Biological safety negative pressure pig isolator for experiment

Abstract

The invention discloses a biological safety negative pressure pig isolator for an experiment. The biological safety negative pressure pig isolator comprises an isolator body, a ventilation mechanism and an object taking mechanism. According to the experimental pig isolator, through the arrangement of the object taking mechanism, independent cavity isolation in the object taking cavity can be achieved, it is guaranteed that no substance interaction exists inside and outside the isolator, and when objects such as experimental tools are moved in or out of the isolator, synchronous and automatic object pushing and internal disinfection of the object taking cavity can be achieved; the cross contamination inside and outside the isolator during the use of experiment tools and the like is further avoided, the biological safety and the experiment operation safety are ensured, and meanwhile, the use convenience of the isolator is improved.

Description

Technical Field

[0001] The invention relates to the technical field of experimental animal isolators, in particular to a biosafety negative pressure pig isolator for experiments. Background Art

[0002] The daily feeding and experimental operations of experimental animals, such as pigs, are generally carried out in a sterile isolator. A sterile isolator is an important equipment used in experimental animal breeding and experimental fields. It creates a suitable growth environment for experimental animals that is isolated from the complex external environment by physical isolation, avoiding the interference of pathogens, bacteria, etc. in the external environment on the growth of experimental animals. When it is used, it is necessary to fully disinfect the experimental tools and other items that enter the isolator from the outside and are taken out of the isolator, as well as the contaminated air inside and outside the isolator. Taking the placement of materials into the isolator as an example, when the existing isolator for experimental animals is used, it is necessary to first manually separate the object-taking mechanism from the isolator and manually connect it to the docking device or the external environment. Then, the object is placed in the object-taking mechanism and disinfected from the contaminated air. Specifically, disinfectant is sprayed on the object in the cavity manually or through a spraying device to achieve disinfection. After the disinfection is completed, the object-taking mechanism is isolated from the docking device or the external environment and connected to the isolator, and the material is moved into the isolator. The above process is complicated and the isolator is inconvenient to use. If the laboratory staff does not operate in a standardized manner, it is very easy to cause incomplete disinfection of items or cross-contamination of the environment on both sides of the retrieval mechanism, affecting biosafety and experimental operation safety. Summary of the Invention

[0003] The purpose of the present invention is to provide a biosafety negative pressure pig isolator for experiments in order to solve the problem that the existing pig isolators for experiments are inconvenient to operate and affect the biosafety and experimental operation safety.

[0004] In order to achieve the above-mentioned purpose, the present invention adopts the following technical solution: a biosafety negative pressure pig isolator for experiments, comprising:

[0005] The isolator body is provided with a plurality of windows with operating gloves, and a first mesh plate is arranged inside the windows;

[0006] A ventilation mechanism, comprising an air inlet box and an air outlet box with a fan, wherein the air inlet box and the air outlet box are assembled on the isolator body and communicate with the inner cavity of the isolator body;

[0007] The picking mechanism includes a box body, a door body, a roller shaft, and an air supply impeller. The side of the box body is provided with at least two openings connected to the picking chamber therein, one of the openings is connected to the inner cavity of the isolator body, the door body is arranged on the opening, the roller shaft is driven to rotate and is arranged in the picking chamber, and a plurality of sealing plates are arranged at circumferential intervals on its side. The roller shaft and the sealing plates airtightly separate the picking chamber into two independent chambers. The side of the independent chamber is extended with a mounting groove, and the mounting groove is connected to the first joint on the box body through a flow channel. The air supply impeller is rotatably connected to the impeller frame in the mounting groove. The box body is also provided with a second joint connected to the picking chamber.

[0008] As a further description of the above technical solution:

[0009] The inner cavity of the isolator body is provided with a partition plate between the first mesh plates.

[0010] As a further description of the above technical solution:

[0011] The inner cavity of the isolator body is provided with a second mesh plate at the bottom of the first mesh plate, and the bottom of the isolator body is provided with a conical drainage bottom shell, and the drainage bottom shell is connected to the conveying pipeline of the sewage recovery equipment through the drainage port.

