Composition comprising polar phase and non-polar phase

Abstract

The present invention relates to a composition comprising a polar phase and a non-polar phase, wherein the composition comprises a lipophilic extract of ginger and at least one other lipophilic ingredient; the polar phase contains at least 20% by weight of a polyol, greater than 3% by weight and less than 20% by weight of water, and at least one hydrophilic component, based on the total weight of the polar phase; and each 100 g of the composition contains 0.5 g to 10 g of lecithin.

Description

Technical Field

[0001] The present invention relates to compositions comprising a polar phase and a non-polar phase. Background Art

[0002] Biphasic systems (i.e., systems consisting of a polar phase and a non-polar phase) are an important type of formulation and are widely used in nutritional supplements, cosmetic preparations and other fields.

[0003] WO 2019 / 233552 A1 describes the requirements for biphasic systems: they must be drop-able and transparent, and even when using natural ingredients, they must possess good physical, chemical, and microbiological stability. The document also describes emulsions—complex biphasic systems consisting of two immiscible phases, one of which is stably dispersed in the form of droplets within the other. The long-term quality and storage properties of emulsions and similar biphasic systems are determined by three types of stability: physical stability, chemical stability, and microbiological stability.

[0004] Physical stability refers to the ability of a two-phase system to maintain a fine, uniform distribution of the dispersed phase, mechanically formed, over an extended period of time. For example, physical stability can be improved by using surfactants (or emulsifiers) to balance the densities of the two phases, or by increasing the viscosity of the external phase with the help of so-called "quasi-emulsifiers." Surfactants are categorized as anionic, cationic, amphoteric, and nonionic. Nonionic surfactants offer significant advantages: they do not form ions in water, react neutrally, are unaffected by electrolytes, and are less sensitive to chemical reactions.

[0005] Particularly in the dietary and cosmetic sectors, transparent or at least translucent two-phase systems are preferred. In some cases, this can be achieved by reducing the internal phase droplet size to the nanoscale, for example, by micelles (the formation of which can be mediated by emulsifiers and co-emulsifiers). Ethoxylated surfactants or high-HLB synthetic surfactants are typically used as emulsifiers, with alcohols used as co-emulsifiers. However, emulsifying oils and fats often requires large amounts of emulsifiers and co-emulsifiers, and synthetic emulsifiers are easily rejected by some people. In addition, alcohols such as ethanol and propanol are cytotoxic and should be strictly avoided in oral preparations for children, alcoholics, pregnant women, and other groups.

[0006] In addition to physical stability, a two-phase system must also ensure chemical and microbial stability. Chemical stability is particularly critical in a two-phase system: the presence of water exacerbates the auto-oxidation and hydrolysis of oils and fats, and the air (containing oxygen) introduced during the preparation process also promotes oxidation. This not only causes the oxidized fatty acids to lose their physiological functions, but may even produce harmful substances. In practice, in addition to solvents, it is generally necessary to avoid adding hydrophilic components to the two-phase system because they can have a negative impact on chemical stability.

[0007] As aqueous systems, biphasic systems are susceptible to becoming a nutrient matrix for microorganisms, necessitating the addition of preservatives. However, the surfactants required for physical stability can reduce the effectiveness of preservatives, and some preservatives can migrate into the lipophilic phase. Therefore, to ensure sufficient preservative concentrations in the aqueous phase, these biphasic systems often require high preservative levels. However, some preservatives, such as parabens, can cause intolerance and allergic reactions.

[0008] Despite the technical challenges, there is a significant demand for products based on compatible natural ingredients or excipients. Two-phase systems, such as emulsions, are complex, and ingredients cannot be mixed freely. Therefore, developing a formulation that meets user needs while also achieving high stability is crucial. Summary of the Invention

[0009] The purpose of the present invention is to provide an improved two-phase system to optimize nutrient delivery, and to have good applicability, be non-allergenic, and be easily accepted by the human body; in addition, since it does not contain monohydric alcohols (especially ethanol and propanol), physical stability, chemical stability, and microbiological stability can be achieved only through natural ingredients, while avoiding the use of synthetic emulsifiers and preservatives.

[0010] According to the invention, this object is achieved by the composition according to claim 1 . DETAILED DESCRIPTION

[0011] The core of the present invention is to provide a composition comprising a polar phase and a non-polar phase, wherein: the composition contains a lipophilic extract of ginger (Zingiber officinale) and at least one other lipophilic ingredient; based on the total weight of the polar phase, the polar phase contains at least 20% by weight of a polyol, 3%-20% by weight of water, and at least one hydrophilic ingredient; and each 100g of the composition contains 0.5g-10g of lecithin.

