Cosmetic slow-release system, application and cosmetic

Abstract

The invention belongs to the field of new daily chemical materials, and discloses a cosmetic sustained-release system which comprises a film-forming agent and cosmetic effective components loaded in the film-forming agent, the film-forming agent is prepared from the following components in parts by weight: 0.002 to 0.3 part of anionic Tempo nano cellulose; 0.0005-1 part of a cationic raw material which can be applied to cosmetics; the anionic Tempo-modified nano cellulose is characterized in that the trade mark of the anionic Tempo-modified nano cellulose is any one of RHEOCRYSTA C-2SP, RHEOCRYSTA I-2SX, RHEOCRYSTA I-2AX and RHEOCRYSTA I-2SXS, and the trade mark of the anionic Tempo-modified nano cellulose is any one of RHEOCRYSTA C-2SP, RHEOCRYSTA I- The film-forming agent in the sustained-release system exists in the form of a dispersive nanofiber membrane, has contractility, provides instant compact film-forming feeling, and is comfortable to use, good in skin-friendly property and good in spreadability. Meanwhile, the effective components of the cosmetics can be slowly released into the skin after the film-forming agent forms a film, so that the functions of protecting the skin and the hair are realized. The cosmetic active ingredients are loaded in the nanofiber membrane, so that the cationic raw materials and the cosmetic active ingredients are released at the same time, and the skin care and hair care effects can be further improved.

Description

Technical Field

[0001] The present invention relates to the field of new daily chemical materials, and in particular to a cosmetic sustained-release system, uses and cosmetics. Background Art

[0002] Sustained-release technology is widely used in the cosmetics field and plays an important role. Sustained-release technology is a method of encapsulating active ingredients and then slowing their release over a certain period of time to maintain a certain effective concentration within the system.

[0003] Many active ingredients in the cosmetics field are not resistant to high temperatures, light, acid and alkali, are easily oxidized, are more active and easily inactivated. Sustained-release technology can be used to encapsulate them and then control their release to improve the utilization of the active ingredients.

[0004] Depending on whether the sustained-release component reacts chemically with the sustained-release agent, it can be divided into physical sustained-release and chemical sustained-release. Physical sustained-release means that the sustained-release component is physically wrapped by the sustained-release agent, while chemical sustained-release is achieved through chemical bonding.

[0005] The sustained-release technology in this field is usually physical sustained-release, and the carrier is in the form of porous solid materials, capsules, microspheres, liposomes, etc. There is room for further improvement in the utilization of active ingredients.

[0006] In this field, porous solid materials, capsules, microspheres, liposomes, etc. are usually used as sustained-release carriers. These carriers have complex production processes, low loading capacity, are easily degraded by the skin, and are high in cost, which limits the utilization and application of active ingredients.

[0007] In this field, we hope that the sustained-release carrier body should be multifunctional to reduce product costs and improve product functionality. Summary of the Invention

[0008] The present invention aims to provide a cosmetic sustained-release system comprising a film-forming agent and a cosmetic active ingredient. The film-forming agent is present in the form of a dispersed nanofiber film, exhibiting contractile force and providing an immediate, firm film-forming feel. The film-forming agent also allows for a comfortable feel, excellent skin affinity, and good spreadability. Simultaneously, after film formation, the cosmetic active ingredient can be sustained-released into the skin, achieving both skin and hair care benefits. By loading the cosmetic active ingredient into the nanofiber film, the present invention achieves simultaneous release of the cationic raw material and the cosmetic active ingredient, further enhancing the skin and hair care effects.

[0009] At the same time, the present invention also provides a use of the cosmetic sustained-release system and cosmetics.

[0010] To achieve the above objectives, this application discloses:

[0011] A cosmetic sustained-release system, comprising a film-forming agent and a cosmetic active ingredient loaded in the film-forming agent;

[0012] The film-forming agent comprises the following components in parts by weight:

[0013] Anionic Tempo nanocellulose 0.002-0.3 parts;

[0014] 0.0005 to 1 part of cationic raw materials that can be used in cosmetics;

[0015] The brand of the anionic Tempo nanocellulose is any one of RHEOCRYSTA C-2SP, RHEOCRYSTA I-2SX, RHEOCRYSTA I-2AX, and RHEOCRYSTA I-2SXS.

