurate. The defect of decreased accuracy is eliminated, which greatly improves the accuracy of quantitative analysis; at the same time, there is no need to add internal standard to each sample as in the internal standard method, which avoids the need for highly accurate weighing of internal standards and the difficulty of finding suitable internal standards, reduces experimental costs and workload, and simplifies the operating process; in addition, the design of the rotary valve body switching flow path makes the injection mode flexible, the quantitative flow path meets the needs of precise injection, and the straight-through flow path achieves fast injection, which can adapt to different scenarios, enhances the practicality and applicability of the device, and effectively solves the inherent defects of the existing external standard method and internal standard method in anti-interference, operating efficiency and cost control, and can better meet the needs of high-precision and high-throughput quantitative analysis. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] Other features, objects and advantages of the present application will become more apparent upon reading the detailed description of non-limiting embodiments made with reference to the following drawings: Figure 1 This is a schematic diagram of an auxiliary quantitative device for gas chromatography-mass spectrometry provided by the present application; Figure 2 This is a schematic diagram of an auxiliary quantitative device for gas chromatography-mass spectrometry provided by the present application; Figure 3This is an exploded view of an auxiliary quantitative device for gas chromatography-mass spectrometry provided by the present application; Figure 4 This is an exploded diagram on the left side of an auxiliary quantitative device for gas chromatography-mass spectrometry provided by the present application; Figure 5 This is an exploded view on the right side of an auxiliary quantitative device for gas chromatography-mass spectrometry provided by the present application.

[0015] In the figure: 1. Injection end body; 2. Injection channel; 3. Carrier gas channel; 4. Mass spectrometer end body; 5. Rotary valve body; 6. First quantitative sub-channel; 7. Second quantitative sub-channel; 8. Straight-through channel; 9. First mounting hole; 10. Second mounting hole; 11. Quantitative ring; 12. Drive shaft; 13. Output port; 14. First output channel; 15. Second output channel. DETAILED DESCRIPTION

[0016] The present application will be further described in detail below with reference to the accompanying drawings and examples. It should be understood that the specific embodiments described herein are merely for the purpose of explaining the relevant invention and are not intended to limit the invention. It should also be noted that, for ease of description, only portions relevant to the invention are shown in the accompanying drawings.

[0017] It should be noted that, in the absence of conflict, the embodiments and features of the embodiments in this application can be combined with each other. The present application will be described in detail below with reference to the accompanying drawings and in combination with the embodiments.

[0018] Example 1 Please refer to Figure 1-Figure 5 The present application provides an auxiliary quantitative device for gas chromatography-mass spectrometry, comprising: The injection end body 1 has an injection channel 2 and a carrier gas channel 3 respectively extending along the first axis. The injection channel 2 is used to introduce a standard sample, and the carrier gas channel 3 is used to introduce a carrier gas. The carrier gas plays a key role in carrying the sample and maintaining the flow path stability during the analysis process. The mass spectrometer end body 4 is arranged on one side of the injection end body 1 along the first axis direction, and is respectively penetrated by a first output channel 14 and a second output channel 15 along the first axis direction. The first output channel 14 is coaxially arranged with the injection channel 2 to ensure that the standard sample can be accurately transmitted from the injection channel 2 to the first output channel 14 of the mass spectrometer end body 4, and then enter the subsequent analysis link; the second output channel 15 is coaxially arranged with the carrier gas channel 3 to allow the carrier gas to smoothly pass through the carrier gas channel 3 into the second output channel 15 of the mass spectrometer end body 4; in addition, the other end of the mass spectrometer end body 4 is connected to the ionization chamber, which is the key place for sample ionization. The standard sample and the carrier gas undergo an ionization process here, laying the foundation for mass spectrometry analysis; The rotary valve body 5 is rotatably arranged between the injection end body 1 and the mass spectrometry end body 4, and at least a quantitative channel and a straight-through channel 8 are arranged on the rotary valve body 5; by rotating the rotary valve body 5, the connection state between the injection channel 2, the carrier gas channel 3 and the quantitative channel and the straight-through channel 8 can be flexibly switched, thereby forming a quantitative flow path or a straight-through flow path; the quantitative flow path is used to allow the standard sample to enter the ionization chamber in precise quantity. This precise quantity control is crucial for quantitative analysis, and can ensure that the amount of sample or carrier gas entering the ionization chamber each time is consistent, thereby improving the accuracy and repeatability of the analysis results; the straight-through flow path is used to allow the standard sample or carrier gas to directly enter the ionization chamber. In analysis scenarios with high time requirements, it can meet the needs of rapid injection and improve analysis efficiency.

