Optical fiber conduit and preparation method and application thereof

Abstract

The invention provides an optical fiber catheter and a preparation method and application thereof, and belongs to the technical field of medical instruments. The optical fiber catheter provided by the invention comprises a catheter and an optical fiber, the optical fiber is bonded on the outer wall of the catheter through a medical adhesive along the length direction of the catheter; the inner diameter of the guide pipe ranges from 0.4 mm to 0.7 mm. The outer diameter of the conduit is 0.5 to 1mm; the area, 4-6 mm away from the tail end, of one end of the optical fiber is a luminous area. The catheter with the specific inner diameter and outer diameter is adopted, and meanwhile the light transmission efficiency and the light emitting uniformity of the optical fiber catheter are improved. The result of the embodiment shows that the optical transmission efficiency of the optical fiber catheter is 92%, and the light emitting uniformity is 90%.

Description

Technical Field

[0001] The present invention belongs to the technical field of medical devices, and in particular relates to an optical fiber catheter and a preparation method and application thereof. Background Art

[0002] Aneurysm is a common vascular disease, which is a local expansion caused by the weakness of the blood vessel wall. It usually occurs in the artery and can cause serious health problems such as bleeding or death if not treated in time. Aneurysm embolization is currently a major method for treating aneurysms. Its purpose is to block the aneurysm so that it no longer expands or ruptures. Liquid embolization surgery is currently a development direction for embolizing aneurysms. There have been many studies at home and abroad on the use of fiber optic catheters to inject liquid embolic materials into the aneurysm cavity and then perform photocuring. However, the existing fiber optic catheters have deficiencies in light transmission efficiency and uniformity, resulting in unsatisfactory curing effects for liquid embolic materials. Therefore, how to improve the light transmission efficiency and uniformity of fiber optic catheters has become a difficult problem in this field. Summary of the Invention

[0003] The object of the present invention is to provide an optical fiber conduit and a preparation method and application thereof. The optical fiber conduit provided by the present invention has better light transmission efficiency and uniformity.

[0004] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0005] The present invention provides an optical fiber catheter, comprising a catheter and an optical fiber; the optical fiber is bonded to the outer wall of the catheter along the length direction of the catheter by a medical adhesive; the inner diameter of the catheter is 0.4 to 0.7 mm; the outer diameter of the catheter is 0.5 to 1 mm; the area 4 to 6 mm from one end of the optical fiber to the end is a light-emitting area; the outer surface of the optical fiber catheter and the inner surface of the catheter in the optical fiber catheter are coated with a catheter coating layer.

[0006] Preferably, the material of the catheter includes polyurethane, polytetrafluoroethylene or silicone.

[0007] Preferably, the optical fiber comprises a core, a cladding and a coating layer; the diameter of the core is 50-100 μm; the thickness of the cladding is 100-150 μm; and the thickness of the coating layer is 10-50 μm.

[0008] The present invention also provides a method for preparing the optical fiber catheter described in the above technical solution, comprising the following steps:

[0009] (1) mixing a first silicon source, water, ethanol, and a catalyst to perform gelation to obtain a gel;

[0010] (2) drying and sintering the gel obtained in step (1) in sequence to obtain a core precursor;

[0011] (3) depositing a cladding on the surface of the core precursor obtained in step (2) by chemical vapor deposition and then drawing the core to obtain a core containing the cladding; the raw materials for the chemical vapor deposition include a second silicon source, oxygen and a carrier gas;

[0012] (4) coating the surface of the fiber core containing the cladding obtained in step (3) with a resin material to obtain an optical fiber precursor;

[0013] (5) coating or frosting one end of the optical fiber precursor obtained in step (4) to obtain an optical fiber;

[0014] (6) sequentially extruding and heat-treating the raw materials of the catheter to obtain the catheter;

[0015] (7) bonding the optical fiber obtained in step (5) to the outer wall of the catheter obtained in step (6) using a medical adhesive to obtain a catheter containing an optical fiber;

[0016] (8) Coating the outer surface and inner surface of the catheter containing the optical fiber obtained in step (7) with a resin material to obtain an optical fiber catheter.

[0017] Preferably, in step (1), the molar ratio of the first silicon source, water, ethanol and catalyst is 1:(3-5):(5-6):(0.01-0.02).