[0016] High-density carboxyl groups are introduced into the nanocellulose produced by Tempo technology. The fiber width is about 3nm, which is characterized by very fine and uniform fiber width, and can expose more anionic carboxyl groups. Compared with ordinary cellulose, when combined with cationic raw materials, opposite charges attract each other, and the attraction and repulsion are balanced to form a nanofiber membrane. In addition to having a firm and uniform film-forming property, this nanofiber membrane, when loaded with cosmetic active ingredients, controls the release of cosmetic active ingredients through a dual sustained release method of physical and chemical sustained release, thereby improving the utilization and delivery rate of cosmetic active ingredients.

[0017] In the above-mentioned cosmetic sustained-release system, the cosmetic active ingredients are active ingredients for skin whitening, active ingredients for skin anti-wrinkle, active ingredients for anti-allergy, active ingredients for preventing hair loss, active ingredients for skin acne treatment, active ingredients for skin nourishment, active ingredients for skin repair, active ingredients for skin firming, active ingredients for skin soothing, active ingredients for skin oil control, active ingredients for skin exfoliation, active ingredients for preventing hair breakage, active ingredients for body refreshing, active ingredients for scalp anti-dandruff, active ingredients for skin moisturizing, and active ingredients for hair care.

[0018] In the above-mentioned cosmetic sustained-release system, the cosmetic active ingredients are one or more combinations of acetyl hexapeptide-8, tripeptide-1 copper, dipotassium glycyrrhizate, panthenol, tranexamic acid, citrus fruit extract, sanguisorba officinalis root extract, withania somnifera root extract, niacinamide, tetrapeptide-1, ergothioneine, arborvitae leaf extract, acetyl tetrapeptide-3, piroctone olamine salt, hexamidine di(hydroxyethylsulfonic acid) salt, hydrolyzed collagen, PCA zinc, and lactobionic acid.

[0019] In the above-mentioned cosmetic sustained-release system, the amount of each active ingredient added independently is:

[0020] Tripeptide-1 copper 0.0001-1 part;

[0021] Ergothioneine 0.0001-1 part;

[0022] Acetyl hexapeptide-8 0.000005-0.0025 parts.

[0023] In the above-mentioned cosmetic sustained-release system, the cationic raw material is one or more combinations of carboxymethyl chitosan, sodium DNA, hydroxypropyltrimethylammonium chloride hyaluronic acid, basic amino acids, and dipeptide diaminobutyryl benzylamide diacetate.

[0024] In the above-mentioned cosmetic sustained-release system, the molecular weight of the carboxymethyl chitosan is 5KDa to 50KDa; the molecular weight of the sodium DNA is 200KDa to 800KDa; the molecular weight of the hydroxypropyltrimethylammonium chloride hyaluronic acid is 400KDa to 1000KDa; and the basic amino acid is one or more combinations of lysine, arginine, and histidine.

[0025] In the above-mentioned cosmetic sustained-release system, the molecular weight of the carboxymethyl chitosan is 10KDa to 30KDa; the molecular weight of the sodium DNA is 300KDa to 600KDa; and the molecular weight of the hydroxypropyltrimethylammonium chloride hyaluronic acid is 500KDa to 800KDa.

[0026] In the above-mentioned cosmetic sustained-release system, if the cationic raw material is carboxymethyl chitosan, the amount of the cationic raw material is 0.02 to 0.5 parts;

[0027] If the cationic raw material is sodium DNA, the amount of the cationic raw material is 0.0005 to 0.05 parts;

[0028] If the cationic raw material is hydroxypropyltrimonium chloride hyaluronic acid, the amount of the cationic raw material is 0.01 to 1 part;

[0029] If the cationic raw material is a basic amino acid, the amount of the cationic raw material used is 0.001 to 0.1 parts.

[0030] In the above-mentioned cosmetic sustained-release system, the film-forming agent further comprises 0.05 to 5 parts of hydrolyzed corn starch.

