Liquid crystal bionic water-locking and oxygen-permeating nursing composition as well as preparation method and application thereof

Abstract

The invention provides a liquid crystal bionic water-locking and oxygen-permeating nursing composition as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. The skin care product is prepared from components in percentage by weight as follows: 20%-40% of glycerin, 5%-10% of hydrogenated lecithin, 5%-10% of phytosterols, 0.1%-0.5% of sodium stearoyl glutamate, 0.01%-0.05% of sodium methyl stearoyl taurate, 0.1%-1% of ceramide NP, 1%-10% of caprylic / capric triglyceride, 1%-10% of squalane, 0.1%-1% of tocopheryl acetate, 0.01%-0.3% of DNA sodium, 0.001%-0.1% of fibronectin and the balance of water. 0.001-0.1% of soluble collagen and the balance of water. The liquid crystal bionic water-locking and oxygen-permeating nursing composition provided by the invention can better form a breathable protective film on the surface of skin, reduce water loss of the skin and help to repair a damaged skin barrier, so that the water-locking and oxygen-permeating nursing effect is achieved.

Description

Technical Field

[0001] The present invention belongs to the technical field of cosmetics, and in particular relates to a liquid crystal biomimetic water-locking and oxygen-permeable care composition, a preparation method thereof, and an application thereof. Background Art

[0002] With the increasing research on the physiological structure and mechanisms of the skin, people's understanding of the skin barrier has continued to deepen, and they are increasingly aware that a healthy skin barrier is the most important factor in maintaining skin health. The most common skin manifestation caused by a damaged skin barrier is sensitive skin. At the same time, most skin diseases also involve a damaged skin barrier, such as acne, seborrheic dermatitis, melasma, rosacea, and hormone-dependent dermatitis.

[0003] Human skin is a metabolic system, and the skin barrier also interacts and influences each other in multiple dimensions and angles, from the outermost sebum membrane, to the most important brick wall structure, to moisture regulation mechanisms such as aquaporins and natural moisturizing factors, to inflammation and immune regulation mechanisms, and finally to the activation and remodeling of the dermis. Each level has a perfect regulation mechanism. Problems in any link will induce problems in other links, thus forming a vicious circle.

[0004] Vernix caseosa is a natural biological protective membrane covering the surface of fetal skin. It not only effectively shields the alkaline environment of amniotic fluid from pollutants, but also protects and promotes fetal skin development. Recent research progress in the composition, efficacy, and simulated applications of vernix caseosa has revealed its moisturizing, antibacterial, and epidermal barrier properties, effectively mitigating blue light damage to human skin. However, because natural vernix caseosa cannot be used directly to create skincare products, the majority of existing vernix caseosa-based skincare products are formulated using biomimetic vernix caseosa.

[0005] For example, Chinese patent CN115501138A discloses a biomimetic vernix caseosa composition, preparation method, and application. The biomimetic vernix caseosa composition consists of three phases: A, B, and C. Phase A consists of hydrogenated lecithin, glycerol, biosaccharide gum-2, sodium hyaluronate, and deionized water; Phase B consists of ceramide-3, cholesterol, beeswax, stearic acid, caprylic / capric triglyceride, squalane, prickle oil, and tocopherol; and Phase C consists of superoxide dismutase, tripeptide-1 copper, kava extract, capsicum fruit extract, Agave taequatica leaf extract, and bifid yeast fermentation lysate. This biomimetic vernix caseosa composition can better repair the skin barrier and increase skin resistance.

[0006] For example, Chinese patent CN117122533B discloses a biomimetic vernix caseosa composition, its preparation method, and application. The biomimetic vernix caseosa composition comprises the following components, by mass: 0.1-5% pentacyclic triterpenoids, 9.8-50% vegetable oils and fats, 10-30% isolated and purified vegetable oil components, 30-70% vegetable oil derivatives, and 0.1-5% plant-derived ceramides. This biomimetic vernix caseosa composition significantly enhances skin protection and repair, strengthening skin's resilience. The biomimetic vernix caseosa membrane prepared from this biomimetic vernix caseosa composition exhibits a well-defined liquid crystal structure similar to that of natural vernix caseosa, demonstrating promising application prospects.

[0007] However, the long-term moisturizing and water-locking effect and stability of existing bionic skin care compositions cannot meet the needs well. Therefore, it is necessary to develop a liquid crystal bionic water-locking and oxygen-permeable care composition with good long-term moisturizing and water-locking effect and high stability for repairing damaged skin barriers and a preparation method thereof. Summary of the Invention

[0008] Based on the deficiencies in the prior art, the present invention aims to provide a liquid crystal biomimetic water-locking and oxygen-permeable care composition with good long-term moisturizing and water-locking effects and high stability for repairing damaged skin barriers, as well as a preparation method and application thereof.

