A kind of heparin sodium with mucosal enzymatic liquid shaking device
By designing a oscillating dispersion and circulating flow mechanism, the problem of uneven mixing between the mucosal enzymatic hydrolysate and the heparin sodium solution was solved, achieving a highly efficient heparin sodium extraction effect.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- YANGZHOU XINGRUI BIOTECHNOLOGY CO LTD
- Filing Date
- 2025-06-30
- Publication Date
- 2026-07-07
AI Technical Summary
Traditional mixing methods make it difficult to achieve a thorough and uniform mixing of the mucosal enzymatic hydrolysate and the heparin sodium solution, resulting in low extraction efficiency and unstable product quality.
A shaking device for heparin sodium mucosal enzymatic hydrolysate was designed, comprising a shaking and dispersing mechanism, a conveying mechanism, a power mechanism, and a circulation mechanism, which promotes uniform mixing of enzymatic hydrolysate and heparin sodium solution through shaking and circulation.
This method achieves thorough mixing of the mucosal enzymatic hydrolysate and the heparin sodium solution, improving extraction efficiency and product quality, and avoiding quality problems caused by uneven mixing.
Smart Images
Figure CN120605642B_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of heparin sodium extraction technology, and in particular to a shaking device for heparin sodium using mucosal enzymatic hydrolysis solution. Background Technology
[0002] Heparin sodium is an important anticoagulant with wide applications in clinical medicine, such as the prevention and treatment of thrombotic diseases. Heparin sodium is typically extracted from animal intestinal mucosa and other tissues, and the mucosal enzymatic hydrolysate plays a crucial role in the extraction process. The mucosal enzymatic hydrolysate contains various enzymes that act on animal mucosal tissues, breaking down proteins and other components bound to heparin sodium, thereby releasing the sodium.
[0003] In the extraction process of heparin sodium, thorough mixing of the mucosal enzymatic hydrolysate with the heparin sodium-containing solution is a crucial step. Only when the two are thoroughly mixed can the enzymes in the hydrolysate make full contact with the mucosal tissue and exert their effects, thereby improving the extraction efficiency and quality of heparin sodium.
[0004] However, in actual production, due to the high viscosity of the mucosal enzymatic hydrolysate and the heparin sodium solution, traditional mixing methods often fail to achieve thorough and uniform mixing. For example, simple stirring may not reach every corner of the solution, resulting in insufficient mixing in some areas, which in turn affects the extraction efficiency of heparin sodium.
[0005] In addition, uneven mixing during the mixing process may lead to incomplete reaction and low extraction efficiency, which not only increases production costs but may also affect the quality and stability of the final product.
[0006] To address the aforementioned problems, this invention proposes a shaking device for heparin sodium with mucosal enzymatic hydrolysate. Summary of the Invention
[0007] To address the shortcomings of existing technologies, this invention provides a shaking device for heparin sodium mucosal enzymatic hydrolysate. This solves the problem that the simple stirring method in existing technologies may not be able to reach all corners of the solution, resulting in insufficient mixing in some areas, which in turn affects the extraction effect of heparin sodium. At the same time, uneven mixing during the mixing process may also lead to incomplete reaction and low extraction efficiency.
[0008] The objective of this invention is achieved as follows: A shaking device for heparin sodium with mucosal enzymatic hydrolysate, comprising:
[0009] The chassis has a partition fixedly installed inside it;
[0010] An oscillation dispersion mechanism is disposed on the top of the partition plate, connected to the inner wall of the chassis, and extends to the outer side of the chassis on one side and connects to one side of the chassis;
[0011] Multiple conveying mechanisms are installed at equal intervals inside the chassis. The same conveying bend is connected to the multiple conveying mechanisms. One end of the conveying bend is fixedly connected to the inner wall of one side of the chassis, and the other end passes through the partition and extends to the top of the partition. A tapered tube is fixedly installed at the top end. The tapered tube is fixedly connected to the partition and is used to convey the mixture of enzymatic hydrolysate and heparin sodium solution to the top of the partition to achieve oscillation mixing of the mixture.
[0012] A power mechanism is installed inside the housing and is connected to multiple conveying mechanisms to provide power to the conveying mechanisms and drive the multiple conveying mechanisms to move.
[0013] A circulating flow mechanism is installed at the bottom of one side of the chassis, extending into the chassis on both sides and located above and below the partition plate respectively. One side is connected to multiple conveying mechanisms. During the shaking of the mixture, the mixture is kept circulating to promote thorough mixing of the enzymatic hydrolysate and heparin sodium solution.
[0014] In one possible design, the oscillation dispersion mechanism includes multiple dispersion mesh plates fixedly mounted at equal intervals on the top of the partition plate, with both sides of the dispersion mesh plates fixedly connected to the inner walls of both sides of the chassis; multiple oscillation plates are slidably mounted on the multiple dispersion mesh plates, and the multiple oscillation plates are arranged at equal intervals inside the chassis and connected to the same power component, with one side of the power component extending to the outside of the chassis and connecting to one side of the chassis.
