Ultrasonic coupling agent as well as preparation method and application thereof

Abstract

The invention relates to an ultrasonic coupling agent and a preparation method and application thereof. The ultrasonic coupling agent is prepared from the following components in percentage by mass: 10 to 30 parts of glycerol, 0.5 to 3 parts of nano silicon dioxide and 70 to 90 parts of deionized water. Glycerol is colorless, transparent and odorless sticky liquid, and can be matched with acoustic impedance of human tissues, so that the ultrasonic propagation efficiency can be improved. Meanwhile, the gas redissolution time of the ultrasonic coupling agent is longer, the stability is higher, and the interference of bubbles generated after the gas is re-dissolved can be reduced, so that the treatment effect is improved. Meanwhile, the nano silicon dioxide can enable the ultrasonic coupling agent to have a cavitation effect, generation of bubbles in the ultrasonic coupling agent can be further reduced, and the ultrasonic propagation efficiency is further improved. Within the range of the mass parts of all the components of the ultrasonic coupling agent, the ultrasonic coupling agent can improve the ultrasonic propagation efficiency.

Description

Technical Field

[0001] The present application relates to the technical field of ultrasonic coupling agents, and in particular to an ultrasonic coupling agent and a preparation method and application thereof. Background Art

[0002] The surface of human skin is irregular and contains air and oil. Ultrasonic waves are strongly reflected at the air interface between the probe and the skin, resulting in significant energy loss. Ultrasonic coupling fluid fills the gaps on the skin surface, expels air, and reduces sound wave reflection and scattering, allowing ultrasound waves to penetrate the skin and soft tissue smoothly. This improves ultrasound transmission efficiency and enhances the clarity and intensity of the ultrasound signal. Traditional ultrasonic coupling fluids often use degassed water as the coupling medium, but degassed water easily re-dissolves air, creating interfering bubbles and reducing ultrasound transmission efficiency. Summary of the Invention

[0003] Based on this, it is necessary to provide an ultrasonic coupling agent and its preparation method and application. The ultrasonic coupling agent of the present application can improve the efficiency of ultrasonic propagation.

[0004] In a first aspect, the present application provides an ultrasonic coupling agent comprising the following components in the following mass percentages:

[0005] 10 to 30 parts of glycerol, 0.5 to 3 parts of nano-silicon dioxide and 70 to 90 parts of deionized water.

[0006] In some embodiments, the D50 particle size of the nano-silica is 30 nm to 80 nm.

[0007] In some embodiments, the ultrasonic coupling agent further includes 1 to 5 parts by weight of a non-ionic surfactant.

[0008] In some embodiments, the nonionic surfactant includes polyoxyethylene castor oil solution.

[0009] In some embodiments, the mass percentage of polyoxyethylene castor oil in the polyoxyethylene castor oil solution is 8% to 15%.

[0010] In some embodiments, the oxygen content in the ultrasonic coupling agent is less than or equal to 1 mg / L.

[0011] In a second aspect, the present application provides a method for preparing an ultrasonic coupling agent, comprising the following steps:

[0012] The following components are mixed in mass percentage: 10 to 30 parts of glycerol, 0.5 to 3 parts of nano-silicon dioxide, and 70 to 90 parts of deionized water.

[0013] In some embodiments, the steps include:

[0014] Mix 10 to 30 parts by mass of glycerol, 0.5 to 3 parts by mass of nano-silicon dioxide, and 1 to 5 parts by mass of a non-ionic surfactant to obtain a premixed raw material;

[0015] Perform water-gas separation on 70 to 90 parts of deionized water;

[0016] Mixing the premixed raw material and deionized water after water vapor separation to obtain a mixed liquid;

[0017] The mixed liquid is degassed.