[0012] In addition to lecithin, ginger lipophilic extract, and water and polyols in the polar phase, the polar phase also contains at least one hydrophilic (polar) component, and the non-polar phase (lipophilic) contains at least one other lipophilic (non-polar) component. The composition can simultaneously deliver hydrophilic and hydrophobic components in a stable form and promote their efficient absorption, thereby realizing the "Nutrient Transport Concept (NTC)" - hydrophilic components are dissolved in the polar phase, and fat-soluble components are dissolved in the non-polar phase, and are then quickly and massively absorbed. This technology that combines fat-soluble and hydrophilic substances is also called "Microsolve+ technology", which is an improvement on Microsolve technology: using natural food-grade solubilizers (such as soy lecithin) to finely disperse and pre-dissolve (such as micellization) fat-soluble substances in the aqueous phase to promote their dispersion and absorption in the gastrointestinal tract.

[0013] Lipophilic ginger extracts act as bioenhancers, promoting absorption and helping achieve NTC. Extracts from ginger rhizomes (especially dried ginger rhizomes that meet European Pharmacopoeia standards) are preferred, with supercritical CO2 extracts being more preferred.

[0014] In this composition, the lipophilic (non-polar) phase can be finely and evenly dispersed in the aqueous (polar) phase for a long period of time, thus providing physical stability. The composition utilizes only lecithin as an emulsifier, and the amount used is relatively small compared to the amount of the substance to be emulsified. For example, the mass of lecithin can be 5% of the mass of the lipid to be emulsified. Furthermore, the lecithin is of natural origin.

[0015] Monohydric alcohols (such as ethanol and propanol) are not necessary to maintain the stability of the composition. However, the use of monohydric alcohols is not excluded in the various embodiments of the composition of the present invention. This principle also applies to synthetic surfactants. One advantage of the composition according to the present invention is that it is suitable for people who cannot use monohydric alcohols (such as ethanol and propanol) (such as children, alcoholics, pregnant women, etc.). Another advantage of the composition according to the present invention is that it is also suitable for people who exclude the use of synthetic surfactants (when they are not actually used in the formulation).

[0016] Polyols can assist in preservation, and no other preservatives are needed besides the above ingredients, so synthetic or allergenic preservatives can be avoided.

[0017] Surprisingly, despite the presence of water and hydrophilic components, the lipophilic components that are susceptible to oxidation and hydrolysis can remain stable, ensuring the content of active ingredients while avoiding the formation of harmful substances.

[0018] In summary, a stable biphasic composition can be formed only by natural ingredients, which is easily accepted by the human body, has good tolerance, and has a low risk of allergy.

[0019] In some embodiments, the two-phase system is an emulsion.

[0020] For example, lecithin is primarily composed of phosphatidylcholine. Phosphatidylcholine is 1,2-diacyl-sn-glycero-3-phosphocholine, in which phosphoric acid is esterified with diacylglycerol and choline. Under the Food Additives Permit Ordinance (ZZulV 1998), it is approved for widespread use as a food additive (except in certain foods) under the E322 designation.

[0021] In some embodiments, each 100g composition provided by the present invention contains 0.5-10g (preferably 1-3.5g) of lecithin. The lecithin is primarily located at the interface of the polar phase and the non-polar phase. That is, in addition to the polar phase and the non-polar phase, the composition also includes a lecithin phase composed of the lecithin in the composition. The phosphatidylcholine content in the lecithin is 30% to 100% by weight, that is, each 100g composition contains 0.15-10g (preferably 0.3-3.5g, more preferably 1-3g) of phosphatidylcholine. Preferably, a de-oiled lecithin fraction is used as the lecithin. This means that the lecithin is essentially free of non-polar lipids such as fatty acids and triglycerides. The content of non-polar lipids is preferably <3% by weight. Lecithin contains a certain proportion of polar lipids (acetone insoluble matter), accounting for 90%-100% by weight. Lecithin source can be selected from soybean, sunflower, rapeseed, fish, milk, egg and mixture thereof, preferably non-animal source (soybean, sunflower, rapeseed).Except phosphatidylcholine, lecithin also can contain phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, sterol, grease etc.For example, soybean lecithin contains 40%-50% weight phosphatidylcholine, about 10% weight phosphatidylethanolamine, about 5% weight phosphatidylinositol, about 1% to 2% weight phosphatidylserine, sterol, grease.Egg yolk lecithin main component is phosphatidylcholine.