[0018] Preferably, the sintering in step (2) includes a first sintering, a second sintering and a third sintering performed in sequence; the temperature of the first sintering is 280-320°C, and the time of the first sintering is 1-3 hours; the temperature of the second sintering is 800-1000°C, and the time of the second sintering is 3-5 hours; the temperature of the third sintering is 1200-1400°C, and the time of the third sintering is 2-6 hours.

[0019] Preferably, in step (3), the flow rate of the second silicon source is 100-500 sccm, the flow rate of oxygen is 200-1000 sccm, and the flow rate of the carrier gas is 100-500 sccm.

[0020] Preferably, the extrusion molding temperature in step (6) is 180-220°C.

[0021] Preferably, the heat treatment temperature in step (6) is 150-200° C., and the heat treatment time is 1-3 hours.

[0022] The present invention also provides the optical fiber catheter described in the above technical solution or the optical fiber catheter prepared by the preparation method described in the above technical solution for use in interventional treatment instruments.

[0023] The present invention provides a fiber optic catheter comprising a catheter and an optical fiber; the optical fiber is bonded to the outer wall of the catheter along its length using a medical adhesive; the inner diameter of the catheter is 0.4 to 0.7 mm; the outer diameter of the catheter is 0.5 to 1 mm; the region 4 to 6 mm from one end of the optical fiber to the distal end is a light-emitting region; and the outer surface of the fiber optic catheter and the inner surface of the inner conduit are coated with a catheter coating. The present invention utilizes a catheter with specific inner and outer diameters to simultaneously improve the optical transmission efficiency and light uniformity of the optical fiber catheter. Results from the examples show that the optical fiber catheter provided by the present invention has a light transmission efficiency of 92% and a light uniformity of 90%. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 This is a schematic structural diagram of the optical fiber catheter provided by the present invention. DETAILED DESCRIPTION

[0025] The present invention provides an optical fiber catheter, comprising a catheter and an optical fiber; the optical fiber is bonded to the outer wall of the catheter along the length direction of the catheter by a medical adhesive; the inner diameter of the catheter is 0.4 to 0.7 mm; the outer diameter of the catheter is 0.5 to 1 mm; the area 4 to 6 mm from one end of the optical fiber to the end is a light-emitting area; the outer surface of the optical fiber catheter and the inner surface of the catheter in the optical fiber catheter are coated with a catheter coating layer.

[0026] The optical fiber catheter provided by the present invention includes a catheter.

[0027] In the present invention, the inner diameter of the catheter is 0.4-0.7 mm. As an embodiment, the inner diameter of the catheter can be specifically 0.4 mm, 0.5 mm, 0.6 mm or 0.7 mm.

[0028] In the present invention, the outer diameter of the conduit is 0.5 to 1 mm. As an embodiment, the outer diameter of the conduit can be 0.5 mm, 0.6 mm, 0.7 mm, 0.8 mm, 0.9 mm, or 1 mm. The present invention utilizes conduits with these inner and outer diameters to simultaneously improve the optical transmission efficiency and luminous uniformity of the optical fiber conduit.

[0029] In the present invention, the material of the catheter preferably includes polyurethane, polytetrafluoroethylene or silicone. The present invention uses a catheter made of the above materials to make the optical fiber catheter have better flexibility and bending resistance.

[0030] The optical fiber catheter provided by the present invention also includes an optical fiber.

[0031] In the present invention, the number of the optical fiber is preferably one.

[0032] In the present invention, the optical fiber preferably includes a core, a cladding and a coating.

[0033] In the present invention, the diameter of the fiber core is preferably 50 to 100 μm. As an embodiment, the diameter of the fiber core can be specifically 50 μm, 60 μm, 70 μm, 80 μm, 90 μm or 100 μm.

[0034] In the present invention, the thickness of the cladding layer is preferably 100 to 150 μm. In one embodiment, the thickness of the cladding layer may be 100 μm, 110 μm, 120 μm, 130 μm, 140 μm or 150 μm.

[0035] In the present invention, the thickness of the coating layer is preferably 10 to 50 μm. As an embodiment, the thickness of the coating layer can be specifically 10 μm, 20 μm, 30 μm, 40 μm or 50 μm.

[0036] In the present invention, the area 4 to 6 mm from one end of the optical fiber to the end is the light-emitting area, and preferably the area 5 mm from the end is the light-emitting area.

[0037] In the present invention, the optical fiber is bonded to the outer wall of the catheter along the length direction of the catheter by a medical adhesive.