[0018] In some embodiments, an ultrasonic coupling agent preparation device is used for preparation, and the ultrasonic coupling agent preparation device includes: a premixing device, a water-gas separation device, a liquid storage device, a mixing device, and a degassing device; the discharge end of the premixing device is connected to the feed end of the mixing device; the discharge end of the water-gas separation device is connected to the feed end of the liquid storage device; the discharge end of the liquid storage device is connected to the feed end of the mixing device; and the discharge end of the mixing device is connected to the feed end of the degassing device; and the steps include:

[0019] Mixing 10 to 30 parts by mass of glycerol, 0.5 to 3 parts by mass of nano-silicon dioxide, and 1 to 5 parts by mass of a non-ionic surfactant in the premixing device to obtain a premixed raw material;

[0020] Using the water-gas separation device to perform water-gas separation treatment on 70 to 90 parts of deionized water, and storing the deionized water after the water-gas separation treatment in the liquid storage device;

[0021] adding the deionized water in the liquid storage device and the premixed raw materials in the premixing device into the mixing device and mixing them to obtain a mixed liquid;

[0022] The mixed liquid is degassed using the degassing device.

[0023] In a third aspect, the present application provides an ultrasonic coupling agent described in any one of the above or an ultrasonic coupling agent prepared by the preparation method of any one of the above, and its use as a coupling medium in an ultrasonic device.

[0024] The above-mentioned ultrasonic coupling agent includes the following components in percentage by mass: 10 to 30 parts of glycerol, 0.5 to 3 parts of nano-silicon dioxide and 70 to 90 parts of deionized water. Among them, glycerol itself is a colorless, transparent, odorless viscous liquid that can match the acoustic impedance of human tissue, thereby improving the efficiency of ultrasonic propagation. At the same time, compared with traditional ultrasonic coupling agents using degassed water, the ultrasonic coupling agent of the present application has a longer gas re-dissolution time and higher stability, which can reduce the interference of bubbles generated after the gas is re-dissolved, thereby improving the treatment effect. At the same time, nano-silicon dioxide can make the ultrasonic coupling agent have a cavitation effect, which can further reduce the generation of bubbles in the ultrasonic coupling agent and further improve the efficiency of ultrasonic propagation. Within the range of the mass fractions of the various components of the above-mentioned ultrasonic coupling agent, the ultrasonic coupling agent of the present application can improve the efficiency of ultrasonic propagation while having good stability. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 A schematic structural diagram of an apparatus for preparing an ultrasonic coupling agent provided in one embodiment of the present application. DETAILED DESCRIPTION

[0026] To make the above-mentioned objects, features, and advantages of the present application more clearly understood, the specific embodiments of the present application are described in detail below. The following description sets forth many specific details to facilitate a full understanding of the present application. However, the present application can be implemented in many other ways than those described herein, and those skilled in the art can make similar modifications without violating the scope of the present application. Therefore, the present application is not limited to the specific embodiments disclosed below.

[0027] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art to which this application pertains. The terms used herein in the specification of this application are for the purpose of describing specific embodiments only and are not intended to limit this application. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0028] In the description of the present application, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present application.

[0029] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be understood to indicate or imply relative importance or implicitly specify the number of the technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one of such features. In the description of this application, "plurality" means at least two, for example, two, three, etc., unless otherwise specifically defined.

[0030] In this application, unless otherwise specified or limited, the terms "installed," "connected," "connect," "fixed," etc. should be understood in a broad sense. For example, they can refer to fixed connection, detachable connection, or integration; mechanical connection or electrical connection; direct connection or indirect connection through an intermediate medium; internal communication between two elements or interaction between two elements, unless otherwise specified. Those skilled in the art will understand the specific meanings of the above terms in this application based on specific circumstances.

[0031] One embodiment of the present application provides an ultrasonic coupling agent, comprising the following components in the following mass percentages:

[0032] 10 to 30 parts of glycerol, 0.5 to 3 parts of nano-silicon dioxide and 70 to 90 parts of deionized water.