[0031] At the same time, the present invention also discloses the use of any of the above-mentioned cosmetic sustained-release systems in preparing cosmetics.

[0032] Finally, the present invention also discloses a cosmetic, which is added with 0.0025 to 15 wt% of any of the above-mentioned cosmetic sustained-release systems.

[0033] This application has at least the following beneficial effects:

[0034] 1. The nanocellulose produced by Tempo technology introduces high-density carboxyl groups, with a fiber width of approximately 3nm. It has the characteristics of very fine and uniform fiber width, which can expose more anionic carboxyl groups. Compared with ordinary cellulose, when combined with cationic raw materials, opposite charges attract each other, and the attraction and repulsion are balanced to form a nanofiber membrane. In addition to having a firm and uniform film-forming property, this nanofiber membrane, when loaded with cosmetic active ingredients, controls the release of cosmetic active ingredients through a dual sustained release method of physical and chemical sustained release, thereby improving the utilization and delivery rate of cosmetic active ingredients.

[0035] 2. The cationic raw materials used in the film-forming agent of the present invention and applicable to cosmetics refer to active ingredients with certain skin care, hair care and other effects in the field of cosmetics. After the film-forming agent of the present invention acts on the cosmetics, it can release the cationic raw materials it carries through the film, thereby achieving the effects of skin care and hair care.

[0036] 3. The active ingredients of cosmetics can be slowly released into the skin after the film-forming agent forms a film, achieving the functions of skin care and hair care.

[0037] 4. The present invention achieves the simultaneous release of cationic raw materials and cosmetic active ingredients by loading cosmetic active ingredients in the nanofiber membrane, which can further improve the skin care and hair care effects. BRIEF DESCRIPTION OF THE DRAWINGS

[0038] Figure 1 is an OM image of a thin film of Example;

[0039] Figure 2 is the OM image of the film of comparative example;

[0040] Figure 3 These are photographs showing the high-temperature film-forming performance of Examples and Comparative Examples. DETAILED DESCRIPTION

[0041] The present invention will be described clearly and completely below in conjunction with the examples of the present invention. In the description of the present invention, it should be noted that, where specific conditions are not specified in the examples, conventional conditions or conditions recommended by the manufacturer were used. Reagents or instruments used where the manufacturer is not specified are conventional products that can be purchased commercially.

[0042] Source of raw materials:

[0043] Anionic Tempo Nanocellulose: produced by Dai-ichi Kogyo Seiyaku Co., Ltd., brand: RHEOCRYSTAC-2SP.

[0044] Microcrystalline cellulose without oxidation treatment: German JRS Group; Brand: CS100S;

[0045] Carboxymethyl chitosan: Shanghai Chunlu Chemical Co., Ltd.; specifications include: 30KDa, 10KDa;

[0046] DNA sodium: Ruijiming (Shandong) Biotechnology Co., Ltd.; specifications include: 300KDa, 600KDa;

[0047] Hydroxypropyltrimonium chloride hyaluronic acid: Kewpie Co., Ltd.; specifications include: 500KDa, 800KDa;

[0048] Hydrolyzed corn starch: Dow Chemical (Shanghai) Co., Ltd.; brand: MaizeCare Clarity Polymer.

[0049] The following is divided into two parts, introducing film-forming agents and cosmetic sustained-release systems respectively.

[0050] Part I Film-Forming Agent

[0051] Example 1 to Example 14

[0052] For specific formula, please refer to Table 1 and Table 2;

[0053] Table 1 Formulation Unit: wt%

[0054]

[0055]

[0056] Table 2 Formulation Unit: wt%

[0057]

[0058]

[0059] The preparation methods of Examples 1 to 11 are as follows:

[0060] (1) Place deionized water and microcrystalline cellulose in a container, turn on the homogenizer, 2000-3000 rpm, homogenize for 3-5 minutes, mix evenly, and stir at 150-200 rpm for 3-5 minutes;

[0061] (2) Add the cationic raw material to step (1) and stir at 150-200 rpm for 5-10 minutes;

[0062] (3) Allow to stand to obtain a composition.