[0038] In the present invention, the medical adhesive is preferably a medical polyurethane adhesive.

[0039] The present invention has no special limitation on the length of the optical fiber conduit, and the length can be selected according to actual needs.

[0040] In the present invention, the outer surface of the optical fiber conduit and the inner surface of the conduit in the optical fiber conduit are coated with a conduit coating layer.

[0041] In the present invention, the material of the catheter coating is preferably polyvinyl pyrrolidone, polyacrylamide or polyurethane; the thickness of the catheter coating is preferably 2 to 5 μm. In the present invention, the catheter coating can make other substances pass through the optical fiber catheter more smoothly.

[0042] The present invention adopts a catheter with specific inner and outer diameters, thereby improving the light transmission efficiency and luminous uniformity of the optical fiber catheter and controlling the material of the catheter so that the optical fiber catheter has good flexibility and bending resistance.

[0043] The structural diagram of the optical fiber catheter provided by the present invention is as follows Figure 1 shown.

[0044] The present invention also provides a method for preparing the optical fiber catheter described in the above technical solution, comprising the following steps:

[0045] (1) mixing a first silicon source, water, ethanol, and a catalyst to perform gelation to obtain a gel;

[0046] (2) drying and sintering the gel obtained in step (1) in sequence to obtain a core precursor;

[0047] (3) depositing a cladding on the surface of the core precursor obtained in step (2) by chemical vapor deposition and then drawing the core to obtain a core containing the cladding; the raw materials for the chemical vapor deposition include a second silicon source, oxygen and a carrier gas;

[0048] (4) coating the surface of the fiber core containing the cladding obtained in step (3) with a resin material to obtain an optical fiber precursor;

[0049] (5) coating or frosting one end of the optical fiber precursor obtained in step (4) to obtain an optical fiber;

[0050] (6) sequentially extruding and heat-treating the raw materials of the catheter to obtain the catheter;

[0051] (7) bonding the optical fiber obtained in step (5) to the outer wall of the catheter obtained in step (6) using a medical adhesive to obtain a catheter containing an optical fiber;

[0052] (8) Coating the outer surface and inner surface of the catheter containing the optical fiber obtained in step (7) with a resin material to obtain an optical fiber catheter.

[0053] Unless otherwise specified, the present invention has no particular limitation on the sources of the raw materials, and commercially available products known to those skilled in the art may be used.

[0054] The present invention mixes a first silicon source, water, ethanol and a catalyst, and performs gelation to obtain a gel.

[0055] In the present invention, the first silicon source is preferably tetraethoxysilane or tetramethoxysilane.

[0056] In the present invention, the water is preferably deionized water.

[0057] In the present invention, the catalyst preferably includes acid solution or alkali solution; the acid solution is preferably hydrochloric acid; the concentration of the hydrochloric acid is preferably 0.01 to 0.1 mol / L; the alkali solution is preferably ammonia water; the concentration of the ammonia water is preferably 0.01 to 0.1 mol / L.

[0058] In the present invention, the molar ratio of the first silicon source, water, ethanol, and catalyst is preferably 1:(3-5):(5-6):(0.01-0.02), and more preferably 1:4:6:0.01. By controlling the amount of each raw material within the above range, the first silicon source can be fully hydrolyzed.

[0059] In the present invention, the mixing of the first silicon source, water, ethanol and catalyst is preferably as follows: water and ethanol are mixed at 20-25° C., stirred at 400-600 rpm, the first silicon source is added, stirring is continued for 30-60 minutes, and the catalyst is added.

[0060] In the present invention, the gelation temperature is preferably room temperature, and the gelation time is preferably 24 to 48 hours. In one embodiment, the gelation time can be specifically 24 hours, 26 hours, 28 hours, 30 hours, 35 hours, 40 hours, 45 hours, or 48 hours. By controlling the gelation time within the above range, the present invention can fully form a gel.

[0061] After obtaining the gel, the present invention sequentially dries and sinters the gel to obtain a fiber core.

[0062] In the present invention, the drying preferably includes atmospheric pressure drying or supercritical drying.

[0063] In the present invention, the atmospheric pressure drying temperature is preferably 50 to 200°C; and the atmospheric pressure drying time is preferably 45 to 50 hours. As an embodiment, the atmospheric pressure drying temperature can be specifically 50°C, 100°C, 150°C, or 200°C; and the atmospheric pressure drying time can be specifically 45 hours, 46 hours, 47 hours, 48 ​​hours, 49 hours, or 50 hours.