[0033] The above-mentioned ultrasonic coupling agent includes the following components in percentage by mass: 10 to 30 parts of glycerol, 0.5 to 3 parts of nano-silicon dioxide and 70 to 90 parts of deionized water. Among them, glycerol itself is a colorless, transparent, odorless viscous liquid that can match the acoustic impedance of human tissue, thereby improving the efficiency of ultrasonic propagation. At the same time, compared with traditional ultrasonic coupling agents using degassed water, the ultrasonic coupling agent of the present application has a longer gas re-dissolution time and higher stability, which can reduce the interference of bubbles generated after the gas is re-dissolved. At the same time, nano-silicon dioxide can make the ultrasonic coupling agent have a cavitation effect, which can further reduce the generation of bubbles in the ultrasonic coupling agent and further improve the efficiency of ultrasonic propagation. Within the range of the mass fractions of the various components of the above-mentioned ultrasonic coupling agent, the ultrasonic coupling agent of the present application can improve the efficiency of ultrasonic propagation while having good stability.

[0034] In some embodiments, the ultrasonic couplant does not contain ethylene glycol.

[0035] Furthermore, compared to traditional ultrasonic coupling agents using ethylene glycol, the ultrasonic coupling agent of this application eliminates the toxicity of industrial solutions and the risk of leakage that could harm users. This application uses propylene glycol instead of traditional ethylene glycol. Glycerol itself is a colorless, transparent, odorless, viscous liquid that is non-toxic and harmless. As a replacement for ethylene glycol, it is more environmentally friendly and biodegradable, causing no environmental pollution. Furthermore, the ultrasonic coupling agent of this application can adapt to more extreme environments, is less likely to volatilize at high temperatures, and has a higher antifreeze temperature.

[0036] The ultrasonic transmission efficiency of an ultrasonic coupling agent refers to its ability to transmit ultrasonic energy during ultrasonic examinations, and is usually measured by the energy transmittance or attenuation of the ultrasonic wave after passing through the coupling agent layer. The core factors affecting the ultrasonic transmission efficiency of an ultrasonic coupling agent are: (1) Acoustic impedance matching. The energy transmittance of ultrasonic waves at the interface between two media is related to the difference in acoustic impedance (sound velocity × density) of the media. The acoustic impedance of the ultrasonic coupling agent in this application is close to that of human tissue, which can reduce interface reflection losses. (2) Acoustic attenuation characteristics. Bubbles in the ultrasonic coupling agent will reflect and scatter ultrasonic waves, causing ultrasonic energy attenuation. Compared with traditional degassed water, the ultrasonic coupling agent in this application can extend the gas re-dissolution time by more than 50%, ensuring that the energy loss of ultrasonic waves is small when propagating in the coupling agent layer. (3) Physical state and uniformity. Viscosity: A coupling agent that is too thin is easy to flow, resulting in bubbles between the probe and the skin; a coupling agent that is too thick may be difficult to apply evenly, forming local gaps. Both will produce strong reflections due to the involvement of air, significantly reducing the transmission efficiency. The ultrasonic coupling agent of the present application has a moderate viscosity and can be applied evenly with few bubbles remaining. (4) Temperature and environmental factors. Temperature changes can affect the viscosity and molecular structure of the ultrasonic coupling agent. For example, low temperatures may cause the gel to thicken and its fluidity to decrease, affecting its uniformity; high temperatures may cause it to become thinner and easier to flow, both of which may indirectly reduce the transmission efficiency. The ultrasonic coupling agent of the present application has a strong ability to withstand temperature changes, and the effect of temperature changes on its properties is relatively small. In summary, the ultrasonic coupling agent of the present application can improve the efficiency of ultrasonic transmission through the above-mentioned multi-faceted performance improvements.

[0037] Optionally, the mass fraction of glycerol is 10 parts, 12 parts, 14 parts, 16 parts, 18 parts, 20 parts, 22 parts, 24 parts, 26 parts, 28 parts or 30 parts, or the mass fraction of glycerol can also be within the range between any two of the above mass fractions.

[0038] Optionally, the mass fraction of the nano-silicon dioxide is 0.5 parts, 1 parts, 1.5 parts, 2 parts, 2.5 parts or 3 parts, or the mass fraction of the nano-silicon dioxide can also be within the range between any two of the above mass fractions.

[0039] Optionally, the mass fraction of deionized water is 70 parts, 72 parts, 74 parts, 76 parts, 78 parts, 80 parts, 82 parts, 84 parts, 86 parts, 88 parts or 90 parts, or the mass fraction of deionized water can also be within the range between any two of the above mass fractions.