[0015] In one possible design, the power assembly includes a drive motor fixedly mounted on the top side of the chassis, a crank fixedly mounted on the output shaft of the drive motor, one end of the crank being rotatably connected to the top side of the chassis; it also includes a plurality of transmission rods, each of which passes through a plurality of the vibrating plates and is fixedly connected to the plurality of the vibrating plates, one end of each of the plurality of transmission rods extending to the outside of the chassis, and the transmission rods being slidably and sealingly connected to the inner wall of the chassis;
[0016] The crank has multiple bends at equal intervals. One end of the transmission rod is fixedly fitted with a transmission ring. The crank passes through multiple transmission rings respectively. A sliding plate is rotatably sleeved on the bend and the sliding plate is slidably connected to the corresponding transmission ring.
[0017] In one possible design, the conveying mechanism includes a mounting frame fixedly mounted inside the chassis, a conveying box fixedly mounted through the mounting frame, an installation pipe fixedly mounted through the top inner wall of the conveying box, the top end of the installation pipe extending into the conveying bend and fixedly connected to the bottom inner wall of the conveying bend, and a connecting pipe fixedly mounted on the bottom inner wall of the conveying box, the bottom end of the connecting pipe extending below the conveying box and connected to the circulating flow mechanism.
[0018] The conveyor box is equipped with a first one-way component and a second one-way component located below the first one-way component. The bottom of the second one-way component extends into the chassis and is connected to the power mechanism.
[0019] Driven by the power mechanism, the second one-way component reciprocates longitudinally along the inner wall of the conveying box. Under the transmission of the first one-way component, it conveys the mixture in the circulating flow mechanism to the conveying box through the connecting pipe, and then conveys it to the conveying bend through the first one-way component, the second one-way component and the mounting pipe, so as to realize the stable upward conveying of the mixture.
[0020] In one possible design, the first unidirectional component includes a fixed frame fixedly mounted inside the conveyor box, a first support frame fixedly mounted at the bottom of the fixed frame, a first movable rod slidably mounted through the first support frame, a first sealing plate fixedly mounted at the top of the first movable rod, the first sealing plate penetrating the fixed frame and tightly fitting against the inner wall of the fixed frame; a first compression spring is sleeved on the first movable rod located below the first support frame, the top and bottom ends of the first compression spring being fixedly connected to the bottom of the first support frame and the bottom end of the first movable rod respectively by hooks.
[0021] In one possible design, the second unidirectional component includes a movable frame tightly slidably fitted within the conveyor box. A second support frame is fixedly fitted to the bottom of the movable frame. A second movable rod is slidably fitted through the second support frame. A second sealing plate is fixedly fitted to the top of the second movable rod, penetrating the movable frame and tightly fitting against the inner wall of the movable frame. A second compression spring is sleeved on the second movable rod, located below the second support frame. The top and bottom ends of the second compression spring are respectively fixedly connected to the bottom of the second support frame and the bottom end of the second movable rod via hooks. A driving member is provided at the bottom of the movable frame, penetrating the inner wall of the bottom of the conveyor box and extending downwards, with its bottom connected to the power mechanism.
[0022] In one possible design, the driving component includes two piston rods symmetrically fixedly mounted at the bottom of the movable frame, and two power pipes symmetrically fixedly mounted at the bottom of the conveying box. The bottom ends of the piston rods penetrate the inner wall of the bottom of the conveying box and extend into the corresponding power pipes, and are tightly slidably connected to the inner wall of the power pipes. The bottom ends of the two power pipes are fixedly mounted with the same dispersion pipe, one end of which is fixedly connected to a flow pipe, and one end of the flow pipe is connected to the power mechanism.
[0023] The power mechanism distributes hydraulic oil through the flow pipe and the dispersion pipe into the two power pipes, pushing the piston rod to move longitudinally, thereby driving the moving frame to move longitudinally within the conveying box, providing driving force for the delivery of the mixture.
[0024] In one possible design, the power mechanism includes a power box fixedly mounted inside the chassis. A liquid injection pipe is fixedly mounted on the inner wall of one bottom side of the power box, with one end extending to the outside of the chassis. A sealing plug is fixedly mounted inside the liquid injection pipe. Two electric actuators are fixedly mounted on the other side of the chassis. The output shafts of both electric actuators extend into the power box and are fixedly mounted with the same piston plate. The piston plate is slidably connected to the inner wall of the power box. A flow divider is fixedly mounted through one inner wall of the power box. One end of a plurality of flow tubes extends into the flow divider and is fixedly connected to the inner wall of the flow divider. Hydraulic oil is contained in the area between the piston plate and the flow divider inside the power box.