[0064] In the present invention, the supercritical drying is preferably supercritical carbon dioxide drying. The present invention has no particular limitation on the operation of the supercritical carbon dioxide drying, and the solvent in the gel can be fully removed using the supercritical carbon dioxide drying technical solution well known to those skilled in the art.

[0065] In the present invention, the sintering preferably includes a first sintering, a second sintering and a third sintering performed sequentially.

[0066] In the present invention, the first sintering temperature is preferably 280-320°C, more preferably 300°C; the first sintering time is preferably 1-3 hours, more preferably 2 hours; the heating rate to the first sintering temperature is preferably 4-6°C / min, more preferably 5°C / min.

[0067] In the present invention, the second sintering temperature is preferably 800-1000°C; the second sintering time is preferably 3-5 hours; and the heating rate to the second sintering temperature is preferably 2-5°C / min. As an embodiment, the second sintering temperature can be specifically 800°C, 900°C, or 1000°C; the second sintering time can be specifically 3 hours, 4 hours, or 5 hours; and the heating rate to the second sintering temperature can be specifically 2°C / min, 3°C / min, 4°C / min, or 5°C / min.

[0068] In the present invention, the temperature of the third sintering step is preferably 1200-1400°C; the duration of the third sintering step is preferably 2-6 hours; and the heating rate to the third sintering temperature is preferably 2-6°C / min. In one embodiment, the temperature of the third sintering step may be 1200°C, 1300°C, or 1400°C; the duration of the third sintering step may be 2 hours, 3 hours, 4 hours, 5 hours, or 6 hours; and the heating rate to the third sintering temperature may be 2°C / min, 3°C / min, 4°C / min, 5°C / min, or 6°C / min. In the present invention, during the sintering process, the gel fully reacts to form silica as the core material. By controlling the sintering parameters within the aforementioned range, the present invention enables the gel to fully vitrify to form silica, further improving the optical transmission performance of the optical fiber conduit.

[0069] After sintering is completed, the present invention preferably cools the sintered product to obtain a core precursor.

[0070] The present invention has no special limitation on the cooling operation, and cooling to room temperature can be performed using cooling technical solutions well known to those skilled in the art.

[0071] In the present invention, the core precursor is preferably cylindrical. The present invention has no special requirements on the size of the core precursor, as long as the diameter of the core after subsequent drawing is within the required range.

[0072] After obtaining the fiber core precursor, the present invention deposits a cladding on the surface of the fiber core precursor by chemical vapor deposition and then draws the fiber core to obtain the fiber core containing the cladding.

[0073] In the present invention, the raw materials for chemical vapor deposition preferably include a second silicon source, oxygen and a carrier gas.

[0074] In the present invention, the second silicon source is preferably silicon tetrachloride; and the carrier is preferably argon or nitrogen.

[0075] In the present invention, the flow rate of the second silicon source is preferably 100 to 500 sccm; the flow rate of the oxygen gas is preferably 200 to 1000 sccm; and the flow rate of the carrier gas is preferably 100 to 500 sccm. In one embodiment, the flow rate of the second silicon source may be specifically 100 sccm, 200 sccm, 300 sccm, 400 sccm, or 500 sccm; the flow rate of the oxygen gas may be specifically 200 sccm, 500 sccm, 600 sccm, 800 sccm, or 1000 sccm; and the flow rate of the carrier gas may be specifically 100 sccm, 200 sccm, 300 sccm, 400 sccm, or 500 sccm.

[0076] In the present invention, the chemical vapor deposition raw material preferably further includes a dopant; the dopant preferably includes silicon tetrafluoride or germanium tetrachloride. The fluorine or germanium doping of the present invention can reduce light propagation loss and further improve the light transmission efficiency of the optical fiber conduit.

[0077] In the present invention, the flow rate of the dopant is preferably 50 to 200 sccm. As an embodiment, the flow rate of the dopant can be specifically 50 sccm, 80 sccm, 100 sccm, 150 sccm or 200 sccm.

[0078] In the present invention, the chemical vapor deposition temperature is preferably 1400-1700°C; the chemical vapor deposition pressure is preferably 100-500 Torr. As an embodiment, the chemical vapor deposition temperature can be specifically 1400°C, 1500°C, 1600°C, or 1700°C; the chemical vapor deposition pressure can be specifically 100 Torr, 200 Torr, 300 Torr, 400 Torr, or 500 Torr. The present invention does not specifically limit the chemical vapor deposition time, as long as the cladding thickness is within the required range.