[0019] Specifically, such as Figure 1 As shown, in the figure: a is the direction of the first axis; Working principle: By rotating the rotary valve body 5, the present application can switch the connection state of the injection channel 2, the carrier gas channel 3 and the quantitative channel and the straight-through channel 8, thereby forming a quantitative flow path or a straight-through flow path; the quantitative flow path can allow the standard sample or carrier gas to enter the ionization chamber in precise amounts, effectively shortening the analysis time difference between the standard sample and the sample to be tested, and significantly eliminating the interference of factors such as changes in the instrument operating environment, ion optical charge accumulation, and changes in lens parameters caused by instrument instability on quantitative analysis. Compared with the external standard method, which is susceptible to instrument fluctuations due to long test intervals and thus has a reduced accuracy, the quantitative analysis is greatly improved. Accuracy; at the same time, there is no need to add an internal standard to each sample as in the internal standard method, which avoids the need for highly accurate weighing of the internal standard and the difficulty in finding a suitable internal standard, reduces experimental costs and workload, and simplifies the operating process; in addition, the design of the rotary valve body 5 switching flow path makes the injection mode flexible, the quantitative flow path meets the needs of precise injection, and the straight-through flow path achieves fast injection, which can adapt to different scenarios, enhances the practicality and applicability of the device, and effectively solves the inherent defects of the existing external standard method and internal standard method in terms of anti-interference, operating efficiency and cost control, and can better meet the needs of high-precision, high-throughput quantitative analysis.

[0020] In some embodiments, the quantitative channel includes a first quantitative sub-channel 6 and a second quantitative sub-channel 7, the first quantitative sub-channel 6 is arranged close to the injection end body 1, and the second quantitative sub-channel 7 is arranged close to the mass spectrometry end body 4; the first quantitative sub-channel 6 and the second quantitative sub-channel 7 are coaxial but not connected; a quantitative component is provided on the rotary valve body 5, and the quantitative component is respectively connected to the first quantitative sub-channel 6 and the second quantitative sub-channel 7, and the quantitative component is used to control the standard sample or carrier gas to enter the ionization chamber in precise amounts.

[0021] Specifically, the quantitative channel includes a first quantitative sub-channel 6 and a second quantitative sub-channel 7; wherein the first quantitative sub-channel 6 is arranged near the injection end body 1, and its inlet is connected to the injection channel 2 or the carrier gas channel 3, for receiving the standard sample or carrier gas; the second quantitative sub-channel 7 is arranged near the mass spectrometer end body 4, and its outlet is connected to the first output channel 14 or the second output channel 15, providing a channel for the standard sample or carrier gas to enter the ionization chamber; and the first quantitative sub-channel 6 and the second quantitative sub-channel 7 are coaxial but not connected, and the two are connected by the quantitative component on the rotary valve body 5; Specifically, the quantitative component is connected to the first quantitative sub-channel 6 and the second quantitative sub-channel 7 respectively; by rotating the rotary valve body 5, the first quantitative sub-channel 6 is connected to the injection channel 2, and the standard sample enters the quantitative component from the injection channel 2 and is filled to a preset precise amount; then, the first quantitative sub-channel 6 is connected to the carrier gas channel 3, and at this time the second quantitative sub-channel 7 is connected to the second output channel 15, and the carrier gas enters the quantitative component from the carrier gas channel 3 to transfer the standard sample in the quantitative component to the ionization chamber; this design ensures that the standard sample entering the ionization chamber each time is a precise amount, effectively avoiding analysis errors caused by fluctuations in the injection volume, and improving the accuracy and reliability of quantitative analysis.

[0022] In some embodiments, the quantitative component includes: a first mounting hole 9 and a second mounting hole 10 arranged on the rotary valve body 5, the first mounting hole 9 is connected to the first quantitative sub-channel 6, the second mounting hole 10 is connected to the second quantitative sub-channel 7, and a quantitative ring 11 is arranged between the first mounting hole 9 and the second mounting hole 10.