[0063] The preparation methods of Examples 12 to 14 are as follows:

[0064] (1) Place deionized water and microcrystalline cellulose in a container, turn on the homogenizer, 2000-3000 rpm, homogenize for 3-5 minutes, mix evenly, and stir at 150-200 rpm for 3-5 minutes;

[0065] (2) Add the cationic raw material to step (1) and stir at 150-200 rpm for 5-10 minutes;

[0066] (3) Add hydrolyzed corn starch to step (2) and stir at 150-200 rpm for 5-10 minutes;

[0067] (4) Allow to stand to obtain a composition.

[0068] Comparative Example 1 to Comparative Example 12

[0069] For specific formulas, please refer to Table 3 and Table 4;

[0070] Table 3 Formulation Unit: wt%

[0071]

[0072]

[0073] Table 4 Formulation Unit: wt%

[0074]

[0075] The preparation method of sulfated microcrystalline cellulose used in Comparative Example 6 is based on the journal: Science and Technology Innovation and Application, Issue 22, 2015, by Yu Chengning et al.: Preparation of Nanocellulose by Hydrolysis of Microcrystalline Fibers with Sulfuric Acid and Characterization of Their Properties, Section 1: Experimental Materials and Instruments, Section 2: Preparation of Nanocellulose. The grade of the raw material microcrystalline fiber is CS100S.

[0076] The preparation method of Comparative Example 1 is:

[0077] Deionized water and microcrystalline cellulose were placed in a container, and a homogenizer was turned on at 2000-3000 rpm for 3-5 minutes to homogenize until uniformly mixed, and then stirred at 150-200 rpm for 3-5 minutes. The mixture was allowed to stand to obtain a composition.

[0078] The preparation methods of Comparative Examples 2 to 4 are as follows:

[0079] Deionized water and cationic raw materials are placed in a container, stirred at 150-200 rpm for 5-10 minutes, and allowed to stand to obtain a composition.

[0080] The preparation methods of Comparative Examples 5 to 9 are as follows:

[0081] (1) Place deionized water, microcrystalline cellulose or sodium polystyrene sulfonate in a container, turn on the homogenizer, 2000-3000 rpm, homogenize for 3-5 minutes, mix evenly, and stir at 150-200 rpm for 3-5 minutes;

[0082] (2) Add the cationic raw material to step (1) and stir at 150-200 rpm for 5-10 minutes;

[0083] (4) Allow to stand to obtain a composition.

[0084] The preparation methods of Comparative Examples 10 to 12 are as follows:

[0085] (1) Place deionized water and microcrystalline cellulose in a container, turn on the homogenizer, 2000-3000 rpm, homogenize for 3-5 minutes, mix evenly, and stir at 150-200 rpm for 3-5 minutes;

[0086] (2) Add the cationic raw material to step (1) and stir at 150-200 rpm for 5-10 minutes;

[0087] (3) Add hydrolyzed corn starch to step (2) and stir at 150-200 rpm for 5-10 minutes;

[0088] (4) Allow to stand to obtain a composition.

[0089] Performance Testing

[0090] Test item 1: skin-friendly performance, film-forming performance, and film thickness test;

[0091] 1. Testing scheme for skin-friendly performance and film-forming performance

[0092] By preparing silicon wafers that simulate the skin interface, spin-coating and drying thin film samples, the skin-friendly properties, film-forming properties, and film thickness of the samples were evaluated using optical microscopy and spectroscopic ellipsometer.

[0093] 2. Experimental operation method

[0094] Preparation of simulated skin interface: After mixing concentrated sulfuric acid (H2SO4), hydrogen peroxide (H2O2) and deionized water (H2O) in a ratio of 1:1:1, the original silicon wafer was cleaned and placed on a heating platform at 110℃ for 1 hour. Then it was thoroughly rinsed with deionized water. Due to the presence of a thin layer of natural oxide (SiO x ) layer, this cleaning process produces a very hydrophilic surface. To create a hydrophobic surface, the acid-washed silicon wafer is further immersed in a hydrogen fluoride (HF) aqueous solution for 30 seconds to remove the SiOx layer, that is, a silicon substrate treated with hydrogen fluoride.