[0022] The polar phase contains water and glycerol, while the non-polar phase can be composed of fatty acids and their esters (such as triglycerides and ethyl esters), fat-soluble vitamins, carotenoids (e.g., lutein and zeaxanthin), vitamin A and its derivatives (retinal, retinyl palmitate, and retinyl acetate), vitamin E and its derivatives (vitamin E, a general term for tocopherols and tocotrienols), including α-, β-, γ-, and δ-tocopherol and tocotrienols (including natural mixtures and synthetically purified forms; vitamin E derivatives such as α-, β-, γ-, and δ-tocopheryl acetate (including optically pure forms and racemic forms)), vitamin D2, vitamin D3, vitamin K1, vitamin K2, vitamin K3, coenzyme Q10H, ubiquinone-10, and perfluorocarbon compounds. Extracts can also serve as a source of non-polar phase components.

[0023] When calculating the proportion of polar phase components, lecithin is not included in the polar phase. In case of doubt (unless otherwise specified in the instructions), lipophilic compounds containing phosphate / phosphate groups are considered lecithin, and those without are considered lipophilic components.

[0024] The embodiments described in the examples of the present invention may be combined arbitrarily unless there is an explicit contradiction.

[0025] In the description of the embodiments of the present invention, the verb "comprise" and its variations include "consist of" and its variations.

[0026] Preferred embodiments of the invention are described in the dependent claims.

[0027] In some embodiments, the composition is liquid at 20°C. Preferably, the liquid has a viscosity of 100 to 3000 mPa·s at 20°C. This liquid dosage form offers multiple advantages, allowing the active ingredients in the formulation to move freely, thereby enhancing their absorption efficiency. Due to its liquid nature, the composition of the present invention can achieve NTC. The liquid formulation promotes rapid and efficient absorption of the ingredients.

[0028] The viscosity mentioned here is the dynamic viscosity, which is measured using a cone-plate rotational viscometer according to the European Pharmacopoeia 7.0 (2011) method.

[0029] In some embodiments, the composition contains liposomes. Liposomes form when the lecithin / phosphatidylcholine content exceeds the amount required to emulsify the non-polar phase. Emulsifier molecules (lecithin) not used to stabilize the non-polar phase (e.g., fat droplets) can form liposome structures in the polar phase. These liposomes serve as a specialized carrier system for water-soluble, hydrophilic active ingredients. Consequently, two specialized carriers exist in the system: the fat droplets carrying the lipophilic active ingredient, and the liposomes carrying the hydrophilic active ingredient. During formulation production, the use of a high-pressure homogenizer can facilitate liposome formation. As mentioned at the outset, combining lipophilic and hydrophilic substances in a single carrier system is also referred to as microsolve+ technology. The hydrophilic and lipophilic components can be dissolved in the polar and non-polar phases, respectively, enabling rapid and efficient absorption after use, thereby achieving NTC.

[0030] In some embodiments, the polyol is one or more of glycerol, erythritol, sorbitol, and fructose. These ingredients are particularly suitable for stabilizing the formulation system. Preferably, the polyol is glycerol.

[0031] Based on the total weight of the polar phase, the polar phase preferably contains 40% to 96% by weight (more preferably 60% to 90% by weight) of polyol to ensure the anti-corrosion effect.

[0032] The polar phase contains 3% to 20% by weight (preferably 5% to 17% by weight) of water, based on the total weight of the polar phase.

[0033] In some embodiments, the composition contains lutein and zeaxanthin as other lipophilic ingredients.

[0034] In some embodiments, each 100g composition contains 0.01g-4.0g of peppermint extract (preferably Menthapiperita extract) as a lipophilic ingredient. Surprisingly, peppermint extract can further enhance the body's absorption of ingredients, thus acting as a bioenhancer. By adding one or more bioenhancers, the compositions of the present invention can achieve the construction of an NTC. Extracts of the aerial parts of peppermint (particularly the flowering parts) are preferred, and conform to the European Pharmacopoeia standards. The extract can be obtained by steam distillation, preferably using supercritical carbon dioxide extraction (CO2-destraction extraction).