[0023] Specifically, such as Figure 4 As shown, the quantitative component includes a first mounting hole 9 and a second mounting hole 10 provided on the rotary valve body 5; wherein the first mounting hole 9 is connected to the first quantitative sub-channel 6, serving as an inlet for the standard sample or carrier gas to enter the quantitative component, ensuring that the substance can be smoothly introduced from the first quantitative sub-channel 6; the second mounting hole 10 is connected to the second quantitative sub-channel 7, serving as an outlet for the standard sample or carrier gas to flow out of the quantitative component and into the mass spectrometer end body 4; a quantitative ring 11 is provided between the first mounting hole 9 and the second mounting hole 10, which is a core component for achieving precise quantitative measurement, has a fixed volume, and can store an accurate amount of standard sample or carrier gas; and the quantitative ring 11 is detachably mounted, which is convenient for replacing different capacity specifications according to different quantitative requirements to adapt to diverse analysis scenarios; Specifically, the rotary valve body 5 is rotated, the first quantitative sub-channel 6 is connected to the injection channel 2, and the standard sample enters the quantitative ring 11 from the injection channel 2 and is filled to a preset precise amount; then, the first quantitative sub-channel 6 is connected to the carrier gas channel 3, and at this time the second quantitative sub-channel 7 is connected to the second output channel 15, and the carrier gas enters the quantitative ring 11 from the carrier gas channel 3 to transfer the standard sample in the quantitative ring 11 to the ionization chamber.

[0024] In some embodiments, a first angle is formed between a line connecting the center of the injection channel 2 and the center of the injection end body 1, and a line connecting the center of the carrier gas channel 3 and the center of the injection end body 1; a second angle is formed between a line connecting the center of the quantitative channel and the center of the rotary valve body 5, and a line connecting the center of the straight-through channel 8 and the rotary valve body 5; and the second angle is twice the first angle.

[0025] Specifically, due to the specific multiple relationship between the second angle and the first angle, the flow path alignment accuracy of each switch is guaranteed, preventing flow path misalignment or leakage caused by angle deviation, ensuring that the standard sample or carrier gas accurately enters the ionization chamber according to the preset flow path (quantitative flow path or straight-through flow path), improving the stability and reliability of the auxiliary quantitative device, and laying a solid foundation for the precise analysis of the gas chromatography-mass spectrometer.

[0026] In some embodiments, the rotary valve body 5 has a first state, a second state, a third state, a fourth state and a fifth state respectively; by rotating the valve body 5, the first state, the second state, the third state, the fourth state and the fifth state are switched; When in the first state, the injection channel 2 is connected to the first quantitative sub-channel 6, the first output channel 14 is connected to the second quantitative sub-channel 7, and the carrier gas channel 3 and the second output channel 15 are cut off; when in the second state, the injection channel 2 and the first output channel 14 are cut off, and the carrier gas channel 3 and the second output channel 15 are connected to the straight-through channel 8; when in the third state, the injection channel 2 and the first output channel 14 are connected to the straight-through channel 8, and the carrier gas channel 3 and the second output channel 15 are cut off; when in the fourth state, the injection channel 2, the carrier gas channel 3, the first output channel 14, and the second output channel 15 are all cut off; when in the fifth state, the injection channel 2 and the first output channel 14 are cut off, the carrier gas channel 3 is connected to the first quantitative sub-channel 6, and the second output channel 15 is connected to the second quantitative sub-channel 7.