[0012] As a further description of the above technical solution:

[0013] The air inlet box and the air outlet box are both connected to the isolator body through a filter box with a built-in filter component.

[0014] As a further description of the above technical solution:

[0015] Guide rails are arranged on both sides of the inner cavity of the isolator body. The guide rails extend toward the object-taking mechanism, and a receiving tray is slidably arranged on the guide rails.

[0016] As a further description of the above technical solution:

[0017] The door body is an inward-opening door with one side hinged on the opening, and a limit plate extending from the side thereof abuts against the inner wall of the box body.

[0018] As a further description of the above technical solution:

[0019] A sealing gasket is provided on the outer side of the sealing plate and is in close contact with the inner wall of the box body.

[0020] As a further description of the above technical solution:

[0021] A gear groove extends from the side of the taking cavity, and the gears at both ends of the roller shaft are rotatably arranged in the gear groove, and the teeth on the gear abut against the blades on the air supply impeller.

[0022] As a further description of the above technical solution:

[0023] A sealing kit is provided on the teeth of the gear, and the sealing kit is in close contact with the inner wall of the gear groove. The sealing plate is parallel to the axis of one tooth of the gear, and the ends thereof are closely spliced ​​or fixed.

[0024] As a further description of the above technical solution:

[0025] A first magnet is provided on the roller shaft and / or the sealing plate, and the first magnet is magnetically connected to the second magnet on the box body.

[0026] In summary, due to the adoption of the above technical solution, the present invention has the following beneficial effects compared with the prior art:

[0027] The experimental pig isolator of the present invention can achieve independent cavity isolation in the retrieval cavity through the setting of the retrieval mechanism, ensuring that there is no interaction of substances inside and outside the isolator. When moving experimental tools and other items into or out of the isolator, the items can be pushed synchronously and automatically and the interior of the retrieval cavity can be disinfected, further avoiding cross-contamination inside and outside the isolator during the use of experimental tools, etc., ensuring biosafety and experimental operation safety, and at the same time, improving the convenience of using the isolator. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for use in the embodiments. It should be understood that the following drawings only illustrate certain embodiments of the present invention and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other relevant drawings can be obtained based on these drawings without paying any creative work.

[0029] Figure 1 This is a schematic diagram of the structure of an experimental biosafety negative pressure pig isolator.

[0030] Figure 2 A cross-sectional view of an experimental biosafety negative pressure pig isolator.

[0031] Figure 3 The usage status of the object-retrieving mechanism in an experimental biosafety negative pressure pig isolator Figure 1 .

[0032] Figure 4 The usage status of the object-retrieving mechanism in an experimental biosafety negative pressure pig isolator Figure 2 .

[0033] Figure 5 This is a schematic diagram of the structure of the roller, gear, and air supply impeller in an experimental biosafety negative pressure pig isolator.

[0034] Legend:

[0035] 1. Isolator body; 2. Window; 3. First mesh plate; 4. Air inlet box; 5. Air outlet box; 6. Retrieving mechanism; 7. Box body; 8. Opening; 9. Door body; 10. Retrieving chamber; 11. Roller; 12. Sealing plate; 13. Mounting slot; 14. Flow channel; 15. First joint; 16. Impeller frame; 17. Air supply impeller; 18. Second joint; 19. Partition plate; 20. Second mesh plate; 21. Drain bottom shell; 22. Drain port; 23. Waste recovery equipment; 24. Delivery pipeline; 25. Filter box; 26. Guide rail; 27. Receiving tray; 28. Limiting plate; 29. ​​Sealing gasket; 30. Gear slot; 31. Gear; 32. Sealing kit; 33. First magnet; 34. Second magnet. DETAILED DESCRIPTION

[0036] To make the objectives, technical solutions, and advantages of the embodiments of the present invention more clear, the technical solutions of the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, not all embodiments. Generally, the components of the embodiments of the present invention described and shown in the drawings herein can be arranged and designed in a variety of different configurations.

[0037] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the invention as claimed, but rather merely represents selected embodiments of the present invention. All other embodiments derived by persons of ordinary skill in the art based on the embodiments of the present invention without inventive effort shall fall within the scope of protection of the present invention.