[0079] In the present invention, the core precursor is preferably rotated at a constant speed during the chemical vapor deposition process. This constant rotation of the core precursor ensures a uniform cladding distribution. The present invention does not specifically limit the rotation speed; a speed familiar to those skilled in the art can be used to ensure uniform cladding distribution. By controlling the chemical vapor deposition parameters within the aforementioned ranges, the present invention can further improve the optical transmission efficiency and luminescence uniformity of the optical fiber conduit.

[0080] After the chemical vapor deposition is completed, the present invention preferably performs a heat treatment on the chemical vapor deposition product before drawing.

[0081] In the present invention, the heat treatment temperature is preferably 1100-1400°C, and the heat treatment duration is preferably 1-3 hours. In one embodiment, the heat treatment temperature can be 1100°C, 1200°C, 1300°C, or 1400°C, and the heat treatment duration can be 1 hour, 2 hours, or 3 hours. In the present invention, the heat treatment is used to remove residual chlorides and increase cladding density.

[0082] In the present invention, the drawing temperature is preferably 2000-2200°C; the drawing rate is preferably 1-5 m / min. As an embodiment, the drawing temperature may be specifically 2000°C, 2100°C, or 2200°C; and the drawing rate is preferably 1 m / min, 2 m / min, 3 m / min, 4 m / min, or 5 m / min.

[0083] The present invention has no special limitation on the drawing time, as long as the dimensions of the core and cladding after drawing are within the required range.

[0084] After obtaining the fiber core containing the cladding, the present invention coats the surface of the fiber core containing the cladding with a resin material to obtain an optical fiber precursor.

[0085] In the present invention, the resin material is preferably polyurethane; the molecular weight of the polyurethane is preferably 40,000 to 60,000, more preferably 50,000.

[0086] The present invention has no special limitation on the coating operation. A coating technical solution well known to those skilled in the art may be adopted to ensure the thickness and uniformity of the coating layer.

[0087] After coating is completed, the present invention preferably solidifies the coated product to obtain an optical fiber precursor.

[0088] In the present invention, the curing temperature is preferably 60 to 80° C., more preferably 70° C.; the curing time is preferably 2 to 4 hours, more preferably 3 hours.

[0089] After obtaining the optical fiber precursor, the present invention coats or frosts one end of the optical fiber precursor to obtain the optical fiber. The present invention coats or frosts the optical fiber precursor to form a light-emitting area.

[0090] In the present invention, the optical fiber precursor is preferably cleaned before use. The present invention has no particular limitation on the cleaning operation, as long as the surface of the optical fiber precursor is kept clean.

[0091] In the present invention, the coating is preferably performed by plasma enhanced chemical vapor deposition.

[0092] In the present invention, the plasma enhanced chemical vapor deposition gas preferably includes trimethylaluminum and oxygen; the flow rate of the trimethylaluminum is preferably 9-11 sccm, more preferably 10 sccm; the flow rate of the oxygen is preferably 18-22 sccm, more preferably 20 sccm.

[0093] In the present invention, the temperature of the plasma-enhanced chemical vapor deposition is preferably 50-100°C; the pressure of the plasma-enhanced chemical vapor deposition is preferably 0.01-0.1 Torr; the radio frequency power of the plasma-enhanced chemical vapor deposition is preferably 280-320 W, more preferably 300 W; and the deposition rate of the plasma-enhanced chemical vapor deposition is preferably 0.1-0.3 nm / s. The present invention does not specifically limit the time of the plasma-enhanced chemical vapor deposition, as long as the thickness of the coating is within the desired range.

[0094] In the present invention, the thickness of the coating is preferably 0.1 to 2 μm. Controlling the coating thickness and coating parameters within the above range can ensure uniform light distribution and avoid excessive reflection, further improving the light transmission efficiency and luminous uniformity of the optical fiber conduit.

[0095] After the plasma enhanced chemical vapor deposition is completed, the present invention preferably performs a heat treatment on the product of the plasma enhanced chemical vapor deposition.

[0096] In the present invention, the temperature of the heat treatment is preferably 120-160° C., more preferably 150° C.; the time of the heat treatment is preferably 0.5-1.5 h, more preferably 1 h. In the present invention, the heat treatment is used to improve the stability of the coating.