[0009] In order to achieve the above object, the present invention adopts the following technical solutions:

[0010] A liquid crystal biomimetic water-locking and oxygen-permeable care composition comprises the following components, measured by weight percentage: 20-40% glycerol, 5-10% hydrogenated lecithin, 5-10% phytosterols, 0.1-0.5% sodium stearoyl glutamate, 0.01-0.05% sodium methyl stearoyl taurate, 0.1-1% ceramide NP, 1-10% caprylic / capric triglyceride, 1-10% squalane, 0.1-1% tocopheryl acetate, 0.01-0.3% sodium DNA, 0.001-0.1% fibronectin, 0.001-0.1% soluble collagen, and the balance water.

[0011] Preferably, the liquid crystal biomimetic water-locking and oxygen-permeable care composition is composed of the following components by weight percentage: 22-38% glycerol, 6-8% hydrogenated lecithin, 6-8% phytosterols, 0.2-0.4% sodium stearoyl glutamate, 0.02-0.04% sodium methyl stearoyl taurate, 0.3-0.8% ceramide NP, 3-8% caprylic / capric triglyceride, 3-8% squalane, 0.3-0.8% tocopheryl acetate, 0.05-0.25% sodium DNA, 0.005-0.08% fibronectin, 0.005-0.08% soluble collagen and the balance water.

[0012] More preferably, the liquid crystal biomimetic water-locking and oxygen-permeable care composition is composed of the following components by weight percentage: 25-35% glycerol, 7-8% hydrogenated lecithin, 7-8% phytosterols, 0.25-0.35% sodium stearoyl glutamate, 0.025-0.035% sodium methyl stearoyl taurate, 0.5-0.7% ceramide NP, 4-6% caprylic / capric triglyceride, 4-6% squalane, 0.4-0.7% tocopheryl acetate, 0.1-0.2% sodium DNA, 0.01-0.05% fibronectin, 0.01-0.05% soluble collagen and the balance water.

[0013] The phytosterols are preferably β-sitosterol.

[0014] Among the above components:

[0015] Glycerin: It can be used as a solvent to help dissolve other ingredients; in addition, as a moisturizing ingredient, it can lock in skin moisture and keep the skin hydrated; secondly, it can also be used as a carrier matrix for the preparation of liquid crystal emulsifiers.

[0016] Hydrogenated lecithin: retains the biocompatibility of natural lecithin and serves as a carrier for liposome raw materials. By encapsulating the raw materials, it enhances output targeting and promotes the permeability of effective ingredients. It also has both emulsifying and moisturizing functions, and is compounded with glycerin and phytosterols to form a liquid crystal emulsifier. It has a strong affinity for skin and mucous membranes and can be absorbed by human skin and hair. At the same time, it moisturizes the skin or hair and can promote the penetration of other nutrients.

[0017] Phytosterols: They have hydrophilic and lipophilic groups and are compounded with glycerol and lecithin to form liquid crystal emulsifiers. They have a similar structure to human skin and are light and easily absorbed. They form a barrier on the skin surface, reducing water loss while promoting wound healing. They relieve skin inflammation and allergic reactions and are suitable for sensitive skin or after-sunburn care. They inhibit excessive secretion of sebaceous glands and improve oily skin conditions. They have high skin permeability, can promote skin metabolism, inhibit skin inflammation, and also have the effect of repairing sun erythema and delaying skin aging.

[0018] Sodium stearoyl glutamate: an oil-in-water (O / W) emulsifier that maintains good surface activity and stability in hard water environments. It is not affected by metal ions such as calcium and magnesium in the water and can perform its cleaning and emulsification functions normally. It is highly biodegradable and easily decomposes in the environment without causing environmental pollution, in line with the concept of green environmental protection. It is mild and non-irritating, suitable for people with dry and sensitive skin.

[0019] Sodium Methyl Stearoyl Taurate: An oil-in-water (O / W) emulsifier that maintains good surface activity and stability in hard water environments. It is safe, non-irritating to the skin, highly biodegradable, and easily decomposes in the environment without causing environmental pollution, in line with the concept of green environmental protection. It is mild and non-irritating, suitable for people with dry and sensitive skin.

[0020] Ceramide NP: Fills the gaps between stratum corneum cells and forms a "brick wall structure" together with cholesterol and free fatty acids to prevent water loss, replenish missing lipids, accelerate barrier repair, and resist external stimuli; reduces skin inflammation, relieves sensitive symptoms such as redness and itching, and is especially suitable for sensitive skin or post-medical beauty repair; enhances skin elasticity, reduces the formation of fine lines, and delays skin aging caused by decreased barrier function; exists naturally in the skin and is non-irritating; used in liposome encapsulation technology to improve permeability.

[0021] Caprylic / Capric Triglyceride: Compatible with human skin, has a non-greasy texture, and has a lubricating and softening effect.