[0040] In some embodiments, the D50 particle size of the nano-silica is 30 nm to 80 nm.

[0041] Within the aforementioned D50 particle size range, the nano-silica exhibits a better cavitation effect on the ultrasonic coupling agent. Alternatively, the D50 particle size of the nano-silica is 30 nm, 35 nm, 40 nm, 45 nm, 50 nm, 55 nm, 60 nm, 65 nm, 70 nm, 75 nm, or 80 nm. Alternatively, the D50 particle size of the nano-silica may be within a range between any two of the aforementioned D50 particle sizes.

[0042] In some embodiments, the ultrasonic coupling agent further includes 1 to 5 parts by weight of a non-ionic surfactant.

[0043] The nonionic surfactant can enhance the solubility of organic matter. Optionally, the mass fraction of the nonionic surfactant is 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts or 5 parts, or the mass fraction of the nonionic surfactant can also be within the range between any two of the above mass fractions.

[0044] In some embodiments, the nonionic surfactant comprises a polyoxyethylene castor oil solution.

[0045] Cremophor EL (CRL) is a nonionic surfactant made from castor oil and ethylene oxide through an addition reaction. Its molecular structure consists of lipophilic castor oil fatty acid segments and hydrophilic polyoxyethylene (PEG) segments. As a nonionic surfactant, it offers the following significant advantages: Nonionic properties. The absence of charged groups (such as anions or cations) in the molecule makes it less susceptible to electrostatic interactions with surface charges on biological membranes (such as cell membrane phospholipids), resulting in less irritation to skin, mucous membranes, and eye tissues. It also exhibits low toxicity. It also exhibits strong solubilizing and emulsifying abilities. The hydrophilicity of the polyoxyethylene (PEG) segment enables it to effectively solubilize both lipid-soluble and water-soluble drugs. It also exhibits excellent chemical stability and compatibility. Its nonionic structure makes it stable over a wide pH range and is not susceptible to precipitation or inactivation by strong acids, bases, or electrolytes (such as salts). It also exhibits excellent compatibility with other ingredients. It is not easy to have charge interactions with drugs or excipients (such as proteins and polysaccharides) and can be used in combination with most surfactants (such as Tween and Span) to synergistically enhance the emulsification or solubilization effect. It has good biocompatibility.

[0046] In some embodiments, the mass percentage of polyoxyethylene castor oil in the polyoxyethylene castor oil solution is 8% to 15%.

[0047] Optionally, the mass percentage of polyoxyethylene castor oil in the polyoxyethylene castor oil solution is 8%, 9%, 10%, 11%, 12%, 13%, 14% or 15%, or the mass percentage of polyoxyethylene castor oil in the polyoxyethylene castor oil solution may also be within the range between any two of the above mass percentages.

[0048] In some embodiments, the solvent of the polyoxyethylene castor oil solution is an alcohol solvent.

[0049] In some embodiments, the solvent of the polyoxyethylene castor oil solution is ethanol.

[0050] In some embodiments, the ultrasonic coupling agent comprises the following components in the following mass percentages: 10 to 30 parts of glycerol, 0.5 to 3 parts of nano-silicon dioxide, 70 to 90 parts of deionized water, and 1 to 5 parts of a non-ionic surfactant.

[0051] In some embodiments, the oxygen content in the ultrasonic coupling agent is less than or equal to 1 mg / L.

[0052] The oxygen content in the ultrasonic coupling agent can be achieved by performing a water vapor separation process on deionized water or degassing the ultrasonic coupling agent. Optionally, the oxygen content in the ultrasonic coupling agent is less than or equal to 0.8 mg / L, or less than or equal to 0.6 mg / L, or less than or equal to 0.4 mg / L, or less than or equal to 0.2 mg / L, or less than or equal to 0.1 mg / L, or less than or equal to 0.05 mg / L, or less than or equal to 0.01 mg / L.