[0035] In some embodiments, the composition contains at least one ω-3 fatty acid selected from docosahexaenoic acid, α-linolenic acid, and eicosapentaenoic acid as another lipophilic component. Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) constitute important components of human dietary nutrition. Daily dietary structure and dietary choices are usually difficult to meet the human body's demand for ω-3 fatty acids. Existing ω-3 supplements (especially in the form of fish oil capsules) generally have low digestion and absorption rates, are prone to causing adverse reactions such as belching and nausea, and are accompanied by a noticeable fishy odor and unpleasant taste. Fish oil capsules may also be rejected by consumers due to concerns about prion risks, vegetarian / vegan lifestyles, or religious beliefs. Direct intake of oily substances (especially oils containing ω-3 fatty acids) often brings discomfort or negative associations to consumers, resulting in low compliance and ultimately causing the problem of continued insufficient intake of ω-3 fatty acids. The composition provided in the embodiments of the present invention can mask the odor and taste of these ingredients, thereby improving compliance. The composition also promotes the body's absorption of these compounds, and in a breakthrough, stabilizes ω-3 fatty acids or their esters, which are susceptible to oxidation and hydrolysis, in the presence of aqueous environments, hydrophilic components, and oxygen. NTC and Microsolve technologies promote efficient cellular absorption of polyunsaturated fatty acids.

[0036] In some embodiments, the compositions contain Coenzyme Q10 as an additional lipophilic component. The compositions of the present invention can enhance the stability and absorption of these compounds by the human body. NTC and Microsolve technology can also improve the bioavailability of Coenzyme Q10.

[0037] In some embodiments, at least one hydrophilic component is selected from vitamin C, B vitamins (B1, B2, B3, B6, B7 (biotin), B12), minerals, trace elements, and oligomeric proanthocyanidins.

[0038] In some embodiments, the composition comprises isoflavones.

[0039] In some embodiments, the composition contains 0.01 g to 2.0 g of the lipophilic ginger extract per 100 g of the composition. Within this dosage range, the lipophilic ginger extract can achieve optimal efficacy. Due to the inclusion of one or more bioenhancers, the composition of the present invention can achieve NTC.

[0040] In some embodiments, each 100g composition contains 0.5g-5.0g of triglycerides (preferably medium-chain triglycerides) as a lipophilic ingredient. Triglycerides can serve as a carrier for lipophilic ingredients. The use of triglycerides stabilizes the formulation. Furthermore, triglycerides form a durable oil film on the body surface, allowing the lipophilic ingredient to diffuse and exert its efficacy.

[0041] In some embodiments, the composition contains at least one lipophilic ingredient selected from vitamin D2, vitamin D3 and its derivatives, vitamin A and its derivatives, vitamin E and its derivatives, vitamin K1, vitamin K2, isoprenoids, curcumin, berry extracts, resveratrol extracts, and artichoke extracts. Curcumin, in particular, can improve the body's utilization of ingredients, which is why it is a preferred ingredient. NTC and Microsolve technologies can improve the bioavailability of ingredients such as vitamin E. Furthermore, the compositions of the present invention, by containing one or more bioenhancers, can achieve NTC.

[0042] In some embodiments, the mass ratio of lecithin to lipophilic component in the composition is 8:1 to 1:20 (more preferably 1:1 to 1:12).

[0043] In some embodiments, the composition contains no animal-derived ingredients. This means that the composition is suitable for vegetarian and vegan lifestyles, particularly vegetarian / vegan diets. Due to limited dietary options, vegetarians (especially vegans) often face deficiencies in specific compounds and related deficiency diseases. This composition offers a significant advantage by providing additional nutritional supplements to these individuals, contributing to a more balanced diet.

[0044] In some embodiments, the composition does not contain any synthetic surfactant. Here, "does not contain" should be understood as the concentration of the compound is extremely low, so low that it will not produce any significant effect. That is, the concentration exceeds the conventional use range of the compound. Synthetic surfactants include the following categories: ethoxylated surfactants; polyethylene glycol and its derivatives (e.g., polyethylene glycol glycerol fatty acid esters (such as polyethylene glycol glycerol ricinoleate); polyethylene glycol fatty acid esters (such as polyethylene glycol oleate); polyethylene glycol fatty alcohol ethers (such as polyoxyethylene cetyl alcohol ether)); propylene glycol and its derivatives, polyoxypropylene-polyoxyethylene block polymers; cellulose and its derivatives (such as hydroxypropyl methylcellulose); benzalkonium chloride; benzalkonium bromide, sodium cetyl sulfate, cetyl pyridine Cetyltrimethylammonium, dequalinium chloride; sodium lauryl sulfate, sodium cetyl sulfate, sodium stearyl sulfate; ethylene glycol monostearate; partial sorbitan fatty acid esters (such as sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan tristearate, sorbitan monooleate, sorbitan sesquioleate, sorbitan trioleate); polysorbate (polyoxyethylene sorbitan fatty acid ester); sucrose fatty acid ester; polyglycerol fatty acid ester; and D-α-tocopherol-1000-succinate, etc.