[0027] Specifically, in the present application, the rotary valve body 5 has a first state, a second state, a third state, a fourth state, and a fifth state. In this embodiment, the first angle is 72 degrees, and the second angle is 144 degrees. That is, in this embodiment, the rotary valve body 5 can switch to a state every time it rotates 72 degrees. Specifically, when the rotary valve body 5 is in the first state, the injection channel 2 is connected to the first quantitative sub-channel 6, the first output channel 14 is connected to the second quantitative sub-channel 7, the carrier gas channel 3 and the second output channel 15 are cut off, and the standard sample enters the quantitative ring 11 with a precise amount; then the rotary valve body 5 is rotated 72 degrees clockwise to switch to the second state, at which time the injection channel 2 and the first output channel 14 are cut off, the carrier gas channel 3 and the second output channel 15 are connected to the straight-through channel 8, and the carrier gas quickly enters the ionization chamber; then the rotary valve body 5 is rotated 72 degrees clockwise to switch to the third state, at which time the injection channel 2 and the first output channel 14 are connected to the straight-through channel 8, the carrier gas channel 3 and the second output channel 15 is cut off, and the standard sample quickly enters the ionization chamber; then the rotary valve body 5 is continued to be rotated 72 degrees clockwise to switch to the fourth state, at which time the sample injection channel 2, the carrier gas channel 3, the first output channel 14, and the second output channel 15 are all cut off; then the rotary valve body 5 is continued to be rotated 72 degrees clockwise to switch to the fifth state, at which time the sample injection channel 2 and the first output channel 14 are cut off, the carrier gas channel 3 is connected to the first quantitative sub-channel 6, and the second output channel 15 is connected to the second quantitative sub-channel 7, and the carrier gas drives the standard sample in the quantitative ring 11 into the ionization chamber in an accurate amount; generally, under non-experimental circumstances, the rotary valve body 5 is kept in the fourth state to ensure that the standard sample and the carrier gas do not enter the ionization chamber; Specifically, the auxiliary quantitative device provided in this application has two uses, including an instrument calibration mode and an auxiliary quantitative mode; During the instrument calibration operation, the rotary valve body 5 is switched to the third state. At this time, the sample injection channel 2 and the first output channel 14 are connected to the straight-through channel 8, and the carrier gas channel 3 and the second output channel 15 are cut off. The standard sample continues to enter the ionization chamber through the straight-through channel 8. The ionization chamber ionizes the standard sample. At this time, the signal of the standard sample is detected, and the mass spectrometer is automatically calibrated according to the signal. When performing the auxiliary quantitative operation, first, the rotary valve body 5 is switched to the first state, at which time the standard sample continues to flow into the ionization chamber through the quantitative ring 11 until the standard sample fills the quantitative ring 11; the rotary valve body 5 is controlled to switch to the second state, at which time the injection channel 2 and the first output channel 14 are cut off, the quantitative ring 11 is filled with a quantitative standard sample, and the carrier gas enters the ionization chamber from the straight-through channel 8, cleaning the rear channel and the ionization chamber to prevent excess standard sample from affecting the test results; after the cleaning is completed, it is quickly switched to the fourth state, at which time the carrier gas channel 3 and the air inlet channel are both in the cut-off state; then it is switched to the fifth state, at which time the carrier gas channel 3 is connected to the quantitative ring 11, and the carrier gas blows the quantitative standard sample in the quantitative ring 11 into the ionization chamber, and the ionization chamber ionizes the quantitative standard sample to detect the signal of the standard sample; at the same time, the sample to be tested enters the ionization chamber through another flow path, thereby being ionized to detect the signal of the sample to be tested; This auxiliary quantitative operation ensures that the standard sample added each time is quantitative. Therefore, in theory, the signal of the standard sample measured each time is the same. However, due to environmental factors, electrical parameter errors, etc., the signal may be inconsistent. The correction factor is calculated based on the inconsistent signal intensity each time. The correction factor and the measured peak area of ​​the sample to be tested can be used to calibrate the peak area of ​​the sample to be tested, thereby making the quantitative determination more accurate. For example, a total of n standard samples are input into the ionization chamber, generating n needle signals. The first needle is selected as the standard needle, and the standard sample signal of the standard needle is , the sample signal to be tested is ; When calibrating the signal of the second needle to be tested sample, the correction factor of the second needle to be tested sample is Calculate according to formula 1: Formula 1; The signal of the second needle after calibration of the sample to be tested Calculate according to formula 2: Formula 2; Similarly, the signal of the sample to be tested at the nth pin is corrected according to Formula 3 and Formula 4: Formula 3; Formula 4; in: is the second needle standard sample signal, is the second pin sample signal to be tested, is the correction factor for the second sample, is the signal after calibration of the second needle sample to be tested, is the standard sample signal of the nth needle, is the sample signal to be tested on the nth pin, is the correction factor for the n-th needle sample, is the signal of the nth needle sample after correction.

[0028] In some embodiments, a transmission shaft 12 is provided through the centers of the injection end body 1, the rotary valve body 5 and the mass spectrometry end body 4 along the first axis direction. The transmission shaft 12 is fixedly connected to the injection end body 1 and the mass spectrometry end body 4 respectively, and the rotary valve body 5 is rotationally connected to the transmission shaft 12.