[0053] Another embodiment of the present application provides a method for preparing an ultrasonic coupling agent, comprising the following steps:

[0054] The following components are mixed in mass percentage: 10 to 30 parts of glycerol, 0.5 to 3 parts of nano-silicon dioxide, and 70 to 90 parts of deionized water.

[0055] In some embodiments, the method for preparing the ultrasonic coupling agent comprises the following steps:

[0056] The following components are mixed in mass percentage: 10 to 30 parts of glycerol, 0.5 to 3 parts of nano-silicon dioxide, 70 to 90 parts of deionized water, and 1 to 5 parts of a nonionic surfactant.

[0057] In some embodiments, the steps include:

[0058] Mix 10 to 30 parts by mass of glycerol, 0.5 to 3 parts by mass of nano-silicon dioxide, and 1 to 5 parts by mass of a non-ionic surfactant to obtain a premixed raw material;

[0059] Perform water-gas separation on 70 to 90 parts of deionized water;

[0060] Mixing the premixed raw materials and deionized water after water vapor separation to obtain a mixed liquid;

[0061] The mixed solution was degassed.

[0062] Reference Figure 1 As shown, in some embodiments, an ultrasonic coupling agent preparation device is used for preparation, and the ultrasonic coupling agent preparation device includes: a premixing device, a water-gas separation device, a liquid storage device, a mixing device, and a degassing device; the discharge end of the premixing device is connected to the feed end of the mixing device; the discharge end of the water-gas separation device is connected to the feed end of the liquid storage device; the discharge end of the liquid storage device is connected to the feed end of the mixing device; and the discharge end of the mixing device is connected to the feed end of the degassing device; and the following steps are included:

[0063] Mixing 10 to 30 parts by mass of glycerol, 0.5 to 3 parts by mass of nano-silicon dioxide, and 1 to 5 parts by mass of a non-ionic surfactant in a premixing device to obtain a premixed raw material;

[0064] Using a water-gas separation device to perform water-gas separation treatment on 70 to 90 parts of deionized water, and storing the deionized water after the water-gas separation treatment in a liquid storage device;

[0065] Adding deionized water in the liquid storage device and the premixed raw materials in the premixing device into the mixing device and mixing them to obtain a mixed liquid;

[0066] Degas the mixed solution using a degasser.

[0067] In some embodiments, adding deionized water in the liquid storage device and the premixed raw materials in the premixing device to the mixing device for mixing comprises the following steps:

[0068] The deionized water in the liquid storage device and the premixed raw materials in the premixing device are added to the mixing device, and stirred at a speed of 400 rpm to 1000 rpm for 20 min to 40 min.

[0069] Optionally, the stirring speed is 400 rpm, 500 rpm, 600 rpm, 700 rpm, 800 rpm, 900 rpm or 1000 rpm, or the stirring speed may also be within a range between any two of the above speeds.

[0070] Optionally, the stirring time is 20 min, 22 min, 24 min, 26 min, 28 min, 30 min, 32 min, 34 min, 36 min, 38 min or 40 min, or the stirring time may be within the range between any two of the above times.

[0071] In some embodiments, degassing the mixed liquid using a degasser comprises the following steps:

[0072] Transfer the mixed solution to a degasser;

[0073] Evacuate the degassing device to a vacuum degree of more than 0.095 MPa for more than 15 minutes.

[0074] Another embodiment of the present application provides an ultrasonic coupling agent according to any one of the above items or an ultrasonic coupling agent prepared by the preparation method of any one of the above items, and uses the ultrasonic coupling agent as a coupling medium in an ultrasonic device.

[0075] In some embodiments, the ultrasound device is used for at least one of ultrasound therapy, ultrasound diagnosis, ultrasound beauty, ultrasound detection, and ultrasound sensing.

[0076] Refer again Figure 1 As shown, another embodiment of the present application also provides an ultrasonic coupling agent preparation device, including: a premixing device, a water-gas separation device, a liquid storage device, a mixing device and a degassing device; the discharge end of the premixing device is connected to the feed end of the mixing device; the discharge end of the water-gas separation device is connected to the feed end of the liquid storage device; the discharge end of the liquid storage device is connected to the feed end of the mixing device; and the discharge end of the mixing device is connected to the feed end of the degassing device.