[0025] In one possible design, the circulating flow mechanism includes a mixing pipe fixedly mounted on the bottom of one side of the housing, an injection pipe fixedly mounted through the inner wall of one side of the mixing pipe, and a sealing plug fixedly mounted inside the injection pipe; a mixing screw for mixing the liquid is provided inside the mixing pipe, one end of which is connected to a conveying assembly, one side of which extends into the housing and is connected to the top inner wall of one side of the housing; a second discharge pipe is fixedly mounted on the other end of the mixing pipe, one end of which extends into the housing and is fixedly mounted with a support pipe, the support pipe being fixedly connected to a plurality of the connecting pipes respectively.
[0026] In one possible design, the conveying assembly includes a connecting cylinder fixedly mounted on the outside of the chassis. Multiple liquid outlet pipes are fixedly mounted at equal intervals on the inner wall of the top of the connecting cylinder. The top ends of the liquid outlet pipes extend into the chassis and are fixedly connected to the inner wall of the chassis. A first discharge pipe is fixedly mounted on the inner wall of the bottom of the connecting cylinder. The bottom end of the first discharge pipe extends to one side of the chassis and is fixedly connected to one end of the mixing pipe.
[0027] It should be understood that the above general description and the following detailed description are merely exemplary and do not limit the invention.
[0028] Compared with the prior art, the beneficial effects of the present invention are as follows: In the present invention, through the set oscillating dispersion mechanism, after the mixture of enzymatic hydrolysate and heparin sodium solution is conveyed to the top of the partition through the conveying bend, it can flow along the partition. After the mixture of enzymatic hydrolysate and heparin sodium solution passes through multiple dispersion mesh plates, it can promote the fusion of the mixture of enzymatic hydrolysate and heparin sodium solution. At the same time, the power component can be activated to drive multiple oscillating plates to reciprocate laterally along multiple dispersion mesh plates, so that after the mixture of enzymatic hydrolysate and heparin sodium solution flows into the area between multiple dispersion mesh plates, it can be vibrated by the vibration force of the oscillating plates, which can effectively promote the uniform mixing of the mixture of enzymatic hydrolysate and heparin sodium solution.
[0029] In this invention, the conveying mechanism allows the second unidirectional component to reciprocate longitudinally along the inner wall of the conveying box after being driven by the power mechanism. This, in conjunction with the first unidirectional component, enables the mixture of enzymatic hydrolysate and heparin sodium solution in the circulating flow mechanism to be conveyed through the connecting pipe into the conveying box. The mixture is then conveyed through the first and second unidirectional components and the mounting pipe into the conveying bend, thus facilitating the conveying of the mixture of enzymatic hydrolysate and heparin sodium solution to the top of the partition via the conveying bend, achieving a stable flow of the mixture.
[0030] In this invention, the power mechanism can drive the piston plate to reciprocate laterally in the power box by activating two electric push rods. When the piston plate approaches the distribution pipe, it can push hydraulic oil into the distribution pipe, and then distribute it to multiple flow pipes. This allows hydraulic oil to be injected into multiple power pipes to push the piston rod upward. When the piston plate moves in the opposite direction, it can generate suction to draw the hydraulic oil into the power box. At this time, the hydraulic oil in the power pipe can flow back, causing the piston rod to move downward. Therefore, when the piston plate reciprocates laterally, it can continuously drive the moving frame to reciprocate longitudinally, thereby driving the mixture of enzymatic hydrolysate and heparin sodium solution to flow.
[0031] In this invention, a circulating flow mechanism is used to inject the mixture of driving enzyme hydrolysate and heparin sodium solution into the mixing tube through the injection pipe. The mixture flows along the mixing screw, and the mixing screw creates a blocking effect as the mixture flows, causing collisions between the two solutions. This effectively promotes uniform mixing. Subsequently, multiple conveying mechanisms transport the mixture to a partition, and after mixing by a oscillating dispersion mechanism, the mixture is returned to the mixing tube via a conveying assembly. This circulation ensures thorough mixing of the driving enzyme hydrolysate and heparin sodium solution.
[0032] In the process of mixing the mucosal enzymatic hydrolysate with the solution containing heparin sodium, this invention maintains the circulation and agitation of both solutions, effectively promoting uniform mixing and ensuring the optimal effect of the heparin sodium solution. Attached Figure Description
[0033] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on the provided drawings without creative effort.
[0034] Figure 1 This is a three-dimensional schematic diagram of the first-view structure of the present invention.
[0035] Figure 2 This is a three-dimensional schematic diagram of the second-view structure of the present invention.
[0036] Figure 3 This is a schematic diagram of the main cross-sectional structure of the present invention.
[0037] Figure 4 This is a three-dimensional schematic diagram of the connection structure of the chassis, partition, multiple dispersing mesh plates and multiple oscillating plates of the present invention.
[0038] Figure 5 This is a three-dimensional schematic diagram of the connection structure of the drive motor, crank, multiple transmission rods and multiple vibration plates of the present invention.