[0045] In some embodiments, the composition does not contain artificial preservatives ("does not contain" is defined as above). In embodiments of the present invention, artificial preservatives include parabens (such as methyl paraben, propyl paraben), chlorocresol, chlorobutanol, sorbic acid (E 200), potassium sorbate (E 202), calcium sorbate (E 203), sodium edetate, triacetin, benzalkonium chloride, benzalkonium bromide, cetyl ammonium chloride, cetyl pyridine Cetyltrimethylammonium, dequalinium chloride, and organomercury compounds.

[0046] In some embodiments, the composition is free of artificial sweeteners ("free" having the same meaning as above). In this embodiment, artificial sweeteners include acesulfame potassium (E950), alitame (E969), aspartame (E951), aspartame-acesulfame potassium salt (E962), cyclamate (E952), neohesperidin (E959), neotame (E961), saccharin (E954), and sucralose (E955). Steviol glycosides (e.g., steviol glycoside, E960) are not considered artificial sweeteners in the present invention.

[0047] In some embodiments, the composition does not contain monohydric alcohol (such as ethanol, propanol), or the maximum content of monohydric alcohol in every 100g of the composition is 1g. The monohydric alcohol referred to herein includes (for example) ethanol and propanol.

[0048] In some embodiments, the composition does not contain glycols (such as propylene glycol), or the maximum glycol content per 100 g of the composition is 1 g. The glycols defined herein include, for example, propylene glycol.

[0049] In some embodiments, the present invention further provides an infusion device comprising the liquid composition of the present invention, wherein the composition is in liquid form.

[0050] In some embodiments, the present invention also provides a method for preparing the composition, comprising the following steps:

[0051] a) stirring an aqueous solution comprising lecithin, at least 20% by weight of a polyol, 3% to 20% by weight of water, and at least one hydrophilic component;

[0052] b) adding a lipophilic ginger (Zingiber officinale) extract and at least one other lipophilic ingredient to obtain a mixture (containing 0.5 g to 10 g of lecithin per 100 g of the mixture);

[0053] c) stirring the mixture and homogenizing it under high pressure to obtain the composition of the present invention.

[0054] The process temperature is adjusted based on the lecithin and the ingredients to be dissolved. For hydrogenated lecithin, the preferred processing temperature is 40°C to 80°C; unsaturated lecithin can be processed at room temperature. It is preferred to operate above the melting point of the lipophilic ingredient.

[0055] Homogenization is preferably performed using a high-pressure homogenizer, ultrasonic waves, and / or a rotor-stator mixer, with a high-pressure homogenizer being particularly preferred. High-pressure homogenizers can produce more transparent two-phase systems because the internal phase is more finely dispersed. High-pressure homogenizers can ensure that the composition contains liposomes. Surprisingly, even with the introduction of air and water using a high-pressure homogenizer, the auto-oxidation and hydrolysis of oils and lipids in the compositions of the present invention remain low.

[0056] The process (especially the stirring and high-pressure homogenization steps) is preferably carried out under an inert gas atmosphere.

[0057] For other embodiments, advantages and descriptions of the preparation method, reference may be made to the above description of the composition.

[0058] In some embodiments, the present invention also relates to the use of the composition as a nutritional supplement or a cosmetic preparation, and is particularly suitable for use as a nutritional supplement.

[0059] The composition provided by the present invention, comprising a polar phase and a non-polar phase, is particularly suitable for use as a dietary supplement and / or cosmetic formulation. It overcomes the shortcomings of conventional products, can simultaneously deliver hydrophilic and lipophilic ingredients and promote absorption. By using only natural ingredients and without mono- and di-ols, synthetic surfactants, or preservatives, a physically, chemically, and microbiologically stable composition can be obtained, which is particularly effective in promoting human absorption of the ingredients. The composition is easily accepted physiologically and psychologically and has excellent tolerability. Its taste and odor do not cause discomfort and are widely praised. Oral administration can prevent nausea. Because (gelatin) capsules are not used, the preparation of the present invention is also suitable for people who avoid capsules due to concerns about prions, adherence to vegetarian or vegan philosophy, or religious reasons. The viscosity of the two-phase system is suitable.