[0095] Preparation of thin film samples: The samples obtained in Examples 1-11 and Comparative Examples 1-9 were spin-coated on the silicon substrate, with a spin-coating amount of 100 μL for each sample, and the samples were spin-dried at 25° C.

[0096] 3. Experimental Results

[0097] The film forming properties and skin-friendly properties of the spin-coated and dried thin film samples were observed and photographed using a high-resolution optical microscope (OM) for comparative characterization. The images were taken using reflected light under an Olympus BHT microscope equipped with a differential interference contrast accessory for incident light after Nomarski (NIC model). The OM images were taken with a digital camera at room temperature. The results of Examples 1-11 are shown in Figure 1. Figure 1 As shown, the results of Comparative Examples 1-9 are as follows Figure 2 shown.

[0098] 4. Result analysis:

[0099] 4.1. According to Figure 1 、 Figure 2 It can be found that Examples 1-11 can form uniform and dense films on the simulated skin hydrophobic interface. The results show that Examples 1-11 have excellent skin affinity and can have excellent spreadability and film-forming properties on the interface close to the polarity of the skin, and the film formation is uniform.

[0100] Comparative Examples 1-9 failed to form uniform, dense films on a simulated skin hydrophobic interface, exhibiting localized dewetting. This indicates that the materials lacked good affinity with the interface, agglomerating and exhibiting poor spreadability. These results demonstrate that Examples 1-11 exhibit superior skin affinity, film-forming properties, and spreadability to Comparative Examples 1-9.

[0101] 4.2 The microscopic photograph of Comparative Example 1 shows that the surface of the film formed by using Tempo-treated nanocellulose alone exhibits a relatively obvious dewetting phenomenon. The microscopic photographs of Comparative Examples 2 to 4 also show a relatively obvious dewetting phenomenon, indicating that these cationic raw materials themselves also have a relatively obvious dewetting phenomenon.

[0102] When two hydrophilic products are combined, an unexpected hydrophobic interface affinity effect is exhibited, which is the greatest discovery of the present invention.

[0103] 4.3 From the microscopic photographs of Comparative Examples 5 to 7, it can be seen that when other materials with film-forming function are combined with cationic raw materials, there is a more obvious dewetting phenomenon on the surface, indicating that only the combination of the Tempo-treated nanocellulose of the present invention and the cationic raw materials can improve the hydrophobic affinity with the hydrophobic interface of the skin.

[0104] 4.4 The microscopic photographs of Comparative Examples 8 and 9 demonstrate that the amount of cationic raw material and the amount of tempo-treated nanocellulose used should be flexibly selected based on the type of cationic raw material. Those skilled in the art can determine the appropriate range of amounts for the corresponding cationic raw materials through multiple experiments. Furthermore, Comparative Example 8 demonstrates that using too low a dosage of tempo-treated nanocellulose will not achieve the desired film-forming effect.

[0105] 5. Film thickness test plan

[0106] The thickness of the above-mentioned film samples was measured using a SE-VE ellipsometer (Wuhan Optoelectronic Technology Co., Ltd., China) with an incident angle of 65° and a spectral range of 400-800 nm. The amplitude information (Ψ) and phase information (δ) spectra of the collected wavelength (λ) were simultaneously fitted using Eometrics software (Wuhan Optoelectronic Technology Co., Ltd.), and the Cauchy model was used to determine the thickness and refractive index of the film. To ensure accuracy, at least three readings were taken at different positions for each sample, and the average value was taken. The results of Examples 1-11 and Comparative Examples 1-9 are shown in Table 5.

[0107] Table 5 Statistics of film thickness test results

[0108]

[0109]

[0110] Result analysis: According to Table 5, the lower the average value of the film thickness (nm), the thinner the film formed by the sample and the interface is. The results in Table 2 show that the film thickness of Examples 1-11 is lower than that of Comparative Examples 1-9, and Examples 1-11 can form nano-scale films more excellently.