[0039] Figure 6This is a first-view three-dimensional schematic diagram of the connection structure of the conveying bend, mixing pipe, first flow pipe, second flow pipe and support pipe of the present invention.
[0040] Figure 7 This is a second-view three-dimensional schematic diagram of the connection structure of the conveying bend, mixing pipe, first flow pipe, second flow pipe and support pipe of the present invention.
[0041] Figure 8 This is a three-dimensional schematic diagram from a third perspective of the connection structure of the conveying bend, mixing pipe, first flow pipe, second flow pipe and support pipe of the present invention.
[0042] Figure 9 This is a side sectional view of the conveyor box of the present invention.
[0043] Figure 10 This is a three-dimensional cross-sectional schematic diagram of the conveyor box structure of the present invention.
[0044] Figure 11 This is a three-dimensional cross-sectional view of the power box structure of the present invention.
[0045] Figure 12 This is a three-dimensional cross-sectional schematic diagram of the hybrid tube structure of the present invention.
[0046] Among them, 1. Chassis; 2. Partition plate; 3. Dispersing mesh plate; 4. Vibrating plate; 5. Transmission rod; 6. Transmission ring; 7. Drive motor; 8. Curved rod; 9. Slide plate; 10. Conveying bend; 11. Tapered tube; 12. Mounting frame; 13. Conveying box; 14. Fixing frame; 15. First support frame; 16. First moving rod; 17. First sealing plate; 18. First compression spring; 19. Mounting tube; 20. Moving frame; 21. Second support frame; 22. ... 23. Second moving rod; 24. Second sealing plate; 25. Second compression spring; 26. Piston rod; 27. Power pipe; 28. Dispersion pipe; 29. Flow pipe; 30. Diverter pipe; 31. Power box; 32. Injection pipe; 33. Electric push rod; 34. Piston plate; 35. Mixing pipe; 36. Injection pipe; 37. First discharge pipe; 38. Connecting cylinder; 39. Discharge pipe; 40. Second discharge pipe; 41. Support pipe; 42. Connecting pipe; 43. Mixing screw. Detailed Implementation
[0047] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.
[0048] Example 1: Refer to Figure 1-12A oscillation device includes a housing 1, with a partition 2 fixedly installed inside the housing 1. A oscillation dispersion mechanism is located at the top of the partition 2, connected to the inner wall of the housing 1, extending to the outside of the housing 1 and connecting to one side of the housing 1. Multiple conveying mechanisms are installed at equal intervals inside the housing 1, and these conveying mechanisms are connected to the same conveying bend 10. One end of the conveying bend 10 is fixedly connected to the inner wall of one side of the housing 1, and the other end passes through the partition 2 and extends above the partition 2. A tapered tube 11 is fixedly installed at its top end, and the tapered tube 11 is fixedly connected to the partition 2, used to convey a mixture of enzymatic hydrolysate and heparin sodium solution to the area above the partition 2 for oscillation mixing. A power mechanism is also installed inside the housing 1, connected to the multiple conveying mechanisms to provide power to them. A circulating flow mechanism is installed at the bottom of one side of the housing 1, extending into the housing 1 on both sides and located above and below the partition 2 respectively. One side is connected to the multiple conveying mechanisms, allowing the mixture to circulate during oscillation, promoting thorough mixing.
[0049] The oscillation dispersion mechanism consists of multiple dispersion mesh plates 3 fixedly installed at equal intervals on the top of the partition plate 2. The two sides of each dispersion mesh plate 3 are fixedly connected to the inner walls of both sides of the housing 1. Multiple oscillation plates 4 are slidably connected to the multiple dispersion mesh plates 3. The oscillation plates 4 are arranged at equal intervals inside the housing 1 and connected to the same power component. The power component includes a drive motor 7 fixedly installed on the top of one side of the housing 1. A crank rod 8 is fixedly installed on the output shaft of the drive motor 7, and one end of the crank rod 8 is rotatably connected to the top of one side of the housing 1. Multiple transmission rods 5 are also provided, each passing through and fixedly connected to one of the multiple oscillation plates 4. One end of each transmission rod 5 extends to the outside of the housing 1, and the transmission rod 5 is slidably and sealed to the inner wall of the housing 1. Multiple curved sections are provided at equal intervals on the crank rod 8. A transmission ring 6 is fixedly installed on one end of each transmission rod 5, and the crank rod 8 passes through multiple transmission rings 6. A sliding plate 9 is rotatably fitted onto each curved section, and the sliding plate 9 is slidably connected within the corresponding transmission ring 6. After the mixture is conveyed to the top of the partition plate 2 through the conveying bend 10, it flows along the partition plate 2 and is initially mixed by multiple dispersing mesh plates 3. The drive motor 7 is started, which drives the crank 8 to rotate. The curved part of the crank 8 moves in a ring. Under the sliding cooperation of the slide plate 9 and the transmission ring 6, the drive transmission ring 6 drives the transmission rod 5 to move laterally back and forth, so that multiple vibrating plates 4 vibrate laterally back and forth along multiple dispersing mesh plates 3, which promotes uniform mixing of the mixture.