[0077] In some embodiments, the premixing device is a liquid storage container with an automatic stirrer.

[0078] In some embodiments, the water-gas separation device and the degassing device each include a circulating degassing system in which a water ring vacuum pump is coupled to a water-gas separator.

[0079] In some embodiments, the ultrasonic coupling agent preparation apparatus further includes a conveying device connected to a discharge end of the degassing device. The conveying device is used to deliver the degassed ultrasonic coupling agent to the treatment device.

[0080] The following are specific embodiments

[0081] Example 1

[0082] The ultrasonic coupling agent in Example 1 is composed of the following components in the following mass percentages: 20% glycerol, 3% nano-silicon dioxide, 76% deionized water, and 1% polyoxyethylene castor oil solution, wherein the D50 particle size of the nano-silicon dioxide is 50 nm.

[0083] Example 2

[0084] The ultrasonic coupling agent in Example 2 is composed of the following components in the following mass percentages: 10% glycerol, 3% nano-silicon dioxide, 86% deionized water, and 1% polyoxyethylene castor oil solution, wherein the D50 particle size of the nano-silicon dioxide is 50 nm.

[0085] Example 3

[0086] The ultrasonic coupling agent in Example 3 is composed of the following components in the following mass percentages: 30% glycerol, 3% nano-silicon dioxide, 66% deionized water, and 1% polyoxyethylene castor oil solution, wherein the D50 particle size of the nano-silicon dioxide is 50 nm.

[0087] Example 4

[0088] The ultrasonic coupling agent in Example 4 is composed of the following components in the following mass percentages: 20% glycerol, 1% nano-silicon dioxide, 78% deionized water, and 1% polyoxyethylene castor oil solution, wherein the D50 particle size of the nano-silicon dioxide is 50 nm.

[0089] Example 5

[0090] The ultrasonic coupling agent in Example 5 is composed of the following components in the following mass percentages: 20% glycerol, 3% nano-silicon dioxide, 72% deionized water, and 5% polyoxyethylene castor oil solution, wherein the D50 particle size of the nano-silicon dioxide is 50 nm.

[0091] Comparative Example 1

[0092] The ultrasonic coupling agent in Comparative Example 1 is composed of the following components in the following mass percentages: 5% glycerol, 3% nano-silicon dioxide, 91% deionized water, and 1% polyoxyethylene castor oil solution, wherein the D50 particle size of the nano-silicon dioxide is 50 nm.

[0093] Comparative Example 2

[0094] The ultrasonic coupling agent in Comparative Example 2 is composed of the following components in the following mass percentages: 3% nano-silicon dioxide, 96% deionized water, and 1% polyoxyethylene castor oil solution, wherein the D50 particle size of the nano-silicon dioxide is 50 nm.

[0095] Comparative Example 3

[0096] The ultrasonic coupling agent in Comparative Example 3 is composed of the following components in the following mass percentages: 20% glycerol, 79% deionized water, and 1% polyoxyethylene castor oil solution, wherein the D50 particle size of the nano-silica is 50 nm.

[0097] Comparative Example 4

[0098] The ultrasonic coupling agent in Comparative Example 4 is composed of the following components in the following mass percentages: 20% ethylene glycol, 3% nano-silicon dioxide, 76% deionized water, and 1% polyoxyethylene castor oil solution, wherein the D50 particle size of the nano-silicon dioxide is 50 nm.

[0099] It should be noted that the deionized water in the aforementioned examples and comparative examples was deionized water that had undergone a water-gas separation process. The water-gas separation process involved evacuating the deionized water to a vacuum of 0.095 MPa in an apparatus for 15 minutes. The polyoxyethylene castor oil solution was an ethanol solution of polyoxyethylene castor oil, wherein the mass concentration of the polyoxyethylene castor oil was 10%.