[0038] It should be noted that similar reference numerals and letters denote similar items in the following drawings. Therefore, once an item is defined in one drawing, it does not need to be further defined or explained in the subsequent drawings.

[0039] In the description of the embodiments of the present invention, it should be noted that the terms "upper" and "inner" etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, or are orientations or positional relationships in which the inventive product is usually placed when in use. These are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation. Therefore, they should not be understood as limitations on the present invention.

[0040] In the description of the present invention, it should also be noted that, unless otherwise expressly specified or limited, the terms "disposed," "installed," "connected," and "connected" should be understood broadly. For example, they may refer to fixed connections, detachable connections, or integral connections; they may refer to direct connections, indirect connections through an intermediate medium, or internal communication between two components. Those skilled in the art will understand the specific meanings of the above terms in the present invention based on the specific circumstances.

[0041] See also Figure 1-5 The present invention provides a technical solution: a biosafety negative pressure pig isolator for experiments, comprising:

[0042] The isolator body 1 is provided with a plurality of windows 2 with operating gloves, and a first mesh plate 3 is arranged inside the windows;

[0043] A ventilation mechanism, comprising an air inlet box 4 and an air outlet box 5 with a fan, wherein the air inlet box 4 and the air outlet box 5 are assembled on the isolator body 1 and communicate with the inner cavity of the isolator body 1;

[0044] The picking mechanism 6 includes a box body 7, a door body 9, a roller shaft 11, and an air supply impeller 17. The side of the box body 7 is provided with at least two openings 8 connected to the picking chamber 10 therein, one of the openings 8 is connected to the inner cavity of the isolator body 1, and the door body 9 is arranged on the opening 8. The roller shaft 11 is driven to rotate and is arranged in the picking chamber 10. A plurality of sealing plates 12 are arranged at circumferential intervals on its side. The roller shaft 11 and the sealing plates 12 airtightly separate the picking chamber 10 into two independent chambers. A mounting groove 13 is extended on the side of the independent chamber. The mounting groove 13 is connected to the first joint 15 on the box body 7 through the flow channel 14. The air supply impeller 17 is rotatably connected to the impeller frame 16 in the mounting groove 13. The box body 7 is also provided with a second joint 18 connected to the picking chamber 10. The first connector 15 and the second connector 18 are connected to an external air circulation pipeline. The fan in the air circulation pipeline can realize bidirectional operation (the bidirectional operation of the fan is an existing technology and will not be described in detail here). The air circulation pipeline is also connected to a disinfectant liquid nozzle, and the disinfectant liquid is atomized through the disinfectant liquid nozzle, so that the atomized disinfectant liquid enters the sample collection chamber 10 along with the airflow in the air circulation pipeline, thereby realizing the disinfection of the internal air, experimental objects, etc., and ensuring the biological safety of use.

[0045] The inner cavity of the isolator body 1 is provided with a partition plate 19 between the first mesh plates 3 to separate the space inside the isolator body 1 and ensure that the growth of the experimental animals and the experiments do not interfere with each other.

[0046] The inner cavity of the isolator body 1 is provided with a second mesh plate 20 at the bottom of the first mesh plate 3, and a conical drainage bottom shell 21 is provided at the bottom of the isolator body 1. The drainage bottom shell 21 is connected to the conveying pipeline 24 of the waste recovery equipment 23 through the drainage port 22, thereby increasing the excrement and other pollutants of the experimental animal pigs in the isolator body 1, improving the internal cleanliness, and ensuring a suitable growth environment for experimental animals and the experimental environment.

[0047] The air inlet box 4 and the air outlet box 5 are both connected to the isolator body 1 through the filter box 25 with a built-in filter assembly. By adjusting the control valves (electric valves or manual valves) on the air inlet box 4 and the air outlet box 5, the negative pressure inside the isolator is ensured.