[0022] Squalane: Naturally derived, with a stable molecular structure and high compatibility with human skin lipids, it can quickly penetrate the skin to form a thin protective film that is light and non-sticky. It can improve the skin's absorbency, making the skin feel smooth and not clogging pores. It can inhibit the damage of free radicals to the skin and help delay skin aging. It can replenish skin lipids, enhance the barrier function of the stratum corneum, and improve problems such as sensitivity and redness caused by damaged barriers. It can reduce skin inflammation and relieve irritation, while neutralizing free radicals and reducing damage to the skin from ultraviolet rays, pollution, etc.

[0023] Tocopheryl acetate: neutralizes free radicals, reduces damage to the skin caused by ultraviolet rays, pollution, etc., and delays collagen loss; releases tocopherol after penetrating the skin, enhances the stratum corneum's ability to lock in moisture, improves dryness and roughness; relieves skin inflammation and redness.

[0024] Sodium DNA: It can reduce the overreaction of sensitive skin to external stimuli, relieve sensitive symptoms, regulate skin microcirculation, reduce redness, inhibit acne inflammatory response, promote acne repair, and promote the regeneration of various growth factors, which helps to rebuild the skin barrier function; it can secrete a small amount of collagen and non-collagen substances, continuously stimulate fibroblasts to secrete extracellular matrix, increase the regeneration of collagen, elastic fibers, and reticular fibers, reduce wrinkles, and improve skin firmness; it remediates DNA damage by recycling and integrating bases and nucleosides, accelerates the repair of damaged cells, promotes wound healing, and accelerates cell metabolism.

[0025] Fibronectin: It has anti-inflammatory properties, can regulate the activity of inflammatory cells, inhibit the release of inflammatory factors, participate in wound healing and tissue repair, mobilize the mononuclear phagocyte system to remove harmful substances from damaged tissues, and stimulate cell migration, adhesion and proliferation, promoting the regeneration of damaged tissues.

[0026] Soluble collagen: The hydrophilic groups in the molecule can form hydrogen bonds with water molecules, adsorbing and locking in a large amount of moisture, so that the skin's stratum corneum remains well hydrated; forming a breathable protective film on the skin surface, reducing water loss from the skin, and helping to repair damaged skin barriers; directly replenishing the collagen needed by the skin, filling the gaps between skin cells, stimulating the activity of skin fibroblasts, promoting the synthesis of more collagen and elastic fibers, and restoring the skin's youthful state; inhibiting tyrosinase activity, reducing melanin formation, promoting skin cell metabolism, and accelerating the shedding of melanin from the skin's surface; having anti-inflammatory properties, can reduce skin inflammatory reactions, relieve skin redness, swelling, itching and other discomfort symptoms, promote skin cell proliferation and differentiation, and accelerate wound healing.

[0027] As a preferred embodiment, the mass ratio of glycerol, hydrogenated lecithin and phytosterols is 2-4:0.5-1:0.5-1;

[0028] More preferably, the mass ratio of the glycerol, hydrogenated lecithin and phytosterols is 2.5-3.5:0.6-0.8:0.6-0.8;

[0029] Further preferably, the mass ratio of the glycerol, hydrogenated lecithin and phytosterols is 3.2:0.8:0.8.

[0030] During the implementation of the present invention, it was found that controlling the mass ratio of glycerol, hydrogenated lecithin and phytosterols can better compound the three to form a liquid crystal emulsifier, which has a similar structure to human skin and is light and easily absorbed; it forms a barrier on the skin surface, reduces water loss, and promotes wound healing.

[0031] As another preferred embodiment, the mass ratio of DNA sodium, fibronectin and soluble collagen is 10-20:1-5:1-5;

[0032] More preferably, the mass ratio of DNA sodium, fibronectin and soluble collagen is 12-18:2-4:2-4;

[0033] Further preferably, the mass ratio of DNA sodium, fibronectin and soluble collagen is 15:3:3.

[0034] During the implementation of the present invention, it was found that by controlling the mass ratio of DNA sodium, fibronectin and soluble collagen, a breathable protective film can be better formed on the skin surface, reducing skin moisture loss and helping to repair damaged skin barriers, thereby achieving the effect of water-locking and oxygen-permeable care.

[0035] The mass ratio of sodium stearoyl glutamate to sodium methyl stearoyl taurate is 5-20:1; preferably 8-15:1; more preferably 10:1.

[0036] During the implementation of the present invention, it was unexpectedly discovered that adding sodium stearoyl glutamate and sodium methyl stearoyl taurate to the components and controlling the mass ratio of the two to be 5-20:1 can significantly improve the stability of the product; and compounding them with glycerol, hydrogenated lecithin and plant sterols, as well as sodium DNA, fibronectin and soluble collagen can significantly improve the hydrating and water-locking effect of the composition, and the composition is refreshing, not heavy, and has good air permeability.