[0050] The conveying mechanism includes a mounting bracket 12 fixedly installed inside the housing 1, through which a conveyor box 13 is fixedly installed. A mounting pipe 19 is fixedly installed through the top inner wall of the conveyor box 13, with its top end extending into a conveying bend 10 and fixedly connected to the bottom inner wall of the conveying bend 10. A connecting pipe 41 is fixedly installed on the bottom inner wall of the conveyor box 13, with its bottom end extending below the conveyor box 13 and connected to a circulating flow mechanism. A first unidirectional component and a second unidirectional component located below it are installed inside the conveyor box 13. The bottom of the second unidirectional component extends into the housing 1 and is connected to a power mechanism.
[0051] The first one-way component consists of a fixed frame 14 and a first support frame 15 at the bottom of the fixed frame 14, both fixedly installed within the conveying box 13. A first moving rod 16 is slidably connected through the first support frame 15. A first sealing plate 17 is fixedly installed at the top of the first moving rod 16, passing through the fixed frame 14 and tightly fitting against the inner wall of the fixed frame 14. A first compression spring 18 is sleeved on the first moving rod 16, located below the first support frame 15. The top and bottom ends of the first compression spring 18 are fixedly connected to the bottom of the first support frame 15 and the bottom end of the first moving rod 16, respectively, via hooks. Under normal conditions, the first compression spring 18 pushes the first moving rod 16 downward, causing the first sealing plate 17 to fit tightly against the fixed frame 14. When the second one-way component moves downward, a negative pressure is created between the second one-way component and the fixed frame 14, causing the second one-way component to open and close, drawing in the mixture. When the second one-way component moves upward, it pushes the mixture upward, causing the first sealing plate 17 to move upward. The mixture flows upward through the fixed frame 14 and is conveyed through the installation pipe 19 to the conveying bend 10.
[0052] The second unidirectional component includes a movable frame 20 tightly slidably connected within the conveyor box 13. A second support frame 21 is fixedly mounted at the bottom of the movable frame 20. A second movable rod 22 is slidably connected through the second support frame 21. A second sealing plate 23 is fixedly mounted at the top of the second movable rod 22, penetrating the movable frame 20 and tightly fitting against the inner wall of the movable frame 20. A second compression spring 24 is sleeved on the second movable rod 22, located below the second support frame 21. The top and bottom ends of the second compression spring 24 are fixedly connected to the bottom of the second support frame 21 and the bottom end of the second movable rod 22 respectively via hooks. A driving component is provided at the bottom of the movable frame 20. The driving component includes two piston rods 25 symmetrically fixedly mounted at the bottom of the movable frame 20. Two power pipes 26 are symmetrically fixedly mounted at the bottom of the conveyor box 13. The bottom ends of the piston rods 25 penetrate the inner wall of the bottom of the conveyor box 13 and extend into the corresponding power pipes 26, where they are tightly slidably connected to the inner wall of the power pipes 26. Two power pipes 26 are fixedly installed at their bottom ends with the same dispersion pipe 27. One end of the dispersion pipe 27 is fixedly connected to the flow pipe 28, and the other end of the flow pipe 28 is connected to the power mechanism. The driving component receives the driving force of the power mechanism, which drives the moving frame 20 to move longitudinally back and forth in the conveying box 13. When the moving frame 20 moves downward, the second sealing plate 23 moves upward under negative pressure, and the mixture flows in. When the moving frame 20 moves upward, it pushes the mixture to move the first sealing plate 17 upward, and the mixture flows into the conveying bend 10, realizing the circulation conveying.
[0053] The power mechanism includes a power box 30 fixedly installed inside the housing 1. A liquid injection pipe 31 is fixedly installed on the inner wall of the bottom side of one side of the power box 30. One end of the liquid injection pipe 31 extends to the outside of the housing 1, and a sealing plug is fixedly installed inside the liquid injection pipe 31. Two electric actuators 32 are fixedly installed on the other side of the housing 1. The output shafts of the two electric actuators 32 extend into the power box 30 and are fixedly installed on the same piston plate 33. The piston plate 33 is slidably connected to the inner wall of the power box 30. A flow divider pipe 29 is fixedly installed through the inner wall of one side of the power box 30. One end of multiple flow pipes 28 extends into the flow divider pipe 29 and is fixedly connected to the inner wall of the flow divider pipe 29. Hydraulic oil is contained in the area between the piston plate 33 and the flow divider pipe 29 inside the power box 30. Two electric push rods 32 are activated to drive the piston plate 33 to reciprocate laterally within the power box 30. When the piston plate 33 approaches the distribution pipe 29, it pushes the hydraulic oil into the distribution pipe 29, which then distributes it to multiple flow pipes 28. Hydraulic oil is injected into multiple power pipes 26, pushing the piston rod 25 upward. When the piston plate 33 moves in the opposite direction, it creates suction, causing the hydraulic oil to flow back and the piston rod 25 to move downward, driving the moving frame 20 to reciprocate longitudinally and causing the mixture to flow.