[0097] In the present invention, the frosting treatment is preferably performed by polishing the optical fiber precursor with sandpaper or performing sandblasting treatment on the optical fiber precursor.

[0098] In the present invention, the mesh number of the sandpaper is preferably ≥1000 mesh; the frosting depth after the sandpaper is sanded is preferably 0.1-1 μm. The present invention has no special restrictions on other operations of the sandpaper sanding, as long as the frosting depth is within the above range.

[0099] In the present invention, the abrasive during the sandblasting treatment is preferably glass beads or aluminum oxide; the particle size of the abrasive is preferably 5 to 50 μm; the average roughness (R a ) is preferably 0.2 to 0.8 μm; the root mean square roughness (R q ) is preferably 0.3 to 1 μm; the maximum peak-to-valley height after sandblasting (R z ) is preferably 1 to 5 μm. The present invention does not specifically limit other operations of the sandblasting process; sandblasting techniques familiar to those skilled in the art may be employed. By sandblasting the optical fiber precursor and controlling the parameters within the aforementioned ranges, the present invention can further improve the uniform distribution of light.

[0100] The present invention sequentially performs extrusion molding and heat treatment on raw materials of the catheter to obtain the catheter.

[0101] In the present invention, the raw material of the catheter includes polyurethane, polytetrafluoroethylene or silicone.

[0102] In the present invention, the molecular weight (M W ) is preferably 50,000 to 100,000; the molecular weight of the polytetrafluoroethylene (M W ) is preferably 100,000 to 500,000; the molecular weight of the silica gel (M W) is preferably 100000 to 200000. The present invention uses the above molecular weight raw materials to make the catheter have excellent flexibility, reducing the difficulty and risk of operating the optical fiber catheter during use.

[0103] In the present invention, the extrusion molding temperature is preferably 180-220°C; the cooling rate during extrusion molding is preferably 1-2°C / s. Controlling the cooling rate within this range ensures a smooth, bubble-free catheter surface. The present invention does not specifically limit the other extrusion molding operations; it is sufficient to employ extrusion molding techniques familiar to those skilled in the art to ensure that the catheter dimensions are within the desired range.

[0104] In the present invention, the heat treatment temperature is preferably 150-200° C. and the heat treatment time is preferably 1-3 hours. The present invention performs heat treatment to enhance the mechanical properties and wear resistance of the catheter.

[0105] After obtaining the catheter and the optical fiber, the present invention adheres the optical fiber to the outer wall of the catheter through a medical adhesive to obtain the catheter containing the optical fiber.

[0106] The present invention has no particular limitation on the amount of the medical adhesive, as long as it can firmly bond the optical fiber to the outer wall of the catheter.

[0107] After bonding is completed, the present invention preferably solidifies the bonded product to obtain a catheter containing an optical fiber.

[0108] In the present invention, the curing temperature is preferably 60 to 80° C.; and the curing time is preferably 1 to 2 hours.

[0109] After obtaining the optical fiber-containing catheter, the present invention coats the outer surface and the inner surface of the catheter containing the optical fiber with resin material to obtain the optical fiber catheter.

[0110] In the present invention, the resin material is preferably polyvinyl pyrrolidone, polyacrylamide or polyurethane, and the molecular weight (M W ) is preferably 100,000 to 300,000.

[0111] The present invention has no particular limitation on the coating method. A coating technical solution well known to those skilled in the art can be used to ensure that the thickness of the catheter coating layer is within a desired range.

[0112] After coating is completed, the present invention preferably solidifies the coated product to obtain an optical fiber conduit.

[0113] In the present invention, the curing temperature is preferably 80-100° C.; the curing time is preferably 2-4 hours.

[0114] The present invention controls various parameters during the preparation of the optical fiber catheter, improves the light transmission efficiency and luminous uniformity of the optical fiber catheter, and simultaneously improves the flexibility and bending resistance of the optical fiber catheter, thereby reducing the difficulty and risk of operation when the optical fiber catheter is used.

[0115] The present invention also provides the optical fiber catheter described in the above technical solution or the optical fiber catheter prepared by the preparation method described in the above technical solution for use in interventional treatment instruments.

[0116] In the present invention, the interventional treatment device is preferably an aneurysm embolization treatment device.

[0117] In the present invention, when the optical fiber catheter is used, the light source is preferably connected to the optical fiber catheter via an optical fiber connector.