[0060] Preferred uses include topical application or oral application, especially oral administration.

[0061] With regard to further embodiments, advantages and illustrations, reference is made to the above description of the composition.

[0062] The present invention is further described in detail below with reference to examples of implementation.

[0063] Example 1

[0064] 2.5 g of soybean lecithin with a phosphatidylcholine content of 45% and 0.2 g of vitamin B2 were completely dispersed in 92 g of an 85% (weight percentage) glycerol aqueous solution at 50° C. under stirring.

[0065] Subsequently, 0.3 g of the lipophilic ginger extract and 5 g of vitamin E acetate were added to the dispersion, stirred at 50° C. until uniform, and finally homogenized using a high-pressure homogenizer.

[0066] The result is a stable dispersion whose ingredients can be efficiently absorbed by the human body.

[0067] Example 2

[0068] 2 g of sunflower lecithin with a phosphatidylcholine content of 75% and 0.5 g of nicotinamide were completely dispersed in 85.5 g of an 85% (weight percentage) glycerol aqueous solution at 50° C. under stirring.

[0069] Subsequently, 0.5 g of a lipophilic ginger extract, 2 g of coenzyme Q10, and 10 g of algal oil were added to the dispersion, stirred at 50° C. until uniform, and finally homogenized using a high-pressure homogenizer.

[0070] The result is a stable dispersion whose ingredients can be efficiently absorbed by the human body.

Claims

1. A composition, characterized in that Including polar phase and non-polar phase, wherein the composition comprises a lipophilic extract of ginger and at least one other lipophilic ingredient; Based on the total weight of the polar phase, the polar phase contains at least 20% by weight of a polyol, 3%-20% by weight of water and at least one hydrophilic component; and each 100g of the composition contains 0.5-10g of lecithin.

2. The composition according to claim 1, characterized in that The viscosity of the composition at 20°C is 100 mPa·s-3000 mPa · s.

3. The composition according to claim 1 or 2, characterized in that The composition contains isoflavones.

4. The composition according to any one of claims 1 to 3, characterized in that The composition contains a liposomal structure.

5. The composition according to any one of claims 1 to 4, characterized in that Based on the total weight of the polar phase, the polar phase contains 40% to 96% by weight of the polyol, preferably 60% to 90% by weight of the polyol.

6. The composition according to any one of claims 1 to 5, characterized in that The polyol is glycerol.

7. The composition according to any one of claims 1 to 6, characterized in that The composition contains lutein and zeaxanthin.

8. The composition according to any one of claims 1 to 7, characterized in that The composition contains 0.01-4.0 g of mint extract per 100 g, preferably peppermint extract.

9. The composition according to any one of claims 1 to 8, characterized in that The composition contains ω-3 fatty acids, and the ω-3 fatty acids are selected from docosahexaenoic acid, α-linolenic acid, and eicosapentaenoic acid.

10. The composition according to any one of claims 1 to 9, characterized in that The composition contains coenzyme Q10.

11. The composition according to any one of claims 1 to 10, characterized in that The composition contains, as a hydrophilic component, at least one selected from vitamin C, vitamin B1, vitamin B2, vitamin B3, vitamin B6, vitamin B7 (biotin), vitamin B12, minerals, trace elements and oligomeric proanthocyanidins.

12. The composition according to any one of claims 1 to 11, characterized in that Every 100 g of the composition contains 0.01-2.0 g of the lipophilic ginger extract.

13. The composition according to any one of claims 1 to 12, characterized in that The composition contains 0.5-5.0 g of triglycerides per 100 g, preferably medium-chain triglycerides.

14. The composition according to any one of claims 1 to 13, characterized in that The composition contains at least one lipophilic ingredient selected from the group consisting of vitamin D2, vitamin D3 and its derivatives, vitamin A and its derivatives, vitamin E and its derivatives, vitamin K1, vitamin K2, isoprenoids, curcumin, berry extracts, resveratrol extracts, and artichoke extracts.

15. The composition according to any one of claims 1 to 14, characterized in that The composition contains curcumin.