[0048] Guide rails 26 are provided on both sides of the inner cavity of the isolator body 1. The guide rails 26 extend toward the retrieval mechanism 6, and a receiving tray 27 is slidably mounted thereon. During use, laboratory instruments and other items can be placed on the receiving tray 27 and slid along the guide rails 26 to the corresponding position, facilitating experimental operations and the removal of the instrument from the isolator, thereby improving ease of use.

[0049] The door 9 is an inward-opening door hinged on one side to the opening 8, and a stopper plate 28 extends from its side to abut against the inner wall of the box 7. This prevents the door 9 from accidentally opening during disinfection of the retrieval mechanism 6, which could lead to cross-contamination between the internal and external environments of the isolator, affecting biosafety and experimental safety.

[0050] A gear groove 30 extends from the side of the extraction chamber 10 , and gears 31 at both ends of the roller shaft 11 are rotatably disposed in the gear groove 30 , and the teeth on the gear 31 abut against the blades on the air supply impeller 17 .

[0051] A sealing gasket 29 is provided on the outer side of the sealing plate 12, which is in close contact with the inner wall of the housing 7. A sealing kit 32 is provided on the teeth of the gear 31, which is in close contact with the inner wall of the gear groove 30. The sealing plate 12 is parallel to the axis of one tooth of the gear 31, and the ends are tightly joined or fixed. This ensures that when sterilizing airflow is not flowing into the extraction chamber 10, the roller 11 and the two sides of the sealing plate 12 are isolated from each other, corresponding to the inner cavity of the isolator body 1 and the external environment of the isolator, respectively, without material interaction, improving the airtightness of the structure and further ensuring biosafety and experimental operation safety.

[0052] A first magnet 33 is disposed on the roller 11 and / or the sealing plate 12, and is magnetically coupled to a second magnet 34 on the housing 7. This allows the roller 11 and sealing plate 12 to automatically rotate to a designated position under the magnetic effect when no sterilizing air is flowing into the extraction chamber 10. This ensures that the sealing plate 12 is in airtight contact with the inner wall of the extraction chamber 10, isolating the two sides of the chamber into separate cavities.

[0053] The working principle of the biosafety negative pressure pig isolator for experiments in this embodiment includes: when the experimental tools are moved into the isolator, Figure 3 , the roller 11 and the sealing plate 12 are automatically rotated to a vertical state by the magnetic effect, and the independent cavities on both sides are separated. At this time, the door body 9 on the side of the external environment is pushed inward, and the items are placed in the independent cavity on this side. After that, the door body 9 is released and it automatically closes at the opening 8; the item disinfection and transfer begins. Specifically, the fan in the air circulation pipeline is operated, so that the high-pressure, high-flow rate disinfection air flow enters the object-taking cavity 10 and drives the air supply impeller 17 to rotate, and the gear 31 is driven by the blades of the air supply impeller 17 (overcoming the magnetic effect) to rotate synchronously, and it rotates together with the roller 11 (both of which are lightweight structures) to connect the independent cavities on both sides. The disinfection air flow disinfects the air in the object-taking cavity 10 (the external polluted air and the polluted air in the isolator that enter the object-taking cavity 10 when the two door bodies 9 on both sides are opened) and the items, and pushes the experimental tools, etc. through the sealing plate 12 to move them to the independent cavity on the other side. Figure 4 As shown (wherein the solid arrow is the flow direction of the disinfection airflow, and the dotted arrow is the rotation direction of the air supply impeller 17); after the disinfection is completed, the disinfection airflow stops entering. At this time, the thrust acting on the air supply impeller 17 is removed, and the roller 11 and the sealing plate 12 are automatically rotated to a vertical state by the magnetic effect, and the separation of the independent cavities on both sides is realized again. After that, the door 9 on one side of the isolator can be opened to move the disinfected laboratory tools and the like into the isolator. The workflow for moving items out of the isolator is the same as the principle of the above process, except that the fan in the air circulation pipeline runs in the reverse direction, which can realize the reverse rotation of the gear 31, the roller 11, and the sealing plate 12 to realize the outward push of the items. After that, the laboratory staff can take out the disinfected items from the door 9 on the side of the external environment.