[0118] In the present invention, the light source is preferably an ultraviolet light emitting diode; the wavelength of the light source is preferably 365 to 405 nm; and the power of the light source is preferably 3 to 30 W.

[0119] In the present invention, during the application process, liquid embolic material is injected into the aneurysm cavity through a catheter, and then the liquid embolic material is solidified by emitting light through an optical fiber, thereby completing aneurysm embolization.

[0120] The present invention has no special limitation on other operations during the application, and the application technical solutions familiar to those skilled in the art can be adopted.

[0121] The optical fiber catheter of the present invention has excellent light transmission efficiency and luminous uniformity as well as flexibility and bending resistance, and has a better embolization effect when used for aneurysm embolization.

[0122] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions of the present invention. Obviously, the embodiments described are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0123] Example 1

[0124] An optical fiber catheter, consisting of a catheter and an optical fiber;

[0125] The optical fiber is bonded to the outer wall of the catheter along the length direction of the catheter by a medical polyurethane adhesive;

[0126] The inner diameter of the catheter is 0.43 mm; the outer diameter of the catheter is 0.6 mm;

[0127] The area 5mm from one end of the optical fiber to the end is the light-emitting area; the optical fiber consists of a core, a cladding and a coating layer, the diameter of the core is 50μm, the thickness of the cladding is 100μm, and the thickness of the coating layer is 10μm;

[0128] The outer surface of the optical fiber conduit and the inner surface of the conduit in the optical fiber conduit are coated with a conduit coating layer, the conduit coating layer is made of polyacrylamide and has a thickness of 3 μm;

[0129] The preparation method of the optical fiber catheter is as follows:

[0130] (1) Deionized water and ethanol were mixed at 20°C, stirred at 500 rpm, tetraethoxysilane was added, and stirring was continued for 60 minutes. Then, 0.01 mol / L hydrochloric acid was added. The molar ratio of tetraethoxysilane, deionized water, ethanol and hydrochloric acid was 1:4:6:0.01. The mixture was gelled at room temperature for 24 hours to obtain a gel.

[0131] (2) The gel was dried at 100°C under normal pressure for 48 h, then heated to 300°C at 5°C / min and sintered for 2 h, then heated to 800°C at 2°C / min and sintered for 4 h, and finally heated to 1200°C at 2°C / min and sintered for 2 h to obtain a cylindrical fiber core precursor;

[0132] (3) depositing a cladding on the surface of the core precursor obtained in step (2) by chemical vapor deposition, wherein the raw materials for chemical vapor deposition are silicon tetrachloride, oxygen and argon, the flow rate of silicon tetrachloride is 500 sccm, the flow rate of oxygen is 600 sccm, the flow rate of argon is 300 sccm, the temperature of chemical vapor deposition is 1500°C, and the pressure is 300 Torr. During the chemical vapor deposition process, the core precursor rotates at a constant speed; after the chemical vapor deposition is completed, heat treatment is performed at 1200°C for 1 hour, and then drawing is performed at 2000°C to obtain a core containing a cladding, and the drawing rate is 3 m / min;

[0133] (4) spraying polyurethane resin (molecular weight 50,000) on the surface of the fiber core containing the cladding obtained in step (3) and curing it at 70° C. for 3 hours to obtain an optical fiber precursor;

[0134] (5) Cleaning the surface of the optical fiber precursor, performing plasma-enhanced chemical vapor deposition on the light-emitting area 5 mm from the top of one end of the optical fiber precursor, the reaction gas consists of trimethylaluminum and oxygen, the flow rate of trimethylaluminum is 10 sccm, the flow rate of oxygen is 20 sccm, the temperature is 100°C, the pressure is 0.1 Torr, the RF power is 300 W, the deposition rate is 0.1 nm / s, the coating thickness is 0.1 μm, and after plasma-enhanced chemical vapor deposition, heat treatment is performed at 150°C for 1 h to obtain an optical fiber;

[0135] (6) Polytetrafluoroethylene (MW The extrusion molding was carried out at 200°C with a cooling rate of 2°C / s, and then heat-treated at 150°C for 2h to obtain a catheter;

[0136] (7) bonding the optical fiber obtained in step (5) to the outer wall of the catheter obtained in step (6) using a medical polyurethane adhesive and curing at 70° C. for 1 hour to obtain a catheter containing an optical fiber;

[0137] (8) The outer surface and inner surface of the catheter containing the optical fiber obtained in step (7) are coated with a resin material (polyacrylamide, molecular weight of 40,000), and cured at 80° C. for 2 hours to obtain an optical fiber catheter.