[0029] Specifically, a transmission shaft 12 is provided through the center of the sampling end body 1, the rotary valve body 5 and the mass spectrometry end body 4 along the first axis direction; the transmission shaft 12 is fixedly connected to the sampling end body 1 and the mass spectrometry end body 4 to ensure that the two bodies maintain a stable relative position during the operation of the device, thereby building a solid structural foundation for the device; the rotary valve body 5 and the transmission shaft 12 are rotationally connected, and this design enables it to rotate flexibly around the transmission shaft 12 to accurately realize the switching of the connection status between the sampling channel 2, the carrier gas channel 3 and the quantitative channel and the straight-through channel 8; this structural design has significant advantages: on the one hand, it ensures the stability and accuracy of the rotation of the rotary valve body 5, effectively avoids flow path dislocation or leakage caused by rotation deviation, and ensures the reliability of the analysis process; on the other hand, it makes the device structure compact and easy to install and debug; at the same time, the rotation connection method is simple and reliable, which reduces manufacturing and maintenance costs, improves the practicality of the device, and ensures that in the quantitative analysis of the gas chromatography-mass spectrometer, various flow path switching functions can be performed stably and accurately, providing a solid guarantee for subsequent precise analysis.

[0030] In some embodiments, a seal is provided between the injection end body 1 and the rotary valve body 5 and between the mass spectrometer end body 4 and the rotary valve body 5 .

[0031] Specifically, seals are provided between the injection end body 1 and the rotary valve body 5, as well as between the mass spectrometry end body 4 and the rotary valve body 5. In this embodiment, the seals are rubber pads, which fit tightly to the contact interfaces between the injection end body 1 and the rotary valve body 5, and between the mass spectrometry end body 4 and the rotary valve body 5, forming a reliable sealing structure to prevent leakage of standard samples and carrier gas during flow path switching, thereby ensuring the independence and stability of each flow path.

[0032] In some embodiments, an output port 13 is provided on a side of the mass spectrometer end body 4 away from the rotary valve body 5 , and the output port 13 is connected to the first output channel 14 and the second output channel 15 , and is used to connect to the ionization chamber.

[0033] Specifically, such as Figure 2As shown, an output port 13 is provided on the side of the mass spectrometer end body 4 away from the rotary valve body 5, and the output port 13 is the key hub for the material to enter the ionization chamber; the output port 13 is directly connected to the first output channel 14 and the second output channel 15 to form a unified transmission path; specifically, when the standard sample is transmitted through the injection channel 2 and the first output channel 14, or when the carrier gas is transmitted through the carrier gas channel 3 and the second output channel 15, they are finally converged through the output port 13 and enter the ionization chamber; this design effectively integrates the material output of the two independent channels, avoids flow path confusion and cross-interference, ensures that the standard sample or carrier gas can enter the ionization chamber stably and orderly, and provides reliable support for subsequent ionization process and mass spectrometry analysis; at the same time, the setting of the output port 13 optimizes the overall structure, enhances the sealing and stability of the connection, reduces the risk of material leakage, improves the accuracy and reliability of the device in the quantitative analysis of the gas chromatography-mass spectrometry, and ensures the efficiency and precision of the analysis process.

[0034] The above description is merely a preferred embodiment of the present application and an illustration of the technical principles employed. Those skilled in the art should understand that the scope of the invention herein is not limited to the technical solutions formed by the specific combination of the above-mentioned technical features, but also encompasses other technical solutions formed by any combination of the above-mentioned technical features or their equivalents without departing from the inventive concept. For example, a technical solution formed by replacing the above-mentioned features with (but not limited to) technical features having similar functions disclosed in this application.

Claims

1. An auxiliary quantitative device for gas chromatography-mass spectrometry, characterized in that: include: An injection end body (1), wherein an injection channel (2) and a carrier gas channel (3) are respectively provided on the injection end body (1) along a first axis direction; the injection channel (2) is used to introduce a standard sample, and the carrier gas channel (3) is used to introduce a carrier gas; A mass spectrometer end body (4), the mass spectrometer end body (4) is arranged on one side of the injection end body (1) along the first axis direction, and is respectively provided with a first output channel (14) and a second output channel (15) along the first axis direction, the first output channel (14) is coaxially arranged with the injection channel (2), and the second output channel (15) is coaxially arranged with the carrier gas channel (3); and the other end of the mass spectrometer end body (4) is connected to an ionization chamber; A rotary valve body (5) is rotatably arranged between the injection end body (1) and the mass spectrometer end body (4), and at least a quantitative channel and a straight-through channel (8) are arranged on the rotary valve body (5); by rotating the rotary valve body (5), the connection state between the injection channel (2), the carrier gas channel (3) and the quantitative channel and the straight-through channel (8) can be switched, thereby forming a quantitative flow path or a straight-through flow path; the quantitative flow path is used to allow the standard sample to enter the ionization chamber in a precise amount; the straight-through flow path is used to allow the standard sample or the carrier gas to enter the ionization chamber directly.