[0111] By comparing Comparative Example 8 with Example 3, and Comparative Example 9 with Example 1, it can be seen that when the amount of Tempo-treated nanocellulose or carboxymethyl chitosan is lower than the recommended amount, the film thickness increases. However, this does not mean that other cationic raw materials cannot form a film when the amount is lower than this. According to the material properties of different cationic raw materials, different concentrations of the material should be repeatedly verified to obtain the concentration that is suitable for them.

[0112] Test Item 2: High-temperature film-forming performance

[0113] Test plan: Use an electronic balance (precision 0.01 g) to weigh 2.54 g of Example 2, Example 13, Comparative Example 2, Comparative Example 6, Comparative Example 7, and Comparative Example 10 in equal amounts, place them in a polystyrene hydrophobic weighing dish, and then place them in an 80°C electric constant temperature blower drying oven for heating. Take out the samples when they are completely dry, cool them to room temperature, observe their status and take pictures, and evaluate their film-forming performance.

[0114] Experimental results reference Figure 3 ;

[0115] according to Figure 3 It can be seen that the film-forming state of Example 2 and Example 13 is complete, while the film-forming state of Comparative Example 2, Comparative Example 6, Comparative Example 7, and Comparative Example 10 is incomplete, which shows that under high-temperature drying conditions, Example 2 and Example 13 not only have better film-forming performance than Comparative Example 2, Comparative Example 6, Comparative Example 7, and Comparative Example 10, but are also resistant to high temperatures.

[0116] Test Item 3: Instant film-forming feeling, instant firming feeling, and film comfort test

[0117] 3.1 Test Plan

[0118] Five subjects aged 18-45 years were recruited, with no gender restrictions. They used Example 2, Example 5, Example 9, Example 12, Example 13, Example 14, Comparative Example 5, Comparative Example 10, Comparative Example 11, and Comparative Example 12 on their faces once. Each subject tried the above samples, and a questionnaire survey was conducted to obtain the subjects' subjective evaluation results on the instant film-forming feel, instant firming feel, and film comfort of the samples.

[0119] 3.2 Evaluation Criteria

[0120] 1) Instant film-forming effect: 0-5 points (0.5 points is an evaluation gradient, 0 points is no instant film-forming effect, 3.6 points is a sense of instant film-forming effect, 0.5 points is the weakest instant film-forming effect, and 5 points is the strongest instant film-forming effect)

[0121] 2) Instant firming sensation: 0-5 points (0.5 points is a rating gradient, 0 points is no immediate firming sensation, 0.5 points is the weakest immediate film-forming sensation, and 5 points is the strongest immediate firming sensation)

[0122] 3) Comfort of membrane: 0-5 points (0.5 points is a rating gradient, 0 points is the least comfortable, 5 points is the most comfortable)

[0123] (3) Data statistical analysis methods

[0124] Calculate the average score of the corresponding evaluation items after a single use of the sample.

[0125] Test results

[0126] The results are shown in Table 6.

[0127] Table 6 Summary of the average results of the subject evaluation scores

[0128]

[0129]

[0130] According to Table 6, we can get:

[0131] The instant film-forming feeling, instant firming feeling, and film comfort of Example 2, Example 5, Example 9, Example 12, Example 13, and Example 14 are all better than those of Comparative Example 5, Comparative Example 10, Comparative Example 11, and Comparative Example 12, indicating that the embodiments of the present invention have excellent instant film-forming feeling, instant firming feeling, and comfort, and that the hydrolyzed corn starch has a synergistic effect.

[0132] According to the supplier's instructions for hydrolyzed corn starch, it is an excellent film-forming material. The above experiments demonstrate that, when used in the film-forming system of the present invention, hydrolyzed corn starch improves the film's immediate film-forming performance, firmness, and comfort in most cases. This is not the case with other film-forming systems.

[0133] Summarize:

[0134] 1. The present invention uses anionic Tempo nanocellulose and cationic raw materials that can be used in cosmetics to form a uniform, thin film. The film has a strong instant firming film-forming effect, is comfortable to use, has good skin affinity, and has good spreadability.

[0135] 2. The film-forming agent of the present invention has good high temperature resistance. When the film-forming agent acts on hair, the integrity of the film can be maintained when the hair is dried with a hair dryer.