[0037] As a preferred embodiment, the liquid crystal biomimetic water-locking and oxygen-permeable care composition is composed of the following components by weight percentage: 32% glycerol, 8% hydrogenated lecithin, 8% phytosterols, 0.3% sodium stearoyl glutamate, 0.03% sodium methyl stearoyl taurate, 0.6% ceramide NP, 5% caprylic / capric triglyceride, 5% squalane, 0.6% tocopheryl acetate, 0.15% sodium DNA, 0.03% fibronectin, 0.03% soluble collagen and the balance water.

[0038] The present invention also provides a method for preparing the liquid crystal biomimetic water-locking and oxygen-permeable care composition, comprising the following steps:

[0039] (1) Glycerin, hydrogenated lecithin, phytosterols, sodium stearoyl glutamate, and sodium methyl stearoyl taurate are mixed, heated to 85-90° C., and stirred for 10-15 minutes to obtain a liquid crystal emulsifier base A;

[0040] (2) ceramide NP, caprylic / capric triglyceride, squalane, and tocopheryl acetate were mixed and stirred to obtain solution B;

[0041] (3) Add sodium DNA, fibronectin, and soluble collagen to water and disperse them evenly to obtain solution C;

[0042] (4) Preserving the liquid crystal emulsifier base material A at 85-90°C, slowly adding solution B under stirring, stirring and dispersing evenly, and then maintaining the temperature for 20 minutes to obtain a mixed solution;

[0043] (5) Slowly add solution C to the mixed solution, then perform high-speed emulsification and homogenization for 10 minutes, continue stirring at a constant temperature for 20 minutes, cool to 45°C and stir evenly to obtain the liquid crystal biomimetic water-locking and oxygen-permeable care composition.

[0044] The present invention also provides the use of the liquid crystal bionic water-locking and oxygen-permeable care composition in the preparation of bionic water-locking and oxygen-permeable care cosmetics.

[0045] The bionic water-locking and oxygen-permeable care cosmetics include skin care products, hair care products or washing products.

[0046] Compared with the prior art, the present invention has the following beneficial effects:

[0047] (1) The present invention adds phytosterols to the components, and unexpectedly finds that controlling the mass ratio of glycerol, hydrogenated lecithin and phytosterols can better compound the three to form a liquid crystal emulsifier, which is similar to the structure of human skin, has a light skin feel and is easily absorbed; forms a barrier on the skin surface, reduces water loss, and promotes wound healing.

[0048] (2) During the implementation of the present invention, it was found that by controlling the mass ratio of DNA sodium, fibronectin and soluble collagen, a breathable protective film can be better formed on the skin surface, reducing skin moisture loss and helping to repair damaged skin barriers, thereby achieving the effect of locking in moisture and allowing oxygen to pass through the skin.

[0049] (3) The present invention adds sodium stearoyl glutamate and sodium methyl stearoyl taurate to the components and controls the mass ratio of the two to be 5-20:1, which can significantly improve the stability of the product; and compounding them with glycerol, hydrogenated lecithin and plant sterols, as well as sodium DNA, fibronectin and soluble collagen can significantly improve the hydrating and water-locking effect of the composition, and it is refreshing, not heavy, and has good air permeability. BRIEF DESCRIPTION OF THE DRAWINGS

[0050] Figure 1 This is a diagram of the organizational structure of the liquid crystal biomimetic water-locking and oxygen-permeable care composition prepared in Example 4 (scale bar is 20 μm). DETAILED DESCRIPTION

[0051] The following is a clear and complete description of the technical solutions in the embodiments of the present invention, in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. All other embodiments obtained by ordinary technicians in this field based on the embodiments of the present invention without making any creative efforts are within the scope of protection of the present invention.

[0052] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art to which this invention pertains. The terms used in this specification of the present invention are for the purpose of describing specific embodiments only and are not intended to limit the present invention. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0053] The following are the manufacturers and models of the raw materials used, see Table 1 below.

[0054] Table 1

[0055]

[0056]

[0057] Example 1 A liquid crystal biomimetic water-locking and oxygen-permeable care composition and its preparation method

[0058] The composition is as follows by weight: 20% glycerol, 5% hydrogenated lecithin, 5% β-sitosterol, 0.1% sodium stearoyl glutamate, 0.02% sodium methyl stearoyl taurate, 0.2% ceramide NP, 2.5% caprylic / capric triglyceride, 1.5% squalane, 0.2% tocopheryl acetate, 0.02% sodium DNA, 0.002% fibronectin, 0.002% soluble collagen and the balance is water.

[0059] Preparation method:

[0060] (1) Glycerin, hydrogenated lecithin, β-sitosterol, sodium stearoyl glutamate, and sodium methyl stearoyl taurate were mixed, heated to 85-90° C., and stirred for 15 minutes to obtain a liquid crystal emulsifier base A;

[0061] (2) ceramide NP, caprylic / capric triglyceride, squalane, and tocopheryl acetate were mixed and stirred to obtain solution B;

[0062] (3) Add sodium DNA, fibronectin, and soluble collagen to water and disperse them evenly to obtain solution C;

[0063] (4) Preserving the liquid crystal emulsifier base material A at 85-90°C, slowly adding solution B under stirring, stirring and dispersing evenly, and then maintaining the temperature for 20 minutes to obtain a mixed solution;

[0064] (5) Slowly add solution C to the mixed solution, then perform high-speed emulsification and homogenization for 10 minutes, continue stirring at a constant temperature for 20 minutes, cool to 45°C and stir evenly to obtain the liquid crystal biomimetic water-locking and oxygen-permeable care composition.