[0054] This application can be used in the field of heparin sodium extraction technology, or in other fields applicable to this application.
[0055] Example 2: Reference Figure 1 , Figure 6 , Figure 7 , Figure 8 and Figure 11An improvement upon Example 1: A shaking device for heparin sodium mucosal enzymatic hydrolysate, applied to the field of heparin sodium extraction technology, includes a circulating flow mechanism comprising a mixing tube 34 fixedly installed at the bottom of one side of a housing 1, with a feeding tube 35 fixedly installed through the inner wall of one side of the mixing tube 34, and a sealing plug fixedly installed inside the feeding tube 35. A mixing screw 42 is provided inside the mixing tube 34 for mixing the liquid, and one end is connected to a conveying assembly. The conveying assembly includes a connecting cylinder 37 fixedly installed on the outside of the housing 1, with multiple outlet pipes 38 fixedly installed at equal intervals on the inner wall of the top of the connecting cylinder 37, the top ends of the outlet pipes 38 extending into the housing 1 and fixedly connected to the inner wall of the housing 1, and a first discharge pipe 36 fixedly installed on the inner wall of the bottom of the connecting cylinder 37, the bottom end of the first discharge pipe 36 extending to one side of the housing 1 and fixedly connected to one end of the mixing tube 34. A second discharge pipe 39 is fixedly installed at the other end of the mixing tube 34, one end of the second discharge pipe 39 extending into the housing 1 and fixedly installed with a support pipe 40, which is fixedly connected to multiple connecting pipes 41. The mixture is injected into the mixing pipe 34 through the injection pipe 35 and flows along the mixing screw 42. The mixing screw 42 obstructs the mixture, causing it to collide and achieve initial mixing. When multiple conveying mechanisms move, the mixture is conveyed to the top of the partition plate 2. After being mixed by the vibration dispersion mechanism, it is conveyed to the connecting cylinder 37 through multiple liquid outlet pipes 38, and then flows back into the mixing pipe 34 through the first discharge pipe 36, achieving circulation and thorough mixing.
[0056] Working principle: First, inject an appropriate amount of hydraulic oil into the power box 30 through the injection pipe 31, and seal the injection pipe 31 with a sealing plug to prevent hydraulic oil leakage. Connect the electric push rod 32 to the power supply so that it can work normally. Prepare the enzyme hydrolysate and heparin sodium solution to be mixed, and inject them into the mixing pipe 34 through the injection pipe 35. Seal the injection pipe 35 with a sealing plug. Then, start the two electric push rods 32 to drive the piston plate 33 to move laterally and reciprocally in the power box 30. When the piston plate 33 approaches the distribution pipe 29, it pushes the hydraulic oil into the distribution pipe 29, and then distributes it to multiple flow pipes 28 through the distribution pipe 29. In turn, it injects hydraulic oil into multiple power pipes 26, pushing the piston rod 25 to move upward.When the piston plate 33 moves in the reverse direction, it creates suction, drawing hydraulic oil into the power box 30. At this time, the hydraulic oil entering the power pipe 26 flows back, causing the piston rod 25 to move downward. Through the lateral reciprocating motion of the piston plate 33, the moving frame 20 is continuously driven to perform longitudinal reciprocating motion. When the moving frame 20 moves downward, the second sealing plate 23 moves upward under the negative pressure in the area between the moving frame 20 and the fixed frame 14, keeping the moving frame 20 in a connected state. Under the negative pressure, the mixture of enzymatic hydrolysate and heparin sodium solution flows through the connecting pipe 41 and the moving frame 20 into the area between the moving frame 20 and the fixed frame 14. Within the region, when the movable frame 20 moves upward, it creates a thrust on the mixture of enzymatic hydrolysate and heparin sodium solution located in the area between the movable frame 20 and the fixed frame 14. At this time, the first sealing plate 17 moves upward under the action of hydraulic pressure, causing the mixture of enzymatic hydrolysate and heparin sodium solution to flow through the fixed frame 14 and the mounting pipe 19 into the conveying bend 10. This cycle continues, conveying the mixture of enzymatic hydrolysate and heparin sodium solution through the conveying box 13, the mounting pipe 19, and the conveying bend 10 to the area above the partition 2. After being conveyed to the area above the partition 2 through the conveying bend 10, the mixture of enzymatic hydrolysate and heparin sodium solution will flow along the partition. 2. The solution flows through multiple dispersing mesh plates 3, achieving initial fusion. The drive motor 7 is activated, causing the crank 8 to rotate. Multiple curved sections on the crank 8 undergo circular motion. With the sliding engagement of the slide plate 9 and the corresponding transmission ring 6, the drive ring 6 drives the transmission rod 5 to reciprocate laterally. This drives multiple vibrating plates 4 to reciprocate laterally along the length of the dispersing mesh plates 3. Therefore, after the mixture of enzymatic hydrolysate and heparin sodium solution flows into the area between the multiple dispersing mesh plates 3, it is vibrated by the vibration force of the vibrating plates 4, effectively promoting the uniform mixing of the enzymatic hydrolysate and heparin sodium solution. The mixture of enzymatic hydrolysate and heparin sodium solution, after being agitated and mixed, is conveyed through multiple outlet pipes 38 to the connecting cylinder 37, and then returned to the mixing pipe 34 through the first discharge pipe 36. In the mixing pipe 34, the mixing screw 42 performs a secondary mixing of the enzymatic hydrolysate and heparin sodium solution. The mixing screw 42 creates a blocking effect as the mixture flows, causing collisions and further promoting uniform mixing of the enzymatic hydrolysate and heparin sodium solution. Therefore, the mixed solution is again conveyed by the conveying mechanism to the area above the partition 2 for agitation and mixing. This cycle is repeated to ensure thorough mixing of the enzymatic hydrolysate and heparin sodium solution.