[0054] In summary, due to the adoption of the above technical solution, the experimental biosafety negative pressure pig isolator of this embodiment has the following beneficial effects compared with the prior art:

[0055] The experimental pig isolator of the present invention can achieve independent cavity isolation in the retrieval cavity through the setting of the retrieval mechanism, ensuring that there is no interaction of substances inside and outside the isolator. When moving experimental tools and other items into or out of the isolator, the items can be pushed synchronously and automatically and the interior of the retrieval cavity can be disinfected, further avoiding cross-contamination inside and outside the isolator during the use of experimental tools, etc., ensuring biosafety and experimental operation safety, and at the same time, improving the convenience of using the isolator.

[0056] The above description is only a preferred specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any technician familiar with the technical field, within the technical scope disclosed by the present invention, who makes equivalent replacements or changes based on the technical solution and inventive concept of the present invention, should be covered by the scope of protection of the present invention.

Claims

1. A biosafety negative pressure pig isolator for experiments, characterized in that: include: The isolator body is provided with a plurality of windows with operating gloves, and a first mesh plate is arranged inside the windows; A ventilation mechanism, comprising an air inlet box and an air outlet box with a fan, wherein the air inlet box and the air outlet box are assembled on the isolator body and communicate with the inner cavity of the isolator body; The picking mechanism includes a box body, a door body, a roller shaft, and an air supply impeller. The side of the box body is provided with at least two openings connected to the picking chamber therein, one of the openings is connected to the inner cavity of the isolator body, the door body is arranged on the opening, the roller shaft is driven to rotate and is arranged in the picking chamber, and a plurality of sealing plates are arranged at circumferential intervals on its side. The roller shaft and the sealing plates airtightly separate the picking chamber into two independent chambers. The side of the independent chamber is extended with a mounting groove, and the mounting groove is connected to the first joint on the box body through a flow channel. The air supply impeller is rotatably connected to the impeller frame in the mounting groove. The box body is also provided with a second joint connected to the picking chamber.

2. The experimental biosafety negative pressure pig isolator according to claim 1, characterized in that: The inner cavity of the isolator body is provided with a partition plate between the first mesh plates.

3. The experimental biosafety negative pressure pig isolator according to claim 1, characterized in that: The inner cavity of the isolator body is provided with a second mesh plate at the bottom of the first mesh plate, and the bottom of the isolator body is provided with a conical drainage bottom shell, and the drainage bottom shell is connected to the conveying pipeline of the sewage recovery equipment through the drainage port.

4. The experimental biosafety negative pressure pig isolator according to claim 1, characterized in that: The air inlet box and the air outlet box are both connected to the isolator body through a filter box with a built-in filter component.

5. The experimental biosafety negative pressure pig isolator according to claim 1, characterized in that: Guide rails are arranged on both sides of the inner cavity of the isolator body. The guide rails extend toward the object-taking mechanism, and a receiving tray is slidably arranged on the guide rails.

6. The experimental biosafety negative pressure pig isolator according to claim 1, characterized in that: The door body is an inward-opening door with one side hinged on the opening, and a limit plate extending from the side thereof abuts against the inner wall of the box body.

7. The experimental biosafety negative pressure pig isolator according to claim 1, characterized in that: A sealing gasket is provided on the outer side of the sealing plate and is in close contact with the inner wall of the box body.

8. The experimental biosafety negative pressure pig isolator according to claim 1, characterized in that: A gear groove extends from the side of the taking cavity, and the gears at both ends of the roller shaft are rotatably arranged in the gear groove, and the teeth on the gear abut against the blades on the air supply impeller.

9. The experimental biosafety negative pressure pig isolator according to claim 8, characterized in that: A sealing kit is provided on the teeth of the gear, and the sealing kit is in close contact with the inner wall of the gear groove. The sealing plate is parallel to the axis of one tooth of the gear, and the ends thereof are closely spliced ​​or fixed.

10. The experimental biosafety negative pressure pig isolator according to claim 1, characterized in that: A first magnet is provided on the roller shaft and / or the sealing plate, and the first magnet is magnetically connected to the second magnet on the box body.

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