[0136] Part II Cosmetic Sustained Release System

[0137] In this section, the sustained-release properties of the three components, tripeptide-1 copper, ergothioneine, and acetyl hexapeptide-8, were verified by film-forming agents.

[0138] Examples 15 to 17, Comparative Examples 13 to 15

[0139] For specific formula, please refer to Table 7

[0140] Table 7 Formulation Unit: wt%

[0141]

[0142] It should be noted that the present invention uses a 1% concentration of the active ingredient for the purpose of more clearly observing the sustained-release phenomenon. Although this example only verifies a 1% concentration of the active ingredient, it is well known to those skilled in the art that the sustained-release effect does not result from differences in concentration, and any concentration of the active ingredient can be achieved using a sustained-release system.

[0143] The preparation methods of Examples 15 to 17 are as follows:

[0144] (1) Place deionized water and microcrystalline cellulose in a container, turn on the homogenizer, 2000-3000 rpm, homogenize for 3-5 minutes, mix evenly, and stir at 150-200 rpm for 3-5 minutes;

[0145] (2) Add the cationic raw material (hydroxypropyltrimethylammonium chloride hyaluronic acid) to step (1) and stir at 150-200 rpm for 5-10 minutes;

[0146] (3) Add the active ingredients (tripeptide-1 copper, ergothioneine, acetyl hexapeptide-8) to step (2) and stir at 150-200 rpm for 5-10 min;

[0147] (4) Allow to stand to obtain a composition.

[0148] The preparation methods of Comparative Examples 13 to 15 are as follows:

[0149] (1) Deionized water and active ingredients (tripeptide-1 copper, ergothioneine, acetyl hexapeptide-8) were placed in a container, stirred, and mixed evenly at 150-200 rpm for 3-5 min;

[0150] (2) Allow to stand to obtain a composition.

[0151] Sustained release performance test

[0152] 1. Test plan

[0153] The dialysis bag method was used to study the in vitro release behavior of tripeptide-1 copper, ergothioneine, and acetyl hexapeptide-8 in a sustained-release system. Aqueous solution of the same concentration was used as a control and aqueous solution was selected as the release medium.

[0154] 2. Experimental operation method

[0155] First, pretreat the dialysis bag (MW7000), immerse the dialysis bag cut into appropriate lengths in a beaker filled with water, place the beaker in 100°C water and heat continuously for 30 minutes, then take out the beaker and cool it for use. Take 5ml of the active substance-cellulose composition of the same concentration and the corresponding aqueous solution and place them in the dialysis bag. Seal the two ends of the dialysis bag with sealing clips and place it in a wide-mouth bottle to ensure that the dialysis bag is completely immersed in 250ml of the release medium. Stir and dialyze in a 37°C magnetic stirrer. Take out 3ml of the release medium at the preset time points (1, 2, 4, 8, 24h), and add 3ml of fresh sustained-release medium at the same temperature to keep the solution volume in the wide-mouth bottle at 255ml. The peak area of ​​the release medium taken was measured by high-performance liquid chromatography, and the release amount of the drug at different times was calculated according to the standard curve. The cumulative release rate (CR) was calculated by the formula:

[0156]

[0157] 3. Experimental Results

[0158] The results are shown in Tables 8 to 10.

[0159] Table 8 Tripeptide-1 Copper

[0160]

[0161] Table 9 Ergothioneine

[0162]

[0163]

[0164] Table 10 Acetyl Hexapeptide-8

[0165]

[0166] 4. Results Analysis

[0167] The release rates of Example 15, Example 16, and Example 17 are lower than those of Comparative Example 13, Comparative Example 14, and Comparative Example 15, respectively, indicating that the embodiments of the present invention have excellent sustained-release effects.

[0168] The applicant declares that while the above-described embodiments illustrate the process of the present invention, the present invention is not limited to the above-described process steps, nor does it imply that the present invention must rely on the above-described process steps for implementation. Those skilled in the art should understand that any improvements to the present invention, equivalent substitutions for the raw materials used, additions of auxiliary ingredients, and selection of specific methods, etc., fall within the scope of protection and disclosure of the present invention.