[0057] However, as is well known to those skilled in the art, the working principle and wiring method of the drive motor 7 and the electric push rod 32 are commonplace and are all conventional means or common knowledge. They will not be described in detail here. Those skilled in the art can make any selections according to their needs or convenience.
[0058] The above description of the embodiments is only for the purpose of helping to understand the method and core ideas of the present invention. It should be noted that those skilled in the art can make several improvements and modifications to the present invention without departing from the principles of the present invention, and these improvements and modifications also fall within the protection scope of the claims of the present invention.
Claims
1. A shaking device for heparin sodium with mucosal enzymatic hydrolysate, characterized in that, include: The chassis has a partition fixedly installed inside it; An oscillation dispersion mechanism is disposed on the top of the partition plate, connected to the inner wall of the chassis, and extends to the outer side of the chassis on one side and connects to one side of the chassis; Multiple conveying mechanisms are installed at equal intervals inside the chassis. The same conveying bend is connected to the multiple conveying mechanisms. One end of the conveying bend is fixedly connected to the inner wall of one side of the chassis, and the other end passes through the partition and extends to the top of the partition. A tapered tube is fixedly installed at the top end. The tapered tube is fixedly connected to the partition and is used to convey the mixture of enzymatic hydrolysate and heparin sodium solution to the top of the partition to achieve oscillation mixing of the mixture. A power mechanism is installed inside the housing and is connected to multiple conveying mechanisms to provide power to the conveying mechanisms and drive the multiple conveying mechanisms to move. A circulating flow mechanism is installed at the bottom of one side of the chassis, and extends into the chassis on both sides and is located above and below the partition plate respectively. One side is connected to multiple conveying mechanisms. During the shaking of the mixture, the mixture is kept circulating to promote the full mixing of the enzymatic hydrolysate and the heparin sodium solution. The oscillation dispersion mechanism includes multiple dispersion mesh plates fixedly mounted at equal intervals on the top of the partition plate, and the two sides of the dispersion mesh plates are respectively fixedly connected to the inner walls of the two sides of the chassis; multiple oscillation plates are slidably mounted on the multiple dispersion mesh plates, the multiple oscillation plates are arranged at equal intervals inside the chassis and connected to the same power component, one side of the power component extends to the outside of the chassis and connects to one side of the chassis; The conveying mechanism includes a mounting frame fixedly assembled inside the chassis, a conveying box fixedly assembled through the mounting frame, an installation pipe fixedly assembled through the top inner wall of the conveying box, the top end of the installation pipe extending into the conveying bend and fixedly connected to the bottom inner wall of the conveying bend, and a connecting pipe fixedly assembled on the bottom inner wall of the conveying box, the bottom end of the connecting pipe extending below the conveying box and connected to the circulating flow mechanism. The conveyor box is equipped with a first one-way component and a second one-way component located below the first one-way component. The bottom of the second one-way component extends into the chassis and is connected to the power mechanism. Driven by the power mechanism, the second one-way component reciprocates longitudinally along the inner wall of the conveying box. Under the transmission of the first one-way component, it conveys the mixture in the circulating flow mechanism to the conveying box through the connecting pipe, and then conveys it to the conveying bend through the first one-way component, the second one-way component and the mounting pipe, so as to realize the stable upward conveying of the mixture.
2. The heparin sodium enzymatic hydrolysate shaking device according to claim 1, characterized in that, The power assembly includes a drive motor fixedly mounted on the top side of the chassis, a crank fixedly mounted on the output shaft of the drive motor, one end of the crank being rotatably connected to the top side of the chassis; it also includes multiple transmission rods, each of which passes through multiple vibrating plates and is fixedly connected to the multiple vibrating plates, one end of each of the multiple transmission rods extending to the outside of the chassis, and the transmission rods being slidably and sealingly connected to the inner wall of the chassis; The crank has multiple bends at equal intervals. One end of the transmission rod is fixedly fitted with a transmission ring. The crank passes through multiple transmission rings respectively. A sliding plate is rotatably sleeved on the bend and the sliding plate is slidably connected to the corresponding transmission ring.