[0065] Example 2 A liquid crystal biomimetic water-locking and oxygen-permeable care composition and its preparation method

[0066] The composition is as follows by weight: 40% glycerol, 10% hydrogenated lecithin, 10% β-sitosterol, 0.5% sodium stearoyl glutamate, 0.04% sodium methyl stearoyl taurate, 1% ceramide NP, 10% caprylic / capric triglyceride, 10% squalane, 1% tocopheryl acetate, 0.3% sodium DNA, 0.1% fibronectin, 0.1% soluble collagen and the balance is water.

[0067] Preparation method:

[0068] (1) Glycerin, hydrogenated lecithin, β-sitosterol, sodium stearoyl glutamate, and sodium methyl stearoyl taurate were mixed, heated to 85-90° C., and stirred for 15 minutes to obtain a liquid crystal emulsifier base A;

[0069] (2) ceramide NP, caprylic / capric triglyceride, squalane, and tocopheryl acetate were mixed and stirred to obtain solution B;

[0070] (3) Add sodium DNA, fibronectin, and soluble collagen to water and disperse them evenly to obtain solution C;

[0071] (4) Preserving the liquid crystal emulsifier base material A at 85-90°C, slowly adding solution B under stirring, stirring and dispersing evenly, and then maintaining the temperature for 20 minutes to obtain a mixed solution;

[0072] (5) Slowly add solution C to the mixed solution, then perform high-speed emulsification and homogenization for 10 minutes, continue stirring at a constant temperature for 20 minutes, cool to 45°C and stir evenly to obtain the liquid crystal biomimetic water-locking and oxygen-permeable care composition.

[0073] Example 3 A liquid crystal biomimetic water-locking and oxygen-permeable care composition and its preparation method

[0074] The composition is as follows by weight: glycerol 25%, hydrogenated lecithin 6%, β-sitosterol 6%, sodium stearoyl glutamate 0.4%, sodium methyl stearoyl taurate 0.05%, ceramide NP 0.6%, caprylic / capric triglyceride 4%, squalane 8%, tocopheryl acetate 0.3%, sodium DNA 0.25%, fibronectin 0.03%, soluble collagen 0.04% and the balance is water.

[0075] Preparation method:

[0076] (1) Glycerin, hydrogenated lecithin, β-sitosterol, sodium stearoyl glutamate, and sodium methyl stearoyl taurate were mixed, heated to 85-90° C., and stirred for 15 minutes to obtain a liquid crystal emulsifier base A;

[0077] (2) ceramide NP, caprylic / capric triglyceride, squalane, and tocopheryl acetate were mixed and stirred to obtain solution B;

[0078] (3) Add sodium DNA, fibronectin, and soluble collagen to water and disperse them evenly to obtain solution C;

[0079] (4) Preserving the liquid crystal emulsifier base material A at 85-90°C, slowly adding solution B under stirring, stirring and dispersing evenly, and then maintaining the temperature for 20 minutes to obtain a mixed solution;

[0080] (5) Slowly add solution C to the mixed solution, then perform high-speed emulsification and homogenization for 10 minutes, continue stirring at a constant temperature for 20 minutes, cool to 45°C and stir evenly to obtain the liquid crystal biomimetic water-locking and oxygen-permeable care composition.

[0081] Example 4 A liquid crystal biomimetic water-locking and oxygen-permeable care composition and its preparation method

[0082] The composition is as follows by weight: 32% glycerol, 8% hydrogenated lecithin, 8% β-sitosterol, 0.3% sodium stearoyl glutamate, 0.03% sodium methyl stearoyl taurate, 0.6% ceramide NP, 5% caprylic / capric triglyceride, 5% squalane, 0.6% tocopheryl acetate, 0.15% sodium DNA, 0.03% fibronectin, 0.03% soluble collagen and the balance is water.

[0083] Preparation method:

[0084] (1) Glycerin, hydrogenated lecithin, β-sitosterol, sodium stearoyl glutamate, and sodium methyl stearoyl taurate were mixed, heated to 85-90° C., and stirred for 15 minutes to obtain a liquid crystal emulsifier base A;

[0085] (2) ceramide NP, caprylic / capric triglyceride, squalane, and tocopheryl acetate were mixed and stirred to obtain solution B;

[0086] (3) Add sodium DNA, fibronectin, and soluble collagen to water and disperse them evenly to obtain solution C;

[0087] (4) Preserving the liquid crystal emulsifier base material A at 85-90°C, slowly adding solution B under stirring, stirring and dispersing evenly, and then maintaining the temperature for 20 minutes to obtain a mixed solution;

[0088] (5) Slowly add solution C to the mixed solution, then perform high-speed emulsification and homogenization for 10 minutes, continue stirring at a constant temperature for 20 minutes, cool to 45°C and stir evenly to obtain the liquid crystal biomimetic water-locking and oxygen-permeable care composition.