Claims

1. A cosmetic sustained-release system, characterized in that: Including film-forming agents and cosmetic active ingredients loaded in the film-forming agents; The film-forming agent comprises the following components in parts by weight: Anionic Tempo nanocellulose 0.002-0.3 parts; 0.0005 to 1 part of cationic raw materials that can be used in cosmetics; The brand of the anionic Tempo nanocellulose is any one of RHEOCRYSTA C-2SP, RHEOCRYSTA I-2SX, RHEOCRYSTA I-2AX, and RHEOCRYSTA I-2SXS.

2. The cosmetic sustained-release system according to claim 1, characterized in that: The cosmetic active ingredients are active ingredients for skin freckle removal and whitening, active ingredients for skin wrinkle resistance, active ingredients for anti-allergy, active ingredients for preventing hair loss, active ingredients for skin acne removal, active ingredients for skin nourishment, active ingredients for skin repair, active ingredients for skin firming, active ingredients for skin soothing, active ingredients for skin oil control, active ingredients for skin exfoliation, active ingredients for preventing hair breakage, active ingredients for body refreshing, active ingredients for scalp dandruff removal, active ingredients for skin moisturizing, and active ingredients for hair care.

3. The cosmetic sustained-release system according to claim 2, characterized in that: The cosmetic active ingredients are one or more combinations of acetyl hexapeptide-8, tripeptide-1 copper, dipotassium glycyrrhizate, panthenol, tranexamic acid, citrus fruit extract, sanguisorba officinalis root extract, withania somnifera root extract, niacinamide, tetrapeptide-1, ergothioneine, arborvitae leaf extract, acetyl tetrapeptide-3, piroctone olamine salt, hexamidine di(hydroxyethylsulfonic acid) salt, hydrolyzed collagen, PCA zinc, and lactobionic acid.

4. The cosmetic sustained-release system according to claim 3, characterized in that: In the cosmetic sustained-release system, the amount of each active ingredient added independently is: Tripeptide-1 copper 0.0001-1 part; Ergothioneine 0.0001-1 part; Acetyl hexapeptide-8 0.000005-0.0025 parts.

5. The cosmetic sustained-release system according to claim 1, characterized in that: The cationic raw material is one or more combinations of carboxymethyl chitosan, sodium DNA, hydroxypropyl trimethyl ammonium chloride hyaluronic acid, basic amino acids, and dipeptide diaminobutyryl benzylamide diacetate; the molecular weight of the carboxymethyl chitosan is 5KDa to 50KDa; the molecular weight of the sodium DNA is 200KDa to 800KDa; the molecular weight of the hydroxypropyl trimethyl ammonium chloride hyaluronic acid is 400KDa to 1000KDa; and the basic amino acid is one or more combinations of lysine, arginine, and histidine.

6. The cosmetic sustained-release system according to claim 5, characterized in that: The molecular weight of the carboxymethyl chitosan is 10KDa to 30KDa; the molecular weight of the sodium DNA is 300KDa to 600KDa; and the molecular weight of the hydroxypropyltrimethylammonium chloride hyaluronic acid is 500KDa to 800KDa.

7. The cosmetic sustained-release system according to claim 4, characterized in that: If the cationic raw material is carboxymethyl chitosan, the amount of the cationic raw material is 0.02 to 0.5 parts; If the cationic raw material is sodium DNA, the amount of the cationic raw material is 0.0005 to 0.05 parts; If the cationic raw material is hydroxypropyltrimonium chloride hyaluronic acid, the amount of the cationic raw material is 0.01 to 1 part; If the cationic raw material is a basic amino acid, the amount of the cationic raw material used is 0.001 to 0.1 parts.

8. The cosmetic sustained-release system according to any one of claims 1 to 5, characterized in that: The film-forming agent further comprises 0.05 to 5 parts of hydrolyzed corn starch.

9. Use of the cosmetic sustained-release system according to any one of claims 1 to 8 in preparing cosmetics.

10. A cosmetic, characterized in that: 0.0025-15 wt% of the cosmetic sustained-release system according to any one of claims 1-8 is added.

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