[0138] The optical fiber conduit prepared in Example 1 has a light transmission efficiency of 92%, a light emission uniformity of 90%, a bending strength of 80 MPa, and a minimum bending radius that can be supported is 1.0 cm.

[0139] Comparative Example 1

[0140] The inner diameter of the catheter in Example 1 was replaced with 0.95 mm, the outer diameter of the catheter was replaced with 1.10 mm, and other parameters were the same as those in Example 1 to obtain an optical fiber catheter.

[0141] The optical fiber conduit of Comparative Example 1 has a light transmission efficiency of 80% and a light emission uniformity of 50%.

[0142] In summary, the present invention enables the optical fiber conduit to have better light transmission efficiency and light emission uniformity by selecting a conduit with specific inner and outer diameters.

[0143] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as within the scope of protection of the present invention.

Claims

1. A fiber optic catheter comprising a catheter and an optical fiber; the optical fiber is bonded to the outer wall of the catheter along the length of the catheter using a medical adhesive; the inner diameter of the catheter is 0.4 to 0.7 mm; the outer diameter of the catheter is 0.5 to 1 mm; the area 4 to 6 mm from one end of the optical fiber to the distal end is a light-emitting area; and the outer surface of the optical fiber catheter and the inner surface of the catheter in the optical fiber catheter are coated with a catheter coating.

2. The optical fiber catheter according to claim 1, wherein The material of the catheter includes polyurethane, polytetrafluoroethylene or silicone.

3. The optical fiber catheter according to claim 1, wherein The optical fiber comprises a core, a cladding and a coating layer; the diameter of the core is 50-100 μm; the thickness of the cladding is 100-150 μm; and the thickness of the coating layer is 10-50 μm.

4. The method for preparing the optical fiber catheter according to any one of claims 1 to 3, comprising the following steps: (1) mixing a first silicon source, water, ethanol, and a catalyst to perform gelation to obtain a gel; (2) drying and sintering the gel obtained in step (1) in sequence to obtain a core precursor; (3) depositing a cladding on the surface of the core precursor obtained in step (2) by chemical vapor deposition and then drawing the core to obtain a core containing the cladding; the raw materials for the chemical vapor deposition include a second silicon source, oxygen and a carrier gas; (4) coating the surface of the fiber core containing the cladding obtained in step (3) with a resin material to obtain an optical fiber precursor; (5) coating or frosting one end of the optical fiber precursor obtained in step (4) to obtain an optical fiber; (6) sequentially extruding and heat-treating the raw materials of the catheter to obtain the catheter; (7) bonding the optical fiber obtained in step (5) to the outer wall of the catheter obtained in step (6) using a medical adhesive to obtain a catheter containing an optical fiber; (8) Coating the outer surface and inner surface of the catheter containing the optical fiber obtained in step (7) with a resin material to obtain an optical fiber catheter.

5. The preparation method according to claim 4, characterized in that In the step (1), the molar ratio of the first silicon source, water, ethanol and catalyst is 1:(3-5):(5-6):(0.01-0.02).

6. The preparation method according to claim 4, characterized in that The sintering in step (2) includes a first sintering, a second sintering and a third sintering performed in sequence; the temperature of the first sintering is 280-320°C, and the time of the first sintering is 1-3 hours; the temperature of the second sintering is 800-1000°C, and the time of the second sintering is 3-5 hours; the temperature of the third sintering is 1200-1400°C, and the time of the third sintering is 2-6 hours.

7. The preparation method according to claim 4, characterized in that In the step (3), the flow rate of the second silicon source is 100-500 sccm, the flow rate of the oxygen is 200-1000 sccm, and the flow rate of the carrier gas is 100-500 sccm.

8. The preparation method according to claim 4, characterized in that The temperature of the extrusion molding in the step (6) is 180-220°C.

9. The preparation method according to claim 4, characterized in that The heat treatment temperature in step (6) is 150-200° C., and the heat treatment time is 1-3 hours.

10. The optical fiber catheter according to any one of claims 1 to 3 or the optical fiber catheter prepared by the preparation method according to any one of claims 4 to 9 is used in interventional therapy devices.

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