[0089] Comparative Example 1:

[0090] The difference from Example 4 is that sodium stearoyl glutamate is not added, and sodium stearoyl glutamate is replaced by sodium methyl stearoyl taurate, that is, 0.33% sodium methyl stearoyl taurate, and the other components and contents are the same as those in Example 4. Sodium stearoyl glutamate is not added during the preparation process.

[0091] Comparative Example 2:

[0092] The difference from Example 4 is that sodium stearoyl glutamate is replaced by stearyl alcohol, 0.3% stearyl alcohol and 0.03% sodium methyl stearoyl taurate, and the other components and contents are the same as those in Example 4. Stearyl alcohol is added during the preparation process.

[0093] Comparative Example 3:

[0094] The difference from Example 4 is that the mass ratio of sodium stearoyl glutamate to sodium methyl stearoyl taurate is 1:10, that is, 0.03% sodium stearoyl glutamate and 0.3% sodium methyl stearoyl taurate, and the other components and contents are the same as those in Example 4. The preparation process is the same as that in Example 4.

[0095] Comparative Example 4:

[0096] The difference from Example 4 is that the preparation method is different, specifically:

[0097] (1) Glycerin, hydrogenated lecithin, and β-sitosterol were mixed, heated to 85-90° C., and stirred for 15 minutes to obtain a liquid crystal emulsifier base A;

[0098] (2) Sodium stearoyl glutamate and sodium methyl stearoyl taurate were mixed, heated to 85-90° C., and stirred for 10 minutes to obtain a mixture B;

[0099] (3) ceramide NP, caprylic / capric triglyceride, squalane, and tocopheryl acetate were mixed and stirred to obtain solution C;

[0100] (3) Add sodium DNA, fibronectin, and soluble collagen to water and disperse them evenly to obtain solution D;

[0101] (4) Preserving the liquid crystal emulsifier base material A at 85-90°C, slowly adding the mixture B and solution C under stirring, stirring and dispersing them evenly, and then maintaining the temperature for 20 minutes to obtain a mixed solution;

[0102] (5) Solution D is slowly added to the mixed solution, and then high-speed emulsification and homogenization are performed for 10 minutes. After continuing to stir at a constant temperature for 20 minutes, the temperature is lowered to 45° C. and stirred evenly to obtain the liquid crystal biomimetic water-locking and oxygen-permeable care composition.

[0103] Comparative Example 5:

[0104] The difference from Example 4 is that the mass ratio of glycerol, hydrogenated lecithin and β-sitosterol is 14:1:1, that is, 42% glycerol, 3% hydrogenated lecithin, and 3% β-sitosterol, and the other components and contents are the same as those in Example 4. The preparation process is the same as that in Example 4.

[0105] Effect experiment:

[0106] 1. Stability testing

[0107] The products prepared in Examples 1-4 and Comparative Examples 1-4 were subjected to stability testing at constant temperatures of 50°C, 37°C, 25°C, 4°C, and -10°C, as well as at a cycling temperature of -10-45°C. The stability of the products was recorded after one day, three weeks, one month, and three months. Acceptable products showed no precipitation, odor, or discoloration, and no significant changes in viscosity or pH. A √ indicates normal; an × indicates changes in one or more of the following: odor, color, uniformity, viscosity, or pH. The test results are shown in Table 2.

[0108] Table 2

[0109]

[0110]

[0111] As shown in Table 2, when the compositions prepared in Examples 1-4 of the present invention were subjected to stability tests at 50°C, 37°C, 25°C, 4°C, and -10°C, as well as a cycle temperature of -10-45°C, no precipitation, odor, or discoloration occurred in the samples after 3 months, and no significant changes in viscosity and pH were observed, indicating that the compositions prepared in Examples 1-4 have good stability.

[0112] In Comparative Examples 1-3, changing the types or mass ratios of the components, that is, adding only sodium stearoyl glutamate as the surfactant component, or replacing sodium stearoyl glutamate with octadecyl alcohol (other types of surfactants), or changing the mass ratio of sodium stearoyl glutamate and sodium methyl stearoyl taurate will affect the formation of the network structure during the preparation process of the liquid crystal composition, thereby affecting the stability of the composition, so that the obtained composition changes in product performance in the third month or the sixth month under the conditions of cycling at 50°C, 37°C, -10°C and -10-45°C, that is, the stability test fails, indicating that the stability of the compositions prepared in Comparative Examples 1-3 is poor.