3. The heparin sodium enzymatic hydrolysate shaking device according to claim 1, characterized in that, The first unidirectional component includes a fixed frame fixedly mounted inside the conveyor box, a first support frame fixedly mounted at the bottom of the fixed frame, a first moving rod slidably mounted through the first support frame, a first sealing plate fixedly mounted at the top of the first moving rod, the first sealing plate penetrating the fixed frame and tightly fitting against the inner wall of the fixed frame; a first compression spring is sleeved on the first moving rod located below the first support frame, the top and bottom ends of the first compression spring being fixedly connected to the bottom of the first support frame and the bottom end of the first moving rod respectively by hooks.
4. The heparin sodium enzymatic hydrolysate shaking device according to claim 1, characterized in that, The second unidirectional component includes a movable frame tightly slidably assembled within the conveyor box. A second support frame is fixedly assembled at the bottom of the movable frame. A second movable rod is slidably assembled through the second support frame. A second sealing plate is fixedly assembled at the top of the second movable rod. The second sealing plate passes through the movable frame and is tightly fitted against the inner wall of the movable frame. A second compression spring is sleeved on the second movable rod, located below the second support frame. The top and bottom ends of the second compression spring are fixedly connected to the bottom of the second support frame and the bottom end of the second movable rod, respectively, via hooks. A driving component is provided at the bottom of the movable frame. The driving component passes through the inner wall of the bottom of the conveyor box and extends downwards, with its bottom connected to the power mechanism.
5. The heparin sodium mucosal enzymatic hydrolysate shaking device according to claim 4, characterized in that, The driving component includes two piston rods symmetrically fixedly mounted at the bottom of the movable frame, and two power pipes symmetrically fixedly mounted at the bottom of the conveying box. The bottom end of the piston rod penetrates the inner wall of the bottom of the conveying box and extends into the corresponding power pipe, and is tightly slidably connected to the inner wall of the power pipe. The bottom ends of the two power pipes are fixedly mounted with the same dispersion pipe, one end of the dispersion pipe is fixedly connected to a flow pipe, and one end of the flow pipe is connected to the power mechanism. The power mechanism distributes hydraulic oil through the flow pipe and the dispersion pipe into the two power pipes, pushing the piston rod to move longitudinally, thereby driving the moving frame to move longitudinally within the conveying box, providing driving force for the delivery of the mixture.
6. The heparin sodium mucosal enzymatic hydrolysate shaking device according to claim 5, characterized in that, The power mechanism includes a power box fixedly mounted inside the chassis. A liquid injection pipe is fixedly mounted on the inner wall of one bottom side of the power box, with one end extending to the outside of the chassis. A sealing plug is fixedly mounted inside the liquid injection pipe. Two electric push rods are fixedly mounted on the other side of the chassis. The output shafts of both electric push rods extend into the power box and are fixedly mounted with the same piston plate. The piston plate is slidably connected to the inner wall of the power box. A flow divider is fixedly mounted through one inner wall of the power box. One end of multiple flow tubes extends into the flow divider and is fixedly connected to the inner wall of the flow divider. Hydraulic oil is contained in the area between the piston plate and the flow divider inside the power box.
7. The heparin sodium mucosal enzymatic hydrolysate shaking device according to claim 1, characterized in that, The circulating flow mechanism includes a mixing pipe fixedly mounted on the bottom of one side of the chassis, an injection pipe fixedly mounted through the inner wall of one side of the mixing pipe, and a sealing plug fixedly mounted inside the injection pipe; the mixing pipe is provided with a mixing screw for mixing the liquid, one end of which is connected to a conveying assembly, one side of which extends into the chassis and is connected to the top inner wall of one side of the chassis. The other end of the mixing pipe is fixedly equipped with a second discharge pipe, one end of which extends into the machine housing and is fixedly equipped with a support pipe. The support pipe is fixedly connected to a plurality of the connecting pipes respectively.
8. The heparin sodium mucosal enzymatic hydrolysate shaking device according to claim 7, characterized in that, The conveying assembly includes a connecting cylinder fixedly mounted on the outside of the chassis. Multiple liquid outlet pipes are fixedly mounted at equal intervals on the inner wall of the top of the connecting cylinder. The top of the liquid outlet pipe extends into the chassis and is fixedly connected to the inner wall of the chassis. A first discharge pipe is fixedly mounted on the inner wall of the bottom of the connecting cylinder. The bottom end of the first discharge pipe extends to one side of the chassis and is fixedly connected to one end of the mixing pipe.