[0100] The ultrasonic propagation efficiency of the ultrasonic coupling agents in Examples 1 to 5 and Comparative Examples 1 to 4 was tested, wherein the ultrasonic propagation efficiency was measured by a sound power meter. The components of each ultrasonic coupling agent and the test results are shown in Table 1 below:

[0101] Table 1

[0102]

[0103] It can be seen from the above test results that the ultrasonic coupling agents in the embodiments of the present application can have higher ultrasonic transmission efficiency than the ultrasonic coupling agents in comparative examples 1 to 4.

[0104] The technical features of the above-mentioned embodiments can be combined arbitrarily. In order to make the description concise, not all possible combinations of the technical features in the above-mentioned embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0105] The above-described embodiments merely represent several implementation methods of the present application. While the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the patent. It should be noted that a person skilled in the art could make several modifications and improvements without departing from the spirit of the present application, all of which fall within the scope of protection of the present application. Therefore, the scope of protection of the patent in this application shall be based on the appended claims, and the specification and drawings may be used to interpret the claims.

Claims

1. An ultrasonic coupling agent, characterized in that: The following components are included in mass percentage: 10 to 30 parts of glycerol, 0.5 to 3 parts of nano-silicon dioxide and 70 to 90 parts of deionized water.

2. The ultrasonic coupling agent according to claim 1, characterized in that The D50 particle size of the nano-silicon dioxide is 30nm~80nm.

3. The ultrasonic coupling agent according to claim 1, characterized in that The ultrasonic coupling agent further includes 1 to 5 parts by mass of a non-ionic surfactant.

4. The ultrasonic coupling agent according to claim 3, characterized in that: The nonionic surfactant includes polyoxyethylene castor oil solution.

5. The ultrasonic coupling agent according to claim 4, characterized in that: The mass percentage of polyoxyethylene castor oil in the polyoxyethylene castor oil solution is 8% to 15%.

6. The ultrasonic coupling agent according to any one of claims 1 to 5, characterized in that: The oxygen content in the ultrasonic coupling agent is less than or equal to 1 mg / L.

7. A method for preparing an ultrasonic coupling agent, characterized in that: The steps include: The following components are mixed in mass percentage: 10 to 30 parts of glycerol, 0.5 to 3 parts of nano-silicon dioxide, and 70 to 90 parts of deionized water.

8. The method for preparing the ultrasonic coupling agent according to claim 7, characterized in that: The steps include: Mix 10 to 30 parts by mass of glycerol, 0.5 to 3 parts by mass of nano-silicon dioxide, and 1 to 5 parts by mass of a non-ionic surfactant to obtain a premixed raw material; Perform water-gas separation on 70 to 90 parts of deionized water; Mixing the premixed raw material and deionized water after water vapor separation to obtain a mixed liquid; The mixed liquid is degassed.

9. The method for preparing an ultrasonic coupling agent according to claim 7 or 8, wherein the ultrasonic coupling agent is prepared using an ultrasonic coupling agent preparation device, wherein the ultrasonic coupling agent preparation device comprises: Premixing device, water-gas separation device, liquid storage device, mixing device and degassing device; The discharge end of the premixing device is connected to the feed end of the mixing device; The discharge end of the water-gas separation device is connected to the feed end of the liquid storage device; the discharge end of the liquid storage device is connected to the feed end of the mixing device; the discharge end of the mixing device is connected to the feed end of the degassing device; characterized in that it includes the following steps: Mixing 10 to 30 parts by mass of glycerol, 0.5 to 3 parts by mass of nano-silicon dioxide, and 1 to 5 parts by mass of a non-ionic surfactant in the premixing device to obtain a premixed raw material; Using the water-gas separation device to perform water-gas separation treatment on 70 to 90 parts of deionized water, and storing the deionized water after the water-gas separation treatment in the liquid storage device; adding the deionized water in the liquid storage device and the premixed raw materials in the premixing device into the mixing device and mixing them to obtain a mixed liquid; The mixed liquid is degassed using the degassing device.

10. Use of the ultrasonic coupling agent according to any one of claims 1 to 6 or the ultrasonic coupling agent prepared by the preparation method of any one of claims 7 to 9 as a coupling medium in an ultrasonic device.

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