[0113] In Comparative Example 4, the preparation method was changed, that is, sodium stearoyl glutamate and sodium methyl stearoyl taurate were mixed separately and then mixed with other components. As a result, the liquid crystal emulsion could not be formed better during the preparation process of the composition, thereby affecting the stability of the composition. As a result, the product performance of the composition changed in the third month, the sixth month, or even the third week under the conditions of cycling at 50°C, 37°C, -4°C, -10°C, and -10-45°C, i.e., the stability test failed, indicating that the stability of the composition prepared in Comparative Example 4 was the worst.

[0114] 2. Moisturizing and barrier repair effect test

[0115] Test method: Recruit 70 volunteers, female aged 35-45 years old, who meet the subject inclusion and exclusion criteria of the "Technical Specifications for Safety of Cosmetics".

[0116] Volunteers were randomly divided into 10 groups, and the compositions prepared by Examples 1-4, Comparative Examples 1-2 and Comparative Example 5 were used respectively.

[0117] Corneometer CM825 (Courage Khazaka, Germany) was used to test the moisture content of the stratum corneum, and Tewameter™ Hex was used to test the transepidermal water loss rate.

[0118] Apply 10 mg of the composition evenly on the cheeks of the subjects, once in the morning and once in the evening, for 4 consecutive weeks. Before the test, the subjects cleaned their faces and rested in a constant temperature and humidity chamber for 30 minutes.

[0119] The formula for calculating the relative increase in stratum corneum moisture content is: Relative stratum corneum moisture increase (%) = (post-application value - pre-application value) / pre-application value × 100%. A greater relative stratum corneum moisture increase (%) indicates greater hydration.

[0120] The formula for calculating the TEWL improvement rate (%) is: TEWL improvement rate (%) = (1 - post-application value / pre-application value) × 100%. A greater TEWL improvement rate (%) indicates a better moisturizing effect. TEWL is a key parameter for assessing the function of the skin's water barrier, and can be used to evaluate the strength of the skin's barrier function. Lower TEWL indicates stronger skin barrier repair. Results are rounded to one decimal point. See Table 3 below for the test results.

[0121] And rate the user experience after use, the evaluation criteria are:

[0122] Breathability: score 0 to 5 points, 0 points means very poor breathability; 5 points means good breathability, and the average value is taken, with one decimal place rounded;

[0123] Grease: Score 0-5 points, 0 points for strong greasiness; 5 points for lightness and low greasiness. The average value is taken and rounded to one decimal place.

[0124] Skin firmness: Level 1: Skin firming effect is significantly improved, and wrinkles are significantly improved; Level 2: Skin firming effect is moderately improved, and wrinkle improvement is moderate; Level 3: Skin firming effect is not improved, and wrinkles are not improved.

[0125] The test results are shown in Table 4 below.

[0126] Table 3

[0127] Relative increase in skin stratum corneum moisture (%) Transepidermal water loss improvement rate (%) Example 1 80.2 43.8 Example 2 82.5 42.5 Example 3 80.4 43.4 Example 4 83.9 46.7 Comparative Example 1 72.4 30.5 Comparative Example 2 75.2 35.1 Comparative Example 5 78.6 39.4

[0128] Table 4

[0129]

[0130]

[0131] According to the test results in Table 3 and the evaluation results in Table 4, after using the compositions prepared in Examples 1-4 of the present invention for 4 weeks, the water content of the stratum corneum of the skin increased significantly, indicating that the compositions prepared by the present invention have better moisturizing and water-locking effects; the reduction in skin water loss indicates that the compositions prepared by the present invention have a good effect of repairing damaged skin barrier, and have good breathability, are refreshing and non-greasy, and have excellent skin-tightening effects.

[0132] Changing the type of surfactant in Comparative Example 1-2, that is, adding only sodium stearoyl glutamate to the surfactant component, or replacing sodium stearoyl glutamate with octadecyl alcohol (other types of surfactants) will affect the formation of the network structure of the liquid crystal composition, thereby affecting the fluidity of the composition, thereby weakening the moisturizing and water-locking effect, and reducing the improvement rate of transepidermal water loss of the skin, indicating that the barrier repair effect of the composition is weakened, thereby affecting the breathability, freshness and skin firming effects of the composition to a certain extent, and reducing the user experience.

[0133] Changing the mass ratio of glycerol, hydrogenated lecithin and β-sitosterol in Comparative Example 5 will also affect the compounding effect of the liquid crystal emulsifier, thereby affecting the moisturizing and water-locking effect and barrier repair effect of the composition, and reducing the user experience.

[0134] In summary, the composition prepared by the present invention can form a stable and long-lasting water-locking barrier on the surface of the skin, thereby improving the hydrating effect and damaged barrier repair effect of the composition, having good breathability and skin tightening effect, and is refreshing and non-greasy, providing a good user experience.