2. The auxiliary quantitative device for gas chromatography-mass spectrometry according to claim 1, characterized in that: The quantitative channel comprises a first quantitative sub-channel (6) and a second quantitative sub-channel (7), wherein the first quantitative sub-channel (6) is arranged close to the injection end body (1), and the second quantitative sub-channel (7) is arranged close to the mass spectrometer end body (4); the first quantitative sub-channel (6) and the second quantitative sub-channel (7) are coaxial but not connected; a quantitative component is arranged on the rotary valve body (5), and the quantitative component is connected to the first quantitative sub-channel (6) and the second quantitative sub-channel (7) respectively, and the quantitative component is used to control the standard sample to enter the ionization chamber in a precise amount.

3. The auxiliary quantitative device for gas chromatography-mass spectrometry according to claim 2, characterized in that: The quantitative assembly comprises: a first mounting hole (9) and a second mounting hole (10) provided on the rotary valve body (5); the first mounting hole (9) is in communication with the first quantitative sub-channel (6); the second mounting hole (10) is in communication with the second quantitative sub-channel (7); and a quantitative ring (11) is provided between the first mounting hole (9) and the second mounting hole (10).

4. The auxiliary quantitative device for gas chromatography-mass spectrometry according to claim 3, characterized in that: A first angle is formed between a line connecting the center of the injection channel (2) and the center of the injection end body (1), and a line connecting the center of the carrier gas channel (3) and the center of the injection end body (1); a second angle is formed between a line connecting the center of the quantitative channel and the center of the rotary valve body (5), and a line connecting the center of the straight-through channel (8) and the rotary valve body (5); and the second angle is twice the first angle.

5. The auxiliary quantitative device for gas chromatography-mass spectrometry according to claim 4, characterized in that: The rotary valve body (5) has a first state, a second state, a third state, a fourth state and a fifth state respectively; by rotating the valve body, the valve body can be switched between the first state, the second state, the third state, the fourth state and the fifth state; When in the first state, the injection channel (2) is connected to the first quantitative sub-channel (6), the first output channel (14) is connected to the second quantitative sub-channel (7), and the carrier gas channel (3) and the second output channel (15) are cut off; when in the second state, the injection channel (2) and the first output channel (14) are cut off, and the carrier gas channel (3) and the second output channel (15) are connected to the straight-through channel (8); when in the third state, the injection channel (2) and the first output channel (14) are connected to the straight-through channel (8), and the carrier gas channel (3) and the second output channel (15) are cut off; when in the fourth state, the injection channel (2), the carrier gas channel (3), the first output channel (14), and the second output channel (15) are all cut off; when in the fifth state, the injection channel (2) and the first output channel (14) are cut off, the carrier gas channel (3) is connected to the first quantitative sub-channel (6), and the second output channel (15) is connected to the second quantitative sub-channel (7).

6. The auxiliary quantitative device for gas chromatography-mass spectrometry according to claim 1, characterized in that: A transmission shaft (12) is provided through the centers of the injection end body (1), the rotary valve body (5) and the mass spectrometer end body (4) along the first axis direction. The transmission shaft (12) is fixedly connected to the injection end body (1) and the mass spectrometer end body (4) respectively, and the rotary valve body (5) is rotationally connected to the transmission shaft (12).

7. The auxiliary quantitative device for gas chromatography-mass spectrometry according to claim 1, characterized in that: Seals are provided between the injection end body (1) and the rotary valve body (5), and between the mass spectrometer end body (4) and the rotary valve body (5).

8. The auxiliary quantitative device for gas chromatography-mass spectrometry according to claim 1, characterized in that: An output port (13) is provided on a side of the mass spectrometer end body (4) away from the rotary valve body (5), the output port (13) being in communication with the first output channel (14) and the second output channel (15), and the output port (13) being used to connect to the ionization chamber.

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