[0135] The embodiments presented herein are merely illustrative of selected implementations according to the combination of all possible embodiments. The appended claims are not limited by the selection of examples that illustrate the features of the present invention. Some numerical ranges used in the claims also include subranges within them, and changes in these ranges should also be interpreted as being covered by the appended claims where possible.

Claims

1. A liquid crystal biomimetic water-locking and oxygen-permeable care composition, characterized by: The invention is composed of the following components by weight percentage: 20-40% glycerol, 5-10% hydrogenated lecithin, 5-10% phytosterols, 0.1-0.5% sodium stearoyl glutamate, 0.01-0.05% sodium methyl stearoyl taurate, 0.1-1% ceramide NP, 1-10% caprylic / capric triglyceride, 1-10% squalane, 0.1-1% tocopheryl acetate, 0.01-0.3% sodium DNA, 0.001-0.1% fibronectin, 0.001-0.1% soluble collagen and the balance water.

2. The liquid crystal biomimetic water-locking and oxygen-permeable care composition according to claim 1, characterized in that: The following components are calculated by weight percentage: Composition: Glycerin 22-38%, hydrogenated lecithin 6-8%, phytosterols 6-8%, sodium stearoyl glutamate 0.2-0.4%, sodium methyl stearoyl taurate 0.01-0.04%, ceramide NP 0.3-0.8%, caprylic / capric triglyceride 3-8%, squalane 3-8%, tocopheryl acetate 0.3-0.8%, sodium DNA 0.05-0.25%, fibronectin 0.005-0.08%, soluble collagen 0.005-0.08% and water as the balance.

3. The liquid crystal biomimetic water-locking and oxygen-permeable care composition according to claim 2, characterized in that: The following components are calculated by weight percentage: Composition: Glycerin 25-35%, hydrogenated lecithin 7-8%, phytosterols 7-8%, sodium stearoyl glutamate 0.25-0.35%, sodium methyl stearoyl taurate 0.025-0.035%, ceramide NP 0.5-0.7%, caprylic / capric triglyceride 4-6%, squalane 4-6%, tocopheryl acetate 0.4-0.7%, sodium DNA 0.1-0.2%, fibronectin 0.01-0.05%, soluble collagen 0.01-0.05% and water as the balance.

4. The liquid crystal biomimetic water-locking and oxygen-permeable care composition according to claim 1, characterized in that: The mass ratio of the sodium stearoyl glutamate to the sodium methyl stearoyl taurate is 5-20:

1.

5. The liquid crystal biomimetic water-locking and oxygen-permeable care composition according to claim 4, characterized in that: The mass ratio of the sodium stearoyl glutamate to the sodium methyl stearoyl taurate is 10:

1.

6. The liquid crystal biomimetic water-locking and oxygen-permeable care composition according to claim 1, characterized in that: The mass ratio of the glycerol, hydrogenated lecithin and phytosterols is 2-4:0.5-1:0.5-1.

7. The liquid crystal biomimetic water-locking and oxygen-permeable care composition according to claim 1, characterized in that: The mass ratio of the DNA sodium, fibronectin and soluble collagen is 10-20:1-5:1-5.

8. The liquid crystal biomimetic water-locking and oxygen-permeable care composition according to claim 1, characterized in that: The following components are calculated by weight percentage: Composition: Glycerin 32%, hydrogenated lecithin 8%, phytosterols 8%, sodium stearoyl glutamate 0.3%, sodium methyl stearoyl taurate 0.03%, ceramide NP 0.6%, caprylic / capric triglyceride 5%, squalane 5%, tocopheryl acetate 0.6%, sodium DNA 0.15%, fibronectin 0.03%, soluble collagen 0.03% and water as the balance.

9. The method for preparing the liquid crystal biomimetic water-locking and oxygen-permeable care composition according to any one of claims 1 to 8, characterized in that: The steps include: (1) Glycerin, hydrogenated lecithin, phytosterols, and sodium stearoyl glutamate are mixed, heated to 85-90° C., and stirred for 10-15 minutes to obtain a liquid crystal emulsifier base A; (2) ceramide NP, caprylic / capric triglyceride, squalane, and tocopheryl acetate were mixed and stirred to obtain solution B; (3) Add sodium DNA, fibronectin, and soluble collagen to water and disperse them evenly to obtain solution C; (4) Preserving the liquid crystal emulsifier base material A at 85-90°C, slowly adding solution B under stirring, stirring and dispersing evenly, and then maintaining the temperature for 20 minutes to obtain a mixed solution; (5) Slowly add solution C to the mixed solution, then perform high-speed emulsification and homogenization for 10 minutes, continue stirring at a constant temperature for 20 minutes, cool to 45°C and stir evenly to obtain the liquid crystal biomimetic water-locking and oxygen-permeable care composition.

10. Use of the liquid crystal biomimetic water-locking and oxygen-permeable care composition according to any one of claims 1 to 8 in the preparation of biomimetic water-locking and oxygen-permeable cosmetics.

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